我国重大动物疫病区划研究
详细信息    本馆镜像全文|  推荐本文 |  |   获取CNKI官网全文
摘要
我国是世界上畜牧业大国,肉类总产量居世界第一,畜产品具有明显的价格优势。但我国肉类出口量仅占世界肉类出口总量的3.6%,动物疫病是影响着我国畜牧业持续发展和畜产品国际竞争力的主要因素之一。动物疫病区域化管理是国际上通行的动物疫病管理模式,世界上已有60多个国家和地区被OIE认可为无口蹄疫等重大动物疫病的国家和地区,这些国家和地区在畜产品国际贸易中得到了实惠。新修订的动物防疫法提出我国要实行动物疫病区域化管理,因此,从我国动物疫病发生和流行规律入手,研究动物疫病区划,对于确定无规定动物疫病区和指导动物疫病区域化管理具有重要的现实意义。
     本研究从动物疫病区划的角度出发,通过系统分析我国动物防疫工作现状的基础上,研究提出了动物疫病区划的方法体系。重点探讨了动物重大疫病区域划分和各区域重大动物疫病防控策略。在动物疫病区域化管理方面,研究了我国无规定动物疫病区建设的发展战略。
     首先,全面分析和总结了我国动物疫病流行特点、防疫体系建设情况和防疫技术措施发展情况。目前我国动物疫情还不断发生,重大动物疫病还未得到有效遏制,无规定动物疫病区还没有得到国际社会的认可。通过与发达国家比较,提出我国动物防疫工作还存在动物疫情应急反应机制不够完善、部分地区防疫技术手段比较落后、基层动物防疫机构不健全、贫困地区基层防疫队伍人员素质不高和动物防疫法律法规体系不够健全等问题。
     其次,较系统地研究了动物疫病区划的目标、原则、分类体系、区划方法及区划程序。动物疫病的发生和发展是自然因素和社会因素共同作用的产物,它呈现区域性特点,遵循自然分离规律。通过计算动物疫病流行指数对我国重大动物疫病进行了区划。重大动物疫病的流行区域分成五个等级,分别是洁净区、散发区、中度流行区、较重流行区和严重流行区。分析了各个区的地理分布和疫病流行特点。
     第三,研究提出了不同流行区重大动物疫病防制策略。洁净区是消灭重大动物疫病和建设无规定动物疫病区的首选区域,要严格采取扑杀措施防控和净化重大动物疫病;散发区动物疫病的防控策略是建立动物重大疫病隔离带,保证周边的动物疫情不传播到本区域内。同时,通过免疫等技术手段使散发区逐步转化为洁净区;中度流行区要适度发展畜牧业,严禁动物和畜禽产品外调和出口,控制疫病的发展和扩散;动物疫病较重区和严重区主要分布在我国的边界地区,国外疫病影响、经济落后、民族习惯和生活方式以及大都市的国际交流和人员往来是动物疫病发生的主要原因。这些地区的防疫工作要依靠国家来完成。
     第四,研究了口蹄疫、禽流感、猪瘟、新城疫和猪蓝耳病等五种重大动物疫病在我国的流行特点、区域分布,总结了国外防制经验和消灭净化方法,提出了我国消灭这五种动物疫病的思路和措施。
     最后,研究了我国无规定动物疫病区发展战略。主要战略措施是调整无规定动物疫病区域,鼓励大型养殖企业建设“生物安全小区”;转变无疫区畜禽饲养管理模式,提高畜禽规模化和集约化饲养程度;强无疫区动物疫病的监测能力,摸清疫病流行情况;建立和完善无规定动物疫病区追溯体系建设,强化区内动物及动物产品标识工作;积极推进我国无疫区的国际认证和认可工作。
     本文的主要政策建议有尽快制定和实施重大动物疫病扑灭计划、进一步加强重大动物疫病应急反应能力、不断深化兽医管理体制改革和完善国家兽医官制度、进一步完善无规定动物疫病区建设工作、制定和完善动物防疫法律法规等。
China is an important country for livestock industry with the largest meat production in the world. China’s animal products have obvious price competency, but the meat export only account for 3.6 percent of that in the world. Animal disease is one of key factors influencing the sustainable development of animal production and the international competency of animal products. Zoning management of animal diseases is the common management pattern of animal diseases all over the world. So far, more than 60 countries and regions have been identified as disease-free countries and regions by OIE, mainly including foot and mouth disease (FMD) and other major diseases. These countries and regions have been favored in the international trade of animal products. The new revised Animal epidemic prevention law of People's Republic of China proposed that the zoning management of animal disease should be implemented in China. Therefore, it has important and realistic significance to conduct a research on the zoning of animal disease by taking the understanding of the disease occurrence and epidemic law as a start point for identifying special animal disease free zone and guiding the regional management of animal disease.
