高血压病五脏相关性及中药干预的研究
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摘要
原发性高血压病(Essential hypertension, EH)是一种以动脉血压升高为主的临床综合征,是常见的心血管疾病,易并发心、脑、肾等靶器官损害,具有较高的致残率,严重威胁人们的健康。中医药在防治EH有较好的作用,是目前研究的热点,因此,合理利用中医药发挥其优势有着重要的意义。
研究目的：
1.通过临床病例调查,探索高血压病五脏相关性及中医证型分布规律。
2.在五脏相关性理论指导下,运用中药干预治疗高血压病,观察其疗效。
研究方法：
1.高血压病五脏相关性研究：进行前瞻性高血压病病例调查收集2009年1月至2010年3月广东省第二中医院门诊或住院高血压病例200例,填写高血压五脏相关调查表,分析高血压病五脏相关的临床症状。
2.高血压病中医证型分布规律调查：对广东省第二中医院和中山市中医院近10年高血压病患者住院病例进行回顾性收集,填写调查表,分析高血压病中医证型分布规律。
3.中药干预治疗高血压病：收集2009年6月至2010年3月广东省第二中医院门诊或住院高血压病例120例,其中30例中医辨证属气虚痰浊的患者进行复方芪麻胶囊干预研究,30例中医辨证属肝火亢盛的患者进行平肝胶囊干预研究,另外60例其中气虚痰浊型和肝火亢盛型各30例作为对照组,对照组予基础治疗(硝苯地平缓释片20mg,2次／日和／或卡托普利12.5mg/25mg,3次／日),治疗组气虚痰浊型在对照组的基础治疗上加用复方芪麻胶囊(由黄芪、天麻等药物组成)2粒,3次／日；治疗组肝火亢盛型在对照组的基础治疗上加用平肝胶囊(龙胆草、栀子等药物组成)2粒,3次／日；每周随访一次,4周后观察治疗前后患者收缩压(SBP)、舒张压(DBP)、脉压差,头晕、头痛等临床症状,总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)等血脂指标的变化,以及不良反应情况。填写观察表,最后进行资料统计分析。评估中药制剂干预对调节血压、缩小脉压差、降低血脂、改善临床症状的治疗效果。
研究结果：
1.高血压病五脏相关性研究结果显示：高血压病患者临床表现多与心、肝、脾关系较为密切,这种现象符合邓老“五脏相关理论”的思想,表明高血压病五脏相关性客观存在。
2.高血压病中医证型分布规律调查结果：高血压病四类中医证型与各组间年龄分层有显著性差异(P<0.05),与性别无显著性差异(P>0.05),高血压病患者中以痰浊内阻型最为多见(56.8%),其次为肝火亢盛型(22.6%)、阴虚阳亢型(4.8%)和其他证型(15.7%)。
3.复方芪麻胶囊治疗气虚痰浊型高血压病临床疗效观察结果显示：治疗组降压总有效率为93.0%,对照组总有效率为88.3%,与对照组比较,治疗组疗效有显著性差异(P(0.05),治疗组症候总有效率为96.7%,对照组总有效率为93.3%,与对照组比较,治疗组症候疗效有显著性差异(P<0.05)；治疗组降低TC、TG,升高HLD总有效率为83.3%、83.3%、93.3%,对照组分别为30.0%、43.3%、40.0%,与对照组比较,治疗组调脂疗效均有显著性差异(P<0.01),与治疗前比较,治疗组及对照组血压疗效、症候疗效均有显著性差异(P<0.01),治疗组血脂疗效有显著性差异(P<0.01),对照组血脂疗效无显著性差异(P>0.05)。
4.平肝胶囊治疗肝火亢盛型高血压病临床疗效观察结果显示：治疗组降压总有效率为93.3%,对照组总有效率为83.3%,与对照组比较,治疗组疗效有显著性差异(P<0.05),治疗组症候总有效率为96.7%,对照组总有效率为83.3%,与对照组比较,治疗组症候疗效有显著性差异(P<0.05)；治疗组降低TC、TG,升高HLD总有效率为73.3%、80.0%、80.0%,对照组分别为26.7%、33.3%、36.7%,与对照组比较,治疗组调脂疗效均有显著性差异(P<0.01),与治疗前比较,治疗组及对照组血压疗效、症候疗效均有显著性差异(P<0.01),治疗组血脂疗效有显著性差异(P<0.01),对照组血脂疗效无显著性差异(P>0.05)。
结论：
1.高血压病五脏相关性客观存在,运用这一理论指导临床治疗高血压病有着确切的疗效。
2.高血压病中医证型分布按比例依次为痰浊内阻型>肝火亢盛型>阴虚阳亢型>其他证型。
3.复方芪麻胶囊和平肝胶囊分别在治疗气虚痰浊型高血压病和肝火亢盛型高血压病有着确切的疗效,考虑与其在降血压、缩小脉压差、调脂、改善症状等方面的疗效有关。
Essential Hyertension (EH) refers to a syndrome with characteristics of increased aortic blood pressure, which frequently being complicated by injuries of targeted organs such as brain, heart, kidney and etc,is a common cardiovascular disease as the main thereaten factor to the human health with high disability rate and seaverely decreases the life quality of human being.TCM has a dood effect in the prevention of EH, and has became the focus of modern research. Therefore, reasonable utilization of TCM exert its advantages has important significance.
