全光纤口腔OCT方法研究与系统研制
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摘要
基于光学相干层析(OCT)技术,研制了口腔龋齿检测系统。主要研究了利用OCT方法检测由于牙齿内部脱矿导致的牙齿光学特性参数的变化规律,并以此来对龋齿、特别是早期龋齿进行诊断和控制。此方法对于龋齿的早期诊断、治疗和预防具有重要的作用。
本论文主要从理论研究、仪器化设计、系统实验和应用研究等几个方面对口腔OCT检测系统进行了深入的研究:分析了全光纤OCT系统的基本原理;对牙齿组织的光学传输特性进行了模拟;设计并研制了全光纤偏振不敏感OCT系统,获得了人离体牙齿的一维、二维、三维OCT图像。设计并建立了全光纤偏振OCT实验系统,初步获得了人离体牙齿的偏振OCT图像;基于OCT系统平台,开展了龋齿早期诊断方法的研究,并进行了应用性实验研究,开展了人离体牙齿折射率测量、人工龋体外建模、龋齿及牙齿修复体OCT成像等实验。
工作中的主要创新点:
1.研制了全光纤偏振不敏感OCT系统。获得了人的正常离体牙齿、龋损离体牙齿以及常用口腔修复体的一维、二维OCT图像。利用基于规则体数据的三维表面模型构建算法进行了三维建模,并且获得了人离体牙齿的表面三维OCT图像。
2.将OCT技术应用于早期龋齿检测,初步探究了利用OCT方法检测龋齿及早期龋齿的方法,采用OCT对人离体牙齿开展了人工龋体外建模的实验性研究。结合OCT的方法测量了人离体牙釉质、牙本质和牙骨质的折射率,并且得到了离体牙齿沿扫描方向的折射率分布。
3.对牙齿的双折射特性进行了分析和建模,分析了全光纤系统中光纤的影响,设计并建立了全光纤偏振OCT系统,初步获得了人离体牙齿的偏振OCT图像。
4.以层状组织模型对生物组织的光学传输特性进行了建模,分析了牙釉质和牙本质的结构特征,并根据它们的光学参数对牙釉质和牙本质表面及内部光分布进行了模拟计算。
Based on Optical Coherence Tomography (OCT), this dissertation has developed the oral caries OCT detection system. The major study of this dissertation is using the OCT method to detect the caries by detecting the changes of the optical parameters caused by early demineralization. This method plays an important role for diagnosis the dental caries, particularly for the early diagnosis, control, treatment and preventiaon.
This dissertation focuses on the basic theory of OCT, the system design, system experiments and application experiments, the major studies of the dissertation are: the analysis of the all-fiber OCT system’s basic principle; the simulation of optical transmission characteristics of the teeth; design and development of all-fiber polarization insensitive OCT system; access to the one-dimensional, 2D and 3D OCT images of human teeth in vitro; design and development of the all-fiber polarization sensitive OCT system, polarization OCT images of the human teeth in vitro are initially obtained; the use of the OCT system for application experiments inclued of the measurement of the refractive index of human teeth in vitro and modeling of external experiments, in addition, the experiments obtaining the OCT images of dental caries and the restoration of teeth.
The major innovation in the work:
1. Design and development of the all-fiber polarization insensitive OCT system have been developed. The one-dimensional and two-dimensional OCT images of the normal and caries teeth are obtained. The one-dimensional and two-dimensional OCT images of the common oral restoration are also obtained. The rule shape data-based three-dimensional surface model algorithm has been developed and models for the teeth. The three-dimensional reconstructions of OCT images of the human teeth in vitro are obtained.
2. This dissertation applies the OCT technology to detect early dental caries and studies the method of detecting the early dental caries using OCT. The experimenal research of the external model that simulates the caries articially for the human teeth in vitro is illustrated. Based on OCT method, the refractive indexes of the human enamel, dentin and cementum are measured. In addition, the refractive index distribution along the scan direction of the human teeth in vitro is obtained.
3. Birefringence of the teeth and fiber are analysed and modeled. The all-fiber polarization sensitive OCT system has been developed; the polarization OCT images of the human teeth in vitro are initially obtained.
