摘要
目的:本文在综述了慢性盆腔炎古今研究概况的基础上,研究炎克宁V号治疗慢性盆腔炎的作用机制。
研究方法:采用慢性盆腔炎的常见致病菌——大肠杆菌、金黄色葡萄球菌、乙型溶血性链球菌成功的制作了慢性盆腔炎大鼠模型,将大鼠模型随机分为正常组、假手术组、模型组、炎克宁V号高、中、低剂量组和中药对照组。分别应用光镜和电镜方法对各组大鼠子宫组织进行形态学观察;应用免疫组织化学反应法检测各组大鼠子宫组织中NF-κB、Bax和ICAM-1的表达;应用酶联免疫吸附测定(ELISA)法检测各组大鼠血清中TNF-α和IL-10含量;黄嘌呤氧化酶法检测血清中SOD含量;应用逆转录聚合酶链式反应(RT-PCR)法检测各组大鼠子宫组织INF-γmRNA、NF-κBmRNA和ICAM-1 mRNA的表达。
结果:炎克宁V号各组与模型组比较能明显减轻子宫粘膜充血、水肿、炎性渗出及粘连,促进组织修复。其中炎克宁V号中、低剂量组优于中药对照组(P<0.05);炎克宁V号中剂量组NF-κB、Bax和ICAM-1表达与模型组、高剂量组和中药对照组有显著性差异(P<0.05);炎克宁V号明显减弱了INF-γmRNA、NF-κBmRNA和ICAM-1 mRNA在子宫组织中的表达(P<0.05);炎克宁V号中、低剂量组血清中TNF-α和IL-10含量明显低于模型组、高剂量组和中药对照组(P<0.05);炎克宁V号中剂量组血清中SOD含量明显高于模型组、炎克宁V号高剂量组和中药对照组(P<0.05)。
结论:通过本实验说明炎克宁V号能明显减轻组织充血、水肿、炎性渗出及粘连,促进组织修复;炎克宁V号能明显降低NF-κB及其下游产物ICAM-1、TNF-α、L-10、INF-γ的水平;炎克宁V号能够促进子宫组织Bax表达,从而促进炎症细胞的凋亡;炎克宁V号能够通过增加SOD活性,加快清除氧自由基;炎克宁V号可能通过抑制NF-κB及炎性介质、促进炎细胞的凋亡及氧自由基的清除,有利于慢性盆腔炎症的消除。炎克宁V号方是治疗慢性盆腔炎的有效方剂。
Objective:
The researeh was studied in having summed up the chronic pelvicinflammatory disease(CPID)forth on the basis to study a general situationfrom ancient times to modern times,the purpose was to explore theYankeNing V curing CPID effect mechanism.
Methods:
Adopt chronic common CPID pathogenic bacteria-bacillus coli,staphylococcus aureus,hemolysis streptococcus B to have establish the CPIDrats model.Successfully.Female Wistar rats were randomly classified intothe following different groups:the normal group,the simulative modelgroup,the model group,the high dose of YankeNingVgroup,the mediumdose of YankeNing V group,the low dose of YankeNing V group and thecontrol group of Chinese medieine.Applied glossy microscope and electronmicroscope respectively to detect the ultrastruetural changes of uterus ofevery group rats.The expressiom ofBax,NF-KB and ICAM-1 was detectedwith the method of immunohistochemistry.The content of TNF-a and IL-10of serum was detected with the method of ELISA and the content of SOD inserum was detected with the method of xanthine oxidase.The expressiom ofINF-γmRNA,NF-κB mRNA和ICAM-1 mRNA in uterus was by RT-PCR.
Results:
Compared with the model group,the three YankeNing V groups canobviously relieve hyperemia,edema and adherence,and accelerate therecovery of the tissues.The effete of the low dose of YankeNing V group andthe medium dose of YankeNing V group were superior to the control group ofChinese medicine(p<0.05);The expressiom of Bax,NF-κB and ICAM-lin themedium dose of the YankeNing V groupe had notable difference with themodel group,the high dose group of the YankeNing V and the control groupof Chinesemedicine(p<0.05);The YankeNingVgroupe obviously decreased the expression of NF-KB and ICAM-1 mRNA(p<0.05);The contents ofTNF-a,IL-10 of the low dose of YankeNing V group and the medium dose oftheYankeNing V in serum was obviously lower than the model group,thehigh dose group of YankeNing V group and the control group of Chinesemedieine group (P<0.05);The contents of SOD of the medium dose oftheYankeNing V in serum was significantly better than the model group,thehigh dose group of YankeNing V group and the control group of Chinesemedieine group (P<0.05).
Conc IU sions:
Through this experiment,we can have the explainions:the YankeNing Vrelieve hyperemia,edema and adherence,and accelerate recovery of thetissues;The YankeNing V can obviously decrease NF-κB and its down streamproducts(ICAM-l,TNF-a,L-10,INF-γ);The YankeNing V can promote theexpression of Bax,and promote apoptosis of inflammatory cell;TheYankeNing V increase the aetivity of SOD,and aceelerate clearningoXradical;The YankeNing V treats CPID by inhibiting NF-κB and the relevantinflammatory medium,promoting apoptosis inflammatory cell and cleaningoxygen radical.The research has improved that the defined formula-Yankening V was effective when treating the common gynecologicaldisease-chronic pelvic inflammataotry disease (CPID).The YankeNingVisthe effective prescription for curing CPID.
