川参通联合α_(1A)受体阻滞剂治疗Ⅲ型前列腺炎的临床研究
|
摘要
目的:评价川参通注射液联合α_(1A)受体阻滞剂治疗Ⅲ型前列腺炎血瘀证的临床疗效。
方法:本项研究将60例符合纳入标准的患者分为随机分为两组:川参通组(n=30),经会阴部前列腺局部注射川参通注射液及口服盐酸坦洛新缓释胶囊;对照组(n=30),口服盐酸坦洛新缓释胶囊;临床治疗18天。于治疗前、治疗后、停药后1个月测定慢性前列腺炎症状指数评分(NIH-CPSI)、慢性前列腺炎中医辨证评分、最大尿流率及残余尿量,并对上述结果进行统计学分析。
结果:1、川参通组治疗后及停药后1个月疗效均优于对照组;川参通组停药后1个月较治疗后疗效无明显变化;但对照组停药后1个月较治疗后疗效明显降低。2、川参通组及对照组在治疗后及停药后1个月均能较好的改善患者的NIH-CPSI总积分、疼痛积分、尿道症状积分、生活质量评分、中医辨证评分、最大尿流率、残余尿量,但川参通组改善情况明显优于对照组。3、川参通组NIH-CPSI总积分、疼痛积分、尿道症状积分、生活质量评分、中医辨证评分、最大尿流率、残余尿量停药后1个月与治疗后比较均无明显改变;而对照组停药后1个月较治疗后明显恶化。
结论:川参通注射液联合α_(1A)受体阻滞剂是治疗Ⅲ型前列腺炎的有效方法,在改善患者临床症状、生活质量及下尿路梗阻上具有独特的优势,并能有效延缓或减少病情的复发。
Objective:To evaluate the efficacy that Chuanshentong and alpha-1A receptor blockader treat Chronic Prostatitis/Chronic Pelvic Pain Syndromes with syndrome types of Xueyu.
Methods:The patients who would be consistent with the inclusion criteria were divided into two groups randomly:Chuanshentong group(n=30),injected Chuanshentong injection into the prostate by perineal and took tamsulosin hydrochloride release capsules for 18 days. Control group(n=30),took tamsulosin hydrochloride release capsules for 18 days.Every group was examined with the National Institutes of Health chronic prostatitis symptom index(NIH-CPSI),chronic prostatitis Traditional Chinese Medicine(TCM) score,maximum urinary flow rate and residual urine volume at pre-treatment,post-treatment and one month drug off-application.These results were statistically analyzed.
Result:1.The efficacy of Chuanshentong group were better than the efficacy of control group at post-treatment and one month drug off-application.The efficacy of Chuanshentong group at one month drug off-application was not significantly changed compared with post-treatment.But the efficacy of Control group was decreased significantly.2.The Chuanshentong group and the control group had able to improve the patient's NIH-CPSI total score,pain score,urinary tract symptom score,quality of life score,TCM score, maximum flow rate,residual urine volume at post-treatment and one month drug off-application.However,Chuanshentong group to improve the situation was better than the control group.3.It was no significantly change in the NIH-CPSI total score,pain score, urinary tract symptom score,quality of life score,TCM score,maximum urinary flow rate, residual urine volume of Chuanshentong group between the period of one month drug off-application and post-treatment,but the control group was aggravation.
Conclusion:It is a effective way to treat CP/CPPS with chuanshentong and alpha-1A receptor blockader.It has unique advantages to improve the clinical symptoms,quality of life and on lower urinary tract obstruction,and can effectively delay or reduce the pathogenetic condition relapse.
