摘要
物质成瘾主要特征为持续地、失去控制地对成瘾物质的渴求,以及持续的复吸倾向。由于这些特征,物质成瘾的临床治疗显得困难重重。尽管物质成瘾的主要理论各持所见,但均认可与成瘾物质使用相关的环境线索,在触发对成瘾物质的渴求和复吸行为中起了重要作用,类似于条件化环境线索对成瘾记忆的提取。
海马在环境线索相关的学习记忆中起着重要作用。海马突触可塑性,主要是指活动或经验依赖的长时程增强(Long-term potentiation,LTP)和长时程抑制(Long-term depression,LTD),被认为是海马依赖的学习与记忆的细胞分子基础。既往吗啡成瘾对海马突触可塑性影响的研究,常常是以记录单个通路的突触效能改变为基础(例如低频刺激诱导LTD、高频刺激诱导LTP),进而阐明突触可塑性在成瘾行为中的作用及其可能的机制。然而,学习记忆的行为学研究往往采用两种事件的条件化训练来进行,如经典的条件反射是通过条件刺激和非条件刺激来建立联合型学习。在动物实验中运动敏感化是常见的成瘾模型,由于环境线索和成瘾物质使用建立的联合型学习,运动敏感化往往只有在条件化环境中才能有效表达。最近研究进展表明,大鼠海马Schaffer-CA1双通路也存在类似于经典条件反射的联合型学习记忆规律,两个通路之间在一定时间内的协同作用,可在两个通路同时诱导出LTP和LTD,呈现为海马组合突触可塑性,体现了海马突触可塑性可能在学习记忆的编码过程中具有灵活性与稳定性的特点。鉴于条件化环境线索在成瘾记忆提取中的重要作用,我们认为基于双通路条件化作用的海马组合突触可塑性可能在成瘾过程中发挥着重要作用。
本研究采用了活体电生理、行为学、生化等方法,进行了了三方面研究:(1)以海马Schaffer-CA1双通路技术为基础,研究了大鼠Schaffer-CA1组合突触可塑性的分布特点;(2)在此基础上,研究了吗啡成瘾对大鼠Schaffer-CA1双通路组合突触可塑性的影响;(3)研究了吗啡反复戒断对大鼠Schaffer-CA1双通路组合突触可塑性以及大鼠行为敏感化的影响,并采用了免疫印迹法(Western Blotting)测定AMPAR(α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor)的GluR1(Glutamate receptor1)及GluR2/3(Glutamate receptor2/3)亚单位,在一次戒断、三次戒断后在大鼠海马膜蛋白及突触小体的表达。
在第一部分海马组合突触可塑性实验中,我们首次证实了海马突触可塑性在Schaffer-CA1双通路上呈现出四种组合:LTD/LTD,LTP/LTP,LTP/LTD,LTD/LTP。这表明了在信息编码过程中,LTP及LTD可能同时存在,呈现组合可塑性的特点,提供了信息处理过程中的稳定性,避免单一LTP或LTD产生时导致过度兴奋或抑制,同时由于不同突触的不同组合也提供了信息处理的灵活性。因此,推测信息加工可能是各种形式LTD与LTP的组合过程,类似于数字0,1进行组合编码。这种组合编码似乎更加合理,因为它有助于提高记忆编码效率及记忆容量,并有利于突触权重(Synaptic weight)的精确调节。
在第二部分实验中,我们首次将海马Schaffer-CA1双通路技术应用于吗啡成瘾的研究,我们发现慢性吗啡处理易化了LTD(LTD/LTD),伴随着吗啡戒断易化的LTD出现恢复的趋势,在戒断第四天逆转为LTP/LTD。我们认为这反映了突触效能的内稳态性适应(Homeostatic adaptations)过程,有利于吸毒和戒断相关线索建立条件化(Contextual conditioning),形成牢固的物质成瘾记忆。由于LTP/LTD组合可塑性能被NMDAR(N-methyl-D-aspartatereceptor)及D1/D5多巴胺受体阻断剂完全阻断,提示了通过激活多巴胺系统D1/D5受体,调控了谷氨酸系统的突触可塑性,可能是环境线索相关成瘾记忆的分子机制。
第三部分海马组合可塑性实验中,我们首次证实了三次戒断后LTP比一次戒断后的LTP幅值更大,持续更久,并表现为LTP/LTP组合;在行为敏感化实验中发现,三次戒断大鼠的自发活动均多于一次戒断(GluR1及GluR2/3在海马膜蛋白及突触小体表达的数据正在整理中)。结果提示多次戒断可进一步加强条件化环境线索相关的成瘾记忆,增强大鼠的觅药动机。进一步说明了戒断后的存在关键时间窗,促进了条件化环境线索相关成瘾记忆的形成,如能阻断LTP的形成,可能会熄灭环境线索相关联的成瘾记忆,从而减少条件化环境线索诱发的复吸行为。
Drug addiction is characterized by persistent and compulsive drug craving, drug seeking and persistence tendency to relapse, which is the major problem hampering clinical treatment of drug addiction. Ample evidence adds to a growing consensus that drug-associated contextual cues play an important role in triggering drug craving and relapse and the retrieval of addiction memory by conditioned contextual cues may be the underlying mechanism.
Hippocampus is known to be critical for the formation of certain type of memory including contextual cues-associated addiction memory. Hippocampal activity-dependent or experience-dependent synaptic plasticity, including Long-term potentiation (LTP) and Long-term depression (LTD), is believed to be the cellular and molecular mechanism which underlies hippocampus-dependent learning and memory. Hippocampal synaptic plasticity in the studies of morphine addiction is often examined by using one pathway recording technique, in which LTD is induced by low frequency stimulation (LFS) and LTP is induced by high frequency simulation (HFS). The results of those studies suggest that there should be a crosstalk between the potentiation or depression of hippocampal synaptic plasticity and the mechanism of addictive behavior. However behavioral learning, e.g. the classic conditioning, is based on the association between conditioned and unconditioned stimuli and in the experiment of locomotor sensitization to morphine, locomotor sensitization may be expressed sucessfully only in the conditioned context, which is based on unconditioned stimulus (morphine injection) in the conditioned environment (open field). Recent study indicates that hippocampal combinatorial synaptic plasticity can be induced by a similar conditioning procedure that conditioned stimuli between two Schaffer-CA1 pathways within a certain timing window induces LTP and LTD simultaneously, which illustrates the flexibility and stability of hippocampal synaptic plasticity. Since conditioned contextual cues may make critical contribution to relapse, hippocampal combinatorial synaptic plasticity based on conditioning of two pathways should be a candidate mechanism for long-lasting and unforgettable addiction memory.
In the present study, using in vivo electrophysiological, behavioral and biochemical methods, we carried out three sets of experiments. In the first set of experiments, we examined the distribution of hippocampal combinatorial synaptic plasticity in two converging Schaffer-CA1 pathways in rat; in the second set of experiments, we examined the effects of morphine addiction on hippocampal combinatorial synaptic plasticity; in the third set of experiments, we examined the effects of repetitive withdrawal on hippocampal combinatorial synaptic plasticity. We also used immunoblots (Western Blotting) to asses the expression of GluR1 (Glutamate receptor1) and GluR2/3 (Glutamate receptor2/3) subunits of the AMPAR, which is the major receptor responsible for the expression and maintenance of LTP and LTD, in the total membrane fraction and the synaptosome fractions of the hippocampus after one time and third times of morphine withdrawal.