4. The layered model to character the optical transmission portery of the organization is illustrated. The structural characteristics of enamel and dentin are described and in accordance with their optical parameters, the distribution of light on and below the enamel and dentin surface are simulated.
本论文主要从理论研究、仪器化设计、系统实验和应用研究等几个方面对口腔OCT检测系统进行了深入的研究:分析了全光纤OCT系统的基本原理;对牙齿组织的光学传输特性进行了模拟;设计并研制了全光纤偏振不敏感OCT系统,获得了人离体牙齿的一维、二维、三维OCT图像。设计并建立了全光纤偏振OCT实验系统,初步获得了人离体牙齿的偏振OCT图像;基于OCT系统平台,开展了龋齿早期诊断方法的研究,并进行了应用性实验研究,开展了人离体牙齿折射率测量、人工龋体外建模、龋齿及牙齿修复体OCT成像等实验。
工作中的主要创新点:
1.研制了全光纤偏振不敏感OCT系统。获得了人的正常离体牙齿、龋损离体牙齿以及常用口腔修复体的一维、二维OCT图像。利用基于规则体数据的三维表面模型构建算法进行了三维建模,并且获得了人离体牙齿的表面三维OCT图像。
2.将OCT技术应用于早期龋齿检测,初步探究了利用OCT方法检测龋齿及早期龋齿的方法,采用OCT对人离体牙齿开展了人工龋体外建模的实验性研究。结合OCT的方法测量了人离体牙釉质、牙本质和牙骨质的折射率,并且得到了离体牙齿沿扫描方向的折射率分布。
3.对牙齿的双折射特性进行了分析和建模,分析了全光纤系统中光纤的影响,设计并建立了全光纤偏振OCT系统,初步获得了人离体牙齿的偏振OCT图像。
4.以层状组织模型对生物组织的光学传输特性进行了建模,分析了牙釉质和牙本质的结构特征,并根据它们的光学参数对牙釉质和牙本质表面及内部光分布进行了模拟计算。
Based on Optical Coherence Tomography (OCT), this dissertation has developed the oral caries OCT detection system. The major study of this dissertation is using the OCT method to detect the caries by detecting the changes of the optical parameters caused by early demineralization. This method plays an important role for diagnosis the dental caries, particularly for the early diagnosis, control, treatment and preventiaon.
This dissertation focuses on the basic theory of OCT, the system design, system experiments and application experiments, the major studies of the dissertation are: the analysis of the all-fiber OCT system’s basic principle; the simulation of optical transmission characteristics of the teeth; design and development of all-fiber polarization insensitive OCT system; access to the one-dimensional, 2D and 3D OCT images of human teeth in vitro; design and development of the all-fiber polarization sensitive OCT system, polarization OCT images of the human teeth in vitro are initially obtained; the use of the OCT system for application experiments inclued of the measurement of the refractive index of human teeth in vitro and modeling of external experiments, in addition, the experiments obtaining the OCT images of dental caries and the restoration of teeth.
The major innovation in the work:
1. Design and development of the all-fiber polarization insensitive OCT system have been developed. The one-dimensional and two-dimensional OCT images of the normal and caries teeth are obtained. The one-dimensional and two-dimensional OCT images of the common oral restoration are also obtained. The rule shape data-based three-dimensional surface model algorithm has been developed and models for the teeth. The three-dimensional reconstructions of OCT images of the human teeth in vitro are obtained.
2. This dissertation applies the OCT technology to detect early dental caries and studies the method of detecting the early dental caries using OCT. The experimenal research of the external model that simulates the caries articially for the human teeth in vitro is illustrated. Based on OCT method, the refractive indexes of the human enamel, dentin and cementum are measured. In addition, the refractive index distribution along the scan direction of the human teeth in vitro is obtained.
3. Birefringence of the teeth and fiber are analysed and modeled. The all-fiber polarization sensitive OCT system has been developed; the polarization OCT images of the human teeth in vitro are initially obtained.
4. The layered model to character the optical transmission portery of the organization is illustrated. The structural characteristics of enamel and dentin are described and in accordance with their optical parameters, the distribution of light on and below the enamel and dentin surface are simulated.
引文
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