方法:本项研究将60例符合纳入标准的患者分为随机分为两组:川参通组(n=30),经会阴部前列腺局部注射川参通注射液及口服盐酸坦洛新缓释胶囊;对照组(n=30),口服盐酸坦洛新缓释胶囊;临床治疗18天。于治疗前、治疗后、停药后1个月测定慢性前列腺炎症状指数评分(NIH-CPSI)、慢性前列腺炎中医辨证评分、最大尿流率及残余尿量,并对上述结果进行统计学分析。
结果:1、川参通组治疗后及停药后1个月疗效均优于对照组;川参通组停药后1个月较治疗后疗效无明显变化;但对照组停药后1个月较治疗后疗效明显降低。2、川参通组及对照组在治疗后及停药后1个月均能较好的改善患者的NIH-CPSI总积分、疼痛积分、尿道症状积分、生活质量评分、中医辨证评分、最大尿流率、残余尿量,但川参通组改善情况明显优于对照组。3、川参通组NIH-CPSI总积分、疼痛积分、尿道症状积分、生活质量评分、中医辨证评分、最大尿流率、残余尿量停药后1个月与治疗后比较均无明显改变;而对照组停药后1个月较治疗后明显恶化。
结论:川参通注射液联合α_(1A)受体阻滞剂是治疗Ⅲ型前列腺炎的有效方法,在改善患者临床症状、生活质量及下尿路梗阻上具有独特的优势,并能有效延缓或减少病情的复发。
Objective:To evaluate the efficacy that Chuanshentong and alpha-1A receptor blockader treat Chronic Prostatitis/Chronic Pelvic Pain Syndromes with syndrome types of Xueyu.
Methods:The patients who would be consistent with the inclusion criteria were divided into two groups randomly:Chuanshentong group(n=30),injected Chuanshentong injection into the prostate by perineal and took tamsulosin hydrochloride release capsules for 18 days. Control group(n=30),took tamsulosin hydrochloride release capsules for 18 days.Every group was examined with the National Institutes of Health chronic prostatitis symptom index(NIH-CPSI),chronic prostatitis Traditional Chinese Medicine(TCM) score,maximum urinary flow rate and residual urine volume at pre-treatment,post-treatment and one month drug off-application.These results were statistically analyzed.
Result:1.The efficacy of Chuanshentong group were better than the efficacy of control group at post-treatment and one month drug off-application.The efficacy of Chuanshentong group at one month drug off-application was not significantly changed compared with post-treatment.But the efficacy of Control group was decreased significantly.2.The Chuanshentong group and the control group had able to improve the patient's NIH-CPSI total score,pain score,urinary tract symptom score,quality of life score,TCM score, maximum flow rate,residual urine volume at post-treatment and one month drug off-application.However,Chuanshentong group to improve the situation was better than the control group.3.It was no significantly change in the NIH-CPSI total score,pain score, urinary tract symptom score,quality of life score,TCM score,maximum urinary flow rate, residual urine volume of Chuanshentong group between the period of one month drug off-application and post-treatment,but the control group was aggravation.
Conclusion:It is a effective way to treat CP/CPPS with chuanshentong and alpha-1A receptor blockader.It has unique advantages to improve the clinical symptoms,quality of life and on lower urinary tract obstruction,and can effectively delay or reduce the pathogenetic condition relapse.
引文
1 Roberts RO,Lieber M M,Bostwick DG.et al.A review of clinic pathological prostatitis syndrome[J].Urology,1997,49(6):809.
2 马汉彬,陈复纯,肖广潮.慢性前列腺炎患者的尿动力学检查[J].河北医学,2006,16(3):205-207.
3 Bahk JY,Hyun Js,Lee JY.Concentration of ofloxacin in canine Prostate tissue and Prostate fluid after intraptos ratic iniecrion of biode-gradable sustained-releasing microspheres containing oflosacin[J].J Urol,2000,163(5):1560-1564.
4 中华医学会泌尿外科学分会.中国前列腺炎诊断治疗指南[M].中华医学信息导报,2006,19.
5 中国中西医结合学会男科专业委员会.慢性前列腺炎中西医结合诊疗指南[J].中国中西医结合杂志,2007,27(11):1052-1056.
