液相色谱—串联质谱技术对食品中主要兽药残留的研究
|
摘要
随着人们对食品的质量和安全要求越来越高,近几年来我国发生的食品安全危害事件被频繁报道,一些不法食品生产者和经营者使用违禁药物、超量使用药物剂量、不遵守国家相关法律法规的案件也屡次发生,这为我国食品安全管理人员敲响了警钟,也为我们科研工作者提出了新的要求,如何能够高效、快速、灵敏的检测痕量兽药多残留成为亟待解决的课题。液相色谱串联质谱是食品安全分析的主要技术手段之一,对高沸点、不挥发和热不稳定化合物的分离和鉴定具有独特优势,同时具有多组分的的定性和定量能力,对食品等复杂基质样品中的痕量化合物的测定具有高选择性、高灵敏度的特点。本研究的主要目标是跟踪和瞄准国际上现代残留分析的先进技术,针对食品中主要兽药的残留情况,依据食品中国内外兽药最高残留限量(MRL)要求,通过对食品样品的提取、净化、检测和阳性确证等多方面的系统研究,采用液相色谱-串联质谱技术,建立一系列食品中主要兽药残留的检测方法,并在此研究基础上进行标准化,为我国食品安全状况得到根本改善等诸多方面起到积极重要的作用和奠定下坚实的基础,解决了食品安全检测中的一系列技术难题。本研究分为三个部分,第一部分主要是动物源食品中硝基咪唑类药物残留检测技术研究,第二部分主要是动物源食品中氟喹诺酮类兽药残留检测技术研究,第三部分主要是动物源食品中磺胺类药物残留检测技术研究。通过在对动物源食品样品的提取、净化、检测和阳性确证等多方面的系统研究,研究建立动物源食品中3种主要兽药残留量的系统检测方法,检测的药物品种范围能覆盖和基本满足国内外现行相关法规和标准的要求,检测方法的准确度、精密度满足残留分析质量控制指南的技术要求,检测低限达到国内外MRL的要求,与现行方法相比,整个检验周期缩短50%以上,降低检测成本60%以上,使我国的残留检测技术水平与国际同步。
While the requirements of quality and food safety are changing stricter, the harmful accidents of food safety are frequetly reported, the cases of some immoral producers and sellers of foods using forbidden drugs, overdoing drugs, not observing related legal laws often happen. All these ring alarms for food safety admistrators and propose new requirements for related researchers. How to effectively, quickly, and sensitively determine the trace contents of animal drugs becomes an urgent task. Liquid chromatography tadem mass spectropy (LC-MS/MS) is one of the main food safety analyitcal technologies, which show special advantages to seperation and identification of high boiling point, involatile and Thermo-instable compounds, and high seletivity and sensitivty to trance analysis. The main aim of this research is to follow and target on the morden international residue analysis technolgies. By systemic studying including extraction, cleaningup, determination and positive confirmation etc., using LC-MS/MS, a serial testing methods of determining animal drugs in foods and the followed standardization have been developed, as acts important effect, builds stable base, solve many technical questions for food safety and related areas in China. The research is divided into three parts. The first part is the studying of testing technolgy of nitroimidazoles in animal original foods, the second part is the studying of testing technolgy of fluoroquinolones in animal original foods, the third part is the studying of testing technolgy of sulfonamides in animal original foods. The tested compounds in the yielded methods to determine three animal drugs in animal original foods, cover and satisfy the current domestic and international requirements, the limits of detection conform to the current domestic and international MRL requirements. The testing periods compared to the current mothods are shorten 50%, and the costs are shorten 60%, as makes the residue analysis of China step the same pace as the internation level.
While the requirements of quality and food safety are changing stricter, the harmful accidents of food safety are frequetly reported, the cases of some immoral producers and sellers of foods using forbidden drugs, overdoing drugs, not observing related legal laws often happen. All these ring alarms for food safety admistrators and propose new requirements for related researchers. How to effectively, quickly, and sensitively determine the trace contents of animal drugs becomes an urgent task. Liquid chromatography tadem mass spectropy (LC-MS/MS) is one of the main food safety analyitcal technologies, which show special advantages to seperation and identification of high boiling point, involatile and Thermo-instable compounds, and high seletivity and sensitivty to trance analysis. The main aim of this research is to follow and target on the morden international residue analysis technolgies. By systemic studying including extraction, cleaningup, determination and positive confirmation etc., using LC-MS/MS, a serial testing methods of determining animal drugs in foods and the followed standardization have been developed, as acts important effect, builds stable base, solve many technical questions for food safety and related areas in China. The research is divided into three parts. The first part is the studying of testing technolgy of nitroimidazoles in animal original foods, the second part is the studying of testing technolgy of fluoroquinolones in animal original foods, the third part is the studying of testing technolgy of sulfonamides in animal original foods. The tested compounds in the yielded methods to determine three animal drugs in animal original foods, cover and satisfy the current domestic and international requirements, the limits of detection conform to the current domestic and international MRL requirements. The testing periods compared to the current mothods are shorten 50%, and the costs are shorten 60%, as makes the residue analysis of China step the same pace as the internation level.
引文
[1] Li H, Kijak PJ, Turnipseed SB, et al. Analysis of veterinary drug residues in shrimp: A multi-class method by liquid chromatography-quadrupole ion trap mass spectrometry[J]. Journal of Chromatography B-analytical Technologies in the Biomedical and Life Sciences, 2006, 836: 22-38.
[2] Reeves P. T. Residues of veterinary drugs at injection sites[J]. Journal of Veterinary Pharmacology and Therapeutics, 2007, 1: 1-17.
[3] Stolker A. A. M., Zuidema T., Nielen M. W. F., et al. Residue analysis of veterinary drugs and growth-promoting agents[J]. Trac-trends in Analytical Chemistry, 2007, 10: 967-979.
[4] Chonan Takao, Fujimoto Toru, Ueno Ken-ichi, et al. Multi-residue method for determination of veterinary drugs and feed additives in meats by HPLC[J]. Journal of the Food Hygienic Society of Japan, 2007, 5: 153-158.
[5] Fitzpatrick S C, Vilim A, Lambert G, et al. Dietary intake estimates as a means to the harmonization of maximum residue levels for veterinary drugs. II. Proposed application to the Free Trade Agreement between the United States and Canada[J]. Regulatory toxicology and pharmacology, 1996, 2: 177-183.
[6] Cerniglia CE, Kotarski S. Evaluation of veterinary drug residues in food for their potential to affect human intestinal microflora[J]. Regulatory Toxicology and Pharmacology, 1999, 3:238-261.
[7] Boxall ABA, Fogg LA, Blackwell PA, et al. Veterinary medicines in the environment[J]. Reviews of Environmental Contamination and Toxicology, 2004, 180:1-91.
[8] Weiss C.,Conte A., Milandri C., et al. Veterinary drugs residue monitoring in Italian poultry: Current strategies and possible developments[J]. Food Control, 2007,9: 1068-1076.
[9] Yamamoto Miyako, Toda Miou, Sugita Takiko, et al. Studies on the results of monitoring of veterinary drug residues in food products of animal origin inJapan and other countries[J]. Bulletin of National Institute of Health Sciences, 2009, 127: 84-92.
[10] Zeleny Reinhard, Ulberth Franz,Gowik Petra, et al. Developing new reference materials for effective veterinary drug-residue testing in food-producing animals[J]. Trac-trends in Analytical Chemistry, 2006, 9: 927-936.
[11] Paige JC; Tollefson L; Miller MA. Health implications of residues of veterinary drugs and chemicals in animal tissues[J].Veterinary Clinics of North America-food Animal Practice,1999,1:31-40
[12] Noguchi Shoichiro, Terada Hisaya, Tamura Yukio. Simultaneous determination of veterinary drugs in livestock foods and Seafoods using liquid chromatography/tandem mass spectrometry[J]. Journal of the Food Hygienic Society of Japan, 2008, 3: 177-188.
[13] Engeli Barbara. Regulation of veterinary drug residues in foodstuffs of animal origin, special case nitrofurans[J]. Mitteilungen aus Lebensmitteluntersuchung und Hygiene, 2003, 6: 527-533.
[14] Tittlemier S. A.,Van de Riet J., Burns G., et al. Analysis of veterinary drug residues in fish and shrimp composites collected during the Canadian Total Diet Study, 1993-2004[J]. Food Additives and Contaminants, 2007, 1: 14-20.
[15] Kennedy D. Glenn, Young Paul B., McCracken Robert J.. Analysis of veterinary drug residues in food: The nitrofuran issue[J]. Mitteilungen aus Leben smitte luntersuchung und Hygiene, 2003, 6: 510-526.
[16] Blasco Cristina, Pico Yolanda, Andreu Vicente. Analytical method for simultaneous determination of pesticide and veterinary drug residues in milk by CE-MS[J]. Electrophoresis, 2009, 10: 1698-1707.
[17] Talley MR. The National Milk Safety Program and drug residues in milk[J]. Veterinary Clinics of North America-food Animal Practice, 1999, 1: 63-+.
[18] Chonan T, Nishimura K, Hirama Y. Rapid determination of residues of five kinds of veterinary drugs in livestock products by HPLC[J]. Journal of the Food Hygienic Society of Japan, 2000, 5: 326-329.
[19] Kabir J, Umoh VJ, Audu-okoh E,et al. Veterinary drug use in poultry farmsand determination of antimicrobial drug residues in commercial eggs and slaughtered chicken in Kaduna State, Nigeria[J]. Food Control, 2004, 2: 99-105.
[20] Stolker AAM, Brinkman UAT. Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals - a review[J]. Journal of Chromatography A, 2005, 1-2: 15-53.
[21] Saito Mizue, Kozutsumi Daisuke, Kawasaki Michiko. Multiresidue method for pesticides and veterinary drugs in bovine milk using GC/MS and LC/MS/MS. Shokuhin eiseigaku zasshi[J]. Journal of the Food Hygienic Society of Japan, 2008, 3: 228-238.
[22] Yoshida Emiko, Shibuya Takahiro, ,Kurokawa Chieko. Quick simultaneous determination of residual veterinary drugs in processed food. Shokuhin eiseigaku zasshi[J]. Journal of the Food Hygienic Society of Japan, 2011, 1: 59-65.
[23] Peters R. J. B., Bolck Y. J. C., Rutgers P. Multi-residue screening of veterinary drugs in egg, fish and meat using high-resolution liquid chromatography accurate mass time-of-flight mass spectrometry[J].Journal of Chromatography A,2009, 46: 8206-9216.
[24] Reeves Philip T. Drug Residues[J]. Comparative and Veterinary Pharmacology, 2010, 199: 265-290.
[25] Van Dresser W R, Wilcke J R. Drug residues in food animals[J]. Journal of the American Veterinary Medical Association, 1989, 12: 1700-1710.
[26] Chonan Takao, Nishimura Kazuhiko, Hirama Yuzi. Rapid determination of residues of five kinds of veterinary drugs in livestock products by HPLC[J]. Shokuhin Eiseigaku Zasshi, 2000, 5: 326-329.
[27] Sinigoj-Gacnik K,Cerkvenik-Flajs V, Vadnjal S. Evidence of veterinary drug residues in Slovenian freshwater fish[J]. Bulletin of Environmental Contamination and Toxicology, 2005, 1: 109-114.
[28] Martinez Vidal Jose Luis, Garrido Frenich Antonia, Aguilera-Luiz Maria M, et al. Development of fast screening methods for the analysis of veterinary drugresidues in milk by liquid chromatography-triple quadrupole mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2010, 7: 2777-2790.
[29] Haughey SA, Baxter CA. Biosensor screening for veterinary drug residues in foodstuffs[J]. Journal of aoac international, 2006, 3: 862-867.
