水稻蛋白磷酸酶2C基因OsBIPP2C1和OsBIPP2C2的克隆鉴定与功能分析
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摘要
我们实验室在前期研究中，以苯并噻二唑(BTH)诱导水稻抗病性，用抑制性差减杂交法分离鉴定了200多个差异表达的cDNA。基因数据库同源性搜索分析表明，其中差别表达克隆HIBI-n9和BIHI-w2与已知植物蛋白磷酸酶2C(PP2C)基因具有较高的同源性，推测这两个克隆很可能编码水稻PP2C基因的部分序列。为明确这两个可能的水稻磷酸酶基因的生物学功能以及在水稻抗病性中的作用，本研究通过5’RACE和3’RACE，结合电子克隆的方法，分离到这两个水稻磷酸酶基因的全长cDNA序列，分别命名为OsBIPP2C1和OsBIPP2C2。
采用电子克隆的方法，首先在EST数据库搜索与BIHI-w2相匹配的水稻EST，并拼接成一条长的序列。根据拼接序列设计基因特异引物，从水稻cDNA文库中用PCR扩增到1900 bp的序列。测序表明，该序列含有一个1710 bp的开放阅读框(ORF)，编码的蛋白有569 aa，分子量58.7kD，等电点为4.1。预测该蛋白的前38 aa是可剪切的信号肽。序列分析表明，OsBIPP2C1蛋白含有一个蛋白磷酸酶2C的结构域，结构域中与PP2C活性相关的与金属离子结合的碱基也大多保守。该蛋白序列与拟南芥ABI2、烟草NtPP2C1、苜蓿MP2C、拟南芥AtPP2CA等蛋白分别有14.4％、16.3％、15.0％和13.3％的相似性。因此，这是一个新的PP2C基因，命名为水稻BTH诱导的PP2C 1(Oryza sativa L.BTH induced proteinphosphatase 2C 1,OsBIPP2C1)。进一步分析发现，OsBIPP2C1以单拷贝的形式存在于水稻BAC克隆OSJNBb0019D17(登录号AC116604)中，其位点在染色体22.1cM处。在距该基因12 kb处，有一个已经报道过的肌醇-3-磷酸合成酶基因(登录号AB012107)。
用0.3 mmol／L BTH悬浮液喷雾处理水稻后6 h后OsBIPP2C1即受到快速激发，相对较高的水平维持至24 h，至72 h才逐渐降低到处理前的水平。喷雾清水的对照处理仅有微量的表达，在处理时间段没有明显波动。用BTH喷雾预处理3
浙江大学博士学位论文
d后接种稻瘟病菌(MagnaPorthe grisea)的水稻中，‘七刀万护Zc]基因在接种后6
h受到低量诱导表达，至处理后48h开始，该基因的表达骤增。仅用稻瘟病接种
处理的水稻幼苗中，OsB厅)P ZCI有一定本底表达但不受稻瘟菌接种的诱导。用1
mmo比水杨酸(SA)处理水稻时，乙坛刀万护ZC]基因表达不受影响，但srnnlol/L
HZO:处理后12h则受到诱导。表明在抗病信号途径中乙枯召护尸ZCI基因位于SA
上游但处于HZO:信号途径的下游。口‘刀井沪ZC了同时还能被盐、重金属、冷害、
干旱和ABA诱导，表明该基因在逆境信号传递中的普遍角色。
将乙七刀万沪2CI基因连接到转基因载体CHF3的CaMV一355启动子下游，转化
烟草，得到13株转基因株系。PCR扩增检测口招仔孕2CI基因都整合到烟草基因
组中，Northem杂交能检测到大部分株系乙七刀护尸2CI的表达，并组成型表达烟草
PR了基因。转‘枯丑刀￥Ucl基因Tl代增强了烟草对TMv和烟草黑胫病护句夕toPhthora
Parasitic。var. nicotiana。)的抗性。不同转基因株系在4林mol/L ABA处理下的种子
萌发率和株高有较大差异。但强表达的转基因株系对高盐(200~。FL NaCI)和
低渗透压(400~。比甘露醇)处理的适应性更强。表明OsB万沪2CI基因与抗
病性和抗逆性相关。
用类似的方法克隆到另外一个PPZC蛋白基因口‘召万沪2口，即水稻受BTH诱
导的蛋白磷酸酶2C2但下“-互口tiva L.罗H加dueed梦otein妙osphatase丝2，
OsBIPPZC2)。乙坛丑厅￥UCZ有两个大小不同的转录本，乙坛丑瑟沪2口一K2(简写作K2)
和OsB万沪2C2一K3(简写作K3)。分析认为，两转录本是由于较大的转录第3个
外显子有一个较弱的GT一AG剪接位点，剪接后形成较小的转录本。两个选择性
剪接本差异103bP，因而读码框发生移码，较小转录本提前中止翻译。K2和娜
O盯大小分别为114obp和765bp，编码的蛋白分别为38oaa和255aa，分子量
41.8kD和27.8kD，等电点分别是9.37和8.88。这两个蛋白在大肠杆菌中得到表达，
并得到纯化的蛋白。K2和K3均含有维持PPZC酶活性的保守位点，但K3缺少
第262位的AsP。K2与一个来自欧洲样(凡g“:sylvatica)的FsPPZcZ有50%核
酸和67%的碱基相似性。
乙坛刀万沪2C2的表达模式与乙枯刀万沪2CI有些类似但存在一定差异。首先，受
BTH处理的时候，其表达比OsB仔沪2CI
预处理3d再接种稻瘟菌后，乙七刀护尸2口
更快，在24h即达到最高峰。其次，BTH
激发的速度比乙七丑序沪ZCj稍慢，但是强
浙江大学博士学位论文
度更高。第三，在与供试稻瘟菌分别表现亲和不亲和互作的水稻近等基因系HSR
和HSS中，非亲和品系HSR接种稻瘟菌后12h可见OsBIPPZCZ的诱导表达，而
在亲和品系HSS接种稻瘟菌对乙七刀刀邓心口没有明显的诱导。这些结果表明，
OsB万)P 2C2可能与水稻抗病相关。实验证明，水稻口‘刀护尸2口基因受到ABA诱
导表达;低温、千旱、创伤、重金属盐、高盐等各种逆境因子的诱导。为判别在
两个转录本中那一个对水稻的抗病和逆境适应中起作用，我们进行了RT一PCR。
结果表明，绝大多数的时候，只检测到心转录本。而幻转录本在伤口反应中可
能有极微量表达。
In the previous work of our lab, over 200 differential expressed cDNA from rice induced by benzothiadiazole (BTH) were cloned and identified through suppression subtractive hybridization. Among them, HIBI-n9 and BIHI-w2 with inserts of 414 bp and 755 bp, respectively, showed significant similarities to genes encoding known plant phosphatase 2C proteins. In order to elucidate the biological function of these two putative phosphatase 2C genes and their role in rice disease resistance, this study cloned and identified full-length cDNA of the genes and designated as OsBIPP2Cl and OsBIPP2C2, respectively.
The full-length cDNA of OsBIPP2Cl was isolated through a combination of virtual cloning and RACE. Rice ESTs matching to BIHI-w2 sequence were retrieved from dbEST of GenBank database and a single long sequence was assembled. The assembled sequence is of 1900 bp long and contains an open reading frame (ORF) of 1710 bp, which predicts to encode a protein of 569 amino acids with a calculated molecular weight of 58.7 kD and the isolectric point of 4.1. A signal peptide is predicted to locate from the first amino acid to the 39th amino acid at the N-terminus of the OsBIPP2Cl protein. The predicted protein sequence contains a protein phosphatase 2C domain, approximately 255 aa in length at its C terminus. In this domain, most of the amino acids that are required for binding Mg2+/Mn2+ ions to maintain catalytic activity were identified. The OsBEPP2Cl shares weak sequence identity to other PP2Cs identified so far, showing 13-16% of identity to Arabidopsis ABI2 and AtPP2CA, tobacco NtPP2Cl and Medicago MP2C. So it is
a new protein, we called it OsBEPP2Cl (Oryza_sativa L. BTHjnduced p_rotein phosphatase 2C 1, OsBIPP2Cl). The OsBIPP2Cl gene exists as single copy on the rice chromosome 3. As there is no phosphatase 2C gene identified in rice so far, we therefore concluded that OsBIPP2Cl is a novel gene encoding phosphatase 2C in rice.
OsBIPP2Cl was rapidly activated as soon as 6 hr after treatment by spraying with 0.3 mM BTH solution, maintained a relatively high level within 24 hr, and thereafter
declined gradually to the normal level at 72 hr after treatment. Inducible expression of OsBIPP2Cl was detected as early as 6 hr in BTH-treated rice seedlings after inoculation with the blast fungus, Magnaporthe grisea. This inducible expression was maintained at a relatively low level within the first 24 hr after inoculation. The significant induction was observed during the second 24 hr and then declined to normal level. In contrast, no obvious fluctuation of OsBIPP2Cl gene expression was detected in water-treated rice seedlings after inoculation. Meanwhile, OsBIPP2Cl was only slightly up-regulated by treatment with SA, but was strongly induced by 5 mM H2O2 within 12 hr after treatment. Moreover, OsBIPP2Cl was also found to be induced by salts, heavy metals and ABA, implying its multiple roles in stress acclimation. This is a common characteristic of some other stress-responsive PP2Cs such as ABI1 and ABE.
Coding sequence of OsBIPP2Cl was cloned to downstream of CaMV-35S promoter in the plant binary vector CHF3. Constructed vector was transformed into tobacco by Agrobacterium-mediated leaf disc transformation. A total of 13 transgenic lines were obtained through screening of antibiotic resistant re-generating seedlings and PCR detection. Northern blotting analysis showed that OsBIPP2Cl was expressed in most of the transgenic lines. Preliminary results showed the Tl plants of the OsBIPP2Cl-overexpressing lines enhanced the resistance to tobacco mosaic virus (TMV) and tobacco blank shank (Phytophthora parasitica var. nicotianae) diseases. Moreover, the transgenic Tl plants also showed an enhanced tolerance to salt and osmotic stress. The Tl generation of the transgenic lines showed a variable sensitivity to ABA as illustrated by germination rate of the seeds and seedling growth under ABA treatments.
Another PP2C gene was cloned by a similar way to that used in isolation of OsBIPP2Cl and was named as OsBIPP2C2 (Oryza
采用电子克隆的方法，首先在EST数据库搜索与BIHI-w2相匹配的水稻EST，并拼接成一条长的序列。根据拼接序列设计基因特异引物，从水稻cDNA文库中用PCR扩增到1900 bp的序列。测序表明，该序列含有一个1710 bp的开放阅读框(ORF)，编码的蛋白有569 aa，分子量58.7kD，等电点为4.1。预测该蛋白的前38 aa是可剪切的信号肽。序列分析表明，OsBIPP2C1蛋白含有一个蛋白磷酸酶2C的结构域，结构域中与PP2C活性相关的与金属离子结合的碱基也大多保守。该蛋白序列与拟南芥ABI2、烟草NtPP2C1、苜蓿MP2C、拟南芥AtPP2CA等蛋白分别有14.4％、16.3％、15.0％和13.3％的相似性。因此，这是一个新的PP2C基因，命名为水稻BTH诱导的PP2C 1(Oryza sativa L.BTH induced proteinphosphatase 2C 1,OsBIPP2C1)。进一步分析发现，OsBIPP2C1以单拷贝的形式存在于水稻BAC克隆OSJNBb0019D17(登录号AC116604)中，其位点在染色体22.1cM处。在距该基因12 kb处，有一个已经报道过的肌醇-3-磷酸合成酶基因(登录号AB012107)。
用0.3 mmol／L BTH悬浮液喷雾处理水稻后6 h后OsBIPP2C1即受到快速激发，相对较高的水平维持至24 h，至72 h才逐渐降低到处理前的水平。喷雾清水的对照处理仅有微量的表达，在处理时间段没有明显波动。用BTH喷雾预处理3
浙江大学博士学位论文
d后接种稻瘟病菌(MagnaPorthe grisea)的水稻中，‘七刀万护Zc]基因在接种后6
h受到低量诱导表达，至处理后48h开始，该基因的表达骤增。仅用稻瘟病接种
处理的水稻幼苗中，OsB厅)P ZCI有一定本底表达但不受稻瘟菌接种的诱导。用1
mmo比水杨酸(SA)处理水稻时，乙坛刀万护ZC]基因表达不受影响，但srnnlol/L
HZO:处理后12h则受到诱导。表明在抗病信号途径中乙枯召护尸ZCI基因位于SA
上游但处于HZO:信号途径的下游。口‘刀井沪ZC了同时还能被盐、重金属、冷害、
干旱和ABA诱导，表明该基因在逆境信号传递中的普遍角色。
将乙七刀万沪2CI基因连接到转基因载体CHF3的CaMV一355启动子下游，转化
烟草，得到13株转基因株系。PCR扩增检测口招仔孕2CI基因都整合到烟草基因
组中，Northem杂交能检测到大部分株系乙七刀护尸2CI的表达，并组成型表达烟草
PR了基因。转‘枯丑刀￥Ucl基因Tl代增强了烟草对TMv和烟草黑胫病护句夕toPhthora
Parasitic。var. nicotiana。)的抗性。不同转基因株系在4林mol/L ABA处理下的种子
萌发率和株高有较大差异。但强表达的转基因株系对高盐(200~。FL NaCI)和
低渗透压(400~。比甘露醇)处理的适应性更强。表明OsB万沪2CI基因与抗
病性和抗逆性相关。
用类似的方法克隆到另外一个PPZC蛋白基因口‘召万沪2口，即水稻受BTH诱
导的蛋白磷酸酶2C2但下“-互口tiva L.罗H加dueed梦otein妙osphatase丝2，
OsBIPPZC2)。乙坛丑厅￥UCZ有两个大小不同的转录本，乙坛丑瑟沪2口一K2(简写作K2)
和OsB万沪2C2一K3(简写作K3)。分析认为，两转录本是由于较大的转录第3个
外显子有一个较弱的GT一AG剪接位点，剪接后形成较小的转录本。两个选择性
剪接本差异103bP，因而读码框发生移码，较小转录本提前中止翻译。K2和娜
O盯大小分别为114obp和765bp，编码的蛋白分别为38oaa和255aa，分子量
41.8kD和27.8kD，等电点分别是9.37和8.88。这两个蛋白在大肠杆菌中得到表达，
并得到纯化的蛋白。K2和K3均含有维持PPZC酶活性的保守位点，但K3缺少
第262位的AsP。K2与一个来自欧洲样(凡g“:sylvatica)的FsPPZcZ有50%核
酸和67%的碱基相似性。
乙坛刀万沪2C2的表达模式与乙枯刀万沪2CI有些类似但存在一定差异。首先，受
BTH处理的时候，其表达比OsB仔沪2CI
预处理3d再接种稻瘟菌后，乙七刀护尸2口
更快，在24h即达到最高峰。其次，BTH
激发的速度比乙七丑序沪ZCj稍慢，但是强
浙江大学博士学位论文
度更高。第三，在与供试稻瘟菌分别表现亲和不亲和互作的水稻近等基因系HSR
和HSS中，非亲和品系HSR接种稻瘟菌后12h可见OsBIPPZCZ的诱导表达，而
在亲和品系HSS接种稻瘟菌对乙七刀刀邓心口没有明显的诱导。这些结果表明，
OsB万)P 2C2可能与水稻抗病相关。实验证明，水稻口‘刀护尸2口基因受到ABA诱
导表达;低温、千旱、创伤、重金属盐、高盐等各种逆境因子的诱导。为判别在
两个转录本中那一个对水稻的抗病和逆境适应中起作用，我们进行了RT一PCR。
结果表明，绝大多数的时候，只检测到心转录本。而幻转录本在伤口反应中可
能有极微量表达。
In the previous work of our lab, over 200 differential expressed cDNA from rice induced by benzothiadiazole (BTH) were cloned and identified through suppression subtractive hybridization. Among them, HIBI-n9 and BIHI-w2 with inserts of 414 bp and 755 bp, respectively, showed significant similarities to genes encoding known plant phosphatase 2C proteins. In order to elucidate the biological function of these two putative phosphatase 2C genes and their role in rice disease resistance, this study cloned and identified full-length cDNA of the genes and designated as OsBIPP2Cl and OsBIPP2C2, respectively.
