中西医结合治疗糖尿病肾病的临床研究
|
摘要
目的
对金匮肾气丸合水陆二仙丹联合西药治疗糖尿病肾病临床肾病期的疗效及安全性进行临床研究。通过与单纯西药治疗作对比观察,客观评价金匮肾气丸合水陆二仙丹治疗糖尿病肾病临床肾病期的疗效,进一步检测本方药的安全性,为临床用药提供科学依据。
方法
选取64例糖尿病肾病临床肾病期患者,均为我院2006年2月-2008年2月门诊、住院患者,中医辨证属脾肾气虚、脾肾阳虚证。采用随机、平行对照的原则分为对照组(32例)、实验组(32例)。两组患者治疗前年龄、性别、病程、主要中医症状等比较均无显著性差异,两组具有可比性。两组患者均给予糖尿病健康教育,控制饮食、适当运动,并予优质低蛋白饮食(0.6g/kg.d),对照组采用西药治疗:即用缬沙坦(代文)控制血压,格列喹酮(糖适平)控制血糖,氟伐他汀(来适可)调血脂;实验组:在对照组基础上,加用中药辨证施治,对脾肾气虚证型予金匮肾气丸合水陆二仙丹加党参、白术、黄芪,对脾肾阳虚证型予金匮肾气丸合水陆二仙丹加干姜、杜仲、仙灵脾,对有瘀血症状患者,可加用丹参、红花、益母草等活血化淤药。中药水煎服,每日一剂,分两次服,200ml/次,30天为1个疗程。
观察指标及方法:观察治疗前后主要临床症状、体证,记录不良反应,填写临床观察表。治疗前、一疗程结束后查24小时尿蛋白、血肌酐、尿素氮、空腹血糖、餐后2小时血糖,治疗前及用药结束后查血常规、粪常规、肝功能。
统计学处理:全部数据采用SPSS 13.0版本进行分析,显著水平取α=0.05。所有统计检验均采用双侧检验,P＜0.05表示所检验的差别有统计学意义;P＞0.05表示所检验的差别无统计学意义。计量资料采用t检验,计数资料采用X~2检验。
结果
1.对照组治疗临床肾病期在减少蛋白尿方面,显效11例,有效13例,无效8例,总有效率75.00%;实验组显效11例,有效14例,无效7例,总有效率78.13%,经统计学处理,两组间总疗效有显著差异(P＜0.05)。
2.相关中医症状总积分比较,同组内治疗后与治疗前比较有显著性差异(P＜0.05),两组治疗后中医症状积分均明显减少。一疗程结束后两组间中医症状积分比较有显著性差异(P＜0.05),实验组明显少于对照组。
3.在相关中医症状改善上,两组患者的相关中医症状在治疗后均较治疗前有显著改善(P＜0.05)。一疗程结束后,实验组在改善倦怠乏力、腰膝酸软、浮肿等方面明显优于对照组(P＜0.05)。
4.治疗前后,两组患者的血糖均有改善,两组间比较无显著差异(P＞0.05)。
5.安全性检测:经安全性检测,本方药对患者的血常规、粪常规、肝功能等均无不良影响,治疗前有异常的,治疗后无加重。在临床应用中所有患者均未发生不良反应及过敏现象。
结论
金匮肾气丸合水陆二仙丹联合西药治疗糖尿病肾病临床肾病期,可改善肾功能、减少蛋白尿,能明显改善夜尿频多、倦怠乏力、腰膝酸软、手足畏寒、浮肿等中医症状,并且使用安全,无毒副作用,说明金匮肾气丸合水陆二仙丹治疗糖尿病肾病临床肾病期有一定疗效,值得进一步研究及推广。
Objective
To study the clinical effect and safety of Jin Kui Shen Qi Wan and Shui Lu Er Xian Dan curing Diabetes Nephrosis clinical nephrosis time .To appraise the clinical curative effect and measure the security of Jin Kui Shen Qi Wan and Shui Lu ErXian Dan by comparing with western medicine, All the conclusion is to be offered scientific basis for clinical application.