[30] Edder Patrick, Ortelli Didier, Corvi Claude. Potential of LC-ESI-MS/MS for veterinary drug residues analysis[J]. Mitteilungen aus Lebensmitteluntersuchung und Hygiene, 2003, 6: 534-545.
[31] Guo De-Hua, Deng Xiao-Jun, Zhao Shan-Zhen, et al. Simultaneous Determination of 76 Veterinary Drug Residues in Foodstuffs of Animal Origin by Solid Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, 2010, 3: 318-324.
[32] Wang Lian, Li Yuan-Qian, Wang Hai-Bo. Simultaneous Determination of Twenty Veterinary Drug Residues in Milk and Meat Using Matrix Solid Phase Dispersion-Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, 2011, 2: 203-207.
[33] Tang Hubert Po-on, Ho Clare, Lai Shirley Sau-ling. High-throughput screening for multi-class veterinary drug residues in animal muscle using liquid chromatography/tandem mass spectrometry with on-line solid-phase extraction[J]. Rapid Communications in Mass Spectrometry, 2006, 17: 2565-2572.
[34] Aguilera-Luiz M. M., Martinez Vidal Jose Luis, Romero-Gonzalez Roberto. Multi-residue determination of veterinary drugs in milk by ultra-high-pressure liquid chromatography-tandem mass spectrometry[J]. Journal of Chromatography, 2008, 1-2: 10-16.
[35] Martinez Vidal Jose Luis,Garrido Frenich Antonia, Aguilera-Luiz Maria M, et al. Development of fast screening methods for the analysis of veterinary drug residues in milk by liquid chromatography-triple quadrupole mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2010, 7: 2777-2790.
[36] Balizs G, Hewitt A. Determination of veterinary drug residues by liquid chromatography and tandem mass spectrometry[J]. Analytica Chimica Acta,2003, 1-2: 105-131 .
[37] Gentili A; Perret D, Marchese S. Liquid chromatography-tandem mass spectrometry for performing confirmatory analysis of veterinary drugs in animal-food products[J]. Trac-trends in Analytical Chemistry, 2005, 7: 704-733.
[38] Tagiri-Endo Misako, Yanagita Noriaki. Simultaneous determination of residual veterinary drugs in muscle by on-line solid phase extraction/high-performance liquid chromatography/tandem mass spectrometry[J]. Bunseki Kagaku, 2007, 5: 317-326.
[39] Garrido Frenich Antonia,del Mar Aguilera-Luiz Maria, Martinez Vidal Jose Luis, et al. Comparison of several extraction techniques for multiclass analysis of veterinary drugs in eggs using ultra-high pressure liquid chromatography-tandem mass spectrometry[J]. Analytica Chimica Acta, 2010, 2: 150-160.
[40] Boscher Aurore, Guignard Cedric, Pellet Terence et al. Development of a multi-class method for the quantification of veterinary drug residues in feedingstuffs by liquid chromatography-tandem mass spectrometry[J].Journal of Chromatography A, 2010, 41: 6394-6404.
[41] Thompson T. S.,Noot D. K., Kendall J. D. Surveillance study of novobiocin and phenylbutazone residues in raw bovine milk using liquid chromatography-tandem mass spectrometry[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 2010, 8, 1104-1111.
[42] Khong SP, Gremaud E, Richoz J, et al. Analysis of matrix-bound nitrofuran residues in worldwide-originated honeys by isotope dilution high-performance liquid chromatography-tandem mass spectrometry[J]. Journal of Agricultural and Food Chemistry, 2004, 17: 5309-5315.
[43] Shen Jianzhong, Guo Liming, Xu Fei, et al. Simultaneous Determination of Fluoroquinolones, Tetracyclines and Sulfonamides in Chicken Muscle by UPLC-MS-MS[J]. Chromatographia, 2010 , 5-6: 383-388.
[44] Liu Yong-Jun,Wu Yin-Liang, Jiang Yan-Bin, et al. Determination of New Veterinary Drug Tulathromycin Residues in Pork by High Performance Liquid Chromatography Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, 2009, 10: 1489-1493.
[45] Cronly M., Behan P., Foley B., et al. Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS)[J].Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2010, 9: 1233-1246.
[46] Tian Hongzhe. Determination of chloramphenicol, enrofloxacin and 29 pesticides residues in bovine milk by liquid chromatography-tandem mass spectrometry[J]. Chemosphere, 2011, 3: 349-355.
[47] Chen Dongmei, Tao Yanfei, Liu Zhaoying, et al. Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of glucocorticoid residues in edible tissues of swine, cattle, sheep, and chicken[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2010, 10: 1363-1371.
[48] Wiest Laure, Bulete Audrey, Giroud Barbara, et al. Multi-residue analysis of 80 environmental contaminants in honeys, honeybees and pollens by one extraction procedure followed by liquid and gas chromatography coupled with mass spectrometric detection[J].Journal of Chromatography A, 2011, 34: 5743-5756.
[49] Stolker AAM;, Brinkman UAT. Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals - a review[J]. Journal of Chromatography A, 2005, 1-2: 15-53.
[50] Mottier P, Khong SP, Gremaud E, et al. Quantitative determination of four nitrofuran metabolites in meat by isotope dilution liquid chromatography-electrospray ionisation-tandem mass spectrometry[J]. Journal of Chromatography A, 2005, 1-2: 85-91.
[51] Turnipseed Sherri B., Andersen Wendy C., Karbiwnyk Christine M., et al.Multi-class, multi-residue liquid chromatography/tandem mass spectrometry screening and confirmation methods for drug residues in milk[J]. Rapid Communications in Mass Spectrometry, 2008, 22: 1467-1480.
[52] Xu CL, Chu XG, Peng CF, et al. Development of a faster determination of 10 anabolic steroids residues in animal muscle tissues by liquid chromatography tandem mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis, 2006, 41: 616-621.
[53] Cheng Kaipeng, Wang Sufang, Guo Kangquan, et al. Analysis of Nanafrocin in Foodstuffs of Animal Origin by LC-MS-MS[J]. Chromatographia, 2010, 5-6: 389-395.
[54] Xia Xi, Li Xiaowei, Shen Jianzhong. Determination of nitroimidazole residues in porcine urine by liquid chromatography/tandem mass spectrometry[J]. Journal of Aoac International, 2006, 4: 1116-1119.
[55] Bogialli Sara, Di Corcia Antonio, Lagana Aldo, et al. A simple and rapid confirmatory assay for analyzing antibiotic residues of the macrolide class and lincomycin in bovine milk and yoghurt: hot water extraction followed by liquid chromatography/tandem mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2007, 2: 237-246.
[56] Cherlet M, Schelkens M, Croubels S, et al. Quantitative multi-residue analysis of tetracyclines and their 4-epimers in pig tissues by high-performance liquid chromatography combined with positive-ion electrospray ionization mass spectrometry[J]. Analytica Chimca Acta, 2003, 1-2 : 199-213.
[57] Saito Mizue, Kozutsumi Daisuke, Kawasaki Michiko, et al. Multiresidue method for pesticides and veterinary drugs in bovine milk using GC/MS and LC/MS/MS. Shokuhin Eiseigaku Zasshi[J]. Journal of the Food Hygienic Society of Japan , 2008, 3: 228-38.
[58] Wang Fengmei, Chen Junhui, Cheng Hongyan, et al. Multi-residue method for the confirmation of four avermectin residues in food products of animal origin by ultra-performance liquid chromatography-tandem mass spectrometry[J]. Food Additives and Contaminants Part A-chemistry AnalysisControl Exposure& Risk Assessment, 2011, 5: 627-639.
[59] Bonvehi I. Serra, Gutierrez A. Lacalle. Residues of antibiotics and sulfonamides in honeys from Basque Country (NE Spain) [J].Journal of the science of food and Agriculture, 2009, 1, 63-72.
[60] Pedersen Mikael, Andersen Jens Hinge. Confirmatory analysis of steroids in muscle using liquid chromatography-tandem mass spectrometry[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2011, 4, 428-437.
[61] Shao Bing, Cui Xiaoliang, Yang Yi, et al. Validation of a Solid-Phase Extraction and Ultra-Performance Liquid Chromatographic Tandem Mass Spectrometric Method for the Detection of 16 Glucocorticoids in Pig Tissues[J]. Journal of Aoac International, 2009, 2: 604-611.
[62] Liu Yanhua, Zhang Chunping, Men Liqiang, et al.Determination of tetracycline antibiotics residues in chicken muscle by liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2006, 2: 171-173.
[63] Martinez Vidal Jose Luis, del Mar Aguilera-Luiz Maria, Romero-Gonzalez Roberto, et al. Multiclass Analysis of Antibiotic Residues in Honey by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry[J]. Journal of Agricultural and Food Chemistry, 2009, 5: 1760-1767.
[64] Hoff Rodrigo Barcellos, Barreto Fabiano, Kist Tarso B. Ledur. Use of capillary electrophoresis with laser-induced fluorescence detection to screen and liquid chromatography-tandem mass spectrometry to confirm sulfonamide residues: Validation according to European Union 2002/657/EC[J]. Jounal of Chromatography A, 2009, 46: 8254-8261.
[65] Bogialli Sara, Ciampanella Cecilia, Curini Roberta, et al. Development and validation of a rapid assay based on liquid chromatography-tandem mass spectromtetry for determining macrolide antibiotic residues in eggs[J]. Jounal of Chromatography A, 2009, 40: 6810-6815.
[66] Sniegocki Tomasz, Posyniak Andrzej; Zmuiezki Jan, et al. Determination ofnitrofuran metabolite residues in eggs by liquid chromatography-mass spectrometry[J]. Bulletin of the Veterinary Institute in Pulawy, 2008, 3: 421-425.
[67] Zeleny Reinhard,Harbeck Stefan,Schimmel Heinz. Validation of a liquid chromatography-tandem mass spectrometry method for the identification and quantification of 5-nitroimidazole drugs and their corresponding hydroxy metabolites in lyophilised pork meat[J]. Jounal of Chromatography A, 2009, 2 : 249-256.
[68] Guo Liming, Zhu Kui, Jiang Haiyang,et al. Simultaneous determination of tetracyclines, sulfonamides and quinolones residues in chicken livers by ultra performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2009, 4: 412-416.
[69] De Ruyck Hendrik, De Ridder Herman. Determination of tetracycline antibiotics in cow's milk by liquid chromatography/tandem mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2007, 9: 1511-1520.
[70] Kinsella Brian, Whelan Michelle, Cantwell Helen,et al. A dual validation approach to detect anthelmintic residues in bovine liver over an extended concentration range[J]. Talanta, 2010, 1: 14-24.
[71] Mastovska Katerina. Multiresidue Analysis of Antibiotics in Food of Animal Origin Using Liquid Chromatography-Mass Spectrometry[J]. Mass Spectrometry in Food Safety: Methods and Protocols, 2011, 747: 267-307.
[72] Ding Tao,Xu Jinzhong, Shen Chongyu, et al. Determination of metabolites of nitrofuran antibiotics in royal jelly by high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2006, 5: 432-435.
[73] Shao Bing, Jia Xiaofei, Wu Yongning, et al. Multi-class confirmatory method for analyzing trace levels of tetracyline and quinolone antibiotics in pig tissues by ultra-performance liquid chromatography coupled with tandem mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2007, 21:3487-3496.
[74] Bogialli S, Curini R, Di Corcia A, et al. Simple confirmatory assay for analyzing residues of aminoglycoside antibiotics in bovine milk: hot water extraction followed by liquid chromatography-tandem mass spectrometry[J]. Jounal of Chromatography A, 2005, 1-2: 93-100.
[75] Li Yong, Gao ZhiXian, Dong FangTing, et al. Quantitative Determination of Quinocetone and Its Metabolites in Chicken Plasma by Liquid Chromatography/Tandem Mass Spectrometry[J]. Journal of Aoac International, 2008, 6: 1494-1498.