6 贾金铭,薛慈民.前列安栓治疗慢性前列腺炎的疗效和安全性[J].中华男科,2001,7(6):417-419.
7 梁朝朝,张学军,王克孝.前列腺炎病因学研究进展[J].中华泌尿外科杂志,2003,6:26-28.
8 Krieger JNK,Riley DE.Bacteria in the chronic prostatitis-chronic pelvic pain syndrome:molecular approaches to critical research questions[J].JUrol,2002,167(6):2574-2583.
9 郭应禄,李宏军.前列腺炎[M].北京:人民军医出版社.2002.99-121.
10 Collins MM,Stafford RS,O' Leary MP,et al.Distinguishing chronic prostatitis and benign prostatic hyperplasia symptoms:results of a national survey of physician visits[J].Urology,1999,53:921-925.
11 鲍镇美.前列腺尿液返流与前列腺炎[J].中华泌尿外科杂志,1995,16(6):380.
12 何乐叶.前列腺炎综合征[J].中华泌尿外科杂志,1998,21(6):288-289.
13 Barbalias GA.Clinical and theraputical guidelines for chronic prostatitis[J].Eur Urol,2000,37(1).116-117.
14 吴荣佩,郑克立,胡红星,等.α_1 受体阻滞药治疗慢性前列腺炎疗效观察[J].临床泌尿外科杂志,2001,16(5):207-208.
15 顾方六.现代前列腺病学[M].北京:人民军医出版社,2002:541.
16 秦云峰.对中医“男胞”—前列腺生理功能再认识[J].中华男科学,2003,9(1):76-78.
17 张敏建.前列腺痛的中西医结合防与治[J].中国中西医结合杂志.2002,22(3):219.
18 高兆旺,宋景贵,张丽.论精室瘀阻是慢性前列腺炎的主要病机[J].山东中医药大学学报,2001,25(5),335-337.
19 高学敏.中药学[M].北京:中国中医药出版社,2004,2.
20 颜鸿,安国术.川参通注射液治疗慢性前列腺炎临床疗效观察(附342例治疗报告)[J].临床医药实践杂志,2008,17(9):743-744.
21 Lummus WE,Thompson I.Prostatitis[J].Emerg Ned Clin North Am,2001,19(3):691- 707.
22 梁宏,邓春华,李伟明,等.尿道前列腺返流显像及其在慢性前列腺炎中的应用[J].中华核医学杂志,1999,19(2):98-99.
23 Schaeffer AJ.National Institutes of Health Chronic Prostatitis Symptom Indexfor Japanese men[J].J Urol,2003,169(4):1616.
24 Cho L R,Keener T S,Nghiem H V,et al.Prostate blood flow characteristics in the chronic prastatitis/pelvic pain syndrome[J].Urol,2000,163:1130-1133.
25 Mehik A,Hellstrom P,Lukkarijen O,et al.Increased intraprostatic pressure in patients with chronic prostatitis[J].Urol Rest,1999,27:277-279.
26 沈柏华,金晓东,蔡松良,等.α_1受体阻滞剂联合抗生素治疗慢性前列腺炎疗效及机制[J].中华男科学杂志,2004,10(7):518-520.
27 许明,张永康,邹秋锋.慢性非细菌性前列腺炎尿流动力学改变及其对α_1受体阻断剂的反应[J].中国临床医学2002,9(4):371-373.
28 Nickel JC,Alexander RB,Schaeffer AJ,et al.Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls[J].J Urol,2003,170(3):818-822.
29 吴阶平.吴阶平泌尿外科学[M].山东科学技术出版社,2005,2.
30 吴洪涛,刘紫庭,杨罗艳.川参通对大鼠前列腺组织影响的实验研究[J].中国临床康复,2005,9(2):188-190.
31 王洁,张均田.总丹酚酸抗脑缺血与抗血栓的关系[J].中国药理学通报,1999.15(3):237-239.
