保肾巴布剂穴位敷贴治疗慢性肾脏病肾阳虚证肾阴虚证的临床疗效
|
摘要
目的
观察保肾巴布剂穴位敷贴疗法对慢性肾脏病肾阳虚证肾阴虚证患者的临床疗效、不良反应,对其有效性和安全性作出评价,并与单纯西医治疗的对照组比较,探索一种治疗慢性肾脏病肾阳虚证肾阴虚证经济安全、疗效可靠、适宜推广的外治法。
方法
本研究患者8 0例,均来源于湖北省中医院肾内科门诊及住院病人,符合慢性肾脏病西医诊断标准及中医辨证分型标准。随机分为两组:保肾巴布剂穴位敷贴治疗组(简称为A组),西医治疗对照组(简称为B组),每组各40例。A组在西医常规治疗的基础上,予保肾巴布剂敷贴于双肾俞,命门,双复溜穴,隔天敷贴1次,每次6-8个小时,治疗时间定在三伏期间,中医辨证分型为肾阳虚证、肾阴虚证,分别用保肾1号巴布剂、保肾2号巴布剂敷贴。B组仅予西医常规治疗,不予敷贴治疗。两组疗程为1个月,治疗前后查尿常规、血生化、血糖、24小时尿蛋白定量等指标,并记录治疗前后患者临床症状及体征的变化,作出疗效评价。
结果
1 A组总有效率为82.5%,B组总有效率为65.0%,A组总体疗效与B组相比均有显著性差异(P＜0.05)。
2两组治疗前后的临床症状总积分相比均有显著性差异(P＜0.05),A组与B组相比有显著性差异(P＜0.05),表明两组均能有效改善患者临床症状,A组疗效优于B组。
3 A组对肾阳虚证有效率为87.0%,与B组(66.7%)相比有显著性差异(P＜0.05),表明A组对肾阳虚证的效果优于B组,A组对肾阴虚证有效率为76.50%,虽较B组(63.1%)相比明显,但在统计学上无显著性差异(P＞0.05),表明A组对肾阴虚证的效果与B组相近。
4两组中慢性肾小球肾炎患者治疗后24hupq、尿红细胞计数较治疗前均下降,具有显著性差异(P＜0.05),而A组与B组相比又有显著性差异(P＜0.05),表明A组在减少尿蛋白、尿血的作用上优于B组;两组中糖尿病肾病患者治疗后24hupq、空腹血糖及餐后两小时血糖较治疗前均有明显下降(P＜0.05),A组在降低24hupq、降低空腹血糖作用上优于B组(P＜0.05),在降低餐后两小时血糖作用上与B组相近(P＞0.05);两组病例中高血压肾病患者治疗后收缩压及24hupq较治疗前有明显降低(P＜0.05),舒张压治疗前后无变化(P＞0.05),在降低收缩压效果方面,A、B两组之间比较无显著性意义(P＞0.05),在减少24hupq上,A组优于B组(P＜0.05)。
5两组治疗后患者的BUN、Scr较治疗前均有不同程度的降低(P＜0.05),A组对于BUN的疗效优于B组(P＜0.05),对Scr的疗效与B组相比没有显著差异(P＞0.05)。
6安全性检测:治疗组与对照组治疗后肝功能、心电图、血常规、粪常规检测均无明显异常变化,治疗前虽有个别项目异常存在,但治疗后无加重;所有患者敷贴处皮肤无发红、水疱、疼痛、破溃等发生,表明保肾巴布剂安全有效,无毒副作用。
结论
临床观察表明:保肾巴布剂穴位敷贴治疗慢性肾脏病肾阳虚证肾阴虚证有较好的疗效。保肾巴布剂穴位敷贴疗法能明显改善慢性肾脏病患者临床症状,减少蛋白尿,控制血糖、血压,改善肾功能,提高患者生活质量,临床应用安全有效、无毒副作用,是治疗慢性肾脏病的一种简便有效方法,值得临床推广应用。
OBJECTIVE
To observe the curative effect and saftly of Baoshen Ba Bu plaster to treat chronic kidney diseases(CKD),(insufficiency type of kidney-Yang、insufficiency type of kidney-Yin)by point application in dog-days,,and search an easy economy safe effective method in treating CKD.