[76] Van Rhijn JA, Lasaroms JJP, Berendsen BJA,et al. Liquid chromatographic-tandem mass spectrometric determination of selected sulphonamides in milk[J]. Jounal of Chromatography A, 2002, 1-2: 121-133.
[77] Durden David A., MacPherson Tanya. Quantitation and validation of fluoroquinolones in eggs using liquid chromatography/tandem mass spectrometry[J]. Journal of Aoac International, 2007, 2: 613-625.
[78] Berardi G, Bogialli S, Curini R,et al. Evaluation of a method for assaying sulfonamide antimicrobial residues in cheese: Hot-water extraction and liquid chromatography-tandem mass spectrometry[J]. Journal of Agricultural and Food Chemistry, 2006, 13: 4537-4543.
[79] Yuan Yuan; Xu Chuanlai, Peng Chifang, et al. Analytical Methods for the Detection of Corticosteroids-Residues in Animal-Derived Foodstuffs[J]. Critical Reviews in Analytical Chemistry, 2008, 4: 227-241.
[80] Li Hui, Kijak Philip J. Development of a Quantitative Multiclass/Multiresidue Method for 21 Veterinary Drugs in Shrimp[J]. Journal of Aoac International, 2011, 2: 394-406.
[81] Hermo MP, Barron D, Barbosa J. Development of analytical methods for multiresidue determination of quinolones in pig muscle samples by liquid chromatography with ultraviolet detection, liquid chromatography-mass spectrometry and liquid chromagraphy-tandem mass spectrometry[J]. Jounal of Chromatography A, 2006, 1-2: 132-139.
[82] Junza A., Amatya R.,Barron D., et al. Comparative study of the LC-MS/MS and UPLC-MS/MS for the multi-residue analysis of quinolones, penicillins and cephalosporins in cow milk, and validation according to the regulation 2002/657/EC[J]. Journal of Chromatography B-analytical Technologies in the Biomedical and Life Sciences, 2011, 25: 2601-2610.
[83] Tkacikova Sona, Kozarova Ivona, Mate Dionyz. Liquid chromatography tandem mass spectrometry determination of maduramycin residues in the tissues of broiler chickens[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2010, 9: 1226-1232.
[84] Martinez-Villalba Anna, Moyano Encarnacion, Martins Claudia P. B., et al. Fast liquid chromatography/tandem mass spectrometry (highly selective selected reaction monitoring) for the determination of toltrazuril and its metabolites in food[J]. Analytical and Bioanalytical Chemistry, 2010, 7: 2893-2901.
[85] Arroyo David, Cruz Ortiz M., Sarabia Luis A., et al. Determination and identification, according to European Union Decision 2002/657/EC, of malachite green and its metabolite in fish by liquid chromatography-tandem mass spectrometry using an optimized extraction procedure and three-way calibration[J]. Jounal of Chromatography A, 2009, 29: 5472-5482.
[86] Zhang Xiaojun, Xu Hanxiang, Zhang Hong, et al. Simultaneous determination of albendazole and its metabolites in fish muscle tissue by stable isotope dilution ultra-performance liquid chromatography tandem mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2011, 2: 727-734.
[87] De la Cruz Marcia N. S., Soares Renata F., Marques Anna Sylvia F., et al. Development and Validation of Analytical Method for Sulfonamide Residues in Eggs by Liquid Chromatography Tandem Mass Spectrometry based on the Comission Decision 2002/657/EC[J]. Journal of the Brazilian Chemical Society, 2011, 3: 454-461.
[88] Martos Perry A., Lehotay Steven J., Shurmer Bryn, et al. Ultratrace analysis ofnine macrolides, including tulathromycin A (Draxxin), in edible animal tissues with minicolumn liquid chromatography tandem mass spectrometry[J]. Journal of Agricultural and Food Chemistry, 2008 , 19: 8844-8850.
[89] Cronly Mark, Behan Patrice, Foley Barry, et al. Survey of 11 nitroimidazole residues in hen and duck eggs from the Irish market[J]. Food Additives& Contaminants Part B-surveillance, 2011, 2: 79-87.
[90] Bilandzic Nina, Kolanovic Bozica Solomun, Varenina Ivana, et al. Veterinary drug residues determination in raw milk in Croatia[J]. Food Control, 2011, 12: 1941-1948.
[91] Lee Jung-Bin, Back Yu-Mi, Her Jae-Young, et al. AGFD 127-Analysis of sulfonamide and quinolone antibiotic residues in milk using microbial assays and high performance liquid chromatography (HPLC) [J]. Abstracts of Papers of the American Chemical Society, 2007, 234: 127-AGFD.
[92] Chitescu C. L., Nicolau A. I., Csuma A., et al. Simultaneous analysis of four sulfonamides in chicken muscle tissue by HPLC[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2011, 8: 1013-1020.
[93] Won So Young, Lee Chang Hee, Chang Hye Sook, et al. Monitoring of 14 sulfonamide antibiotic residues in marine products using HPLC-PDA and LC-MS/MS[J]. Food Control, 2011, 7: 1101-1107.
[94] Bialk-Bielinska Anna, Siedlewicz Grzegorz, Stepnowski Piotr, et al. A very fast and simple method for the determination of sulfonamide residues in seawaters[J]. Analytical Methods, 2011, 6: 1371-1378.
[95] Jesus Garcia-Galan M., Silvia Diaz-Cruz M., Barcelo Damia. Occurrence of sulfonamide residues along the Ebro river basin Removal in wastewater treatment plants and environmental impact assessment[J]. Environment International, 2011, 2: 462-473.
[96] Kowalski Piotr, Plenis Alina, Oledzka Ilona, et al. Optimization and validation of the micellar electrokinetic capillary chromatographic method for simultaneous determination of sulfonamide and amphenicol-type drugs inpoultry tissue[J]. Journal of Pharmaceutical and Biomedical Analysis, 2011, 1: 160-167.
[97] Roudaut B, Garnier M. Sulphonamide residues in eggs following drug administration via the drinking water[J]. Food Additives and Contaminants, 2002, 4: 373-378.
[98] Perret D, Gentili A, Marchese S, et al. Sulphonamide residues in Italian surface and drinking waters: A small scale reconnaissance[J]. Chromatographia, 2006, 5-6: 225-232.
[99] Roudaut B, Moretain J P. Sulphonamide residues in milk of dairy cows following intravenous injection[J]. Food Additives and Contaminants , 1990, 4: 527-533.
[100] Finlay E M, Games D E, Startin J R, et al. Screening, confirmation, and quantification of sulphonamide residues in pig kidney by tandem mass spectrometry of crude extracts[J]. Biomedical & Environmental Mass Spectrometry, 1986, 11: 633-639.
[101] Herrera-Herrera Antonio V., Hernandez-Borges Javier, Angel Rodriguez-Delgado Miguel. Fluoroquinolone antibiotic determination in bovine, ovine and caprine milk using solid-phase extraction and high-performance liquid chromatography-fluorescence detection with ionic liquids as mobile phase additives[J]. Jounal of Chromatography A, 2009, 43: 7281-7287.
[102] Schneider MJ. Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using automated microdialysis-liquid chromatography[J].Journal of Chromatographic Science, 2011, 8: 351-356.
[103] Choi J, Yee AJ, Thompson D, et al. Determination of fluoroquinolone residues in animal tissues using Escherichia coli as indicator organism[J]. Journal of Aoac International, 1999, 6: 1407-1412.
[104] Beeton Michael L., Chalker Victoria J., Kotecha Sailesh, et al. Comparison of full gyrA, gyrB, parC and parE gene sequences between all Ureaplasma parvum and Ureaplasma urealyticum serovars to separate true fluoroquinoloneantibiotic resistance mutations from non-resistance polymorphism[J]. Journal of Antimicrobial Chemotherapy, 2009, 3: 529-538.
[105] Ashwin Helen, Stead Sara, Caldow Marianne, et al. A rapid microbial inhibition-based screening strategy for fluoroquinolone and quinolone residues in foods of animal origin[J]. Analytica Chimica Acta, 2009 , 1-2: 241-246.
[106] Mohan J, Sastry KVH, Tyagi JS, et al. Residues of fluoroquinolone drugs in the cloacal gland and other tissues of Japanese quail[J]. British Poultry Science, 2006, 1: 83-87.
[107] Fernandez Fatima, Pinacho Daniel G., Sanchez-Baeza Francisco, et al. Portable Surface Plasmon Resonance Immunosensor for the Detection of Fluoroquinolone Antibiotic Residues in Milk[J]. Journal of Agricultural and Food Chemistry, 2011, 9: 5036-5043.
[108] Kanda Maki, Kusano Tomoto, Kanai Setsuko, et al. Rapid Determination of Fluoroquinolone Residues in Honey by a Microbiological Screening Method and Liquid Chromatography[J]. Journal of Aoac International, 2010, 4, 1331-1339.
[109] Schneider MJ, Donoghue DJ. Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using liquid chromatography-fluorescence-multiple mass spectrometry[J]. Journal of Chromatography B-analytical Technologies in the Biomedical and Life Sciences, 2002, 1: 83-92.
[110] Tang Qingfa, Yang Tongtong, Tan Xiaomei, et al .Simultaneous Determination of Fluoroquinolone Antibiotic Residues in Milk Sample by Solid-Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometry[J]. Journal of Agricultural and Food Chemistry, 2009, 11: 4535-4539.
[111] Tang Qingfa, Yang Tongtong, Tan Xiaomei, et al. Simultaneous Determination of Fluoroquinolone Antibiotic Residues in Milk Sample by Solid-Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometr[J]. Journal of Agricultural and Food Chemistry, 2009, 11: 4535-4539.
[112] McMullen Sarah E., Schenck Frank J., Vega Victor A. Rapid Method for the Determination and Confirmation of Fluoroquinolone Residues in Catfish Using Liquid Chromatography/Fluorescence Detection and Liquid Chromatography-Tandem Mass Spectrometry[J]. Journal of aoac international, 2009, 4: 1233-1240.
[113] Guo Wei, Liu Yong, Liu Ning. Simultaneous analysis of 7 fluoroquinolone residues in chicken muscle by ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2009, 4: 406-411.
[114] Adrian Javier, Pasche Stephanie, Pinacho Daniel G., et al. Wavelength-interrogated optical biosensor for multi-analyte screening of sulfonamide, fluoroquinolone, beta-lactam and tetracycline antibiotics in milk[J]. Trac-trends in Analytical Chemistry, 2009, 6: 769-777.
[115] Guo Genhe, Pan Wei, Su Desen, et al. Simultaneous determination of four fluoroquinolone residues in fish by ion-pair high performance liquid chromatography[J].Chinese Journal of Chromatography, 2005, 4: 401-403.
[116] Choi Jeong Heui, El-Aty A. M. Abd, Shen Jing Yu, et al. Analysis of fluoroquinolone residues in edible chicken tissues using supercritical fluid extraction[J]. Berliner Und Munchener Tierarztliche Wochenschrift, 2006,11-12: 456-460.
[117] Cronly M., Behan P., Foley B., et al. Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS) [J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 2010, 9: 1233-1246.
[118] Wang Yabin, He Fangyang,Wan Yuping,et al. Indirect competitive enzyme-linked immuno-sorbent assay (ELISA) for nitroimidazoles in food products[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 2011, 5: 619-626.
[119] Capitan-Vallvey LF, Ariza A, Checa R, et al. Determination of fivenitroimidazoles in water by liquid chromatography-mass spectrometry[J]. Journal of Chromatography A, 2002, 1-2: 243-248.
[120] Gui Yi, Ni Yong Nian, Kokot Serge. Simultaneous determination of three 5-nitroimidazoles in foodstuffs by differential pulse voltammetry and chemometrics[J]. Chinese Chemical Letters, 2011, 5: 591-594.