Methods
64cases patients came from Hu Bei College of Traditional Chinese Medicine in February, 2006 - February, 2008 who are diagnosed as Qi Deficiency of Spleen and Kidney,Yang Deficiency of Spleen and Kidney. 64cases patients are divided into the control group (32 examples)and the treatment group (32 examples)in stochastical, parallel and comparison principle. Before two groups of patients accepting treatment, the age, the sex, the course, the main Chinese medicine symptom and so on quite even have no the significance differences, two groups have the commeasurability. Patients in two groups accept the diabetes health education, the control diet, the suitable movement, and the high quality low protein diet (0.6g/kg.d), the control group accept the western medicine treatment: Diovan is given to control the blood pressure ,Ge Lie Kui Tong is given to control the blood glucose ,the Fluvastatin is used to to be to adjust the blood fats. Treatment group: on the base of the control group, patients acceptthe traditional Chinese medicine dialectical treatment with Jin Kui Shen Qi Wan and Shui Lu ErXian Dan.Moreover, patients who are diagnosed as Yang Deficiency of Spleen and Kidney are given to Dang Shen ,BaiZhu,Huang Qi.Patients who are diagnosed as Yang Deficiency of Spleen and Kidney are given to Gan Jiang,Du Zhong,Xian Ling Pi. Patients with blood stasis could be given to herbal with activating blood and resolving stasis such as Dan Shen ,Hong Hua,Yi Mu Cao.Cook herbal with water.Patients in treat group take herbal decoction 200ml every time and twice one day.One treatment period is 30 days for each group.
Observation target and method: Observe the main clinical symptoms around observation treatment, fill in clinical observation table.Exame 24 hours urine protein、blood urea nitrogen、serum creatinine、fastingblood glucose、blood glucose 2 hours after meal、bloodroutine, stoolroutine.
Statistics processing: The complete data uses SPSS for the Windows13.0 edition to carry on the analysis, the remarkable level takesα=0.05. All statistical test uses the two-sided test, P<0.05 means that there is statistics significance in the differences examined; P>0.05 examines means that there is non-statistics significance in the differences examined. T-test is used in the measurement material, chi-square test is used in the counting material.
Result
1. The control group : 11 examples are distinctive , 13 examples are effective, 8 examples are invalid in reducing 24 hours urine protein and improving kidney function, the total effective rate is 75.00%. The treatment group: 11 examples are distinctive, 14 examples are effective, 7 examples are invalid, the total effective rate is 78.13%.There are distinctive differences between two groups by statistics processing(P<0.05).
2. The accumulative mark of both groups decreases after treatment in the related Chinese medicine symptoms. there are distinctive differences between two groups on the accumulative mark in the related Chinese medicine symptoms after treatment(P<0.05).
3. The related Chinese medicine symptoms of both groups are improved after treatment.The improvement of the treatment group on symptoms of fatigue、lumbar and knee soreness、edema is more distinctive(P<0.05).
4. After a treatment ,the blood glucose of two groups is controlled, but there is no distinctive differences between tow groups (P>0.05).
5. Safety inspection:There is not abnormal change in bloodroutine、stoolroutine after one treatment . There is no untoward effect or anaphylactic phenomenon in the clinical practice.It means that Jin Kui Shen Qi Wan and ShuiLu Er Xian Dan is safe and effective.
Conclusion
Jin Kui Shen Qi Wan and ShuiLu Er Xian Dan with western medicine to treat diabetes nephrosis clinical nephrosis time can improve the kidney function and reduce 24 hours urine protein、improve some Chinese medicine symptoms such as fatigue、lumbar and knee soreness、edema.Furthermore,it is safe and effective.All these indicate that it is worth to study and promote.
