生物医学光子学成像的若干关键技术研究
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摘要
作为一种非入侵、无损、高分辨率的成像方法,生物医学光子学成像技术近年来发展迅速,成为生命科学领域与光学领域的研究热点。本文采用理论分析、模拟、实验及应用相结合的研究方法,对生物医学光子学成像中的若干关键技术展开研究,着重对自适应相位补偿的超短脉冲双光子显微成像技术和共路频域光学相干层析成像技术进行分析,提供了在组织成像、内窥、外科手术引导成像等方面应用受限的解决方案。
首先本文从非线性光学出发介绍了双光子显微成像技术的理论及其优势,对自适应相位补偿(同时补偿低阶色散和高阶色散)的超短脉冲(10 fs)双光子成像系统进行了详细阐述,展现了在补偿后超短脉冲获得的一系列优势;首次对双光子显微成像中的高阶色散进行理论推导和量化分析,通过分析超短脉冲双光子系统中光学材料和棱镜对的色散,发现了整个系统高阶色散的来源;整理了双光子显微系统中使用长脉冲和短脉冲的优劣,并证明了在生物医学成像应用中,超短脉冲在没有进行自适应补偿的情况下,效率和激发强度甚至低于长脉冲情况。
然后本文从光学层析成像的理论基础出发介绍了频域光学相干层析成像的原理和特点,对基于共路的光学相干层析成像系统进行了详细的描述;首次提出并分析了三种不同的共路光学相干层析成像系统中光纤束内窥探头的聚焦系统,还对系统的信噪比进行分析从而对探头的结构进行参数优化;首次对光学相干层析成像技术添加了拓扑补偿和运动补偿功能,为表面拓扑差异过大导致OCT应用受到限制以及外科手术引导中组织无意识的跳动和运动造成成像伪影导致错误引导手术等问题提供了有效的解决方案。
综上所述,本文解决了生物医学光子学成像中某些关键技术问题,为其更好更广泛的在组织成像、内窥以及外科手术引导成像奠定了基础。
With rapid development in recent years, biomedical optical imaging, as a non-invasive, non-destructive and high resolution imaging technique, has become a focus of study in the fields of life science and optics. In this dissertation work, several key techniques of biomedical optical imaging was investigated by using a theoretical analysis-simulation-experiment-application research method. The adaptive phase compensation ultrashort pulse two-photon microscopy and the common-path Fourier domain optical coherence tomography (OCT) were studied, providing the solution for limited used in tissue imaging, endoscopy, surgical procedure guidance imaging and so on.
Firstly, starting from the non-linear optics, the theory and advantages of two-photon microscopy were introduced. By describing the adaptive phase compensation (both low and high order dispersion are compensated) ultroshort pulse (10 fs) two-photon microscopy system in detail, the advantages of using ultroshort pulse after compensation were revealed. For the first time, the high order dispersion in two-photon microscopy was derivated theoretically and analyzed quantitatively. By studying the dispersion of optical materials and prism pairs in two-photon microscopy system, we found the origin of high order dispersion of the entire system. We discussed the advantages and disadvantages of long and short pulses in two-photon microscopy system, and showed that without adaptive phase compensation, the efficiency and excitation intensity of ultrashort pulses were even worse than long pulses for biomedical imging,
Secondly, starting from the theory of optical tomography, the principle and characters of Fourier domain OCT were introduced. The common path OCT system were described in detail. For the first time, we suggested and analysed three different focus systems for fiber bundle endoscopic probe of common path OCT system. Signal to noise ratio was analyzed to optimize the probe configuration. Moreover, a surface topology and motion compensation system was developed first time for OCT and can be used for various clinical applications.
In conclusion, we studied several key techniques of biomedical optical imaging, providing the better and wider applications in various fields, such as tissue imaging, endoscopy and surgical procedure guidance imaging.
首先本文从非线性光学出发介绍了双光子显微成像技术的理论及其优势,对自适应相位补偿(同时补偿低阶色散和高阶色散)的超短脉冲(10 fs)双光子成像系统进行了详细阐述,展现了在补偿后超短脉冲获得的一系列优势;首次对双光子显微成像中的高阶色散进行理论推导和量化分析,通过分析超短脉冲双光子系统中光学材料和棱镜对的色散,发现了整个系统高阶色散的来源;整理了双光子显微系统中使用长脉冲和短脉冲的优劣,并证明了在生物医学成像应用中,超短脉冲在没有进行自适应补偿的情况下,效率和激发强度甚至低于长脉冲情况。
然后本文从光学层析成像的理论基础出发介绍了频域光学相干层析成像的原理和特点,对基于共路的光学相干层析成像系统进行了详细的描述;首次提出并分析了三种不同的共路光学相干层析成像系统中光纤束内窥探头的聚焦系统,还对系统的信噪比进行分析从而对探头的结构进行参数优化;首次对光学相干层析成像技术添加了拓扑补偿和运动补偿功能,为表面拓扑差异过大导致OCT应用受到限制以及外科手术引导中组织无意识的跳动和运动造成成像伪影导致错误引导手术等问题提供了有效的解决方案。
综上所述,本文解决了生物医学光子学成像中某些关键技术问题,为其更好更广泛的在组织成像、内窥以及外科手术引导成像奠定了基础。
With rapid development in recent years, biomedical optical imaging, as a non-invasive, non-destructive and high resolution imaging technique, has become a focus of study in the fields of life science and optics. In this dissertation work, several key techniques of biomedical optical imaging was investigated by using a theoretical analysis-simulation-experiment-application research method. The adaptive phase compensation ultrashort pulse two-photon microscopy and the common-path Fourier domain optical coherence tomography (OCT) were studied, providing the solution for limited used in tissue imaging, endoscopy, surgical procedure guidance imaging and so on.
Firstly, starting from the non-linear optics, the theory and advantages of two-photon microscopy were introduced. By describing the adaptive phase compensation (both low and high order dispersion are compensated) ultroshort pulse (10 fs) two-photon microscopy system in detail, the advantages of using ultroshort pulse after compensation were revealed. For the first time, the high order dispersion in two-photon microscopy was derivated theoretically and analyzed quantitatively. By studying the dispersion of optical materials and prism pairs in two-photon microscopy system, we found the origin of high order dispersion of the entire system. We discussed the advantages and disadvantages of long and short pulses in two-photon microscopy system, and showed that without adaptive phase compensation, the efficiency and excitation intensity of ultrashort pulses were even worse than long pulses for biomedical imging,
Secondly, starting from the theory of optical tomography, the principle and characters of Fourier domain OCT were introduced. The common path OCT system were described in detail. For the first time, we suggested and analysed three different focus systems for fiber bundle endoscopic probe of common path OCT system. Signal to noise ratio was analyzed to optimize the probe configuration. Moreover, a surface topology and motion compensation system was developed first time for OCT and can be used for various clinical applications.
In conclusion, we studied several key techniques of biomedical optical imaging, providing the better and wider applications in various fields, such as tissue imaging, endoscopy and surgical procedure guidance imaging.
引文
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