艾灸对肿瘤化疗后外周血淋巴细胞凋亡影响的研究
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摘要
本文通过临床观察，进一步探讨艾灸对抗肿瘤化疗副反应的确
切疗效和可能的作用机理。根据中医基础理论，结合肿瘤患者化疗
后的临床表现，认为该病患者多属“虚劳”，故扶正培本为其基本治
则，并拟定相应的灸疗处方。临床治疗30例肿瘤化疗患者，疗效显
著，优于对照组。
研究表明，肿瘤患者化疗后细胞免疫功能低下及外周血淋巴细
胞凋亡加速是肿瘤化疗的严重副反应之一，以致患者无法顺利地完
成化疗。艾灸可通过扶正培本、补益先天之精、后天之气血来提高
患者免疫功能和抑制外周血淋巴细胞凋亡，从而达到拮抗肿瘤化疗
毒副作用，缓解各项临床症状，帮助患者顺利完成化疗的目的。与
对照组相比，艾灸疗法具有作用持久稳定、安全且价格低廉的特点，
为本病的治疗及机理探讨提供了新的思路。
The therapeutic effect of nioxribustion on Ma]igant Tumor after chemotherapy and
its operating mechanism was discussed systematically in this paper. Based on the theory
of Traditional Chinese Medicine and the clinical manifestations after chemotherapy, the
author proposed that the pathogenesis was onsumptive disease?.Therefore the them-
peutic principle of Invigorating the vital - qi was put forward and the corresponding
moxibustion prescription was also given. Clinical observation on 30 cases indicated that
the therapeutic effect of the nioxibusflon group was remarkably better than that of the
control group.
The study shows that the decrease of cellular immune ftmction and acceleration of
Apoptosis of peripheral Blood lymphocyte are two serious side effects in patients with
Malignant Tumor after chemotherapy which brought about failure to finish chemotherapy
smoothly. Moxibustion can improve cellular immune function and inhibit Apoptosis of
peripheral Blood lymphocyte to resist side effects of chemotherapy by means of support-
ing the vital qi,benefluing congenital essence and acquired qi and blood.
Compared with the simple Western medicine, moxibustion is much more safer and
it releases side effects efficiently in order to help patients spend their chemotherapy
smoothly. So a new train of thought was supplied for the teseareh of Maligant Tumor.
切疗效和可能的作用机理。根据中医基础理论，结合肿瘤患者化疗
后的临床表现，认为该病患者多属“虚劳”，故扶正培本为其基本治
则，并拟定相应的灸疗处方。临床治疗30例肿瘤化疗患者，疗效显
著，优于对照组。
研究表明，肿瘤患者化疗后细胞免疫功能低下及外周血淋巴细
胞凋亡加速是肿瘤化疗的严重副反应之一，以致患者无法顺利地完
成化疗。艾灸可通过扶正培本、补益先天之精、后天之气血来提高
患者免疫功能和抑制外周血淋巴细胞凋亡，从而达到拮抗肿瘤化疗
毒副作用，缓解各项临床症状，帮助患者顺利完成化疗的目的。与
对照组相比，艾灸疗法具有作用持久稳定、安全且价格低廉的特点，
为本病的治疗及机理探讨提供了新的思路。
The therapeutic effect of nioxribustion on Ma]igant Tumor after chemotherapy and
its operating mechanism was discussed systematically in this paper. Based on the theory
of Traditional Chinese Medicine and the clinical manifestations after chemotherapy, the
author proposed that the pathogenesis was onsumptive disease?.Therefore the them-
peutic principle of Invigorating the vital - qi was put forward and the corresponding
moxibustion prescription was also given. Clinical observation on 30 cases indicated that
the therapeutic effect of the nioxibusflon group was remarkably better than that of the
control group.
The study shows that the decrease of cellular immune ftmction and acceleration of
Apoptosis of peripheral Blood lymphocyte are two serious side effects in patients with
Malignant Tumor after chemotherapy which brought about failure to finish chemotherapy
smoothly. Moxibustion can improve cellular immune function and inhibit Apoptosis of
peripheral Blood lymphocyte to resist side effects of chemotherapy by means of support-
ing the vital qi,benefluing congenital essence and acquired qi and blood.
