摘要
目的:评估超微化白芨粉栓塞剂治疗原发性肝癌(primary hepitia cancer, PHC)的临床价值,为临床应用超微化白芨粉栓塞剂提供可靠的依据。方法:66例原发性肝癌患者随机分成两组,实验组:36例,超微化白芨粉、羟基喜树碱、超液态碘化油(又称乙碘油)混悬液栓塞肿瘤供血动脉; 对照组:30例,乙碘油、羟基喜树碱栓塞肿瘤供血动脉。所有患者均在DSA下行肝动脉栓塞灌注化疗术(TACE)。观察两组术后肿瘤缩小率、近期疗效、毒副反应和生存状况(术后3、6、12、24个月生存率)。结果:实验组栓塞治疗后, 3、6、12个月肿瘤缩小率分别为36.1±2.3%,55 .5±4.5% ,72.2±3.4%,高于对照组; 实验组术后3、6、12、24个月生存率分别为97.2 %、91.6%、80.5%、44.4%,平均生存期为18.8±4.1月; 对照组患者术后3、6、12、24个月生存率分别为93.3%、86.8%、66.6%、23.3%,平均生存期为15±5.3月,两组比较(P值<0.05)有显著差异。两组毒副反应无显著差异。结论:超微化白芨粉栓塞剂治疗原发性肝癌,介入治疗栓塞后肿瘤转移、复发率低,可明显提高介入治疗的疗效和肝癌患者的远期生存率。
Objective: To observe the clinical effects of supermicro-bletilla striata powder mixture on the embolization of primary hepatocellular carcinoma. Method: 66cases with PHC were randomly divided into two groups: Test group and control group.Test group included 36 cases treated with mixture of supermicro-bletilla striata powder plus hydroxyl camptothecinum and iodine oil, control group included 30 cases with hydroxyl camptothecinum and iodine oil .all the patients were operated with TACE under DSA. To observe the decreased ratio of tumour, recent effects, toxication and side effects and survival condition(postoperative survival rate in 3,6,12 and 24month, respectively). Results: Decreased rat of tumor in test group were 36.1±2.3%,55.5±4.5% and 72.2±3.4% after 3, 6,and12 month respectively, distinguished with that in control group. Postoperative survival rate of test group were 97.2 % 、91.6%、80.5% and 44.4% in 3,6,12,and 24 month respectively,remarkably different from that of control group. The side effects and toxications of two groups were no difference. Conclusion: Supermicro –bletilla striata powder mixture as embolism reagent used in TACE could reduced the reccurence and transfusion of tumor, remarkeably increase the survival rate.
引文
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