益气活血汤治疗多发性神经病的临床研究
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摘要
目的:提出气虚血瘀是多发性神经病的主要病机之一,益气活血汤是该病的有效治疗方剂,并通过临床观察提供有效的证据。方法:临床选择符合诊断标准的64 例患者,随机分为治疗组和对照组,观察了患者的感觉障碍、肌无力症状以及肌电图和神经传导速度的情况,结果:临床研究显示,治疗组临床总有效率83.33%,对照组临床总有效率70.00%,两组有显著性差异(P﹤0.05)。结论:益气活血汤是治疗多发性神经病的有效方剂,该研究成果为多发性神经病的治疗提供了有效的思路和方法。
Objective: To study deficiency of qi and blood stasis are one of the important pathological mechanism of Polygneuropathy which belong to Flaccidity syndrome of TCM. Yiqi Huoxue recipe is the effective way to treat Polygneuropathy, and offered effective evidence by clinical observations. Methods: 64 patients choosed according to the diagnose standards were randomly divided into treatment group and control group. The sensory disturbance of patients, the myasthenic symptom, electromyograph and nerve conduction velocity were inspected. Results: The clinical research showed that the total effective rate of treatment group were 83.33% and control group were 70.00%(P<0.05). Conclusion: These results suggested that the patients with Ploygneuropathy treated with Yiqi Huoxue Recipe could get better effects. The research offered effective way to treat patients with Polygneuropathy.
Objective: To study deficiency of qi and blood stasis are one of the important pathological mechanism of Polygneuropathy which belong to Flaccidity syndrome of TCM. Yiqi Huoxue recipe is the effective way to treat Polygneuropathy, and offered effective evidence by clinical observations. Methods: 64 patients choosed according to the diagnose standards were randomly divided into treatment group and control group. The sensory disturbance of patients, the myasthenic symptom, electromyograph and nerve conduction velocity were inspected. Results: The clinical research showed that the total effective rate of treatment group were 83.33% and control group were 70.00%(P<0.05). Conclusion: These results suggested that the patients with Ploygneuropathy treated with Yiqi Huoxue Recipe could get better effects. The research offered effective way to treat patients with Polygneuropathy.
引文
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[4] 程悦耕,吴珍和.程亦成逐湿通络法治疗痿证经验.吉林中医药,1994,20 (5):5~6.
[5] 万继尧.重症肌无力症辨治经验.眼科通讯,1987,(l):7~8.
[6] 周伟昌.“肺热叶焦”:痿证主要病机的地位不容动摇.上海中医药杂志,1999, 10 (8):35.
[7] 范华昌.《痿论》质疑.上海中医药杂志,1998,10 (l1):41.
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[10] 赵俐黎.治痿独取阳明机理浅释.河南中医药学刊,1999,14(5):44~45.
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[12] 杨美芝,李爱华,曾红文.治痿独取阳明新探.按摩与导引,2003,20(2):9~10.
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[15] 何贤德,崔雪蓉.多发性神经炎的辨证论治简说.中医药学刊,2001,18(1):73~74.
[16] 林宗成.慢性多发性神经炎.中华实用中西医杂志,2002,2 (15):73.
[17] 张孟列.四妙丸加味治疗多发性神经病32 例.江西中医药,2004,35(253):50.
[18] 刘祖发,欧阳忠兴,陈翠,等.天荔汤治疗糖尿病多发性神经病临床观察.湖北中医杂志,1999,21(1):18.
[19] 周长胜.黄芪桂枝五物汤合当归四逆汤加减治疗多发性神经病.中国乡村医生, 2001,(3):29.
[20] 芦少敏.补脑膏治疗多发性神经病疗效观察.中国中医药信息杂志,2003,10(6):56.
[21] 何赞庄.自拟通经搜络饮治疗多发性神经炎20 例报告.安徽中医临床杂志,1999,11(4):244～245.
[22] 周卓宁,刘鹏.加用中药泡足治疗糖尿病性多发性神经病的疗效观察.广西中医药,2005,28(2):10~12.
[23] 张利威,郭公社,尚彦城等.末梢神经炎的外洗疗法.实用中西医结合杂志,1997,10(12):1213.