Objective
1. Through clinical cases investigation, exploration Five zang-organ-related theory of hypertension and TCM syndrome type distribution.
2. Under the guidance of Five zang-organ-related theory, using the TCM treatment of hypertension, observe intervention.
Methods
1. Prospective investigation and collection of cases hypertension between January 2009 to March 2010 in the second TCM Hospital of Guangdong Province outpatient or in hospital hypertension 200 cases, fill in Questionnaire of hypertension Five zang-organ-related, Analysis of the relevant organs of hypertension symptoms.
2. All cases of patient records were selected from the 2nd TCM Hospital of Guangdong Province and TCM Hospital of Zhongshan County fill in cases were collected and analyzed the hypertension TCM syndrome type distribution.
3. Collecting 120 cases hypertension patients from second Guangdong hospital outpatient or in hospital between June,2009 to March,2010 30 cases of TCM syndrome differentiation of Qi deficiency and phlegm syndrome with the Compound Qima capsule intervention study,30 cases of TCM dialectical patients of Overabundant Liver-Fire syndrome, with the Pinggan capsule intervention study, Another 60 cases of Qi deficiency and phlegm syndrome and Overabundant Liver-Fire syndrome of 30 patients suffered various as control group, the control group treated by Nifedipine Sustained-release Tablets 20mg Bid and/or Captopril Tablets 12.5mg/25mg Tid;the treatment group treated with fthe same and add the Compound Qima Capsule 2 pill Tid or the Pinggan Capsule 2 pill Tid,and observe the indexes of improvement in clinical symptoms blood pressure controlling condition, four items test of blood lipid and side-effect occurrences.
Results
1. Hypertension Five zang-organ-related research results show that the essential hypertensive patients with clinical manifestations of heart, liver, spleen, this kind of phenomenon closely "Five zang-organ-related theory" by DengLao in the core idea of spleen center, That hypertension Five zang-organ-related theory exists objectively.
2. Hypertension TCM syndrome type distribution survey results:Hypertension four types of TCM syndrome type between age groups has significant differences (P (0.05), and gender has no significant difference (P> 0.05). Hypertension patients with Phlegm stasis syndrome (56.6%) on the most frequent Secondly is Overabundant Liver-Fire syndrome (22.6%). Yin Vacuity Due to Yang Hyperactivity (4.8%) and the other types (15.7).
3. The therapeutic efficacy result of Compound Qima Capsule for Qi deficiency and phlegm syndrome of hypertension indicate that therapeutic efficacy on blood pressure of the treatment group is 93.0%and that of the control group is 88.3%, there is statistic difference between them (P (0.05).Corres-ponding to the clinical treatment effect rate with 96.7%in comparison to 93.3%(P (0.05).the treatment group was superior to the control group in reducing TC、TG level and the former could enhance HDL index relating to the therapeutic effect on reducing blood lipid (P (0.01).