The full-length cDNA of OsBIPP2Cl was isolated through a combination of virtual cloning and RACE. Rice ESTs matching to BIHI-w2 sequence were retrieved from dbEST of GenBank database and a single long sequence was assembled. The assembled sequence is of 1900 bp long and contains an open reading frame (ORF) of 1710 bp, which predicts to encode a protein of 569 amino acids with a calculated molecular weight of 58.7 kD and the isolectric point of 4.1. A signal peptide is predicted to locate from the first amino acid to the 39th amino acid at the N-terminus of the OsBIPP2Cl protein. The predicted protein sequence contains a protein phosphatase 2C domain, approximately 255 aa in length at its C terminus. In this domain, most of the amino acids that are required for binding Mg2+/Mn2+ ions to maintain catalytic activity were identified. The OsBEPP2Cl shares weak sequence identity to other PP2Cs identified so far, showing 13-16% of identity to Arabidopsis ABI2 and AtPP2CA, tobacco NtPP2Cl and Medicago MP2C. So it is
a new protein, we called it OsBEPP2Cl (Oryza_sativa L. BTHjnduced p_rotein phosphatase 2C 1, OsBIPP2Cl). The OsBIPP2Cl gene exists as single copy on the rice chromosome 3. As there is no phosphatase 2C gene identified in rice so far, we therefore concluded that OsBIPP2Cl is a novel gene encoding phosphatase 2C in rice.
OsBIPP2Cl was rapidly activated as soon as 6 hr after treatment by spraying with 0.3 mM BTH solution, maintained a relatively high level within 24 hr, and thereafter
declined gradually to the normal level at 72 hr after treatment. Inducible expression of OsBIPP2Cl was detected as early as 6 hr in BTH-treated rice seedlings after inoculation with the blast fungus, Magnaporthe grisea. This inducible expression was maintained at a relatively low level within the first 24 hr after inoculation. The significant induction was observed during the second 24 hr and then declined to normal level. In contrast, no obvious fluctuation of OsBIPP2Cl gene expression was detected in water-treated rice seedlings after inoculation. Meanwhile, OsBIPP2Cl was only slightly up-regulated by treatment with SA, but was strongly induced by 5 mM H2O2 within 12 hr after treatment. Moreover, OsBIPP2Cl was also found to be induced by salts, heavy metals and ABA, implying its multiple roles in stress acclimation. This is a common characteristic of some other stress-responsive PP2Cs such as ABI1 and ABE.
Coding sequence of OsBIPP2Cl was cloned to downstream of CaMV-35S promoter in the plant binary vector CHF3. Constructed vector was transformed into tobacco by Agrobacterium-mediated leaf disc transformation. A total of 13 transgenic lines were obtained through screening of antibiotic resistant re-generating seedlings and PCR detection. Northern blotting analysis showed that OsBIPP2Cl was expressed in most of the transgenic lines. Preliminary results showed the Tl plants of the OsBIPP2Cl-overexpressing lines enhanced the resistance to tobacco mosaic virus (TMV) and tobacco blank shank (Phytophthora parasitica var. nicotianae) diseases. Moreover, the transgenic Tl plants also showed an enhanced tolerance to salt and osmotic stress. The Tl generation of the transgenic lines showed a variable sensitivity to ABA as illustrated by germination rate of the seeds and seedling growth under ABA treatments.
Another PP2C gene was cloned by a similar way to that used in isolation of OsBIPP2Cl and was named as OsBIPP2C2 (Oryza
引文
宋东辉．2004．水稻抗病性相关的蛋白激酶基因OsBIMK2和OsBISERKl的克隆鉴定与功能分析．浙江大学博士学位论文．
Aarts N, Metz M, Holub E, Staskawicz B J, Daniels MJ, Parker JE. 1998. Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis. Proc. Natl. Acad. Sci. USA 95: 10306-10311.
Adachi J, Hasegawa M. 1992. MOLPHY: Programs for Molecular Phylogenetics. I. PROTML: Maximum Likelihood Inference for Protein Phylogeny, Computer Science Monographs, No. 27. Institute of Statistical Mathematics, Tokyo.
Agrawal GK, Rakwal R, Jwa NS, Agrawal VP. 2002. Effects of signaling molecules, protein phosphatase inhibitors and blast pathogen(Magnaporthe grisea) on the mRNA level of a rice (Oryza sativa L.)phospholipid hydroperoxide glutathione peroxidase(OsPHGPX) gene in seedling leaves. Gene 283: 227-236.
Agrawal, GK, Jwa NS, Rakwal R. 2000. A novel rice(Oryza sativa L.)acidic PR1 gene highly responsive to cut phytohormones, and protein phosphatase inhibitors. Biochem. Biophys. Res. Commun. 274: 157-165.
Allen GJ, Kuchitsu K, Chu SP, Murata Y, Schroeder JI. 1999. Ambidopsis abil-1 and abi2-1 phosphatase mutations reduce abscisic acid-induced cytoplasmic calcium rises in guard cells. Plant Cell 11: 1785-1798.
Andreeva AV, Hawes CR, Evans DE, Bennet N, Kutuzov MA. 1997. Genes of plant Ser/Thr protein phosphatases: detection of sequences related to PPT/rdgC. Bioorg. Khim. 23: 486-491.
Andreeva AV, Solov'eva OV, Kakuev DL, Kutuzov MA. 2001. Purification of plant protein phosphatase PP7 and evidence for its redox regulation. Arch. Biochem. Biophys. 396: 65-70.
Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J. 2002. MAP kinase signalling cascade in Arabidopsis innate immunity. Nature 415: 977-983.
Austin MJ, Muskett P, Kahn K Feys B J, Jones JDC, Parker JE. 2002. Regulatory role of SGT1 in early R gene-mediated plant defenses. Science 295: 2078-2080.
Azevedo C, Sadanandom A, Kitagawa K Freialdenhoven A, Shirasu K, Schulze-Leftrt P. 2002. The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance, Science 295: 2073-2076.
Barford D. 1996. Molecular mechanisms of the protein serine-threonine phosphatases. Trends Biochem Sci 21: 407-412.
Baudouin E, Meskiene I, Hirt H. 1999. Short communication: unsaturated fatty acids inhibit MP2C, a protein phosphatase 2C involved in the wound-induced MAP kinase pathway regulation. Plant J. 20: 343-348.
Becraft PW. 2002. Receptor kinase signaling in plant development. Annu. Rev. Cell Dev. Biol. 18: 163-192.
Belvin MP, Anderson K. 1996. A conserved signaling pathway: the Drosophila Toll-Dorsal pathway, Annu. Rev. Cell Dev. Biol. 12: 393-416.
Bertauche N, Leung J, Giraudat J. 1996. Protein phosphatase activity of abscisic acid insensitive 1(ABI1)protein from Arabidopsis thaliana. Eur. J. Biochem. 241: 193-200.
Blatt MR. 1990. Potassium channel currents in intact stomatal guard cells-rapid enhancement by abscisic acid. Planta 180: 445-455.
Blatt MR. 1992. K~+ channels of stomatal guard cells-characteristics of the inward rectifier and its control by pH. J. Gen. Physiol. 99: 615-644.
Blechert S, Brodschelm W, Holder S, Kammerer L, Kutchan TM, Mueller MJ, Xia Z, Zenk MH. 1995. The octadecanoic pathway: signal molecules for the regulation of secondary pathways. Proc. Natl. Acad. Sci. USA 92: 4099-4105.
Blume B, Numberger T, Nass N, Scheel D. 2000. Receptor-mediated increase in cytoplasmic free calcium required for activation of pathogen defense in parsley. Plant Cell 12: 1425-1440.
Bgre L, Ligterink W, Meskiene I, Barker PJ, Heberle-Bors E, Huskisson NS, Hirt H. 1997. Wounding induces the rapid and transient activation of a specific MAP kinase pathway. Plant Cell 9: 75-83.
Bowling SA, Clarke JD, Liu Y, Klessig DF, Dong X. 1997. The cpr5 mutant of Arabidopsis expresses both NPR 1-dependent and NPR 1-independent resistance. Plant Cell 9: 1573-1584.
Brandwagt BF, Mesbah LA, Takken FLW, Laurent PL, Kneppers TJA, Hille J, Nijkamp HJJ. 2000. A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. Proc. Natl. Acad. Sci. USA 97: 4961-4966.
Braun DM, Stone JM, Walker JC. 1997. Interaction of the maize and Arabidopsis kinase interaction domains with a subset of receptor-like protein kinases: implications for transmembrane signaling in plants. Plant J. 12: 83-95.
Broz AK, Thelen JJ, Muszynski MG, Miernyk JA, Randall DD. 2001. ZMPP2, a novel type-2C protein phosphatase from maize. J. Exp. Bot. 52: 1739-1740.
Brueggeman R, Rostoks N, Kudrna D, Kilian A, Han F, Chen J, Druka A, Steffenson B, Kleinhofs A. 2002. The barley stem rest-resistance gene Rpgl is a novel disease-resistance gene with homology to receptor kinases. Proc. Natl. Acad. Sci. USA 99: 9328-9333.
Bush DS. 1995. Calcium regulation in plant cells and its role in signaling. Annu. Rev. Plant Physiol. Plant Mol. Biol. 46: 95-122.
Cao H, Glazebrook J, Clarke JD, Volko S, Dong X. 1997. The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats. Cell 88: 57-63.
Carrasco JL, Ancillo G, Mayda E, Vera P. 2003. A novel transcription factor involved in plant defense endowed with protein phosphatase activity. EMBO J. 22: 3376-3384.
Century KS, Shapiro AD, Repetti PP, Dahlbeck D, Holub E, Staskawicz BJ 1997. NDR1, a pathogen-induced component required for Arabidopsis disease resistance. Science 278: 1963-1965.
Chen MX, McPartlin AE, Brown L, Chen YH, Barker HM, Cohen PTW. 1994. A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J. 13: 4278-4290.
Cheng J, Jennifer SB, Noel TK. 1998. Genetics of plant-pathogen interactions Current Opinion in Biotechnology 9: 202-207.
Chérel I, Michard E, Platet N, Mouline K, Alcon C, Sentena HC, Thibaud JB. 2002. Physical and functional interaction of the Arabidopsis K channel AKT2 and phosphatase AtPP2CA. Plant Cell 14: 1133-1146.
Clark SE, Running MP, Meyerowitz EM. 1993. CLAVATA1, a regulator of meristem and flower development in Arabidopsis. Development 119: 397-418.
Clark SE, Running MP, Meyerowitz EM. 1995. CLAVATA3 is a specific regulator of shoot and floral meristem development affecting the same processes as CLAVATA1. Development 121: 2057-2067.
Clark SE, Williams RW, Meyerowitz EM. 1997. The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis. Cell 89: 575-585.
Clarke A, Desikan R, Hurst RD, Hancock JT, Neill SJ. 2000. NO way back: nitric oxide and programmed cell death in Arabidopsis thaliana suspension cultures. Plant J. 24: 667-677.
Clarke JD, Liu Y, Klessig DF, Dong X. 1998. Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant. Plant Cell 10: 557-569.
Cohen P.1989 Structure and regulation of protein phosphatases. Ann Rev Biochem. 58: 453-508.
Conconi A, Miquel M, Browse JA, Ryan CA. 1996. Intracellular levels of free linolenic and linoleic acids increase in tomato leaves in response to wounding. Plant Physiol 111: 797-803.
Cooley MB, Pathirana S, Wu H J, Kachroo P, and Klessig DF. 2000 Members of the Arabidopsis HRT/RPP8 family of resistance genes confer resistance to both viral and Oomycete pathogens. Plant Cell 12: 663-676.
Costet L, Dorey S, Fritig B, Kauffmann S. 2002. A pharmacological approach to test the diffusible signal activity of reactive oxygen intermediates in elicitor-treated tobacco leaves. Plant Cell Physiol 43: 91-98.
Csortos C, Zolnierowicz S, Bako E, Durbin SD, Depaoli-Roach AA. 1996. High complexity in the expression of the B' subunit of protein phosphatase 2A-0. Evidence for the existence of at least seven novel isoforms. J. Biol. Chem. 271: 2578-2588.
Cutler AJ, Krochko JE. 1999.Formation and breakdown of ABA. Trends Plant Sci. 4: 472-478.
Cutler S, Ghassemian M, Bonetta D, Cooney S, Lemtiri-Chlieh F, MacRobbie EAC. 1994. Role of calcium in the modulation of Vicia guard cell potassium channels by abscisic acid-A patch-clamp study. J. Membr. Biol. 137: 99-107.
Cutler S, Ghassemian M, Bonetta D, Cooney S, McCourt P. 1996. A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis. Science 273: 1239-1241.
Dangl JL, Jones JD. 2001. Plant pathogens and integrated defense responses to infection. Nature 411: 826-833.
Das AK, Helps NR, Cohen PTW, Barford D. 1996. Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J. 15: 6798-6809.
de Bmxelles G L and Roberts MR.2001.Signals Regnlating Multiple Responses to Wounding and Herbivores Critical Reviews in Plant Sciences, 20: 487-521.
de Bruxelles GL, Peacock WJ, Dennis ES, Dolferus R. 1996. Abscisic acid induces the alcohol dehydrogenase gene in Arabidopsis. Plant Physiol 111: 381-391.
Delaney TP, Friedrich L, Ryals JA. 1995. Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance. Proc. Natl. Acad. Sci. USA 92: 6602-6606.
Delledonne M, Zeier J, Marocco A, Lamb C. 2001. Signal interactions between nitric oxide and reactive oxygen intermediates in the plant hypersensitive disease resistance response. Proc. Natl. Acad. Sci. USA 98: 13454-13459.
DeLong A, Mockaitis K, Christensen S. 2002. Protein phosphorylation in the delivery of and response to auxin signals. Plant Mol. Biol. 49: 285-303.
Deslandes L, Olivier J, Theulières F, Hirsch J, Feng DX, Bittner-Eddy P, Beynon J, Marco Y. 2002. Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene, a member of a novel family of resistance genes. Proc. Natl. Acad. Sci. USA 99: 2404-2409.
Despres C, DeLong C, Glaze S, Liu E, Fobert PR. 2000. The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors. Plant Cell 12: 279-290.
Dixon MS, Hatzixanthis K, Jones DA, Harrison K, Jones JD. 1998. The tomato Cf-5 disease resistance gene and six hyomologs show pronounced allelic variation in leucine-fich repeat copy number. Plant Cell 10: 1915-1926.
Dixon MS, Jones DA, Keddie JS, Thomas CM, Harrison K, and Jones JD. 1996. The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat proteins. Cell 84: 451-459.
Dong X. 1998. SA, JA, ethylene, and disease resistance in plants. Curr. Opin. Plant Biol. 1: 316-323.
Dunigan DD, Madlener JC. 1995. Serine/threonine protein phosphatase is required for tobacco mosaic virus-mediated programmed cell death. Virology 207: 460-466.
