300例腔隙性脑梗死临床资料回顾性分析
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摘要
目的:通过对腔隙性脑梗死(lacunar infraction, LI)患者的临床资料及影像学特征回顾性总结分析,来探讨腔隙性脑梗死的发病机制、发病特点和因素、症状学特征、定位诊断、超声影像学特点、并发症及预后,进一步增强对腔隙性脑梗死的全面认知,从而有效预防和早期干预治疗。方法:回顾性总结分析2010年5月至2010年12月在我院脑病脑病一科住院300例患者的临床资料,全部病例均经头颅MRI检查确诊,从年龄、性别等发病因素,高血压病、糖尿病和心脏疾病等危险因素,症状学,超声、影像学进行分析。结果:300例腔隙性脑梗死的平均发病年龄为67.98±10.17岁,性别分布男性多于女性,高血压病、糖尿病及冠心病为高危因素,MRI结果显示多发病灶居多,病灶多分布在底节区、小脑、脑干、丘脑等部位,临床类型以无症状型居多,有症状者主诉以头晕最多,颈部血管超声显示92%存在斑块,供血不足则以右侧椎动脉明显。结论:300例腔隙性脑梗死患者中60岁以上男性居多,吸烟对其可能有影响,高血压、糖尿病及心脏病对其发生影响很大,MRI上以多发病灶为主,主要集中在基底节等部位,颈部多有斑块存在,故在预防和早期干预治疗上,除注意生活和饮食习惯外,监测和管理好血压血糖尤为重要,并做好门诊及住院患者的随访登记,适时予以干预。
Objective:Tong of lacunar cerebral infarction (LI) patients lacunar infraction, clinical data were retrospectively analyzed and imaging characteristics, this paper discusses summary of lacunar cerebral infarction pathogenesis, clinical characteristic and factors, symptoms learning characteristics, positioning diagnosis, ultrasonic imaging features, complications and prognosis, further strengthens of lacunar cerebral infarction of the overall cognitive, thus effectively prevent and early intervention. Methods: Retrospective summary analysis in May 2010 to December 2010 encephalopathy in our hospital from encephalopathy subject hospital clinical data of 300 patients, all patients were diagnosed by head MRI. from age. gender,etc triggers, hypertension, diabetes and heart disease risk factors, symptoms, ultrasound, imaging study analyzed. Results:300 cases of lacunar cerebral infarction average onset ages for 67.98+10.17 years old men more than women, gender, hypertension, diabetes and coronary heart disease for high-risk factors, MRI showed multiple lesions in the majority, the distribution of lesions many sections, the cerebellum, brainstem, thalamus, clinical types to areas such as the majority, have no symptoms type by dizziness who complained of symptoms most, neck vascular ultrasound shows 92% exist in patches, vibe vertebral artery obviously is on the right.Conclusion:300 cases of lacunar cerebral infarction patients men over 60 of its majority, smoking may have some effect, high blood pressure, diabetes and heart attacks occur on its impact, mainly with multiple lesions on MRI, mainly in the basal ganglia, neck areas such as many plaques, reason in existence on prevention and early intervention, except note life and eating habits outside, monitoring and management good blood glucose, blood pressure is especially important and make outpatient and inpatient timely follow-up of registration, intervene.
引文
[1]王世芳,徐立,肖卫民.急性多发性与单发性腔隙性脑梗死危险因素差异的探讨.新医学,2008,39(8):504-506.
    [2]王维治,罗祖明主编.神经病学[M].第5版.北京:人民卫生出版社,2004:141-143.
    [3]Liem MK,Grond JV,Haan J,etal Lacunar infarcts are the main correlate with cognitive dysfunction in CADASIL[J].Stroke,2007,38:9.
    [4]Norrving B. Lacunar infarcts no black holes in the brain are benign[J]. Practical Neurology,2008,8:222.
    [5]Viswanathan A,Gschwendtner A,Guichard JP,etal Lacunar lesions are independently associated with disability and cognitive impatiment in CADASIL[J]. Neurology, 2007,69:172.
    [6]JM Wardlaw.What causes lacunar stroke[J]? J Neurol Neurosurg Psychiatry 2005,76(5):617-619.
    [7]Lastilla M.Lacunar infarct[J].Clin Exp Hypertens,2006,28(34):205-215.
    [8]Audebert HJ,Pellkofer TS,Wimmer ML,et al.Progression in lacunar stroke is related to elevated acute phase parameters [J].Eur Neurol,2004,51:125-131.
