新加坡地区功能性消化不良（胃痞）中医证候学研究
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摘要
研究目的:采用流行病学调查的方法,对新加坡地区功能性消化不良发病人群的发病因素、年龄、性别以及临床中医证候学调查。通过本研究了解新加坡地区FD的病因及发病情况;通过分析揭示新加坡地区FD中医证候分布特点和规律;为建立新加坡地区FD中医证候诊断标准和评价标准提供依据。并希望本研究结果进一步丰富新加坡地区中医治疗胃痞证的内容、方法和手段。
研究方法:本研究将在中医基本理论的指导下,遵照循证医学和流行病学调查的原则,采用门诊问卷的方式,多点位的对新加坡地区的符合FD诊断标准的患者进行调查。本研究通过查阅关于痞满的中医古典文献和现代中医病因病机及治疗研究进展文献,并对中医临床证候和客观指标进行了较系统回顾和总结。遵照《中药新药临床研究指导原则》、《中医内科学》关于“胃痞”有关章节,收集并找出中医“胃痞”的相关症状;研究制定流行病学调查表格;由专门的医师对FD患者进行调查。一共收集150例功能性消化不良患者的临床资料,最后将得到的数据输入电脑,建立数据库,进行统计学分析,得出结论。
研究结果:1.患者年龄、性别、病因在中医证候分布上差异无统计学意义。(P>0.05);2.功能性消化不良中医症状中以胃部胀、脘腹痛、恶心、早饱、纳呆的出现频率为最高,依次占94.67%、92.00%、91.33%、89.33%、86.00%。;3.中医证型分布为脾胃虚弱型占31.33%,肝胃不和型占27.33%,脾胃湿热型占18.67%,饮食停滞型占14.00%,寒热错杂型8.67%。不同性别和年龄中中医证候的分布差异无统计学意义。(P>0.05);4.不同诱因中各种中医证候的分布上差异有统计学意义(P <0.01)。
结论:1.功能性消化不良中医证候分布与年龄、性别、病因无关。2.功能性消化不良主症为胃部胀、脘腹痛、恶心、早饱、纳呆。3.功能性消化不良以脾胃虚弱证和肝胃不和证为主,性别与年龄中医证候分布无关。4.功能性消化不良诱因与中医证候有关。
Objective: Epidemiological survey methods, the Singapore regional incidence of functional dyspepsia crowd pathogenic factors, age, gender and clinical TCM investigation. Research by the Singapore region FD understanding of the etiology and pathogenesis; Singapore analysis reveals areas FD TCM distribution characteristics and laws; for the establishment of the Singapore regional FD TCM diagnosis and evaluation criteria provide a basis. And the results will further enrich the Singapore Chinese medicine treatment areas Wei-pi certified content, methods and means.
Methods : In this study, the basic theory in Chinese medicine, under the guidance of compliance with evidence-based medical and epidemiological surveys, out-patient questionnaire used, the more points are located on the Singapore meet the diagnostic criteria for FD patients. The swelling of the liver through the full inspection of the Chinese classical and modern Chinese literature Pathogenesis and Treatment Progress literature, as well as clinical syndromes and objective indicators of systematically reviewed and summed up. Comply with the《Chinese medicine clinical research guiding principles》,《Chinese medical science》on the "Wei-pi" relevant sections Chinese collect and identify the "Wei-pi" related symptoms; Epidemiological study and formulate survey forms; by specialized physicians of FD patients. Collected a total of 150 cases of functional dyspepsia patients with clinical data, the final data will be the put into the computer establish a database for statistical analysis concludes.
Results: 1. The patient's age, sex, cause of the TCM distribution differences were not statistically significant(P>0.05). Chinese functional dyspepsia symptoms in the stomach bulging, Needle abdominal pain, nausea, early satiety, torpid intake frequency of the highest 94.67%, 92.00%,91.33%,89.33%,86.00% followed. 3. TCM distribution for the weak stomach-31.33%, and non-hepatogastric accounted for 27.33%. Damp-heat-type accounted for 18.67%, restaurants stagnation-accounting for 14.00%, 8.67% cold-mixed. Gender and age TCM no difference in the distribution of statistical significance. (p>0.05) 4. Various different incentives TCM distribution of the difference was statistically significant. (P<0.01) 5. Functional dyspepsia patients with different types of symptoms certification difference.
Conclusions: 1. Functional dyspepsia TCM distribution of age, gender, unrelated causes. 2. Functional dyspepsia main symptoms of stomach bulging, Needle abdominal pain, nausea, early satiety, torpid intake. 3. Functional dyspepsia stomach hepatogastric weak card and card-based and not, gender and age distribution of TCM irrelevant. 4. Functional dyspepsia incentives with the TCM. 5. Functional dyspepsia between different syndromes of different symptoms.