     The methodology of animal disease zoning was put forward in this paper based on the systemic analysis of the current situation of animal disease control in China. The dividing of major animal disease zone and the control strategy in various zones were focused on a discussion. At the aspect of zoning management of animal disease, the development strategy of constructing special animal disease free zone was studied.
     Firstly, the epidemic situation of animal disease, the establishment of control system and the technological development of control measures were comprehensively analyzed and summarized. At present, the continuous occurrence of animal diseases in China show that major animal diseases have not been effectively controlled. The special animal disease free zone of China is not recognized by the international community. Based on the comparison with developed countries, the problems existed in animal diseases control were advanced including unimproved emergency response mechanism; lagged control means in selected regions; unimproved control institutions grassroots; lower quality of staff of animal diseases control in poverty-stricken area; as well as unsound regulatory system.
     Secondly, the objectives, principles, classification system, zoning methods and zoning procedures of animal diseases were systemically studied. The occurrence and evolution of animal disease is a product of common action by natural and social elements, which exhibit regional feature and comply for natural separation law. By calculating the epidemic index of animal diseases, zoning of major animal diseases was conducted. The epidemic zones were divided into five grades, i.e. clean zone, sporadic zone, moderate epidemic zone, heavy epidemic zone and serious epidemic zone. The geographic distribution and epidemic characteristics of various zones were analyzed.
     Thirdly, the control strategies of different epidemic zone were proposed. Clean zone is the area firstly selected for eliminating the diseases and constructing special disease free zone. Therefore, killing campaigns is chosen as control measure,and it must be strictly implemented. For the sporadic zone, the control strategy is establishing disease-isolated area to ensure that animal diseases around the zone don’t spread in the zone. Meanwhile, efforts should be made to change sporadic zone to clean zone by technological means such as vaccination. As for moderate epidemic zone, the export of animals and animal products should be strictly restricted as well as the availability in other regions so as to control the development and spreading of disease. In the heavy and serious epidemic zones which mainly distributed in boundary of China, the effect of foreign diseases, lagged economy, nationality and life style, international personnel exchange in big cities are the main reasons for the occurrence of animal diseases. The disease control in these zones should be undertaken by the country.
     Fourthly, the epidemic characteristics, regional distribution of five kinds of major animal diseases were studied, including foot and mouth disease (FMD), highly pathogenic avian influenza (HPAI), swine fever, Newcastle Disease (ND) and Porcine Reproductive and Respiratory Syndrome (PRRS). And based on summarizing the control experiences and elimination and cleaning methods in foreign countries, the thought way and measure were advanced to eliminate the above mentioned five diseases in China.
     At last, the development strategy of special animal disease free zone was studied. The main strategic measures advanced in this paper were as follows: i) to adjust the establishment of special animal disease free zone and encourage the large-scale breeding enterprises to construct the biological safety region; ii) to change the management mode of animal raising in disease free area to promote the degree of lager-scale and integrated production; iii) to enhance the capability of monitoring animal disease in disease free area to understand the epidemic situation; iv) to establish and improve the construction of tracing system in special disease free zone, and to strengthen the labeling of animal and animal products within the zone; v) to actively push forward the work of international certification and ratification.