    [9]Tei H,Uchiyama S,Usui T.Clinical-diffusion mismatch defined by NIHSS and ASPECTS in non-lacunar anterior circulation infarction[J].J Neurol,2007,254(3): 340-346.
    [10]You R,McNeil JJ,OMalley HM,etal Risk factors for lacunar infarction syndromes Neurology,1995;45:1483.
    [11]孙宁玲.高血压脑卒中的研究[J].临床内科杂志,1999,16(1):9210.
    [12]姥义,赵宝珍,柳标,等.超声对颈内动脉严重狭窄或闭塞时颅内侧支循环情况的评价.中国医学影像技术,2006,5(22):711-713.
    [13]王薇,赵东,赵静.中国35-64岁人群心血管危险因素与发病危险预测模型的前瞻性研究.中华心血管病杂志,2003,31:902-905;
    [14]Vitoore,RopperAA.Adams and Victorsprinciple of neurology [M].7thed.McGraw-Hill Co,2001:841-851.
    [15]杜岩,任艳.脑梗塞患者颈动脉粥样硬化的研究[J].中国医药导刊,2007,9(4):296.
    [16]Chambless LE,Folsom AR,Clegg LX,etal Carotid wall thickness is predictive of incident clinical stroke the atheroscle ros is risk in communities(ARIC) study [J]. Am J Epidemiol,2000,151 (5):478-487.
    [17]顾慎为编著.经颅多普勒检测与临床[M].第2版.上海:复旦大学、上海医科大学出 版社,2001.112.
    [18]ArboixA,AltesE,Massons J,etal Clinal study of lacunarinfacts in non-hypterfensive patients[J].J Stroke Cerebrovasc,2003;12(5):47-52.
    [19]王维治.神经病学[M].北京:人民卫生出版社,2004.141.
    [20]邰胜,刘志华.70岁以上老年高血压合并腔隙性脑梗死患者动态血压特征.临床荟萃,2008,23(2):91-93.
    [21]丁明钊,刘晗睿,李昆屯.腔隙性脑干梗死的临床分析[J].长治医学院学报,2004,18(2):94.
    [22]赵尔君,吕友梅.腔隙性脑梗死126例相关危险因素分析[J].中国现代医药杂志,2007,9(8):115-116.
    [23]李骋,马维亚,刘艳丽,等.腔隙性梗塞相关危险因素及影像学的研究[J].中华临床医学研究杂志,2003,8(1):26-27.
    [24]Verdelho A,Madureira S, Ferro JM,etal Different impact of cerebral white matter changes,diabetes,hypertension and stroke on cognirive performance among non-disabled elderly.The LADIS study[J].JNeurology Neurosurgery Psychiatry, 2007,78:1325.
    [25]李永鸿,周庆昆,卢颖瑜.腔隙性脑梗死197例临床分析[J].实用医学杂志,2005,21(13):1451-1452.
    [26]王吉耀,廖二元,胡品津.内科学.人民卫生出版社,2005:969.
    [27]吕媛,易尚辉,李旭红,等.脑梗塞复发危险因素的Logistic回归分析[J].湖南师范大学自然科学学报,2007,30(1):85-87.
    [28]章成国,张虹桥,谢坚,等.缺血性脑血管病与颈动脉粥样硬化的关系[J].中华神经科杂志,2006,39(12):832.
    [29]Jander S,SitzerM,WendtA,etal Expression of tissue factor in high-grade carotid artery stenosis association with plaque destabilization[J].Stroke,2001,32(4):850-854.
    [30]华杨、颈动脉粥样硬化性缺血性脑血管病的超声检测与应用.中国现代神经疾病杂志,2006,6(7):346-3521.
    [31]王广雨,刘家丰,于卫刚.超敏C-反应蛋白对冠状动脉钙化积分的预测价值.国外医学:老年医学分册,2005,26(3):104-105.
    [32]孟宪辉,程卫东,王怀敏,等.脑干梗死50例分析[J].吉林医学,2004,25(5):59.
    [33]王艳炜,何精选,程雄飞,等.椎动脉前部的解剖研究及其临床意义[J].局部手术学杂志,2007,16(5):326.
    [34]COSAR M,YAMAN M,ESER O,et al. Basilar artery angulation and vertigo due to the hemodynamic effect of dominant vertebral artery[J].Med Hypotheses,2008,70(5): 941-943.