METHODS
All 80 patients were randomly divided into two groups:therapeutic group of Baoshen' Ba Bu plaster point application(GroupA,n=40),routine medicine control group(GroupB,n=40).According to requirement of disease two groups were treated with routine medicine.GroupA took Baoshen' Ba Bu plaster point appilication in dog-days,six to eight hours each time,every tow days.each.GroupB took routine medicine.The therapeutic period of two groups was one monthes.Then observing the difference of both curative and safe indexes between before and after treatments.
RESULTS
1.The total effective rate of groupA was 82.5%and that of groupB was 65.0%.There was significant difference between groupA and groupB(p＜0.05),which indicated that the total effect of groupA was better than that of groupB.
2.There was significant difference between before and after treatments in the total scores of two groups(p＜0.05),and there was significant score difference between groupA and groupB(p＜0.05),which indicated that two groups could improve the symptoms,and group A had better effect than groupB.
3.The total effective rate on insufficiency type of kidney-Yang of groupA was 87.0%,that of groupB was 66.7%.There was significant difference between groupA and groupB(p＜0.05),which indicated that the effect on insufficiency type of kidney-Yang of groupA was better than that of groupB.The total effective rate on insufficiency type of kidney-Yin of group A was 76.5%,that of group B was 63.1%.There was no significant difference between group A and group B(p＞0.05),which indicated that the effect on insufficiency type of kidney-Yin of group A was close to that of group B.
4.The two groups of CGN patients decrease 24hupq and RBC counting of urine,and the effect of groupA was better than that of groupB(p＜0.05);The two groups of DN could decrease the 24hupq and blood sugar(p＜0.05),The effect of groupA was better than that of groupB(p＜0.05).The two groups of HTN could decrease the 24hupq and blood pressure.But Statistical analysis showed that they didn't have obvious discrepancy on lowering blood pressure(p＞0.05),then the effect on decreasing 24hupq of group A was better than that of group B(p＜0.05).
5.Two groups could decrease BUN and Scr.The effect on decreasing BUN of groupA was better than that of groupB(p＜0.05).but the effect on decreasing Scr of group A was close to that of group B(p＞0.05).
6.There was no abnormality between before and after treatments among two groups which indicated that Baoshen' Ba Bu plaster point application was a safe、effect、no side effect and no toxicity treatment method for CKD.
CONCLUSION
The clinical observation showed that Baoshen' Ba Bu piaster point application had good effect on CKD(insufficiency type of kidney-Yang、insufficiency type of kidney-Yin).It could efficiently improve the symptoms,decrease 24hupq and blood sugar,improve renal function.And there was no any side effect of Baoshen' Ba Bu plaster.Baoshen' Ba Bu plaster point application was an effective convenient and safe treatment method for CKD.