     The policy recommendations advanced in the paper included: i) to formulate and implement the extermination plan of major animal diseases as soon as possible; ii) to further strengthen the emergency response capability; iii) to gradually deepen the reform of veterinary management system and improve the national veterinary officer system; iv) to further perfect the construction of special animal disease free zone; v) to formulate and improve the legislation on disease control.
引文
1. B.W.卡尔尼克主编.高福,苏敬良主译.禽病学(第10版).北京:中国农业大学出版社, 1999:691-726.
    2.中国农业科学院哈尔滨兽医研究所.动物传染病学.北京:中国农业出版社, 2008:547-553.
    3.中国动物防疫体系进一步完善建450个疫情测报监测站[J].中国动物检疫,2003,(5):9
    4.孔伟.公共管理的实践和理论背景[J].中国人民大学学报,2004,(2):110-1l4
    5.毛磊.非典和禽流感进一步暴露全球动物防疫体系缺陷[N].新华每日电讯,2004年
    6.王长彬,论无规定动物疫病区建设[J].四川畜牧兽医,2007,(5):18-19
    7.王作洲,孙公文.完善兽医管理体制网络建设扎紧基层动物卫生防疫篱笆[J].黑龙江畜牧兽医, 2005,(12)
    8.王忠昌,董兆斗.动物防疫体系存在的问题及建议[J].畜牧兽医科技信息,2005,(4):15
    9.王忠昌,董兆斗.动物防疫体系存在的问题及建议[J].畜牧兽医科技信息,2005,(4):15
    10.王铮,马翠芳.区域管理:管理学的新方向[J].科学对社会的影响,2001,(1):19-23
    11.北京加快构建动物防疫体系[J].中国牧业通讯,2005,(3):20
    12.卢金明,李一生,陈天学.宝山镇强化动物防疫体系[J].养殖技术顾问,2004,(4)
    13.卢金明,李一生,陈天学.宝山镇强化动物防疫体系[J].养殖技术顾问,2004,(4):45
    14.甘孟侯.《禽流感》(第二版).北京:中国农业大学出版社, 2002
    15.申保珍.完善动物防疫体系应建四大制度[N].农民日报,2004年
    16.农工党福建省委员会.加强动物防疫体系建设,促进畜牧业发展[N].人民政协报,2004年
    17.刘学剑.加强动物防疫体系建设的思考[J].动物保健,2005,(4):28
    18.刘环,李海清,佘锐平.动植物疫病区域化国际规则综述[J].世界农业, 2006(5)
    19.吕健,张建武,孙志,刘维全,袁世山.高致病性猪蓝耳病病毒感染性克隆的构建及应用.微生物与感染,2007,2(4):219-227.
    20.年福华,姚士谋,陈振光.试论城市群区域内的网络化组织[J].地理科学,2002,22(5):568-573
    21.庄跃民,张钦逊,潘志忠,张玉泉.惠安县动物防疫体系现状与建议[A];福建省科协第四届学术年会卫星会议“动物疫病防治与人类健康”学术年会论文集[C],2004年
    22.那玉林,李占宏.21世纪我国地理学发展的一个方向——区域管理学[J].阴山学刊,2000,15(4):14-15
    23.余勇,四川无规定动物疫病区建设的做法[J].兽医导刊,2007,(7):21-24
    24.张建军.山西动物防疫体系亟待强化[N].中国食品报,2005年
    25.张建武,庄金山,袁世山.中国部分地区“猪高热综合征”的病原学调查及高致病性猪繁殖与呼吸综合征病毒的分子流行病学研究.中国农业科学,2008, 41(6):1822-1831
    26.李玉锋,邓雨修,姜平,等.猪繁殖和呼吸综合征流行病学研究[C].//中国畜牧兽医学会家畜传染病学分会第11次学术研讨会论文集.中国畜牧兽医学会家畜传染病学分会,2005:197-200.
