摘要
本文通过临床研究,观察针刺治疗女性更年期抑郁症的临床疗效,并探讨其作用
机理。立足中医理论,结合现代医学研究成果,认为肾虚肝郁,阴阳失调,多脏腑功
能紊乱为本病的病因病机。治宜从整体出发,标本兼顾。故拟定了疏肝解郁、滋肾宁
心、协调阴阳、醒脑安神的治疗原则,并拟定肝俞、肾俞、心俞、足三里、三阴交、
神庭、本神、神聪为主的针灸处方,临床治疗女性更年期抑郁症患者30例,疗效显
著。
研究表明,女性进入更年期,因卵巢功能衰退、雌激素分泌减少而出现的神经内
分泌功能失调及单胺类神经递质含量降低是女性更年期抑郁症发生的重要因素。针刺
通过增强卵巢功能、延缓卵巢衰老来提高雌二醇(E2) 的含量,以增强激素内分泌环
境的稳定性,进而实现对神经内分泌系统整体的综合调节作用,使机体的内分泌系统、
神经系统处于相对稳定的状态。同时,通过针刺促进脑内5-羟色胺(5-HT)和去甲
肾上腺素(NE)、多巴胺(DA)等单胺类神经递质的大量释放,使其含量升高,从而
使临床症状得到改善。针刺治疗女性更年期抑郁症以其简单方便、疗效可靠、无副作
用的特点,为本病的临床治疗提供了一条新的思路。
Objective: To observe the therapeutic effect of acupuncture on femals'climacteric age depression,and to explore its operating mechanism.
Method: 60 patients were randomly dividied into a treatment group(30 cases treated by acupuncture)and a control group(30 cases treated by antidepression drugs).they were treated for 6 weeks,HAMD, HAMA Rating Scale and Kupperman index were used to assess therapeutic effects.The main symptoms, HAMD, HAMA and Kupperman index scores , blood follicle-stimulating hormone(FSH), estradiol(E2) ,5-hydroxy indoleacetic acid(5-HIAA) , noradrenaline(NE) , dopamine(DA) were observed before and after treatment. On the other hand, 15 volunteer healthy climacteric age women were selected as the normal control group in this study.
Result: There are 58 valid patients were statisticed in the end.In the treatment group,the highly effective rate and total effective rate were respectively 26.67%and 86.67%,depressant symptoms were obviously relieved.Result indicated that E2 and 5-HIAA,DA,NE were increased after acupuncture. FSH has no obvious change.There was no marked difference between the treatment of acupuncture and antidepression drugs(P>0.05),but compared with the control group,there was no side effect in the treatment group. So acupuncture has a obviously therapeutic effect in improving femals'climacteric age depression.
Conclusion: Acupuncture was a good method to treat femals' climacteric age depression, which realized its effect by adjusting whole body's function and increasing the function of ovary.
引文
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