引文
1.王淑贞主编.《妇产科学》.高等医药院校试用教材(第一版)[M].北京:人民卫生出版社1963
2.乐杰主编.《妇产科学》.高等医药院校教材(第五版)[M].北京:人民卫生出版社1980
3.马宝璋主编.《中医妇科学》.高等教育中医药类规划教材(第六版)[M].上海:上海科学技术出版社1997
4.马宝璋主编.《中医妇科学》.高等中医药院校七年制规划教材(第一版)[M].北京:中国中医药出版社2004
5.Washington AE,katz P.Gost of and payment Source for pelvir inflammatory disease trends and Proiections.1983 through 2000.JAMA 1991;266:2565-2569
6.PcterA Rice.MD Julius Schachter.PhD.[J]美国医学会杂志中文版1992年8月(11)4:195-202
7.王树林.[D]黑龙江中医药大学博士学位论文1994
8.《皇帝内经素问》[M].北京:人民卫生出版社1963
9.《灵枢经》[M].北京:人民卫生出版社1963
10.汉·张仲景著.《金匱要略方论》[M].北京:人民卫生出版社影印1956
11.晋·王叔和著.《脉经》[M].北京:人民卫生出版社影印1956
12.隋·巢元方等著.《诸病源候论》[M].北京:人民卫生出版社影印1955
13.唐·孙思邈著.《备急千金要方》[M].北京:人民卫生出版社影印1955
14.宋·陈自明撰.《妇人大全良方》[M].北京:人民卫生出版社1985
15.金·刘完素著.《素问病机气宜保命集》[M].北京:中医古籍出版社1981
16.金·张子和著.《儒门事亲》[M].上海:上海科学技术出版社1959
17.金·李杲所著.《兰室秘藏》[M].北京:人民卫生出版社影印1957
18.元·朱震亨著.《丹溪心法》[M].上海:上海科学技术出版社1959
19.明·陈文昭著.《陈素庵妇科补解》[M].上海:上海科学技术出版社1983
20.明·万全著.《万氏妇人科》[M]武汉:湖北人民出版社1983
21.明·王肯堂著.《证治准绳》[M].上海:上海科学技术出版社1959
22.明·张介宾著.《景岳全书》[M].上海:上海科学技术出版社1959
23.清·傅山.《傅青主女科》[M].上海:上海人民出版社1978
24.清·武之望著.《济阴纲目》[M],上海:上海科学技术出版社1958
25.清·王清任著.《医林改错》[M].上海:上海卫生出版社1956
26.清·葉天士著.《临证指南医案》[M].上海:上海科学技术出版社1959
27.清沈尧封著,张山雷笺正.《沈氏女科辑要笺正》[M].上海:上海卫生出版社1958
28.民国·张锡纯著.《医学衷中参西录》[M]石家庄:河北人民出版社1957
29.罗显民,丹芍皂角刺汤治疗慢性盆腔炎60例临床观察[J].吉林中医药,1998,18(4):30
30.郑红姝,活血化淤为主治疗慢性盆腔炎58例[J].广西中医药,1998,21(2):15-16
31.刘秀宁,当归元胡汤治疗慢性盆腔炎112例[J].中西医结合杂志,1994,14(3):178
32.马淑兰,庞学成.自拟方治疗慢性盆腔炎54例临床观察[J].辽宁中医杂志,1995,22(8):366
33.卢苏,红藤败酱散治疗盆腔炎行包块34例[J].山东中医杂志,1995.14(7):301
34.刘奉五.《刘奉五妇科经验》[M].北京:人民卫生出版社,第1版,1997,290
35.武俊.少腹逐瘀汤加减治疗慢性盆腔炎101例临床观察[J].中医药管理杂志,2006,14 (8):64
36.毛美蓉,陈诗亮,慢性盆腔炎分型论治[J].湖北中医杂志,1996;(1):43.
37.邱秋华,盆腔炎的分型与论治[J].江西中医药,1994;(3):36
38.陈朋秋.当归芍药散加味治疗慢性盆腔炎[J].吉林中医药,2000,3:27
39.张春贤,石洪.当归芍药散治疗慢性盆腔炎43例[J].长江大学学报(自科版),20063 (2):252
40.张娟,张仁义.当归芍药散治疗慢性盆腔炎86例观察[J].实用中医药杂志,2006 22(9):541
41.王娟娟,孙治东.加味当归芍药散治疗慢性盆腔炎56例[J].山西中医,2003,19(2):26
42.桑希生,姜琪,王志国等.当归芍药散治疗慢性盆腔炎85例临床观察[J].中医药学报,1999,1 1(4):29-30
43.李虹,冯俊婵.当归芍药散加味治疗慢性盆腔炎100例疗效观察[J].山西中医学院学报,2000,1(1):21-22
44.王雪敏,李俊芳,赵玲玲.加味桂枝茯苓汤治疗慢性盆腔炎80例[J].山东中医杂志, 2002,21(1):28-30
45.张玉卿.桂枝茯苓胶囊配合抗生素治疗慢性盆腔炎临床观察[J].湖北中医杂志,2006,28(11):45
46.江琳.桂枝茯苓丸加减治疗慢性盆腔炎所致继发性不孕症40例[J].安徽中医临床杂志,2002,14(4):179
47.申学永,王红霞.加味桂枝茯苓丸治疗慢性盆腔炎76例[J].中医药临床杂志,2004, 16(3):234-235
48.白玉章,杜烨.桂枝茯苓丸加味治疗慢性盆腔炎50例[J].陕西中医,2002,23(5):438
49.季蒋晖.季光运用薏苡附子败酱散临床经验撷菁[J].江苏中医药,2006 ,27(12):10
50.施燕.苡仁附子败酱散治疗慢性盆腔炎98例[J].实用中医药杂志,2001,17(9):14-15
51.申伟平.妇炎合剂治疗慢性盆腔炎306例[J].中医研究,2003,16(6):33-34
52.严宇仙.大黄牡丹汤合金铃子散加减治疗慢性盆腔炎40例[J].河北中医,2000,22 (5):371
53.杨世勤,王惠东,王玉玺.大黄牡丹皮汤加减治疗慢性盆腔炎177例疗效观察[J].甘肃中医,1998,1 1(6):27-28
54.王玉霞.金匮大黄牡丹汤治疗急慢性盆腔炎的临床观察[J].中医药信息,1999, 6:41-42
55.朱惠云.血府逐瘀汤加味治疗慢性盆腔炎160例[J].辽宁中医药大学学报,2007,9(1):91
56.吴燕琼.少腹逐瘀汤化裁治疗慢性盆腔炎40例[J].四川中医,2003,21(9):58-59
57.武俊.少腹逐瘀汤加减治疗慢性盆腔炎101例临床观察[J].中医药管理杂志,2006,14 (8):64
58.吴难.少腹逐瘀汤治疗慢性盆腔炎21例[J].南京中医药大学学报,1997,13(1):49-50
59.郭玲,郭宏宇,徐金英等.血府逐瘀胶囊治疗慢性盆腔炎17例[J].北京中医杂志,2002, 21(3):192-193
60.姜晓成.少腹逐瘀汤加减治疗慢性盆腔炎60例[J].吉林中医药,2001,5:31
61.李永根,马建强.少腹逐瘀汤加减治疗慢性盆腔炎63例[J].浙江中西医结合杂志, 2001,11(10):654-655