In the first set of experiment, we demonstrated for first time that there are four types of combinatorial synaptic plasticity, i.e. LTD/LTD, LTP/LTD, LTD/LTP and LTP/LTP. The results implicate that LTD and LTP may coexist and concomitantly encode information, which provides the stability of the hippocampal synaptic plasticity and makes contribution to limit the tendency to drive synaptic strength towards potentially epileptogenic level of LTP or minimum value and shows the flexibility of encoding process which may be similar to encoding information by digital 0 and 1. Combinatorial plasticity may encode the information more efficiently and may enhance the capacity for the storage of memory traces compared with encoding process mediated by LTP or LTD independently, which provide the possibility to reset synaptic weight and update synaptic configuration delicately.
In the second set of experiment, we first introduced the dual Schaffer-CA1 pathways experiments to examine hippocampal combinatorial synaptic plasticity after repeated morphine exposure. We observed that repeated morphine exposure facilitated LTD (LTD/LTD), which was gradually restored following morphine withdrawal. However on withdrawal day 4, LTP/LTD was induced. Thus, from drug taking to withdrawal, homeostatic adaptations and contextual conditioning may be the mechanism underlying contextual cues-associated addiction memory. Since LTD or LTP was fully blocked by antagonists to NMDAR and D1/D5 receptors, it seems that morphine may employ dopamine system to modulate glutamatergic LTP and LTD which may be the molecular mechanism of the conditioned contextual cues which can retrieve addiction memory.
In the third set of experiments, we demonstrated for first time that LTP after three times of withdrawal was enhanced as compared with that after one time of withdrawal and combinatorial plasticity was remarkable LTP/LTP as compared with LTP/LTD after one time of withdrawal. Consistent with this result, locomotor activity after three times of withdrawal was largely increased as compared with that after one time of withdrawal. The data of the expression of GluR1 and GluR2/3 are in preparation. Our findings suggest that the more times of withdrawal, the more possibilities of combinatorial plasticity would be LTP/LTP that may be responsible for stronger contextual cues-associated addiction memory and drug-seeking behavior. These results reveal that acute withdrawal may be critical in the formation of contextual cues-associated addiction memory and effective block of hippocampal LTP induction may contribute to the extinction of contextual cues-associated addiction memory and thereby decrease the tendency to relapse evoked by conditioned contextual cues.
引文
Abbott LF,Nelson SB(2000) Synaptic plasticity:taming the beast.Nat Neurosci 3Suppl:1178-1183.
Abbott LF,Regehr WG(2004) Synaptic computation.Nature 431:796-803.
Abraham WC(2003) How long will long-term potentiation last? Philos Trans R Soc Lond B Biol Sci 358:735-744.
Abraham WC,Bear MF(1996) Metaplasticity:the plasticity of synaptic plasticity.Trends Neurosci 19:126-130.
Abraham WC,Williams JM(2003) Properties and mechanisms of LTP maintenance.Neuroscientist 9:463-474.
Abraham WC,Robins A(2005) Memory retention--the synaptic stability versus plasticity dilemma.Trends Neurosci 28:73-78.
Abraham WC,Bliss TV,Goddard GV(1985) Heterosynaptic changes accompany long-term but not short-term potentiation of the perforant path in the anaesthetized rat.J Physiol 363:335-349.
Abraham WC,Logan B,Greenwood JM,Dragunow M(2002) Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the hippocampus.J Neurosci 22:9626-9634.
Adler J(1966) Chemotaxis in bacteria.Science 153:708-716.
Ahmed SH,Walker JR,Koob GF(2000) Persistent increase in the motivation to take heroin in rats with a history of drug escalation.Neuropsychopharmacology 22:413-421.
Alvarado MC,Bachevalier J(2005) Comparison of the effects of damage to the perirhinal and parahippocampal cortex on transverse patterning and location memory in rhesus macaques.J Neurosci 25:1599-1609.
Andersen P,Sundberg SH,Sveen O,Swann JW,Wigstrom H(1980) Possible mechanisms for long-lasting potentiation of synaptic transmission in hippocampal slices from guinea-pigs.J Physiol 302:463-482.
Anderson SM,Bari AA,Pierce RC(2003) Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats.Psychopharmacology(Berl) 168:132-138.
Anderson SM,Famous KR,Sadri-Vakili G,Kumaresan V,Schmidt HD,Bass CE,Terwilliger EF,Cha JH,Pierce RC(2008) CaMKⅡ:a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.Nat Neurosci 11:344-353.
Attwell PJ,Cooke SF,Yeo CH(2002) Cerebellar function in consolidation of a motor memory.Neuron 34:1011-1020.
Bachtell RK,Whisler K,Karanian D,Self DW(2005) Effects of intra-nucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat.Psychopharmacology (Berl) 183:41-53.
Bailey CH, Giustetto M, Huang YY, Hawkins RD, Kandel ER (2000) Is heterosynaptic modulation essential for stabilizing Hebbian plasticity and memory? Nat Rev Neurosci 1:11 -20.
Baldwin AE, Sadeghian K, Kelley AE (2002) Appetitive instrumental learning requires coincident activation of NMDA and dopamine D1 receptors within the medial prefrontal cortex. J Neurosci 22:1063-1071.
Bardo MT, Bevins RA (2000) Conditioned place preference: what does it add to our preclinical understanding of drug reward? Psychopharmacology (Berl) 153:31-43.
Barria A, Muller D, Derkach V, Griffith LC, Soderling TR (1997) Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science 276:2042-2045.
Barrionuevo G, Schottler F, Lynch G (1980) The effects of repetitive low frequency stimulation on control and "potentiated" synaptic responses in the hippocampus. Life Sci 27:2385-2391.
Bear MF (2003) Bidirectional synaptic plasticity: from theory to reality. Philos Trans R Soc Lond B Biol Sci 358:649-655.
Bear MF, Abraham WC (1996) Long-term depression in hippocampus. Annu Rev Neurosci 19:437-462.
Beattie EC, Carroll RC, Yu X, Morishita W, Yasuda H, von Zastrow M, Malenka RC (2000) Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat Neurosci 3:1291-1300.
Bender VA, Bender KJ, Brasier DJ, Feldman DE (2006) Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. J Neurosci 26:4166-4177.
Beninger RJ, Miller R (1998) Dopamine D1-like receptors and reward-related incentive learning. Neurosci Biobehav Rev 22:335-345.
Berger TW, Rinaldi PC, Weisz DJ, Thompson RF (1983) Single-unit analysis of different hippocampal cell types during classical conditioning of rabbit nictitating membrane response. J Neurophysiol 50:1197-1219.
Berke JD, Hyman SE (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25:515-532.
Berridge KC, Robinson TE (2003) Parsing reward. Trends Neurosci 26:507-513.
Bi G, Poo M (2001) Synaptic modification by correlated activity: Hebb's postulate revisited. Annu Rev Neurosci 24:139-166.
Bi GQ, Poo MM (1998) Synaptic modifications in cultured hippocampal neurons:dependence on spike timing, synaptic strength, and postsynaptic cell type. J Neurosci 18:10464-10472.
Bienenstock EL, Cooper LN, Munro PW (1982) Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J Neurosci 2:32-48.
Bliss TV, Gardner-Medwin AR (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the unanaestetized rabbit following stimulation of the perforant path. J Physiol 232:357-374.
Bliss TV, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. JPhysiol 232:331-356.
Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R, Landau EM (1998) Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science 280:1940-1942.