[121] Cronly Mark, Behan Patrice,Foley Barry, et al. Development and validation of a rapid method for the determination and confirmation of 10 nitroimidazoles in animal plasma using liquid chromatography tandem mass spectrometry[J]. Journal of Chromatography B-analytical Technologies in the Biomedical and Life Sciences, 2009, 14-15: 1494-1500.
[122] Hack T, Georgi K, Speer K. Confirmatory method for the verification of Nitroimidazoles in eggs[J]. Deutsche Lebensmittel-rundschau, 2003, 6: 231-235.
[123] Wang Hai, Wang Zijian, Liu SuYing, et al. Quantification of Nitroimidazoles Residues in Swine Liver by Liquid Chromatography-Mass Spectrometry with Atmospheric Pressure Chemical Ionization[J]. Bulletin of Environmental Contamination and Toxicology, 2009, 4: 411-414.
[124] Shen JZ, Yhang Y, Zhang SX, et al. Determination of nitroimidazoles and their metabolites in swine tissues by liquid chromatography[J]. Journal of Aoac international, 2003,3: 505-509.
[125] Huet AC, Mortier L, Daeseleire E, et al. Development of an ELISA screening test for nitroimidazoles in egg and chicken muscle[J]. Analytica Chimica Acta, 2005, 1: 157-162.
[126] Hurtaud-Pessel D, Delepine B, Laurentie M. Determination of four nitroimidazole residues in poultry meat by liquid chromatography-mass spectrometry[J]. Journal of Chromatography A, 2000, 1-2: 89-98.
[127] Xia Xi, Li Xiaowei, Shen Jianzhong, et al. Determination of nitroimidazole residues in porcine urine by liquid chromatography/tandem mass spectrometry[J]. Journal of aoac international, 2006, 4: 1116-1119.
[128] Semeniuk S, Posyniak A, Niedzielska J, et al. Determination of nitroimidazoleresidues in poultry tissues, serum and eggs by high-performance liquid chromatography[J]. Biomedical Chromatography, 1995, 5: 238-42.
[129]潘媛媛,史亚利,蔡亚岐.高效液相色谱-串联质谱技术分析人血液中的全氟化合物.第五届全国环境化学大会, 2009, 408.
[130]金明. UPLC-MS/MS测定牛肝中七种磺胺类药物的研究.甘肃农业大学硕士毕业论文, 2008.
[131]崔海滨,刘晓丽,徐榕蔓等.超高效液相色谱-串联质谱技术检测番茄制品中矮壮素及缩节胺残留量的方法研究[J].福建分析测试, 2009, 18: 20-24.
[132]张瑾.动物性食品中兽药残留的原因、危害及控制对策[J].吉林畜牧兽医,2009,30:1-7.
[133]沈建忠.动物性食品中兽药残留与检测.农民日报, 2004, (11月3日,第6版)
[134]陈杖榴,曾振灵.对我国动物源性食品中兽药残留问题的思考[J].中国动物保健, 2003, 12: 8-12.
[135]王少敏,邹大鹏,张建业等.高效液相色谱/串联质谱法快速鉴定Z / E盐酸头孢吡肟异构体[J].分析化学研究简报, 2006, 34: 1278-1282.
[136]张丽军,姚亚敏,孙建军等.高效液相色谱-串联质谱法同时测定奈韦拉平、拉米夫定、司他夫定、齐多夫定和依非韦伦的血药浓度[J].中国临床药理学杂志, 2010, 26: 133-136.
[137]孙俊杰.高效液相色谱-质谱联用在药物分析中的应用.中国科学技术大学硕士学位论文, 2010.
[138]王俊菊,高木珍,包建民.高效液相色谱串联质谱技术在兽药残留检测中的应用进展[J].中国兽药杂志, 2011, 45: 45-51.
[139]罗亚男.高效液相色谱串联质谱技术在药物分析中的应用.中国科学技术大学硕士学位论文, 2011.
[140]张宪忠,孙红文,汪磊等.固相萃取高效液相色谱串联质谱技术测定污水中的全氟化合物[J].环境化学, 2009, 28: 944-945.
[141]杨秋红,钱蜀,程小艳等.固相萃取地表水中痕量联苯胺及HPLC-MS测定[J].化学研究与应用, 2011, 23: 102-106.
[142]吕桂霞,刁有祥,许胜勇.建立完善的兽药残留监控体系势在必行[J].中国兽药杂志, 2002, 36: 7-9.
[143]刘佳佳,佘永新,刘洪斌等.聚醚类抗生素残留检测技术及其研究进展[J].食品工业科技, 2011, 32: 440-444.
[144]余华,严玉宝,谢晶等.酶联免疫分析技术及其在进出口动物产品兽药残留检测中的应用[J].中国畜牧兽医, 2010, 37: 76-79.
[145]郝贵增,龙淼.肉类食品中兽药残留快速检测研究进展[J].肉类研究, 2008, 6: 64-66.
[146]刘丹.生物样品中阿德福韦等4种药物的LC/MS/MS测定方法的研究及应用.沈阳药科大学博士学问论文, 2006.
[147]董义春.食品安全与兽药残留监控[J].中国兽药杂志,2009,43: 24-28.
[148]魏红波,李崇瑛,闫海全.食品中抗生素类兽药残留的分析方法[J].粮食与饲料工业, 2008, 4: 42-44.
[149]陆辉,郑义,卢军锋.兽药残留的危害及对策[J].泰州职业技术学院学报, 2008, 8: 75-78.
[150]杨成对,宋莉晖.双酚A残留的检测方法研究[J].食品科学, 2008, 29: 316-317.
[151]栾晓蕊,张婷,吴霞等.利用液相色谱串联质谱技术检测卵巢上皮性癌血清标记物的研究[J].现代妇产科进展, 2010, 19: 510-513.
[152]龚炜.烟草中农药残留的液相色谱一串联质谱分析方法研究.郑州大学硕士学位论文, 2007.
[153]杨方,庞国芳,刘正才等.液相色谱-串联质谱法检测水产品中15种喹诺酮类药物残留量[J].分析实验室, 2008, 27: 27-33.
[154]毛友安,钟科军,魏万之等.液相色谱-串联质谱技术测定卷烟烟气中烟草特有亚硝胺[J].现代科学仪器, 2006, 1: 88-90.
[155]谢萍.液相色谱--串联质谱技术用于塑料包装材料中增塑剂迁移检测的研究.吉林大学博士学位论文, 2008.
[156]聂芳红,徐晓彬,陈进军.食品动物兽药残留的研究进展[J].中国农学通报, 2006, 22: 71-75.
[157]孙雷,刘琪,王树槐.液相色谱--串联质谱技术进展及在兽药行业上的应用[J].中国兽药杂志, 2007, 41:34-37.
[158]胡万群,许毓,刘飞等.液质联用检测人体血浆中的阿奇霉素[J].高等学校化学学报, 2007, 28: 2046-2050.
[159]孟芳.液相色谱--串联质谱法定量分析血浆中四种抗生素药物研究.沈阳药科大学硕士学位论文, 2005.
[161]马洪宝.兽药残留对动物性食品安全的影响[J].中国动物检疫, 2007, 2: 21-22.
[162]丁晓刚,赵劲航,卫澜欣,等.兽药残留对人类健康的危害[J].中国动物保健, 2007, 02: 67-68.
[163]岳振峰,林秀云,唐少冰,等.高效液相色谱-串联质谱法测定动物组织中的16种喹诺酮类药物残留[J].色谱, 2007, 25(4): 491-495.
[164]岳振峰,谢丽琪,陈小霞,等.牛奶中16种喹诺酮类药物残留量的高效液相色谱-串联质谱法测定[J].分析测试学报, 2008, 27(3): 240-243.
[165]李爱军,王明泰,牟峻,等.食品中野燕枯残留量的测定[J].农药, 2006, 45(12): 842-845.
[166]卢利军,周晓,韩大川,等.液相色谱串联质谱法测定纺织品和皮革中PFOS含量[J].印染助剂, 2009, 26(10): 50-53.
[167]谢萍,宋慧,刘英杰,等.液相色谱串联质谱法研究小刺猴头菌子实体中污染物增塑剂[J].高等学校化学学报, 2007, 28(11): 2040-2045.
[168]王明泰,牟峻,吴剑等.GC-MS法测定粮谷及油料中55种有机磷农药残留量[J].分析实验室,2006,25(11):110-117.
[169]王明泰,牟峻,靳颖等.GPC净化处理在测定拟除虫菊酯残留量中的应用[J].印染,2007,(6):37-40.
[170]甘宾宾,汤艳荣,蒋世琼.高效液相色谱--质谱联用技术在食品安全中的应用及进展[J].化工技术与开发, 2009, 38(12):33-37.
[171]唐林林.蜂群用药对蜂蜜中药物残留影响的研究[硕士学位论文].福建:福建农林大学,2008.
[172]王明泰,牟峻,靳颖等.纺织品有机氮农药残留量的LC MS/MS测定法[J].印染,2007,(8):31-35.
[173]王建华.食品中农药残留和常见重点有机污染物检测技术的研究和应用[博士研究生学位论文].中国海洋大学,2007.
[174]陈宝明.浅谈兽药残留的种类及危害.北方牧业,2003.12.30.
[175]李爱军,王明泰,牟峻等.气相色谱--质谱联用法测定水果中四螨嗪残留量[J].理化检验(化学分册),2008, 44: 323-325.
[176]陈敏艳,孙涛,王香敏.兽药残留及其危害[J].动物医学进展,2005,26(10):111-113.
[177]姜力,文学忠,钟雯.兽药残留与食品安全[J].吉林畜牧兽医,2011,32(5):1-9.
[178]李爱军,王明泰,牟峻等.植物源性饲料中燕麦枯残留量的测定[J].粮食与饲料工业,2008,(6):42-44.
[179]谢萍.液相色谱--串联质谱技术用于塑料包装材料中增塑剂迁移检测的研究[博士研究生学位论文].长春:吉林大学,2008.
[180]王志元,张思群,席静等.水果及果汁中二恶英类似物三氯新残留量的超高效液相色谱--串联质谱检测方法研究[J].中国卫生检验杂志,2011,21(6):1325-1327.
[181]王明泰,牟峻,吴剑等.蔬菜及水果中77种有机磷和氨基甲酸酯农药残留量检测技术研究[J].食品科学,2007,28(3):247-253.
[182]郭德华,邓晓军,赵善贞等.固相萃取--高效液相色谱/串联质谱同时检测动物源性食品中76种兽药残留[J].分析化学研究报告,2010, 38(3):318-324.
[183]曹军,陈勇,杨瑞章等.分散固相萃取--高效液相色谱--串联质谱法测定水产品中19种喹诺酮类兽药残留[J].中国兽药杂志,2011,45(7):21-25.
[184]石威.不同生长期人参中化学成分及农药残留的研究[博士研究生学位论文].长春:吉林大学,2007.
[185]王钟.气相色谱--质谱法测定蔬菜中有机磷农药和氨基甲酸脂类农药残留的研究[研究生学位论文].济南:山东大学,2010.
[186]丁力.有机污染物的色谱-质谱联用检测新方法研究与应用[研究生学位论文].衡阳:南华大学,2008.
[187]李春风,岳振峰,赵凤娟等.液相色谱串联质谱测定水产品中吩噻嗪类药物残留的研究[J].中国兽医学报,2010,30(3):384-387.
[188]董丹.液相色谱-质谱/质谱测定动物源性食品和水中17种磺胺[硕士学位论文].沈阳:东北大学,2004.
[189]王翔,邓晓军,宋国新等.食品中磺胺类兽药残留前处理技术的研究进展[J].食品科学,2009,30(7):254-257.Yuan ZH. Chinese regulations on veterinary drug residues. 5th Congress of Toxicology in Developing Countries, 2003, 1: 26-27.