[24] 王新陆.中医外治法在神经系统疾病中的应用.山东中医杂志,2000,10,19(10):601～602.
[25] 曹金梅.针刺治疗糖尿病周围神经病变临床观察.中国针灸,1997,(10):627.
[26] 黄子黎.针刺配合穴位注射治疗末梢神经炎.中国针灸,1995,(2):26.
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[29] 史玉泉.实用神经病学,上海:上海科技出版社,1994,第二版:221.
[30] 张占忠,倪秀花.体外反搏治疗末梢神经炎30 例疗效观察.宁夏医学杂志, 2001,(09):33~34.
[31] 侯新芳,赵堂忠.淤泥疗法治疗周围神经炎.中国民间疗法, 2003,(05):33.
[32] 王孟林,方新连.蜂疗治愈多发性末梢神经炎108 例临床报告.蜜蜂杂志, 1995,(08):20~21.
[33] 高建,徐先祥,徐先俊等.黄芪总皂苷抗血栓作用实验研究.中成药,2002,24(2):116~117.
[34] 许艳,高佩畸,梁庆成等.黄芪多糖对脑血栓的疗效试验研究.中国血液流变学杂志,1999,9(3):133~136.
[35] 田吉梅,曹洋,陈燕等.黄芪对蟾蛛中枢、神经(神经-肌接头)和肌兴奋性及疲劳性的影响.四川中医,2005,23(1):15~16.
[36] 章梅,李旭,邱根全等.丹参注射液对糖尿病患者内皮NO、tPA 储备和血管舒 张功能的作用.中药材,2005,28(6):529~533.
[37] 黄琼.复方丹参方对血管性痴呆大鼠脑神经细胞凋亡的作用.湖北民族学院学报·医学版,2002, 19(4):29.
[38] 张明发.附子温里药理的研究.陕西中医,1994,15(2):88~ 91.
[39] 乐兆升等.53 种中草药抗血小板聚集作用的初步观察.中药通报,1985,10(1):44.
[40] 刘超,王静,杨军.赤芍总苷活血化瘀作用的研究.中药材,2000,23(9):557~560.
[41] 吴俊芳,刘少林,潘鑫鑫,等. 小檗碱对培养大鼠神经细胞“缺血”性损伤的保护作用.中国药理学通报,1999,15(3):243~246.
[42] 张玲玲,魏伟,严尚学,等.木瓜苷昔对小鼠胶原性关节炎的预防作用及初步机制.中国药理学通报,2004,20(1):95~100.
[43] Jacob vaya, Paula A Belinky. Antioxidant Constituents from Licorice Roots: Isolation, Structure Elucidation and Antioxida-tive Capacityt Oward LDL Oxidation. Free Radical Biology&Medicine. 1997,23(2):302.
[2] 张惠,痿证论治重在脾肾:胡建华临床经验.上海中医药杂志,1998,07,10; (7):7~9.
[3] 邓中光.对重症肌无力的认识.新中医,1988,(4):1.
[4] 程悦耕,吴珍和.程亦成逐湿通络法治疗痿证经验.吉林中医药,1994,20 (5):5~6.
[5] 万继尧.重症肌无力症辨治经验.眼科通讯,1987,(l):7~8.
[6] 周伟昌.“肺热叶焦”:痿证主要病机的地位不容动摇.上海中医药杂志,1999, 10 (8):35.
[7] 范华昌.《痿论》质疑.上海中医药杂志,1998,10 (l1):41.
[8] 刘殿永,付宁娜.痿证非尽为热证探悉.北京中医,1996,25(2):10~12.
[9] 黄先善.治痿何须独取阳明.浙江中医学院学报,1993,(4):6~7.
[10] 赵俐黎.治痿独取阳明机理浅释.河南中医药学刊,1999,14(5):44~45.
[11] 欧阳晓勇.治痿非独取阳明.云南中医学院学报,1996,19(3):25~26.
[12] 杨美芝,李爱华,曾红文.治痿独取阳明新探.按摩与导引,2003,20(2):9~10.
[13] 赵世运,尚学瑞.“治痿独取阳明”阐义.河南中医药学刊,2002,17(6):3~4.
[14] 初燕生.重症肌无力证治举隅.中医药学报,1988,(2):32 .