Boehm J, Kang MG, Johnson RC, Esteban J, Huganir RL, Malinow R (2006) Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1. Neuron 51:213-225.
Bramham CR, Messaoudi E (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 76:99-125.
Brebner K, Wong TP, Liu L, Liu Y, Campsall P, Gray S, Phelps L, Phillips AG, Wang YT (2005) Nucleus accumbens long-term depression and the expression of behavioral sensitization. Science 310:1340-1343.
Bredt DS, Nicoll RA (2003) AMPA receptor trafficking at excitatory synapses.Neuron 40:361-379.
Burns LH, Robbins TW, Everitt BJ (1993) Differential effects of excitotoxic lesions of the basolateral amygdala, ventral subiculum and medial prefrontal cortex on responding with conditioned reinforcement and locomotor activity potentiated by intra-accumbens infusions of D-amphetamine. Behav Brain Res 55:167-183.
Burwell RD (2000) The parahippocampal region: corticocortical connectivity. Ann N Y Acad Sci 911:25-42.
Caine SB, Humby T, Robbins TW, Everitt BJ (2001) Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions:locomotion, cocaine self-administration, and prepulse inhibition of startle.Behav Neurosci 115:880-894.
Caporale N, Dan Y (2008) Spike timing-dependent plasticity: a Hebbian learning rule. Annu Rev Neurosci 31:25-46.
Cardinal RN, Parkinson JA, Hall J, Everitt BJ (2002) Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 26:321-352.
Carlezon WA, Jr., Nestler EJ (2002) Elevated levels of GluRl in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci 25:610-615.
Carlezon WA, Jr., Boundy VA, Haile CN, Lane SB, Kalb RG, Neve RL, Nestler EJ (1997) Sensitization to morphine induced by viral-mediated gene transfer.Science 277:812-814.
Carroll RC, Beattie EC, von Zastrow M, Malenka RC (2001) Role of AMPA receptor endocytosis in synaptic plasticity. Nat Rev Neurosci 2:315-324.
Cash S, Yuste R (1998) Input summation by cultured pyramidal neurons is linear and position-independent. J Neurosci 18:10-15.
Cepeda C, Buchwald NA, Levine MS (1993) Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated. Proc Natl Acad Sci U S A 90:9576-9580.
Cepeda C, Colwell CS, Itri JN, Gruen E, Levine MS (1998) Dopaminergic modulation of early signs of excitotoxicity in visualized rat neostriatal neurons. Eur J Neurosci 10:3491-3497.
Chao SZ, Ariano MA, Peterson DA, Wolf ME (2002) D1 dopamine receptor stimulation increases GluRl surface expression in nucleus accumbens neurons.J Neurochem 83:704-712.
Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA (2000) Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408:936-943.
Chevaleyre V, Takahashi KA, Castillo PE (2006) Endocannabinoid-mediated synaptic plasticity in the CNS. Annu Rev Neurosci 29:37-76.
Childress AR, Hole AV, Ehrman RN, Robbins SJ, McLellan AT, O'Brien CP (1993) Cue reactivity and cue reactivity interventions in drug dependence. NIDA Res Monogr 137:73-95.
Childress AR, Mozley PD, McElgin W, Fitzgerald J, Reivich M, O'Brien CP (1999) Limbic activation during cue-induced cocaine craving. Am J Psychiatry 156:11-18.
Citri A, Malenka RC (2008) Synaptic plasticity: multiple forms, functions, and mechanisms. Neuropsychopharmacology 33:18-41.
Collingridge GL, Isaac JT, Wang YT (2004) Receptor trafficking and synaptic plasticity. Nat Rev Neurosci 5:952-962.
Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng LJ, Shaham Y, Marinelli M,Wolf ME (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118-121.
Crombag HS, Shaham Y (2002) Renewal of drug seeking by contextual cues after prolonged extinction in rats. Behav Neurosci 116:169-173.
Crombag HS, Bossert JM, Koya E, Shaham Y (2008) Review. Context-induced relapse to drug seeking: a review. Philos Trans R Soc Lond B Biol Sci 363:3233-3243.
Cui Z, Wang H, Tan Y, Zaia KA, Zhang S, Tsien JZ (2004) Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron 41:781-793.
Dalley JW, Laane K, Theobald DE, Armstrong HC, Corlett PR, Chudasama Y,Robbins TW (2005) Time-limited modulation of appetitive Pavlovian memory by Dl and NMDA receptors in the nucleus accumbens. Proc Natl Acad Sci U S A 102:6189-6194.
Dan Y, Poo MM (2004) Spike timing-dependent plasticity of neural circuits. Neuron 44:23-30.
Das S, Grunert M, Williams L, Vincent SR (1997) NMDA and Dl receptors regulate the phosphorylation of CREB and the induction of c-fos in striatal neurons in primary culture. Synapse 25:227-233.
Davis GW (2006) Homeostatic control of neural activity: from phenomenology to molecular design. Annu Rev Neurosci 29:307-323.
Dayan P, Willshaw DJ (1991) Optimising synaptic learning rules in linear associative memories. Biol Cybern 65:253-265.
De Vries TJ, Schoffelmeer AN, Binnekade R, Mulder AH, Vanderschuren LJ (1998) Drug-induced reinstatement of heroin- and cocaine-seeking behaviour following long-term extinction is associated with expression of behavioural sensitization. Eur J Neurosci 10:3565-3571.
Debiec J, LeDoux JE, Nader K (2002) Cellular and systems reconsolidation in the hippocampus. Neuron 36:527-538.
Derkach V, Barria A, Soderling TR (1999) Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors. Proc Natl Acad Sci U S A 96:3269-3274.
Derkach VA, Oh MC, Guire ES, Soderling TR (2007) Regulatory mechanisms of AMPA receptors in synaptic plasticity. Nat Rev Neurosci 8:101-113.
Di Ciano P, Cardinal RN, Cowell RA, Little SJ, Everitt BJ (2001) Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior. J Neurosci 21:9471-9477.
Dong Y, Saal D, Thomas M, Faust R, Bonci A, Robinson T, Malenka RC (2004) Cocaine-induced potentiation of synaptic strength in dopamine neurons:behavioral correlates in GluRA(-/-) mice. Proc Natl Acad Sci U S A 101:14282-14287.
Dong Z, Han H, Cao J, Zhang X, Xu L (2008) Coincident activity of converging pathways enables simultaneous long-term potentiation and long-term depression in hippocampal CA1 network in vivo. PLoS ONE 3:e2848.
Dong Z, Zhong W, Tian M, Han H, Cao J, Xu T, Luo J, Xu L (2006) Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo. Hippocampus 16:1017-1025.
Doyere V, Debiec J, Monfils MH, Schafe GE, LeDoux JE (2007) Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala. Nat Neurosci 10:414-416.
Dudai Y (1996) Consolidation: fragility on the road to the engrain. Neuron 17:367-370.
Dudai Y, Eisenberg M (2004) Rites of passage of the engram: reconsolidation and the lingering consolidation hypothesis. Neuron 44:93-100.
Dudek SM, Bear MF (1992) Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proc Natl Acad Sci U S A 89:4363-4367.
Dudek SM, Bear MF (1993) Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus. J Neurosci 13:2910-2918.
Dudman JT, Tsay D, Siegelbaum SA (2007) A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity. Neuron 56:866-879.
Ehlers MD (2000) Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron 28:511-525.
Ehrlich I, Malinow R (2004) Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity. J Neurosci 24:916-927.
Eichenbaum H (2004) Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron 44:109-120.