4. The therapeutic efficacy result of Pinggan Capsule for Qi deficiency and phlegm syndrome of hypertension indicate that therapeutic efficacy on blood pressure of the treatment group is 93.3%and that of the control group is 83.3%, there is statistic difference between them (P (0.05).Corresponding to the clinical treatment effect rate with 96.7%in comparison to 83.3%(P (0.05). the treatment group was superior to the control group in reducing TC、TG level and the former could enhance HDL index relating to the therapeutic effect on reducing blood lipid (P (0.01)
Conclusions
1. The hypertension Five zang-organ-related theory exists objectively, using this theory to guide clinical treatment of hypertension is exactly curative effect.
2. Hypertension TCM syndrome type distribution according to the proportion in order is Phlegm stasis、Overabundant Liver-Fire syndrome、Yin Vacuity Due to Yang Hyperactivity and the other types.
3. Compound Qima capsule and Pinggan capsule respective in the treatment of Qi deficiency and phlegm syndrome and h Qi deficiency and phlegm syndrome of hypertension has suffered exactly curative effect, Considering its blood pressure、narrowing pulse blood pressure、cholesterol-lowering、improve symptoms related aspects of the curative effect.
研究目的：
1.通过临床病例调查,探索高血压病五脏相关性及中医证型分布规律。
2.在五脏相关性理论指导下,运用中药干预治疗高血压病,观察其疗效。
研究方法：
1.高血压病五脏相关性研究：进行前瞻性高血压病病例调查收集2009年1月至2010年3月广东省第二中医院门诊或住院高血压病例200例,填写高血压五脏相关调查表,分析高血压病五脏相关的临床症状。
2.高血压病中医证型分布规律调查：对广东省第二中医院和中山市中医院近10年高血压病患者住院病例进行回顾性收集,填写调查表,分析高血压病中医证型分布规律。
3.中药干预治疗高血压病：收集2009年6月至2010年3月广东省第二中医院门诊或住院高血压病例120例,其中30例中医辨证属气虚痰浊的患者进行复方芪麻胶囊干预研究,30例中医辨证属肝火亢盛的患者进行平肝胶囊干预研究,另外60例其中气虚痰浊型和肝火亢盛型各30例作为对照组,对照组予基础治疗(硝苯地平缓释片20mg,2次／日和／或卡托普利12.5mg/25mg,3次／日),治疗组气虚痰浊型在对照组的基础治疗上加用复方芪麻胶囊(由黄芪、天麻等药物组成)2粒,3次／日；治疗组肝火亢盛型在对照组的基础治疗上加用平肝胶囊(龙胆草、栀子等药物组成)2粒,3次／日；每周随访一次,4周后观察治疗前后患者收缩压(SBP)、舒张压(DBP)、脉压差,头晕、头痛等临床症状,总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)等血脂指标的变化,以及不良反应情况。填写观察表,最后进行资料统计分析。评估中药制剂干预对调节血压、缩小脉压差、降低血脂、改善临床症状的治疗效果。
研究结果：
1.高血压病五脏相关性研究结果显示：高血压病患者临床表现多与心、肝、脾关系较为密切,这种现象符合邓老“五脏相关理论”的思想,表明高血压病五脏相关性客观存在。
2.高血压病中医证型分布规律调查结果：高血压病四类中医证型与各组间年龄分层有显著性差异(P<0.05),与性别无显著性差异(P>0.05),高血压病患者中以痰浊内阻型最为多见(56.8%),其次为肝火亢盛型(22.6%)、阴虚阳亢型(4.8%)和其他证型(15.7%)。
3.复方芪麻胶囊治疗气虚痰浊型高血压病临床疗效观察结果显示：治疗组降压总有效率为93.0%,对照组总有效率为88.3%,与对照组比较,治疗组疗效有显著性差异(P(0.05),治疗组症候总有效率为96.7%,对照组总有效率为93.3%,与对照组比较,治疗组症候疗效有显著性差异(P<0.05)；治疗组降低TC、TG,升高HLD总有效率为83.3%、83.3%、93.3%,对照组分别为30.0%、43.3%、40.0%,与对照组比较,治疗组调脂疗效均有显著性差异(P<0.01),与治疗前比较,治疗组及对照组血压疗效、症候疗效均有显著性差异(P<0.01),治疗组血脂疗效有显著性差异(P<0.01),对照组血脂疗效无显著性差异(P>0.05)。
4.平肝胶囊治疗肝火亢盛型高血压病临床疗效观察结果显示：治疗组降压总有效率为93.3%,对照组总有效率为83.3%,与对照组比较,治疗组疗效有显著性差异(P<0.05),治疗组症候总有效率为96.7%,对照组总有效率为83.3%,与对照组比较,治疗组症候疗效有显著性差异(P<0.05)；治疗组降低TC、TG,升高HLD总有效率为73.3%、80.0%、80.0%,对照组分别为26.7%、33.3%、36.7%,与对照组比较,治疗组调脂疗效均有显著性差异(P<0.01),与治疗前比较,治疗组及对照组血压疗效、症候疗效均有显著性差异(P<0.01),治疗组血脂疗效有显著性差异(P<0.01),对照组血脂疗效无显著性差异(P>0.05)。
结论：
1.高血压病五脏相关性客观存在,运用这一理论指导临床治疗高血压病有着确切的疗效。
2.高血压病中医证型分布按比例依次为痰浊内阻型>肝火亢盛型>阴虚阳亢型>其他证型。
3.复方芪麻胶囊和平肝胶囊分别在治疗气虚痰浊型高血压病和肝火亢盛型高血压病有着确切的疗效,考虑与其在降血压、缩小脉压差、调脂、改善症状等方面的疗效有关。