    27.李凯年,国外动物疫病传入途径、危害与控制[J].中国动物检疫,2007,(2):43-45
    28.李凯年.发达国家动物防疫体系值得借鉴[N].中国畜牧报,2004年
    29.李学辉,章昌炳.基层动物防疫队伍建设探析[J].中国牧业通讯,2004,(19)
    30.李建民.浅谈完善动物防疫体系的几点看法[J].青海畜牧兽医杂志,2001,(1):45
    31.李忠文.加强动物防疫体系建设[J].动物保健,2004,(6):7-8
    32.李忠文.动物防疫体系建设的探讨[J].中国牧业通讯,2004,(23):8-9
    33.李金永,王茂成,方德贵,贾英,张成辉,戚鹏,张海美.防疫体系建设是改革的关键[J].动物保健,2005,(7)
    34.李善同,刘勇.我国中央一地方权限划分与区域管理模式[J].经济研究参考,2002,(14):2-9
    35.杨艾青,宋之敏.武川县:构筑三级动物防疫体系[N].呼和浩特日报(汉),2004年
    36.邵锦香,杨自立,陈佳铭,郜志坤,杨再.关于建立国家动物防疫体系的建议[J].家畜生态学报,2004,(4):284-285,289
    37.邹普圣,宋荣荣,高财根,何秋生,钟尚杰.基层动物防疫体系建设迫待加强——新余市渝水区基层畜牧兽医体系建设情况调查[J].江西畜牧兽医杂志,2004,(6)
    38.单守林,吴锁柱.河北启动乡镇动物防疫体系改革[J].中国牧业通讯,2004,(1):11
    39.周建胜.关于完善我省动物防疫体系的调查[J].中国动物检疫,1999,(3):24-25
    40.周祖华.动物防疫体系何时能稳定[J].中国牧业通讯,2004,(17):79
    41.周祖华.动物防疫体系何时能稳定[J].中国牧业通讯,2004,(17):79
    42.武深树,谭美英.对动物防疫体系建设的思考[J].广东畜牧兽医科技,2005,(1):8-10
    43.范钦磊,美国动物疫病区域化评估认可的研究[J].中国动物检疫,2007,(4):36-38
    44.郑汉根.动物防疫体系欧盟2500多个防疫机构织成一张网[N].新华每日电讯,2004年
    45.姚建聪,李美花,方树河,朱连德,我国规模化猪场蓝耳病流行病学调查[J], 2006.05 SWINE INDUSTRY SCIENCE,23-24.
    46.施秋艳,徐东萍.乡镇畜牧兽医站体制改革探索[J].中国牧业通讯,2002,(9)
    47.柏云江,澳大利亚动物疫病控制体系对我国动物防疫工作的启示与建议[J].现代畜牧兽医,2007,(10):3-7
    48.夏珺.我国动物防疫体系日臻完善[N].人民日报,2003年
    49.徐成,刘文春.临沂地区畜牧兽医情况的调查与思考[J].山东畜牧兽医,1994,(4)
    50.殷震,刘景华.动物病毒学.北京:科学出版社, 1997:743-50.
    51.浦华,王济民,我国无规定动物疫病区建设的探讨[J].中国畜牧杂志,2007,(14):17-19
    52.秦荣香,吴志君,肖有恩,唐荣福,蒋志疆.猪场伪狂犬病的净化[A];中国猪业发展大会论文集[C], 2005年
    53.聂凤英.禽流感对我国禽类产品出口的影响[J].中国牧业通讯,2004,(4)
    54.郭宝清,陈章水,刘文兴等.从疑似PRRS流产胎儿分离猪生殖和呼吸综合征病毒(PRRSV)的研究.中国畜禽传染病,1996, 87(2):1-5.
    55.高玉平.建立与国际接轨的兽医防疫体系[J].中国牧业通讯,2004,(11)
    56.高伶慧,重大动物疫情长效预警机制的建立[J].中国动物保健,2007,(1):50-56
    57.高志强,郭鑫,陈艳红,查振林,杨汉春.猪繁殖与呼吸综合征病毒HB-1(sh)/2002株全基因组分子特征分析[J].病毒学报,2004,20(3):270-274.
    58.崔保安,王学兵.当前鸡新城疫发病与流行的新特点及防制对策.兽医导刊, 2009,145(9):27-29.