观察保肾巴布剂穴位敷贴疗法对慢性肾脏病肾阳虚证肾阴虚证患者的临床疗效、不良反应,对其有效性和安全性作出评价,并与单纯西医治疗的对照组比较,探索一种治疗慢性肾脏病肾阳虚证肾阴虚证经济安全、疗效可靠、适宜推广的外治法。
方法
本研究患者8 0例,均来源于湖北省中医院肾内科门诊及住院病人,符合慢性肾脏病西医诊断标准及中医辨证分型标准。随机分为两组:保肾巴布剂穴位敷贴治疗组(简称为A组),西医治疗对照组(简称为B组),每组各40例。A组在西医常规治疗的基础上,予保肾巴布剂敷贴于双肾俞,命门,双复溜穴,隔天敷贴1次,每次6-8个小时,治疗时间定在三伏期间,中医辨证分型为肾阳虚证、肾阴虚证,分别用保肾1号巴布剂、保肾2号巴布剂敷贴。B组仅予西医常规治疗,不予敷贴治疗。两组疗程为1个月,治疗前后查尿常规、血生化、血糖、24小时尿蛋白定量等指标,并记录治疗前后患者临床症状及体征的变化,作出疗效评价。
结果
1 A组总有效率为82.5%,B组总有效率为65.0%,A组总体疗效与B组相比均有显著性差异(P＜0.05)。
2两组治疗前后的临床症状总积分相比均有显著性差异(P＜0.05),A组与B组相比有显著性差异(P＜0.05),表明两组均能有效改善患者临床症状,A组疗效优于B组。
3 A组对肾阳虚证有效率为87.0%,与B组(66.7%)相比有显著性差异(P＜0.05),表明A组对肾阳虚证的效果优于B组,A组对肾阴虚证有效率为76.50%,虽较B组(63.1%)相比明显,但在统计学上无显著性差异(P＞0.05),表明A组对肾阴虚证的效果与B组相近。
4两组中慢性肾小球肾炎患者治疗后24hupq、尿红细胞计数较治疗前均下降,具有显著性差异(P＜0.05),而A组与B组相比又有显著性差异(P＜0.05),表明A组在减少尿蛋白、尿血的作用上优于B组;两组中糖尿病肾病患者治疗后24hupq、空腹血糖及餐后两小时血糖较治疗前均有明显下降(P＜0.05),A组在降低24hupq、降低空腹血糖作用上优于B组(P＜0.05),在降低餐后两小时血糖作用上与B组相近(P＞0.05);两组病例中高血压肾病患者治疗后收缩压及24hupq较治疗前有明显降低(P＜0.05),舒张压治疗前后无变化(P＞0.05),在降低收缩压效果方面,A、B两组之间比较无显著性意义(P＞0.05),在减少24hupq上,A组优于B组(P＜0.05)。
5两组治疗后患者的BUN、Scr较治疗前均有不同程度的降低(P＜0.05),A组对于BUN的疗效优于B组(P＜0.05),对Scr的疗效与B组相比没有显著差异(P＞0.05)。
6安全性检测:治疗组与对照组治疗后肝功能、心电图、血常规、粪常规检测均无明显异常变化,治疗前虽有个别项目异常存在,但治疗后无加重;所有患者敷贴处皮肤无发红、水疱、疼痛、破溃等发生,表明保肾巴布剂安全有效,无毒副作用。
结论
临床观察表明:保肾巴布剂穴位敷贴治疗慢性肾脏病肾阳虚证肾阴虚证有较好的疗效。保肾巴布剂穴位敷贴疗法能明显改善慢性肾脏病患者临床症状,减少蛋白尿,控制血糖、血压,改善肾功能,提高患者生活质量,临床应用安全有效、无毒副作用,是治疗慢性肾脏病的一种简便有效方法,值得临床推广应用。
OBJECTIVE
To observe the curative effect and saftly of Baoshen Ba Bu plaster to treat chronic kidney diseases(CKD),(insufficiency type of kidney-Yang、insufficiency type of kidney-Yin)by point application in dog-days,,and search an easy economy safe effective method in treating CKD.
METHODS
All 80 patients were randomly divided into two groups:therapeutic group of Baoshen' Ba Bu plaster point application(GroupA,n=40),routine medicine control group(GroupB,n=40).According to requirement of disease two groups were treated with routine medicine.GroupA took Baoshen' Ba Bu plaster point appilication in dog-days,six to eight hours each time,every tow days.each.GroupB took routine medicine.The therapeutic period of two groups was one monthes.Then observing the difference of both curative and safe indexes between before and after treatments.
