切割穹窿海马伞大鼠海马内BLBP的表达变化
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摘要
目的:观察切割大鼠右侧穹窿海马伞后,切割侧与正常侧海马内脑脂结合蛋白(brain lipid binding protein, BLBP)的表达变化。方法:(1)半定量RT-PCR:36只SD大鼠随机分成6组,每组6只。1组为正常对照组,其余5组分别为切割右侧穹窿海马伞后1、3、5、7和14d组。取各组大鼠的海马组织,提取总RNA,采用半定量RT-PCR法分析右侧穹窿海马伞切割后海马内BLBP mRNA表达水平的变化。以各泳道中BLBP与GAPDH条带的光密度比值表示BLBP mRNA的相对表达量,使用Stata8.0统计学软件进行单因素方差分析和两两比较。(2)Western Blot: 36只SD大鼠随机分成6组,每组6只。1组为正常对照组,其余5组分别为切割右侧穹窿海马伞后1、3、5、7和14d组。取各组大鼠的海马组织,制备成提取液,进行SDS-PAGE、转膜,用BLBP多抗进行免疫印迹检测。对BLBP阳性条带和内参β-actin条带分别进行积分光密度分析,二者的积分光密度比值作为BLBP蛋白不同时相点的相对表达量,用Stata8.0统计软件进行单因素方差分析和组间比较。(3)免疫组织化学方法:36只SD大鼠随机分成6组,每组6只。1组为正常对照组,其余5组分别为切割右侧穹窿海马伞后1、3、5、7和14d组。各组大鼠灌注固定,取脑、冰冻切片,行BLBP免疫组织化学染色。每只动物海马的前、中、后各取1张切片共3张切片,每张切片对海马齿状回门区和颗粒下层0.075㎜ 2区域中的BLBP阳性细胞数和灰度值进行检测分析,应用Stata8.0统计软件进行配对t检验。结果:1.RT-PCR:正常组右侧海马内BLBP mRNA的相对表达量为0.057±0.019。切割后1d时表达量为0.065±0.013,3d(0.441±0.107)开始升高,5d(0.803±0.128)达到最高水平,7d(0.459±0.099)时开始下降,14d(0.082±0.016)时恢复至接近正常水平。统计学分析表明:切割后3d组、5d组、7d组与正常对照组相比较差异均有显著性意义(P<0.01),并且切割后5d组与3d组、7d组、14d组相比较差异有显著性意义(P <0.01)。2.Western Blot:BLBP相对表达量在切割后1d略升高(0.602±0.051),但与正常对照组(0.5714±0.085)相比无显著性意义(P>0.05),切割后3 d(1.151±0.078)继续升高,至切割后5 d(1.458±0.132)达到最高水平,切割后7 d(1.043±0.058)开始下降,切割后14 d(0.869±0.088)继续下降至接近正常水平。统计学分析表明:除切割后1d组外,其余切割后各d组与正常对照组相比较差异均有显著性意义(P均<0.01)。切割后各d组之间除3d组与7d组,7d组与14d组之间差异无显著性意义(P>0.05),其余各组间的差异均有显著性意义(P <0.01或=0.01)。3.免疫组织化学染色:正常大鼠双侧海马各区和齿状回中细胞仅有BLBP微量表达,切割穹窿海马伞后1 d两侧差异不明显;3 d时切割侧颗粒下层阳性细胞及染色深度较正常侧增多加深;5 d时切割侧颗粒下层阳性细胞数量明显增多,染色较深,胞体变大,突起增长,并达到最高水平;7 d后BLBP阳性细胞数量和染色深度开始降低,14d时接近正常侧水平。而切割后3 d、5 d时两侧门区BLBP阳性细胞的数量差异不大,但切割侧染色较深,7 d后也逐渐降低,14 d时降至正常侧水平。结论:切割穹窿海马伞后的海马组织中BLBP mRNA和蛋白的表达明显上调,其表达量呈现由低到高再逐渐恢复正常、切割后5d时表达量最高的时相性特点; BLBP阳性细胞主要位于切割侧和正常侧海马锥体细胞层和齿状回颗粒下层及门区中,切割侧表达强度明显高于正常侧;切割穹窿海马伞侧海马齿状回门区中的BLBP阳性放射状胶质细胞与正常侧相比未见明显增多,而颗粒下层中BLBP阳性的放射状胶质细胞明显增多,且胞体增大,突起变粗增长,呈现“激活”现象,提示其构成的支架不仅有助于神经干细胞的迁移,可能还与神经干细胞的分化有关。
Objective: To observe the change of the brain lipid binding protein (BLBP) expression in dentate gyrus(DG)region of transected and normal hippocampi after the right side of rats′fimbria-fornix transection. Methods: (1)RT-PCR: Thirty-six SD rats were randomly divided into 6 groups, 6 rats in each group. One group served as normal control and the others served as fimbria-fornix transected 1st, 3rd, 5th, 7th and 14th day group, respectively. Then hippocampi were isolated and total RNA was extracted. Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method was used in detection of the expression of BLBP mRNA in hippocampus after the right side of rats′fimbria-fornix transection. The relative expression level of BLBP mRNA was indicated by the ratio of the optical density value of BLBP to that of GAPDH. The Stata8.0 software was used in one-factor analysis of variance and comparison between every two groups. (2)Western Blot: Thirty-six SD rats were randomly divided into 6 groups, 6 rats in each group. One group served as normal control and the others served as fimbria-fornix transected 1st, 3rd, 5th, 7th and 14th day group, respectively. Then hippocampi were isolated and the extracts were gained from the fimbria-fornix transected and the normal hippocampi. The expression product of BLBP was detected by Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblot. The relative expression level of BLBP protein was indicated by the ratio of the integral optical density value of BLBP to that ofβ-actin. The Stata8.0 software was used for one-factor analysis of variance and comparison between every two groups. (3)Immunohistochemistry: Thirty-six SD rats were randomly divided into 6 groups, 6 rats in each group. One group served as normal control and the others served as fimbria-fornix transected 1st, 3rd, 5th, 7th and 14th day group, respectively. The rats were perfused and fixed, then cryostat sections of hippocampus were prepared for BLBP immunohistochemistry. Three sections were taken from each rat in first, middle and back hippocampus.The number and gray scale volume of BLBP positive cells in 0.075㎜ 2 aera of hilus and subgranular layer of dentate gyrus were measured, respectively. Paired t-test was used for the number and the gray scale volume of BLBP positive cells with Stata8.0 software. Results: (1)RT-PCR: In normal group, The relative expression level of BLBP mRNA was 0.057±0.019. On the 1st day, the expression level of BLBP mRNA was 0.065±0.013. It started to increase on the3rd day (0.256±0.54) after transection, and the peak appeared on the 5th day (0.719±0.124). Then it started to decrease on the 7th day(0.459±0.099)and closed to the normal level on the 14th day(0.082±0.016). Statistical analysis showed that there were not only statistically significant differences between the normal control group and the 3rd, 5th and 7th day group after transection (P<0.01), but also between the 5th day group and the 3rd, 7th and 14th day group after transection (P<0.01). (2)Western Blot: On the 1st day, the expression level of BLBP protein was 0.602±0.051, which appeared no statistically significant differences by comparing with the normal control group (P>0.05). It started to increase on the 3rd day (1.151±0.078) after transection, and the peak appeared on the 5th day (1.458±0.132). Then it started to decrease on the 7th day(1.043±0.058)and closed to the normal level on the 14th day(0.869±0.088). Statistical analysis showed that except the 1st day, there were statistically significant differences between all the other groups and the control group group (P<0.01); there were also statistically significant differences between each two groups (P<0.01 or =0.01), except between the 3rd day group and the 7th day group , between the 7th day and the 14th day (P>0.05). (3) Immunohistochemistry: The present results showed that few BLBP positive cells were expressed in both sides of each region and subgranular layer of hippocampus in control group. After the fimbria-fornix transection, no significant difference was observed in both sides on the 1st day. Compared with the normal side, more BLBP positive cells with deeper staining were found in the subgranular layer of the transected side on the 3rd day. The number and the color of the larger-body positive cells with growing neurite in subgranular layer of transected side were detected much more than those in normal side and appeared to the peak on the 5th day. Then it started to decrease 7 days later and closed to the normal level on the 14th day. But, the number of the BLBP positive cells showed little difference in both sides of hilus on the 3rd and 5th day after transection, while the color was more deeper in the fimbria-fornix transected side. Seven days later, it also decreased slowly and closed to pre-transection leve1 on the 14th day. Conclusion: The expression level of BLBP mRNA and protein increase after fimbria-fornix transection. The expression of BLBP mRNA and protein are changed with time, that is, those increase at first and then decrease to normal level, and reach peak on the 5th day. BLBP positive cells are expressed in pyramidal layer of hippocampus , subgranular layer and hilus of dentate gyrus in both sides, which are significantly higher in transected side than those in normal side; there are few increased BLBP-positive radial glial cells in hilus of fimbria-fornix transected side by compareing with the normal side, while BLBP-positive radial glial cells markedly increase in subgranular layer, the cell bodys become larger, and the processes grow longer, which show an "activation" phenomenon. The results suggest that the scaffolds of BLBP-positive radial glial cells might conduce to the neural stem cells migration and the differentiation to the neurons.