    59.曹繁礼,黄逊,薛华平.从新词“Compartmentalization”(区隔化)的引入看国际动物疫病区域化建设的发展趋势[J].特区国检, 2006,(1)
    60.喻存福,李迎慧,王晓凤,杨宝成.动物防疫工作面临的形势及对策[J].黑龙江畜牧兽医,2003,(5)
    61.韩西坤.动物防疫体系建设的困惑[J].中国动物检疫,2004,(12):26-27
    62.雷先才.加强动物防疫体系建设的几点建议[J].中国牧业通讯,2004,(13):72
    63.雷先才.加强动物防疫体系建设的几点建议[J].中国牧业通讯,2004,(13):72
    64.谭美英,武深树.加强动物防疫体系建设的基本原则[J].动物保健,2005,(6):24-25
    65.薛领,杨开忠.复杂性科学理论与区域空间演化模拟研究[J].地理研究,2002,21(1):79-88
    66.魏荣,黄保续,倪雪霞.国际动物卫生组织重要标准的修订动态[J].中国动物检疫, 2006,(2)
    67. A short history of Animal Health Economics. T. F. Randolph. H. W. Saatkamp, and B. D. Perry. Proceedings of 10th international symposium for veterinary epidemiology and economics. Chile, 2003
    68. A. Dijkhnizen.R.S. Morris. Animal Health Economics, Post Graduate Foundation in Veterinary Science University of Sydney
    69. A. Dijkhuizen. R.S. Morris. Animal health economies-principles and applications. New Zealand: Post Graduate Foundation in Veterinary Science, 1997,187 -199
    70. Aalt A. Dijkhuizen, Roger S. Morris. 1997, Animal Health Economics-Principles and Applications, Post Graduate Foundation in Veterinary Science, New Zealand, pp. 187 -199
    71. Alexander D J. Newcastle Disease. Kluwer Academic Publishers, Boston, MA, 1988,1-10
    72. Allsep S, Gosney M, Haycox A, Regan M. Cost-benefit evaluation of routine influenza munization in people 65 -74 years of age. Health technology Assessment. 2003, 7 (24): 1-92
    73. An, T.Q., Zhou, Y.J., Liu, G.Q., Tian, Z.J., Li, J., Qiu, H.J., Tong, G.Z., 2007. Genetic diversity and phylogenetic analysis of glycoprotein 5 of PRRSV isolates in mainland China from 1996 to 2006: coexistence of two NA-subgenotypes with great diversity.Vet. Microbiol. 123, 43–52.
    74. Bavia ME, Hale LF, Malone JB, et al. Geographic information systems and the environment risk of schistosomiasis in Bahia. Brazial Am J Med Hgy, 1999, 60 (4): 566 -572
    75. Berinstein A H,S Sellers,D J King,and B S Seal. Use of a heteroduplex mobility assay to detect differences in the fusion protein cleavage site coding sequence among Newcastle disease virus isolates. J. Clin.Microbiol. 2001),39:3171–3178.
    76. Bruce S. Seal, Daniel J. King, Holly S. Sellers. The avian response to Newcastle disease virus. Developmental and Comparative Immunology, 2000,24:257-268.
    77. Burnett G A, et aL Performance of a perehery building with ACNV for laying hens. Farm Building Progress, 1989, (98): 19-23
    78. C. Hall, Economic analysis of the impact of adopting herd health control programs on smallholder dairy farms in Central Thailand. Agricultural Economics, 31 (2004): 335 -342
    79. Collins J E, Benfield D A, Christianson W T, Harris L, Hennings J C, Shaw D P, Goyal S M, McCullough S, Morrison R B, Joo H S, Isolateion of swine infertility and respiratory syndrome virus(isolate ATCC VR-2332) in North America and experimental reproduction of disease in gnotobiotic pigs. Journal of Veterinary Diagnostic Investigation, 1992, 4: 117-126.