Eun SO, Bae SH, Lee Y. 2001. Cortical actin filaments in guard cells respond differently to abscisic acid in wild-type ancl abil-1 mutant Arabidopsis. Planta 212: 466-469.
Falk A, Feys BJ, Frost LN, Jones JD, Daniels MJ, Parker JE. 1999. EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Proc. Natl. Acad. Sci. USA 96: 3292-3297
Finkelstein RR, Lynch TJ. 2000. The Arabidopsis abscisic acid response gene ABI5 encodes a basic leucine zipper transcription factor. Plant Cell 12: 599-609.
Finkelstein RR, Somerville CR. 1990. Three classes of abscisic acid(ABA)-insensitive mutations of Arabidopsis define genes that control overlapping subsets of ABA responses. Plant Physiol. 94: 1172-1179
Finkelstein RR, Wang ML, Lynch TJ, Rao S, Goodman HM. 1998. The Arabidopsis abscisic acid response locus ABI4 encodes an APETALA2 domain protein. Plant Cell 10: 1043-1054.
Finkelstein RR. 1994. Mutations at two new Arabidopsis ABA response loci are similar to the abi3 mutations. Plant J. 5: 765-771.
Frye CA, Tang D, Innes RW. 2001. Negative regulation of defense responses in plants by a conserved MAPKK kinase. Proc Natl Acad Sci USA, 98:373-378.
Gaffney T, Friedrich L, Vemooij B, Negrotto D, Nye G, Uknes S,Ward E, Kessmann H, Ryals J.1993.Requirement for salicylic acid for the induction of systemic acquired resistance. Science, 261: 754-756.
Gale MD, Devos KM. 1998. Plant comparative genetics after 10 years Science 282: 656-659.
Gampala SS, Finkelstein RR, Sun SS, Rock CD. 2002. ABI5 interacts with abscisic acid signaling effectors in rice protoplasts. J. Biol. Chem. 277: 1689-1694.
Garbers C, DeLong A, Deruere J, Bemasconi P, Soll D. 1996 A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis. EMBO J. 15: 2115-2124.
Gelli A, Higgins VJ, Blumwald E. 1997. Activation of plant plasma membrane Ca~(2+)-permeable channels by race-specific fungal elicitors. Plant Physiol 113: 269-279.
Gilmour SJ, Thomashow MF. 1991. Cold acclimation and cold-regulated gone expression in ABA mutants of Arabidopsis thaliana. Plant Mol. Biol. 17: 1233-1240.
Gilmour SJ, Zarka DG, Stockinger EJ, Salazar MP, Houghton JM, Thomashow MF. 1998. Low temperature regulation of the Arabidopsis CBF family of AP2 transcriptional activators as an early step in cold-induced COR gene expression. Plant J. 16: 433-442.
Giraudat J, Hauge BM, Valon C, Smalle J, Parcy F, Goodman HM. 1992. Isolation of the Arabidopsis ABI3 gone by positional cloning. Plant Cell 4: 1251-1261.
Glazebrook J, Zook M, Mort F, Kagan I, Rogers EE, Crute IR, Holub EB, Hammerschmidt R, Ausubel FM. 1997. Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance. Genetics 146: 381-392.
Glazebrook J. 2001. Genes controlling expression of defense responses in Arabidopsis—2001 status Current Opinion in Plant Biology 4: 301-308.
Gomez-Gomez L, Bauer Z, Boller T. 2001. Both the extracellular leucine-rich repeat domain and the kinase activity of FSL2 are required for flagellin binding and signaling in Arabidopsis. Plant Cell 13: 1155-1163.
Gonzalez-Garcia MP, Rodriguez D, Nicolas C, Rodriguez PL, Nicolas G, Lorenzo O. 2003. Negative regulation of abscisic acid signaling by the Fagus sylvatica FsPP2C1 plays a role in seed dormancy regulation and promotion of seed germination. Plant Physiol. 133: 135-144.
Gorlach J, Volrath S, Knauf-Beiter G, Hengy G, Beckhove U, Kogel KH, Oostendorp M, Staub T, Ward E, Kessmann H, Ryals J, 1996. Benzothiadiazole, a novel class of inducers of systemic acquired resistance, activates gene expression and disease resistance in wheat. Plant Cell 8: 629-643.
Gosti F, Beaudoin N, Serizet C, Webb AAR, Vartanian N, Giraudat J. 1999. ABI1 protein phosphatase 2C is a negative regulator of abscisic acid signaling. Plant Cell 11: 1897-1910.
Grabov A, Leung J, Giraudat J, Blatt MR. 1997. Alteration of anion channel kinetics in wild-type and abil-1 transgenic Nicotiana benthamiana guard cells by abscisic acid. Plant J. 12: 203-213.
Grant M, Brown I, Adams S, Knight M, Ainslie A, Mansfield J. 2000. The RPM1 plant disease resistance gene facilitates a rapid and sustained increase in cytosolic calcium that is necessary for the oxidative burst and hypersensitive cell death. Plant J. 23: 441-50
Greenberg JT, Yao N. 2004. The role and regulation of programmed cell death in plant-pathogen interactions. Cell Microbiol. 6: 201-211.
Gu T, Mazzurco M, Sulaman W, Matias DD, Goring DR. 1998. Binding of an arm repeat protein to the kinase domain of the S-locus receptor kinase. Proc. Natl. Acad. Sci. USA 95:382-387.
Guan LM, Zhao J, Scandalios JG. 2000. Cis-elements and trans-factors that regulate expression of the maize Cat1 antioxidant gene in response to ABA and osmotic stress: H2O2 is the likely intermediary signaling molecule for the response. Plant J.22: 87-95.
Guo Y, Xiong L, Song CP, Gong D, Halfter U, Zhu JK. 2002. A calcium sensor and its interacting protein kinase are global regulators of abscisic acid signaling in Arabidopsis. Dev. Cell 3: 233-244.
Gupta R, Huang Y, Kieber J, Luan S. 1998. Identification of a dual-specificity protein phosphatase that inactivates a MAP kinase from Arabidopsis. Plant J. 16: 581-589.
Gupta V, Willits MG, Glazebrook J. 2000. Arabidopsis thaliana EDS4 contributes to salicylic acid(SA)-dependent expression of defense responses: evidence for inhibition of jasmonic acid signaling by SA. Mol. Plant Microbe Interact. 13: 503-11
Halfter U, Ishitani M, Zhu JK. 2000. The Arabidopsis SOS2 protein kinase physically interacts with and is activated by the calcium-binding protein SOS3. Proc. Natl. Acad. Sci. USA 97: 3735-3740.
Halterman D, Zhou F, Wei F, Wise RP, Schulze-Lefert P. 2001. The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria graminis f. sp. hordei in barley and wheat. Plant J. 25: 335-348.
Haneda M, Sugimoto T, Kikkawa R. 1999. Mitogen-activated protein kinase phosphatase: a
negative regulator of the mitogen-activated protein kinase cascade. Eur. d. Pharmacol. 365: 1-7.
Hanks SK, Hunter T. 1995. The eukaryotic protein kinase superfamily: kinase(catalytic)domain structure and classification. FASEB J 9: 576-596.
Hasegawa PM, Bressan RA, Zhu JK, Bohnert HJ. 2000. Plant cellular and molecular responses to high salinity. Annu. Rev. Plant Mol. Pl ant Physiol. 51: 463-499.
Hassa P, Granado J, Freydl E, Waspi U, Dudler R. 2000. Syringolin-mediated activation of the Pir7b esterase gene in rice cells is suppressed by phosphatase inhibitors. Mol. Plant Microbe Interact. 13: 342-346.
He Z, Wang ZY, Li J, Zhu Q,Lamb C, Ronald P, Chory J. 2000. Perception of brassinosteroids by the extra ellular domain of the receptor kinase BRI1. Science 288: 2360-2363.
He ZH, He D, Kohorn BD. 1998. Requirement for the induced expression of a cell wall associated receptor kinase for survival during the pathogen response. Plant J. 14: 55-63.
Hetherington A. Quatrano RS. 1991. Mechanisms of action of abscisic acid at the cellular level. New Phytologist 119: 9-32.
Higgins DG, Thompson JD, Gibson TJ. 1996. Using CLUSTAL for multiple sequence alignments. Methods Enzymol. 266: 383-402.
Himmelbach A, Hoffmann T, Leube M, Hohener B, Grill E. 2002. Homeodomain protein ATHB6 is a target of the protein phosphatase ABI1 and regulates hormone responses in Arabidopsis. EMBO J. 21: 3029-3038.
Hogue CW. 1997. Cn3D: a new generation of three-dimensional molecular structure viewer. Trends Biochem Sci. 22: 314-316.
Hubbard MJ, Cohen P. 1993. On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem Sci 18: 172-177.
Hunter T. 1995. Protein kinases and phosphotases: the yin and yang of protein phosphorylation and signaling. Cell 80: 225-236.
Ishikawa H, Aizawa H, Kishira H, Ogawa T, Sakata M. 1983. Light-induced changes of membrane potential in guard cells of Vicia faba. Plant Cell Physiol. 24: 769-772.
Jia Y, McAdams SA, Bryan GT, Hershey HP, and Valent B. 2000. Direct interaction of resistance gene and avirulence gene products confers rice blast resistance. EMBO J. 19: 4004-4014
Jirage D, Tootle TL, Reuber TL, Frost LN, Feys BJ, Parker JE,Ausubel FM, Glazebrook J. 1999, Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling. Proc Natl Acad Sci USA 1999, 96: 13583-13588.
Johal GS, Briggs SP. 1992. Reductase activity encoded by the HM1 disease resistance gene in maize. Science 258: 985-987.
Jonak C, Ligterink W, Hirt H. 1999. MAP kinases in plant signal transduction. Cell. Mol. Life Sci., 55: 204-213.
Jones DA, Thomas CM, Hammond-Kosack KE et al. 1994. Isolation of the tomato Cf-9 gene for resistance to Cladosporium fulvum by transposon tagging. Science 266: 789-793.
Jwa NS, Kumar AG, Rakwal R, Park CH, Prasad AV. 2001. Molecular cloning and characterization of a novel Jasmonate inducible pathogenesis-related class 10 protein gene, JIOsPR10, from rice(Oryza sativa L.)seedling leaves. Biochem. Biophys. Res. Commun. 286: 973-983.
Kanazin V, Marek LF, Shoemaker RC. 1996. Resistance gene analogs are conserved and clustered in soybean Proc. Natl. Acad. Sci. USA 93: 11746-11750.
Kapranov P, Jensen TJ, Poulsen C, de Bruijn FJ, Szczyglowski K. 1999. A protein phosphatase 2C gene, LjNPP2C 1, from Lotus japonicus induced during root nodule development. Proc. Natl. Acad. Sci. USA 96: 1738-1743.
Keates SE, Kostman TA, Anderson JD, Bailey BA. 2003. Altered gene expression in three plant species in response to treatment with Nep1, a fungal protein that causes necrosis. Plant Physiol 132: 1610-1622.
Keiko U Torii. 2000. Receptor kinase activation and signal transduction in plants: an emerging picture. Current Opinion in Plant Biology 3: 361-367
Kerk D, Bulgrien J, Smith DW, Barsam B, Veretnik S, Gribskov M. 2002. The complement of protein phosphatase catalytic subunits encoded in the genome of Arabidopsis. Plant Physiol 129: 908-925.
Kim CY, Gal SW, Choe MS, Jeong SY, Lee SI, Cheong YH, Lee SH, Choi YJ, Han CD, Kang KY, Cho MJ. 1998. A new class Ⅱ rice chitinase, Rcht2, whose induction by fungal elicitor is
abolished by protein phosphatase 1 and 2A inhibitor. Plant Mol. Biol. 37: 523-534.
Kitagawa K, Skowyra D, Elledge S J, Harper, JW, and Hieter P. 1999. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol. Cell 4: 21-33.
Klumpp S, Selke D, Hermesmeier J. 1998. Protein phosphatase type 2C active at physiological Mg2+: stimulation by unsaturated fatty acids. FEBS Lett. 437: 229-232.
Knight MR, Read ND, Campbell AK, Trewavas AJ. 1993. Imaging calcium dynamics in living plants using semi-synthetic recombinant aequorins. Journal of Cell Biology 121: 83-90.
Koornneef M, Alonso-Blanco C, Peeters AJM, Soppe W. 1998. Genetic control of flowering time in Arabidopsis. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49: 345-370.
Koornneef M, Reuling G, Karssen CM. 1984. The isolation and characterisation of abscisic acid-insensitive mutants of Arabidopsis thaliana. Physiol. Plant. 61: 377-383.
Kunkel BN, Brooks DN. 2002. Cross talk between signaling pathways in pathogen defense. Curr. Opin. Plant Biol. 5: 325-5331.
Kuromori T, Yamamoto M. 1994. Cloning of cDNAs from Arabidopsis thaliana that encode putative protein phosphatase 2C and a human Drl-like protein by transformation of a fission yeast mutant. Nucleic Acids Res. 22: 5296-5301.
Kwak SH, Lee SH. 1997. The requirements for Ca~(2+), protein phosphorylation, and dephosphorylation for ethylene signal transduction in Pisum sativum L. Plant Cell Physiol 38: 1142-1149.
Lacombe B, Pilot G, Michard E, Gaymard F, Sentenac H, Thibaud JB. 2000. A shaker-like K~+ channel with weak rectification is expressed in both source and sink phloem tissues of Arabidopsis. Plant Cell 12: 837-851.
Lamb C, Dixon RA. 1997. THE OXIDATIVE BURST IN PLANT DISEASE RESISTANCE. Annu. Rev. Plant Physiol Plant Mol. Biol. 48: 251-275
Lebrun-Garcia A, Ouaked F, Chiltz A, Pugin A. 1998. Activation of MAPK homologues by elicitors in tobacco cells. Plant J. 15: 773-781.
Lecourieux D, Mazars C, Pauly N, Ranjeva R, Pugin A. 2002 Analysis and effects of cytosolic free calcium increases in response to elicitors in Nicotiana plumbaginifolia cells. Plant Cell 14: 2627-2641
Lee GI, Ding Z, Walker JC, Van Doren SR. 2003. NMR structure of the forkhead-associated domain from the Arabidopsis receptor kinase-associated protein phosphatase. Proc. Natl. Acad. Sci. USA. 100: 11261-11266.
Lee S, Suh S, Crain RC, Kwak JM, Nam H-G, Lee Y. 1997. Systemic elevation of phosphatidic acid and lysophospholipid levels in wounded plants. Plant J. 12: 547-556.
Leister D, Kurth J, Laurie DA, Yano M, Sasaki T, Devos K, Graner A, and Schulze-Lefert P. 1998. Rapid reorganization of resistance gene homologues in cereal genomes. Proc. Natl. Acad. Sci. USA 95: 370-375.
Leister RT and Katagiri F. 2000. A resistance gene product of the nucleotide binding site-leucine rich repeat class can form a complex with bacterial avirulence proteins in vivo. Plant J. 22: 345-354.
Lemtiri-Chlieh F, and MacRobbie, EAC. 1994 Role of calcium in the modulation of Vicia guard cell potassium channels by abscisic acid: A patch clamp study. J. Membr. Biol. 137, 99-107.
Leung J, Merlot S, Giraudat J. 1997. The Arabidopsis ABSCISIC ACID-INSENSITIVE2(ABI2)and ABI1 genes encode homologous protein phosphatases 2C involved in abscisic acid signal transduction. Plant Cell 9: 759-771.