    [35]NISHIKATA M,HIRASHIMA Y,TOMITA T,et al.Measurement of basilar artery bending and elongation by magnetic resonance cerebral angiography relationship to age,sex and vertebral artery dominance arch[J].Gerontol Geriatr,2004,38(3):251-259.
    [36]田时雨,吴多斌.短暂性脑缺血发作的临床研究.新医学,2006,37(11):710-712.
    [37]RomanGC,RoyallDR.Executivecontrolfunction:arationalbasisforthediagnosisofvascul ardemen[J].AlzheimerDisAssocDisord,1999,13(Suppl3):S69-S80.
    [38]Sharp DJ,Scott SK, Mehta MA,etal The neural correlates of declining performance with age:evidence for age-related changes in cognitive control[J].Oxford University Press,2006,16:1739.
    [39]姜静波,赵明伦1腔隙性脑梗死[J]1现代诊断与治疗,2000,11(1):59-60.
    [40]编辑部述评1腔隙性脑梗死[J]1高血压杂志,2005,13(5):257-258.
    [41]O'Brien JT,Erkinjuntti T,Reisberg B,et al. Vascular cognitive impairment[J]. LancetNeurology,2003,2:89-98.
    [42]凌国喜,荣阳,荣根满,等.尿激酶溶栓治疗急性脑梗死的临床研究[JJ.中国医药导报,2007,4(29):36-37.
    [1]刘素蓉,高艳琼,王敏无.症状脑梗死相关因素的研究[J].医学综述,2006,12(20):1254-1256.
    [2]苏长海,陈金波,刘庆新,等.老年人无症状性脑梗死的病因及影像学研[J].州医学院学报,2007,30(1):19-21.
    [3]牛琦,杨期东,刘运海,等.337例无症状脑梗塞的临床分析[J].临床神经病学杂志,2004,17(1):56-57.
    [4]VERMEERSE,KOUDSTAALPJ,OUDKERKM,etalPrevalenceandriskfactorsofsilentb raininfarctsinthepopu21ation2basedRotterdamscanstudy[J].Stroke,2002,33:21.
    [5]KASECS,WOLFPA,CHODOSHEH,etal.Prevalenceofsilentstrokeinpatientspresenting withini短暂性脑缺血发作(TIA)lstroke:thefram2inghamstudy[J]. Stroke,1999,20(7): 850.
    [6]KoharaK,JiangY,IgaseM,etal.Postprandianlhypotensionisassociat2edwithasymptomati ccerebrovasculardamageinessen短暂性脑缺血发作(TIA)lhypertensivepatients[J].Hypertension,1999,33:565.
    [7]Mori D,Yano K,Tsubota K, et al Simulation of platelet adhension and aggregation regulated by fibrinogen and von W illebrand factor[J].Thromb Haemost,2008,99(1): 108-15.
    [8][8]KaposztaZ,YoungE,BathPM,etal.Clinicalapplicationofasymp2tomaticembplicsigna ldetedtioninacutestroke:aprospectivestudy[J].Stroke,1999,30(9):1814.
    [9]CarP,ZannettiS,GiordanoG,etal.Cerebraltomographicfindingsinpatientsundergoingcaro tidendarterectomyforasymptomaticcarotidstenosis:short2termandlong2termimplicatio ns[J].JVascSurg,1999,29(6):99
    [10]TakahashiW,TakagiS,IdeM,etal.Globalreductionofcerebralglu2cosemetabolisminperso nswithsymptomaticaswellasasymptomaticla2cunarinfarction[J].KeioJMed,2000,49(su pp1:1):498.
    [11]SLITENJV.Computertechnologyinbiomaterialsscienceandengineering[M].NewYork:C hichester,2000.180.
    [12]张峻,侯有魁,王一友,等.三维CT重建在胫骨平台骨折中的应用[J].中华骨科杂志,1998,18(7):387.
    [13]Henskens LH, van Oostenbiugge RI, Kroon AA, et al Detection of silient cerebrovascular disease refines risk stratification of hyperetensive patients[J]J Hypertens,2009,(4):846-853.
    [14]Kwon HM, Kim BI, Oh JY, et al Retionpathy as an indicator of silent brain infarction in asymptom atic hypertensive subjects [J].J Neurol Sci,2007,252(2):159-162.
    [15]潘登,师桂萍,李保东.无症状脑梗死危险因素及影像学特征的临床研究[J].白求恩军医学院学报,2007,1(2):3-5.
    [16]曹红,孙长凯,赵耿毅,等.C-反应蛋白水平与脑梗死病情及预后的量化研究[J].中国现代神经疾病杂志,2005,5(2):84-87.