[15] 何贤德,崔雪蓉.多发性神经炎的辨证论治简说.中医药学刊,2001,18(1):73~74.
[16] 林宗成.慢性多发性神经炎.中华实用中西医杂志,2002,2 (15):73.
[17] 张孟列.四妙丸加味治疗多发性神经病32 例.江西中医药,2004,35(253):50.
[18] 刘祖发,欧阳忠兴,陈翠,等.天荔汤治疗糖尿病多发性神经病临床观察.湖北中医杂志,1999,21(1):18.
[19] 周长胜.黄芪桂枝五物汤合当归四逆汤加减治疗多发性神经病.中国乡村医生, 2001,(3):29.
[20] 芦少敏.补脑膏治疗多发性神经病疗效观察.中国中医药信息杂志,2003,10(6):56.
[21] 何赞庄.自拟通经搜络饮治疗多发性神经炎20 例报告.安徽中医临床杂志,1999,11(4):244～245.
[22] 周卓宁,刘鹏.加用中药泡足治疗糖尿病性多发性神经病的疗效观察.广西中医药,2005,28(2):10~12.
[23] 张利威,郭公社,尚彦城等.末梢神经炎的外洗疗法.实用中西医结合杂志,1997,10(12):1213.
[24] 王新陆.中医外治法在神经系统疾病中的应用.山东中医杂志,2000,10,19(10):601～602.
[25] 曹金梅.针刺治疗糖尿病周围神经病变临床观察.中国针灸,1997,(10):627.
[26] 黄子黎.针刺配合穴位注射治疗末梢神经炎.中国针灸,1995,(2):26.
[27] 姜华琦.针灸治疗末梢神经炎72 例.国医论坛,1995,(2):32.
[28] 王希军,张兆全,丁莉.手三里穴位注射配合中药治疗上肢末梢神经炎28 例.福建中医药,2003,34(4):4.
[29] 史玉泉.实用神经病学,上海:上海科技出版社,1994,第二版:221.
[30] 张占忠,倪秀花.体外反搏治疗末梢神经炎30 例疗效观察.宁夏医学杂志, 2001,(09):33~34.
[31] 侯新芳,赵堂忠.淤泥疗法治疗周围神经炎.中国民间疗法, 2003,(05):33.
[32] 王孟林,方新连.蜂疗治愈多发性末梢神经炎108 例临床报告.蜜蜂杂志, 1995,(08):20~21.
[33] 高建,徐先祥,徐先俊等.黄芪总皂苷抗血栓作用实验研究.中成药,2002,24(2):116~117.
[34] 许艳,高佩畸,梁庆成等.黄芪多糖对脑血栓的疗效试验研究.中国血液流变学杂志,1999,9(3):133~136.
[35] 田吉梅,曹洋,陈燕等.黄芪对蟾蛛中枢、神经(神经-肌接头)和肌兴奋性及疲劳性的影响.四川中医,2005,23(1):15~16.
[36] 章梅,李旭,邱根全等.丹参注射液对糖尿病患者内皮NO、tPA 储备和血管舒 张功能的作用.中药材,2005,28(6):529~533.
[37] 黄琼.复方丹参方对血管性痴呆大鼠脑神经细胞凋亡的作用.湖北民族学院学报·医学版,2002, 19(4):29.
[38] 张明发.附子温里药理的研究.陕西中医,1994,15(2):88~ 91.
[39] 乐兆升等.53 种中草药抗血小板聚集作用的初步观察.中药通报,1985,10(1):44.
[40] 刘超,王静,杨军.赤芍总苷活血化瘀作用的研究.中药材,2000,23(9):557~560.
[41] 吴俊芳,刘少林,潘鑫鑫,等. 小檗碱对培养大鼠神经细胞“缺血”性损伤的保护作用.中国药理学通报,1999,15(3):243~246.
[42] 张玲玲,魏伟,严尚学,等.木瓜苷昔对小鼠胶原性关节炎的预防作用及初步机制.中国药理学通报,2004,20(1):95~100.
[43] Jacob vaya, Paula A Belinky. Antioxidant Constituents from Licorice Roots: Isolation, Structure Elucidation and Antioxida-tive Capacityt Oward LDL Oxidation. Free Radical Biology&Medicine. 1997,23(2):302.