62.陈萍,李灵芝,李桂华.加味易黄汤治疗慢性盆腔炎疗效观察[J].四川中医,2003, 21(7):57-58
63.王嘉梅.补中益气汤治疗慢性盆腔炎86例[J].陕西中医,2002,23(5):417
64.麦建红.八正散治疗急、慢性盆腔炎47例[J].云南中医中药杂志,2000,21(6):12-14
65.李春华.五味消毒饮加味治疗慢性盆腔炎46例[J].宜春医专学报, 2001,13(2):199
66.肖元玲,郑晶.五积散化裁治疗慢性盆腔炎80例[J].吉林中医药,2002,22(1):27
67.梅本华.阳和汤在妇科疾病中运用体会[J].上海中医药杂志,2006,40 (11)3 7
68.赵文妍,陈荣.十枣汤新用[J].新中医,2006,38(10):85
69.司秋荣,宋彤云.四逆散加味治疗慢性盆腔炎86例[J].中医临床选萃,2006,22(4):44
70.纪伦.妇乐胶囊治疗慢性盆腔炎90例临床观察[J].黑龙江医药,2004,28(2):140
71.杨华,邬晋芳.妇乐冲剂为主治疗输卵管不通51例[J].陕西中医,2001,22(6):344
72.王慧琴,金刚藤糖浆治疗妇科炎症500例观察[J].甘肃科技,2000, 16(1):56
73.崔梅芳,金刚藤糖浆治疗盆腔炎120例疗效观察[J].现代中西医结合杂志,2001, 10(6):515
74.唐桥莉.金刚藤胶囊配伍抗生素联合用药治疗女性盆腔炎疗效观察[J].中国现代应用药学杂志,2006,23(8):841
75.王慧琴.金刚藤糖浆治疗妇科炎症500例观察[J].甘肃科技,2000,16(1):56
76.张淑杰,王春芳.金刚藤糖浆治疗慢性盆腔炎56例[J].中国医药学报,2002, 17(8):509
77.魏光萍.金刚藤治疗慢性盆腔炎疗效观察[J].现代中西医结合杂志,2004,16(4):5
78.潘春荣,刘鸣舞,赵文荣.金刚藤糖浆治疗慢性盆腔炎100例临床观察[J].哈尔滨医药,2002,22(1):62
79.魏绍斌,谢平.金刚藤片治疗慢性盆腔炎临床观察[J].中药药理与临床,2002, 18(5):125
80.胡青慧,安源.金刚藤胶囊治疗慢性盆腔炎疗效观察[J].西南国防医药,2001, 11(4):294-295
81.戴庆玲.妇科千金片治疗慢性盆腔炎106例临床观察[J].湖南中医杂志,2000, 16(5):41-42
82.柴惠霞.妇科千金片治疗慢性盆腔炎60例观察[J].现代中西医结合杂,2002, 11 (3):244
83.冯国湘,朱月英,左之文.妇科千金胶囊治疗慢性盆腔炎的疗效观察[J].现代中西医结合杂志,2002,1 1(18):1760-1761
84.王如高,杜玉娟.妇科千金片治疗慢性盆腔炎80例[J].湖南中医杂志,1999,15(6):53-54
85.黄月琴,叶青芸,陈祥凤等.妇科千金片治疗慢性盆腔炎53例[J].现代中西医结合杂志,2000,9(14):1323-1324
86.胡小荣,周士源.妇科千金胶囊治疗慢性盆腔炎48例疗效观察[J].中国医师杂志,2004,16(7):241
87.黄丽珍,张军.妇科千金胶囊治疗慢性盆腔炎60例临床疗效观察[J].中华实用中西医杂志,2004,4(17):507
88.李迪,孙庆娥,抗宫炎片治疗妇科慢性炎症393例[J].陕西中医,2001,22(12): 719
89.彭翠娟,三金片治疗慢性盆腔炎的体会[J].工企医刊,2003, 16 (2 ): 42
90.戚刚,择时口服金鸡片治疗慢性子宫内膜炎80例疗效观察[J].中国全科医学,2003,6 (2):7
91.章勤,何少山.芪竭颗粒对慢性盆腔炎患者细胞免疫功能影响的研究[J].四川中医,2003,21(4):53
92.章勤,何嘉琳,宋晓玲.芪竭颗粒治疗慢性盆腔炎的实验研究[J].中国中医药科技,2002,9(6):337
93.张敦兰,金志春,谭宫屏等.盆腔舒胶囊抗炎镇痛作用及对子宫收缩影响[J].医药导报,2004,23 (7):446-449
94.金志春,张敦兰,李倬珍等.盆腔舒胶囊治疗慢性盆腔炎的临床研究[J].中华实用中西医杂志,2004,4(17):687-691
95.金志春,张敦兰,谭宫屏.盆腔舒胶囊治疗慢性盆腔炎的药效学研究[J].上海中医药大学学报,2002,16(1):56-58
96.胡琳.宫炎平片治疗急慢性盆腔炎100例[J].陕西中医,2001,22(6):334
97.杨玲.玉清抗宫炎片合并康妇消炎栓治疗慢性盆腔炎146例[J].观察社区医学杂志,2006,(30)18:16
98.孙晖,王梁爽.玉清抗宫炎片治疗慢性盆腔炎162例[J].国医论坛,2004,19(2):32
99.张光贤,胡航辉,胡丽娜.玉清抗宫炎片治疗慢性盆腔炎临床观察小结[J].湖南中医 药导报,2001,7(6):310-311
100.宋红湘,王素萍,张建新.妇炎康泰冲剂治疗慢性盆腔炎的临床观察[J].中医研究,1997,10(2):46-47
101.宋红湘,庆慧,李淑敏等.妇炎康泰冲剂治疗慢性盆腔炎的实验研究[J].中国中医药科技,1998,5(5):290-291
102.马锡敏,周志杰,张亮.花蛇利腹片治疗慢性盆腔炎320例[J].吉林中医药,2003,23(7):25
103.陈清秀,杨家林.妇康口服液治疗慢性盆腔炎的临床疗效观察[J].成都中医药大学学报,2003,26(3):27-29
104.刘瑞芬.盆腔炎颗粒治疗慢性盆腔炎的临床与实验研究[J].山东中医药大学学报,2003,16(6):12
105.陈惠铮,王桂媛.妇炎宁颗粒剂治疗盆腔炎100例临床观察[J].中医药学报,2003,31(2):44-45
106.苏华林,陈静会,林华.盆腔消炎胶囊治疗慢性盆腔炎临床观察[J].四川中医,2003,21(10):59-60
107.侯雁.天紫红女金胶囊治疗慢性盆腔炎30例临床观察[J].北京中医杂志,2003,22 (2):62-63
108.罗元恺,盆腔炎的中医药治疗[J].新中医,1993,(3):17
109.王晓云,夏桂成用调周法治疗慢性盆腔炎的经验[J].江苏中医,1999,20(11):6
110.王渭川,何焕霞,王渭川临床经验集[M].陕西人民出版社,西安,1979,30-132
111.金凤丽.易修珍,多途径给药综合治疗盆腔炎120例分析[J].云南中医药杂志,1999, 20(5):10
112.丛春雨主编.近现代二十五位中医名家妇科经验[M]中国中医药出版社,北京.1998.6:491
113.周翠珍.蔡小荪治疗妇科痼疾验方拾萃[J].江苏中医,1996,17(1):9
114.江一平等主编.中医辨治经验集萃—当代太湖地区医林聚英[M].人民卫生出版社,北京.1996:391
115.张鲁予,陈瑞香妇康宁汤治疗慢性盆腔炎70例临床观察[J].医药产业资讯,2005,第2卷,32-24