    [17]Packard R R, Libby P. Inflammation in atherosclerosis:from vascular biology to biomarker discovery and risk prediction [J].Clin Chem,2008,54(l):24-38.
    [18]KoharaK,ZhaoB,JiangY,etal.Relationofleftventricularhypertrophyandgeometrytoasym ptomaticcerebrovasculardamageinessen hyper2tension[J].AMJCardiol,1999,83(3):367.
    [19]Shaip DJ Scott SK, Mehta MA, et al The neural correlates of decilning performance with age:evidence for age-related changes incognitive control [J].Oxford University Press,2006,16:1739
    [20]刘祥琴,刘小琦,蒋萍,等.阿尔茨海默病和血管性痴呆患者血浆硫化氢与同型半胱氨酸水平的变化及意义[J].中华医学杂志,2008,88(32):2246.
    [21]马建军,张连仲,李学,等.老年无症状性脑梗死患者血清同型半胱氨酸水平和颈动脉粥样硬化的关系[J].郑州大学学报(医学版),2008,43(5):938-940.
    [22]Agnati LF, Genedani S, Rasio G, et al. Studies on homocysteine plasma levels in Alzheimer's patients. Relevance for neurodegeneratio [J].J Neural Transm,2005, 112:163-169.
    [23]Tyagi SC, Lominadze D, Roberts AM. Homocysteine in microvascular endothelial cell barrier permeability [J]. Cell Biochem Biophys,2005,43:37-44.
    [24]JojiI,YurieT,SatoshiH,etal.Low-grade inflammation is a risk factor for clinical stroke events in addition to silent cerebral infarcts in Japanese older hypertensives:the jichi medical school ABPM study, Wavel.Stroke,2007,38:911-917.
    [25]WITYKRJ,CHANGHM,ROSENGARTA,etal.Proxi2malextracranialvertebralarterydis easeintheNewEnglandMedicalCenterPosteriorCirculationRegistry [J]. ArchNeu2rol,19 98,55(4):47.
    [26]Vermeer SE, Den-Heijer T, Koudstaal PJ, et al. Incidence and risk factors of silent braininfarcts in the population-based Rotterdam Scan Study[J].Stroke,2003,34(2): 392-396.
    [27]张朝辉,宋景贵,王夏红,等.腔隙性脑梗死60例抑郁情绪及P300电位的对照观察[J].新乡医学院学报,2006,23(1):14-15.
    [28]颜凯世,阚明晴.静息性脑梗死的临床与特点[J].医学理论与实践,2007,20(1):37-38.
    [29]NakaneH,IbayashiS,FujiiK,etal.Cerebralbloodflowandmetabolisminpatientswithsilent braininfarction:occulemiseryperfu2sioninthecerebralcortex[J].JNeurolNeurosurgPsych iatry,1998,65(3):317-321.
    [30]张健,张福平.无症状性脑梗死预后的研究[J].中风与神经疾病杂志,1999,16(4):225-226.
    [31]程乐群1无症状性脑梗塞121例临床分析1J21中国实用神经疾病 志,2006,9(3):79-80.
    [32]PriceTR,ManolioTA,KronmaBA,etal.Silentbraininfarctiononmagneticresonanceimagi ngandneurologicalabnormalitiesincommu2nity-dwellingolderadults[J].Cadiovascular HealthStudyStroke,1997,28:1158-1164.
    [33]刘琨,王婷,李玉梅,等.无症状性脑梗死患者智能障碍及相关因素研究.中国临床心理学杂志,2001,9(1):10-12.
    [34]Barker RN, Gill TJ, Brauer SG. Factors contributing to upper limb recovery after stroke:a survey of stroke survivors in Queensland Australia [J].Disabil Rehabil, 2007,29(13):981.
    [35]Chakrabarti R, Das SK. Advances in antithrombotic agents [J].Cardiovasc Hematol Agents Med Chem,2007,5(3):175.
    [36]Ginsberg MD. Life after cerovive:a personal perspective on ischemic neuroprotection in the post-NXY-059era [J].Stroke,2007,38(6):1967.
    [37]Hazell AS. Excitotoxic mechanisms in stroke:anupdate of concepts and treatment strategies [J].Neurochem Int,2007,50(7-8):941.
    [38]Romero JR. Prevention of ischemic stroke:overview oftraditional risk factors [J],Curr Drug Targets,2007,8(7):794.

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