Leyser HMO, Fumer IJ. 1992. Characterization of three shoot apical meristem mutants of Arabidopsis thaliana. Development 116: 397-403.
Li J, Chory JA. 1997. Putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. Cell 90: 929-938.
Li J, Smith GR Walker JC. 1999. Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc. Natl. Acad. Sci. USA 96: 7821-7826.
Li X, Zhang Y, Clarke JD, Li Y, Dong X. 1999. Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1. Cell 98: 329-339.
Liotenberg S, North H, Marion-Poll A. 1999. Molecular biology and regulation of abscisic acid biosynthesis in plants. Plant Physiol. Biochem. 37: 341-350.
Liu J, Ishitani M, Halfter U, Kim CS, Zhu JK. 2000. The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance. Proc. Natl. Acad. Sci. USA 97: 3730-3734.
Liu Y, Schiff M, Serino G, Deng XW, Dinesh-Kumar SP. 2002. Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to Tobacco mosaic virus. Plant Cell 14: 1483-1496.
Long SR. 1989 Rhizobium-legume nodulation: Life together in the undergound. Cell 56: 203-214.
Lorenzo O, Nicolas C, Nicolas G, Rodriguez D. 2002 Molecular cloning of a functional protein phosphatase 2C(FsPP2C2) with unusual features and synergistically up-regulated by ABA and calcium in dormant seeds of Fagus sylvatica. Physiol. Plant. 114: 482-490.
Lorenzo O, Rodriguez D, Nicolas G, Rodriguez PL, Nicolas C. 2001. A new protein phosphatase 2C(FsPP2C1) induced by abscisic acid is specifically expressed in dormant beechnut seeds. Plant Physiol. 125: 1949-1956.
Luban J, Goff SP. 1995 The yeast two-hybrid system for studying protein-protein interactions. Curr. Opin. Biotechnol. 6: 59-64.
Luderer R, Rivas S, Nurnberger T, Mattei B, Van den Hooven HW, Van der Hoom RA, Romeis T, Wehrfritz JM, Blume B, Nennstiel D, Zuidema D, Vervoort J, De Lorenzo G, Jones JD, De Wit PJ, and Joosten MH. 2001. No evidence for binding between resistance gene product Cf-9 of tomato and avirulence gene product AVR9 of Cladosporium fulvum. Mol. Plant Microb Inter. 14: 867-876.
Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ. 2001. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292: 1382-1385.
MacKintosh C, Coggins J, Cohen P. 1991. Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase. Biochem. J. 273: 733-738.
MacRobbie EA. 1998. Signal transduction and ion channels in guard cells. Philos. Trans. R. Soc. Lond B Biol. Sci. 353: 1475-1488.
Maeda T, Wurgler-Murphy SM, Saito H. 1994. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369: 242-245.
Malamy J, Carr JP, Kiessig DF, Raskin I.1990. Salicylic Acid: A Likely Endogenous Signal in the Resistance Response of Tobacco to Viral Infection.science, 250: 1002-1004.
Marten I, Hoth S, Deeken R, Ache P, Ketchum KA, Hoshi T, Hedrich R. 1999. AKT3, a phloem-localized K~+ channel is blocked by protons. PNAS 96: 7581-7586.
Martin GB. Brommonschenkel SH. Chunwongse J. Frary A, Ganal MW, Spivey R, Wu T, Earle ED, and Tanksley SD. 1993. Map-based cloning of a protein kinase gene conferring disease resistance in tomato. Science. 262: 1432-1436.
Martinez C, Baccou JC, Bresson E, Baissac Y, Daniel JF, Jalloul A, Montillet JL, Geiger JP, Assigbetse K, Nicole M. 2000. Salicylic acid mediated by the oxidative burst is a key molecule in local and systemic responses of cotton challenged by an avirulent race of Xanthomonas campestris pv malvacearum. Plant Physiol 122: 757-766.
Mayda E, Marques C, Conejero V, Vera P. 2000. Expression of a pathogen-induced gene can be mimicked by auxin insensitivity. Mol. Plant Microbe Interact. 13: 23-31.
McAinsh MR, Brownlee C, Hetherington AM. 1990. Abscisic acid-induced elevation of guard cell cytoplasmic Ca~(2+) precedes stomatal closure. Nature 343: 186-188.
McAinsh MR, Brownlee C, Hetherington AM. 1992. Visualizing changes in cytoplasmic free Ca~(2+) during the response of stomatal guard cells to abscisic acid. Plant Cell 4: 1113-1122.
McDowell JM, Cuzick A, Can C, Beynon J, Dangl JL, Holub EB. 2000. Downy mildew(Peronospora parasitica)resistance genes in Arabidopsis vary in functional requirements for NDR1, EDS1, NPR1 and salicylic acid accumulation. Plant J. 22: 523-529
Merlot S, Gosti F, Guerrier D, Vavasseur A, Giraudat J. 2001. The ABI1 and ABI2 protein phosphatases 2C act in a negative feedback regulatory loop of the abscisic acid signalling pathway. Plant J. 25: 295-303.
Meskiene I, Baudouin E, Schweighofer A, Liwosz A, Jonak C, Rodriguez PL, Jelinek H, Hirt H. 2003. Stress-induced protein phosphatase 2C is a negative regulator of a mitogen-activated protein kinase. J. Biol. Chem. 278: 18945-18952.
Meskiene I, Bogre L, Glaser W, Balog J, Brandstotter M, Zwerger K, Ammerer G, Hirt H. 1998. MP2C, a plant protein phosphatase 2C, functions as a negative regulator of
mitogen-activated protein kinase pathways in yeast and plants. Proc. Natl. Acad. Sci. USA 95: 1938-1943.
Métraux JP, Signer H, Ryals J, Ward E, Wyss-Benz M, Gaudin J,Raschdorf K, Schmid E, Blum W, Inverardi B.1990 Increase in salicylicacid at the onset of systemic acquired resistance in cucumber. Science 250: 1004-1006.
Meyer K, Leube MP, Grill E. 1994. A protein phosphatase 2C involved in ABA signal transduction in Arabidopsis thaliana. Science 264: 1452-1455.
Meyers BC, Dickerman AW, Michelmore RW, Sivaramakrishnan S, Sobral BW, Young ND. 1999. Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily. Plant J. 20: 317-332.
Miyazaki S, Koga R, Bohnert HJ, Fukuhara T. 1999. Tissue- and environmental response-specific expression of 10 PP2C transcripts in Mesembryanthemum crystallinum. Mol. Gen. Genet. 261: 307-316.
Murata Y, Pei ZM, Mori IC, Schroeder J. 2001. Abscisic acid activation of plasma membrane Ca~(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abil-1 and abi2-1 protein phosphatase 2C mutants. Plant Cell 13: 2513-2523.
Muskett PR, Kahn K, Austin MJ, Moisan LJ, Sadanandom A, Shirasu K, Jones JD, Parker JE. 2002. Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Plant Cell 14: 979-992.
Mylona P, Pawlowski K, Bisseling T. 1995. Symbiotic nitrogen fixation. Plant Cell 7: 869-885.
Nambara E, Keith K, McCourt P, Naito S. 1995. A regulatory role for the ABI3 gene in the establishment of embryo maturation in Arabidopsis thaliana. Development 121: 629-636.
Nawrath C, Metraux JP. 1999. Salicylic acid induction-deficient mutants of Arabidopsis express PR-2 and PR-5 and accumulate high levels of camalexin after pathogen inoculation. Plant Cell 11: 1393-1404.
Nürnberger T, Scheel D. 2001. Signal transmission in the plant immune response Trends in Plant Science 6: 372-379.
O'Neill LAJ, Greene C. 1998. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants, J. Leukoc. Biol. 63: 650-657.
Ohta M, Guo Y, Halfter U, Zhu JK. 2003. A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2. Proc. Natl. Acad. Sci. USA 100: 11771-11776.
Ohta M, Liu J, Zhu JK. 1998. A calcium sensor homolog required for plant salt tolerance. Science 280: 1943-1945.
Ooms JJJ, Léon-Kloosterziel KM, Bagels D, Koornneef M, Karssen CM. 1993. Acquisition of desiccation tolerance and longevity in seeds of Arabidopsis thaliana. A comparative study using abscisic acid-insensitive abi3 mutants. Plant Physiol. 102: 1185-1191.
Pardo JM, Reddy MP, Yang S, Maggio A, Huh GH, Matsumoto T, Coca MA, Paino-D'Urzo M, Koiwa H, Yun DJ, Watad AA, Bressan RA, Hasegawa PM. 1998. Stress signaling through Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants. Proc. Natl. Acad. Sci. USA 95: 9681-9686.
Park AR, Cho SK, Yun UJ, Jin MY, Lee SH, Sachetto-Martins G, Park OK. 2001. Interaction of the Arabidopsis receptor protein kinase Wak1 with a glycine-rich protein, AtGRP-3. J. Biol. Chem. 276: 26688-26693.
Pato MD, Kerc E. 1991. Regulation of smooth muscle phosphatase-Ⅱ by divalent cations. Mol. Cell Biochem. 101: 31-41.
Pei ZM, Kuchitsu K, Ward JM, Schwarz M, Schroeder JI. 1997. Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abil and abi2 mutants. Plant Cell. 9: 409-423.
Penninckx IA, Thomma BP, Buchala A, Metraux JP, Broekaert WF. 1998. Concomitant activation of jasmonate and ethylene response pathways is required for induction of a plant defensin gene in Arabidopsis. Plant Cell 10: 2103-2113.
Pink D, Puddephat I. 1999. Deployment of disease resistance genes by plant transformation-a 'mix and match' approach. Trends in Plant Science 4: 71-75.
Pujol G, Ferrer A, Arino J. 1998. Protein phosphatase 2A and protein phosphatase X genes in Arabidopsis thaliana. Methods Mol. Biol. 93: 201-212.
Quinones-Mateu ME, Albright JL, Mas A, Soriano V, Arts EJ. 1998. Analysis of pol gene heterogeneity, viral quasispecies, and drug resistance in individuals infected with group O strains of human immunodeficiency virus type 1. J. Virol. 72: 9002-9015.
Raschke K. 1979. Movements of stomata. In Encyclopedia of Plant Physiology, Vol. 7, W. Haupt and E. Feinleib, eds(Berlin: Springer-Verlag), pp. 384-441.
Raskin I, Kende H 1984. Role of gibberellin in the growth response of submerged deep water rice. Plant Physiol 76: 947-950.
Rodriguez PL, keube MP, Grill E. 1998. Molecular cloning in Arabidopsis thaliana of a new protein phosphatase 2C(PP2C) with homology to ABI1 and ABI2. Plant Mol. Biol. 38: 879-883.
Rodriguez PL. 1998. Protein phosphatase 2C(PP2C) function in higher plants. Plant Mol. Biol. 38: 919-927.
Rojo E, Titarenko E, Leon J, Berger S, Vancanneyt G, Sanchez-Serrano JJ. 1998. Reversible protein phosphorytation regulates jasmonic acid-dependent and -independent wound signal transduction pathways in Arabidopsis thaliana. Plant J. 13: 153-165.
Ronald PC, Salmeron JM, Carland FM, Staskawicz BJ. 1992. The cloned avirulence gene avrPto induces disease resistance in tomato cultivars containing the Pto resistance gene, J. Bacteriol. 174: 1604-1611.
Ryals JA, Neuenschwander UH, Willits MG, Molina A, Steiner HY, Hunt MD. 1996. Systemic acquired resistance. Plant Cell 8: 1809-1819.
Ryu SB, Wang X. 1996. Activation of phospholipase D and the possible mechanism of activation in wound-induced lipid hydrolysis in castor bean leaves. Biochim. Biophys. Acta 1303: 243-250.
Savino G, Briat JF, Lobreaux S. 1997. Inhibition of the iron-induced ZmFerl maize ferritin gene expression by antioxidants and serine/threonine phosphatase inhibitors. J. Biol. Chem. 272: 33319-33326.
Schmidt C, Schelle I, Liao YJ, Schroeder JI. 1995. Strong regulation of slow anion channels and abscisic acid signaling in guard cells by phosphorylation and dephosphorylation events. Proc. Natl. Acad. Sci. USA 92: 9535-9539.
Schroeder JI, Hagiwara S. 1990. Repetitive increases in cytoplasmic Ca~(2+) of guard cells by abscisic acid activation of non-selective Ca~(2+)-permeable channels. Proc. Natl. Acad. Sci. USA 87: 9305-9309.
Schroeder JI, Hedrich R. 1989. Involvement of ion channels and active transport in osmoregulation and signaling of higher plant cells. Trends Biochem. Sci. 14: 187-192.
Schroeder JI, Keller BU. 1992. Two types of anion channel currents in guard cells with distinct voltage regulation. Proc. Natl. Acad. Sci. USA 89: 5025-5029.
Schroeder JI, Raschke K, Neher E. 1987. Voltage dependente of K~+ channels in guard cell protoplasts. Proc. Natl. Acad. Sci. USA 84: 4108-4112.
Schwechheimer C, Serino G, Callis J, Crosby WL, Lyapina S, Deshaies RJ, Gray WM, Estelle M, Deng XW. 2001. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science 292: 1379-1382.
Seo S, Okamoto M, Seto H, Ishizuka K, Sano H, Ohashi Y. 1995. Tobacco MAP kinase: a possible mediator in wound signal transduction pathways. Science 270: 1988-1992.
Shah K, Russinova E, Gadella TW, Jr. Willemse J, De Vries SC. 2002. The Arabidopsis kinase-associated protein phosphatase controls internalization of the somatic embryogenesis receptor kinase 1. Genes Dev. 16: 1707-1720.
Shah K, Vervoort J, de Vries SC. 2001. Role of threonines in the AtSERK1 activation loop in phosphorylation. J. Biol. Chem. 276: 41263-41269.
Sheen J. 1996. Ca~(2+)-dependent protein kinases and stress signal transduction in plants. Science 274: 1900-1902.
Sheen J. 1998. Mutational analysis of protein phosphatase 2C involved in abscisic acid signal transduction in higher plants. Proc. Natl. Acad. Sci. USA 95: 975-980.
Shen Q, Gomez-Cadenas A, Zhang P, Walker-Simmons MK, Sheen J, Ho TH. 2001. Dissection of abscisic acid signal transduction pathways in barley aleurone layers. Plant Mol. Biol. 47: 437-448.
Shen WH, Gigot C. 1997. Protein complexes binding to cis elements of the plant histone gene promoters: multiplicity, phosphorylation and cell cycle alteration. Plant Mol. Biol. 33:
367-379.
Shenolikar S, Brautigan DL. 2000. Meeting report: targeting protein phosphatases-medicines for the new millenium. Sci.STKE. 2000: E1.
Shiozaki K, Russell P. 1995. Counteractive roles of protein phosphatase 2C(PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast. EMBO J. 14: 492-502.
Shirasu K, Lahaye T, Tan MW, Zhou F, Azevedo C, and Schulze-Lefert P. 1999. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C-elegans. Cell 99: 355-366.
Soderman E, Hjellstrom M, Fahleson J, Engstrom P. 1999. The HD-Zip gene ATHB6 in Arabidopsis is expressed in developing leaves, roots and carpels and up-regulated by water deficit conditions. Plant Mol. Biol. 40: 1073-1083.
Soderman E, Mattsson J, Engstrom P. 1996. The Arabidopsis homeobox gene ATHB-7 is induced by water deficit and by abscisic acid. Plant J. 10: 375-381.
Song FM, Goodman RM. 2000 OsBIMK1, a rice MAP kinase gene involved in disease resistance responses. Planta 215: 997-1005.