RESULTS
1.The total effective rate of groupA was 82.5%and that of groupB was 65.0%.There was significant difference between groupA and groupB(p＜0.05),which indicated that the total effect of groupA was better than that of groupB.
2.There was significant difference between before and after treatments in the total scores of two groups(p＜0.05),and there was significant score difference between groupA and groupB(p＜0.05),which indicated that two groups could improve the symptoms,and group A had better effect than groupB.
3.The total effective rate on insufficiency type of kidney-Yang of groupA was 87.0%,that of groupB was 66.7%.There was significant difference between groupA and groupB(p＜0.05),which indicated that the effect on insufficiency type of kidney-Yang of groupA was better than that of groupB.The total effective rate on insufficiency type of kidney-Yin of group A was 76.5%,that of group B was 63.1%.There was no significant difference between group A and group B(p＞0.05),which indicated that the effect on insufficiency type of kidney-Yin of group A was close to that of group B.
4.The two groups of CGN patients decrease 24hupq and RBC counting of urine,and the effect of groupA was better than that of groupB(p＜0.05);The two groups of DN could decrease the 24hupq and blood sugar(p＜0.05),The effect of groupA was better than that of groupB(p＜0.05).The two groups of HTN could decrease the 24hupq and blood pressure.But Statistical analysis showed that they didn't have obvious discrepancy on lowering blood pressure(p＞0.05),then the effect on decreasing 24hupq of group A was better than that of group B(p＜0.05).
5.Two groups could decrease BUN and Scr.The effect on decreasing BUN of groupA was better than that of groupB(p＜0.05).but the effect on decreasing Scr of group A was close to that of group B(p＞0.05).
6.There was no abnormality between before and after treatments among two groups which indicated that Baoshen' Ba Bu plaster point application was a safe、effect、no side effect and no toxicity treatment method for CKD.
CONCLUSION
The clinical observation showed that Baoshen' Ba Bu piaster point application had good effect on CKD(insufficiency type of kidney-Yang、insufficiency type of kidney-Yin).It could efficiently improve the symptoms,decrease 24hupq and blood sugar,improve renal function.And there was no any side effect of Baoshen' Ba Bu plaster.Baoshen' Ba Bu plaster point application was an effective convenient and safe treatment method for CKD.
引文
[1]府伟灵,黄君富.肾脏疾病标志物的研究概况[J].国外医学临床生物化学与检验学分册,2004,25(2):97-98
[2]郑法雷.慢性肾衰竭的营养治疗[J].中国中西医结合肾病杂志,2003,4(11):621-623
[3]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002年
[4]刘力生.中国高血压防治指南(2005年修订版)[M].北京:人民卫生出版社,2005年
[5]王海燕.慢性肾脏疾病防治的新概念[M].现代实用医学 2004,16(12):691-693