Essential Hyertension (EH) refers to a syndrome with characteristics of increased aortic blood pressure, which frequently being complicated by injuries of targeted organs such as brain, heart, kidney and etc,is a common cardiovascular disease as the main thereaten factor to the human health with high disability rate and seaverely decreases the life quality of human being.TCM has a dood effect in the prevention of EH, and has became the focus of modern research. Therefore, reasonable utilization of TCM exert its advantages has important significance.
Objective
1. Through clinical cases investigation, exploration Five zang-organ-related theory of hypertension and TCM syndrome type distribution.
2. Under the guidance of Five zang-organ-related theory, using the TCM treatment of hypertension, observe intervention.
Methods
1. Prospective investigation and collection of cases hypertension between January 2009 to March 2010 in the second TCM Hospital of Guangdong Province outpatient or in hospital hypertension 200 cases, fill in Questionnaire of hypertension Five zang-organ-related, Analysis of the relevant organs of hypertension symptoms.
2. All cases of patient records were selected from the 2nd TCM Hospital of Guangdong Province and TCM Hospital of Zhongshan County fill in cases were collected and analyzed the hypertension TCM syndrome type distribution.
3. Collecting 120 cases hypertension patients from second Guangdong hospital outpatient or in hospital between June,2009 to March,2010 30 cases of TCM syndrome differentiation of Qi deficiency and phlegm syndrome with the Compound Qima capsule intervention study,30 cases of TCM dialectical patients of Overabundant Liver-Fire syndrome, with the Pinggan capsule intervention study, Another 60 cases of Qi deficiency and phlegm syndrome and Overabundant Liver-Fire syndrome of 30 patients suffered various as control group, the control group treated by Nifedipine Sustained-release Tablets 20mg Bid and/or Captopril Tablets 12.5mg/25mg Tid;the treatment group treated with fthe same and add the Compound Qima Capsule 2 pill Tid or the Pinggan Capsule 2 pill Tid,and observe the indexes of improvement in clinical symptoms blood pressure controlling condition, four items test of blood lipid and side-effect occurrences.
Results
1. Hypertension Five zang-organ-related research results show that the essential hypertensive patients with clinical manifestations of heart, liver, spleen, this kind of phenomenon closely "Five zang-organ-related theory" by DengLao in the core idea of spleen center, That hypertension Five zang-organ-related theory exists objectively.
2. Hypertension TCM syndrome type distribution survey results:Hypertension four types of TCM syndrome type between age groups has significant differences (P (0.05), and gender has no significant difference (P> 0.05). Hypertension patients with Phlegm stasis syndrome (56.6%) on the most frequent Secondly is Overabundant Liver-Fire syndrome (22.6%). Yin Vacuity Due to Yang Hyperactivity (4.8%) and the other types (15.7).