[190] Pecorelli I, Bibi R, Fioroni L, et al. Validation of a confirmatory method for the determination of sulphonamides in muscle according to the European Union regulation 2002/657/EC. 27th International Symposium on High-Performance Liquid-Phase Separations and Related Techniques, 2004, 1-2: 23-29.
[191] Kaufmann A., Butcher P., Maden K., et al. Development of an improved high resolution mass spectrometry based multi-residue method for veterinary drugs in various food matrices. 6th International Symposium on Hormone and Veterinary Drug Residue Analysis (VRDA), 2011, 1-2: 86-94.
[192] Kan CA, Petz M. Residues of veterinary drugs in eggs and their distribution between yolk and white. Symposium on Agrochemical Residues in Eggs held during the Fall 1999 National Meeting of the American-Chemical-Society, 2000, 12: 6397-6403.
[193] Reig Milagro, Toldra Fidel. Veterinary drug residues in meat: Concerns and rapid methods for detection, 2008, 1-2: 60-67.
[194] Munoz P, Blanca J, Ramos A, et al. A versatile liquid chromatography-tandem mass spectrometry system for the analysis of different groups of veterinary drugs. 5th Euroresidue Conference, 2005, 1-2: 137-144.
[195] Stubbings George, Bigwood Timothy. The development and validation of a multiclass liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure for the determination of veterinary drug residues in animal tissue using a QuEChERS (QUick, Easy, CHeap, Effective, Rugged and Safe) approach. EuroResidue VI Conference, 2009, 1-2: 68-78.
[196] Xia X., Li X., Zhang S, et al. Confirmation of four nitroimidazoles in porcine liver by liquid chromatography-tandem mass spectrometry. 5th International Symposium on Hormone and Veterinary Drug Residue Analysis, 2007, 1-2:394-398.
[197] Scherpenisse Peter, Bergwerff Aldert A. Determination of residues of tricaine in fish using liquid chromatography tandem mass spectrometry. 5th International Symposium on Hormone and Veterinary Drug Residue Analysis, 2007, 1-2: 407-410.
[198] Pena A, Silva L. J. G., Pereira A, et al. Determination of fluoroquinolone residues in poultry muscle in Portugal. 6th International Conference on Instrumental Methods of Analysis, 2010, 6: 2615-2621.
[199] Posyniak A, Zmudzki J, Semeniuk S. Effects of the matrix and sample preparation on the determination of fluoroquinolone residues in animal tissues. 24th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2000), 2001, 1-2: 89-94.
[200] Oliver L. K., Bigwood T., Stubbings G.. Multiresidue analysis of nitroimidazoles, benzimidazoles and levamisole in food of animal origin. 55th Annual Conference on Current Topics in Veterinary Science, 2001, Supplement A:46.
[2] Reeves P. T. Residues of veterinary drugs at injection sites[J]. Journal of Veterinary Pharmacology and Therapeutics, 2007, 1: 1-17.
[3] Stolker A. A. M., Zuidema T., Nielen M. W. F., et al. Residue analysis of veterinary drugs and growth-promoting agents[J]. Trac-trends in Analytical Chemistry, 2007, 10: 967-979.
[4] Chonan Takao, Fujimoto Toru, Ueno Ken-ichi, et al. Multi-residue method for determination of veterinary drugs and feed additives in meats by HPLC[J]. Journal of the Food Hygienic Society of Japan, 2007, 5: 153-158.
[5] Fitzpatrick S C, Vilim A, Lambert G, et al. Dietary intake estimates as a means to the harmonization of maximum residue levels for veterinary drugs. II. Proposed application to the Free Trade Agreement between the United States and Canada[J]. Regulatory toxicology and pharmacology, 1996, 2: 177-183.
[6] Cerniglia CE, Kotarski S. Evaluation of veterinary drug residues in food for their potential to affect human intestinal microflora[J]. Regulatory Toxicology and Pharmacology, 1999, 3:238-261.
[7] Boxall ABA, Fogg LA, Blackwell PA, et al. Veterinary medicines in the environment[J]. Reviews of Environmental Contamination and Toxicology, 2004, 180:1-91.
[8] Weiss C.,Conte A., Milandri C., et al. Veterinary drugs residue monitoring in Italian poultry: Current strategies and possible developments[J]. Food Control, 2007,9: 1068-1076.
[9] Yamamoto Miyako, Toda Miou, Sugita Takiko, et al. Studies on the results of monitoring of veterinary drug residues in food products of animal origin inJapan and other countries[J]. Bulletin of National Institute of Health Sciences, 2009, 127: 84-92.
[10] Zeleny Reinhard, Ulberth Franz,Gowik Petra, et al. Developing new reference materials for effective veterinary drug-residue testing in food-producing animals[J]. Trac-trends in Analytical Chemistry, 2006, 9: 927-936.
[11] Paige JC; Tollefson L; Miller MA. Health implications of residues of veterinary drugs and chemicals in animal tissues[J].Veterinary Clinics of North America-food Animal Practice,1999,1:31-40
[12] Noguchi Shoichiro, Terada Hisaya, Tamura Yukio. Simultaneous determination of veterinary drugs in livestock foods and Seafoods using liquid chromatography/tandem mass spectrometry[J]. Journal of the Food Hygienic Society of Japan, 2008, 3: 177-188.
[13] Engeli Barbara. Regulation of veterinary drug residues in foodstuffs of animal origin, special case nitrofurans[J]. Mitteilungen aus Lebensmitteluntersuchung und Hygiene, 2003, 6: 527-533.
[14] Tittlemier S. A.,Van de Riet J., Burns G., et al. Analysis of veterinary drug residues in fish and shrimp composites collected during the Canadian Total Diet Study, 1993-2004[J]. Food Additives and Contaminants, 2007, 1: 14-20.
[15] Kennedy D. Glenn, Young Paul B., McCracken Robert J.. Analysis of veterinary drug residues in food: The nitrofuran issue[J]. Mitteilungen aus Leben smitte luntersuchung und Hygiene, 2003, 6: 510-526.
[16] Blasco Cristina, Pico Yolanda, Andreu Vicente. Analytical method for simultaneous determination of pesticide and veterinary drug residues in milk by CE-MS[J]. Electrophoresis, 2009, 10: 1698-1707.
[17] Talley MR. The National Milk Safety Program and drug residues in milk[J]. Veterinary Clinics of North America-food Animal Practice, 1999, 1: 63-+.
[18] Chonan T, Nishimura K, Hirama Y. Rapid determination of residues of five kinds of veterinary drugs in livestock products by HPLC[J]. Journal of the Food Hygienic Society of Japan, 2000, 5: 326-329.
[19] Kabir J, Umoh VJ, Audu-okoh E,et al. Veterinary drug use in poultry farmsand determination of antimicrobial drug residues in commercial eggs and slaughtered chicken in Kaduna State, Nigeria[J]. Food Control, 2004, 2: 99-105.
[20] Stolker AAM, Brinkman UAT. Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals - a review[J]. Journal of Chromatography A, 2005, 1-2: 15-53.
[21] Saito Mizue, Kozutsumi Daisuke, Kawasaki Michiko. Multiresidue method for pesticides and veterinary drugs in bovine milk using GC/MS and LC/MS/MS. Shokuhin eiseigaku zasshi[J]. Journal of the Food Hygienic Society of Japan, 2008, 3: 228-238.
[22] Yoshida Emiko, Shibuya Takahiro, ,Kurokawa Chieko. Quick simultaneous determination of residual veterinary drugs in processed food. Shokuhin eiseigaku zasshi[J]. Journal of the Food Hygienic Society of Japan, 2011, 1: 59-65.
[23] Peters R. J. B., Bolck Y. J. C., Rutgers P. Multi-residue screening of veterinary drugs in egg, fish and meat using high-resolution liquid chromatography accurate mass time-of-flight mass spectrometry[J].Journal of Chromatography A,2009, 46: 8206-9216.
[24] Reeves Philip T. Drug Residues[J]. Comparative and Veterinary Pharmacology, 2010, 199: 265-290.
[25] Van Dresser W R, Wilcke J R. Drug residues in food animals[J]. Journal of the American Veterinary Medical Association, 1989, 12: 1700-1710.
[26] Chonan Takao, Nishimura Kazuhiko, Hirama Yuzi. Rapid determination of residues of five kinds of veterinary drugs in livestock products by HPLC[J]. Shokuhin Eiseigaku Zasshi, 2000, 5: 326-329.
[27] Sinigoj-Gacnik K,Cerkvenik-Flajs V, Vadnjal S. Evidence of veterinary drug residues in Slovenian freshwater fish[J]. Bulletin of Environmental Contamination and Toxicology, 2005, 1: 109-114.
[28] Martinez Vidal Jose Luis, Garrido Frenich Antonia, Aguilera-Luiz Maria M, et al. Development of fast screening methods for the analysis of veterinary drugresidues in milk by liquid chromatography-triple quadrupole mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2010, 7: 2777-2790.
[29] Haughey SA, Baxter CA. Biosensor screening for veterinary drug residues in foodstuffs[J]. Journal of aoac international, 2006, 3: 862-867.
[30] Edder Patrick, Ortelli Didier, Corvi Claude. Potential of LC-ESI-MS/MS for veterinary drug residues analysis[J]. Mitteilungen aus Lebensmitteluntersuchung und Hygiene, 2003, 6: 534-545.
[31] Guo De-Hua, Deng Xiao-Jun, Zhao Shan-Zhen, et al. Simultaneous Determination of 76 Veterinary Drug Residues in Foodstuffs of Animal Origin by Solid Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, 2010, 3: 318-324.
[32] Wang Lian, Li Yuan-Qian, Wang Hai-Bo. Simultaneous Determination of Twenty Veterinary Drug Residues in Milk and Meat Using Matrix Solid Phase Dispersion-Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, 2011, 2: 203-207.
[33] Tang Hubert Po-on, Ho Clare, Lai Shirley Sau-ling. High-throughput screening for multi-class veterinary drug residues in animal muscle using liquid chromatography/tandem mass spectrometry with on-line solid-phase extraction[J]. Rapid Communications in Mass Spectrometry, 2006, 17: 2565-2572.
[34] Aguilera-Luiz M. M., Martinez Vidal Jose Luis, Romero-Gonzalez Roberto. Multi-residue determination of veterinary drugs in milk by ultra-high-pressure liquid chromatography-tandem mass spectrometry[J]. Journal of Chromatography, 2008, 1-2: 10-16.
[35] Martinez Vidal Jose Luis,Garrido Frenich Antonia, Aguilera-Luiz Maria M, et al. Development of fast screening methods for the analysis of veterinary drug residues in milk by liquid chromatography-triple quadrupole mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2010, 7: 2777-2790.
[36] Balizs G, Hewitt A. Determination of veterinary drug residues by liquid chromatography and tandem mass spectrometry[J]. Analytica Chimica Acta,2003, 1-2: 105-131 .
[37] Gentili A; Perret D, Marchese S. Liquid chromatography-tandem mass spectrometry for performing confirmatory analysis of veterinary drugs in animal-food products[J]. Trac-trends in Analytical Chemistry, 2005, 7: 704-733.
[38] Tagiri-Endo Misako, Yanagita Noriaki. Simultaneous determination of residual veterinary drugs in muscle by on-line solid phase extraction/high-performance liquid chromatography/tandem mass spectrometry[J]. Bunseki Kagaku, 2007, 5: 317-326.
[39] Garrido Frenich Antonia,del Mar Aguilera-Luiz Maria, Martinez Vidal Jose Luis, et al. Comparison of several extraction techniques for multiclass analysis of veterinary drugs in eggs using ultra-high pressure liquid chromatography-tandem mass spectrometry[J]. Analytica Chimica Acta, 2010, 2: 150-160.