116.王春梅,汤利红,汪雪睛,当归芍药胶囊为主治疗慢性盆腔炎临床观察[J].四川中 医2006,24(11),81-82
117.张兴成,梁树兰,江燕,母元茂,盆炎灵治疗慢性盆腔炎100例疗效观察[J].四川中医,2006,24(1)24
118.童平辉,盆炎汤治疗慢性盆腔炎74例总结[J]湖南中医杂志2006,22(2)28-29
119.吴难.少腹逐瘀汤治疗慢性盆腔炎21例[J].南京中医药大学学报1997,13(1):49
120.解淑芳,赵月珍.少腹逐瘀汤加减治疗慢性盆腔炎46例[J].天津中医2001, 18(2):23
121.陈朋秋.当归芍药散加味治疗慢性盆腔炎[J].吉林中医药2000,18(5):37
122.陈南阳.四逆散合五味消毒饮治疗慢性盆腔炎46例[J].中国民间疗法2000,16(6):48
123.杨光华.完带汤加味治疗慢性盆腔炎48例[J].四川中医2001,19(5):54
124.高建军.妇炎康复片治疗盆腔炎性包块及不孕60例[J].中医临床杂志,2003,17(3):226
125.张诗平,周世文,汤建林等,妇炎康复片的抗炎抗菌活血化癖止痛作用实验研究[J]儿科药学杂志,2002,8 (2):13
126.杨华,乌晋芳.妇乐冲剂为主治疗输卵管不通51例[J].陕西中医,2001, 22, (6):344
127.王秀丽,杨新丽.“妇炎合剂”治疗慢性盆腔炎的临床观察[J].四川中医,2006 24(11):94-95
128.周晓燕.补肾活血法在慢性盆腔炎治疗中的应用[J].医药产业资讯2006, 3(11):113-114
129.王佳楣,肖承宗,权宁子.补肾疏肝法治疗慢性盆腔炎40例分析[J].中医药学刊,2006,22(6):1128-1129
130.吴光华,姜琪,梁党英,金鸡化瘀颗粒治疗慢性盆腔炎98例临床观察[J].中医药学报,2006,34(5):31-33
131.张磊昌.中药保留灌肠配合局部热敷治疗慢性盆腔炎40例[J].陕西中医,2002,23(5) :415
132.赵秀清,白香菊.中药灌肠液直肠保留时间对慢性盆腔炎疗效的影响[J].河北中医,2002,24 (7) :550
133.苏佩清,周晓宏,曹丽君等.六神栓治疗慢性盆腔炎118例[J].四川中医,2002,20 (12):45-46.
134.谢珍.中药保留灌肠加外敷治疗慢性盆腔炎临床观察[J].现代中西医结合杂志,2002,(11)3:228
135.万筱婷,董渝.国药保留灌肠治疗慢性盆腔炎62例[J].江西中医药,2001,32(3): 34
136.朱兰英.中药保留灌肠治疗慢性盆腔炎80例[J].实用中医药杂志,2001,17(7):16
137.郑红.温化活血汤保留灌肠治疗慢性盆腔炎86例[J].浙江中医杂志2001,36(10):426
138.傅绪梅.鱼败合剂治疗盆腔炎临床观察[J].湖北中医杂志,2000,22(4):226
139.王肖凤.中医肛肠点滴治疗慢性盆腔炎100例[J].江苏中医,1997,4(5):283
140.黄兰英.黄桂灌肠剂治疗慢性盆腔炎100例[J].江苏中医,1996,17(9):17
141.罗凤萍,李翠萍,马文侠.盆炎栓与野菊花栓治疗慢性盆腔炎的对比观察[J].中国中医药信息杂志,2001,8(6):61
142.郭雪桃,张月莲.康复消炎栓治疗慢性盆腔炎158例[J].山西中医,2000, 16 (10):23-24
143.刘荣.金刚藤胶囊合康妇消炎栓治疗慢性盆腔炎80例临床观察[J].社区医学杂志,2006,4(9):13-14
144.张爱芳.慢性盆腔炎综合治疗方法[J].中国医学学报,1997, 12 (3):61
145.李秀珍.中药外敷治疗慢性盆腔炎120例[J].吉林中医药,2001, (5):32
146.秦婵娟,刘蕾.秦氏化瘀止痛膏治疗慢性盆腔炎[J].河南中医,1999,19(2):45
147.程可佳,肖长泉.妇康乐脐疗慢性盆腔炎168例疗效分析[J].实用中西医结合杂志,1997,10(9):833
148.邵玉荣,中药灌肠配合温敷下腹治疗慢性盆腔炎效果观察[J].交通医学2006,20(6):770
149.徐枫,卢丹丹.中药熏洗湿敷法治疗慢性盆腔炎64例[J].中国中医药信息杂志,2001,8(1):64
150.沈克艰,吴梅珍.伏天铺灸治疗慢性盆腔炎的临床研究[J].上海针灸杂志,2005,24 (5):19-20
151.蔡玉华,艾莉,王燕.中药复方盆炎粉治疗慢性盆腔炎80例[J].中国中医药信息杂志,1998,5(3):39
152.罗曼华,活血化癖药物导入治疗慢性盆腔炎219例[J].广东医学,2001, 22(10):975
153.孟向文,孟东红.互动式针法治疗慢性盆腔炎50例临床观察[J].针刺研究,1998(4):298-299
154.岑克强,温针灸治疗慢性盆腔炎165例临床观察[J].吉林中医药,1999(1):35
155.尚晓琪,药灸法治疗慢性盆腔炎[J].中国针灸,2001,21(5):274
156.洪建云,欧兰芳,李福等.以腹丛刺为主,配以足三里,三阴交治疗CPID[J].中国针灸,2004,24(9):593-595
157.李和,李景芬.火针辨证治疗慢性盆腔炎疗效观察[J].中国针灸,2002,22(5):295-296
158.刘伟,周志红.DFI型电脑仿生治疗仪治疗急慢性盆腔炎45例[J].沈阳医学院学报,2001,3(3):164-165
159.龙春尧,郭冀萍,程雁.针灸治疗慢性盆腔炎63例[J].上海针灸杂志,2002,2 1(2):291
160.李辉,冯树军,朱琳.针刺配合熨灸法治疗慢性盆腔炎31例[J].四川中医,2003, 21(12):85
161.陈琼珍,针刺配合隔姜灸治疗慢性盆腔炎36例[J].福建医药杂志,2000, 22: (6):168-168
162.顾群.穴位注射治疗慢性盆腔炎的临床观察[J].针灸临床杂志,2004 ,20 (1) :40-41
163.李光荣.穴位注射治疗慢性盆腔炎54例[J].中国针灸杂志,2006,26(10):724
164.王倩,熊家轩.穴位注射结合超激光照射治疗慢性盆腔炎观察[J].中国针灸,2006,26 (9):615
165.周均,吴杰凤.药物注射治疗慢性盆腔炎腰腹痛的经验[J].成都中医药大学学报,2002,25(2):54
166.袁艺.针刺治疗慢性盆腔炎35例临床观察[J].贵州医药,2003,27(1):88-89
167.宋青霞,张俭欣,沙碧源.穴位药物埋线治疗慢性盆腔炎80例观察[J].中华实用中西医杂志,2003,3(16):95
168.王竹珍,谢柏如,胡卫东等.水针刀药磁线四联治疗慢性盆腔炎临床研究[J].中国基层医药,2003,10(8):776-777
169.赵芳.鱼腥草注射液穴注治疗慢性盆腔炎500例[J].中国民间疗法,2003 ,11(10):16.