研究方法:本研究将在中医基本理论的指导下,遵照循证医学和流行病学调查的原则,采用门诊问卷的方式,多点位的对新加坡地区的符合FD诊断标准的患者进行调查。本研究通过查阅关于痞满的中医古典文献和现代中医病因病机及治疗研究进展文献,并对中医临床证候和客观指标进行了较系统回顾和总结。遵照《中药新药临床研究指导原则》、《中医内科学》关于“胃痞”有关章节,收集并找出中医“胃痞”的相关症状;研究制定流行病学调查表格;由专门的医师对FD患者进行调查。一共收集150例功能性消化不良患者的临床资料,最后将得到的数据输入电脑,建立数据库,进行统计学分析,得出结论。
研究结果:1.患者年龄、性别、病因在中医证候分布上差异无统计学意义。(P>0.05);2.功能性消化不良中医症状中以胃部胀、脘腹痛、恶心、早饱、纳呆的出现频率为最高,依次占94.67%、92.00%、91.33%、89.33%、86.00%。;3.中医证型分布为脾胃虚弱型占31.33%,肝胃不和型占27.33%,脾胃湿热型占18.67%,饮食停滞型占14.00%,寒热错杂型8.67%。不同性别和年龄中中医证候的分布差异无统计学意义。(P>0.05);4.不同诱因中各种中医证候的分布上差异有统计学意义(P <0.01)。
结论:1.功能性消化不良中医证候分布与年龄、性别、病因无关。2.功能性消化不良主症为胃部胀、脘腹痛、恶心、早饱、纳呆。3.功能性消化不良以脾胃虚弱证和肝胃不和证为主,性别与年龄中医证候分布无关。4.功能性消化不良诱因与中医证候有关。
Objective: Epidemiological survey methods, the Singapore regional incidence of functional dyspepsia crowd pathogenic factors, age, gender and clinical TCM investigation. Research by the Singapore region FD understanding of the etiology and pathogenesis; Singapore analysis reveals areas FD TCM distribution characteristics and laws; for the establishment of the Singapore regional FD TCM diagnosis and evaluation criteria provide a basis. And the results will further enrich the Singapore Chinese medicine treatment areas Wei-pi certified content, methods and means.
Methods : In this study, the basic theory in Chinese medicine, under the guidance of compliance with evidence-based medical and epidemiological surveys, out-patient questionnaire used, the more points are located on the Singapore meet the diagnostic criteria for FD patients. The swelling of the liver through the full inspection of the Chinese classical and modern Chinese literature Pathogenesis and Treatment Progress literature, as well as clinical syndromes and objective indicators of systematically reviewed and summed up. Comply with the《Chinese medicine clinical research guiding principles》,《Chinese medical science》on the "Wei-pi" relevant sections Chinese collect and identify the "Wei-pi" related symptoms; Epidemiological study and formulate survey forms; by specialized physicians of FD patients. Collected a total of 150 cases of functional dyspepsia patients with clinical data, the final data will be the put into the computer establish a database for statistical analysis concludes.
Results: 1. The patient's age, sex, cause of the TCM distribution differences were not statistically significant(P>0.05). Chinese functional dyspepsia symptoms in the stomach bulging, Needle abdominal pain, nausea, early satiety, torpid intake frequency of the highest 94.67%, 92.00%,91.33%,89.33%,86.00% followed. 3. TCM distribution for the weak stomach-31.33%, and non-hepatogastric accounted for 27.33%. Damp-heat-type accounted for 18.67%, restaurants stagnation-accounting for 14.00%, 8.67% cold-mixed. Gender and age TCM no difference in the distribution of statistical significance. (p>0.05) 4. Various different incentives TCM distribution of the difference was statistically significant. (P<0.01) 5. Functional dyspepsia patients with different types of symptoms certification difference.
Conclusions: 1. Functional dyspepsia TCM distribution of age, gender, unrelated causes. 2. Functional dyspepsia main symptoms of stomach bulging, Needle abdominal pain, nausea, early satiety, torpid intake. 3. Functional dyspepsia stomach hepatogastric weak card and card-based and not, gender and age distribution of TCM irrelevant. 4. Functional dyspepsia incentives with the TCM. 5. Functional dyspepsia between different syndromes of different symptoms.
引文
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[2]LOCKE GR. Prevalence,incidence. And natural history of dyspesia and functional dyspepsia [J]. Clin gastroenterol,1988,12 (3):435-42
[3]SCHMDT,VM,BYTZER P. Dyspepsia. Investigation and treatment [J]. Ugeskr Laeger, 2001.163(37):4990. 4
[4]陈雯湖,等.广东城镇居民消化不良的流行病学调查.中华内科杂志,1998,37(5):312
[5]田德禄,殷凤礼,王长洪.447 例纤维胃镜象与舌诊观察.中医杂志,1981,11:23~26
[6]董建华,唐旭东.通降论学术思想整理.北京中医药大学学报,1995,13 (2):45
[7]卜平, 李登銮, 朱海航等.疏肝健脾法治疗肝郁脾虚型功能性消化不良疗效观察.中国中西医结合脾胃杂志,1996,4(3):134
[8]余莉芳,连新崇.中医辨证治疗非溃疡性消化不良的探讨.中医杂志,1994,35(2):89
[9]梁乃津,黄穗平.健中调肝汤方治疗非溃疡性消化不良的临床观察.新中医, 1996 (9):8
[10]罗日永,等.485 例功能性消化不良患者中医证型相关因素分析.新中医,1997,29(12):13
[11]尚云.和胃健运汤治疗非溃疡性消化不良的临床观察.中医杂志,1998,39(3):168
[12]严光俊,等.活血化瘀法治疗性消化不良的临床观察.湖北中医杂志,2002,11(24):20
[13]李子俊,等.金龙汤治疗非溃疡性消化不良的临床观察.中国中西医结合脾胃杂志,1999,7(1):19～21
[14]胡品津.功能性消化不良[J].新医学,2001,32(1):623～624
[15]黄晓东.功能性消化不良的病理机制研究. 临床消化病杂志,2000,12(增 刊) :38-39
[16]侯晓华,李启祥,谢小平等.功能性消化不良患者的胃液体排空和胃感觉阈异.胃肠病学,2000,5(3):166～168
[17]Testoni PA. Interdigestive an troduodenal motor disorders in funtional dyspepsia. Associated chronic gastrit is co rrelates with a furthermo to rimpairment. Ital JGastroenterol,1992, 24: 440
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