Eichenbaum H, Yonelinas AP, Ranganath C (2007) The medial temporal lobe and recognition memory. Annu Rev Neurosci 30:123-152.
Esteban JA, Shi SH, Wilson C, Nuriya M, Huganir RL, Malinow R (2003) PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nat Neurosci 6:136-143.
Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8:1481-1489.
Floyd NS, Price JL, Ferry AT, Keay KA, Bandler R (2001) Orbitomedial prefrontal cortical projections to hypothalamus in the rat. J Comp Neurol 432:307-328.
Fonseca R, Nagerl UV, Bonhoeffer T (2006) Neuronal activity determines the protein synthesis dependence of long-term potentiation. Nat Neurosci 9:478-480.
Frankland PW, Bontempi B (2005) The organization of recent and remote memories.Nat Rev Neurosci 6:119-130.
Frenois F, Stinus L, Di Blasi F, Cador M, Le Moine C (2005) A specific limbic circuit underlies opiate withdrawal memories. J Neurosci 25:1366-1374.
Fuchs RA, Evans KA, Ledford CC, Parker MP, Case JM, Mehta RH, See RE (2005) The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats.Neuropsychopharmacology 30: 296-309.
Fukunaga K, Muller D, Miyamoto E (1995) Increased phosphorylation of Ca2+/calmodulin-dependent protein kinase II and its endogenous substrates in the induction of long-term potentiation. J Biol Chem 270:6119-6124.
Gabrieli JD, Brewer JB, Desmond JE, Glover GH (1997) Separate neural bases of two fundamental memory processes in the human medial temporal lobe. Science 276:264-266.
Gaffan EA, Healey AN, Eacott MJ (2004) Objects and positions in visual scenes:effects of perirhinal and postrhinal cortex lesions in the rat. Behav Neurosci 118:992-1010.
Gasbarri A, Packard MG, Campana E, Pacitti C (1994) Anterograde and retrograde tracing of projections from the ventral tegmental area to the hippocampal formation in the rat. Brain Res Bull 33:445-452.
Giese KP, Fedorov NB, Filipkowski RK, Silva AJ (1998) Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning.Science 279:870-873.
Gomez LL, Alam S, Smith KE, Home E, Dell'Acqua ML (2002) Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin. J Neurosci 22:7027-7044.
Goto Y, O'Donnell P (2001) Synchronous activity in the hippocampus and nucleus accumbens in vivo. J Neurosci 21 :RC 131.
Goto Y, O'Donnell P (2002) Timing-dependent limbic-motor synaptic integration in the nucleus accumbens. Proc Natl Acad Sci U S A 99:13189-13193.
Grant S, London ED, Newlin DB, Villemagne VL, Liu X, Contoreggi C, Phillips RL,Kimes AS, Margolin A (1996) Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci U S A 93:12040-12045.
Greengard P, Allen PB, Nairn AC (1999) Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 23:435-447.
Greengard P, Nairn AC, Girault JA, Ouimet CC, Snyder GL, Fisone G, Allen PB,Fienberg A, Nishi A (1998) The DARPP-32/protein phosphatase-1 cascade: a model for signal integration. Brain Res Brain Res Rev 26:274-284.
Groenewegen HJ, Wright CI, Beijer AV (1996) The nucleus accumbens: gateway for limbic structures to reach the motor system? Prog Brain Res 107:485-511.
Gurden H, Tassin JP, Jay TM (1999) Integrity of the mesocortical dopaminergic system is necessary for complete expression of in vivo hippocampal-prefrontal cortex long-term potentiation. Neuroscience 94:1019-1027.
Gurden H, Takita M, Jay TM (2000) Essential role of D1 but not D2 receptors in the NMDA receptor-dependent long-term potentiation at hippocampal-prefrontal cortex synapses in vivo. J Neurosci 20:RC106.
Guzowski JF, McGaugh JL (1997) Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training. Proc Natl Acad Sci U S A 94:2693-2698.
Hall J, Parkinson JA, Connor TM, Dickinson A, Everitt BJ (2001) Involvement of the central nucleus of the amygdala and nucleus accumbens core in mediating Pavlovian influences on instrumental behaviour. Eur J Neurosci 13:1984-1992.
Harney SC, Rowan M, Anwyl R (2006) Long-term depression of NMDA receptor-mediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to long-term potentiation by low intracellular calcium buffering. J Neurosci 26:1128-1132.
Harvey J, Lacey MG (1997) A postsynaptic interaction between dopamine D1 and NMDA receptors promotes presynaptic inhibition in the rat nucleus accumbens via adenosine release. J Neurosci 17:5271-5280.
Healy AF, McNamara DS (1996) Verbal learning and memory: does the modal model still work? Annu Rev Psychol 47:143-172.
Hebb DO (1949) The Organization of Behavior: A Neuropsychological Theory. New York: Wiley.
Henke K, Buck A, Weber B, Wieser HG (1997) Human hippocampus establishes associations in memory. Hippocampus 7:249-256.
Hernandez-Lopez S, Bargas J, Surmeier DJ, Reyes A, Galarraga E (1997) D1 receptor activation enhances evoked discharge in neostriatal medium spiny neurons by modulating an L-type Ca2+ conductance. J Neurosci 17:3334-3342.
Hernandez PJ, Kelley AE (2005) Cracking addiction the second time around: reconsolidation of drug-related memories. Neuron 47:772-775.
Herron CE, Lester RA, Coan EJ, Collingridge GL (1986) Frequency-dependent involvement of NMD A receptors in the hippocampus: a novel synaptic mechanism. Nature 322:265-268.
Holland LL, Wagner JJ (1998) Primed facilitation of homosynaptic long-term depression and depotentiation in rat hippocampus. J Neurosci 18:887-894.
Hrabetova S, Sacktor TC (1996) Bidirectional regulation of protein kinase M zeta in the maintenance of long-term potentiation and long-term depression. J Neurosci 16:5324-5333.
Huang Q, Zhou D, Chase K, Gusella JF, Aronin N, DiFiglia M (1992) Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus. Proc Natl Acad Sci U S A 89:11988-11992.
Huang YY, Kandel ER (1995) D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus.Proc Natl Acad Sci U S A 92:2446-2450.
Huang YY, Pittenger C, Kandel ER (2004) A form of long-lasting, learning-related synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing. Proc Natl Acad Sci U S A101:859-864.
Hutcheson DM, Everitt BJ, Robbins TW, Dickinson A (2001) The role of withdrawal in heroin addiction: enhances reward or promotes avoidance? Nat Neurosci 4:943-947.
Hyman SE, Malenka RC, Nestler EJ (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29:565-598.
Ito M, Kano M (1982) Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex. Neurosci Lett 33:253-258.
Ito R, Robbins TW, Pennartz CM, Everitt BJ (2008) Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning. J Neurosci 28:6950-6959.
Ito R, Dalley JW, Howes SR, Robbins TW, Everitt BJ (2000) Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. J Neurosci 20:7489-7495.
Jay TM, Burette F, Laroche S (1995) NMDA receptor-dependent long-term potentiation in the hippocampal afferent fibre system to the prefrontal cortex in the rat. Eur J Neurosci 7:247-250.
Jay TM, Gurden H, Yamaguchi T (1998) Rapid increase in PKA activity during long-term potentiation in the hippocampal afferent fibre system to the prefrontal cortex in vivo. Eur J Neurosci 10:3302-3306.