[6]Hebert,L.A.,Wilmer,W.A.,Falkenhain,M.E.,et al.Renoprotection:one or many therapies? Kidney Int,2001,59(4):1211
[7]沈自尹.肾阳虚证的定位研究[J].中国中西医结合杂志,1993,17(1):50-52
[8]钟厉勇,沈自尹,等.补肾健脾活血三类复方对下丘脑-垂体-肾上腺-胸腺轴及CRF基因表达的影响[J].中国中西医结合杂志,1997,17(1):39-41
[9]潘志恒.肾虚本质的现代研究进展[J].上海中医药杂志,1995,5:44-46
[10]吴水生,等.中老年性激素水平与不同肾虚证型关系研究[J].福建中医药,2000,2:4
[11]吴瑞荣.阴虚冠心病人尿17-羟基类固醇昼夜节律变化和脑的关系[J].中西医结合杂志,1982,2:100
[12]江部康二,等.肾阳虚和肾阴虚患者尿中17-羟基固醇和17-酮类固醇排泄值[J].国外医学,中医中药分册,1982(3):195
[13]方素钦,等.中老年人肾虚证和性激素及免疫功能的研究[J].福建中医药,2002(2):3
[14]徐斌.穴性论[J].中国针灸,1999(1):29-31
[15]叶建红.经络实质研究概况[J].云南中医学院学报,1999,22(4):38-41
[16]董洪涛,李静.经络穴位经皮给药系统的机理研究[J].甘肃中医,1999,12(5):58-59
[17]张笑平 主编.针灸作用机理研究[M].安徽.安徽科学技术出版,1983:5 7-60,186-192
[18]王本显编译.王雪苔审阅.国外对经络问题的研究.北京:人民卫生出版社,1984:246-248,311-313
[19]陈巩荪.耳针的临床运用.江苏:江苏科学技术出版社,1984:414-416
[20]徐瑾.巴布剂应用于中药领域的研究概况[J].湖南中医杂志,2006,22(1):81-82
[21]沈映君 主编.中药药理学[M].北京:人民卫生出版社,2000年
[22]朱玲平,徐宗佩.附子的药理作用研究进展[J].2004,17(4):2464-2466
[23]洗寒梅.肉桂用法改革初探[J].右江民族医学院学报,1996,18(2):512
[24]张明发.肉桂的药理作用及温里功效[J].陕西中医.1995,(16):39-42
[25]长谷川雅之.五味子、牛蒡子及细辛成分的抗肾病变作用[J].国外医学,中医中药分册,1990,12(6):47
[26]王冬梅,张存莉.黄精化学成分及其生物活性[J].西北林学院学报,2006,21(2):142-145
[27]柳全文,李民,等.穿山龙的成分、药理及临床应用研究概况[J].山东中医杂志1998,17(1):29-31
[28]张明发,范荣培,等.温里药镇痛作用研究[J].陕西中医,1989,10:231
[29]张明发,沈雅琴,等.花椒温中止痛药理研究[J].中国中药杂志,1991,16:494
[30]许青媛.花椒粗提取物对实验血栓形成及凝血系统的影响[J].中草药,1990.12:545
[31]陈星灿,刘定安,等.中药抗菌作用研究[J].中医药学报,1998,(1):36-37
[32]张明发,沈雅琴,等.丁香和肉桂对缺氧和受寒小鼠的影响[J].中药材,1990,13(8):34
[33]王璟.丁香药用价值介绍[J].基层中药杂志,2000,14(2):6
[34]傅文庆,张春爱,等.丁香对自由基清除作用和对麻蝇寿命影响的研究[J].实用老年医学,1994,8(4):166-168
[35]沈琦,蔡贞贞,等.中药丁香促进5-氟脲嘧啶透皮吸收的作用研究[J].中草药,1999,30(8):601-602
[36]雷载权 主编.中药学[M].上海:上海科学技术出版社,1995年
[37]刘洋.冰片的药理实验研究概况[J].天津中医药,2003,20(8):85-87
[38]Abbate,M.,Zoja,C.,Rottoli,D.,et al.AntiProteinuric therapy while preventing the abnormal protein traffic in proximal tubule abrogates protein and complement_dependent interstitial inflammation in experimental renal disease.J Am Soc Nephrol,1999,10(4):804-13
[39]Nomura,A.,Morita,Y.,Maruyama,S.,et al.Role of Complement in acute tubulointerstitial injury of rats with aminonucleosid enephrosis.Am J Pathol,1997,151(2):539-47
[40]Mezzano,S.A.,Droguett,M.A.,Burgos,M.E.,et al.Overexpression of chemokines,fibrogenic,cytokines,and myotibroblasts in human membranous nephropathy.Kidney Int,2000,57(1):147-58
[41]Terzi,F.,Burtin,M.,and Friedlander,G.Early molecular mechanisms in the progression of renal failure:role of growth faetors and protooncogenes.Kidney Int Suppl,1998,65:568-73
[42]Vivian,E.M.,and Goebig,M.L.Slowing the progression of renal disease in diabetic patients.Ann Pharmacother,2001,35(4):452-63
[43]Remuzzi,G,Ruggenenti,P.,and Benigini,h.Understanding the nature of renal disease progression.Kidney Int,1997,15(1):2-15
[1]刘成,胡晋红,朱全刚.透皮吸收制剂基质的研究进展[J].中国新药杂志,2002,11(8):603-604.