对金匮肾气丸合水陆二仙丹联合西药治疗糖尿病肾病临床肾病期的疗效及安全性进行临床研究。通过与单纯西药治疗作对比观察,客观评价金匮肾气丸合水陆二仙丹治疗糖尿病肾病临床肾病期的疗效,进一步检测本方药的安全性,为临床用药提供科学依据。
方法
选取64例糖尿病肾病临床肾病期患者,均为我院2006年2月-2008年2月门诊、住院患者,中医辨证属脾肾气虚、脾肾阳虚证。采用随机、平行对照的原则分为对照组(32例)、实验组(32例)。两组患者治疗前年龄、性别、病程、主要中医症状等比较均无显著性差异,两组具有可比性。两组患者均给予糖尿病健康教育,控制饮食、适当运动,并予优质低蛋白饮食(0.6g/kg.d),对照组采用西药治疗:即用缬沙坦(代文)控制血压,格列喹酮(糖适平)控制血糖,氟伐他汀(来适可)调血脂;实验组:在对照组基础上,加用中药辨证施治,对脾肾气虚证型予金匮肾气丸合水陆二仙丹加党参、白术、黄芪,对脾肾阳虚证型予金匮肾气丸合水陆二仙丹加干姜、杜仲、仙灵脾,对有瘀血症状患者,可加用丹参、红花、益母草等活血化淤药。中药水煎服,每日一剂,分两次服,200ml/次,30天为1个疗程。
观察指标及方法:观察治疗前后主要临床症状、体证,记录不良反应,填写临床观察表。治疗前、一疗程结束后查24小时尿蛋白、血肌酐、尿素氮、空腹血糖、餐后2小时血糖,治疗前及用药结束后查血常规、粪常规、肝功能。
统计学处理:全部数据采用SPSS 13.0版本进行分析,显著水平取α=0.05。所有统计检验均采用双侧检验,P＜0.05表示所检验的差别有统计学意义;P＞0.05表示所检验的差别无统计学意义。计量资料采用t检验,计数资料采用X~2检验。
结果
1.对照组治疗临床肾病期在减少蛋白尿方面,显效11例,有效13例,无效8例,总有效率75.00%;实验组显效11例,有效14例,无效7例,总有效率78.13%,经统计学处理,两组间总疗效有显著差异(P＜0.05)。
2.相关中医症状总积分比较,同组内治疗后与治疗前比较有显著性差异(P＜0.05),两组治疗后中医症状积分均明显减少。一疗程结束后两组间中医症状积分比较有显著性差异(P＜0.05),实验组明显少于对照组。
3.在相关中医症状改善上,两组患者的相关中医症状在治疗后均较治疗前有显著改善(P＜0.05)。一疗程结束后,实验组在改善倦怠乏力、腰膝酸软、浮肿等方面明显优于对照组(P＜0.05)。
4.治疗前后,两组患者的血糖均有改善,两组间比较无显著差异(P＞0.05)。
5.安全性检测:经安全性检测,本方药对患者的血常规、粪常规、肝功能等均无不良影响,治疗前有异常的,治疗后无加重。在临床应用中所有患者均未发生不良反应及过敏现象。
结论
金匮肾气丸合水陆二仙丹联合西药治疗糖尿病肾病临床肾病期,可改善肾功能、减少蛋白尿,能明显改善夜尿频多、倦怠乏力、腰膝酸软、手足畏寒、浮肿等中医症状,并且使用安全,无毒副作用,说明金匮肾气丸合水陆二仙丹治疗糖尿病肾病临床肾病期有一定疗效,值得进一步研究及推广。
Objective
To study the clinical effect and safety of Jin Kui Shen Qi Wan and Shui Lu Er Xian Dan curing Diabetes Nephrosis clinical nephrosis time .To appraise the clinical curative effect and measure the security of Jin Kui Shen Qi Wan and Shui Lu ErXian Dan by comparing with western medicine, All the conclusion is to be offered scientific basis for clinical application.