Jester JM, Campbell LW, Sejnowski TJ (1995) Associative EPSP—spike potentiation induced by pairing orthodromic and antidromic stimulation in rat hippocampal slices. J Physiol 484 (Pt 3):689-705.
Kalia LV, Gingrich JR, Salter MW (2004) Src in synaptic transmission and plasticity.Oncogene 23:8007-8016.
Kalivas PW, Volkow N, Seamans J (2005) Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron 45:647-650.
Kameyama K, Lee HK, Bear MF, Huganir RL (1998) Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression. Neuron 21:1163-1175.
Kandel ER (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294:1030-1038.
Kandel ER, Tauc L (1965) Heterosynaptic facilitation in neurones of the abdominal ganglion of Aplysia depilans. J Physiol 181:1-27.
Kauer JA, Malenka RC (2007) Synaptic plasticity and addiction. Nat Rev Neurosci 8:844-858.
Kelley AE (2004) Memory and addiction: shared neural circuitry and molecular mechanisms. Neuron 44:161 -179.
Kelley AE, Berridge KC (2002) The neuroscience of natural rewards: relevance to addictive drugs. J Neurosci 22:3306-3311.
Kemp A, Manahan-Vaughan D (2007) Hippocampal long-term depression: master or minion in declarative memory processes? Trends Neurosci 30:111-118.
Kim E, Sheng M (2004) PDZ domain proteins of synapses. Nat Rev Neurosci 5:771-781.
Kirkwood A, Bear MF (1994) Homosynaptic long-term depression in the visual cortex. J Neurosci 14:3404-3412.
Kirov SA, Goddard CA, Harris KM (2004) Age-dependence in the homeostatic upregulation of hippocampal dendritic spine number during blocked synaptic transmission. Neuropharmacology 47:640-648.
Kobayashi Y, Ricci A, Amenta F (1994) Autoradiographic localization of dopamine D1-like receptors in the rabbit pulmonary circulation. Eur J Pharmacol 253:201-206.
Konradi C, Leveque JC, Hyman SE (1996) Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium. J Neurosci 16:4231-4239.
Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence.Science 242:715-723.
Koob GF, Heinrichs SC, Menzaghi F, Pich EM, Britton KT (1994) Corticotropin releasing factor, stress and behavior. Semin Neurosci 6: 221-229.
Koob GF, Le Moal M (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278: 52-58.
Koob GF, Le Moal M (2001) Drug addiction, dysregulation of reward, and allostasis.Neuropsychopharmacology 24: 97-129.
Koob GF, Le Moal M (2008) Addiction and the brain antireward system. Annu Rev Psychol 59: 29-53.
Koob GF, Stinus L, Le Moal M, Bloom FE (1989) Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence.Neurosci Biobehav Rev 13:135-140.
Kometsky C, Esposito RU (1979) Euphorigenic drugs: effects on the reward pathways of the brain. Fed Proc 38: 2473-2476.
Krasnova IN, Li SM, Wood WH, McCoy MT, Prabhu W, Becker KG, Katz JL, Cadet JL (2008) Transcriptional responses to reinforcing effects of cocaine in the rat hippocampus and cortex. Genes Brain Behav 7:193-202.
Lattal KM, Abel T (2004) Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time.Proc Natl Acad Sci U S A 101:4667-4672.
Lee FJ, Xue S, Pei L, Vukusic B, Chery N, Wang Y, Wang YT, Niznik HB, Yu XM, Liu F (2002) Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Cell 111:219-230.
Lee HK, Kameyama K, Huganir RL, Bear MF (1998) NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21:1151-1162.
Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL (2000) Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405:955-959.
Lee HK, Takamiya K, Han JS, Man H, Kim CH, Rumbaugh G, Yu S, Ding L, He C,Petralia RS, Wenthold RJ, Gallagher M, Huganir RL (2003) Phosphorylation of the AMPA receptor GluRl subunit is required for synaptic plasticity and retention of spatial memory. Cell 112:631-643.
Lee JL, Everitt BJ, Thomas KL (2004) Independent cellular processes for hippocampal memory consolidation and reconsolidation. Science 304:839-843.
Lee JL, Di Ciano P, Thomas KL, Everitt BJ (2005) Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior. Neuron 47:795-801.
Lemon N, Manahan-Vaughan D (2006) Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. J Neurosci 26:7723-7729.
Levy WB, Steward O (1983) Temporal contiguity requirements for long-term associative potentiation/depression in the hippocampus. Neuroscience 8:791-797.
Li S, Cullen WK, Anwyl R, Rowan MJ (2003) Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty. Nat Neurosci 6:526-531.
Ling DS, Benardo LS, Serrano PA, Blace N, Kelly MT, Crary JF, Sacktor TC (2002) Protein kinase Mzeta is necessary and sufficient for LTP maintenance. Nat Neurosci 5:295-296.
Lisman J (1989) A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proc Natl Acad Sci U S A 86:9574-9578.
Lisman JE, Grace AA (2005) The hippocampal-VTA loop: controlling the entry of information into long-term memory. Neuron 46:703-713.
Liste I, Guerra MJ, Caruncho HJ, Labandeira-Garcia JL (1997) Treadmill running induces striatal Fos expression via NMDA glutamate and dopamine receptors.Exp Brain Res 115:458-468.
Liu L, Wong TP, Pozza MF, Lingenhoehl K, Wang Y, Sheng M, Auberson YP, Wang YT (2004) Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304:1021-1024.
Lledo PM, Hjelmstad GO, Mukherji S, Soderling TR, Malenka RC, Nicoll RA (1995) Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism. Proc Natl Acad Sci U S A 92:11175-11179.
Lu L, Chen H, Su W, Ge X, Yue W, Su F, Ma L (2005) Role of withdrawal in reinstatement of morphine-conditioned place preference. Psychopharmacology (Berl) 181:90-100.
Luscher C, Nicoll RA, Malenka RC, Muller D (2000) Synaptic plasticity and dynamic modulation of the postsynaptic membrane. Nat Neurosci 3:545-550.
Lynch GS, Dunwiddie T, Gribkoff V (1977) Heterosynaptic depression: a postsynaptic correlate of long-term potentiation. Nature 266:737-739.
Lynch MA (2004) Long-term potentiation and memory. Physiol Rev 84:87-136.
Magee JC, Johnston D (1997) A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons. Science 275:209-213.
Maguire EA (2001) Neuroimaging, memory and the human hippocampus. Rev Neurol (Paris) 157:791-794.
Makhinson M, Chotiner JK, Watson JB, O'Dell TJ (1999) Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/calmodulin-dependent kinase II autophosphorylation. J Neurosci 19:2500-2510.
Malenka RC (1991) Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus. Neuron 6:53-60.
Malenka RC (2003) The long-term potential of LTP. Nat Rev Neurosci 4:923-926.
Malenka RC, Nicoll RA (1993) NMDA-receptor-dependent synaptic plasticity:multiple forms and mechanisms. Trends Neurosci 16:521-527.
Malenka RC, Nicoll RA (1999) Long-term potentiation~a decade of progress?Science 285:1870-1874.
Malenka RC, Bear MF (2004) LTP and LTD: an embarrassment of riches. Neuron 44:5-21.
Malinow R, Malenka RC (2002) AMPA receptor trafficking and synaptic plasticity.Annu Rev Neurosci 25:103-126.
Malkova L, Mishkin M (2003) One-trial memory for object-place associations after separate lesions of hippocampus and posterior parahippocampal region in the monkey. J Neurosci 23:1956-1965.