[2]Cheng Y,Gao Y H,Wang L S.Kinetic characteristics of bomeol on transdermal velocity in differentmenstruums[J].Chin Tradit Herb D rugs,2000,31(8):607-609.
[3]刘淑芝.均匀设计法筛选中药巴布剂基质的研究[J].中国实验方剂学杂志,2001,7(1):17-18.
[4]马蓉.用正交试验法对巴布荆基质配比的研究[J].兰州医学院学报,2002,28(9):43.
[5]颜峰.中药巴布剂的研究-用正交试验法对巴布剂基质配比的研究[J].中成药,1992,14(9):2.
[6]刘淑芝.中药巴布剂制备工艺的实验研究[J].中国实验方剂学杂志,2001,7(3):9-11.
[7]徐瑾.巴布剂应用于中药领域的研究概况[J].湖南中医杂志,2006,22(1):81-82
[8]李奋儒,吴雪茹.“通泰”巴布剂的制备及临床观察[J].中药材,1998,21(7):376-377
[9]戴鸾春,欧阳强.癌痛宁巴布剂皮肤刺激性和致敏实验[J].时珍国医国药,2000,11(12):1063.
[10]陶寰,刘永年.癌痛宁巴布剂治疗癌性疼痛的临床与实验研究[J].中医杂志,2002,7(7):507-509
[11]万冬桂,吴玉华.癌痛患者伴发抑郁的相关因素及中医治疗[J].中国中医药信息杂志 2004,11(5):386-387
[12]毛林燕,杜勒,等.咳喘巴布膏治疗支气管哮喘缓解期32例临床观察[J],中医杂志,2004,5(5):354-356
[13]叶天申,谢文霞,等.巴布剂穴位贴敷治疗活动期类风湿性关节炎33例临床研究[J].江西中医学院学报,2005,17(6):23-24
[14]刘昌玉,张晶樱.喘敷灵巴布剂穴位敷贴防治小儿哮喘的实验研究[J],湖北中医学院硕士学位论文,2005.
[15]张琼,肖京,等.麝香通痹巴布膏治疗骨性关节炎(肝肾不足,筋脉瘀滞证)的临床研究[J],中国临床药理学与治疗学,2005,10(8):953-955
[16]肖雯晖,王香桂.中药巴布剂治疗痛经的主要药效学实验研究[J],中国实验方剂学杂志,2005,11(5):52-53
[17]孟舒,杨丹,等.玄丹巴布剂的制备及临床应用[J],中国医院药学杂,2006,26(12):1561-1562
[18]张萍,任永申,等.软肝消水巴布剂对S_(180)腹水模型小鼠的治疗作用[J],解放军药学学报,2007,23(4):259-262
[2]郑法雷.慢性肾衰竭的营养治疗[J].中国中西医结合肾病杂志,2003,4(11):621-623
[3]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002年
[4]刘力生.中国高血压防治指南(2005年修订版)[M].北京:人民卫生出版社,2005年
[5]王海燕.慢性肾脏疾病防治的新概念[M].现代实用医学 2004,16(12):691-693
[6]Hebert,L.A.,Wilmer,W.A.,Falkenhain,M.E.,et al.Renoprotection:one or many therapies? Kidney Int,2001,59(4):1211
[7]沈自尹.肾阳虚证的定位研究[J].中国中西医结合杂志,1993,17(1):50-52
[8]钟厉勇,沈自尹,等.补肾健脾活血三类复方对下丘脑-垂体-肾上腺-胸腺轴及CRF基因表达的影响[J].中国中西医结合杂志,1997,17(1):39-41
[9]潘志恒.肾虚本质的现代研究进展[J].上海中医药杂志,1995,5:44-46
[10]吴水生,等.中老年性激素水平与不同肾虚证型关系研究[J].福建中医药,2000,2:4
[11]吴瑞荣.阴虚冠心病人尿17-羟基类固醇昼夜节律变化和脑的关系[J].中西医结合杂志,1982,2:100