Song WY, Wang GL, Chen LL Kim HS, Pi LY, Holsten T, Gardner J, Wang B, Zhai WX, Zhu LH. 1995. A receptor kinase-like protein encoded by the rice disease resistance gene Xa21. Science 270: 1804-1806.
Spaink HP. 2002. Plant-microbe interactions: a receptor in symbiotic dialogue. Nature 417: 910-911.
Staskawicz BJ, Mudgett MB, Dangl JL, Galan JE. 2001. Common and contrasting themes of plant and animal diseases. Science 292: 2285-2289.
Staswick PE, Su W, Howell S 1992. Methyl jasmonate inhibition of root growth and induction of a leaf protein are decreased in an Arabidopsis thaliana mutant. Proc. Natl. Acad. Sci. USA 89: 6837-6840.
Stone JM, Collinge MA, Smith RD, Horn MA, Walker JC. 1994. Interaction of a protein phosphatase with an Arabidopsis serine-threonine receptor kinase. Science 266: 793-795.
Stone JM, Trotochaud AE, Walker JC, Clark SE. 1998. Control of meristem development by CLAVATA1 receptor kinase and kinase-associated protein phosphatase interactions. Plant Physiol 117: 1217-1225.
Szczyglowski K, Hamburger D, Kapranov P, de Bruijn FJ. 1997. Construction of a Lotus japonicus late nodulin expressed sequence tag library and identification of novel nodule-specific genes. Plant Physiol. 114: 1335-1346.
Thtiharju S, Palva T. 2001. Antisense inhibition of protein phosphatase 2C accelerates cold acclimation in Arabidopsis thaliana. Plant J. 26: 461-470.
Takahashi A, Kawasaki T, Henmi K, Shii K, Kodama O, Satoh H, and Shimamoto K. 1999. Lesion mimic mutants of rice with alterations in early signaling events of defense. Plant J. 17: 535-545
Takken FLW, Joosten MHAJ. 2000. Plant resistance genes: their structure, function and evolution. Eur. J. Plant Pathol. 106: 699-713
Tamura S, Hanada M, Ohnishi M, Katsura K, Sasaki M, Kobayashi T. 2002. Regulation of stress-activated protein kinase signaling pathways by protein phosphatases. Eur. J. Biochem. 269: 1060-1066.
Tang X, Frederick RD, Zhou J, Halterman DA, Jia Y, Martin GB. 1996. Initiation of Plant Disease Resistance by Physical Interaction of AvrPto and Pto Kinase. Science 274: 2060-2063.
Taylor IB, Burbidage A, Thompson AJ. 2000. Control of abscisic acid synthesis. J. Exp. Bot. 51: 1563-1574.
Thiel G, MacRobbie EAC, Blatt MR. 1992. Membrane transport in stomatal guard cells: The importance of voltage control. J. Membr. Biol. 126: 1-18.
Thilmony RT, Chen Z, Bressan RA, Martin GB. 1995. Expression of the tomato Pto gene in tobacco enhances resistance to P. syringae pv. tabaci expressing avrPto, Plant Cell 7: 1529-1536.
Thomas CM, Jones DA, Parniske M, Harrison K, Balint-Kurti PJ, Hatzixanthis K, and Jones JD. 1997. Characterization of the tomato Cf-4 gene for resistance to Cladosporium fulvum identifies sequences that determine recognitional specificity in Cf-4 and Cf-9. Plant Cell 9: 2209-2224.
Thomashow MF. 1999. Plant cold acclimation: Freezing tolerance genes and regulatory
mechanisms. Annu. Rev. Plant Physiot. Plant Mol. Biol. 50: 571-599.
Thomma BP, Eggermont K, Tierens KF, Broekaert WF. 1999. Requirement of functional ethylene-insensitive 2 gene for efficient resistance of Arabidopsis to infection by Botrytis cinerea. Plant Physiol 121: 1093-1102.
Torii,K.U. 2000. Receptor kinase activation and signal transduction in plants: an emerging picture. Curr. Opin. Plant Biol. 3: 361-367.
Tornero P, Merritt P, Sadanandom A, Shirasu K, Innes RW, Dangl JL. 2002. RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Plant Cell 14: 1005-1015.
Torp J, Jorgensen JH. 1986. Modification of powdery mildew resistance gene Mla12 by induced mutation. Can J Genet Cytol 28: 725-731.
Trewavas AJ, Malhó R. 1997. Signal perception and transduction: The origin of the phenotype. Plant Cell 9: 1181-1195.
Van der Knaap, Song WY, Ruan DL, Sauter M, Ronald PC, Kende H. 1999. Expression of a gibberellin-induced leucine-rich repeat receptor-like protein kinase in deepwater rice and its interaction with kinase-associated protein phosphatase. Plant Physiol. 120: 559-570.
Vartanian N, Marcotte L, Giraudat J. 1994. Drought rhizogenesis in Arabidopsis thaliana. Differential responses of hormonal mutants. Plant Physiol. 104: 761-767.
Vera P, Tornero P, Conejero V. 1993. Cloning and expression analysis of a viroid-induced peroxidase from tomato plants. Mol. Plant Microbe Interact. 6: 790-794.
Verma DPS. 1992. Signals in root nodule organogenesis and endocytosis of Rhizobium. Plant Cell 4: 373-382.
Vranova E, Thtiharju S, Sriprang R, Willekens H, Heino P, Palva E, Inzé D, and Van Camp WV 2001. The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C. J. Exp. Bot. 52, 181-182.
Waegemann K, Soll J. 1996. Phosphorylation of the transit sequence of chloroplast precursor proteins. J. Biol. Chem. 271: 6545-6554.
Wang G-L, Ruan DL, Song WY, Sideris S, Chen L, Pi L-Y, Zhang S, Zhang Z, Fauquet C, Gaut BS, Whalen MC, Ronald PC. 1998. Xa21D encodes a receptor-like molecule with a leucine-rich repeat domain that determines racespecific recognition and is subjected to adaptive evolution. Plant Cell 10: 765-779.
Wang ML, Belmonte S, Kim U, Dolan M, Morris JW, Goodman HM. 1999. A cluster of ABA-regulated genes on Arabidopsis thaliana BAC T07M07. Genome Res. 9: 325-333.
Waskiewicz AJ, Cooper JA. 1995. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Opin. Cell. Biol. 7: 798-805.
Williams RW, Wilson JM, Meyerowitz EM. 1997. A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway. Proc. Natl. Acad. Sci. USA 94: 10467-10472.
Xiao SY, Ellwood S, Calis O, Patrick E, Li T, Coleman M, and Turner JG. 2001. Broad-Spectrum Mildew Resistance in Arabidopsis thaliana Mediated by RPWS. Science 291: 118-120.
Xing T, Malik K, Martin T, Miki BL. 2001. Activation of tomato PR and wound-related genes by a mutagenized tomato MAP kinase kinase through divergent pathways. Plant Mol. Biol. 46: 109-120.
Xiong L, Schumaker KS, Zhu JK. 1998. Arabidopsis abil-1 and abi2-1 phosphatase mutations reduce abscisic acid-induced cytoplasmic calcium rises in guard cells. Plant Cell 11: 1785-1798.
Xiong L, Schumaker KS, Zhu JK. 2002. Cell signaling during cold, drought, and salt stress. Plant Cell 14 Suppl: S165-S183.
Yamamoto S, Suzuki K, Shinshi H. 1999. Elicitor-responsive, ethylene-independent activation of GCC box-mediated transcription that is regulated by both protein phosphorylation and dephosphorylation in cultured tobacco cells. Plant J. 20: 571-579.
Yu LP, Miller AK, Clark SE. 2003. POLTERGEIST encodes a protein phosphatase 2C that regulates CLAVATA pathways controlling stem cell identity at Arabidopsis shoot and flower meristems. Curr. Biol. 13: 179-188.
Yu LP, Simon EJ, Trotochaud AE, Clark SE. 2000. POLTERGEIST functions to regulate meristem development downstream of the CLAVATA loci. Development 127: 1661-1670.
Yu YG, Buss GR, Maroof MAS. 1996. Isolation of a superfamily of candidate disease-resistance
genes in soybean based on a conserved nucleotide-binding site. Proc. Natl. Acad. Sci. USA 93: 11751-11756.
Zeevaart JAD, Creelman RA. 1988. Metabolism andphysiology of abscisic acid. Annu. Rev. Plant Physiol. Plant Mol. Biol. 39: 439-473.
Zhang C, Czymmek KJ, Shapiro AD. 2003. Nitric oxide does not trigger early programmed cell death events but may contribute to cell-to-cell signaling governing progression of the Arabidopsis hypersensitive response. Mol. Plant Microbe Interact. 16: 962-972.
Zhang X, Zhang L, Dong F, Gao J, Galbraith DW, Song CP. 2001. Hydrogen peroxide is involved in abscisic acid-induced stomatal closure in Vicia faba. Plant Physiol. 126: 1438-1448.
Zhang Y, Fan W, Kinkema M, Li X, Dong X. 1999. Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. Proc. Natl. Acad. Sci. USA 96: 6523-6528.
Zhou F, Kurth J, Wei F,Elliott C, Vale G, Yahiaoui N, Keller B, Somerville S, Wise R, and Schulze-Lefert P. 2001. Cell-autonomous expression of barley mlal confers race-specific resistance to the powdery mildew fungus via a rarl-independent signaling pathway. Plant Cell 13: 337-350.
Zhou J, Tang X, Martin GB. 1997. The Pto kinase conferring resistance to tomato bacterial speck disease interacts with proteins that bind a cis-element of pathogenesis-related genes. EMBO J. 16: 3207-3218.
Zhou JM, Trifa Y, Silva H, Pontier D, Lam E, Shah J, Klessig DF. 2000. NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid. Mol. Plant Microbe Interact. 13: 191-202.
Zhu JK, Liu J, Xiong L. 1998. Genetic analysis of salt tolerance in Arabidopsis. Evidence for a critical role of potassium nutrition. Plant Cell 10: 1181-1191.
Aarts N, Metz M, Holub E, Staskawicz B J, Daniels MJ, Parker JE. 1998. Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis. Proc. Natl. Acad. Sci. USA 95: 10306-10311.
Adachi J, Hasegawa M. 1992. MOLPHY: Programs for Molecular Phylogenetics. I. PROTML: Maximum Likelihood Inference for Protein Phylogeny, Computer Science Monographs, No. 27. Institute of Statistical Mathematics, Tokyo.
Agrawal GK, Rakwal R, Jwa NS, Agrawal VP. 2002. Effects of signaling molecules, protein phosphatase inhibitors and blast pathogen(Magnaporthe grisea) on the mRNA level of a rice (Oryza sativa L.)phospholipid hydroperoxide glutathione peroxidase(OsPHGPX) gene in seedling leaves. Gene 283: 227-236.
Agrawal, GK, Jwa NS, Rakwal R. 2000. A novel rice(Oryza sativa L.)acidic PR1 gene highly responsive to cut phytohormones, and protein phosphatase inhibitors. Biochem. Biophys. Res. Commun. 274: 157-165.
Allen GJ, Kuchitsu K, Chu SP, Murata Y, Schroeder JI. 1999. Ambidopsis abil-1 and abi2-1 phosphatase mutations reduce abscisic acid-induced cytoplasmic calcium rises in guard cells. Plant Cell 11: 1785-1798.
Andreeva AV, Hawes CR, Evans DE, Bennet N, Kutuzov MA. 1997. Genes of plant Ser/Thr protein phosphatases: detection of sequences related to PPT/rdgC. Bioorg. Khim. 23: 486-491.
Andreeva AV, Solov'eva OV, Kakuev DL, Kutuzov MA. 2001. Purification of plant protein phosphatase PP7 and evidence for its redox regulation. Arch. Biochem. Biophys. 396: 65-70.
Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J. 2002. MAP kinase signalling cascade in Arabidopsis innate immunity. Nature 415: 977-983.
Austin MJ, Muskett P, Kahn K Feys B J, Jones JDC, Parker JE. 2002. Regulatory role of SGT1 in early R gene-mediated plant defenses. Science 295: 2078-2080.
Azevedo C, Sadanandom A, Kitagawa K Freialdenhoven A, Shirasu K, Schulze-Leftrt P. 2002. The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance, Science 295: 2073-2076.
Barford D. 1996. Molecular mechanisms of the protein serine-threonine phosphatases. Trends Biochem Sci 21: 407-412.
Baudouin E, Meskiene I, Hirt H. 1999. Short communication: unsaturated fatty acids inhibit MP2C, a protein phosphatase 2C involved in the wound-induced MAP kinase pathway regulation. Plant J. 20: 343-348.
Becraft PW. 2002. Receptor kinase signaling in plant development. Annu. Rev. Cell Dev. Biol. 18: 163-192.
Belvin MP, Anderson K. 1996. A conserved signaling pathway: the Drosophila Toll-Dorsal pathway, Annu. Rev. Cell Dev. Biol. 12: 393-416.
Bertauche N, Leung J, Giraudat J. 1996. Protein phosphatase activity of abscisic acid insensitive 1(ABI1)protein from Arabidopsis thaliana. Eur. J. Biochem. 241: 193-200.
Blatt MR. 1990. Potassium channel currents in intact stomatal guard cells-rapid enhancement by abscisic acid. Planta 180: 445-455.
Blatt MR. 1992. K~+ channels of stomatal guard cells-characteristics of the inward rectifier and its control by pH. J. Gen. Physiol. 99: 615-644.
Blechert S, Brodschelm W, Holder S, Kammerer L, Kutchan TM, Mueller MJ, Xia Z, Zenk MH. 1995. The octadecanoic pathway: signal molecules for the regulation of secondary pathways. Proc. Natl. Acad. Sci. USA 92: 4099-4105.
Blume B, Numberger T, Nass N, Scheel D. 2000. Receptor-mediated increase in cytoplasmic free calcium required for activation of pathogen defense in parsley. Plant Cell 12: 1425-1440.
Bgre L, Ligterink W, Meskiene I, Barker PJ, Heberle-Bors E, Huskisson NS, Hirt H. 1997. Wounding induces the rapid and transient activation of a specific MAP kinase pathway. Plant Cell 9: 75-83.
Bowling SA, Clarke JD, Liu Y, Klessig DF, Dong X. 1997. The cpr5 mutant of Arabidopsis expresses both NPR 1-dependent and NPR 1-independent resistance. Plant Cell 9: 1573-1584.
Brandwagt BF, Mesbah LA, Takken FLW, Laurent PL, Kneppers TJA, Hille J, Nijkamp HJJ. 2000. A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. Proc. Natl. Acad. Sci. USA 97: 4961-4966.
Braun DM, Stone JM, Walker JC. 1997. Interaction of the maize and Arabidopsis kinase interaction domains with a subset of receptor-like protein kinases: implications for transmembrane signaling in plants. Plant J. 12: 83-95.
Broz AK, Thelen JJ, Muszynski MG, Miernyk JA, Randall DD. 2001. ZMPP2, a novel type-2C protein phosphatase from maize. J. Exp. Bot. 52: 1739-1740.
Brueggeman R, Rostoks N, Kudrna D, Kilian A, Han F, Chen J, Druka A, Steffenson B, Kleinhofs A. 2002. The barley stem rest-resistance gene Rpgl is a novel disease-resistance gene with homology to receptor kinases. Proc. Natl. Acad. Sci. USA 99: 9328-9333.
Bush DS. 1995. Calcium regulation in plant cells and its role in signaling. Annu. Rev. Plant Physiol. Plant Mol. Biol. 46: 95-122.
Cao H, Glazebrook J, Clarke JD, Volko S, Dong X. 1997. The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats. Cell 88: 57-63.