Objective: To observe the change of the brain lipid binding protein (BLBP) expression in dentate gyrus(DG)region of transected and normal hippocampi after the right side of rats′fimbria-fornix transection. Methods: (1)RT-PCR: Thirty-six SD rats were randomly divided into 6 groups, 6 rats in each group. One group served as normal control and the others served as fimbria-fornix transected 1st, 3rd, 5th, 7th and 14th day group, respectively. Then hippocampi were isolated and total RNA was extracted. Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method was used in detection of the expression of BLBP mRNA in hippocampus after the right side of rats′fimbria-fornix transection. The relative expression level of BLBP mRNA was indicated by the ratio of the optical density value of BLBP to that of GAPDH. The Stata8.0 software was used in one-factor analysis of variance and comparison between every two groups. (2)Western Blot: Thirty-six SD rats were randomly divided into 6 groups, 6 rats in each group. One group served as normal control and the others served as fimbria-fornix transected 1st, 3rd, 5th, 7th and 14th day group, respectively. Then hippocampi were isolated and the extracts were gained from the fimbria-fornix transected and the normal hippocampi. The expression product of BLBP was detected by Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblot. The relative expression level of BLBP protein was indicated by the ratio of the integral optical density value of BLBP to that ofβ-actin. The Stata8.0 software was used for one-factor analysis of variance and comparison between every two groups. (3)Immunohistochemistry: Thirty-six SD rats were randomly divided into 6 groups, 6 rats in each group. One group served as normal control and the others served as fimbria-fornix transected 1st, 3rd, 5th, 7th and 14th day group, respectively. The rats were perfused and fixed, then cryostat sections of hippocampus were prepared for BLBP immunohistochemistry. Three sections were taken from each rat in first, middle and back hippocampus.The number and gray scale volume of BLBP positive cells in 0.075㎜ 2 aera of hilus and subgranular layer of dentate gyrus were measured, respectively. Paired t-test was used for the number and the gray scale volume of BLBP positive cells with Stata8.0 software. Results: (1)RT-PCR: In normal group, The relative expression level of BLBP mRNA was 0.057±0.019. On the 1st day, the expression level of BLBP mRNA was 0.065±0.013. It started to increase on the3rd day (0.256±0.54) after transection, and the peak appeared on the 5th day (0.719±0.124). Then it started to decrease on the 7th day(0.459±0.099)and closed to the normal level on the 14th day(0.082±0.016). Statistical analysis showed that there were not only statistically significant differences between the normal control group and the 3rd, 5th and 7th day group after transection (P<0.01), but also between the 5th day group and the 3rd, 7th and 14th day group after transection (P<0.01). (2)Western Blot: On the 1st day, the expression level of BLBP protein was 0.602±0.051, which appeared no statistically significant differences by comparing with the normal control group (P>0.05). It started to increase on the 3rd day (1.151±0.078) after transection, and the peak appeared on the 5th day (1.458±0.132). Then it started to decrease on the 7th day(1.043±0.058)and closed to the normal level on the 14th day(0.869±0.088). Statistical analysis showed that except the 1st day, there were statistically significant differences between all the other groups and the control group group (P<0.01); there were also statistically significant differences between each two groups (P<0.01 or =0.01), except between the 3rd day group and the 7th day group , between the 7th day and the 14th day (P>0.05). (3) Immunohistochemistry: The present results showed that few BLBP positive cells were expressed in both sides of each region and subgranular layer of hippocampus in control group. After the fimbria-fornix transection, no significant difference was observed in both sides on the 1st day. Compared with the normal side, more BLBP positive cells with deeper staining were found in the subgranular layer of the transected side on the 3rd day. The number and the color of the larger-body positive cells with growing neurite in subgranular layer of transected side were detected much more than those in normal side and appeared to the peak on the 5th day. Then it started to decrease 7 days later and closed to the normal level on the 14th day. But, the number of the BLBP positive cells showed little difference in both sides of hilus on the 3rd and 5th day after transection, while the color was more deeper in the fimbria-fornix transected side. Seven days later, it also decreased slowly and closed to pre-transection leve1 on the 14th day. Conclusion: The expression level of BLBP mRNA and protein increase after fimbria-fornix transection. The expression of BLBP mRNA and protein are changed with time, that is, those increase at first and then decrease to normal level, and reach peak on the 5th day. BLBP positive cells are expressed in pyramidal layer of hippocampus , subgranular layer and hilus of dentate gyrus in both sides, which are significantly higher in transected side than those in normal side; there are few increased BLBP-positive radial glial cells in hilus of fimbria-fornix transected side by compareing with the normal side, while BLBP-positive radial glial cells markedly increase in subgranular layer, the cell bodys become larger, and the processes grow longer, which show an "activation" phenomenon. The results suggest that the scaffolds of BLBP-positive radial glial cells might conduce to the neural stem cells migration and the differentiation to the neurons.
引文
[1] Reynolds BA and Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science, 1992, 255(5052):1707-1710
[2] Gage FH. Mammalian neural stem cells. Science, 2000, 287(5457):1433-1438
[3] Akamatsu W and Okano H. Neural stem cell, as a source of graft material for transplantation in neuronal disease. No To Hattatsu, 2001, 33(2):114-120.
[4] Gage FH. Mammalian neural stem cells. Science, 2000, 287(5457): 1433-1438
[5] Ghashghaei HT, Weimer J M, Ralf S, et al. Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes & Dev, 2007, 21(24):3258-3271
[6] Barry D and McDermott K. Differentiation of radial glia from radial precursor cells and transformation into astrocytes in the developing rat spinal cord. Glia, 2005, 50(3):187-197
[7] Stettler EM and Galileo DS. Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain. J Comp Neurol, 2004, 468(3):441-451
[8] Gal JS, Morozov YM, Ayoub AE, et al. Molecular and Morphological Heterogeneity of Neural Precursors in the Mouse Neocortical Proliferative Zones. J Neurosci, 2006, 26(3):1045-1056
[9] Hartfuss E, F?rster E, Bock HH, et al. Reelin signaling directly affects radial glia morphology and biochemical maturation. Development, 2003, 130(19):4597-4609
[10] Mo ZC, Moore AR, Filipovic R, et al. Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci, 2008, 121(2):178-185
[11] Forster E, Tielsch A, Saum B, et al. Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial dial glial scaffold in the hippocampus. PNAS, 2002, 99(20):13178-13183
[12] Blaschke AJ, Staley K and Chun J. Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development, 1996, 122(4):1165-1174
[13] Hatten ME. LIS-less neurons don't even make it to the starting gate. J Cell Biol, 2005, 170(6):867-871
[14] Bagri A, Gurney T, He XP, et al. The chemokine SDF1 regulates migration of dentate granule cells. Development, 2002, 129(18):4249-4260
[15] Parnavelas JG and adarajah B. Radial glial cells. are they really glia? Neuron, 2001, 31(6):881-884
[16] Galichet C, Guillemot F and Parras CM. Neurogenin 2 has an essential role in development of the dentate gyrus. Development, 2008, 135(11):2031-2041
[17] Chakrabarti L, Galdzicki Z and Haydar TF. Defects in Embryonic Neurogenesis and Initial Synapse Formation in the Forebrain of the Ts65Dn Mouse Model of Down Syndrome. J Neurosci, 2007, 27(43): 11483-11495
[18] Galichet C, Guillemot F, Parras CM. Neurogenin 2 has an essential role in development of the dentate gyrus. Development, June 1, 2008, 135(11): 2031-2041
[19] Tung A, Herrera S, Fornal CA, et al. The Effect of Prolonged Anesthesia with Isoflurane, Propofol, Dexmedetomidine, or Ketamine on Neural Cell Proliferation in the Adult Rat. Anesth Analg, 2008, 106(6):1772-1777
[20] Sieber MA, Storm R, Martinez-de-la-Torre M, et al. Lbx1 Acts as a Selector Gene in the Fate Determination of Somatosensory and Viscerosensory Relay Neurons in the Hindbrain. J Neurosci, 2007, 27(18):4902-4909
[21] Kopan R and Turner DL. The Notch pathway: democracy and aristocracy in the selection of cell fate. Curr Opin Neurobiol, 1996, 6(5):594-601
[22] Leuner B, Gould E and Shors TJ. Is there a link between adult neurogenesis and learning? Hippocampus, 2006, 16(3):216-224
[23] Williams PA, Larimer P, Gao Y,et al. Semilunar Granule Cells: Glutamatergic Neurons in the Rat Dentate Gyrus with Axon Collaterals in the Inner Molecular Layer. J Neurosci, 2007, 27(50):13756-13761
[24] Fricker RA,Carpenter MK,Winkler C,et al. Site specific migration and neural differentiation of human neural progenitor cells after transplantation in the adult rat brain.J Neurosci, 1999, 19(14):5990-6005
[25]金国华,张新化,田美玲等.大鼠海马内移植神经干细胞的存活和迁移.神经解剖学杂志, 2003, 19(4):378-382
[26]张新化,金国华,秦建兵等.穹窿海马伞切割侧海马对植入神经干细胞分化为神经元的影响.神经解剖学杂志, 2004, 20(4):360-364
[27]金国华,张新化,田美玲等.穹窿海马伞切割侧海马提取液对神经干细胞分化为神经元的促进作用.解剖学报, 2004, 35(2):137-141
[28]朱蕙霞,秦建兵,田美玲等.切割海马伞海马中56 kD差异蛋白的质谱分析.南通大学学报(医学版) , 2006, 26(6): 408-413
[29]陈蓉,金国华,田美玲,等.海马中56KD蛋白诱导人神经干细胞迁移的作用.神经解剖学杂志, 2005; 21(4):372-376
[30] Anthony TE, Mason HA, Gridley T,et al. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev, 2005, 19(9):1028-1033