170.曾晓智,文伙新,叶国杏等.穴位注射综合疗法治疗慢性盆腔炎42例疗效观察[J]. 新中医,2002 ,34 (8) :40
171,吴正林,王志林.按摩治疗慢性盆腔炎43例[J].河南中医药学刊,1997,12(6):22
172.王雁君,推拿治疗慢性盆腔炎30例[J].内蒙古中医药,1997(1):33
173.沈红云,张文兵.传统推拿治疗慢性盆腔炎52例[J].中国中医药信息杂志,2002,9 (4):78
174.余和平,夏新蜀,党元秀.等幅正弦中频电碘离子导入并超短波治疗慢性盆腔炎[J].中国物理医学与康复杂志,2002 ,24 (7) :390.
175.秦新常.低强度He Ne激光治疗慢性盆腔炎[J].中国激光医学杂志,2002,11(4):258.
176.胡静平,孟祥辉,刘英军.中药离子透入疗法治疗慢性盆腔炎50例[J].吉林中医药,2003,23(5):24
177.鲁凤.中药外治加特定电磁波照射治疗慢性盆腔炎968例.Proceeding of ClinicalMedicine J .2002,111(10):774
178.田洪珍,李全德.超短波及直流感应电疗仪对130例慢性盆腔炎治疗的观察[J].青海医药杂志,2002 ,32 (8) :47248
179.窦松柏.中药离子导入加穴位注射治疗慢性盆腔炎50例[J].陕西中医,1997,18(6):268-269
180.王惠英,杜建华.中药离于导入法治疗慢性盆腔炎92例[J].中医外治杂志,1996 (5):16-17
181.周莹,周丽.针刺为主治疗慢性盆腔炎55例[J].四川中医,2002,20(2):76.
182.金兰,蔡磊,牟华红.药饼灸脐联合康妇消炎栓治疗慢性盆腔炎62例[J].实用中西医结合临床,2004,4(5):51.
183.雷英,周巧玲,马刚,等.药物配合音频电及超短波透热综合治疗慢性盆腔炎[J].中国民族民间医药杂志,2003,(64):27 1-274.
184.王新玲,中西医结合治疗慢性盆腔炎包块61例[J].中医研究,2000,13 (4):56
185.陈雪珍,中西医结合治疗慢性盆腔炎80例临床观察[J].内蒙古中医药,1999,18(2):24-25
186.赵瑰丽,郭麦峰,中西药结合治疗慢性盆腔炎50例[J].陕西中医2006, 27(10):1176-1177
187.陈慧娟,边文会,李艳青等,中西医结合治疗慢性盆腔炎90例临床观察[J].河北中 医,2006 ,28(12):924-925
188.王艳芳,中西医结合治疗慢性盆腔炎152例[J].中医药导报,2007,13(1):54
189.马媛,袁新荣,刘辉,中西医结合治疗慢性盆腔炎临床观察[J].现代中西医结合杂志,2007,16(5):607-608
190.上海非手术绝育科研协作组.输卵管注药绝育的药理实验[J].中华妇产科杂志1979;14(2):98
191.陈镆鎁,等.笨酚胶浆剂注入人输卵管绝育的病理过程及其成败原因探讨[J].中华妇产科杂志1979; 14(2):84
192.陈学忠,等.活血化瘀方防治子宫内膜粘连的实验研究[J].中西医结合杂志1986;6(12):740
193.李玲,等.通管汤对家兔输卵管炎的抗炎作用[J].中西医结合杂志1987;7(5):293
194.连方,等.痛经宝与复方当归液治疗输卵管阻塞临床与实验研究[J].中西医结合杂志,1991;11(5):282
195.高慧.浅谈盆腔炎及输卵管炎性阻塞动物模型的演变[J].承德医学院学报1999 ;(4):16
196.马宝璋等.炎克宁冲剂对大鼠细菌性盆腔炎的影响[J]第七届全国中医妇科学术交流会论文集第5-8页1997
197.张三元.黑龙江中医药大学博士学位论文[D]盆腔炎发病机理的探讨2001
198.朱新群,贾殿举.马楠主编《妇科感染的基础与临床》[M]北京:科学出版社2002年
199.陈慰峰主编.《医学免疫学》[M]北京:人民卫生出版社2002
200.Mosmann TR,Cherwinsi H,Bond MW et al.Two types of murine helper T cell clones.I.Definition according to profiles of lymphokine activities and secreted proteins [J].Immunol,1986;136:2348
201.Romagnani S.The th1/Th2 paradigm[J].Immune Today,1997;18(6):263
202.形同京,章廉主编《Th细胞群极化群体的基础与临床》[M]军事医学科技出版社2002
203.Moore KW,de Waal Malefyt R,Coffman RL,et al.Interleukin-10 and the interleukin-10 receptor[J].Annu Rev Immunol,2001,19:683-765
204.Gerosa F,Nisii C,Righetti S,et al,CD4(+)T Cell clones producing both interferon -gamma and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary tuberculosis patients[J]Clin Immunol,1999,92(3):224-234
205.Mahanty S,Ravichandran M,Raman U,et al.Regulation of parasite antigen-driven immune responses by interleukin-10 and IL-2 in lymphatic filariasis[J].Infect Immun,1997,65(5):1742-1747
206.Whalen JD,Lechman EL,Carlos CA,et al,Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws[J],J Lmmunol,1999,162(6):3625-3632.