Methods
64cases patients came from Hu Bei College of Traditional Chinese Medicine in February, 2006 - February, 2008 who are diagnosed as Qi Deficiency of Spleen and Kidney,Yang Deficiency of Spleen and Kidney. 64cases patients are divided into the control group (32 examples)and the treatment group (32 examples)in stochastical, parallel and comparison principle. Before two groups of patients accepting treatment, the age, the sex, the course, the main Chinese medicine symptom and so on quite even have no the significance differences, two groups have the commeasurability. Patients in two groups accept the diabetes health education, the control diet, the suitable movement, and the high quality low protein diet (0.6g/kg.d), the control group accept the western medicine treatment: Diovan is given to control the blood pressure ,Ge Lie Kui Tong is given to control the blood glucose ,the Fluvastatin is used to to be to adjust the blood fats. Treatment group: on the base of the control group, patients acceptthe traditional Chinese medicine dialectical treatment with Jin Kui Shen Qi Wan and Shui Lu ErXian Dan.Moreover, patients who are diagnosed as Yang Deficiency of Spleen and Kidney are given to Dang Shen ,BaiZhu,Huang Qi.Patients who are diagnosed as Yang Deficiency of Spleen and Kidney are given to Gan Jiang,Du Zhong,Xian Ling Pi. Patients with blood stasis could be given to herbal with activating blood and resolving stasis such as Dan Shen ,Hong Hua,Yi Mu Cao.Cook herbal with water.Patients in treat group take herbal decoction 200ml every time and twice one day.One treatment period is 30 days for each group.
Observation target and method: Observe the main clinical symptoms around observation treatment, fill in clinical observation table.Exame 24 hours urine protein、blood urea nitrogen、serum creatinine、fastingblood glucose、blood glucose 2 hours after meal、bloodroutine, stoolroutine.
Statistics processing: The complete data uses SPSS for the Windows13.0 edition to carry on the analysis, the remarkable level takesα=0.05. All statistical test uses the two-sided test, P<0.05 means that there is statistics significance in the differences examined; P>0.05 examines means that there is non-statistics significance in the differences examined. T-test is used in the measurement material, chi-square test is used in the counting material.
Result
1. The control group : 11 examples are distinctive , 13 examples are effective, 8 examples are invalid in reducing 24 hours urine protein and improving kidney function, the total effective rate is 75.00%. The treatment group: 11 examples are distinctive, 14 examples are effective, 7 examples are invalid, the total effective rate is 78.13%.There are distinctive differences between two groups by statistics processing(P<0.05).
2. The accumulative mark of both groups decreases after treatment in the related Chinese medicine symptoms. there are distinctive differences between two groups on the accumulative mark in the related Chinese medicine symptoms after treatment(P<0.05).
3. The related Chinese medicine symptoms of both groups are improved after treatment.The improvement of the treatment group on symptoms of fatigue、lumbar and knee soreness、edema is more distinctive(P<0.05).
4. After a treatment ,the blood glucose of two groups is controlled, but there is no distinctive differences between tow groups (P>0.05).
5. Safety inspection:There is not abnormal change in bloodroutine、stoolroutine after one treatment . There is no untoward effect or anaphylactic phenomenon in the clinical practice.It means that Jin Kui Shen Qi Wan and ShuiLu Er Xian Dan is safe and effective.
Conclusion
Jin Kui Shen Qi Wan and ShuiLu Er Xian Dan with western medicine to treat diabetes nephrosis clinical nephrosis time can improve the kidney function and reduce 24 hours urine protein、improve some Chinese medicine symptoms such as fatigue、lumbar and knee soreness、edema.Furthermore,it is safe and effective.All these indicate that it is worth to study and promote.
引文
[1].mogensen CE.Early Diabetic Renal Involvement andNephropathy.In:Alberi KGmm,Krall Lp.The Diabetes hn-nual.Vol 3,Amsterdam,Elsevier Science Publishers,1987:306.