32 陈进红.川芎素低分子右旋糖酐治疗急性脑梗死的对照研究[J].中国中西医结合杂志.1992,12(2):72.
33 李玉吉.全髋关节置换术后下肢深静脉血栓形成的治疗过程中D-二聚体的变化[J].中华实用中西医杂志.2006,19(5):558-559.
34 巫少荣,李自成,裘汉璋.当归在心血管系统的作用[J].中医药研究,2001,17(3):56-58.
35 谢可鸣,居颂光,顾永平,等.当归对体内外血吸虫卵肉芽肿反应抑制作用的实验研究[J].中国病理生理杂志,2002;18(9):1122-1125.
36 袁新初,张端莲.当归注射液对更年期大鼠超氧化物歧化酶和脂质过氧化物的影响[J].中草药,2001:32(9):822-823.
37 张旭,张超英,王文,等.麦冬药物血清对血管内皮细胞凋亡相父基因表达及胞内ca~(2+) 的影响[J].中国病理生理杂志,2003,19(6):789.
38 Price DT,Schwinn DA,Lomasney jw,et al.Indentification,quantification and localization of mRNA for three distinct alpha_1 adrenergic recepter subtypes in human prostate[J].J Urol,1993:150:546-551.
39 刘紫庭,廖海球,杨菊云,等.川参通直接注入前列腺治疗慢性非细菌性前列腺炎,/慢性盆腔疼痛综合征[J].中华男科学,2005,11(9):705-707.
1 胡小朋,白文俊,朱积川,等.慢性前列腺炎细菌及免疫学研究[J].中华泌尿外科杂志,2002,23:29-31.
2 ROWE E,SMITH C,LAVERICK L,et al.A prospective,randomized,placebo controlled,double-blind study of pelvic electromagnetic therapy for the treatment of chronic pelvic pain syndrome with 1 year of followup[J].J Urol,2005,173:2044-2047.
3 PONTARI MA,MCNAUGHTON-COLLINS M,O'LEARY MP,et al.The CPCRN Study Group.A case-control study of risk factors in men with chronic pelvic pain syndrome[J].BJU Int,2005,96:559-565.
4 PAVONE C,CALDARERA E,LIBERTI P,et al.Correlation between chronic prostatitis syndrome and pelvic venous disease:a survey of 2,554 urologic outpatients[J].Eur Urol,2000,34:400-403.
5 陈勇,宋波,熊恩庆,等.前列腺与会阴盆底联系的电刺激研究[J].中华泌尿外科杂志,2004.25:124-126.
6 李兰群,王传航,刘春英.慢性前列腺炎中医证型分布频率研究[J].中华中医药杂志,2005,4:245-246.
7 陈志强,谭志健,桂泽红.604例慢性前列腺炎患者的中医辨证分型调查分析[J].广东中医药大学学报,1997,1:23-24.
8 Collins MM,Stafford RS,O' Leary MP,et al.Distinguishing chronic prostatitis and benign prostatic hyperplasia symptoms:results of a national survey of physician visits[J].Urology,1999,53:921-925.
9 陈志强,吴清和,王树声.前列清抑菌、抗炎和改善微循环作用的实验研究[J].广州中医大学报,2000,17(2):147-151.
10 许涛,戴宁,江安红.男炎消对大鼠实验性前列腺炎影响的病理学观察[J].安徽中医学报,2001,20(1):38-39.
11 贾金铭,张亚强.川参通注射液治疗前列腺增生症2009例临床疗效观察[J].中药新药与临床药理,2002,13(4):206-207.
12 吴金虎,王刚,张晓燕,等.前愈汤对慢性前列腺炎局部免疫功能影响的实验研究[J].湖北中医杂志,2006,28(3):11-12.
13 Alexander RB.Ponniah S,Hasday J,et al.Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis / chronic pelvic pain syndrome[J].Urology,1998,52:744-749.