[12]江部康二,等.肾阳虚和肾阴虚患者尿中17-羟基固醇和17-酮类固醇排泄值[J].国外医学,中医中药分册,1982(3):195
[13]方素钦,等.中老年人肾虚证和性激素及免疫功能的研究[J].福建中医药,2002(2):3
[14]徐斌.穴性论[J].中国针灸,1999(1):29-31
[15]叶建红.经络实质研究概况[J].云南中医学院学报,1999,22(4):38-41
[16]董洪涛,李静.经络穴位经皮给药系统的机理研究[J].甘肃中医,1999,12(5):58-59
[17]张笑平 主编.针灸作用机理研究[M].安徽.安徽科学技术出版,1983:5 7-60,186-192
[18]王本显编译.王雪苔审阅.国外对经络问题的研究.北京:人民卫生出版社,1984:246-248,311-313
[19]陈巩荪.耳针的临床运用.江苏:江苏科学技术出版社,1984:414-416
[20]徐瑾.巴布剂应用于中药领域的研究概况[J].湖南中医杂志,2006,22(1):81-82
[21]沈映君 主编.中药药理学[M].北京:人民卫生出版社,2000年
[22]朱玲平,徐宗佩.附子的药理作用研究进展[J].2004,17(4):2464-2466
[23]洗寒梅.肉桂用法改革初探[J].右江民族医学院学报,1996,18(2):512
[24]张明发.肉桂的药理作用及温里功效[J].陕西中医.1995,(16):39-42
[25]长谷川雅之.五味子、牛蒡子及细辛成分的抗肾病变作用[J].国外医学,中医中药分册,1990,12(6):47
[26]王冬梅,张存莉.黄精化学成分及其生物活性[J].西北林学院学报,2006,21(2):142-145
[27]柳全文,李民,等.穿山龙的成分、药理及临床应用研究概况[J].山东中医杂志1998,17(1):29-31
[28]张明发,范荣培,等.温里药镇痛作用研究[J].陕西中医,1989,10:231
[29]张明发,沈雅琴,等.花椒温中止痛药理研究[J].中国中药杂志,1991,16:494
[30]许青媛.花椒粗提取物对实验血栓形成及凝血系统的影响[J].中草药,1990.12:545
[31]陈星灿,刘定安,等.中药抗菌作用研究[J].中医药学报,1998,(1):36-37
[32]张明发,沈雅琴,等.丁香和肉桂对缺氧和受寒小鼠的影响[J].中药材,1990,13(8):34
[33]王璟.丁香药用价值介绍[J].基层中药杂志,2000,14(2):6
[34]傅文庆,张春爱,等.丁香对自由基清除作用和对麻蝇寿命影响的研究[J].实用老年医学,1994,8(4):166-168
[35]沈琦,蔡贞贞,等.中药丁香促进5-氟脲嘧啶透皮吸收的作用研究[J].中草药,1999,30(8):601-602
[36]雷载权 主编.中药学[M].上海:上海科学技术出版社,1995年
[37]刘洋.冰片的药理实验研究概况[J].天津中医药,2003,20(8):85-87
[38]Abbate,M.,Zoja,C.,Rottoli,D.,et al.AntiProteinuric therapy while preventing the abnormal protein traffic in proximal tubule abrogates protein and complement_dependent interstitial inflammation in experimental renal disease.J Am Soc Nephrol,1999,10(4):804-13
[39]Nomura,A.,Morita,Y.,Maruyama,S.,et al.Role of Complement in acute tubulointerstitial injury of rats with aminonucleosid enephrosis.Am J Pathol,1997,151(2):539-47