Carrasco JL, Ancillo G, Mayda E, Vera P. 2003. A novel transcription factor involved in plant defense endowed with protein phosphatase activity. EMBO J. 22: 3376-3384.
Century KS, Shapiro AD, Repetti PP, Dahlbeck D, Holub E, Staskawicz BJ 1997. NDR1, a pathogen-induced component required for Arabidopsis disease resistance. Science 278: 1963-1965.
Chen MX, McPartlin AE, Brown L, Chen YH, Barker HM, Cohen PTW. 1994. A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J. 13: 4278-4290.
Cheng J, Jennifer SB, Noel TK. 1998. Genetics of plant-pathogen interactions Current Opinion in Biotechnology 9: 202-207.
Chérel I, Michard E, Platet N, Mouline K, Alcon C, Sentena HC, Thibaud JB. 2002. Physical and functional interaction of the Arabidopsis K channel AKT2 and phosphatase AtPP2CA. Plant Cell 14: 1133-1146.
Clark SE, Running MP, Meyerowitz EM. 1993. CLAVATA1, a regulator of meristem and flower development in Arabidopsis. Development 119: 397-418.
Clark SE, Running MP, Meyerowitz EM. 1995. CLAVATA3 is a specific regulator of shoot and floral meristem development affecting the same processes as CLAVATA1. Development 121: 2057-2067.
Clark SE, Williams RW, Meyerowitz EM. 1997. The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis. Cell 89: 575-585.
Clarke A, Desikan R, Hurst RD, Hancock JT, Neill SJ. 2000. NO way back: nitric oxide and programmed cell death in Arabidopsis thaliana suspension cultures. Plant J. 24: 667-677.
Clarke JD, Liu Y, Klessig DF, Dong X. 1998. Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant. Plant Cell 10: 557-569.
Cohen P.1989 Structure and regulation of protein phosphatases. Ann Rev Biochem. 58: 453-508.
Conconi A, Miquel M, Browse JA, Ryan CA. 1996. Intracellular levels of free linolenic and linoleic acids increase in tomato leaves in response to wounding. Plant Physiol 111: 797-803.
Cooley MB, Pathirana S, Wu H J, Kachroo P, and Klessig DF. 2000 Members of the Arabidopsis HRT/RPP8 family of resistance genes confer resistance to both viral and Oomycete pathogens. Plant Cell 12: 663-676.
Costet L, Dorey S, Fritig B, Kauffmann S. 2002. A pharmacological approach to test the diffusible signal activity of reactive oxygen intermediates in elicitor-treated tobacco leaves. Plant Cell Physiol 43: 91-98.
Csortos C, Zolnierowicz S, Bako E, Durbin SD, Depaoli-Roach AA. 1996. High complexity in the expression of the B' subunit of protein phosphatase 2A-0. Evidence for the existence of at least seven novel isoforms. J. Biol. Chem. 271: 2578-2588.
Cutler AJ, Krochko JE. 1999.Formation and breakdown of ABA. Trends Plant Sci. 4: 472-478.
Cutler S, Ghassemian M, Bonetta D, Cooney S, Lemtiri-Chlieh F, MacRobbie EAC. 1994. Role of calcium in the modulation of Vicia guard cell potassium channels by abscisic acid-A patch-clamp study. J. Membr. Biol. 137: 99-107.
Cutler S, Ghassemian M, Bonetta D, Cooney S, McCourt P. 1996. A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis. Science 273: 1239-1241.
Dangl JL, Jones JD. 2001. Plant pathogens and integrated defense responses to infection. Nature 411: 826-833.
Das AK, Helps NR, Cohen PTW, Barford D. 1996. Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J. 15: 6798-6809.
de Bmxelles G L and Roberts MR.2001.Signals Regnlating Multiple Responses to Wounding and Herbivores Critical Reviews in Plant Sciences, 20: 487-521.
de Bruxelles GL, Peacock WJ, Dennis ES, Dolferus R. 1996. Abscisic acid induces the alcohol dehydrogenase gene in Arabidopsis. Plant Physiol 111: 381-391.
Delaney TP, Friedrich L, Ryals JA. 1995. Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance. Proc. Natl. Acad. Sci. USA 92: 6602-6606.
Delledonne M, Zeier J, Marocco A, Lamb C. 2001. Signal interactions between nitric oxide and reactive oxygen intermediates in the plant hypersensitive disease resistance response. Proc. Natl. Acad. Sci. USA 98: 13454-13459.
DeLong A, Mockaitis K, Christensen S. 2002. Protein phosphorylation in the delivery of and response to auxin signals. Plant Mol. Biol. 49: 285-303.
Deslandes L, Olivier J, Theulières F, Hirsch J, Feng DX, Bittner-Eddy P, Beynon J, Marco Y. 2002. Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene, a member of a novel family of resistance genes. Proc. Natl. Acad. Sci. USA 99: 2404-2409.
Despres C, DeLong C, Glaze S, Liu E, Fobert PR. 2000. The Arabidopsis NPR1/NIM1 protein enhances the DNA binding activity of a subgroup of the TGA family of bZIP transcription factors. Plant Cell 12: 279-290.
Dixon MS, Hatzixanthis K, Jones DA, Harrison K, Jones JD. 1998. The tomato Cf-5 disease resistance gene and six hyomologs show pronounced allelic variation in leucine-fich repeat copy number. Plant Cell 10: 1915-1926.
Dixon MS, Jones DA, Keddie JS, Thomas CM, Harrison K, and Jones JD. 1996. The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat proteins. Cell 84: 451-459.
Dong X. 1998. SA, JA, ethylene, and disease resistance in plants. Curr. Opin. Plant Biol. 1: 316-323.
Dunigan DD, Madlener JC. 1995. Serine/threonine protein phosphatase is required for tobacco mosaic virus-mediated programmed cell death. Virology 207: 460-466.
Eun SO, Bae SH, Lee Y. 2001. Cortical actin filaments in guard cells respond differently to abscisic acid in wild-type ancl abil-1 mutant Arabidopsis. Planta 212: 466-469.
Falk A, Feys BJ, Frost LN, Jones JD, Daniels MJ, Parker JE. 1999. EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Proc. Natl. Acad. Sci. USA 96: 3292-3297
Finkelstein RR, Lynch TJ. 2000. The Arabidopsis abscisic acid response gene ABI5 encodes a basic leucine zipper transcription factor. Plant Cell 12: 599-609.
Finkelstein RR, Somerville CR. 1990. Three classes of abscisic acid(ABA)-insensitive mutations of Arabidopsis define genes that control overlapping subsets of ABA responses. Plant Physiol. 94: 1172-1179
Finkelstein RR, Wang ML, Lynch TJ, Rao S, Goodman HM. 1998. The Arabidopsis abscisic acid response locus ABI4 encodes an APETALA2 domain protein. Plant Cell 10: 1043-1054.
Finkelstein RR. 1994. Mutations at two new Arabidopsis ABA response loci are similar to the abi3 mutations. Plant J. 5: 765-771.
Frye CA, Tang D, Innes RW. 2001. Negative regulation of defense responses in plants by a conserved MAPKK kinase. Proc Natl Acad Sci USA, 98:373-378.
Gaffney T, Friedrich L, Vemooij B, Negrotto D, Nye G, Uknes S,Ward E, Kessmann H, Ryals J.1993.Requirement for salicylic acid for the induction of systemic acquired resistance. Science, 261: 754-756.
Gale MD, Devos KM. 1998. Plant comparative genetics after 10 years Science 282: 656-659.
Gampala SS, Finkelstein RR, Sun SS, Rock CD. 2002. ABI5 interacts with abscisic acid signaling effectors in rice protoplasts. J. Biol. Chem. 277: 1689-1694.
Garbers C, DeLong A, Deruere J, Bemasconi P, Soll D. 1996 A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis. EMBO J. 15: 2115-2124.
Gelli A, Higgins VJ, Blumwald E. 1997. Activation of plant plasma membrane Ca~(2+)-permeable channels by race-specific fungal elicitors. Plant Physiol 113: 269-279.
Gilmour SJ, Thomashow MF. 1991. Cold acclimation and cold-regulated gone expression in ABA mutants of Arabidopsis thaliana. Plant Mol. Biol. 17: 1233-1240.
Gilmour SJ, Zarka DG, Stockinger EJ, Salazar MP, Houghton JM, Thomashow MF. 1998. Low temperature regulation of the Arabidopsis CBF family of AP2 transcriptional activators as an early step in cold-induced COR gene expression. Plant J. 16: 433-442.
Giraudat J, Hauge BM, Valon C, Smalle J, Parcy F, Goodman HM. 1992. Isolation of the Arabidopsis ABI3 gone by positional cloning. Plant Cell 4: 1251-1261.
Glazebrook J, Zook M, Mort F, Kagan I, Rogers EE, Crute IR, Holub EB, Hammerschmidt R, Ausubel FM. 1997. Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance. Genetics 146: 381-392.
Glazebrook J. 2001. Genes controlling expression of defense responses in Arabidopsis—2001 status Current Opinion in Plant Biology 4: 301-308.
Gomez-Gomez L, Bauer Z, Boller T. 2001. Both the extracellular leucine-rich repeat domain and the kinase activity of FSL2 are required for flagellin binding and signaling in Arabidopsis. Plant Cell 13: 1155-1163.
Gonzalez-Garcia MP, Rodriguez D, Nicolas C, Rodriguez PL, Nicolas G, Lorenzo O. 2003. Negative regulation of abscisic acid signaling by the Fagus sylvatica FsPP2C1 plays a role in seed dormancy regulation and promotion of seed germination. Plant Physiol. 133: 135-144.
Gorlach J, Volrath S, Knauf-Beiter G, Hengy G, Beckhove U, Kogel KH, Oostendorp M, Staub T, Ward E, Kessmann H, Ryals J, 1996. Benzothiadiazole, a novel class of inducers of systemic acquired resistance, activates gene expression and disease resistance in wheat. Plant Cell 8: 629-643.
Gosti F, Beaudoin N, Serizet C, Webb AAR, Vartanian N, Giraudat J. 1999. ABI1 protein phosphatase 2C is a negative regulator of abscisic acid signaling. Plant Cell 11: 1897-1910.
Grabov A, Leung J, Giraudat J, Blatt MR. 1997. Alteration of anion channel kinetics in wild-type and abil-1 transgenic Nicotiana benthamiana guard cells by abscisic acid. Plant J. 12: 203-213.
Grant M, Brown I, Adams S, Knight M, Ainslie A, Mansfield J. 2000. The RPM1 plant disease resistance gene facilitates a rapid and sustained increase in cytosolic calcium that is necessary for the oxidative burst and hypersensitive cell death. Plant J. 23: 441-50
Greenberg JT, Yao N. 2004. The role and regulation of programmed cell death in plant-pathogen interactions. Cell Microbiol. 6: 201-211.
Gu T, Mazzurco M, Sulaman W, Matias DD, Goring DR. 1998. Binding of an arm repeat protein to the kinase domain of the S-locus receptor kinase. Proc. Natl. Acad. Sci. USA 95:382-387.
Guan LM, Zhao J, Scandalios JG. 2000. Cis-elements and trans-factors that regulate expression of the maize Cat1 antioxidant gene in response to ABA and osmotic stress: H2O2 is the likely intermediary signaling molecule for the response. Plant J.22: 87-95.
Guo Y, Xiong L, Song CP, Gong D, Halfter U, Zhu JK. 2002. A calcium sensor and its interacting protein kinase are global regulators of abscisic acid signaling in Arabidopsis. Dev. Cell 3: 233-244.
Gupta R, Huang Y, Kieber J, Luan S. 1998. Identification of a dual-specificity protein phosphatase that inactivates a MAP kinase from Arabidopsis. Plant J. 16: 581-589.
Gupta V, Willits MG, Glazebrook J. 2000. Arabidopsis thaliana EDS4 contributes to salicylic acid(SA)-dependent expression of defense responses: evidence for inhibition of jasmonic acid signaling by SA. Mol. Plant Microbe Interact. 13: 503-11
Halfter U, Ishitani M, Zhu JK. 2000. The Arabidopsis SOS2 protein kinase physically interacts with and is activated by the calcium-binding protein SOS3. Proc. Natl. Acad. Sci. USA 97: 3735-3740.
Halterman D, Zhou F, Wei F, Wise RP, Schulze-Lefert P. 2001. The MLA6 coiled-coil, NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria graminis f. sp. hordei in barley and wheat. Plant J. 25: 335-348.
Haneda M, Sugimoto T, Kikkawa R. 1999. Mitogen-activated protein kinase phosphatase: a
negative regulator of the mitogen-activated protein kinase cascade. Eur. d. Pharmacol. 365: 1-7.
Hanks SK, Hunter T. 1995. The eukaryotic protein kinase superfamily: kinase(catalytic)domain structure and classification. FASEB J 9: 576-596.
Hasegawa PM, Bressan RA, Zhu JK, Bohnert HJ. 2000. Plant cellular and molecular responses to high salinity. Annu. Rev. Plant Mol. Pl ant Physiol. 51: 463-499.
Hassa P, Granado J, Freydl E, Waspi U, Dudler R. 2000. Syringolin-mediated activation of the Pir7b esterase gene in rice cells is suppressed by phosphatase inhibitors. Mol. Plant Microbe Interact. 13: 342-346.
He Z, Wang ZY, Li J, Zhu Q,Lamb C, Ronald P, Chory J. 2000. Perception of brassinosteroids by the extra ellular domain of the receptor kinase BRI1. Science 288: 2360-2363.
He ZH, He D, Kohorn BD. 1998. Requirement for the induced expression of a cell wall associated receptor kinase for survival during the pathogen response. Plant J. 14: 55-63.
Hetherington A. Quatrano RS. 1991. Mechanisms of action of abscisic acid at the cellular level. New Phytologist 119: 9-32.
Higgins DG, Thompson JD, Gibson TJ. 1996. Using CLUSTAL for multiple sequence alignments. Methods Enzymol. 266: 383-402.
Himmelbach A, Hoffmann T, Leube M, Hohener B, Grill E. 2002. Homeodomain protein ATHB6 is a target of the protein phosphatase ABI1 and regulates hormone responses in Arabidopsis. EMBO J. 21: 3029-3038.
Hogue CW. 1997. Cn3D: a new generation of three-dimensional molecular structure viewer. Trends Biochem Sci. 22: 314-316.
Hubbard MJ, Cohen P. 1993. On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem Sci 18: 172-177.
Hunter T. 1995. Protein kinases and phosphotases: the yin and yang of protein phosphorylation and signaling. Cell 80: 225-236.
Ishikawa H, Aizawa H, Kishira H, Ogawa T, Sakata M. 1983. Light-induced changes of membrane potential in guard cells of Vicia faba. Plant Cell Physiol. 24: 769-772.
Jia Y, McAdams SA, Bryan GT, Hershey HP, and Valent B. 2000. Direct interaction of resistance gene and avirulence gene products confers rice blast resistance. EMBO J. 19: 4004-4014
Jirage D, Tootle TL, Reuber TL, Frost LN, Feys BJ, Parker JE,Ausubel FM, Glazebrook J. 1999, Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling. Proc Natl Acad Sci USA 1999, 96: 13583-13588.
Johal GS, Briggs SP. 1992. Reductase activity encoded by the HM1 disease resistance gene in maize. Science 258: 985-987.
Jonak C, Ligterink W, Hirt H. 1999. MAP kinases in plant signal transduction. Cell. Mol. Life Sci., 55: 204-213.