[40] Boscher Aurore, Guignard Cedric, Pellet Terence et al. Development of a multi-class method for the quantification of veterinary drug residues in feedingstuffs by liquid chromatography-tandem mass spectrometry[J].Journal of Chromatography A, 2010, 41: 6394-6404.
[41] Thompson T. S.,Noot D. K., Kendall J. D. Surveillance study of novobiocin and phenylbutazone residues in raw bovine milk using liquid chromatography-tandem mass spectrometry[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 2010, 8, 1104-1111.
[42] Khong SP, Gremaud E, Richoz J, et al. Analysis of matrix-bound nitrofuran residues in worldwide-originated honeys by isotope dilution high-performance liquid chromatography-tandem mass spectrometry[J]. Journal of Agricultural and Food Chemistry, 2004, 17: 5309-5315.
[43] Shen Jianzhong, Guo Liming, Xu Fei, et al. Simultaneous Determination of Fluoroquinolones, Tetracyclines and Sulfonamides in Chicken Muscle by UPLC-MS-MS[J]. Chromatographia, 2010 , 5-6: 383-388.
[44] Liu Yong-Jun,Wu Yin-Liang, Jiang Yan-Bin, et al. Determination of New Veterinary Drug Tulathromycin Residues in Pork by High Performance Liquid Chromatography Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, 2009, 10: 1489-1493.
[45] Cronly M., Behan P., Foley B., et al. Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS)[J].Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2010, 9: 1233-1246.
[46] Tian Hongzhe. Determination of chloramphenicol, enrofloxacin and 29 pesticides residues in bovine milk by liquid chromatography-tandem mass spectrometry[J]. Chemosphere, 2011, 3: 349-355.
[47] Chen Dongmei, Tao Yanfei, Liu Zhaoying, et al. Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of glucocorticoid residues in edible tissues of swine, cattle, sheep, and chicken[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2010, 10: 1363-1371.
[48] Wiest Laure, Bulete Audrey, Giroud Barbara, et al. Multi-residue analysis of 80 environmental contaminants in honeys, honeybees and pollens by one extraction procedure followed by liquid and gas chromatography coupled with mass spectrometric detection[J].Journal of Chromatography A, 2011, 34: 5743-5756.
[49] Stolker AAM;, Brinkman UAT. Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals - a review[J]. Journal of Chromatography A, 2005, 1-2: 15-53.
[50] Mottier P, Khong SP, Gremaud E, et al. Quantitative determination of four nitrofuran metabolites in meat by isotope dilution liquid chromatography-electrospray ionisation-tandem mass spectrometry[J]. Journal of Chromatography A, 2005, 1-2: 85-91.
[51] Turnipseed Sherri B., Andersen Wendy C., Karbiwnyk Christine M., et al.Multi-class, multi-residue liquid chromatography/tandem mass spectrometry screening and confirmation methods for drug residues in milk[J]. Rapid Communications in Mass Spectrometry, 2008, 22: 1467-1480.
[52] Xu CL, Chu XG, Peng CF, et al. Development of a faster determination of 10 anabolic steroids residues in animal muscle tissues by liquid chromatography tandem mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis, 2006, 41: 616-621.
[53] Cheng Kaipeng, Wang Sufang, Guo Kangquan, et al. Analysis of Nanafrocin in Foodstuffs of Animal Origin by LC-MS-MS[J]. Chromatographia, 2010, 5-6: 389-395.
[54] Xia Xi, Li Xiaowei, Shen Jianzhong. Determination of nitroimidazole residues in porcine urine by liquid chromatography/tandem mass spectrometry[J]. Journal of Aoac International, 2006, 4: 1116-1119.
[55] Bogialli Sara, Di Corcia Antonio, Lagana Aldo, et al. A simple and rapid confirmatory assay for analyzing antibiotic residues of the macrolide class and lincomycin in bovine milk and yoghurt: hot water extraction followed by liquid chromatography/tandem mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2007, 2: 237-246.
[56] Cherlet M, Schelkens M, Croubels S, et al. Quantitative multi-residue analysis of tetracyclines and their 4-epimers in pig tissues by high-performance liquid chromatography combined with positive-ion electrospray ionization mass spectrometry[J]. Analytica Chimca Acta, 2003, 1-2 : 199-213.
[57] Saito Mizue, Kozutsumi Daisuke, Kawasaki Michiko, et al. Multiresidue method for pesticides and veterinary drugs in bovine milk using GC/MS and LC/MS/MS. Shokuhin Eiseigaku Zasshi[J]. Journal of the Food Hygienic Society of Japan , 2008, 3: 228-38.
[58] Wang Fengmei, Chen Junhui, Cheng Hongyan, et al. Multi-residue method for the confirmation of four avermectin residues in food products of animal origin by ultra-performance liquid chromatography-tandem mass spectrometry[J]. Food Additives and Contaminants Part A-chemistry AnalysisControl Exposure& Risk Assessment, 2011, 5: 627-639.
[59] Bonvehi I. Serra, Gutierrez A. Lacalle. Residues of antibiotics and sulfonamides in honeys from Basque Country (NE Spain) [J].Journal of the science of food and Agriculture, 2009, 1, 63-72.
[60] Pedersen Mikael, Andersen Jens Hinge. Confirmatory analysis of steroids in muscle using liquid chromatography-tandem mass spectrometry[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2011, 4, 428-437.
[61] Shao Bing, Cui Xiaoliang, Yang Yi, et al. Validation of a Solid-Phase Extraction and Ultra-Performance Liquid Chromatographic Tandem Mass Spectrometric Method for the Detection of 16 Glucocorticoids in Pig Tissues[J]. Journal of Aoac International, 2009, 2: 604-611.
[62] Liu Yanhua, Zhang Chunping, Men Liqiang, et al.Determination of tetracycline antibiotics residues in chicken muscle by liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2006, 2: 171-173.
[63] Martinez Vidal Jose Luis, del Mar Aguilera-Luiz Maria, Romero-Gonzalez Roberto, et al. Multiclass Analysis of Antibiotic Residues in Honey by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry[J]. Journal of Agricultural and Food Chemistry, 2009, 5: 1760-1767.
[64] Hoff Rodrigo Barcellos, Barreto Fabiano, Kist Tarso B. Ledur. Use of capillary electrophoresis with laser-induced fluorescence detection to screen and liquid chromatography-tandem mass spectrometry to confirm sulfonamide residues: Validation according to European Union 2002/657/EC[J]. Jounal of Chromatography A, 2009, 46: 8254-8261.
[65] Bogialli Sara, Ciampanella Cecilia, Curini Roberta, et al. Development and validation of a rapid assay based on liquid chromatography-tandem mass spectromtetry for determining macrolide antibiotic residues in eggs[J]. Jounal of Chromatography A, 2009, 40: 6810-6815.
[66] Sniegocki Tomasz, Posyniak Andrzej; Zmuiezki Jan, et al. Determination ofnitrofuran metabolite residues in eggs by liquid chromatography-mass spectrometry[J]. Bulletin of the Veterinary Institute in Pulawy, 2008, 3: 421-425.
[67] Zeleny Reinhard,Harbeck Stefan,Schimmel Heinz. Validation of a liquid chromatography-tandem mass spectrometry method for the identification and quantification of 5-nitroimidazole drugs and their corresponding hydroxy metabolites in lyophilised pork meat[J]. Jounal of Chromatography A, 2009, 2 : 249-256.
[68] Guo Liming, Zhu Kui, Jiang Haiyang,et al. Simultaneous determination of tetracyclines, sulfonamides and quinolones residues in chicken livers by ultra performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2009, 4: 412-416.
[69] De Ruyck Hendrik, De Ridder Herman. Determination of tetracycline antibiotics in cow's milk by liquid chromatography/tandem mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2007, 9: 1511-1520.
[70] Kinsella Brian, Whelan Michelle, Cantwell Helen,et al. A dual validation approach to detect anthelmintic residues in bovine liver over an extended concentration range[J]. Talanta, 2010, 1: 14-24.
[71] Mastovska Katerina. Multiresidue Analysis of Antibiotics in Food of Animal Origin Using Liquid Chromatography-Mass Spectrometry[J]. Mass Spectrometry in Food Safety: Methods and Protocols, 2011, 747: 267-307.
[72] Ding Tao,Xu Jinzhong, Shen Chongyu, et al. Determination of metabolites of nitrofuran antibiotics in royal jelly by high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2006, 5: 432-435.
[73] Shao Bing, Jia Xiaofei, Wu Yongning, et al. Multi-class confirmatory method for analyzing trace levels of tetracyline and quinolone antibiotics in pig tissues by ultra-performance liquid chromatography coupled with tandem mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2007, 21:3487-3496.
[74] Bogialli S, Curini R, Di Corcia A, et al. Simple confirmatory assay for analyzing residues of aminoglycoside antibiotics in bovine milk: hot water extraction followed by liquid chromatography-tandem mass spectrometry[J]. Jounal of Chromatography A, 2005, 1-2: 93-100.
[75] Li Yong, Gao ZhiXian, Dong FangTing, et al. Quantitative Determination of Quinocetone and Its Metabolites in Chicken Plasma by Liquid Chromatography/Tandem Mass Spectrometry[J]. Journal of Aoac International, 2008, 6: 1494-1498.
[76] Van Rhijn JA, Lasaroms JJP, Berendsen BJA,et al. Liquid chromatographic-tandem mass spectrometric determination of selected sulphonamides in milk[J]. Jounal of Chromatography A, 2002, 1-2: 121-133.
[77] Durden David A., MacPherson Tanya. Quantitation and validation of fluoroquinolones in eggs using liquid chromatography/tandem mass spectrometry[J]. Journal of Aoac International, 2007, 2: 613-625.
[78] Berardi G, Bogialli S, Curini R,et al. Evaluation of a method for assaying sulfonamide antimicrobial residues in cheese: Hot-water extraction and liquid chromatography-tandem mass spectrometry[J]. Journal of Agricultural and Food Chemistry, 2006, 13: 4537-4543.
[79] Yuan Yuan; Xu Chuanlai, Peng Chifang, et al. Analytical Methods for the Detection of Corticosteroids-Residues in Animal-Derived Foodstuffs[J]. Critical Reviews in Analytical Chemistry, 2008, 4: 227-241.
[80] Li Hui, Kijak Philip J. Development of a Quantitative Multiclass/Multiresidue Method for 21 Veterinary Drugs in Shrimp[J]. Journal of Aoac International, 2011, 2: 394-406.
[81] Hermo MP, Barron D, Barbosa J. Development of analytical methods for multiresidue determination of quinolones in pig muscle samples by liquid chromatography with ultraviolet detection, liquid chromatography-mass spectrometry and liquid chromagraphy-tandem mass spectrometry[J]. Jounal of Chromatography A, 2006, 1-2: 132-139.
[82] Junza A., Amatya R.,Barron D., et al. Comparative study of the LC-MS/MS and UPLC-MS/MS for the multi-residue analysis of quinolones, penicillins and cephalosporins in cow milk, and validation according to the regulation 2002/657/EC[J]. Journal of Chromatography B-analytical Technologies in the Biomedical and Life Sciences, 2011, 25: 2601-2610.
[83] Tkacikova Sona, Kozarova Ivona, Mate Dionyz. Liquid chromatography tandem mass spectrometry determination of maduramycin residues in the tissues of broiler chickens[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2010, 9: 1226-1232.
[84] Martinez-Villalba Anna, Moyano Encarnacion, Martins Claudia P. B., et al. Fast liquid chromatography/tandem mass spectrometry (highly selective selected reaction monitoring) for the determination of toltrazuril and its metabolites in food[J]. Analytical and Bioanalytical Chemistry, 2010, 7: 2893-2901.
[85] Arroyo David, Cruz Ortiz M., Sarabia Luis A., et al. Determination and identification, according to European Union Decision 2002/657/EC, of malachite green and its metabolite in fish by liquid chromatography-tandem mass spectrometry using an optimized extraction procedure and three-way calibration[J]. Jounal of Chromatography A, 2009, 29: 5472-5482.