207.张占英,张澜生,殷秋华胸膜渗液中IFN-γ、 IL-2及NKCF活性的研究[J].上海医学免疫学杂志1995,15(3):153-156
208.Ito M,Kojiro N,Shirasaka T,et al,Elevated levels of Soluble Interleukin-2 Receptors in Tuberculous Pleural Effusions[J].Chest, 1990,97(5):1141-1143
209.邹阳,王兴友,杨孝芳.溃疡性结肠炎大鼠IL-2、 CD44、 CD54的实验研究[J].江西医学检验2002,20(5):281
210.Bucht A,Larsson P,Weisbrot L,et al.Expression of interferen garmma (1 FN-gamma), IL-10, IL-12 and transforming growth factor-beta(TGF-beta)Mrna in synovial fluidcells from patients in the early and late phases of rheumatoid arthritis[J].Clin Exp Immunol,1996,103(3):
211.Sharma K,Jin Y,Guo J,et al.Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice[J].Diabetes,1996,45(4):522
212.Szekanecz Z,Haines GK,Harlow LA,et al.Increased synovial expression of transforming growth factor (TGF)-βreceptor endoglin and (TGF)-β in rheumatoid arthritis :possible interactions in the pathogenesis of the disease[J].Clin Immunol Immunopathol,1995,7(2):187
213.Bowes MP.Zivin JA,R,Monoclonal antibody to the ICAM-ladhesion site reduces neurological damage in a rabbit cerebral embolismstroke model [J].Exp Neurol,1993,119(2):215-219
214.Vainer B.Role of cell adhesion molecules in inflammatory bowel diseases.Scand [J]Gastroenterol,1997,32:401-410
215.Szekanecz Z.Haines GK,Lin TR,et al.Differential distribution of intercellular adhesion molecules (ICAM-1,ICAM-2 and ICAM-3) and the MS-1 antigen in normal and diseased human synovia.Their possible pathogenetic and clinical significance in rheumatoid arthritis[J].Arthritis Rheum, 1994,37(2):221
216.Tak pp.Thurkow EW,Daha MR,et al.Expression of adhesion molecules in early rheumatoid synovial synovial tissue [J].Clin Immunol Immoupathol,1995,77(3):236
217.Koch AE,Shah MR,Harlow LA et al.Soluble intercellular adhesion molecule-1 in arthritis[J].Clin Immunol Immoupathol,1994,71(2):208
218.Kerr JF,Wyllie AH,Currie AR.Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetice.Br J Cancer, 1972;26(4):239
219.张延龄细胞凋亡与外科[J]国外医学外科分册1998,25(1),3
220.彭黎明 细胞凋亡的基础与临床[M]北京:人民卫生出版社2000年7月 第一版
221.李元敏译 借助治疗手段诱发细胞凋亡来缓解慢性炎症[J].国外医学药学分册1997;12(24),334
222.李春海 马知远 刘宏等 肿瘤分子生物学研究进展[J].军事医学科学出版社1996, 13-25
223.Thompson CB.Apoptosis in the pathogenesis and treatment of disease [J].Int Rev Cytol, 1999,267:1456-1458
224.Whyllie AH,Kanbson MD.Cell death the wytnificance of apoptosis[J].Int Rev Cytol, 2000,68:251-306
225.Catchpoole CR,Oeh PE,Zhang GH.Formation kf apoptosis bodies is associated with internucleosomal DNA fragmentation during drug-induced apoptposis[J].Exp Cell Res,2001,216:169- 177
226.Evan GI,Buhie R,pall Cg,et al.Induction of apoptnsis in fibroblasts by c-myc protein cell [J].2001.69:119-128
227.Shi Y,Mclos H.Role for c-myc in activation induced apoptosis:genetic controls on cell hybridomas, Int Rev Cytol,2000,257:212-214
228.Lane DP.P53,guardian of the genome.[J]Nature,2000,358:15-16
229.Kastan MB,Witale PJ,Gares BA,et al.P53,cell cycle control and apoptosis;implications for cancer,Cancer Metas Rev,2000,14:3-15
230.Zhu YM,Payham S,Baxlor G,et al.Wild-type p53 is required for apoptosis;induced by growth factor deprivation in factor dependent leukemic cell.Br J Cancer 1999, 69:468-472
231.Lane DP.A death in the life of p53 [J].Int Rev Cytol,2000,362:786-787 232.Los M,Hacia JG,Cheung JG;et al.Requirement of an ICE/CED-3 protease for FAS/APO-1 mediated apoptosis[J].Iet Rev Cytol,2000,375:81-87
233.Krajewska M,Wang HG,Krajewski S, et al,Immunohistochemical analysis of in vivo patterns of expression of CPP32(Caspase-3),a cell death protease [J].Cancer Res,1997;57:1605-1613
234.Samali A,Zhirotorsky B,Jones DP,et al.Detection of pro-caspase-3 in cytosol and mitochondria of various tissues [J].FEBS Lett, 1998;431(2):167-169
235.易念华等.武汉市部分城区妇女生殖道感染现状及危险因素研究[J].中国初级卫生保健,2004,18(3);47-51
236.魏映琴.白银市平川区农村妇女病普查状况分析[J].临床和实验医学杂志,2007,6(1):171
237.谢立春,钟于玲.深圳市流动已婚育龄妇女生殖健康现况调查[J].中国计划生育学杂志,2006,129(9):417-420