Jones DA, Thomas CM, Hammond-Kosack KE et al. 1994. Isolation of the tomato Cf-9 gene for resistance to Cladosporium fulvum by transposon tagging. Science 266: 789-793.
Jwa NS, Kumar AG, Rakwal R, Park CH, Prasad AV. 2001. Molecular cloning and characterization of a novel Jasmonate inducible pathogenesis-related class 10 protein gene, JIOsPR10, from rice(Oryza sativa L.)seedling leaves. Biochem. Biophys. Res. Commun. 286: 973-983.
Kanazin V, Marek LF, Shoemaker RC. 1996. Resistance gene analogs are conserved and clustered in soybean Proc. Natl. Acad. Sci. USA 93: 11746-11750.
Kapranov P, Jensen TJ, Poulsen C, de Bruijn FJ, Szczyglowski K. 1999. A protein phosphatase 2C gene, LjNPP2C 1, from Lotus japonicus induced during root nodule development. Proc. Natl. Acad. Sci. USA 96: 1738-1743.
Keates SE, Kostman TA, Anderson JD, Bailey BA. 2003. Altered gene expression in three plant species in response to treatment with Nep1, a fungal protein that causes necrosis. Plant Physiol 132: 1610-1622.
Keiko U Torii. 2000. Receptor kinase activation and signal transduction in plants: an emerging picture. Current Opinion in Plant Biology 3: 361-367
Kerk D, Bulgrien J, Smith DW, Barsam B, Veretnik S, Gribskov M. 2002. The complement of protein phosphatase catalytic subunits encoded in the genome of Arabidopsis. Plant Physiol 129: 908-925.
Kim CY, Gal SW, Choe MS, Jeong SY, Lee SI, Cheong YH, Lee SH, Choi YJ, Han CD, Kang KY, Cho MJ. 1998. A new class Ⅱ rice chitinase, Rcht2, whose induction by fungal elicitor is
abolished by protein phosphatase 1 and 2A inhibitor. Plant Mol. Biol. 37: 523-534.
Kitagawa K, Skowyra D, Elledge S J, Harper, JW, and Hieter P. 1999. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol. Cell 4: 21-33.
Klumpp S, Selke D, Hermesmeier J. 1998. Protein phosphatase type 2C active at physiological Mg2+: stimulation by unsaturated fatty acids. FEBS Lett. 437: 229-232.
Knight MR, Read ND, Campbell AK, Trewavas AJ. 1993. Imaging calcium dynamics in living plants using semi-synthetic recombinant aequorins. Journal of Cell Biology 121: 83-90.
Koornneef M, Alonso-Blanco C, Peeters AJM, Soppe W. 1998. Genetic control of flowering time in Arabidopsis. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49: 345-370.
Koornneef M, Reuling G, Karssen CM. 1984. The isolation and characterisation of abscisic acid-insensitive mutants of Arabidopsis thaliana. Physiol. Plant. 61: 377-383.
Kunkel BN, Brooks DN. 2002. Cross talk between signaling pathways in pathogen defense. Curr. Opin. Plant Biol. 5: 325-5331.
Kuromori T, Yamamoto M. 1994. Cloning of cDNAs from Arabidopsis thaliana that encode putative protein phosphatase 2C and a human Drl-like protein by transformation of a fission yeast mutant. Nucleic Acids Res. 22: 5296-5301.
Kwak SH, Lee SH. 1997. The requirements for Ca~(2+), protein phosphorylation, and dephosphorylation for ethylene signal transduction in Pisum sativum L. Plant Cell Physiol 38: 1142-1149.
Lacombe B, Pilot G, Michard E, Gaymard F, Sentenac H, Thibaud JB. 2000. A shaker-like K~+ channel with weak rectification is expressed in both source and sink phloem tissues of Arabidopsis. Plant Cell 12: 837-851.
Lamb C, Dixon RA. 1997. THE OXIDATIVE BURST IN PLANT DISEASE RESISTANCE. Annu. Rev. Plant Physiol Plant Mol. Biol. 48: 251-275
Lebrun-Garcia A, Ouaked F, Chiltz A, Pugin A. 1998. Activation of MAPK homologues by elicitors in tobacco cells. Plant J. 15: 773-781.
Lecourieux D, Mazars C, Pauly N, Ranjeva R, Pugin A. 2002 Analysis and effects of cytosolic free calcium increases in response to elicitors in Nicotiana plumbaginifolia cells. Plant Cell 14: 2627-2641
Lee GI, Ding Z, Walker JC, Van Doren SR. 2003. NMR structure of the forkhead-associated domain from the Arabidopsis receptor kinase-associated protein phosphatase. Proc. Natl. Acad. Sci. USA. 100: 11261-11266.
Lee S, Suh S, Crain RC, Kwak JM, Nam H-G, Lee Y. 1997. Systemic elevation of phosphatidic acid and lysophospholipid levels in wounded plants. Plant J. 12: 547-556.
Leister D, Kurth J, Laurie DA, Yano M, Sasaki T, Devos K, Graner A, and Schulze-Lefert P. 1998. Rapid reorganization of resistance gene homologues in cereal genomes. Proc. Natl. Acad. Sci. USA 95: 370-375.
Leister RT and Katagiri F. 2000. A resistance gene product of the nucleotide binding site-leucine rich repeat class can form a complex with bacterial avirulence proteins in vivo. Plant J. 22: 345-354.
Lemtiri-Chlieh F, and MacRobbie, EAC. 1994 Role of calcium in the modulation of Vicia guard cell potassium channels by abscisic acid: A patch clamp study. J. Membr. Biol. 137, 99-107.
Leung J, Merlot S, Giraudat J. 1997. The Arabidopsis ABSCISIC ACID-INSENSITIVE2(ABI2)and ABI1 genes encode homologous protein phosphatases 2C involved in abscisic acid signal transduction. Plant Cell 9: 759-771.
Leyser HMO, Fumer IJ. 1992. Characterization of three shoot apical meristem mutants of Arabidopsis thaliana. Development 116: 397-403.
Li J, Chory JA. 1997. Putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. Cell 90: 929-938.
Li J, Smith GR Walker JC. 1999. Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc. Natl. Acad. Sci. USA 96: 7821-7826.
Li X, Zhang Y, Clarke JD, Li Y, Dong X. 1999. Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1. Cell 98: 329-339.
Liotenberg S, North H, Marion-Poll A. 1999. Molecular biology and regulation of abscisic acid biosynthesis in plants. Plant Physiol. Biochem. 37: 341-350.
Liu J, Ishitani M, Halfter U, Kim CS, Zhu JK. 2000. The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance. Proc. Natl. Acad. Sci. USA 97: 3730-3734.
Liu Y, Schiff M, Serino G, Deng XW, Dinesh-Kumar SP. 2002. Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to Tobacco mosaic virus. Plant Cell 14: 1483-1496.
Long SR. 1989 Rhizobium-legume nodulation: Life together in the undergound. Cell 56: 203-214.
Lorenzo O, Nicolas C, Nicolas G, Rodriguez D. 2002 Molecular cloning of a functional protein phosphatase 2C(FsPP2C2) with unusual features and synergistically up-regulated by ABA and calcium in dormant seeds of Fagus sylvatica. Physiol. Plant. 114: 482-490.
Lorenzo O, Rodriguez D, Nicolas G, Rodriguez PL, Nicolas C. 2001. A new protein phosphatase 2C(FsPP2C1) induced by abscisic acid is specifically expressed in dormant beechnut seeds. Plant Physiol. 125: 1949-1956.
Luban J, Goff SP. 1995 The yeast two-hybrid system for studying protein-protein interactions. Curr. Opin. Biotechnol. 6: 59-64.
Luderer R, Rivas S, Nurnberger T, Mattei B, Van den Hooven HW, Van der Hoom RA, Romeis T, Wehrfritz JM, Blume B, Nennstiel D, Zuidema D, Vervoort J, De Lorenzo G, Jones JD, De Wit PJ, and Joosten MH. 2001. No evidence for binding between resistance gene product Cf-9 of tomato and avirulence gene product AVR9 of Cladosporium fulvum. Mol. Plant Microb Inter. 14: 867-876.
Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ. 2001. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292: 1382-1385.
MacKintosh C, Coggins J, Cohen P. 1991. Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase. Biochem. J. 273: 733-738.
MacRobbie EA. 1998. Signal transduction and ion channels in guard cells. Philos. Trans. R. Soc. Lond B Biol. Sci. 353: 1475-1488.
Maeda T, Wurgler-Murphy SM, Saito H. 1994. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369: 242-245.
Malamy J, Carr JP, Kiessig DF, Raskin I.1990. Salicylic Acid: A Likely Endogenous Signal in the Resistance Response of Tobacco to Viral Infection.science, 250: 1002-1004.
Marten I, Hoth S, Deeken R, Ache P, Ketchum KA, Hoshi T, Hedrich R. 1999. AKT3, a phloem-localized K~+ channel is blocked by protons. PNAS 96: 7581-7586.
Martin GB. Brommonschenkel SH. Chunwongse J. Frary A, Ganal MW, Spivey R, Wu T, Earle ED, and Tanksley SD. 1993. Map-based cloning of a protein kinase gene conferring disease resistance in tomato. Science. 262: 1432-1436.
Martinez C, Baccou JC, Bresson E, Baissac Y, Daniel JF, Jalloul A, Montillet JL, Geiger JP, Assigbetse K, Nicole M. 2000. Salicylic acid mediated by the oxidative burst is a key molecule in local and systemic responses of cotton challenged by an avirulent race of Xanthomonas campestris pv malvacearum. Plant Physiol 122: 757-766.
Mayda E, Marques C, Conejero V, Vera P. 2000. Expression of a pathogen-induced gene can be mimicked by auxin insensitivity. Mol. Plant Microbe Interact. 13: 23-31.
McAinsh MR, Brownlee C, Hetherington AM. 1990. Abscisic acid-induced elevation of guard cell cytoplasmic Ca~(2+) precedes stomatal closure. Nature 343: 186-188.
McAinsh MR, Brownlee C, Hetherington AM. 1992. Visualizing changes in cytoplasmic free Ca~(2+) during the response of stomatal guard cells to abscisic acid. Plant Cell 4: 1113-1122.
McDowell JM, Cuzick A, Can C, Beynon J, Dangl JL, Holub EB. 2000. Downy mildew(Peronospora parasitica)resistance genes in Arabidopsis vary in functional requirements for NDR1, EDS1, NPR1 and salicylic acid accumulation. Plant J. 22: 523-529
Merlot S, Gosti F, Guerrier D, Vavasseur A, Giraudat J. 2001. The ABI1 and ABI2 protein phosphatases 2C act in a negative feedback regulatory loop of the abscisic acid signalling pathway. Plant J. 25: 295-303.
Meskiene I, Baudouin E, Schweighofer A, Liwosz A, Jonak C, Rodriguez PL, Jelinek H, Hirt H. 2003. Stress-induced protein phosphatase 2C is a negative regulator of a mitogen-activated protein kinase. J. Biol. Chem. 278: 18945-18952.
Meskiene I, Bogre L, Glaser W, Balog J, Brandstotter M, Zwerger K, Ammerer G, Hirt H. 1998. MP2C, a plant protein phosphatase 2C, functions as a negative regulator of
mitogen-activated protein kinase pathways in yeast and plants. Proc. Natl. Acad. Sci. USA 95: 1938-1943.
Métraux JP, Signer H, Ryals J, Ward E, Wyss-Benz M, Gaudin J,Raschdorf K, Schmid E, Blum W, Inverardi B.1990 Increase in salicylicacid at the onset of systemic acquired resistance in cucumber. Science 250: 1004-1006.
Meyer K, Leube MP, Grill E. 1994. A protein phosphatase 2C involved in ABA signal transduction in Arabidopsis thaliana. Science 264: 1452-1455.
Meyers BC, Dickerman AW, Michelmore RW, Sivaramakrishnan S, Sobral BW, Young ND. 1999. Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily. Plant J. 20: 317-332.
Miyazaki S, Koga R, Bohnert HJ, Fukuhara T. 1999. Tissue- and environmental response-specific expression of 10 PP2C transcripts in Mesembryanthemum crystallinum. Mol. Gen. Genet. 261: 307-316.
Murata Y, Pei ZM, Mori IC, Schroeder J. 2001. Abscisic acid activation of plasma membrane Ca~(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abil-1 and abi2-1 protein phosphatase 2C mutants. Plant Cell 13: 2513-2523.
Muskett PR, Kahn K, Austin MJ, Moisan LJ, Sadanandom A, Shirasu K, Jones JD, Parker JE. 2002. Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Plant Cell 14: 979-992.
Mylona P, Pawlowski K, Bisseling T. 1995. Symbiotic nitrogen fixation. Plant Cell 7: 869-885.
Nambara E, Keith K, McCourt P, Naito S. 1995. A regulatory role for the ABI3 gene in the establishment of embryo maturation in Arabidopsis thaliana. Development 121: 629-636.
Nawrath C, Metraux JP. 1999. Salicylic acid induction-deficient mutants of Arabidopsis express PR-2 and PR-5 and accumulate high levels of camalexin after pathogen inoculation. Plant Cell 11: 1393-1404.
Nürnberger T, Scheel D. 2001. Signal transmission in the plant immune response Trends in Plant Science 6: 372-379.
O'Neill LAJ, Greene C. 1998. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants, J. Leukoc. Biol. 63: 650-657.
Ohta M, Guo Y, Halfter U, Zhu JK. 2003. A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2. Proc. Natl. Acad. Sci. USA 100: 11771-11776.
Ohta M, Liu J, Zhu JK. 1998. A calcium sensor homolog required for plant salt tolerance. Science 280: 1943-1945.
Ooms JJJ, Léon-Kloosterziel KM, Bagels D, Koornneef M, Karssen CM. 1993. Acquisition of desiccation tolerance and longevity in seeds of Arabidopsis thaliana. A comparative study using abscisic acid-insensitive abi3 mutants. Plant Physiol. 102: 1185-1191.
Pardo JM, Reddy MP, Yang S, Maggio A, Huh GH, Matsumoto T, Coca MA, Paino-D'Urzo M, Koiwa H, Yun DJ, Watad AA, Bressan RA, Hasegawa PM. 1998. Stress signaling through Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants. Proc. Natl. Acad. Sci. USA 95: 9681-9686.
Park AR, Cho SK, Yun UJ, Jin MY, Lee SH, Sachetto-Martins G, Park OK. 2001. Interaction of the Arabidopsis receptor protein kinase Wak1 with a glycine-rich protein, AtGRP-3. J. Biol. Chem. 276: 26688-26693.
Pato MD, Kerc E. 1991. Regulation of smooth muscle phosphatase-Ⅱ by divalent cations. Mol. Cell Biochem. 101: 31-41.
Pei ZM, Kuchitsu K, Ward JM, Schwarz M, Schroeder JI. 1997. Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abil and abi2 mutants. Plant Cell. 9: 409-423.
Penninckx IA, Thomma BP, Buchala A, Metraux JP, Broekaert WF. 1998. Concomitant activation of jasmonate and ethylene response pathways is required for induction of a plant defensin gene in Arabidopsis. Plant Cell 10: 2103-2113.
Pink D, Puddephat I. 1999. Deployment of disease resistance genes by plant transformation-a 'mix and match' approach. Trends in Plant Science 4: 71-75.
Pujol G, Ferrer A, Arino J. 1998. Protein phosphatase 2A and protein phosphatase X genes in Arabidopsis thaliana. Methods Mol. Biol. 93: 201-212.
Quinones-Mateu ME, Albright JL, Mas A, Soriano V, Arts EJ. 1998. Analysis of pol gene heterogeneity, viral quasispecies, and drug resistance in individuals infected with group O strains of human immunodeficiency virus type 1. J. Virol. 72: 9002-9015.