3. The therapeutic efficacy result of Compound Qima Capsule for Qi deficiency and phlegm syndrome of hypertension indicate that therapeutic efficacy on blood pressure of the treatment group is 93.0%and that of the control group is 88.3%, there is statistic difference between them (P (0.05).Corres-ponding to the clinical treatment effect rate with 96.7%in comparison to 93.3%(P (0.05).the treatment group was superior to the control group in reducing TC、TG level and the former could enhance HDL index relating to the therapeutic effect on reducing blood lipid (P (0.01).
4. The therapeutic efficacy result of Pinggan Capsule for Qi deficiency and phlegm syndrome of hypertension indicate that therapeutic efficacy on blood pressure of the treatment group is 93.3%and that of the control group is 83.3%, there is statistic difference between them (P (0.05).Corresponding to the clinical treatment effect rate with 96.7%in comparison to 83.3%(P (0.05). the treatment group was superior to the control group in reducing TC、TG level and the former could enhance HDL index relating to the therapeutic effect on reducing blood lipid (P (0.01)
Conclusions
1. The hypertension Five zang-organ-related theory exists objectively, using this theory to guide clinical treatment of hypertension is exactly curative effect.
2. Hypertension TCM syndrome type distribution according to the proportion in order is Phlegm stasis、Overabundant Liver-Fire syndrome、Yin Vacuity Due to Yang Hyperactivity and the other types.
3. Compound Qima capsule and Pinggan capsule respective in the treatment of Qi deficiency and phlegm syndrome and h Qi deficiency and phlegm syndrome of hypertension has suffered exactly curative effect, Considering its blood pressure、narrowing pulse blood pressure、cholesterol-lowering、improve symptoms related aspects of the curative effect.
引文
[1]唐蜀华.高血压病.江苏中医药,2004,25(10)：11
[2]王清海.论高血压的中医概念与病名.中华中医药学刊,2008,26(11)：2321-2323
[3]郭振球.高血压危险因素与微观证治学综合研究[J].山西中医,2001,17(6)：37-38
[4]扬帆.论治血与降压[J].国医论坛,2002,17(3)：41-42
[5]唐培立.高血压病气虚证中医辨证施治探微[J].新疆中医药,2001,19(2)：7
[6]李青鸟.原发性高血压病病因之我见[J].光明中医,2000,15(1)：8-11
[7]段学忠.益气养血活血法治疗老年高血压病的研究[J].山东中医药大学学报,1997,21(6)：423
[8]袁成民.八物降压冲剂治疗原发性高血压的临床及实验研究[J].山东中医药大学学报,1999,23(3)：189
[9]俞兴群,周宜轩,戴小华,等.养阴祛瘀汤治疗高血压病53例疗效观察[J].中国中医药信息杂志,1999,6(9)：38
[10]邵玉宝.降压稳压汤治疗原发性高血压54例观察[J].中国中医药信息杂志,1998,5(10)：30
[11]李反,杜辕滨,江惠萍,等.平肝逐瘀汤治疗高血压头痛62例[J].四川中医,2002,20(1)：46
[12]马国教,徐秋.补肾活血降压方治疗老年性高血压156例[J].陕西中医,1997,18(3)：106
[13]曹汉彬.健牌祛瘀降压方治疗舒张期高血压68例临床观察[J].新中医,2001,33(5)：35
[14]蔡家壁.活血化瘀治疗老年高血压病96例[J].辽宁中医杂志,2001,28(11)：673
[15]鞠大宏,韩学杰,谢雁呜,等.高血压病从络论治探讨[J].山东中医药大学学报,2001,7(9)：43.
[16]庄严.疏理肝脾调畅气机法治疗中青年原发性高血压机制探讨[J].山东中医杂志,2004,23(5)：264-265.
[17]程志清.老年高血压病证治特点[J].浙江中医学院学报,1999,23(6)：14-15.
[18]王劲红.张国伦教授运用益气活血法治疗老年高血压病经验[J].河北中医,2006,18(4)：247.