Compared with the simple Western medicine, moxibustion is much more safer and
it releases side effects efficiently in order to help patients spend their chemotherapy
smoothly. So a new train of thought was supplied for the teseareh of Maligant Tumor.
引文
1 汤钊猷主编．现代肿瘤学．上海：上海医科大学出版社．1993，第1版：1
2 孙靖中，邹雄主编．肿瘤分子生物学．北京：人民出版社．1998，第1版：173．
3 同[1]：337
4 徐燮渊，俞受程，曾逖闻主编．新编肿瘤诊疗手册．北京：金盾出版社．1999，第1版：662
5 同[1]：427
6 沈国伟，肖扬，高雍康．针灸足三里对抗化疗呕吐反应临床研究．中国针灸．2001；21(3)：158～160
7 黄晓，赵粹英．灸法抗癌与肿瘤热疗．针灸临床杂志．1996；12(10)：31～32
8 同[2]：180
9 Alexander Bloch. Cancer Treat. Rep.1984;(68):199～203
10 何任．鉴古观今说肿瘤．浙江中医学院学报．1999；23(1)：23～25
11 Memichael. T Cell Subset and Cellularimmunity. Academic Press.1984:24～26
12 同[1]：126～129
13 Kerr JFR, winterford CM, Bid ADA, et al. Apoptosis:Its significance in cancer and cancer Therapy. Cancer. 1994;13(8):2013
14 许志祥．细胞凋亡在肿瘤形成和治疗中的意义．国外医学·内科学分册．105；22(7)：289
15 Salem Chouaib, Carine Asselin-Paturel, Fathia Mami-Chouaib, et al. The host-tumor immune conflict: from immunmosuppression to resistance and destruction, Immumology Today. 1997;18(10):493～497
16 周振英，张军妮，朱月清，等．恶性肿瘤患者化疗后外周血淋巴细胞凋亡的变化．实用癌症杂志．1998；13(2)：118～119
17 刘海峰．Bcl-2基因与细胞凋亡．医学研究通讯．1998；27(6)：13～15
2 孙靖中，邹雄主编．肿瘤分子生物学．北京：人民出版社．1998，第1版：173．
3 同[1]：337
4 徐燮渊，俞受程，曾逖闻主编．新编肿瘤诊疗手册．北京：金盾出版社．1999，第1版：662
5 同[1]：427
6 沈国伟，肖扬，高雍康．针灸足三里对抗化疗呕吐反应临床研究．中国针灸．2001；21(3)：158～160
7 黄晓，赵粹英．灸法抗癌与肿瘤热疗．针灸临床杂志．1996；12(10)：31～32
8 同[2]：180
9 Alexander Bloch. Cancer Treat. Rep.1984;(68):199～203
10 何任．鉴古观今说肿瘤．浙江中医学院学报．1999；23(1)：23～25
11 Memichael. T Cell Subset and Cellularimmunity. Academic Press.1984:24～26
12 同[1]：126～129
13 Kerr JFR, winterford CM, Bid ADA, et al. Apoptosis:Its significance in cancer and cancer Therapy. Cancer. 1994;13(8):2013
14 许志祥．细胞凋亡在肿瘤形成和治疗中的意义．国外医学·内科学分册．105；22(7)：289
15 Salem Chouaib, Carine Asselin-Paturel, Fathia Mami-Chouaib, et al. The host-tumor immune conflict: from immunmosuppression to resistance and destruction, Immumology Today. 1997;18(10):493～497
16 周振英，张军妮，朱月清，等．恶性肿瘤患者化疗后外周血淋巴细胞凋亡的变化．实用癌症杂志．1998；13(2)：118～119
17 刘海峰．Bcl-2基因与细胞凋亡．医学研究通讯．1998；27(6)：13～15