[2].郑法雷,章有康,陈香美等.肾脏病临床与进展[M].人民军医出版社,2006:88.
[3].张天,陈以平.实用中医肾病学[M].上海中医药大学出版社,1998:393.
[4].王海燕.肾脏病学[M].人民卫生出版社,第二版,952-955.
[5].郑法雷,章有康,陈香美等.肾脏病临床与进展[M].人民军医出版社,2006:84-91.
[6].陈燕铭,曾龙驿.糖尿病肾病的早期诊断与治疗[J].新医学,2002,33(4):234-235.
[7].段富津.方剂学.第六版[M].上海科学技术出版社,141.
[8].梅全喜,毕焕新.现代中药药理手册[M].中国中医药出版社,1998:525-560.
[9].李渊何.单味中药治疗糖尿病的研究进展[J].天津中医学院学报,2004,23(2):692-693.
[10].王本祥.现代中药药理与临床[M].天津:天津科技翻译出版公司,2004:53.
[11].张淑贞,程立方.降血糖、中药及方剂药理研究概况[J]中药研究,1996,(2):64.
[12].许兰芝等.淫洋藿总黄酮降压作用机理的研究.中医药学报,2002,30(4):57.
[13].蒋鹏,王春菊.中西医结合治疗慢性肾功能不全64例[J].实用中医药杂志,2002,18(11).
[14].雷载全.中药学.第六版[M].上海科学技术出版社,279.
[1].王子敏等.中西医临床肾病学[M].第1版,中国中医药出版社1997:217
[2].温化水.糖尿病肾病晚期的中医治疗[J].北京中医学院学报,1992,15(1):46-47.
[3].贾在金,孙静,张维霞等.糖肾气血汤辅助治疗临床期糖尿病肾病患者60例.中国中西医结合杂志,2003,23(7):542-543.
[4].张天.实用中医肾病学[M].第1版,上海中医学院出版社,1990:712-713.
[5].任爱华,阚方旭.糖尿病肾病三焦辨治[J].山东中医杂志,2000,19(6):328.
[6].李大均,范克.糖尿病肾病的中医辨证治疗[J].河北中医,2001,23(9):682-683.
[7].李磊,周健华,冯箐,等.糖肾停治疗糖尿病肾病[J].中医药信息,2000,(6):35-36.
[8].冯建春,倪青.糖肾胶囊治疗糖尿病肾病的临床研究.中国中西医结合杂志,2000,20(3):212-214.
[9].向少伟.中西医结合治疗糖尿病肾病临床观察.广州中医药大学学报,2005,22(I)16.
[10].林丽梅.中西医结合治疗糖尿病肾病36例临床观察.临床试验医学杂志2007,6(1):147.
[11].王淑花等.中西医结合治疗糖尿病肾病的临床研究[J].中国全科医学,2005,8(24):2065.
[12].赵进喜,于秀辰,王世东等.中西医结合治疗糖尿病肾病肾功能不全失代偿期临床分析[J].中医药学刊,2005,23(3):440-442.
[13].刘伟,贝岩.中医药治疗糖尿病肾病70例[J].辽宁中医杂志,2005,31(1):41.
[14].吕贵德.辨证论治糖尿病肾病38例疗效观察[J].河北中医2002,103.
[15].徐延,徐京育.中西医结合治疗糖尿病肾病33例[J].四川中医,2002,20(6):3839.
[16].邓经林.48例糖尿病肾病的中医辨治[J].江西中医药2001.(29)
[17].王亚敏.中西医结合治疗临床期糖尿病肾病疗效观察[J].中国中西医结合肾 病杂志,2002,3(4):232-234.
[18].王敏,曹蕾.中西医结合治疗糖尿病肾病37例[J].实用中医药杂志,2002,18(9):24.