[31] Beneden KV, van Grunsven LA, Geers C,et al. CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis. Nephrol Dial. Transplant, 2008, 10:1093-1290
[32] Hunter KE and Hatten ME. Radial Glial Cell Transformation to Astrocytes is bidirectional: Regulation by a Diffusible Factor in Embryonic Forebrain. PNAS, 1995, 92(6):2061-2065
[33] Patten BA, Peyrin JM, Weinmaster G,et al. Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation. J Neurosci, 2003, 23(14):6132-6140
[34] Carneiro ?, Assun??o M, FreitasVD,et al. Red Wine, but not Port Wine, Protects Rat Hippocampal Dentate Gyrus Against Ethanol-Induced Neuronal Damage—Relevance of the Sugar Content. Alcohol Alcohol, 2008, 43(4):408-415
[35] Gasser UE and Hatten ME. Central Nervous System Neurons Migrate on Astroglial Fibers from Heterotypic Brain Regions in vitro. PNAS, 1990, 87(12):4543-4547
[36] Gasser UE and Hatten ME. Neuron-glia interactions of rat hippocampal cells in vitro: glial- guided neuronal migration and neuronal regulation of glial differentiation. J Neurosci, 1990, 10(4): 1276-1285
[37] Delaunay D, Heydon K, Cumano A, et al. Early Neuronal and Glial Fate Restriction ofEmbryonic Neural Stem Cells. J Neurosci, 2008, 28(10): 2551-2562
[38] Nadarajah B, Brunstrom JE, Grutzendler J, et al. Two modes of radial migration in early development of the cerebral cortex. Nat Neurosci, 2001, 4(2):143-150
[39] Shein HM. Propagation of human fetal spongioblasts and astrocytes in dispersed cell cultures. Exp Cell Res, 1965, 40(3):554-569
[40] Shibata T, Yamada K, Watanabe M, et al. Glutamate Transporter GLAST Is Expressed in the Radial Glia-Astrocyte Lineage of Developing Mouse Spinal Cord. J Neurosci, 1997, 17(23):9212-9219
[41] Zhicheng M, Anna R, Moore, et al. Human cortical neurons originate from radial glia and neuron-restricted progenitors. J Neurosci, 2007, 27(15):4132-4145
[42] Cai C, Thorne J and Grabel L. Hedgehog serves as a mitogen and survival factor during embryonic stem cell neurogenesis. Stem Cells, 2008, 26(5):1097-1108
[43] Murdoch B and Roskams AJ. A novel embryonic nestin-expressing radial glia-like progenitor gives rise to zonally restricted olfactory and vomeronasal neurons. J Neurosci, 2008, 28(16):4271-4282
[44] Noctor SC, Flint AC, Weissman TA, et al. Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia. J Neurosci, 2002, 22(8): 3161-3173
[45] Chang Yh, ?stling P, ?kerfelt M, et al. Role of heat-shock factor 2 in cerebral cortex formation and as a regulatorof p35 expression. Genes & Dev, 2006, 20(7):836-847
[46] Hartfuss E, Galli R, N Heins, et al. Characterization of CNS precursor subtypes and radial glia. Dev Biol, 2001, 229(1):15-30
[47] Kurtz A,Zimmer A,Schnutgen F,et al.The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development.Development,1994,120(9):2637-2649
[48]金国华,张新化,田美玲,等.大鼠海马内移植神经干细胞的存活和迁移.神经解剖学杂志, 2003; 19(4):378-382
[49]张新化,金国华,秦建兵,等.穹窿海马伞切割侧海马对植入神经干细胞分化为神经元的影响.神经解剖学杂志,2004;20(4):360-364
[50]金国华,张新化,田美玲,等.穹窿海马伞切割侧海马提取液对神经干细胞分化为神经元的促进作用.解剖学报, 2004;40(2):141-145
[51] Alvarez-Buylla A and García-Verdugo JM. Neurogenesis in adult subventricular zone. J Neurosci , 2002, 22(3):629-634
[52] Gaiano N and Fishell G. The role of notch in promoting glial and neural stem cell fates. Annu Rev Neurosci, 2002, 25:471-490
[53] Weissman T, Noctor SC, Clinton BK et al. Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration. Cereb Cortex, 2003, 13(6):550-559
[54] Noctor SC, Flint AC, Weissman TA et al. Neurons derived from radial glial cells establish radical units in neocortex. Nature, 2001, 409(6281):714-720
[1] Ghashghaei HT, Weimer J M, Ralf S, et al. Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes & Dev, 2007, 21(24):3258-3271
[2] Barry D and McDermott K. Differentiation of radial glia from radial precursor cells and transformation into astrocytes in the developing rat spinal cord. Glia, 2005, 50(3):187-197
[3] Kolliker AV and Turner WA. The minute anatomy of the spinal cord and cerebellum demonstrated by golgi's method. J Anat Physiol, 1891, 25(3):443-460
[4] Shein HM. Propagation of human fetal spongioblasts and astrocytes in dispersed cell cultures. Exp Cell Res, 1965, 40(3):554-569
[5] Roisen FJ, Klueber KM, Lu CL, et al. Adult human olfactory stem cells. Brain Res, 2001, 890(1):11-22
[6] Liour SS and Yu RK. Differentiation of radial glia-like cells from embryonic stem cells. Glia, 2003, 42(2):109-117
[7] Mokry J and Karbanova J. Foetal mouse neural stem cells give rise to ependymal cells in vitro. Folia Biol (Praha), 2006, 52(5):149-155
[8] Barrett P, Ivanova E, Graham ES, et al. Photoperiodic regulation of cellular retinoic acid-binding protein 1, GPR50 and nestin in tanycytes of the third ventricle ependymal layer of the siberian hamster. J Endocrinol, 2006, 191(3):687-698
[9] Gervasi C, Stewart CB and Szaro BG. Xenopus laevis peripherin (XIF3) is expressed in radial glia and proliferating neural epithelial cells as well as in neurons. J Comp Neurol, 2000, 423(3):512-531
[10] Flemstr?m G and Sj?blom M. Epithelial Cells and Their Neighbors. II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelial cells. Am J Physiol Gastrointest Liver Physiol, 2005, 289(3):377-380
[11] Gamble HJ. Axon ensheathing by ependymal cells in the human embryonic and foetal spinal cord. Nature, 1968, 218(5137): 182-183
[12] Delaunay D, Heydon K, Cumano A, et al. Early neuronal and glial fate restriction of embryonic neural stem cells. J Neurosci, 2008, 28(10):2551-2562
[13] Rakic P. Mode of cell migration to the superficial layers of fetal monkey neocortex. J Comp Neurol, 1972, 145(1):61-83
[14] Rakic P. Radial versus tangenital migration of neuronal clones in the developing cerebral cortex. PNAS, 1995, 92(25):11323-11327
[15] Dieudonne S. Glycinergic synaptic currents in golgi cells of the rat cerebellum. PNAS, 1995, 92(5):1441-1445
[16] Koenderink MJ and Uylings HB. Postnatal maturation of layer V pyramidal neurons in the human prefrontal cortex. A quantitative Golgi analysis. Brain Res, 1995, 678(1-2):233-243
[17] Murdoch B and Roskams AJ. A novel embryonic nestin-expressing radial glia-like progenitor gives rise to zonally restricted olfactory and vomeronasal neurons. J Neurosci, 2008, 28(16):4271-4282
[18] Zecevic N. Specific characteristic of radial glia in the human fetal telencephalon. Glia, 2004, 48(1): 27-35
[19] Elkabetz Y, Panagiotakos G, Shamy GA, et al. Human es cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes & Dev, 2008, 22(2):152-165
[20] Gal JS, Morozov YM, Ayoub AE, et al. Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. J Neurosci, 2006, 26(3):1045-1056
[21] Zhicheng M, Anna R, Moore, et al. Human cortical neurons originate from radial glia and neuron-restricted progenitors. J Neurosci, 2007, 27(15):4132-4145
[22] Cai C, Thorne J and Grabel L. Hedgehog serves as a mitogen and survival factor during embryonic stem cell neurogenesis. Stem Cells, 2008, 26(5):1097-1108
[23] Shapiro LA, Korn MJ, Shan Z, et al. GFAP-expressing radial glia-like cell bodies are involved in a one-to-one relationship with doublecortin-immunolabeled newborn neurons in the adult dentate gyrus. Brain Res, 2005, 1040(1-2):81-91
[24] Liu X, Bolteus AJ, Balkin DM, et al. GFAP-expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes. Glia, 2006, 54(5):394-410
[25] Borrell V, Kaspar BK, Gage FH, et al. In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. Cereb Cortex, 2006, 16(11):1571-1583
[26] Chang Yh, ?stling P, ?kerfelt M, et al. Role of heat-shock factor 2 in cerebral cortex formation and as a regulatorof p35 expression. Genes & Dev, 2006, 20(7):836-847
[27] Anthony TE, Mason HA, Gridley T, et al. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes & Dev, 2005, 19(1):1028-1033
[28] Shibata T, Yamada K, Watanabe M, et al. Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci, 1997, 17(23):9212-9219
[29] Yuasa S. Development of astrocytes in the mouse embryonic cerebrum tracked by tenascin-C gene expression. Arch Histol Cytol, 2001, 64(1):119-126
[30] Kulbatski I, Mothe AJ, Keating A, et al. Oligodendrocytes and radial glia derived from adult rat spinal cord progenitors: morphological and immunocytochemical characterization. J Histochem Cytochem, 2007, 55(3):209-222
[31] Doetsch F. The glial identity of neural stem cells. Nat Neurosci, 2003, 6(11):1127-1134
[32] Gotz M and HuttnerWB. The cell biology of neurogenesis. Nat Rev Mol Cell Biol, 2005, 6(10):777-788
[33] Kriegstein A and Parnavelas JG. Changing concepts of cortical development. Cereb Cortex, 2003, 13(6):541-541
[34] Costa MR, Kessaris N, Richardson WD, et al. The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex. J Neurosci, 2007, 27(42):11376-11388
[35] Voss AK, Britto JM, Dixon MP, et al. C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment. Development, 2008, 135(12):2139-2149
[36] Nadarajah B, Brunstrom JE, Grutzendler J, et al. Two modes of radial migration in earlydevelopment of the cerebral cortex. Nat Neurosci, 2001, 4(2):143-150
[37] Anda FC, G?rtner A, Tsai LH, et al. Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci, 2008, 121(2):178-185
[38] Huang H, Yamamoto A, Hossain MA, et al. Quantitative cortical mapping of fractional anisotropy in developing rat brains. J Neurosci, 2008, 28(26):1427-1433
[39] García-Moreno F, López-Mascaraque L and de Carlos JA. Early telencephalic migration topographically converging in the olfactory cortex. Cereb Cortex, 2008, 18(6):1239-1252
[40] Siegenthaler JA, Tremper-Wells BA, Miller MW, et al. Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression. Cereb Cortex, 2008, 18(8):1865-1875
[41] Johansen LD, Naumanen T, Knudsen A, et al. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci, 2008, 121(6):854-864
[42] Mo ZC, Moore AR, Filipovic R, et al. Human crtical nurons Originate from rdial gia and nuron-rstricted pogenitors. J Neurosci, 2007, 27(15):4132-4145.