14 Powell SM,Chfistiaens V,Voulgaraki D,et al.Mechanism of androgen receptor signalling via steroid receptor coactivator-1 in prostate[J].Endocr Relat Cancer,2004,11:117-130.
15 郭凯,王峥屹,杨磊林.四黄前列片对慢性前列腺炎模型大鼠前列腺组织中IL-1β和TNF-α含量的影响[J].中成药,2006,28(7):1042-1044.
16 陆新良,钱可大.丹参抗纤维化作用机制的研究进展[J].中华内科杂志,2006,45:608-610.
17 韩波.白细胞介素Ⅱ在慢性前列腺炎辅助诊断上的应用[J].辽宁中医杂志,2002,29:410.
18 薛慈民,朱琦,徐兆东.炎列平冲剂对慢性非细菌性前列腺炎实验小鼠的影响观察[J].中华男科学杂志,2003,9:312-315.
19 蒋毅,王久源.中药前必治治疗慢性前列腺炎的临床研究[J].中国中医基础医学杂志,1999,6(1):14-16.
20 周任远,张燕宾,马凤宁,等.不同类型慢性前列腺炎前列腺液锌含量的分布及意义[J].临床泌尿外科杂志,2004,19:168-169.
21 张蜀武,常德贵,王久源.通关胶囊对离体人增生前列腺α1-AR的拮抗作用[J].中华男科学,2001,7(2):136-138.
22 陈跃来,中鹏飞,陈国美,等.电针"会阳"、"中膂俞"对非细菌性前列腺炎大鼠尿流动力学影响的实验研究[J].针刺研究,2001,26:127-130.
2 马汉彬,陈复纯,肖广潮.慢性前列腺炎患者的尿动力学检查[J].河北医学,2006,16(3):205-207.
3 Bahk JY,Hyun Js,Lee JY.Concentration of ofloxacin in canine Prostate tissue and Prostate fluid after intraptos ratic iniecrion of biode-gradable sustained-releasing microspheres containing oflosacin[J].J Urol,2000,163(5):1560-1564.
4 中华医学会泌尿外科学分会.中国前列腺炎诊断治疗指南[M].中华医学信息导报,2006,19.
5 中国中西医结合学会男科专业委员会.慢性前列腺炎中西医结合诊疗指南[J].中国中西医结合杂志,2007,27(11):1052-1056.
6 贾金铭,薛慈民.前列安栓治疗慢性前列腺炎的疗效和安全性[J].中华男科,2001,7(6):417-419.
7 梁朝朝,张学军,王克孝.前列腺炎病因学研究进展[J].中华泌尿外科杂志,2003,6:26-28.
8 Krieger JNK,Riley DE.Bacteria in the chronic prostatitis-chronic pelvic pain syndrome:molecular approaches to critical research questions[J].JUrol,2002,167(6):2574-2583.
9 郭应禄,李宏军.前列腺炎[M].北京:人民军医出版社.2002.99-121.
10 Collins MM,Stafford RS,O' Leary MP,et al.Distinguishing chronic prostatitis and benign prostatic hyperplasia symptoms:results of a national survey of physician visits[J].Urology,1999,53:921-925.
11 鲍镇美.前列腺尿液返流与前列腺炎[J].中华泌尿外科杂志,1995,16(6):380.
12 何乐叶.前列腺炎综合征[J].中华泌尿外科杂志,1998,21(6):288-289.
13 Barbalias GA.Clinical and theraputical guidelines for chronic prostatitis[J].Eur Urol,2000,37(1).116-117.
14 吴荣佩,郑克立,胡红星,等.α_1 受体阻滞药治疗慢性前列腺炎疗效观察[J].临床泌尿外科杂志,2001,16(5):207-208.
15 顾方六.现代前列腺病学[M].北京:人民军医出版社,2002:541.
16 秦云峰.对中医“男胞”—前列腺生理功能再认识[J].中华男科学,2003,9(1):76-78.