238.Yeh.JM,Hook EW 3~(rd), Goldie SJ.A refined estimate of the average lifetime cost of pelvic inflammatory disease[J].SeX Transm Dis.2003,30(3):369-378
239.Catherine L, Haggerty, Richard Schulz,etal.Ness, Lower Quality of Life Among Women With Chronic Pelvic Pain After Pelvic Inflammatory Disease[J].Obstetrics & Gynecology,2003,102(5):934
240.Mcggregor JA, Frence JI.Chlamydia trachomatis infection during pregnancy[J].Am J Obstet Gynecol, 2000,164:1792
241.李建霞.温州市龙湾区已婚育龄妇女生殖道疾病现状分析[J].中国医院统计,2004, 11,(2):151-152
242.Safrin S,etal.Longterm Sequence of Acute Pelvic Inflammatory Disease.A retrospective Cohort Study[J].Obstet Gynecol, 2001,166(4):1203
243.李长翠等.6513名已婚育龄妇女生殖道感染调查分析[J].社区医学杂志2004,2(1):53-54
244.Ross J.Pelvic Inflammatory Disease.BMJ, 2001,322:658-659
245.董悦,魏丽惠主编.妇产科学[M].北京大学医学出版社,2003,1:276-287
246.Simms I Stepheson JM.Pelvic inflammatory disease epidemiology:what do we know and what do we need to know?Sex Transm Inf 2002, 76: 80-87
247.乐杰,谢幸,丰有吉.妇产科学(第6版)[M].北京:人民卫生出版社,2004,1:268-276
248.白清芬,明秀丽.甲硝唑配伍糜蛋白酶侧穹窿封闭治疗慢性盆腔炎疗效观察[J].实用医技杂志,2003,10(3):204-205
249.张晓丽等.宫腔药物注射治疗慢性盆腔炎200例疗效分析[J].陕西医学杂志,2002, 54(10):1103-1104
250.强兆容.青霉素混合液阴道穹窿注药配盐热敷治疗慢性盆腔炎[J].中国妇幼保健,2006,21(5):229 1-2292
251.叶君儿.腹腔置管灌注抗生素结合中药灌肠治疗盆腔炎性包块的疗效观察与护理[J].浙江中医药大学学报,2006,30(6):688-689
252.郝存爱,张晔,王瑞新.射频加温治疗慢性盆腔炎135例分析[J].中医外治杂志,2003, 12(4):12
253.梁·陶弘景集.《名医别录》[M].北京:人民卫生出版社1986
254.明·李时珍著.《本草纲目》[M].北京:人民卫生出版社1956
255.清·张璐著.《本经逢原》[M].上海:上海科学技术出版社1959
256.清·吴鞠通著.《温病条辨》[M].上海:上海科学技术出版社1966
257.宋·陈自明原著,明·薛己校注.《校注妇人良方》[M].上海:上海卫生出版社1956
258.清·吴谦等编著.《医宗金鉴·外科心法要诀》[M].北京:人民卫生出版社1956
259.清·陈士铎著.《辨证录》[M].北京:人民卫生出版社1956
260.郭艳文,等.黄褐毛忍冬花与金银花的比较研究[J]药物分析杂志1990;10(1):2
261.刘寿山等.《中药研究文献摘要》[M].北京:科学出版社,1963:387
262.中国科学院上海药物研究所资料.1992
263.张家铨.黄芩、金银花的药理与临床应用[J].新医学1975;6(3):155-157
264.李希贤,等.金银花等药制菌作用的初步观察[J].中华医学杂志1955;41(10):952
265.刘国声.中药抗生力研究(第一报)[J]中华新医学报1950; 1 (2):95-97
266.重医附院内科中医中药研究组,等.[J]科学技术论文集(重医).1959;(3):37
267.江西省中医药研究所.[J]江西中医药1960;(1):34
268.林启寿.中草药成分化学[J].科学出版社,1977:93、 146
269.上海中药制药一厂.关于金银花研究总结1972
270.中医研究院中药研究所病毒组[J].新医药学杂志1973;(1):26
271.徐锦奋,等.中医药资料汇编(吉林医大)1973;(1):195
272.竺稽能,等.中西医结合汇编.急腹病第二集(湖北中医学院附院)1979:64
273.CA.[J]1961;55:20218
274.CA.[J]1971;74:97900g
275.李希贤.中国药学会1962年学术会议论文摘要集.1962:342
276.杭州市第二人民医院.杭州医药资料汇编.1977:62
277.南朝梁·陶弘景撰.《本草经集注》[M]上海:上海群联出版社1955
278.清·黄宫绣著.《本草求真》[M]上海:上海科学技术出版社1959
279.唐·甄权撰.《药性论》[M]芜湖 皖南医学院1983
280.吴越·日华子集.《日华子本草》[M]合肥:安徽科学技术出版社2005
281.明·兰茂著.《滇南本草》[M]昆明:云南科学技术出版社2004
282.明·缪希雍著.《神农本草经疏》[M]清光绪辛卯年(1891年)池阳周氏校刊本
283.刘超,王静,杨军.赤芍总甙活血化淤作用的研究[J].中药材,2000, 23 (9) :557-601
284.武新华,马秀敏.新疆赤芍抑菌实验研究[J].中国民族医药杂志,2005,(10)5 :30-31
285.雷玲,胡竟一,余悦等.赤芍的抗内毒素作用研究[J].中药药理与临床,2006, 22 (6):32-34
286.ChoiBM, Kim HJ, Oh GS.1, 2, 3,4,6-Penta-O-galloyl-beta -D-glucose protects rat neuronal cells (Neuro 2A) from hydrogen per2oxide-mediated cell death via the induction of heme oxygenase-1 [J].Neuroscience Letters, 2002, 328:185-189
287.Lee SJ, Lee IS, MarW.Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6 -penta-O-galloyl-beta-D-glucose in murine macrophage cells[J].Arch Pharm Res,2003,26:832-839
288.许惠玉,汪广荫,陈志伟.赤芍总甙对Bc122、c-myc基因表达影响及诱导细胞凋亡机制研究[J].中国免疫学杂志,2005, 21(6):778-780
289.何延龙,周端,董六一.赤芍总苷对大鼠局灶性脑缺血再灌注损伤的保护效果[J]. 中国临床康复,10(39)3:56-61
290.孙大军,祁功才,吕文伟.赤芍总苷对实验性血栓形成的影响及其作用机制[J].中国老年学杂志,2006,26(12) :1080-1081
291.汉·张仲景著《伤寒论》[M]北京:人民卫生出版社影印1956
292.宋·陈师文等编著《太平惠民和剂局方》[M]北京:人民卫生出版社1959
293.张秀娟,李津明,霍明.黄芩水煎液黄芩甙去黄芩甙水煎液抑菌试验比较[J].黑龙江商学院学报(自然科学版) ,1997 ,13 (4):6-9
294.缪红,程建军,苏丙凡等.黄芩茎叶总黄酮对角叉菜胶诱发小鼠尾部血栓形成的抑制作用[J].时珍国医国药,2006, (17)12 :2420-2421
295.程国强,冯年平,唐琦文等.黄芩甙对眼科常见病原菌的体外抗菌作用[J].中国医院药学杂志,2001 ,21 (6) :384 -385
296.罗晶,顾红缨.黄芩甙体外抗解脲支原体作用[J].微生物学杂志.2006,26(5):96-97
297.麦水强,闫玉欣,丁刚等.黄芩甙治疗细菌性脑膜炎的临床研究[J].中国妇幼保健,2006,21(6):2948-2950
298.张喜平,周田美,董晓勤.黄芩苷注射液体外抗菌作用实验研究[J].医学研究杂志,2006,(35)8:39-41
299.贺海平,秦箐,陈明.黄芩类黄酮对人免疫细胞化学发光及淋巴细胞增殖的影响[J].中国免疫学杂志,2000,16(2):84-86
300.卢艳,孔令彩,栾云等.黄芩苷对离体心脏缺血再灌注损伤的保护效应[J].中国临床康复.2006,(35)10 :48-50
301.钟秀会,周占祥,孙秉贵等.黄芩白术对LPS诱导流产小鼠的保胎作用及子宫内TNF-α含量的影响[J].畜牧兽医学报,2000 ,31 (5):430-435