[86] Zhang Xiaojun, Xu Hanxiang, Zhang Hong, et al. Simultaneous determination of albendazole and its metabolites in fish muscle tissue by stable isotope dilution ultra-performance liquid chromatography tandem mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2011, 2: 727-734.
[87] De la Cruz Marcia N. S., Soares Renata F., Marques Anna Sylvia F., et al. Development and Validation of Analytical Method for Sulfonamide Residues in Eggs by Liquid Chromatography Tandem Mass Spectrometry based on the Comission Decision 2002/657/EC[J]. Journal of the Brazilian Chemical Society, 2011, 3: 454-461.
[88] Martos Perry A., Lehotay Steven J., Shurmer Bryn, et al. Ultratrace analysis ofnine macrolides, including tulathromycin A (Draxxin), in edible animal tissues with minicolumn liquid chromatography tandem mass spectrometry[J]. Journal of Agricultural and Food Chemistry, 2008 , 19: 8844-8850.
[89] Cronly Mark, Behan Patrice, Foley Barry, et al. Survey of 11 nitroimidazole residues in hen and duck eggs from the Irish market[J]. Food Additives& Contaminants Part B-surveillance, 2011, 2: 79-87.
[90] Bilandzic Nina, Kolanovic Bozica Solomun, Varenina Ivana, et al. Veterinary drug residues determination in raw milk in Croatia[J]. Food Control, 2011, 12: 1941-1948.
[91] Lee Jung-Bin, Back Yu-Mi, Her Jae-Young, et al. AGFD 127-Analysis of sulfonamide and quinolone antibiotic residues in milk using microbial assays and high performance liquid chromatography (HPLC) [J]. Abstracts of Papers of the American Chemical Society, 2007, 234: 127-AGFD.
[92] Chitescu C. L., Nicolau A. I., Csuma A., et al. Simultaneous analysis of four sulfonamides in chicken muscle tissue by HPLC[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure& Risk Assessment, 2011, 8: 1013-1020.
[93] Won So Young, Lee Chang Hee, Chang Hye Sook, et al. Monitoring of 14 sulfonamide antibiotic residues in marine products using HPLC-PDA and LC-MS/MS[J]. Food Control, 2011, 7: 1101-1107.
[94] Bialk-Bielinska Anna, Siedlewicz Grzegorz, Stepnowski Piotr, et al. A very fast and simple method for the determination of sulfonamide residues in seawaters[J]. Analytical Methods, 2011, 6: 1371-1378.
[95] Jesus Garcia-Galan M., Silvia Diaz-Cruz M., Barcelo Damia. Occurrence of sulfonamide residues along the Ebro river basin Removal in wastewater treatment plants and environmental impact assessment[J]. Environment International, 2011, 2: 462-473.
[96] Kowalski Piotr, Plenis Alina, Oledzka Ilona, et al. Optimization and validation of the micellar electrokinetic capillary chromatographic method for simultaneous determination of sulfonamide and amphenicol-type drugs inpoultry tissue[J]. Journal of Pharmaceutical and Biomedical Analysis, 2011, 1: 160-167.
[97] Roudaut B, Garnier M. Sulphonamide residues in eggs following drug administration via the drinking water[J]. Food Additives and Contaminants, 2002, 4: 373-378.
[98] Perret D, Gentili A, Marchese S, et al. Sulphonamide residues in Italian surface and drinking waters: A small scale reconnaissance[J]. Chromatographia, 2006, 5-6: 225-232.
[99] Roudaut B, Moretain J P. Sulphonamide residues in milk of dairy cows following intravenous injection[J]. Food Additives and Contaminants , 1990, 4: 527-533.
[100] Finlay E M, Games D E, Startin J R, et al. Screening, confirmation, and quantification of sulphonamide residues in pig kidney by tandem mass spectrometry of crude extracts[J]. Biomedical & Environmental Mass Spectrometry, 1986, 11: 633-639.
[101] Herrera-Herrera Antonio V., Hernandez-Borges Javier, Angel Rodriguez-Delgado Miguel. Fluoroquinolone antibiotic determination in bovine, ovine and caprine milk using solid-phase extraction and high-performance liquid chromatography-fluorescence detection with ionic liquids as mobile phase additives[J]. Jounal of Chromatography A, 2009, 43: 7281-7287.
[102] Schneider MJ. Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using automated microdialysis-liquid chromatography[J].Journal of Chromatographic Science, 2011, 8: 351-356.
[103] Choi J, Yee AJ, Thompson D, et al. Determination of fluoroquinolone residues in animal tissues using Escherichia coli as indicator organism[J]. Journal of Aoac International, 1999, 6: 1407-1412.
[104] Beeton Michael L., Chalker Victoria J., Kotecha Sailesh, et al. Comparison of full gyrA, gyrB, parC and parE gene sequences between all Ureaplasma parvum and Ureaplasma urealyticum serovars to separate true fluoroquinoloneantibiotic resistance mutations from non-resistance polymorphism[J]. Journal of Antimicrobial Chemotherapy, 2009, 3: 529-538.
[105] Ashwin Helen, Stead Sara, Caldow Marianne, et al. A rapid microbial inhibition-based screening strategy for fluoroquinolone and quinolone residues in foods of animal origin[J]. Analytica Chimica Acta, 2009 , 1-2: 241-246.
[106] Mohan J, Sastry KVH, Tyagi JS, et al. Residues of fluoroquinolone drugs in the cloacal gland and other tissues of Japanese quail[J]. British Poultry Science, 2006, 1: 83-87.
[107] Fernandez Fatima, Pinacho Daniel G., Sanchez-Baeza Francisco, et al. Portable Surface Plasmon Resonance Immunosensor for the Detection of Fluoroquinolone Antibiotic Residues in Milk[J]. Journal of Agricultural and Food Chemistry, 2011, 9: 5036-5043.
[108] Kanda Maki, Kusano Tomoto, Kanai Setsuko, et al. Rapid Determination of Fluoroquinolone Residues in Honey by a Microbiological Screening Method and Liquid Chromatography[J]. Journal of Aoac International, 2010, 4, 1331-1339.
[109] Schneider MJ, Donoghue DJ. Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using liquid chromatography-fluorescence-multiple mass spectrometry[J]. Journal of Chromatography B-analytical Technologies in the Biomedical and Life Sciences, 2002, 1: 83-92.
[110] Tang Qingfa, Yang Tongtong, Tan Xiaomei, et al .Simultaneous Determination of Fluoroquinolone Antibiotic Residues in Milk Sample by Solid-Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometry[J]. Journal of Agricultural and Food Chemistry, 2009, 11: 4535-4539.
[111] Tang Qingfa, Yang Tongtong, Tan Xiaomei, et al. Simultaneous Determination of Fluoroquinolone Antibiotic Residues in Milk Sample by Solid-Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometr[J]. Journal of Agricultural and Food Chemistry, 2009, 11: 4535-4539.
[112] McMullen Sarah E., Schenck Frank J., Vega Victor A. Rapid Method for the Determination and Confirmation of Fluoroquinolone Residues in Catfish Using Liquid Chromatography/Fluorescence Detection and Liquid Chromatography-Tandem Mass Spectrometry[J]. Journal of aoac international, 2009, 4: 1233-1240.
[113] Guo Wei, Liu Yong, Liu Ning. Simultaneous analysis of 7 fluoroquinolone residues in chicken muscle by ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2009, 4: 406-411.
[114] Adrian Javier, Pasche Stephanie, Pinacho Daniel G., et al. Wavelength-interrogated optical biosensor for multi-analyte screening of sulfonamide, fluoroquinolone, beta-lactam and tetracycline antibiotics in milk[J]. Trac-trends in Analytical Chemistry, 2009, 6: 769-777.
[115] Guo Genhe, Pan Wei, Su Desen, et al. Simultaneous determination of four fluoroquinolone residues in fish by ion-pair high performance liquid chromatography[J].Chinese Journal of Chromatography, 2005, 4: 401-403.
[116] Choi Jeong Heui, El-Aty A. M. Abd, Shen Jing Yu, et al. Analysis of fluoroquinolone residues in edible chicken tissues using supercritical fluid extraction[J]. Berliner Und Munchener Tierarztliche Wochenschrift, 2006,11-12: 456-460.
[117] Cronly M., Behan P., Foley B., et al. Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS) [J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 2010, 9: 1233-1246.
[118] Wang Yabin, He Fangyang,Wan Yuping,et al. Indirect competitive enzyme-linked immuno-sorbent assay (ELISA) for nitroimidazoles in food products[J]. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 2011, 5: 619-626.
[119] Capitan-Vallvey LF, Ariza A, Checa R, et al. Determination of fivenitroimidazoles in water by liquid chromatography-mass spectrometry[J]. Journal of Chromatography A, 2002, 1-2: 243-248.
[120] Gui Yi, Ni Yong Nian, Kokot Serge. Simultaneous determination of three 5-nitroimidazoles in foodstuffs by differential pulse voltammetry and chemometrics[J]. Chinese Chemical Letters, 2011, 5: 591-594.
[121] Cronly Mark, Behan Patrice,Foley Barry, et al. Development and validation of a rapid method for the determination and confirmation of 10 nitroimidazoles in animal plasma using liquid chromatography tandem mass spectrometry[J]. Journal of Chromatography B-analytical Technologies in the Biomedical and Life Sciences, 2009, 14-15: 1494-1500.
[122] Hack T, Georgi K, Speer K. Confirmatory method for the verification of Nitroimidazoles in eggs[J]. Deutsche Lebensmittel-rundschau, 2003, 6: 231-235.
[123] Wang Hai, Wang Zijian, Liu SuYing, et al. Quantification of Nitroimidazoles Residues in Swine Liver by Liquid Chromatography-Mass Spectrometry with Atmospheric Pressure Chemical Ionization[J]. Bulletin of Environmental Contamination and Toxicology, 2009, 4: 411-414.
[124] Shen JZ, Yhang Y, Zhang SX, et al. Determination of nitroimidazoles and their metabolites in swine tissues by liquid chromatography[J]. Journal of Aoac international, 2003,3: 505-509.
[125] Huet AC, Mortier L, Daeseleire E, et al. Development of an ELISA screening test for nitroimidazoles in egg and chicken muscle[J]. Analytica Chimica Acta, 2005, 1: 157-162.
[126] Hurtaud-Pessel D, Delepine B, Laurentie M. Determination of four nitroimidazole residues in poultry meat by liquid chromatography-mass spectrometry[J]. Journal of Chromatography A, 2000, 1-2: 89-98.
[127] Xia Xi, Li Xiaowei, Shen Jianzhong, et al. Determination of nitroimidazole residues in porcine urine by liquid chromatography/tandem mass spectrometry[J]. Journal of aoac international, 2006, 4: 1116-1119.
[128] Semeniuk S, Posyniak A, Niedzielska J, et al. Determination of nitroimidazoleresidues in poultry tissues, serum and eggs by high-performance liquid chromatography[J]. Biomedical Chromatography, 1995, 5: 238-42.
[129]潘媛媛,史亚利,蔡亚岐.高效液相色谱-串联质谱技术分析人血液中的全氟化合物.第五届全国环境化学大会, 2009, 408.
[130]金明. UPLC-MS/MS测定牛肝中七种磺胺类药物的研究.甘肃农业大学硕士毕业论文, 2008.
[131]崔海滨,刘晓丽,徐榕蔓等.超高效液相色谱-串联质谱技术检测番茄制品中矮壮素及缩节胺残留量的方法研究[J].福建分析测试, 2009, 18: 20-24.
[132]张瑾.动物性食品中兽药残留的原因、危害及控制对策[J].吉林畜牧兽医,2009,30:1-7.