    80. Collins M S, Strong 1, Alexander D J. Evaluation of the molecular basis of pathogenicity of the variant Newcastle disease viruses termed "pigeon PMV-1 viruses". Arch. Virol. 1994, 134(3-4):403-411.
    81. D. Klinkenberg. et al. The effectiveness of classical swine fever surveillance programmes in The Netherlands, Preventive Veterinary Medicine. 67(2005)19-37
    82. Dee SA, Molitor TW. Elimination of PRRS virus using test and removal process. Vet Rec 1998;143:474–6.
    83. Ellis J, Krakowka S, Allan G M, Clark E, Kennedy. The clinal Scope of procine reproductive and respiratory syndrome cirus infection has expanded since 1987; an alternative perspective. Veterinary Pathology, 1999, 36:262-265.
    84. ESRI. MapObjects Refrences: GIS and Mapping Component. GIS by ESRITM. 1996
    85. F. H. M. Tomassen, A decision-tree to optimise control measures during the early stage of a foot-and-mouth disease epidemic, Preventive Veterinary Medicine, 54 (2002): 301-324
    86. Fang, Y., Kimb, D., Ropp, S., Steen, P., Christopher-Hennings, J., Nelson E., Rowland, R.2004.Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States. Virus Research 100: 229–235
    87. FAO,“FAO Recommendations on the Prevention, Control and Eradication of Highly Pathogenic Avian Influenza in Asia”, FAO Position Paper Sep-04. Rome, Italy: FAO: Food and Agriculture Organization of the United Nations. AG Dept. - Animal Production and Health Division,2004.
    88. FAO, Otte, M. J. et al, Transboundary Animal Diseases: Assessment of Socio-Economic Impacts and Institutional Responses. Livestock Policy Discussion Paper No. 9. 2004
    89. FAO, Recommendations on the Prevention, Conlrol and Eradication of Highly PathogenicAvian Influenza (HPAI) in Asia, 2004
    90. Filmer D, et al. Comupter assisted control of growth in intensive poultry houses. Recent advances in animal nutritional in Australia. 1991, 298 -311
    91. Fouchier R. A, Munster V, Wallensten A, et al. Characterization of a novel influenza A virus hemagglutinin subtype(H16)obtained from black-headed gulls. J Virol,(2005,79(5): 2814-2822.
    92. Glass GE, Schwarts BS, Morgan JM, et al. Environmental risk factors for Lyme disease identified with geographic information systems. Am J Public Health, 1995, 85:944 -948
    93. Gorbalenya, A. E., L. Enjuanes, J. Ziebuhr , E. J. Snijder. 2006. Nidovirales: Evolving the largest RNA virus genome. Virus Research 117 17–37
    94. Grebennikova, T.V. D.F. Clouser,b A.C. Vorwald,b M.I .Genomic characterization of virulent, attenuated, and revertant passages of a North American porcine reproductive and respiratory syndrome virus strain Virology. 2004, 321;383– 390.
    95. Holland JH.Complex adaptive system[M].Boston:W inter,1992
    96. J.A. A. M. Buijtel, R.R M. Hnirne, A. A. Dijkhuizen, J. A. Renkema and J. P. T. M. Noordhuizen, Basic framework for the economic evaluation of animal health eonlrol programmes, Review of Science and Technology, 1996, 15 (3)
    97. J.P. Mchiemcy, A framework for the economic analysis of disease in farm livestock Preventive veterinary medicine, 13 (1992): 137 - 154
    98. James, The state of veterinary epidemiology and economics, Preventive veterinary Medicine. 67 (2005): 91 -99
    99. Jenny G. Cho, Scott A. Dee,Porcine reproductive and respiratory syndrome virus. Theriogenology 66 (2006) 655–662
    100. Keffaber K K. Reproductive failure of unknown etiology[J]. American Association of Swine Practitioners.News,1989. 1:1-9.
    101. Kennedy F. S, Zhou N. N, Cuan Y. I, et al. Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. virology, 1998,252:331-342.