Manns JR, Howard MW, Eichenbaum H (2007) Gradual changes in hippocampal activity support remembering the order of events. Neuron 56:530-540.
Maquet P (2001) The role of sleep in learning and memory. Science 294:1048-1052.
Marder E, Goaillard JM (2006) Variability, compensation and homeostasis in neuron and network function. Nat Rev Neurosci 7:563-574.
Maren S (2001) Neurobiology of Pavlovian fear conditioning. Annu Rev Neurosci 24:897-931.
Marr D (1969) Atheory of cerebellar cortex. J Physiol 202:437-470.
Martin SJ, Grimwood PD, Morris RG (2000) Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci 23:649-711.
Martin SJ, de Hoz L, Morris RG (2005) Retrograde amnesia: neither partial nor complete hippocampal lesions in rats result in preferential sparing of remote spatial memory, even after reminding. Neuropsychologia 43:609-624.
Matsuzaki M, Honkura N, Ellis-Davies GC, Kasai H (2004) Structural basis of long-term potentiation in single dendritic spines. Nature 429:761-766.
Mauk MD, Steinmetz JE, Thompson RF (1986) Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus. Proc Natl Acad Sci U S A 83:5349-5353.
McCormick DA, Thompson RF (1984) Cerebellum: essential involvement in the classically conditioned eyelid response. Science 223:296-299.
McGaugh JL (2000) Memory--a century of consolidation. Science 287:248-251.
McGeorge AJ, Faull RL (1989) The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 29:503-537.
McLellan AT, Lewis DC, O'Brien CP, Kleber HD (2000) Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. Jama 284:1689-1695.
Merlo-Pich E, Lorang M, Yeganeh M, Rodriguez de Fonseca F, Raber J, Koob GF,Weiss F (1995) Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. J Neurosci 15:5439.5447.
Meyers RA, Zavala AR, Speer CM, Neisewander JL (2006) Dorsal hippocampus inhibition disrupts acquisition and expression, but not consolidation, of cocaine conditioned place preference. Behav Neurosci 120:401-412.
Milekic MH, Alberini CM (2002) Temporally graded requirement for protein synthesis following memory reactivation. Neuron 36:521-525.
Miller KD (1996) Synaptic economics: competition and cooperation in synaptic plasticity. Neuron 17:371-374.
Miller CA, Marshall JF (2005) Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory. Neuron 47:873-884.
Montague PR, Hyman SE, Cohen JD (2004) Computational roles for dopamine in behavioural control. Nature 431:760-767.
Montgomery JM, Madison DV (2002) State-dependent heterogeneity in synaptic depression between pyramidal cell pairs. Neuron 33:765-777.
Montgomery JM, Zamorano PL, Garner CC (2004) MAGUKs in synapse assembly and function: an emerging view. Cell Mol Life Sci 61:911-929.
Morishita W,Connor JH,Xia H,Quinlan EM,Shenolikar S,Malenka RC(2001)Regulation of synaptic strength by protein phosphatase 1.Neuron 32:1133-1148.
Morishita W,Lu W,Smith GB,Nicoll RA,Bear MF,Malenka RC(2007) Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression.Neuropharmacology 52:71-76.
Morris RG(2001) Episodic-like memory in animals:psychological criteria,neural mechanisms and the value of episodic-like tasks to investigate animal models of neurodegenerative disease.Philos Trans R Soc Lond B Biol Sci 356:1453-1465.
Morris RG,Anderson E,Lynch GS,Baudry M(1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist,AP5.Nature 319:774-776.
Morris RG,Moser EI,Riedel G,Martin SJ,Sandin J,Day M,O'Carroll C(2003)Elements of a neurobiological theory of the hippocampus:the role of activity-dependent synaptic plasticity in memory.Philos Trans R Soc Lond B Biol Sci 358:773-786.
Mulkey RM,Malenka RC(1992) Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus.Neuron 9:967-975.
Mulkey RM,Herron CE,Malenka RC(1993) An essential role for protein phosphatases in hippocampal long-term depression.Science 261:1051-1055.
Mulkey RM,Endo S,Shenolikar S,Malenka RC(1994) Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression.Nature 369:486-488.
Myers KM,Davis M(2002) Systems-level reconsolidation:reengagement of the hippocampus with memory reactivation.Neuron 36:340-343.
Nader K(2003) Memory traces unbound.Trends Neurosci 26:65-72.
Nader K,Hardt O(2009) A single standard for memory:the case for reconsolidation.Nat Rev Neurosci 10:224-234.
Nader K,Schafe GE,Le Doux JE(2000) Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval.Nature 406:722-726.
Nestler EJ,Aghajanian GK(1997) Molecular and cellular basis of addiction.Science 278:58-63.
Nestler,EJ(2008) Transcriptional mechanisms of addiction:role of △FosB.Philos Trans R Soc Lond B Bio Sci 363:3245-3255.
Neves G,Cooke SF,Bliss TV(2008) Synaptic plasticity,memory and the hippocampus:a neural network approach to causality.Nat Rev Neurosci 9:65-75.
Nevian T,Sakmann B(2006) Spine Ca2+ signaling in spike-timing-dependent plasticity.J Neurosci 26:11001-11013.
Nicoll RA,Kauer JA,Malenka RC(1988) The current excitement in long-term potentiation.Neuron 1:97-103.
Nicoll RA,Tomita S,Bredt DS(2006) Auxiliary subunits assist AMPA-type glutamate receptors.Science 311:1253-1256.
Nishiyama M, Hong K, Mikoshiba K, Poo MM, Kato K (2000) Calcium stores regulate the polarity and input specificity of synaptic modification. Nature 408:584-588.
Norman G, Eacott MJ (2005) Dissociable effects of lesions to the perirhinal cortex and the postrhinal cortex on memory for context and objects in rats. Behav Neurosci 119:557-566.
O'Brien CP, Childress AR, Ehrman R, Robbins SJ (1998) Conditioning factors in drug abuse: can they explain compulsion? J Psychopharmacol 12:15-22.
O'Carroll CM, Martin SJ, Sandin J, Frenguelli B, Morris RG (2006) Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory.Learn Mem 13:760-769.
O'Doherty J, Dayan P, Schultz J, Deichmann R, Friston K, Dolan RJ (2004) Dissociable roles of ventral and dorsal striatum in instrumental conditioning.Science 304:452-454.
O'Keefe J (1993) Hippocampus, theta, and spatial memory. Curr Opin Neurobiol 3:917-924.
Oh MC, Derkach VA (2005) Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII. Nat Neurosci 8:853-854.
Olive MF, Koenig HN, Nannini MA, Hodge CW (2002) Elevated extracellularCRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake. Pharmacol Biochem Behav 72:213-220.
Pacheco-Cano MT, Bargas J, Hernandez-Lopez S, Tapia D, Galarraga E (1996) Inhibitory action of dopamine involves a subthreshold Cs(+)-sensitive conductance in neostriatal neurons. Exp Brain Res 110:205-211.
Park M, Penick EC, Edwards JG, Kauer JA, Ehlers MD (2004) Recycling endosomes supply AMPA receptors for LTP. Science 305:1972-1975.
Parkinson JA, Olmstead MC, Burns LH, Robbins TW, Everitt BJ (1999) Dissociation in effects of lesions of the nucleus accumbens core and shell on appetitive pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by D-amphetamine. J Neurosci 19:2401-2411.
Parkinson JA, Dalley JW, Cardinal RN, Bamford A, Fehnert B, Lachenal G,Rudarakanchana N, Halkerston KM, Robbins TW, Everitt BJ (2002) Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function. Behav Brain Res 137:149-163.