302.清·顾观光重辑.《神农本草经》[M]北京:人民卫生出版社影印1956
303.清·程国彭著.《医学心悟》[M]北京:人民卫生出版社影印本1955
304.清·汪昂著.《医方集解》[M]上海:上海科学技术出版社1959
305.冯明[J]兰州医学院论文集1964;(12):23
306.袁铣帆,等[J]中国中药杂志1991;16(3):150
307.金·张元素撰.《医学启源》[M]北京:人民卫生出版社1978
308.金·李杲撰.《脾胃论》[M]北京:人民卫生出版社影印本1957
309.刘萍,杨芳寅.中药柴胡抗细菌内毒素的实验研究[J].中成药,2002,24(8):62
310.何美姗,孙小玉.正柴胡饮颗粒的解热及抗过敏作用[J].中草药,2000,31(4):284-285
311.于庆海.柴胡皂甙的抗炎作用初探[J].沈阳药学院学报1996,3(1):14-16
312.佟丽,陈江华.小柴胡片药效实验研究[J].时针国医国药,1998:9(6):519-520
313.张丽娟.柴胡皂甙-d的免疫调节作用[J].国外医学·中医中药分册,1995,17(2):40-41
314.吴丽花,耿宝琴.小柴胡胶囊及保肝作用研究[J].中药药理与临床,1999,15(6):3-5
315.Sen R,Baltimore D.Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism [J].Cell 1986 Dec26,47(6):921-928.
316.Grigoryev DN, Finigan JH, Hassoun P, Garcia JG.Science review: searching for gene candidates in acute lung injury[J].Crit Care,2004, 8(6): 440-447
317.Abraham E.NF-KappaB activation[J].Crit Care Med, 2000,28: 100-104
318.Puneet P, Moochhala S, Bhatia M.Chemokines in actue respiratory distress syndrome.Am [J]Physiol Lung Cell Mol Physiol,2005,288(1):3-15
319.Qu J, Zhang J, Pan J, He L, Ou Z, Zhang X, Chen X.Endotoxia tolerance inhibits lipopolysaccharide-initiated acute pulmonary inflammation and lung injury in rats by the mechanism of nuclear factor-kappaB[J].Immunol, 2003,58:613-619
320.Buccelletti F, Mazzone M, Portale G, Forte P, Bononi F, Mirabella C, Travaglino F, Gentilonl SN.Humoral and cellular inflammatory mediators in acute lung injury:friends or enemies?Minerva Med, 2003,94: 57-65
321.Paul PT, Gary SF.NF-kappaB:a key role in inflammatory diseases[J].Chin Invest.2001,107:7-11
322.李海燕.沙眼衣原体感染引起输卵管性不孕的机理[J].国外医学计划生育分册.2000 19(4):226-228
323.张强华.类风湿性关节炎的发病机制[J].国外医学·免疫学分册.1994,17(1):40
324.Malik AB,Lo SK.Vascular endothelial adhesion molecules and tissue in lammation[J].Pharmacology Rev, 1996,48 (2):213-221
325.[1]Bazzoni F, Beutler B.The tumor necrosis factor ligand and receptor families[J].New Engl J Med, 1996;334(26):1717—1725
326.Chang JH, Ryang YS, Morio T,etal.Trichomonas vaginalis inhibits proinflamm-atory cytokine production in macrophages by suppressing NF-κB activative[J].Mol Cells 2004,18(2):177-185
327.Kettritz R, Choi M, Rolle S, etal.Integrins and cytokines activate nuclear transcription factor kappaB in human neutrophils[J].Biol Chem, 2004, 279 (4):2657-2665
328.Lim S, Kang KW, Park SY, etal.Inhibition of lipopolysaccharide induced inducible nitric oxide synthase expression by a novel compound, mercaptopyrazine,through suppression of nuclear factor-kappaB to DNA[J].Biochem Pharmacol 2004, 68(4):719-728
329.Zimmerman MA, Reznikov LL, Raeburn CD,, etal.Interleukin-10 attenuates the response to vascular injury.J.Sung.Res.2004,121:206-213
330.ACOG practice bulletin number 51.Chronic pelvic inflammatory[J].Obstetrics & Gynecology, 2004, 103(3):589-605
331 .Ariga K, Miyamoto S, Nakase T, et al.The relatioship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc[J].Spine,2001,26(22):2414-2420
332.Sharif M, Whitehouse A, Sharman P, et al.Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase 3[J].Arthritis Rheum, 2004,50(2):507-515
333.Rannou F, Lee TS, Zhou RH, et al.Intervertebral disc degenerationahe role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload[J].Am J Pathol,2004,164(3):915-924
334.罗涵 超氧化岐化酶的临床意义[J].国外医学生理病理学分册2000.5(2):148
335.Svensson LG, et al.Br J Surg,1987;74(4):282
336.钱素英,夏兆雄,徐建芬等.恶性肿瘤患者血一氧化氮、内皮素及超氧化物歧化酶的变化[J].肿瘤学杂志,2001,7(5):270-271
337.Haapasalo H, Kylaniemi M, Paunul N, et al.Expression of antioxidant enzymes in astrocytic brain tumors[J].Brain Pathol, 2003,13(2):155-164
338.Ivanova E, Angelova M, Slokoska L.Effect of Cu/ Zn-superoxide dismutase from the fungal strain Humicola lutea 103 on antioxidant defense of Graffitu morn-bearing hamsters[J].Z Naturforsch. 2002,57(1-2):197-204
339.Tiku ML, Loesch JB, Robertson FM. Production of Hydrogen peroxide by Rabits articular chondrocytes enhancement by cytokines[J]. The Journal of Immunology,2000, 145(2):690-696