[43] Stettler EM and Galileo DS. Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain. J Comp Neurol, 2004, 468(3):441-451.
[44] Gal JS, Morozov YM, Ayoub AE, et al. Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. J Neurosci, 2006, 26(3):1045-1056
[45] Hartfuss E, F?rster E, Bock HH, et al. Reelin signaling directly affects radial glia morphology and biochemical maturation. Development, 2003, 130(19):4597-4609
[46] Mo ZC, Moore AR, Filipovic R, et al. Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci, 2008, 121(2):178-185
[47] Hoffman S, Friedlander DR, Chuong CM, et al. Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions. J Cell Biol, 1986, 103(1):145-158
[48] Yoshimura S, Murray JI, Lu Y, et al. mls-2 and vab-3 control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans. Development, 2008, 135(13):2263-2275
[49] Anton ES, Kreidberg JA and Rakic P. Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex. Neuron, 1999, 22(2):277-289
[50] Schmid RS and Anton ES. Role of integrins in the development of the cerebral cortex. Cereb Cortex, 2003, 13(3):219-224
[51] Komuro H and Rakic P. Distinct modes of neuronal migration in different domains of developing cerebellar cortex. J Neurosci, 1998, 18(4):1478-1490
[52] Li H, Radford JC, Ragus MJ, et al. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. PNAS, 2008, 105(27):9397-9402
[53] Anton ES, Cameron RS and Rakic P. Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. J Neurosci, 1996, 16(7):2283-2293
[54] Hatten ME. New directions in neuronal migration. Science, 2002, 297(5587):1660-1663
[55] Patten BA, Peyrin JM, Weinmaster G, et al. Sequential signaling through notch1 and erbBreceptors mediates radial glia differentiation. J Neurosci, 2003, 23(14):6132-6140
[56] Rio C, Rieff HI, Qi P, et al. Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron, 1997, 19(1):39-50
[57] Schmid RS, McGrath B, Berechid BE, et al. Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. PNAS, 2003, 100(7):4251-4256
[58] Anton ES, Marchionni MA, Lee KF, et al. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development, 1997, 124(18): 3501-3510
[59] Zheng CH and Feng L. Neuregulin regulates the formation of radial glial scaffold in hippocampal dentate gyrus of postnatal rats. J Cell Physiol, 2006, 207(2):530-539
[60] Wexler EM, Berkovich O and Nawy S. Role of the low-affinity NGF receptor (p75) in survival of retinal bipolar cells. Vis Neurosci, 1998, 15(2):211-218
[61] Moya F and Valdeolmillos M. Polarized increase of calcium and nucleokinesis in tangentially migrating neurons. Cereb Cortex, 2004, 14(6):610-618
[62] D'Arcangelo G, Miao GG, Chen SC, et al. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature, 1995, 374(6524):719-723
[63] Kerjan G and Gleeson JG. A missed exit: Reelin sets in motion Dab1 polyubiquitination to put the break on neuronal migration. Genes & Dev, 2007, 21(21):2850-2854
[64] Forster E, Tielsch A, Saum B, et al. Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial dial glial scaffold in the hippocampus. PNAS, 2002, 99(20):13178-13183
[65] Luque JM, Morante-Oria J and Fairen A. Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. Brain Res Dev Brain Res, 2003, 140(2):195-203
[66] Fuchs E and Segre JA. Stem cells: a new lease on life. Cell, 2000, 100(1):143-155
[67] Anthony TE, Klein C, Fishell G, et al. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron, 2004, 41(6):881-890.
[68] Kondo T and Raff M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science, 2000, 289(5485):1754-1757
[69] Hartfuss E, Galli R, Heins N, et al. Characterization of CNS precursor subtypes and radial glia. Dev Biol, 2001, 229(1):15-30
[70] Malatesta P, Hartfuss E and Gotz M. Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development, 2000, 127(24):5253-5263
[71] Noctor SC, Flint AC, Weissman TA, et al. Neurons derived from radial glial cells establish radial units in neocortex. Nature, 2001, 409(6821):714-720
[72] Doetsch F, Caille I, Lim DA, et al. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell, 1999, 97(6):703-716.
[73] Laywell ED, Rakic P, Kukekov VG, et al. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. PNAS, 2000, 97(25):13883-13888
[74] Huang H, Yamamoto A, Hossain MA, et al. Quantitative cortical mapping of fractional anisotropy in developing rat brains. J Neurosci, 2008, 28(6):1427-1433
[75] Cameron RS and Rakic P. Identification of membrane proteins that comprise the plasmalemmal junction between migrating neurons and radial glial cells. J Neurosci, 1994,14(5 Pt 2):3139-3155
[76] Hartfuss E, Galli R, Heins N, et al. Characterization of CNS precursor subtypes and radial glia. Dev Biol, 2001, 229(1):15-30
[77] Noctor SC, Flint AC, Weissman TA, et al. Neurons derived from radial glial cells establish radial units in neocortex. Nature, 2001, 409(6821):714-720
[78] Noctor SC, Flint AC and Weissman TA. Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia. J Neurosci, 2002, 22(8):3161-3173
[79] Gotz M, Hartfuss E and Malatesta P. Radial glial cells as neuronal precursors: a new perspective on the correlation of morphology and lineage restriction in the developing cerebral cortex of mice. Brain Res Bull, 2002, 57(6):777-788
[80] Echeverri K and Tanaka EM. Ectoderm to mesoderm lineage switching during axolotl tail regeneration. Science, 2002; 298(5600):1993-1996
[81] Garcia-Verdugo JM, Ferron S, Flames N, et al. The proliferative ventricular zone in adult vertebrates: a comparative study using reptiles, birds, and mammals. Brain Res Bull, 2002, 57(6):765-775
[82] Sieber MA, Storm R, Martinez-de-la-Torre M, et al. Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain. J Neurosci, 2007,27(18):4902-4909
[83] Canoll PD, Kraemer R, Teng KK, et al. GGF/neuregulin induces a phenotypic reversion of oligodendrocytes. Mol Cell Neurosci, 1999, 13(2):79-94
[84] Calaora V, Rogister B, Bismuth K, et al. Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. J Neurosci, 2001, 21(13):4740-4751
[85] Lemmens, Doggen K and De Keulenaer G. Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure. Circulation, 2007, 116(8):954-960
[86] McCarthy M, Turnbull DH, Walsh C, et al. Telencephalic neural progenitors appear to be restricted to regional and glial fates before the onset of neurogenesis. J Neurosci, 2001, 21(17):6772-6781
[87] Rakic P. Elusive radial glial cells: historical and evolutionary perspective. Glia, 2003, 43(1):19-32
[88] Rompani SB and Cepko CL. Retinal progenitor cells can produce restricted subsets of horizontal cells. PNAS, 2008, 105(1):192-197
[89] Moe MC, Varghese M, Danilov AI, et al. Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons. Brain, 2005, 128(9):2189-2199
[90] Grove EA, Williams BP, Li DQ, et al. Multiple restricted lineages in the embryonic rat cerebral cortex. Development, 1993, 117(2):553-561
[91] Miyata T, Kawaguchi A, Okano H, et al. Asymmetric inheritance of radial glial fibers by cortical neurons. Neuron, 2001, 31(5):727-741
[92] Rakic P. Developmental and evolutionary adaptations of cortical radial glia. Cereb Cortex, 2003, 13(6):541-549
[93] Galichet C, Guillemot F and Parras CM. Neurogenin 2 has an essential role indevelopment of the dentate gyrus. Development, 2008, 135(11):2031-2041
[94] Frotscher M, Haas CA and F?rster E. Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold. Cereb Cortex, 2003, 13(6):634-640
[95] Zhou CJ, Zhao CJ and Pleasure SJ. Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities. J Neurosci, 2004, 24(1):121-126