17 张敏建.前列腺痛的中西医结合防与治[J].中国中西医结合杂志.2002,22(3):219.
18 高兆旺,宋景贵,张丽.论精室瘀阻是慢性前列腺炎的主要病机[J].山东中医药大学学报,2001,25(5),335-337.
19 高学敏.中药学[M].北京:中国中医药出版社,2004,2.
20 颜鸿,安国术.川参通注射液治疗慢性前列腺炎临床疗效观察(附342例治疗报告)[J].临床医药实践杂志,2008,17(9):743-744.
21 Lummus WE,Thompson I.Prostatitis[J].Emerg Ned Clin North Am,2001,19(3):691- 707.
22 梁宏,邓春华,李伟明,等.尿道前列腺返流显像及其在慢性前列腺炎中的应用[J].中华核医学杂志,1999,19(2):98-99.
23 Schaeffer AJ.National Institutes of Health Chronic Prostatitis Symptom Indexfor Japanese men[J].J Urol,2003,169(4):1616.
24 Cho L R,Keener T S,Nghiem H V,et al.Prostate blood flow characteristics in the chronic prastatitis/pelvic pain syndrome[J].Urol,2000,163:1130-1133.
25 Mehik A,Hellstrom P,Lukkarijen O,et al.Increased intraprostatic pressure in patients with chronic prostatitis[J].Urol Rest,1999,27:277-279.
26 沈柏华,金晓东,蔡松良,等.α_1受体阻滞剂联合抗生素治疗慢性前列腺炎疗效及机制[J].中华男科学杂志,2004,10(7):518-520.
27 许明,张永康,邹秋锋.慢性非细菌性前列腺炎尿流动力学改变及其对α_1受体阻断剂的反应[J].中国临床医学2002,9(4):371-373.
28 Nickel JC,Alexander RB,Schaeffer AJ,et al.Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls[J].J Urol,2003,170(3):818-822.
29 吴阶平.吴阶平泌尿外科学[M].山东科学技术出版社,2005,2.
30 吴洪涛,刘紫庭,杨罗艳.川参通对大鼠前列腺组织影响的实验研究[J].中国临床康复,2005,9(2):188-190.
31 王洁,张均田.总丹酚酸抗脑缺血与抗血栓的关系[J].中国药理学通报,1999.15(3):237-239.
32 陈进红.川芎素低分子右旋糖酐治疗急性脑梗死的对照研究[J].中国中西医结合杂志.1992,12(2):72.
33 李玉吉.全髋关节置换术后下肢深静脉血栓形成的治疗过程中D-二聚体的变化[J].中华实用中西医杂志.2006,19(5):558-559.
34 巫少荣,李自成,裘汉璋.当归在心血管系统的作用[J].中医药研究,2001,17(3):56-58.
35 谢可鸣,居颂光,顾永平,等.当归对体内外血吸虫卵肉芽肿反应抑制作用的实验研究[J].中国病理生理杂志,2002;18(9):1122-1125.
36 袁新初,张端莲.当归注射液对更年期大鼠超氧化物歧化酶和脂质过氧化物的影响[J].中草药,2001:32(9):822-823.
37 张旭,张超英,王文,等.麦冬药物血清对血管内皮细胞凋亡相父基因表达及胞内ca~(2+) 的影响[J].中国病理生理杂志,2003,19(6):789.
38 Price DT,Schwinn DA,Lomasney jw,et al.Indentification,quantification and localization of mRNA for three distinct alpha_1 adrenergic recepter subtypes in human prostate[J].J Urol,1993:150:546-551.
39 刘紫庭,廖海球,杨菊云,等.川参通直接注入前列腺治疗慢性非细菌性前列腺炎,/慢性盆腔疼痛综合征[J].中华男科学,2005,11(9):705-707.
1 胡小朋,白文俊,朱积川,等.慢性前列腺炎细菌及免疫学研究[J].中华泌尿外科杂志,2002,23:29-31.