Raschke K. 1979. Movements of stomata. In Encyclopedia of Plant Physiology, Vol. 7, W. Haupt and E. Feinleib, eds(Berlin: Springer-Verlag), pp. 384-441.
Raskin I, Kende H 1984. Role of gibberellin in the growth response of submerged deep water rice. Plant Physiol 76: 947-950.
Rodriguez PL, keube MP, Grill E. 1998. Molecular cloning in Arabidopsis thaliana of a new protein phosphatase 2C(PP2C) with homology to ABI1 and ABI2. Plant Mol. Biol. 38: 879-883.
Rodriguez PL. 1998. Protein phosphatase 2C(PP2C) function in higher plants. Plant Mol. Biol. 38: 919-927.
Rojo E, Titarenko E, Leon J, Berger S, Vancanneyt G, Sanchez-Serrano JJ. 1998. Reversible protein phosphorytation regulates jasmonic acid-dependent and -independent wound signal transduction pathways in Arabidopsis thaliana. Plant J. 13: 153-165.
Ronald PC, Salmeron JM, Carland FM, Staskawicz BJ. 1992. The cloned avirulence gene avrPto induces disease resistance in tomato cultivars containing the Pto resistance gene, J. Bacteriol. 174: 1604-1611.
Ryals JA, Neuenschwander UH, Willits MG, Molina A, Steiner HY, Hunt MD. 1996. Systemic acquired resistance. Plant Cell 8: 1809-1819.
Ryu SB, Wang X. 1996. Activation of phospholipase D and the possible mechanism of activation in wound-induced lipid hydrolysis in castor bean leaves. Biochim. Biophys. Acta 1303: 243-250.
Savino G, Briat JF, Lobreaux S. 1997. Inhibition of the iron-induced ZmFerl maize ferritin gene expression by antioxidants and serine/threonine phosphatase inhibitors. J. Biol. Chem. 272: 33319-33326.
Schmidt C, Schelle I, Liao YJ, Schroeder JI. 1995. Strong regulation of slow anion channels and abscisic acid signaling in guard cells by phosphorylation and dephosphorylation events. Proc. Natl. Acad. Sci. USA 92: 9535-9539.
Schroeder JI, Hagiwara S. 1990. Repetitive increases in cytoplasmic Ca~(2+) of guard cells by abscisic acid activation of non-selective Ca~(2+)-permeable channels. Proc. Natl. Acad. Sci. USA 87: 9305-9309.
Schroeder JI, Hedrich R. 1989. Involvement of ion channels and active transport in osmoregulation and signaling of higher plant cells. Trends Biochem. Sci. 14: 187-192.
Schroeder JI, Keller BU. 1992. Two types of anion channel currents in guard cells with distinct voltage regulation. Proc. Natl. Acad. Sci. USA 89: 5025-5029.
Schroeder JI, Raschke K, Neher E. 1987. Voltage dependente of K~+ channels in guard cell protoplasts. Proc. Natl. Acad. Sci. USA 84: 4108-4112.
Schwechheimer C, Serino G, Callis J, Crosby WL, Lyapina S, Deshaies RJ, Gray WM, Estelle M, Deng XW. 2001. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science 292: 1379-1382.
Seo S, Okamoto M, Seto H, Ishizuka K, Sano H, Ohashi Y. 1995. Tobacco MAP kinase: a possible mediator in wound signal transduction pathways. Science 270: 1988-1992.
Shah K, Russinova E, Gadella TW, Jr. Willemse J, De Vries SC. 2002. The Arabidopsis kinase-associated protein phosphatase controls internalization of the somatic embryogenesis receptor kinase 1. Genes Dev. 16: 1707-1720.
Shah K, Vervoort J, de Vries SC. 2001. Role of threonines in the AtSERK1 activation loop in phosphorylation. J. Biol. Chem. 276: 41263-41269.
Sheen J. 1996. Ca~(2+)-dependent protein kinases and stress signal transduction in plants. Science 274: 1900-1902.
Sheen J. 1998. Mutational analysis of protein phosphatase 2C involved in abscisic acid signal transduction in higher plants. Proc. Natl. Acad. Sci. USA 95: 975-980.
Shen Q, Gomez-Cadenas A, Zhang P, Walker-Simmons MK, Sheen J, Ho TH. 2001. Dissection of abscisic acid signal transduction pathways in barley aleurone layers. Plant Mol. Biol. 47: 437-448.
Shen WH, Gigot C. 1997. Protein complexes binding to cis elements of the plant histone gene promoters: multiplicity, phosphorylation and cell cycle alteration. Plant Mol. Biol. 33:
367-379.
Shenolikar S, Brautigan DL. 2000. Meeting report: targeting protein phosphatases-medicines for the new millenium. Sci.STKE. 2000: E1.
Shiozaki K, Russell P. 1995. Counteractive roles of protein phosphatase 2C(PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast. EMBO J. 14: 492-502.
Shirasu K, Lahaye T, Tan MW, Zhou F, Azevedo C, and Schulze-Lefert P. 1999. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C-elegans. Cell 99: 355-366.
Soderman E, Hjellstrom M, Fahleson J, Engstrom P. 1999. The HD-Zip gene ATHB6 in Arabidopsis is expressed in developing leaves, roots and carpels and up-regulated by water deficit conditions. Plant Mol. Biol. 40: 1073-1083.
Soderman E, Mattsson J, Engstrom P. 1996. The Arabidopsis homeobox gene ATHB-7 is induced by water deficit and by abscisic acid. Plant J. 10: 375-381.
Song FM, Goodman RM. 2000 OsBIMK1, a rice MAP kinase gene involved in disease resistance responses. Planta 215: 997-1005.
Song WY, Wang GL, Chen LL Kim HS, Pi LY, Holsten T, Gardner J, Wang B, Zhai WX, Zhu LH. 1995. A receptor kinase-like protein encoded by the rice disease resistance gene Xa21. Science 270: 1804-1806.
Spaink HP. 2002. Plant-microbe interactions: a receptor in symbiotic dialogue. Nature 417: 910-911.
Staskawicz BJ, Mudgett MB, Dangl JL, Galan JE. 2001. Common and contrasting themes of plant and animal diseases. Science 292: 2285-2289.
Staswick PE, Su W, Howell S 1992. Methyl jasmonate inhibition of root growth and induction of a leaf protein are decreased in an Arabidopsis thaliana mutant. Proc. Natl. Acad. Sci. USA 89: 6837-6840.
Stone JM, Collinge MA, Smith RD, Horn MA, Walker JC. 1994. Interaction of a protein phosphatase with an Arabidopsis serine-threonine receptor kinase. Science 266: 793-795.
Stone JM, Trotochaud AE, Walker JC, Clark SE. 1998. Control of meristem development by CLAVATA1 receptor kinase and kinase-associated protein phosphatase interactions. Plant Physiol 117: 1217-1225.
Szczyglowski K, Hamburger D, Kapranov P, de Bruijn FJ. 1997. Construction of a Lotus japonicus late nodulin expressed sequence tag library and identification of novel nodule-specific genes. Plant Physiol. 114: 1335-1346.
Thtiharju S, Palva T. 2001. Antisense inhibition of protein phosphatase 2C accelerates cold acclimation in Arabidopsis thaliana. Plant J. 26: 461-470.
Takahashi A, Kawasaki T, Henmi K, Shii K, Kodama O, Satoh H, and Shimamoto K. 1999. Lesion mimic mutants of rice with alterations in early signaling events of defense. Plant J. 17: 535-545
Takken FLW, Joosten MHAJ. 2000. Plant resistance genes: their structure, function and evolution. Eur. J. Plant Pathol. 106: 699-713
Tamura S, Hanada M, Ohnishi M, Katsura K, Sasaki M, Kobayashi T. 2002. Regulation of stress-activated protein kinase signaling pathways by protein phosphatases. Eur. J. Biochem. 269: 1060-1066.
Tang X, Frederick RD, Zhou J, Halterman DA, Jia Y, Martin GB. 1996. Initiation of Plant Disease Resistance by Physical Interaction of AvrPto and Pto Kinase. Science 274: 2060-2063.
Taylor IB, Burbidage A, Thompson AJ. 2000. Control of abscisic acid synthesis. J. Exp. Bot. 51: 1563-1574.
Thiel G, MacRobbie EAC, Blatt MR. 1992. Membrane transport in stomatal guard cells: The importance of voltage control. J. Membr. Biol. 126: 1-18.
Thilmony RT, Chen Z, Bressan RA, Martin GB. 1995. Expression of the tomato Pto gene in tobacco enhances resistance to P. syringae pv. tabaci expressing avrPto, Plant Cell 7: 1529-1536.
Thomas CM, Jones DA, Parniske M, Harrison K, Balint-Kurti PJ, Hatzixanthis K, and Jones JD. 1997. Characterization of the tomato Cf-4 gene for resistance to Cladosporium fulvum identifies sequences that determine recognitional specificity in Cf-4 and Cf-9. Plant Cell 9: 2209-2224.
Thomashow MF. 1999. Plant cold acclimation: Freezing tolerance genes and regulatory
mechanisms. Annu. Rev. Plant Physiot. Plant Mol. Biol. 50: 571-599.
Thomma BP, Eggermont K, Tierens KF, Broekaert WF. 1999. Requirement of functional ethylene-insensitive 2 gene for efficient resistance of Arabidopsis to infection by Botrytis cinerea. Plant Physiol 121: 1093-1102.
Torii,K.U. 2000. Receptor kinase activation and signal transduction in plants: an emerging picture. Curr. Opin. Plant Biol. 3: 361-367.
Tornero P, Merritt P, Sadanandom A, Shirasu K, Innes RW, Dangl JL. 2002. RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Plant Cell 14: 1005-1015.
Torp J, Jorgensen JH. 1986. Modification of powdery mildew resistance gene Mla12 by induced mutation. Can J Genet Cytol 28: 725-731.
Trewavas AJ, Malhó R. 1997. Signal perception and transduction: The origin of the phenotype. Plant Cell 9: 1181-1195.
Van der Knaap, Song WY, Ruan DL, Sauter M, Ronald PC, Kende H. 1999. Expression of a gibberellin-induced leucine-rich repeat receptor-like protein kinase in deepwater rice and its interaction with kinase-associated protein phosphatase. Plant Physiol. 120: 559-570.
Vartanian N, Marcotte L, Giraudat J. 1994. Drought rhizogenesis in Arabidopsis thaliana. Differential responses of hormonal mutants. Plant Physiol. 104: 761-767.
Vera P, Tornero P, Conejero V. 1993. Cloning and expression analysis of a viroid-induced peroxidase from tomato plants. Mol. Plant Microbe Interact. 6: 790-794.
Verma DPS. 1992. Signals in root nodule organogenesis and endocytosis of Rhizobium. Plant Cell 4: 373-382.
Vranova E, Thtiharju S, Sriprang R, Willekens H, Heino P, Palva E, Inzé D, and Van Camp WV 2001. The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C. J. Exp. Bot. 52, 181-182.
Waegemann K, Soll J. 1996. Phosphorylation of the transit sequence of chloroplast precursor proteins. J. Biol. Chem. 271: 6545-6554.
Wang G-L, Ruan DL, Song WY, Sideris S, Chen L, Pi L-Y, Zhang S, Zhang Z, Fauquet C, Gaut BS, Whalen MC, Ronald PC. 1998. Xa21D encodes a receptor-like molecule with a leucine-rich repeat domain that determines racespecific recognition and is subjected to adaptive evolution. Plant Cell 10: 765-779.
Wang ML, Belmonte S, Kim U, Dolan M, Morris JW, Goodman HM. 1999. A cluster of ABA-regulated genes on Arabidopsis thaliana BAC T07M07. Genome Res. 9: 325-333.
Waskiewicz AJ, Cooper JA. 1995. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Opin. Cell. Biol. 7: 798-805.
Williams RW, Wilson JM, Meyerowitz EM. 1997. A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway. Proc. Natl. Acad. Sci. USA 94: 10467-10472.
Xiao SY, Ellwood S, Calis O, Patrick E, Li T, Coleman M, and Turner JG. 2001. Broad-Spectrum Mildew Resistance in Arabidopsis thaliana Mediated by RPWS. Science 291: 118-120.
Xing T, Malik K, Martin T, Miki BL. 2001. Activation of tomato PR and wound-related genes by a mutagenized tomato MAP kinase kinase through divergent pathways. Plant Mol. Biol. 46: 109-120.
Xiong L, Schumaker KS, Zhu JK. 1998. Arabidopsis abil-1 and abi2-1 phosphatase mutations reduce abscisic acid-induced cytoplasmic calcium rises in guard cells. Plant Cell 11: 1785-1798.
Xiong L, Schumaker KS, Zhu JK. 2002. Cell signaling during cold, drought, and salt stress. Plant Cell 14 Suppl: S165-S183.
Yamamoto S, Suzuki K, Shinshi H. 1999. Elicitor-responsive, ethylene-independent activation of GCC box-mediated transcription that is regulated by both protein phosphorylation and dephosphorylation in cultured tobacco cells. Plant J. 20: 571-579.
Yu LP, Miller AK, Clark SE. 2003. POLTERGEIST encodes a protein phosphatase 2C that regulates CLAVATA pathways controlling stem cell identity at Arabidopsis shoot and flower meristems. Curr. Biol. 13: 179-188.
Yu LP, Simon EJ, Trotochaud AE, Clark SE. 2000. POLTERGEIST functions to regulate meristem development downstream of the CLAVATA loci. Development 127: 1661-1670.
Yu YG, Buss GR, Maroof MAS. 1996. Isolation of a superfamily of candidate disease-resistance
genes in soybean based on a conserved nucleotide-binding site. Proc. Natl. Acad. Sci. USA 93: 11751-11756.
Zeevaart JAD, Creelman RA. 1988. Metabolism andphysiology of abscisic acid. Annu. Rev. Plant Physiol. Plant Mol. Biol. 39: 439-473.
Zhang C, Czymmek KJ, Shapiro AD. 2003. Nitric oxide does not trigger early programmed cell death events but may contribute to cell-to-cell signaling governing progression of the Arabidopsis hypersensitive response. Mol. Plant Microbe Interact. 16: 962-972.
Zhang X, Zhang L, Dong F, Gao J, Galbraith DW, Song CP. 2001. Hydrogen peroxide is involved in abscisic acid-induced stomatal closure in Vicia faba. Plant Physiol. 126: 1438-1448.
Zhang Y, Fan W, Kinkema M, Li X, Dong X. 1999. Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. Proc. Natl. Acad. Sci. USA 96: 6523-6528.
Zhou F, Kurth J, Wei F,Elliott C, Vale G, Yahiaoui N, Keller B, Somerville S, Wise R, and Schulze-Lefert P. 2001. Cell-autonomous expression of barley mlal confers race-specific resistance to the powdery mildew fungus via a rarl-independent signaling pathway. Plant Cell 13: 337-350.
Zhou J, Tang X, Martin GB. 1997. The Pto kinase conferring resistance to tomato bacterial speck disease interacts with proteins that bind a cis-element of pathogenesis-related genes. EMBO J. 16: 3207-3218.
Zhou JM, Trifa Y, Silva H, Pontier D, Lam E, Shah J, Klessig DF. 2000. NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid. Mol. Plant Microbe Interact. 13: 191-202.
Zhu JK, Liu J, Xiong L. 1998. Genetic analysis of salt tolerance in Arabidopsis. Evidence for a critical role of potassium nutrition. Plant Cell 10: 1181-1191.