[96] Wen Y, Planel E, Herman MJ, et al. Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3βmediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. Neurosci, 2008, 28(10):2624-2632
[97] Chang Q and Fischbach GD. An acute effect of neuregulin 1 to suppress 7-containing nicotinic acetylcholine receptors in hippocampal interneurons. J Neurosci, 2006, 26(44):11295-11303
[98] Maure P and Salzer JL. Axonal regulation of schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity. J Neurosci, 2000, 20(12):4635-4645
[99] Canoll PD, Musacchio JM, Hardy R, et al. GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Neuron, 1996, 17(2):229-243
[100] Sharif A, Legendre P, Prevot V, et al. Transforming growth factor alpha promotes sequential conversion of mature astrocytes into neural progenitors and stem cells. Oncogene, 2007, 26(19): 2695-2706
[101] Palomba L, Persichini T, Mazzone V, et al. Inhibition of Nitric-oxide Synthase-I (NOS-I)-dependent Nitric Oxide Production by Lipopolysaccharide plus Interferon-{gamma} Is Mediated by Arachidonic Acid: EFFECTS ON NF{kappa}B ACTIVATION AND LATE INDUCIBLE NOS EXPRESSIONJ. J Biol Chem, 2004, 279(29):29895-29901
[102] Girouard H, Lessard A, Capone C, et al. The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic. Am J Physiol Heart Circ Physiol, 2008, 294(1):156-163
[103] Koehler RC, Gebremedhin D and Harder DR. Role of astrocytes in cerebrovascular regulation. J Appl Physiol, 2006, 100(1):307-317
[104] Furukawa T, Mukherjee S, Bao ZZ, et al. rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells. Neuron, 2000, 26(2):383-394
[105] Fischer AJ and Reh TA. Müller glia are a potential source of neural regeneration in the postnatal chicken retina. Nat Neurosci, 2001, 4(3):247-252
[106] Hunter KE and Hatten ME. Radial glial cell transformation to astrocytes is bidirectional: regulation by a diffusible factor in embryonic forebrain. PNAS, 1995, 92(6):2061-2065
[107] Kopan R and Turner DL. The Notch pathway: democracy and aristocracy in the selection of cell fate. Curr Opin Neurobiol, 1996, 6(5):594-601
[108] Wang M and Sternberg PW. Competence and commitment of caenorhabditis elegans vulval precursor cells. Dev Biol, 1999, 212(1):12-24
[109] Coffman CR, Skoglund P, Harris WA, et al. Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell, 1993, 73(4):659-671
[110] Nye JS, Kopan R and Axel R. An activated Notch suppresses neurogenesis andmyogenesis but not gliogenesis in mammalian cells. Development, 1994, 120(9):2421-2430
[111] Wang S, Sdrulla AD, diSibio G, et al. Notch receptor activation inhibits oligodendrocyte differentiation. Neuron, 1998, 21(1):63-75
[112] Hojo M, Ohtsuka T, Hashimoto N, et al. Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. Development, 2000, 127(12):2515-2522
[113] Gaiano N, Nye JS and Fishell G. Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron, 2000, 26(2):395-404
[114] Morrison SJ, Perez SE, Qiao Z, et al. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell, 2000, 101(5):499-510
[115] Scheer N, Groth A, Hans S, et al. An instructive function for Notch in promoting gliogenesis in the zebrafish retina. Development, 2001, 128(7):1099-1107
[116] Lowell S. Stem cells: You make me feel so glial. Curr Biol, 2000, 10(16):595-597
[117] Wang S and Barres BA. Up a notch: instructing gliogenesis. Neuron, 2000, 27(2):197-200
[118] Schmid RS, McGrath B, Berechid BE, et al. Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. PNAS, 2003, 100(7):4251-4256
[119] Rio C, Rieff HI, Qi P, et al. Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron, 1997, 19(1):39-50
[120] Belvindrah R, Graus-Porta D, Goebbels S,et al. 1 Integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci, 2007, 27(50):13854-13865
[121] Gierdalski M, Sardi SP, Corfas G, et al. Endogenous neuregulin restores radial glia in a (Ferret) model of cortical dysplasia. J Neurosci, 2005, 25(37):8498-8504
[122] Williams PA, Larimer P, Gao Y, et al. Semilunar granule cells: glutamatergic neurons in the rat dentate gyrus with axon collaterals in the inner molecular layer. J Neurosci, 2007, 27(50):13756-13761
[123] Sunabori T, Tokunaga A, Nagai T, et al. Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors. J Cell Sci, 2008, 121(8):1204-1212
[124] Lyons DA, Pogoda HM, Voas MG, et al. erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish. Curr Biol, 2005, 15(6):513-524
[125] Park SK, Miller R, Krane I, et al. The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes. J Cell Biol, 2001, 154(6): 1245-1258
[126] Kim JY, Sun Q, Oglesbee M, et al. The role of erbB2 signaling in the onset of terminal differentiation of oligodendrocytes in vivo. J Neurosci, 2003, 23(6):5561-5571
[127] Zanazzi G, Einheber S, Westreich R, et al. Glial growth factor/neuregulin inhibits schwann cell myelination and induces demyelination. J Cell Biol, 2001, 152(6):1289-1299
[128] Sussman CR, Vartanian T and Miller RH. The erbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation. J Neurosci, 2005, 25(24):5757-5762
[129] Dong Z, Brennan A, Liu N, et al. Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Neuron,1995, 15(3):585-596
[130] Marchionni MA, Cannella B, Hoban C, et al. Neuregulin in neuron/glial interactions in the central nervous system. GGF2 diminishes autoimmune demyelination, promotes oligodendrocyte progenitor expansion, and enhances remyelination. Adv Exp Med Biol, 1999, 468:283-295
[131] Chakrabarti L, Galdzicki Z and Haydar TF. Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the ts65Dn mouse model of down syndrome. J Neurosci, 2007, 27(43):11483-11495
[132] Tung A, Herrera S, Fornal CA, et al. The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult rat. Anesth Analg, 2008, 106(6):1772-1777
[133] Williams PA, Larimer P, Gao Y, et al. Semilunar granule cells: glutamatergic neurons in the rat dentate gyrus with axon collaterals in the inner molecular layer. J Neurosci, 2007, 27(50):13756-13761
[134] Wadiche LO, Bromberg DA, Bensen AL, et al. GABAergic signaling to newborn neurons in dentate gyrus. J Neurophysiol, 2005, 94(6): 4528-4532.
[135] Lai C and Feng L. Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes. Biochem Biophys Res Commun, 2004, 314(2):535-542
[136] M??tt? JA, Sundvall M, Junttila TT, et al. Proteolytic cleavage and phosphorylation of a tumor-associated erbB4 isoform promote ligand-independent survival and cancer cell growth. Mol Biol Cell, 2006, 17(1):67-79
[137] Ni CY, Yuan HP, Carpenter G. Role of the erbB-4 carboxyl terminus in -secretase cleavage. J Biol Chem, 2003, 278(7):4561-4565
[138] Ni CY, Murphy MP, Golde TE, et al. -secretase ceavage and nuclear localization of erbB-4 receptor tyrosine kinase. Science, 2001, 294(5549):2179-2181
[139] Patten BA, Peyrin JM, Weinmaster G, et al. Sequential signaling through notch1 and erbB receptors mediates radial glia differentiation. J Neurosci, 2003, 23(14):6132-6140
[140] Shen Q, Zhong WM, Jan YN, et al. Asymmetric numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development, 2002, 129(20):4843-4853
[141] Zhong W, Jiang MM, Weinmaster G, et al. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development, 1997, 124(10):1887-1897
[2] Gage FH. Mammalian neural stem cells. Science, 2000, 287(5457):1433-1438
[3] Akamatsu W and Okano H. Neural stem cell, as a source of graft material for transplantation in neuronal disease. No To Hattatsu, 2001, 33(2):114-120.