[19]邓旭光.高血压病中西医结合的临床诊治的思路与方法[J].中医杂志,2000,41(2)：113-115.
[20]邹志东,刘宁,郭鹏,等.北京地区近10年高血压病中医用药规律分析[J].中国中药杂志,2007,32(15)：1569-1572
[21]刘德桓,林惠琴,王秀宝,等.化瘀浊益肝肾法对原发性高血压患者生活质量的 影响[J].中国临床康复,2006,10(23)：9-12.
[22]高雅琦,叶穗林,等.老年收缩期高血压中医证型与颈动脉硬化的临床研究[J].广州中医药大学学报,2008,25(5)：461-463.
[23]王长洪.著名中医学家董建华教授学术经验系列之三——从肝论治高血压病的经验[J].辽宁中医杂志,1999,26(9)：390.
[24]邱志济,朱建平,马璇卿.朱良春治疗高血压病用药经验特色选析——著名老中医学家朱良春教授临床经验(28)[J].辽宁中医杂志,2002,29(4)：194-195.
[25]刘福明,赵东杰,范群丽.唐蜀华教授治疗高血压病撷萃[J].江苏中医药,2002,23(6)：8-9.
[26]吴焕林,林晓忠.邓铁涛运用调脾法治疗高血压病的临床经验[J].中国中医基础医学杂志,2005,11(5)：400-401.
[27]徐健儿.周仲瑛运用温阳法辨治高血压病的经验[J].辽宁中医杂志,2001,28(5)：276-277
[28]王清海,李桂明,李典鸿.高血压病中医证型分布规律的临床研究.新中医,2005；37(11)：26-27
[29]刘小斌.邓铁涛教授“五脏相关”学术源流探讨.广州中医药大学学报,2006,23(5)：424-427.
[30]日本·山田业广.素问次注集疏[M].北京：学苑出版社,2004：451.
[31]马继兴.敦煌古医籍考释[M].南昌：江西科技出版社,1988：18.
[32]丛春雨.敦煌中医药全书[M].北京：中医古籍出版社,1994：117.
[33]日本·丹波元胤.中国医籍考[M].北京：人民卫生出版社,1983：180.
[34]明·李梃.医学入门[M].北京：中国中医药出版社,1995：72.
[35]徐志伟,刘小斌,邱仕君,郑洪等,中医“五脏相关”理论继承与创新的初步研究.广州中医药大学学报.2008.25(6)：475-479.
[36]田代华.五行学说是制约中医理论发展的关键因素.山东中医药大学学报,2006,30(2)：96-97.
[37]刘小斌,邱仕君,郑洪,等.邓铁涛“五脏相关”理论研究.中国中医基础医学杂志,2008,14(1)：20-22.
[38]陈凯佳.邓铁涛五脏相关理论研究的方法和思路探讨.中医研究,2006,19(4)：46-48.
[39]何梦瑶.医碥[M].上海：上海科学技术出版社,1982.3-9.
[40]刘小斌,刘友章.邓铁涛教授五脏相关学说略介.上海中医药杂志,2002.7：36-37.
[41]邓铁涛.邓铁涛医集[M].北京：人民卫生出版社,1995.1-2.
[42]王清海,卢桂梅,李爱华等.血压健胶囊对高血压患者左室重构逆转作用的临床研究.河南中医,1998；18(2)：34-35.
[43]黄琳,王清海,李典鸿等.复方芪麻胶囊对气虚痰浊型高血压患者动态血压的影响.中国试验方剂学杂志,2004；10(5)：57-58.
[44]江苏新医学院.中药大辞典.上海：上海科学技术出版社,1986,第一版：220-236.
[45]阴健,中药现代研究与临床应用[M].北京：中医古籍出版社,1995：32.
[46]陈宁,王清海,李爱华等.血压健4号治疗气虚痰浊型高血压临床观察.中西医结合心脑血管病杂志,2004；2(5)：255-256.
[47]韩学杰,张印生.冠心病痰瘀互结证的渊源和创新.中国医药学报,2004；19(10)：623-625.