[19].陈辉崇,刘柏炎.加味地黄汤治疗早期糖尿病肾病32例[J].湖南中医杂志,2004,20(2):36-37.
[20].魏宏峰、张震雷.补肾活血祛瘀法治疗糖尿病肾病34例[J].实用中医内科杂志2005.158.
[21].陈培智,陈绍辉,李树浩等.中西医结合治疗糖尿病肾病临床观察[J].中国中西医结合肾病杂志,2002,3(3):145-148.
[22].赵怡蕊、刘光珍、宋跃飞、韩履棋.芪术汤治疗糖尿病肾病的疗效观察[J].中国中西医结合肾病杂志.2006:230.
[23].刘迅,范培金.中西医结合治疗糖尿病肾病46例近期临床疗效[J].中国中西医结合肾病杂志,2003,4(3):173-174.
[24].林溢涛、谭嫂娜、张健池补阳还五汤治疗糖尿病肾病35例疗效观察[J].新中医.2006.29.
[25].林兰,郭力.糖微康对糖尿病肾病患者血液流变学的影响.中国中西医结合肾病杂志,2003,4(4):215-217.
[26].陈少华,侯风英.张连记黄芪注射液治疗糖尿病肾病疗效观察[J].中成药,2000,22(3):207-209.
[27].张继红.黄芪注射液治疗糖尿病肾病的研究[J].中国慢性病预防与控制,2000,8(4):188-189.
[28].王悦芳.黄芪注射液配合丹参注射液治疗糖尿病肾病的临床观察[J].临床荟萃,2002,17(21):1280-1281.
[29].杨益芳.葛根素注射液治疗50例糖尿病肾病的疗效观察[J].泸州医学院学报,2003,26(1):54-55.
[30].王慧芳,马骏,陈国庆等.大黄对早期糖尿病肾病患者肾脏血流动力的影响[J].铁道医学,2001,29(5):320.
[31].田云龙.血塞通注射液干预治疗糖尿病肾病的临床观察[J].中国中西医结合杂志,2002,22(10):753.
[32].占永力.中药三七注射液对显性糖尿病肾病并高凝状态的影响[J].中国中西医结合肾病杂志,2002,3(1):23.
[33].周兴磊,冯志刚,张本祥.冬虫夏草治疗糖尿病肾病90例临床分析[J].临床医学,2000,20(1):54-55.
[34].冯玉芳,张绍荣,任明芬等.川芎嗪治疗糖尿病肾病的近期疗效[J].临床荟萃,1999,14(2):77-78.
[35].朱家明,刘志红,李颖健等.大黄酸对葡萄糖转运蛋白基因转染系膜细胞功能的影响[J].中华内科杂志,2001,40(8):537-540.
[36].朱加明,刘志红,黄燕飞等.大黄酸对db/db小鼠糖尿病肾病疗效的观察[J].肾脏病与肾透析肾移植杂志,2002,11(1):3-5.
[37].元文波,陈凌,王兰芳等.黄芪对DM大鼠肾脏氧化糖基化影响的实验研究[J].泰山医学院学报,2001,22(3):190—193.
[38].陈健.氨基胍和维生素C调节自发糖尿病肾病基膜粘连蛋白基因表达的实验研究.陕西医学杂志2007,36(7):778.
[39].李强翔.葛根素调节糖尿病肾病大鼠降钙素相关肽的研究.中国微循环2007,11(1):33.
[40].马仁强.黄丹益肾胶囊对糖尿病肾病大鼠的防治作用实验研究.中成药2005,27(2):195.
[41].徐颖等.黄连总生物碱对实验性糖尿病肾病大鼠肾功能保护作用的研究.重庆医学2007,36(6):526.
[42].王光浩.黄芪注射液治疗糖尿病肾病的实验研究,微循环学杂志,2007,17(1):20-21.
[43].刘卿.六味地黄丸对糖尿病肾病大鼠肾脏保护作用的研究,湖南中医药大学学报2007,27(6):40.