[4] Gage FH. Mammalian neural stem cells. Science, 2000, 287(5457): 1433-1438
[5] Ghashghaei HT, Weimer J M, Ralf S, et al. Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes & Dev, 2007, 21(24):3258-3271
[6] Barry D and McDermott K. Differentiation of radial glia from radial precursor cells and transformation into astrocytes in the developing rat spinal cord. Glia, 2005, 50(3):187-197
[7] Stettler EM and Galileo DS. Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain. J Comp Neurol, 2004, 468(3):441-451
[8] Gal JS, Morozov YM, Ayoub AE, et al. Molecular and Morphological Heterogeneity of Neural Precursors in the Mouse Neocortical Proliferative Zones. J Neurosci, 2006, 26(3):1045-1056
[9] Hartfuss E, F?rster E, Bock HH, et al. Reelin signaling directly affects radial glia morphology and biochemical maturation. Development, 2003, 130(19):4597-4609
[10] Mo ZC, Moore AR, Filipovic R, et al. Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci, 2008, 121(2):178-185
[11] Forster E, Tielsch A, Saum B, et al. Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial dial glial scaffold in the hippocampus. PNAS, 2002, 99(20):13178-13183
[12] Blaschke AJ, Staley K and Chun J. Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development, 1996, 122(4):1165-1174
[13] Hatten ME. LIS-less neurons don't even make it to the starting gate. J Cell Biol, 2005, 170(6):867-871
[14] Bagri A, Gurney T, He XP, et al. The chemokine SDF1 regulates migration of dentate granule cells. Development, 2002, 129(18):4249-4260
[15] Parnavelas JG and adarajah B. Radial glial cells. are they really glia? Neuron, 2001, 31(6):881-884
[16] Galichet C, Guillemot F and Parras CM. Neurogenin 2 has an essential role in development of the dentate gyrus. Development, 2008, 135(11):2031-2041
[17] Chakrabarti L, Galdzicki Z and Haydar TF. Defects in Embryonic Neurogenesis and Initial Synapse Formation in the Forebrain of the Ts65Dn Mouse Model of Down Syndrome. J Neurosci, 2007, 27(43): 11483-11495
[18] Galichet C, Guillemot F, Parras CM. Neurogenin 2 has an essential role in development of the dentate gyrus. Development, June 1, 2008, 135(11): 2031-2041
[19] Tung A, Herrera S, Fornal CA, et al. The Effect of Prolonged Anesthesia with Isoflurane, Propofol, Dexmedetomidine, or Ketamine on Neural Cell Proliferation in the Adult Rat. Anesth Analg, 2008, 106(6):1772-1777
[20] Sieber MA, Storm R, Martinez-de-la-Torre M, et al. Lbx1 Acts as a Selector Gene in the Fate Determination of Somatosensory and Viscerosensory Relay Neurons in the Hindbrain. J Neurosci, 2007, 27(18):4902-4909
[21] Kopan R and Turner DL. The Notch pathway: democracy and aristocracy in the selection of cell fate. Curr Opin Neurobiol, 1996, 6(5):594-601
[22] Leuner B, Gould E and Shors TJ. Is there a link between adult neurogenesis and learning? Hippocampus, 2006, 16(3):216-224
[23] Williams PA, Larimer P, Gao Y,et al. Semilunar Granule Cells: Glutamatergic Neurons in the Rat Dentate Gyrus with Axon Collaterals in the Inner Molecular Layer. J Neurosci, 2007, 27(50):13756-13761
[24] Fricker RA,Carpenter MK,Winkler C,et al. Site specific migration and neural differentiation of human neural progenitor cells after transplantation in the adult rat brain.J Neurosci, 1999, 19(14):5990-6005
[25]金国华,张新化,田美玲等.大鼠海马内移植神经干细胞的存活和迁移.神经解剖学杂志, 2003, 19(4):378-382
[26]张新化,金国华,秦建兵等.穹窿海马伞切割侧海马对植入神经干细胞分化为神经元的影响.神经解剖学杂志, 2004, 20(4):360-364
[27]金国华,张新化,田美玲等.穹窿海马伞切割侧海马提取液对神经干细胞分化为神经元的促进作用.解剖学报, 2004, 35(2):137-141
[28]朱蕙霞,秦建兵,田美玲等.切割海马伞海马中56 kD差异蛋白的质谱分析.南通大学学报(医学版) , 2006, 26(6): 408-413
[29]陈蓉,金国华,田美玲,等.海马中56KD蛋白诱导人神经干细胞迁移的作用.神经解剖学杂志, 2005; 21(4):372-376
[30] Anthony TE, Mason HA, Gridley T,et al. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev, 2005, 19(9):1028-1033
[31] Beneden KV, van Grunsven LA, Geers C,et al. CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis. Nephrol Dial. Transplant, 2008, 10:1093-1290
[32] Hunter KE and Hatten ME. Radial Glial Cell Transformation to Astrocytes is bidirectional: Regulation by a Diffusible Factor in Embryonic Forebrain. PNAS, 1995, 92(6):2061-2065
[33] Patten BA, Peyrin JM, Weinmaster G,et al. Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation. J Neurosci, 2003, 23(14):6132-6140
[34] Carneiro ?, Assun??o M, FreitasVD,et al. Red Wine, but not Port Wine, Protects Rat Hippocampal Dentate Gyrus Against Ethanol-Induced Neuronal Damage—Relevance of the Sugar Content. Alcohol Alcohol, 2008, 43(4):408-415
[35] Gasser UE and Hatten ME. Central Nervous System Neurons Migrate on Astroglial Fibers from Heterotypic Brain Regions in vitro. PNAS, 1990, 87(12):4543-4547
[36] Gasser UE and Hatten ME. Neuron-glia interactions of rat hippocampal cells in vitro: glial- guided neuronal migration and neuronal regulation of glial differentiation. J Neurosci, 1990, 10(4): 1276-1285
[37] Delaunay D, Heydon K, Cumano A, et al. Early Neuronal and Glial Fate Restriction ofEmbryonic Neural Stem Cells. J Neurosci, 2008, 28(10): 2551-2562
[38] Nadarajah B, Brunstrom JE, Grutzendler J, et al. Two modes of radial migration in early development of the cerebral cortex. Nat Neurosci, 2001, 4(2):143-150
[39] Shein HM. Propagation of human fetal spongioblasts and astrocytes in dispersed cell cultures. Exp Cell Res, 1965, 40(3):554-569
[40] Shibata T, Yamada K, Watanabe M, et al. Glutamate Transporter GLAST Is Expressed in the Radial Glia-Astrocyte Lineage of Developing Mouse Spinal Cord. J Neurosci, 1997, 17(23):9212-9219
[41] Zhicheng M, Anna R, Moore, et al. Human cortical neurons originate from radial glia and neuron-restricted progenitors. J Neurosci, 2007, 27(15):4132-4145
[42] Cai C, Thorne J and Grabel L. Hedgehog serves as a mitogen and survival factor during embryonic stem cell neurogenesis. Stem Cells, 2008, 26(5):1097-1108
[43] Murdoch B and Roskams AJ. A novel embryonic nestin-expressing radial glia-like progenitor gives rise to zonally restricted olfactory and vomeronasal neurons. J Neurosci, 2008, 28(16):4271-4282
[44] Noctor SC, Flint AC, Weissman TA, et al. Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia. J Neurosci, 2002, 22(8): 3161-3173
[45] Chang Yh, ?stling P, ?kerfelt M, et al. Role of heat-shock factor 2 in cerebral cortex formation and as a regulatorof p35 expression. Genes & Dev, 2006, 20(7):836-847
[46] Hartfuss E, Galli R, N Heins, et al. Characterization of CNS precursor subtypes and radial glia. Dev Biol, 2001, 229(1):15-30
[47] Kurtz A,Zimmer A,Schnutgen F,et al.The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development.Development,1994,120(9):2637-2649
[48]金国华,张新化,田美玲,等.大鼠海马内移植神经干细胞的存活和迁移.神经解剖学杂志, 2003; 19(4):378-382
[49]张新化,金国华,秦建兵,等.穹窿海马伞切割侧海马对植入神经干细胞分化为神经元的影响.神经解剖学杂志,2004;20(4):360-364
[50]金国华,张新化,田美玲,等.穹窿海马伞切割侧海马提取液对神经干细胞分化为神经元的促进作用.解剖学报, 2004;40(2):141-145
[51] Alvarez-Buylla A and García-Verdugo JM. Neurogenesis in adult subventricular zone. J Neurosci , 2002, 22(3):629-634
[52] Gaiano N and Fishell G. The role of notch in promoting glial and neural stem cell fates. Annu Rev Neurosci, 2002, 25:471-490
[53] Weissman T, Noctor SC, Clinton BK et al. Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration. Cereb Cortex, 2003, 13(6):550-559
[54] Noctor SC, Flint AC, Weissman TA et al. Neurons derived from radial glial cells establish radical units in neocortex. Nature, 2001, 409(6281):714-720
[1] Ghashghaei HT, Weimer J M, Ralf S, et al. Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes & Dev, 2007, 21(24):3258-3271
[2] Barry D and McDermott K. Differentiation of radial glia from radial precursor cells and transformation into astrocytes in the developing rat spinal cord. Glia, 2005, 50(3):187-197
[3] Kolliker AV and Turner WA. The minute anatomy of the spinal cord and cerebellum demonstrated by golgi's method. J Anat Physiol, 1891, 25(3):443-460
[4] Shein HM. Propagation of human fetal spongioblasts and astrocytes in dispersed cell cultures. Exp Cell Res, 1965, 40(3):554-569
[5] Roisen FJ, Klueber KM, Lu CL, et al. Adult human olfactory stem cells. Brain Res, 2001, 890(1):11-22
[6] Liour SS and Yu RK. Differentiation of radial glia-like cells from embryonic stem cells. Glia, 2003, 42(2):109-117
[7] Mokry J and Karbanova J. Foetal mouse neural stem cells give rise to ependymal cells in vitro. Folia Biol (Praha), 2006, 52(5):149-155
[8] Barrett P, Ivanova E, Graham ES, et al. Photoperiodic regulation of cellular retinoic acid-binding protein 1, GPR50 and nestin in tanycytes of the third ventricle ependymal layer of the siberian hamster. J Endocrinol, 2006, 191(3):687-698
[9] Gervasi C, Stewart CB and Szaro BG. Xenopus laevis peripherin (XIF3) is expressed in radial glia and proliferating neural epithelial cells as well as in neurons. J Comp Neurol, 2000, 423(3):512-531
[10] Flemstr?m G and Sj?blom M. Epithelial Cells and Their Neighbors. II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelial cells. Am J Physiol Gastrointest Liver Physiol, 2005, 289(3):377-380