[133]沈建忠.动物性食品中兽药残留与检测.农民日报, 2004, (11月3日,第6版)
[134]陈杖榴,曾振灵.对我国动物源性食品中兽药残留问题的思考[J].中国动物保健, 2003, 12: 8-12.
[135]王少敏,邹大鹏,张建业等.高效液相色谱/串联质谱法快速鉴定Z / E盐酸头孢吡肟异构体[J].分析化学研究简报, 2006, 34: 1278-1282.
[136]张丽军,姚亚敏,孙建军等.高效液相色谱-串联质谱法同时测定奈韦拉平、拉米夫定、司他夫定、齐多夫定和依非韦伦的血药浓度[J].中国临床药理学杂志, 2010, 26: 133-136.
[137]孙俊杰.高效液相色谱-质谱联用在药物分析中的应用.中国科学技术大学硕士学位论文, 2010.
[138]王俊菊,高木珍,包建民.高效液相色谱串联质谱技术在兽药残留检测中的应用进展[J].中国兽药杂志, 2011, 45: 45-51.
[139]罗亚男.高效液相色谱串联质谱技术在药物分析中的应用.中国科学技术大学硕士学位论文, 2011.
[140]张宪忠,孙红文,汪磊等.固相萃取高效液相色谱串联质谱技术测定污水中的全氟化合物[J].环境化学, 2009, 28: 944-945.
[141]杨秋红,钱蜀,程小艳等.固相萃取地表水中痕量联苯胺及HPLC-MS测定[J].化学研究与应用, 2011, 23: 102-106.
[142]吕桂霞,刁有祥,许胜勇.建立完善的兽药残留监控体系势在必行[J].中国兽药杂志, 2002, 36: 7-9.
[143]刘佳佳,佘永新,刘洪斌等.聚醚类抗生素残留检测技术及其研究进展[J].食品工业科技, 2011, 32: 440-444.
[144]余华,严玉宝,谢晶等.酶联免疫分析技术及其在进出口动物产品兽药残留检测中的应用[J].中国畜牧兽医, 2010, 37: 76-79.
[145]郝贵增,龙淼.肉类食品中兽药残留快速检测研究进展[J].肉类研究, 2008, 6: 64-66.
[146]刘丹.生物样品中阿德福韦等4种药物的LC/MS/MS测定方法的研究及应用.沈阳药科大学博士学问论文, 2006.
[147]董义春.食品安全与兽药残留监控[J].中国兽药杂志,2009,43: 24-28.
[148]魏红波,李崇瑛,闫海全.食品中抗生素类兽药残留的分析方法[J].粮食与饲料工业, 2008, 4: 42-44.
[149]陆辉,郑义,卢军锋.兽药残留的危害及对策[J].泰州职业技术学院学报, 2008, 8: 75-78.
[150]杨成对,宋莉晖.双酚A残留的检测方法研究[J].食品科学, 2008, 29: 316-317.
[151]栾晓蕊,张婷,吴霞等.利用液相色谱串联质谱技术检测卵巢上皮性癌血清标记物的研究[J].现代妇产科进展, 2010, 19: 510-513.
[152]龚炜.烟草中农药残留的液相色谱一串联质谱分析方法研究.郑州大学硕士学位论文, 2007.
[153]杨方,庞国芳,刘正才等.液相色谱-串联质谱法检测水产品中15种喹诺酮类药物残留量[J].分析实验室, 2008, 27: 27-33.
[154]毛友安,钟科军,魏万之等.液相色谱-串联质谱技术测定卷烟烟气中烟草特有亚硝胺[J].现代科学仪器, 2006, 1: 88-90.
[155]谢萍.液相色谱--串联质谱技术用于塑料包装材料中增塑剂迁移检测的研究.吉林大学博士学位论文, 2008.
[156]聂芳红,徐晓彬,陈进军.食品动物兽药残留的研究进展[J].中国农学通报, 2006, 22: 71-75.
[157]孙雷,刘琪,王树槐.液相色谱--串联质谱技术进展及在兽药行业上的应用[J].中国兽药杂志, 2007, 41:34-37.
[158]胡万群,许毓,刘飞等.液质联用检测人体血浆中的阿奇霉素[J].高等学校化学学报, 2007, 28: 2046-2050.
[159]孟芳.液相色谱--串联质谱法定量分析血浆中四种抗生素药物研究.沈阳药科大学硕士学位论文, 2005.
[161]马洪宝.兽药残留对动物性食品安全的影响[J].中国动物检疫, 2007, 2: 21-22.
[162]丁晓刚,赵劲航,卫澜欣,等.兽药残留对人类健康的危害[J].中国动物保健, 2007, 02: 67-68.
[163]岳振峰,林秀云,唐少冰,等.高效液相色谱-串联质谱法测定动物组织中的16种喹诺酮类药物残留[J].色谱, 2007, 25(4): 491-495.
[164]岳振峰,谢丽琪,陈小霞,等.牛奶中16种喹诺酮类药物残留量的高效液相色谱-串联质谱法测定[J].分析测试学报, 2008, 27(3): 240-243.
[165]李爱军,王明泰,牟峻,等.食品中野燕枯残留量的测定[J].农药, 2006, 45(12): 842-845.
[166]卢利军,周晓,韩大川,等.液相色谱串联质谱法测定纺织品和皮革中PFOS含量[J].印染助剂, 2009, 26(10): 50-53.
[167]谢萍,宋慧,刘英杰,等.液相色谱串联质谱法研究小刺猴头菌子实体中污染物增塑剂[J].高等学校化学学报, 2007, 28(11): 2040-2045.
[168]王明泰,牟峻,吴剑等.GC-MS法测定粮谷及油料中55种有机磷农药残留量[J].分析实验室,2006,25(11):110-117.
[169]王明泰,牟峻,靳颖等.GPC净化处理在测定拟除虫菊酯残留量中的应用[J].印染,2007,(6):37-40.
[170]甘宾宾,汤艳荣,蒋世琼.高效液相色谱--质谱联用技术在食品安全中的应用及进展[J].化工技术与开发, 2009, 38(12):33-37.
[171]唐林林.蜂群用药对蜂蜜中药物残留影响的研究[硕士学位论文].福建:福建农林大学,2008.
[172]王明泰,牟峻,靳颖等.纺织品有机氮农药残留量的LC MS/MS测定法[J].印染,2007,(8):31-35.
[173]王建华.食品中农药残留和常见重点有机污染物检测技术的研究和应用[博士研究生学位论文].中国海洋大学,2007.
[174]陈宝明.浅谈兽药残留的种类及危害.北方牧业,2003.12.30.
[175]李爱军,王明泰,牟峻等.气相色谱--质谱联用法测定水果中四螨嗪残留量[J].理化检验(化学分册),2008, 44: 323-325.
[176]陈敏艳,孙涛,王香敏.兽药残留及其危害[J].动物医学进展,2005,26(10):111-113.
[177]姜力,文学忠,钟雯.兽药残留与食品安全[J].吉林畜牧兽医,2011,32(5):1-9.
[178]李爱军,王明泰,牟峻等.植物源性饲料中燕麦枯残留量的测定[J].粮食与饲料工业,2008,(6):42-44.
[179]谢萍.液相色谱--串联质谱技术用于塑料包装材料中增塑剂迁移检测的研究[博士研究生学位论文].长春:吉林大学,2008.
[180]王志元,张思群,席静等.水果及果汁中二恶英类似物三氯新残留量的超高效液相色谱--串联质谱检测方法研究[J].中国卫生检验杂志,2011,21(6):1325-1327.
[181]王明泰,牟峻,吴剑等.蔬菜及水果中77种有机磷和氨基甲酸酯农药残留量检测技术研究[J].食品科学,2007,28(3):247-253.
[182]郭德华,邓晓军,赵善贞等.固相萃取--高效液相色谱/串联质谱同时检测动物源性食品中76种兽药残留[J].分析化学研究报告,2010, 38(3):318-324.
[183]曹军,陈勇,杨瑞章等.分散固相萃取--高效液相色谱--串联质谱法测定水产品中19种喹诺酮类兽药残留[J].中国兽药杂志,2011,45(7):21-25.
[184]石威.不同生长期人参中化学成分及农药残留的研究[博士研究生学位论文].长春:吉林大学,2007.
[185]王钟.气相色谱--质谱法测定蔬菜中有机磷农药和氨基甲酸脂类农药残留的研究[研究生学位论文].济南:山东大学,2010.
[186]丁力.有机污染物的色谱-质谱联用检测新方法研究与应用[研究生学位论文].衡阳:南华大学,2008.
[187]李春风,岳振峰,赵凤娟等.液相色谱串联质谱测定水产品中吩噻嗪类药物残留的研究[J].中国兽医学报,2010,30(3):384-387.
[188]董丹.液相色谱-质谱/质谱测定动物源性食品和水中17种磺胺[硕士学位论文].沈阳:东北大学,2004.
[189]王翔,邓晓军,宋国新等.食品中磺胺类兽药残留前处理技术的研究进展[J].食品科学,2009,30(7):254-257.Yuan ZH. Chinese regulations on veterinary drug residues. 5th Congress of Toxicology in Developing Countries, 2003, 1: 26-27.
[190] Pecorelli I, Bibi R, Fioroni L, et al. Validation of a confirmatory method for the determination of sulphonamides in muscle according to the European Union regulation 2002/657/EC. 27th International Symposium on High-Performance Liquid-Phase Separations and Related Techniques, 2004, 1-2: 23-29.
[191] Kaufmann A., Butcher P., Maden K., et al. Development of an improved high resolution mass spectrometry based multi-residue method for veterinary drugs in various food matrices. 6th International Symposium on Hormone and Veterinary Drug Residue Analysis (VRDA), 2011, 1-2: 86-94.
[192] Kan CA, Petz M. Residues of veterinary drugs in eggs and their distribution between yolk and white. Symposium on Agrochemical Residues in Eggs held during the Fall 1999 National Meeting of the American-Chemical-Society, 2000, 12: 6397-6403.
[193] Reig Milagro, Toldra Fidel. Veterinary drug residues in meat: Concerns and rapid methods for detection, 2008, 1-2: 60-67.
[194] Munoz P, Blanca J, Ramos A, et al. A versatile liquid chromatography-tandem mass spectrometry system for the analysis of different groups of veterinary drugs. 5th Euroresidue Conference, 2005, 1-2: 137-144.
[195] Stubbings George, Bigwood Timothy. The development and validation of a multiclass liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure for the determination of veterinary drug residues in animal tissue using a QuEChERS (QUick, Easy, CHeap, Effective, Rugged and Safe) approach. EuroResidue VI Conference, 2009, 1-2: 68-78.
[196] Xia X., Li X., Zhang S, et al. Confirmation of four nitroimidazoles in porcine liver by liquid chromatography-tandem mass spectrometry. 5th International Symposium on Hormone and Veterinary Drug Residue Analysis, 2007, 1-2:394-398.
[197] Scherpenisse Peter, Bergwerff Aldert A. Determination of residues of tricaine in fish using liquid chromatography tandem mass spectrometry. 5th International Symposium on Hormone and Veterinary Drug Residue Analysis, 2007, 1-2: 407-410.
[198] Pena A, Silva L. J. G., Pereira A, et al. Determination of fluoroquinolone residues in poultry muscle in Portugal. 6th International Conference on Instrumental Methods of Analysis, 2010, 6: 2615-2621.
[199] Posyniak A, Zmudzki J, Semeniuk S. Effects of the matrix and sample preparation on the determination of fluoroquinolone residues in animal tissues. 24th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2000), 2001, 1-2: 89-94.
[200] Oliver L. K., Bigwood T., Stubbings G.. Multiresidue analysis of nitroimidazoles, benzimidazoles and levamisole in food of animal origin. 55th Annual Conference on Current Topics in Veterinary Science, 2001, Supplement A:46.