[40]Mezzano,S.A.,Droguett,M.A.,Burgos,M.E.,et al.Overexpression of chemokines,fibrogenic,cytokines,and myotibroblasts in human membranous nephropathy.Kidney Int,2000,57(1):147-58
[41]Terzi,F.,Burtin,M.,and Friedlander,G.Early molecular mechanisms in the progression of renal failure:role of growth faetors and protooncogenes.Kidney Int Suppl,1998,65:568-73
[42]Vivian,E.M.,and Goebig,M.L.Slowing the progression of renal disease in diabetic patients.Ann Pharmacother,2001,35(4):452-63
[43]Remuzzi,G,Ruggenenti,P.,and Benigini,h.Understanding the nature of renal disease progression.Kidney Int,1997,15(1):2-15
[1]刘成,胡晋红,朱全刚.透皮吸收制剂基质的研究进展[J].中国新药杂志,2002,11(8):603-604.
[2]Cheng Y,Gao Y H,Wang L S.Kinetic characteristics of bomeol on transdermal velocity in differentmenstruums[J].Chin Tradit Herb D rugs,2000,31(8):607-609.
[3]刘淑芝.均匀设计法筛选中药巴布剂基质的研究[J].中国实验方剂学杂志,2001,7(1):17-18.
[4]马蓉.用正交试验法对巴布荆基质配比的研究[J].兰州医学院学报,2002,28(9):43.
[5]颜峰.中药巴布剂的研究-用正交试验法对巴布剂基质配比的研究[J].中成药,1992,14(9):2.
[6]刘淑芝.中药巴布剂制备工艺的实验研究[J].中国实验方剂学杂志,2001,7(3):9-11.
[7]徐瑾.巴布剂应用于中药领域的研究概况[J].湖南中医杂志,2006,22(1):81-82
[8]李奋儒,吴雪茹.“通泰”巴布剂的制备及临床观察[J].中药材,1998,21(7):376-377
[9]戴鸾春,欧阳强.癌痛宁巴布剂皮肤刺激性和致敏实验[J].时珍国医国药,2000,11(12):1063.
[10]陶寰,刘永年.癌痛宁巴布剂治疗癌性疼痛的临床与实验研究[J].中医杂志,2002,7(7):507-509
[11]万冬桂,吴玉华.癌痛患者伴发抑郁的相关因素及中医治疗[J].中国中医药信息杂志 2004,11(5):386-387
[12]毛林燕,杜勒,等.咳喘巴布膏治疗支气管哮喘缓解期32例临床观察[J],中医杂志,2004,5(5):354-356
[13]叶天申,谢文霞,等.巴布剂穴位贴敷治疗活动期类风湿性关节炎33例临床研究[J].江西中医学院学报,2005,17(6):23-24
[14]刘昌玉,张晶樱.喘敷灵巴布剂穴位敷贴防治小儿哮喘的实验研究[J],湖北中医学院硕士学位论文,2005.
[15]张琼,肖京,等.麝香通痹巴布膏治疗骨性关节炎(肝肾不足,筋脉瘀滞证)的临床研究[J],中国临床药理学与治疗学,2005,10(8):953-955
[16]肖雯晖,王香桂.中药巴布剂治疗痛经的主要药效学实验研究[J],中国实验方剂学杂志,2005,11(5):52-53
[17]孟舒,杨丹,等.玄丹巴布剂的制备及临床应用[J],中国医院药学杂,2006,26(12):1561-1562
[18]张萍,任永申,等.软肝消水巴布剂对S_(180)腹水模型小鼠的治疗作用[J],解放军药学学报,2007,23(4):259-262