[11] Gamble HJ. Axon ensheathing by ependymal cells in the human embryonic and foetal spinal cord. Nature, 1968, 218(5137): 182-183
[12] Delaunay D, Heydon K, Cumano A, et al. Early neuronal and glial fate restriction of embryonic neural stem cells. J Neurosci, 2008, 28(10):2551-2562
[13] Rakic P. Mode of cell migration to the superficial layers of fetal monkey neocortex. J Comp Neurol, 1972, 145(1):61-83
[14] Rakic P. Radial versus tangenital migration of neuronal clones in the developing cerebral cortex. PNAS, 1995, 92(25):11323-11327
[15] Dieudonne S. Glycinergic synaptic currents in golgi cells of the rat cerebellum. PNAS, 1995, 92(5):1441-1445
[16] Koenderink MJ and Uylings HB. Postnatal maturation of layer V pyramidal neurons in the human prefrontal cortex. A quantitative Golgi analysis. Brain Res, 1995, 678(1-2):233-243
[17] Murdoch B and Roskams AJ. A novel embryonic nestin-expressing radial glia-like progenitor gives rise to zonally restricted olfactory and vomeronasal neurons. J Neurosci, 2008, 28(16):4271-4282
[18] Zecevic N. Specific characteristic of radial glia in the human fetal telencephalon. Glia, 2004, 48(1): 27-35
[19] Elkabetz Y, Panagiotakos G, Shamy GA, et al. Human es cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes & Dev, 2008, 22(2):152-165
[20] Gal JS, Morozov YM, Ayoub AE, et al. Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. J Neurosci, 2006, 26(3):1045-1056
[21] Zhicheng M, Anna R, Moore, et al. Human cortical neurons originate from radial glia and neuron-restricted progenitors. J Neurosci, 2007, 27(15):4132-4145
[22] Cai C, Thorne J and Grabel L. Hedgehog serves as a mitogen and survival factor during embryonic stem cell neurogenesis. Stem Cells, 2008, 26(5):1097-1108
[23] Shapiro LA, Korn MJ, Shan Z, et al. GFAP-expressing radial glia-like cell bodies are involved in a one-to-one relationship with doublecortin-immunolabeled newborn neurons in the adult dentate gyrus. Brain Res, 2005, 1040(1-2):81-91
[24] Liu X, Bolteus AJ, Balkin DM, et al. GFAP-expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes. Glia, 2006, 54(5):394-410
[25] Borrell V, Kaspar BK, Gage FH, et al. In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. Cereb Cortex, 2006, 16(11):1571-1583
[26] Chang Yh, ?stling P, ?kerfelt M, et al. Role of heat-shock factor 2 in cerebral cortex formation and as a regulatorof p35 expression. Genes & Dev, 2006, 20(7):836-847
[27] Anthony TE, Mason HA, Gridley T, et al. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes & Dev, 2005, 19(1):1028-1033
[28] Shibata T, Yamada K, Watanabe M, et al. Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci, 1997, 17(23):9212-9219
[29] Yuasa S. Development of astrocytes in the mouse embryonic cerebrum tracked by tenascin-C gene expression. Arch Histol Cytol, 2001, 64(1):119-126
[30] Kulbatski I, Mothe AJ, Keating A, et al. Oligodendrocytes and radial glia derived from adult rat spinal cord progenitors: morphological and immunocytochemical characterization. J Histochem Cytochem, 2007, 55(3):209-222
[31] Doetsch F. The glial identity of neural stem cells. Nat Neurosci, 2003, 6(11):1127-1134
[32] Gotz M and HuttnerWB. The cell biology of neurogenesis. Nat Rev Mol Cell Biol, 2005, 6(10):777-788
[33] Kriegstein A and Parnavelas JG. Changing concepts of cortical development. Cereb Cortex, 2003, 13(6):541-541
[34] Costa MR, Kessaris N, Richardson WD, et al. The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex. J Neurosci, 2007, 27(42):11376-11388
[35] Voss AK, Britto JM, Dixon MP, et al. C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment. Development, 2008, 135(12):2139-2149
[36] Nadarajah B, Brunstrom JE, Grutzendler J, et al. Two modes of radial migration in earlydevelopment of the cerebral cortex. Nat Neurosci, 2001, 4(2):143-150
[37] Anda FC, G?rtner A, Tsai LH, et al. Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci, 2008, 121(2):178-185
[38] Huang H, Yamamoto A, Hossain MA, et al. Quantitative cortical mapping of fractional anisotropy in developing rat brains. J Neurosci, 2008, 28(26):1427-1433
[39] García-Moreno F, López-Mascaraque L and de Carlos JA. Early telencephalic migration topographically converging in the olfactory cortex. Cereb Cortex, 2008, 18(6):1239-1252
[40] Siegenthaler JA, Tremper-Wells BA, Miller MW, et al. Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression. Cereb Cortex, 2008, 18(8):1865-1875
[41] Johansen LD, Naumanen T, Knudsen A, et al. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci, 2008, 121(6):854-864
[42] Mo ZC, Moore AR, Filipovic R, et al. Human crtical nurons Originate from rdial gia and nuron-rstricted pogenitors. J Neurosci, 2007, 27(15):4132-4145.
[43] Stettler EM and Galileo DS. Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain. J Comp Neurol, 2004, 468(3):441-451.
[44] Gal JS, Morozov YM, Ayoub AE, et al. Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. J Neurosci, 2006, 26(3):1045-1056
[45] Hartfuss E, F?rster E, Bock HH, et al. Reelin signaling directly affects radial glia morphology and biochemical maturation. Development, 2003, 130(19):4597-4609
[46] Mo ZC, Moore AR, Filipovic R, et al. Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci, 2008, 121(2):178-185
[47] Hoffman S, Friedlander DR, Chuong CM, et al. Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions. J Cell Biol, 1986, 103(1):145-158
[48] Yoshimura S, Murray JI, Lu Y, et al. mls-2 and vab-3 control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans. Development, 2008, 135(13):2263-2275
[49] Anton ES, Kreidberg JA and Rakic P. Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex. Neuron, 1999, 22(2):277-289
[50] Schmid RS and Anton ES. Role of integrins in the development of the cerebral cortex. Cereb Cortex, 2003, 13(3):219-224
[51] Komuro H and Rakic P. Distinct modes of neuronal migration in different domains of developing cerebellar cortex. J Neurosci, 1998, 18(4):1478-1490
[52] Li H, Radford JC, Ragus MJ, et al. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. PNAS, 2008, 105(27):9397-9402
[53] Anton ES, Cameron RS and Rakic P. Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. J Neurosci, 1996, 16(7):2283-2293
[54] Hatten ME. New directions in neuronal migration. Science, 2002, 297(5587):1660-1663
[55] Patten BA, Peyrin JM, Weinmaster G, et al. Sequential signaling through notch1 and erbBreceptors mediates radial glia differentiation. J Neurosci, 2003, 23(14):6132-6140
[56] Rio C, Rieff HI, Qi P, et al. Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron, 1997, 19(1):39-50
[57] Schmid RS, McGrath B, Berechid BE, et al. Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. PNAS, 2003, 100(7):4251-4256
[58] Anton ES, Marchionni MA, Lee KF, et al. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development, 1997, 124(18): 3501-3510
[59] Zheng CH and Feng L. Neuregulin regulates the formation of radial glial scaffold in hippocampal dentate gyrus of postnatal rats. J Cell Physiol, 2006, 207(2):530-539
[60] Wexler EM, Berkovich O and Nawy S. Role of the low-affinity NGF receptor (p75) in survival of retinal bipolar cells. Vis Neurosci, 1998, 15(2):211-218
[61] Moya F and Valdeolmillos M. Polarized increase of calcium and nucleokinesis in tangentially migrating neurons. Cereb Cortex, 2004, 14(6):610-618
[62] D'Arcangelo G, Miao GG, Chen SC, et al. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature, 1995, 374(6524):719-723
[63] Kerjan G and Gleeson JG. A missed exit: Reelin sets in motion Dab1 polyubiquitination to put the break on neuronal migration. Genes & Dev, 2007, 21(21):2850-2854
[64] Forster E, Tielsch A, Saum B, et al. Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial dial glial scaffold in the hippocampus. PNAS, 2002, 99(20):13178-13183
[65] Luque JM, Morante-Oria J and Fairen A. Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. Brain Res Dev Brain Res, 2003, 140(2):195-203
[66] Fuchs E and Segre JA. Stem cells: a new lease on life. Cell, 2000, 100(1):143-155
[67] Anthony TE, Klein C, Fishell G, et al. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron, 2004, 41(6):881-890.
[68] Kondo T and Raff M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science, 2000, 289(5485):1754-1757
[69] Hartfuss E, Galli R, Heins N, et al. Characterization of CNS precursor subtypes and radial glia. Dev Biol, 2001, 229(1):15-30
[70] Malatesta P, Hartfuss E and Gotz M. Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development, 2000, 127(24):5253-5263
[71] Noctor SC, Flint AC, Weissman TA, et al. Neurons derived from radial glial cells establish radial units in neocortex. Nature, 2001, 409(6821):714-720
[72] Doetsch F, Caille I, Lim DA, et al. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell, 1999, 97(6):703-716.