[2].郑法雷,章有康,陈香美等.肾脏病临床与进展[M].人民军医出版社,2006:88.
[3].张天,陈以平.实用中医肾病学[M].上海中医药大学出版社,1998:393.
[4].王海燕.肾脏病学[M].人民卫生出版社,第二版,952-955.
[5].郑法雷,章有康,陈香美等.肾脏病临床与进展[M].人民军医出版社,2006:84-91.
[6].陈燕铭,曾龙驿.糖尿病肾病的早期诊断与治疗[J].新医学,2002,33(4):234-235.
[7].段富津.方剂学.第六版[M].上海科学技术出版社,141.
[8].梅全喜,毕焕新.现代中药药理手册[M].中国中医药出版社,1998:525-560.
[9].李渊何.单味中药治疗糖尿病的研究进展[J].天津中医学院学报,2004,23(2):692-693.
[10].王本祥.现代中药药理与临床[M].天津:天津科技翻译出版公司,2004:53.
[11].张淑贞,程立方.降血糖、中药及方剂药理研究概况[J]中药研究,1996,(2):64.
[12].许兰芝等.淫洋藿总黄酮降压作用机理的研究.中医药学报,2002,30(4):57.
[13].蒋鹏,王春菊.中西医结合治疗慢性肾功能不全64例[J].实用中医药杂志,2002,18(11).
[14].雷载全.中药学.第六版[M].上海科学技术出版社,279.
[1].王子敏等.中西医临床肾病学[M].第1版,中国中医药出版社1997:217
[2].温化水.糖尿病肾病晚期的中医治疗[J].北京中医学院学报,1992,15(1):46-47.
[3].贾在金,孙静,张维霞等.糖肾气血汤辅助治疗临床期糖尿病肾病患者60例.中国中西医结合杂志,2003,23(7):542-543.
[4].张天.实用中医肾病学[M].第1版,上海中医学院出版社,1990:712-713.
[5].任爱华,阚方旭.糖尿病肾病三焦辨治[J].山东中医杂志,2000,19(6):328.
[6].李大均,范克.糖尿病肾病的中医辨证治疗[J].河北中医,2001,23(9):682-683.
[7].李磊,周健华,冯箐,等.糖肾停治疗糖尿病肾病[J].中医药信息,2000,(6):35-36.
[8].冯建春,倪青.糖肾胶囊治疗糖尿病肾病的临床研究.中国中西医结合杂志,2000,20(3):212-214.
[9].向少伟.中西医结合治疗糖尿病肾病临床观察.广州中医药大学学报,2005,22(I)16.
[10].林丽梅.中西医结合治疗糖尿病肾病36例临床观察.临床试验医学杂志2007,6(1):147.
[11].王淑花等.中西医结合治疗糖尿病肾病的临床研究[J].中国全科医学,2005,8(24):2065.
[12].赵进喜,于秀辰,王世东等.中西医结合治疗糖尿病肾病肾功能不全失代偿期临床分析[J].中医药学刊,2005,23(3):440-442.
[13].刘伟,贝岩.中医药治疗糖尿病肾病70例[J].辽宁中医杂志,2005,31(1):41.
[14].吕贵德.辨证论治糖尿病肾病38例疗效观察[J].河北中医2002,103.
[15].徐延,徐京育.中西医结合治疗糖尿病肾病33例[J].四川中医,2002,20(6):3839.
[16].邓经林.48例糖尿病肾病的中医辨治[J].江西中医药2001.(29)
[17].王亚敏.中西医结合治疗临床期糖尿病肾病疗效观察[J].中国中西医结合肾 病杂志,2002,3(4):232-234.
[18].王敏,曹蕾.中西医结合治疗糖尿病肾病37例[J].实用中医药杂志,2002,18(9):24.
[19].陈辉崇,刘柏炎.加味地黄汤治疗早期糖尿病肾病32例[J].湖南中医杂志,2004,20(2):36-37.