    102. Key, K.F., et al., Development of a heteroduplex mobility assay to identify field isolates of porcine reproductive and respiratory syndrome virus with nucleotide sequences closely related to those of modified live-attenuated vaccines. J Clin Microbiol, 2003. 41(6): p. 2433-9
    103. Kiss, I., et al., Genetic variation of the prevailing porcine respiratory and reproductive syndrome viruses occurring on a pig farm upon vaccination. Arch Virol, 2006. 151(11): p. 2269-76.
    104. Kitron U, Blnseman JK, Jones CJ, Use of the Arc/Infor GIS to study the distribution of Lymc disease tick in an Hlinios country. Prey Vet Med. 1991.11:243 -248
    105. L.D' Haese, Economics of theileriosis control in Zambia, Tropical Medicine and International Health, 1999, 4 (9):49-57
    106. M. A. Stevenson, Area-level risks for BSE in British cattle before and after the July 1988meat and bone meal feed ban, Preventive veterinary medicine, in Press (2005)
    107. M.J. Otte, P. Chilonda. Animal Health Economics: an Introduction , 2000, FAO
    108. M.J. Otte, P. Chilonds. Animal Health Economics: an Introduction
    109. Mahul, B. Durand.Simulated economic consequences of foot-and-mouth disease epidemics and their public control in France. Preventive Veterinary Medicine 47 (2000): 23-38
    110. Martelli, P., et al., Protection and immune response in pigs intradermally vaccinated against porcine reproductive and respiratory syndrome (PRRS) and subsequently exposed to a heterologous European (Italian cluster) field strain. Vaccine, 2007. 25(17): p. 3400-8.
    111. Mebatsion T, koolen M J, de Vaan LT et al. Newcastle disease virus (NDV) Mmaker Vaccine: an immunodominant epitope on the nucleoprotein gene of NDV can be deleted or replaced by a foreign epitope. J Virol, 2002,76(20):10138-10146.
    112. Meng XJ. Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development. Vet Microbiol. 2000. 74(4):309-29.
    113. Meng XJ. Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development. Vet Microbiol. 2000. 74(4):309-29.
    114. Mengeling, W.L., et al., Identification and clinical assessment of suspected vaccine-related field strains of porcine reproductive and respiratory syndrome virus. Am J Vet Res, 1999. 60(3): p. 334-40.
    115. Mengeling,W.L., Lager,K.M., Vorwald,A.C. Clinical consequences of exposing pregnant N gilts to strains of porcine reproductive and respiratory syndrome(PRRS) virus isolated from field cases of“atypical”PRRS[J].American journal of veterinary reasearch. 59:1540-1544.
    116. Micbel-P, Wilson-JB Martin-SW, etc. Temporal And Geographical Distributions of Reported Cases of Escberichia Coli O157:H7 Infection In Ontaria Epidemiol-infect. 1999 Apr: 122 (2): 193-200
    117. Morrison T,et al. The activity to promote fusion of Newcastle disease virus RN glycoprotein. Joural of virology, 1991),65(2):813-822.
    118. Nagai Y H,Ogura, and H Klenk. Studies on the assembly of the envelope of Newcastle disease virus. Virology, 1976, 69:523-538.
    119. OIE. Terrestrial Health Code 2005.Article 1.3.5.5[S]
    120. P. B. M. Berentsen, A dynamic model for cost-benefit analyses of foot-and-mouth disease control strategies, Preventive veterinary medicine, 12 (1992): 229 -243
    121. R. M. Bennett and J. Ijpelaar. Economic Assessment of Livestock Diseases in Great Britain, Final Report to the Department for Environment, Food and Rural Affairs, 19 September 2003
    122. R.M. Bennett, Ralph J. P. Blaney, Estimating the benefits of farm animal welfare legislation using the contingent valuation method, Agricultural Economics, 29 (2003): 85 -98
    123. Rossow K D, Shivers J L, Yeske P E, Polson D D, Rowland R R, Lawson S R, Murtaugh MP, Nelson E A, Collins J E. Porcine reproductive and respiratory syndrome virus infection in neonatal pigs characerized bymarkec neurovirulence [J]. The veterinary record, 1999, 144(16) :444-8.