[48]沈映君.中药药理学.上海：上海科学技术出版社,1997：50-52、59-60、90-91、149-150.
[49]White WB, Weber MA, Davidai G, etc.Ambulatory blood pressure monitoring in the primary care setting, assessment of therapy on the circadian variation of blood pressure from the MICCAT-2 trail Blood Pressure Monit,2005; 10 (3): 157-163.
[50]王丽先,李风原.高血压病患者动态血压负荷、昼夜节律改变与左室肥厚关系的研究.陕西医学杂志,2001；30(2)：85-86.
[51]邓冰湘,等高血压病患者血压昼夜节律与靶器官损害及中医证型关系的研究.湖南中医学院学报,2004,24(6)：48-49.
[52]黄琳,王清海,等.平肝胶囊治疗肝火亢盛型高血压临床观察.中国中医药信息杂志,2004,11(4)：334-335.
[53]姜坤,张兰华,刘玉芳等.龙胆泻肝汤加减治疗高血压病血液流变性的临床观察.中医药.2002,2：58.
[2]王清海.论高血压的中医概念与病名.中华中医药学刊,2008,26(11)：2321-2323
[3]郭振球.高血压危险因素与微观证治学综合研究[J].山西中医,2001,17(6)：37-38
[4]扬帆.论治血与降压[J].国医论坛,2002,17(3)：41-42
[5]唐培立.高血压病气虚证中医辨证施治探微[J].新疆中医药,2001,19(2)：7
[6]李青鸟.原发性高血压病病因之我见[J].光明中医,2000,15(1)：8-11
[7]段学忠.益气养血活血法治疗老年高血压病的研究[J].山东中医药大学学报,1997,21(6)：423
[8]袁成民.八物降压冲剂治疗原发性高血压的临床及实验研究[J].山东中医药大学学报,1999,23(3)：189
[9]俞兴群,周宜轩,戴小华,等.养阴祛瘀汤治疗高血压病53例疗效观察[J].中国中医药信息杂志,1999,6(9)：38
[10]邵玉宝.降压稳压汤治疗原发性高血压54例观察[J].中国中医药信息杂志,1998,5(10)：30
[11]李反,杜辕滨,江惠萍,等.平肝逐瘀汤治疗高血压头痛62例[J].四川中医,2002,20(1)：46
[12]马国教,徐秋.补肾活血降压方治疗老年性高血压156例[J].陕西中医,1997,18(3)：106
[13]曹汉彬.健牌祛瘀降压方治疗舒张期高血压68例临床观察[J].新中医,2001,33(5)：35
[14]蔡家壁.活血化瘀治疗老年高血压病96例[J].辽宁中医杂志,2001,28(11)：673
[15]鞠大宏,韩学杰,谢雁呜,等.高血压病从络论治探讨[J].山东中医药大学学报,2001,7(9)：43.
[16]庄严.疏理肝脾调畅气机法治疗中青年原发性高血压机制探讨[J].山东中医杂志,2004,23(5)：264-265.
[17]程志清.老年高血压病证治特点[J].浙江中医学院学报,1999,23(6)：14-15.
[18]王劲红.张国伦教授运用益气活血法治疗老年高血压病经验[J].河北中医,2006,18(4)：247.
[19]邓旭光.高血压病中西医结合的临床诊治的思路与方法[J].中医杂志,2000,41(2)：113-115.
[20]邹志东,刘宁,郭鹏,等.北京地区近10年高血压病中医用药规律分析[J].中国中药杂志,2007,32(15)：1569-1572
[21]刘德桓,林惠琴,王秀宝,等.化瘀浊益肝肾法对原发性高血压患者生活质量的 影响[J].中国临床康复,2006,10(23)：9-12.
[22]高雅琦,叶穗林,等.老年收缩期高血压中医证型与颈动脉硬化的临床研究[J].广州中医药大学学报,2008,25(5)：461-463.
[23]王长洪.著名中医学家董建华教授学术经验系列之三——从肝论治高血压病的经验[J].辽宁中医杂志,1999,26(9)：390.
[24]邱志济,朱建平,马璇卿.朱良春治疗高血压病用药经验特色选析——著名老中医学家朱良春教授临床经验(28)[J].辽宁中医杂志,2002,29(4)：194-195.