[73] Laywell ED, Rakic P, Kukekov VG, et al. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. PNAS, 2000, 97(25):13883-13888
[74] Huang H, Yamamoto A, Hossain MA, et al. Quantitative cortical mapping of fractional anisotropy in developing rat brains. J Neurosci, 2008, 28(6):1427-1433
[75] Cameron RS and Rakic P. Identification of membrane proteins that comprise the plasmalemmal junction between migrating neurons and radial glial cells. J Neurosci, 1994,14(5 Pt 2):3139-3155
[76] Hartfuss E, Galli R, Heins N, et al. Characterization of CNS precursor subtypes and radial glia. Dev Biol, 2001, 229(1):15-30
[77] Noctor SC, Flint AC, Weissman TA, et al. Neurons derived from radial glial cells establish radial units in neocortex. Nature, 2001, 409(6821):714-720
[78] Noctor SC, Flint AC and Weissman TA. Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia. J Neurosci, 2002, 22(8):3161-3173
[79] Gotz M, Hartfuss E and Malatesta P. Radial glial cells as neuronal precursors: a new perspective on the correlation of morphology and lineage restriction in the developing cerebral cortex of mice. Brain Res Bull, 2002, 57(6):777-788
[80] Echeverri K and Tanaka EM. Ectoderm to mesoderm lineage switching during axolotl tail regeneration. Science, 2002; 298(5600):1993-1996
[81] Garcia-Verdugo JM, Ferron S, Flames N, et al. The proliferative ventricular zone in adult vertebrates: a comparative study using reptiles, birds, and mammals. Brain Res Bull, 2002, 57(6):765-775
[82] Sieber MA, Storm R, Martinez-de-la-Torre M, et al. Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain. J Neurosci, 2007,27(18):4902-4909
[83] Canoll PD, Kraemer R, Teng KK, et al. GGF/neuregulin induces a phenotypic reversion of oligodendrocytes. Mol Cell Neurosci, 1999, 13(2):79-94
[84] Calaora V, Rogister B, Bismuth K, et al. Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. J Neurosci, 2001, 21(13):4740-4751
[85] Lemmens, Doggen K and De Keulenaer G. Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure. Circulation, 2007, 116(8):954-960
[86] McCarthy M, Turnbull DH, Walsh C, et al. Telencephalic neural progenitors appear to be restricted to regional and glial fates before the onset of neurogenesis. J Neurosci, 2001, 21(17):6772-6781
[87] Rakic P. Elusive radial glial cells: historical and evolutionary perspective. Glia, 2003, 43(1):19-32
[88] Rompani SB and Cepko CL. Retinal progenitor cells can produce restricted subsets of horizontal cells. PNAS, 2008, 105(1):192-197
[89] Moe MC, Varghese M, Danilov AI, et al. Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons. Brain, 2005, 128(9):2189-2199
[90] Grove EA, Williams BP, Li DQ, et al. Multiple restricted lineages in the embryonic rat cerebral cortex. Development, 1993, 117(2):553-561
[91] Miyata T, Kawaguchi A, Okano H, et al. Asymmetric inheritance of radial glial fibers by cortical neurons. Neuron, 2001, 31(5):727-741
[92] Rakic P. Developmental and evolutionary adaptations of cortical radial glia. Cereb Cortex, 2003, 13(6):541-549
[93] Galichet C, Guillemot F and Parras CM. Neurogenin 2 has an essential role indevelopment of the dentate gyrus. Development, 2008, 135(11):2031-2041
[94] Frotscher M, Haas CA and F?rster E. Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold. Cereb Cortex, 2003, 13(6):634-640
[95] Zhou CJ, Zhao CJ and Pleasure SJ. Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities. J Neurosci, 2004, 24(1):121-126
[96] Wen Y, Planel E, Herman MJ, et al. Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3βmediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. Neurosci, 2008, 28(10):2624-2632
[97] Chang Q and Fischbach GD. An acute effect of neuregulin 1 to suppress 7-containing nicotinic acetylcholine receptors in hippocampal interneurons. J Neurosci, 2006, 26(44):11295-11303
[98] Maure P and Salzer JL. Axonal regulation of schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity. J Neurosci, 2000, 20(12):4635-4645
[99] Canoll PD, Musacchio JM, Hardy R, et al. GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Neuron, 1996, 17(2):229-243
[100] Sharif A, Legendre P, Prevot V, et al. Transforming growth factor alpha promotes sequential conversion of mature astrocytes into neural progenitors and stem cells. Oncogene, 2007, 26(19): 2695-2706
[101] Palomba L, Persichini T, Mazzone V, et al. Inhibition of Nitric-oxide Synthase-I (NOS-I)-dependent Nitric Oxide Production by Lipopolysaccharide plus Interferon-{gamma} Is Mediated by Arachidonic Acid: EFFECTS ON NF{kappa}B ACTIVATION AND LATE INDUCIBLE NOS EXPRESSIONJ. J Biol Chem, 2004, 279(29):29895-29901
[102] Girouard H, Lessard A, Capone C, et al. The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic. Am J Physiol Heart Circ Physiol, 2008, 294(1):156-163
[103] Koehler RC, Gebremedhin D and Harder DR. Role of astrocytes in cerebrovascular regulation. J Appl Physiol, 2006, 100(1):307-317
[104] Furukawa T, Mukherjee S, Bao ZZ, et al. rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells. Neuron, 2000, 26(2):383-394
[105] Fischer AJ and Reh TA. Müller glia are a potential source of neural regeneration in the postnatal chicken retina. Nat Neurosci, 2001, 4(3):247-252
[106] Hunter KE and Hatten ME. Radial glial cell transformation to astrocytes is bidirectional: regulation by a diffusible factor in embryonic forebrain. PNAS, 1995, 92(6):2061-2065
[107] Kopan R and Turner DL. The Notch pathway: democracy and aristocracy in the selection of cell fate. Curr Opin Neurobiol, 1996, 6(5):594-601
[108] Wang M and Sternberg PW. Competence and commitment of caenorhabditis elegans vulval precursor cells. Dev Biol, 1999, 212(1):12-24
[109] Coffman CR, Skoglund P, Harris WA, et al. Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell, 1993, 73(4):659-671
[110] Nye JS, Kopan R and Axel R. An activated Notch suppresses neurogenesis andmyogenesis but not gliogenesis in mammalian cells. Development, 1994, 120(9):2421-2430
[111] Wang S, Sdrulla AD, diSibio G, et al. Notch receptor activation inhibits oligodendrocyte differentiation. Neuron, 1998, 21(1):63-75
[112] Hojo M, Ohtsuka T, Hashimoto N, et al. Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. Development, 2000, 127(12):2515-2522
[113] Gaiano N, Nye JS and Fishell G. Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron, 2000, 26(2):395-404
[114] Morrison SJ, Perez SE, Qiao Z, et al. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell, 2000, 101(5):499-510
[115] Scheer N, Groth A, Hans S, et al. An instructive function for Notch in promoting gliogenesis in the zebrafish retina. Development, 2001, 128(7):1099-1107
[116] Lowell S. Stem cells: You make me feel so glial. Curr Biol, 2000, 10(16):595-597
[117] Wang S and Barres BA. Up a notch: instructing gliogenesis. Neuron, 2000, 27(2):197-200
[118] Schmid RS, McGrath B, Berechid BE, et al. Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. PNAS, 2003, 100(7):4251-4256
[119] Rio C, Rieff HI, Qi P, et al. Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron, 1997, 19(1):39-50
[120] Belvindrah R, Graus-Porta D, Goebbels S,et al. 1 Integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex. J Neurosci, 2007, 27(50):13854-13865
[121] Gierdalski M, Sardi SP, Corfas G, et al. Endogenous neuregulin restores radial glia in a (Ferret) model of cortical dysplasia. J Neurosci, 2005, 25(37):8498-8504
[122] Williams PA, Larimer P, Gao Y, et al. Semilunar granule cells: glutamatergic neurons in the rat dentate gyrus with axon collaterals in the inner molecular layer. J Neurosci, 2007, 27(50):13756-13761
[123] Sunabori T, Tokunaga A, Nagai T, et al. Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors. J Cell Sci, 2008, 121(8):1204-1212
[124] Lyons DA, Pogoda HM, Voas MG, et al. erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish. Curr Biol, 2005, 15(6):513-524
[125] Park SK, Miller R, Krane I, et al. The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes. J Cell Biol, 2001, 154(6): 1245-1258
[126] Kim JY, Sun Q, Oglesbee M, et al. The role of erbB2 signaling in the onset of terminal differentiation of oligodendrocytes in vivo. J Neurosci, 2003, 23(6):5561-5571
[127] Zanazzi G, Einheber S, Westreich R, et al. Glial growth factor/neuregulin inhibits schwann cell myelination and induces demyelination. J Cell Biol, 2001, 152(6):1289-1299
[128] Sussman CR, Vartanian T and Miller RH. The erbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation. J Neurosci, 2005, 25(24):5757-5762
[129] Dong Z, Brennan A, Liu N, et al. Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Neuron,1995, 15(3):585-596
[130] Marchionni MA, Cannella B, Hoban C, et al. Neuregulin in neuron/glial interactions in the central nervous system. GGF2 diminishes autoimmune demyelination, promotes oligodendrocyte progenitor expansion, and enhances remyelination. Adv Exp Med Biol, 1999, 468:283-295
[131] Chakrabarti L, Galdzicki Z and Haydar TF. Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the ts65Dn mouse model of down syndrome. J Neurosci, 2007, 27(43):11483-11495
[132] Tung A, Herrera S, Fornal CA, et al. The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult rat. Anesth Analg, 2008, 106(6):1772-1777
[133] Williams PA, Larimer P, Gao Y, et al. Semilunar granule cells: glutamatergic neurons in the rat dentate gyrus with axon collaterals in the inner molecular layer. J Neurosci, 2007, 27(50):13756-13761
[134] Wadiche LO, Bromberg DA, Bensen AL, et al. GABAergic signaling to newborn neurons in dentate gyrus. J Neurophysiol, 2005, 94(6): 4528-4532.
[135] Lai C and Feng L. Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes. Biochem Biophys Res Commun, 2004, 314(2):535-542
[136] M??tt? JA, Sundvall M, Junttila TT, et al. Proteolytic cleavage and phosphorylation of a tumor-associated erbB4 isoform promote ligand-independent survival and cancer cell growth. Mol Biol Cell, 2006, 17(1):67-79
[137] Ni CY, Yuan HP, Carpenter G. Role of the erbB-4 carboxyl terminus in -secretase cleavage. J Biol Chem, 2003, 278(7):4561-4565
[138] Ni CY, Murphy MP, Golde TE, et al. -secretase ceavage and nuclear localization of erbB-4 receptor tyrosine kinase. Science, 2001, 294(5549):2179-2181
[139] Patten BA, Peyrin JM, Weinmaster G, et al. Sequential signaling through notch1 and erbB receptors mediates radial glia differentiation. J Neurosci, 2003, 23(14):6132-6140
[140] Shen Q, Zhong WM, Jan YN, et al. Asymmetric numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development, 2002, 129(20):4843-4853
[141] Zhong W, Jiang MM, Weinmaster G, et al. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development, 1997, 124(10):1887-1897