[20].魏宏峰、张震雷.补肾活血祛瘀法治疗糖尿病肾病34例[J].实用中医内科杂志2005.158.
[21].陈培智,陈绍辉,李树浩等.中西医结合治疗糖尿病肾病临床观察[J].中国中西医结合肾病杂志,2002,3(3):145-148.
[22].赵怡蕊、刘光珍、宋跃飞、韩履棋.芪术汤治疗糖尿病肾病的疗效观察[J].中国中西医结合肾病杂志.2006:230.
[23].刘迅,范培金.中西医结合治疗糖尿病肾病46例近期临床疗效[J].中国中西医结合肾病杂志,2003,4(3):173-174.
[24].林溢涛、谭嫂娜、张健池补阳还五汤治疗糖尿病肾病35例疗效观察[J].新中医.2006.29.
[25].林兰,郭力.糖微康对糖尿病肾病患者血液流变学的影响.中国中西医结合肾病杂志,2003,4(4):215-217.
[26].陈少华,侯风英.张连记黄芪注射液治疗糖尿病肾病疗效观察[J].中成药,2000,22(3):207-209.
[27].张继红.黄芪注射液治疗糖尿病肾病的研究[J].中国慢性病预防与控制,2000,8(4):188-189.
[28].王悦芳.黄芪注射液配合丹参注射液治疗糖尿病肾病的临床观察[J].临床荟萃,2002,17(21):1280-1281.
[29].杨益芳.葛根素注射液治疗50例糖尿病肾病的疗效观察[J].泸州医学院学报,2003,26(1):54-55.
[30].王慧芳,马骏,陈国庆等.大黄对早期糖尿病肾病患者肾脏血流动力的影响[J].铁道医学,2001,29(5):320.
[31].田云龙.血塞通注射液干预治疗糖尿病肾病的临床观察[J].中国中西医结合杂志,2002,22(10):753.
[32].占永力.中药三七注射液对显性糖尿病肾病并高凝状态的影响[J].中国中西医结合肾病杂志,2002,3(1):23.
[33].周兴磊,冯志刚,张本祥.冬虫夏草治疗糖尿病肾病90例临床分析[J].临床医学,2000,20(1):54-55.
[34].冯玉芳,张绍荣,任明芬等.川芎嗪治疗糖尿病肾病的近期疗效[J].临床荟萃,1999,14(2):77-78.
[35].朱家明,刘志红,李颖健等.大黄酸对葡萄糖转运蛋白基因转染系膜细胞功能的影响[J].中华内科杂志,2001,40(8):537-540.
[36].朱加明,刘志红,黄燕飞等.大黄酸对db/db小鼠糖尿病肾病疗效的观察[J].肾脏病与肾透析肾移植杂志,2002,11(1):3-5.
[37].元文波,陈凌,王兰芳等.黄芪对DM大鼠肾脏氧化糖基化影响的实验研究[J].泰山医学院学报,2001,22(3):190—193.
[38].陈健.氨基胍和维生素C调节自发糖尿病肾病基膜粘连蛋白基因表达的实验研究.陕西医学杂志2007,36(7):778.
[39].李强翔.葛根素调节糖尿病肾病大鼠降钙素相关肽的研究.中国微循环2007,11(1):33.
[40].马仁强.黄丹益肾胶囊对糖尿病肾病大鼠的防治作用实验研究.中成药2005,27(2):195.
[41].徐颖等.黄连总生物碱对实验性糖尿病肾病大鼠肾功能保护作用的研究.重庆医学2007,36(6):526.
[42].王光浩.黄芪注射液治疗糖尿病肾病的实验研究,微循环学杂志,2007,17(1):20-21.
[43].刘卿.六味地黄丸对糖尿病肾病大鼠肾脏保护作用的研究,湖南中医药大学学报2007,27(6):40.