[25]刘福明,赵东杰,范群丽.唐蜀华教授治疗高血压病撷萃[J].江苏中医药,2002,23(6)：8-9.
[26]吴焕林,林晓忠.邓铁涛运用调脾法治疗高血压病的临床经验[J].中国中医基础医学杂志,2005,11(5)：400-401.
[27]徐健儿.周仲瑛运用温阳法辨治高血压病的经验[J].辽宁中医杂志,2001,28(5)：276-277
[28]王清海,李桂明,李典鸿.高血压病中医证型分布规律的临床研究.新中医,2005；37(11)：26-27
[29]刘小斌.邓铁涛教授“五脏相关”学术源流探讨.广州中医药大学学报,2006,23(5)：424-427.
[30]日本·山田业广.素问次注集疏[M].北京：学苑出版社,2004：451.
[31]马继兴.敦煌古医籍考释[M].南昌：江西科技出版社,1988：18.
[32]丛春雨.敦煌中医药全书[M].北京：中医古籍出版社,1994：117.
[33]日本·丹波元胤.中国医籍考[M].北京：人民卫生出版社,1983：180.
[34]明·李梃.医学入门[M].北京：中国中医药出版社,1995：72.
[35]徐志伟,刘小斌,邱仕君,郑洪等,中医“五脏相关”理论继承与创新的初步研究.广州中医药大学学报.2008.25(6)：475-479.
[36]田代华.五行学说是制约中医理论发展的关键因素.山东中医药大学学报,2006,30(2)：96-97.
[37]刘小斌,邱仕君,郑洪,等.邓铁涛“五脏相关”理论研究.中国中医基础医学杂志,2008,14(1)：20-22.
[38]陈凯佳.邓铁涛五脏相关理论研究的方法和思路探讨.中医研究,2006,19(4)：46-48.
[39]何梦瑶.医碥[M].上海：上海科学技术出版社,1982.3-9.
[40]刘小斌,刘友章.邓铁涛教授五脏相关学说略介.上海中医药杂志,2002.7：36-37.
[41]邓铁涛.邓铁涛医集[M].北京：人民卫生出版社,1995.1-2.
[42]王清海,卢桂梅,李爱华等.血压健胶囊对高血压患者左室重构逆转作用的临床研究.河南中医,1998；18(2)：34-35.
[43]黄琳,王清海,李典鸿等.复方芪麻胶囊对气虚痰浊型高血压患者动态血压的影响.中国试验方剂学杂志,2004；10(5)：57-58.
[44]江苏新医学院.中药大辞典.上海：上海科学技术出版社,1986,第一版：220-236.
[45]阴健,中药现代研究与临床应用[M].北京：中医古籍出版社,1995：32.
[46]陈宁,王清海,李爱华等.血压健4号治疗气虚痰浊型高血压临床观察.中西医结合心脑血管病杂志,2004；2(5)：255-256.
[47]韩学杰,张印生.冠心病痰瘀互结证的渊源和创新.中国医药学报,2004；19(10)：623-625.
[48]沈映君.中药药理学.上海：上海科学技术出版社,1997：50-52、59-60、90-91、149-150.
[49]White WB, Weber MA, Davidai G, etc.Ambulatory blood pressure monitoring in the primary care setting, assessment of therapy on the circadian variation of blood pressure from the MICCAT-2 trail Blood Pressure Monit,2005; 10 (3): 157-163.
[50]王丽先,李风原.高血压病患者动态血压负荷、昼夜节律改变与左室肥厚关系的研究.陕西医学杂志,2001；30(2)：85-86.
[51]邓冰湘,等高血压病患者血压昼夜节律与靶器官损害及中医证型关系的研究.湖南中医学院学报,2004,24(6)：48-49.
[52]黄琳,王清海,等.平肝胶囊治疗肝火亢盛型高血压临床观察.中国中医药信息杂志,2004,11(4)：334-335.
[53]姜坤,张兰华,刘玉芳等.龙胆泻肝汤加减治疗高血压病血液流变性的临床观察.中医药.2002,2：58.