    124. Sagrera A, Cobaleda C, Gonzalez De Buitrago J M, et al. Membrane glycoproteins of Newcastle disease virus: Nucleotide sequence of the hemagglutinin-neuraminidase cloned gene and structure function relationship of predicted amino acid sequence.Glycoconj J, 2001,18(4):283-289.
    125. Saito T, Kawaoka Y, Webster R. G. Phylogenetic analysis of the N8 neuraminidase gene of influenza A viruses.Virology, 1993,193(2):868-76.
    126. Sergeant D, et al. Computer visual tracking of poultry. Computers and Electronics in Agriculture. 1998, 21 (1): 1-18
    127. Song K D, Lillehoj H S, Choi K D, et al. A DNA Vaccine encoding a conserved Einmeria Protein induces protective immunity against live Eimeria acerrulina challenge. Vaccine, 2000, 19(2):243-252.
    128. Spradbrow P B. Newcastle Disease. Kluwer Academic Publishers, Boston, MA, 1988,247-255.
    129. Stadejek, T., Oleksiewicz, M.B., Potapchuk, D., Podgorska, K., 2006. Porcine reproductive and respiratory syndrome virus strains of exceptional diversity in Eastern Europe support the definition of new genetic subtypes. J. Gen. Virol. 87, 1835–1841.
    130. Stadejek, T., Stankevicius, A., Storgaard, T., Oleksiewicz, M.B., Belak, S., Drew, T.W., Pejsak, Z., 2002. Identification of radically different variants of porcine reproductive and respiratory syndrome virus in Eastern Europe: towards a common ancestor for European and American viruses. J. Gen. Virol. 83, 1861–1873.
    131. Thorne D H, et al. Automated high moisture diet feeding system for laying hens. Poultry Science, 1989, 68 (8): 1114 -1117
    132. Tian, K., et al., Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark. PLoS ONE, 2007. 2: p. e526.
    133. Timmons M B, et al. Computer management models for poultry systems. Paper-American Society of Agricultural Engineers. 1989. NO. 89-4045, 40
    134. V. Noordegraaf et al Sensitivity analysis by experimental design and metamodelling: Case study on simulation in national animal disease control. European Journal of Operational Research, 146 (2003): 433-443
    135. Vogel G.. Sequence offers clues to deadly flu. Science, 1998,279 (5349): 324.
    136. W. Schlosser, E. Ebel, Use of a Markov-chain Monte Carlo model to evaluate the time value of historical testing information in animal populations , Preventive Veterinary Medicine , 48 (2001): 167 -175
    137. W. Stott Costs and Benefits of Preventing Animal Diseases; A review focusing on endemicdiseases. October 2003
    138. Walker J W, B R Heron, and M A Mixson. Exotic Newcastle eradication program in the United States of America. Avian Dis, 1973,17:486-503.
    139. Wensvoort G, Terpstra C, Pol JM, ter Laak EA, Bloemraad M, de Kluyver EP, Kragten C, van Buiten L, den esten A, Wagenaar F,Mystery swine disease in the Netherlands:the isolation of Lelystad virus. Veterinary Quarterly, 1991,13:121-130.
    140. Widrow B, Lehr M. 30 years of adaptive neuarl network: perccptron, Madaline and BP. Proc IEEE, 1990 (9): 1415-1442
    141. World Bank, Spread of Avian Flu Could Affect Next Year’s Economic Outlook. In World Bank. (eds.). East Asia Update– Countering Global Shocks. Washington D.C.: USA, World Bank Press,2005.
    142. Yan-Jun Zhou, Hai Yu,, Zhi-Jun Tian,Genetic diversity of the ORF5 gene of porcine reproductive and respiratory syndrome virus isolates in China from 2006 to 2008. Virus Research 144 (2009) 136–144
    143. Zimmerman, J.J., Yoon, K.J., Wills, R.W., Swenson, S.L. 1997. General overview of PRRSV: a perspective from the United States. Veterinary Microbiology. 55:187-96.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700