Pastalkova E, Serrano P, Pinkhasova D, Wallace E, Fenton AA, Sacktor TC (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313:1141-1144.
Paterson NE, Myers C, Markou A (2000) Effects of repeated withdrawal from continuous amphetamine administration on brain reward function in rats.Psychopharmacology 152: 440-446.
Paulson PE, Camp DM, Robinson TE (1991) Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats.Psychopharmacology (Berl) 103:480-492.
Pavlov I (1927) Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex.. London: Oxford University.
Pei L, Lee FJ, Moszczynska A, Vukusic B, Liu F (2004) Regulation of dopamine D1 receptor function by physical interaction with the NMDA receptors. J Neurosci 24:1149-1158.
Pettit DL, Perlman S, Malinow R (1994) Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons. Science 266:1881-1885.
Piazza PV, Le Moal ML (1996) Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annu Rev Pharmacol Toxicol 36:359-378.
Pu L, Bao GB, Xu NJ, Ma L, Pei G (2002) Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates. J Neurosci 22:1914-1921.
Qi YL, Adler J (1989) Salt taxis in Escherichia coli bacteria and its lack in mutants. Proc Natl Acad Sci U S A 86:8358-8362.
Rasmussen DD, Boldt BM, Bryant CA, Mitton DR, Larsen SA, Wilkinson CW (2000) Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo- pituitary-adrenal axis. Alcohol Clin Exp Res 24: 1836-1849.
Rescorla RA (1994) Control of instrumental performance by Pavlovian and instrumental stimuli. J Exp Psychol Anim Behav Process 20:44-50.
Reymann KG, Frey JU (2007) The late maintenance of hippocampal LTP:requirements, phases, 'synaptic tagging', 'late-associativity' and implications.Neuropharmacology 52:24-40.
Rivier C, Bruhn T, Vale W (1984) Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF). J Pharmacol Exp Ther. 229: 127-131.
Robbins TW, Everitt BJ (2002) Limbic-striatal memory systems and drug addiction.Neurobiol Learn Mem 78:625-636.
Robinson TE, Becker JB (1986) Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res 396:157-198.
Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247-291.
Robinson TE, Berridge KC (2003) Addiction. Annu Rev Psychol 54:25-53.
Royer S, Pare D (2003) Conservation of total synaptic weight through balanced synaptic depression and potentiation. Nature 422:518-522.
Rumpel S, LeDoux J, Zador A, Malinow R (2005) Postsynaptic receptor trafficking underlying a form of associative learning. Science 308:83-88.
Sajikumar S, Frey JU (2004) Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD. Neurobiol Learn Mem 82:12-25.
Sajikumar S, Navakkode S, Sacktor TC, Frey JU (2005) Synaptic tagging and cross-tagging: the role of protein kinase Mzeta in maintaining long-term potentiation but not long-term depression. J Neurosci 25:5750-5756.
Scanziani M, Malenka RC, Nicoll RA (1996) Role of intercellular interactions in heterosynaptic long-term depression. Nature 380:446-450.
Schafe GE, LeDoux JE (2000) Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. J Neurosci 20:RC96.
Schenk S, Partridge B (2000) Sensitization to cocaine's reinforcing effects produced by various cocaine pretreatment regimens in rats. Pharmacol Biochem Behav 66:765-770.
Schmidt HD, Anderson SM, Pierce RC (2006) Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat. Eur J Neurosci 23:219-228.
Schmidt HD, Anderson SM, Famous KR, Kumaresan V, Pierce RC (2005) Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking.Eur J Pharmacol 526:65-76.
Schoenbaum G, Chiba AA, Gallagher M (2000) Changes in functional connectivity in orbitofrontal cortex and basolateral amygdala during learning and reversal training. J Neurosci 20:5179-5189.
Schulteis G, Ahmed SH, Morse AC, Koob GF, Everitt BJ (2000) Conditioning and opiate withdrawal. Nature 405:1013-1014.
Schultz W (2006) Behavioral theories and the neurophysiology of reward. Annu Rev Psychol 57:87-115.
Schultz W, Dickinson A (2000) Neuronal coding of prediction errors. Annu Rev Neurosci 23:473-500.
Scott L, Kruse MS, Forssberg H, Brismar H, Greengard P, Aperia A (2002) Selective up-regulation of dopamine Dl receptors in dendritic spines by NMDA receptor activation. Proc Natl Acad Sci U S A 99:1661-1664.
Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20:11-21.
Serrano P, Yao Y, Sacktor TC (2005) Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation. J Neurosci 25:1979-1984.
Sesack SR, Pickel VM (1990) In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other. Brain Res 527:266-279.
Sheng M, Kim MJ (2002) Postsynaptic signaling and plasticity mechanisms. Science 298:776-780.
Shimizu E, Tang YP, Rampon C, Tsien JZ (2000) NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science 290:1170-1174.
Siegel JM (2001) The REM sleep-memory consolidation hypothesis. Science 294:1058-1063.
Silva AJ, Paylor R, Wehner JM, Tonegawa S (1992) Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257:206-211.
Silva AJ, Kogan JH, Frankland PW, Kida S (1998) CREB and memory. Annu Rev Neurosci 21:127-148.
Smith-Roe SL, Kelley AE (2000) Coincident activation of NMD A and dopamine D1 receptors within the nucleus accumbens core is required for appetitive instrumental learning. J Neurosci 20:7737-7742.
Smith WB, Starck SR, Roberts RW, Schuman EM (2005) Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron 45:765-779.
Snyder EM, Colledge M, Crozier RA, Chen WS, Scott JD, Bear MF (2005) Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression. J Biol Chem 280:16962-16968.
Solomon RL (1980) The opponent-process theory of acquired motivation: the costs of pleasure and the benefits of pain. Am Psychol 35:691-712.
Solomon RL, Corbit JD (1974) An opponent-process theory of motivation: 1.Temporal dynamics of affect. Psychol Rev 81: 119-145.
Song I, Huganir RL (2002) Regulation of AMPA receptors during synaptic plasticity.Trends Neurosci 25:578-588.
Squire LR, Alvarez P (1995) Retrograde amnesia and memory consolidation: a neurobiological perspective. Curr Opin Neurobiol 5:169-177.
Staubli U, Lynch G (1987) Stable hippocampal long-term potentiation elicited by 'theta' pattern stimulation. Brain Res 435:227-234.
Staubli U, Lynch G (1990) Stable depression of potentiated synaptic responses in the hippocampus with 1-5 Hz stimulation. Brain Res 513:113-118.
Stein V, House DR, Bredt DS, Nicoll RA (2003) Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression. J Neurosci 23:5503-5506.
Steiner H, Kitai ST (2000) Regulation of rat cortex function by Dl dopamine receptors in the striatum. J Neurosci 20:5449-5460.
Steward O, Worley PF (2001a) A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites. Proc Natl Acad Sci U S A 98:7062-7068.
Steward O, Worley PF (2001b) Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron 30:227-240.
Stewart J, de Wit H, Eikelboom R (1984) Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol Rev 91:251-268.
Stickgold R, Hobson JA, Fosse R, Fosse M (2001) Sleep, learning, and dreams:off-line memory reprocessing. Science 294:1052-1057.
Sutton MA, Schuman EM (2006) Dendritic protein synthesis, synaptic plasticity, and memory. Cell 127:49-58.