2 ROWE E,SMITH C,LAVERICK L,et al.A prospective,randomized,placebo controlled,double-blind study of pelvic electromagnetic therapy for the treatment of chronic pelvic pain syndrome with 1 year of followup[J].J Urol,2005,173:2044-2047.
3 PONTARI MA,MCNAUGHTON-COLLINS M,O'LEARY MP,et al.The CPCRN Study Group.A case-control study of risk factors in men with chronic pelvic pain syndrome[J].BJU Int,2005,96:559-565.
4 PAVONE C,CALDARERA E,LIBERTI P,et al.Correlation between chronic prostatitis syndrome and pelvic venous disease:a survey of 2,554 urologic outpatients[J].Eur Urol,2000,34:400-403.
5 陈勇,宋波,熊恩庆,等.前列腺与会阴盆底联系的电刺激研究[J].中华泌尿外科杂志,2004.25:124-126.
6 李兰群,王传航,刘春英.慢性前列腺炎中医证型分布频率研究[J].中华中医药杂志,2005,4:245-246.
7 陈志强,谭志健,桂泽红.604例慢性前列腺炎患者的中医辨证分型调查分析[J].广东中医药大学学报,1997,1:23-24.
8 Collins MM,Stafford RS,O' Leary MP,et al.Distinguishing chronic prostatitis and benign prostatic hyperplasia symptoms:results of a national survey of physician visits[J].Urology,1999,53:921-925.
9 陈志强,吴清和,王树声.前列清抑菌、抗炎和改善微循环作用的实验研究[J].广州中医大学报,2000,17(2):147-151.
10 许涛,戴宁,江安红.男炎消对大鼠实验性前列腺炎影响的病理学观察[J].安徽中医学报,2001,20(1):38-39.
11 贾金铭,张亚强.川参通注射液治疗前列腺增生症2009例临床疗效观察[J].中药新药与临床药理,2002,13(4):206-207.
12 吴金虎,王刚,张晓燕,等.前愈汤对慢性前列腺炎局部免疫功能影响的实验研究[J].湖北中医杂志,2006,28(3):11-12.
13 Alexander RB.Ponniah S,Hasday J,et al.Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis / chronic pelvic pain syndrome[J].Urology,1998,52:744-749.
14 Powell SM,Chfistiaens V,Voulgaraki D,et al.Mechanism of androgen receptor signalling via steroid receptor coactivator-1 in prostate[J].Endocr Relat Cancer,2004,11:117-130.
15 郭凯,王峥屹,杨磊林.四黄前列片对慢性前列腺炎模型大鼠前列腺组织中IL-1β和TNF-α含量的影响[J].中成药,2006,28(7):1042-1044.
16 陆新良,钱可大.丹参抗纤维化作用机制的研究进展[J].中华内科杂志,2006,45:608-610.
17 韩波.白细胞介素Ⅱ在慢性前列腺炎辅助诊断上的应用[J].辽宁中医杂志,2002,29:410.
18 薛慈民,朱琦,徐兆东.炎列平冲剂对慢性非细菌性前列腺炎实验小鼠的影响观察[J].中华男科学杂志,2003,9:312-315.
19 蒋毅,王久源.中药前必治治疗慢性前列腺炎的临床研究[J].中国中医基础医学杂志,1999,6(1):14-16.
20 周任远,张燕宾,马凤宁,等.不同类型慢性前列腺炎前列腺液锌含量的分布及意义[J].临床泌尿外科杂志,2004,19:168-169.
21 张蜀武,常德贵,王久源.通关胶囊对离体人增生前列腺α1-AR的拮抗作用[J].中华男科学,2001,7(2):136-138.
22 陈跃来,中鹏飞,陈国美,等.电针"会阳"、"中膂俞"对非细菌性前列腺炎大鼠尿流动力学影响的实验研究[J].针刺研究,2001,26:127-130.