Sweatt JD (2004) Mitogen-activated protein kinases in synaptic plasticity and memory.Curr Opin Neurobiol 14:311-317.
Thomas GM, Huganir RL (2004) MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci 5:173-183.
Thompson AM, Gosnell BA, Wagner JJ (2002) Enhancement of long-term potentiation in the rat hippocampus following cocaine exposure.Neuropharmacology 42:1039-1042.
Thompson AM, Swant J, Gosnell BA, Wagner JJ (2004) Modulation of long-term potentiation in the rat hippocampus following cocaine self-administration.Neuroscience 127:177-185.
Thorsell A, Rapunte-Canonigo V, O'Dell L, Chen SA, King A, Lekic D, Koob G F,Sanna PP (2007) Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. Brain 130:1330-1337.
Tiffany ST (1990) A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. Psychol Rev 97:147-168.
Tong ZY, Overton PG, Clark D (1995) Chronic administration of (+)-amphetamine alters the reactivity of midbrain dopaminergic neurons to prefrontal cortex stimulation in the rat. Brain Res 674:63-74.
Totterdell S, Smith AD (1989) Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat. J Chem Neuroanat 2:285-298.
Tronson NC, Taylor JR (2007) Molecular mechanisms of memory reconsolidation.Nat Rev Neurosci 8:262-275.
Trujillo KA, Akil H (1991) Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251:85-87.
Tse D, Langston RF, Kakeyama M, Bethus I, Spooner PA, Wood ER, Witter MP,Morris RG (2007) Schemas and memory consolidation. Science 316:76-82.
Tsien JZ, Huerta PT, Tonegawa S (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87:1327-1338.
Tsumoto T (1993) Long-term depression in cerebral cortex: a possible substrate of "forgetting" that should not be forgotten. Neurosci Res 16:263-270.
Tulving E (2002) Episodic memory: from mind to brain. Annu Rev Psychol 53:1-25.
Turrigiano GG (2008) The self-tuning neuron: synaptic scaling of excitatory synapses. Cell 135:422-435.
Turrigiano GG, Nelson SB (2004) Homeostatic plasticity in the developing nervous system. Nat Rev Neurosci 5:97-107.
Turrigiano GG, Leslie KR, Desai NS, Rutherford LC, Nelson SB (1998) Activity-dependent scaling of quantal amplitude in neocortical neurons.Nature 391:892-896.
Tzschentke TM (1998) Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 56:613-672.
Tzschentke TM, Schmidt WJ (2003) Glutamatergic mechanisms in addiction. Mol Psychiatry 8:373-382.
Valjent E, Corvol JC, Pages C, Besson MJ, Maldonado R, Caboche J (2000) Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. J Neurosci 20:8701-8709.
Vezina P (2004) Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs. Neurosci Biobehav Rev 27:827-839.
Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL (2001) Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science 292:1175-1178.
Wang J, O'Donnell P (2001) D(l) dopamine receptors potentiate nmda-mediated excitability increase in layer V prefrontal cortical pyramidal neurons. Cereb Cortex 11:452-462.
Wang JQ, Daunais JB, McGinty JF (1994) NMDA receptors mediate amphetamine-induced upregulation of zif/268 and preprodynorphin mRNA expression in rat striatum. Synapse 18:343-353.
Wang XY, Zhao M, Ghitza UE, Li YQ, Lu L (2008) Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala. J Neurosci 28:5602-5610.
Wang Z, Xu NL, Wu CP, Duan S, Poo MM (2003) Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications. Neuron 37:463-472.
Watanabe S, Hoffman DA, Migliore M, Johnston D (2002) Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A 99:8366-8371.
Weiss F, Markou A, Lorang MT, Koob GF (1992) Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. Brain Res 593: 314-318.
Weiss F, Parsons LH, Schulteis G, Hyytia P, Lorang MT, Bloom FE, Koob GF (1996) Ethanol selfadministration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. J Neurosci. 16: 3474-3485.
Wenthold RJ, Petralia RS, Blahos J, II, Niedzielski AS (1996) Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons. J Neurosci 16:1982-1989.
Whitlock JR, Heynen AJ, Shuler MG, Bear MF (2006) Learning induces long-term potentiation in the hippocampus. Science 313:1093-1097.
Wilder A (1948) Recent progress in research on the neurophysiological basis of morphine addiction. Am J Psychiatry 105:329-38.
Wilder A (1973) Dynamics of drug dependence. Implications of a conditioning theory for research and treatment. Arch Gen Psychiatry 28:611-616.
Wilder A, Pescor FT (1967) Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and "relapse" in morphine-addicted rats. Psychopharmacologia 10:255-284.
Will MJ, Franzblau EB, Kelley AE (2004) The amygdala is critical for opioid-mediated binge eating of fat. Neuroreport 15:1857-1860.
Wittenberg GM, Tsien JZ (2002) An emerging molecular and cellular framework for memory processing by the hippocampus. Trends Neurosci 25:501-505.
Wittenberg GM, Sullivan MR, Tsien JZ (2002) Synaptic reentry reinforcement based network model for long-term memory consolidation. Hippocampus 12:637-647.
Witter MP, Groenewegen HJ, Lopes da Silva FH, Lohman AH (1989) Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region. Prog Neurobiol 33:161-253.
Wolf ME (1998) The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54:679-720.
Wu J, Rush A, Rowan MJ, Anwyl R (2001) NMDA receptor- and metabotropic glutamate receptor-dependent synaptic plasticity induced by high frequency stimulation in the rat dentate gyrus in vitro. J Physiol 533:745-755.
Xu L, Anwyl R, Rowan MJ (1997) Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature 387:497-500.
Xu L, Anwyl R, Rowan MJ (1998) Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus. Nature 394:891-894.
Yang Y, Zheng X, Wang Y, Cao J, Dong Z, Cai J, Sui N, Xu L (2004) Stress enables synaptic depression in CAI synapses by acute and chronic morphine: possible mechanisms for corticosterone on opiate addiction. J Neurosci 24:2412-2420.
Yeckel MF, Berger TW (1990) Feedforward excitation of the hippocampus by afferents from the entorhinal cortex: redefinition of the role of the trisynaptic pathway. Proc Natl Acad Sci U S A 87:5832-5836.
Young JZ, Isiegas C, Abel T, Nguyen PV (2006) Metaplasticity of the late-phase of long-term potentiation: a critical role for protein kinase A in synaptic tagging.Eur J Neurosci 23:1784-1794.
Yuste R, Bonhoeffer T (2001) Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci 24:1071-1089.
Zarrindast MR, Azami BN, Rostami P, Rezayof A (2006) Repeated administration of dopaminergic agents in the nucleus accumbens and morphine-induced place preference. Behav Brain Res 169:248-255.
Zhou Y, Wu H, Li S, Chen Q, Cheng XW, Zheng J, Takemori H, Xiong ZQ (2006) Requirement of TORC1 for late-phase long-term potentiation in the hippocampus. PLoS ONE 1:e16.
Ahmed SH,Walker JR,Koob GF(2000) Persistent increase in the motivation to take heroin in rats with a history of drug escalation.Neuropsychopharmacology 22:413-421.
Anagnostaras SG,Robinson TE(1996) Sensitization to the psychomotor stimulant effects of amphetamine:modulation by associative learning.Behav Neurosci 110:1397-1414.
Anderson SM,Bari AA,Pierce RC(2003) Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats. Psychopharmacology (Berl) 168:132-138.
Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE,Terwilliger EF, Cha JH, Pierce RC (2008) CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nat Neurosci 11:344-353.
Bachtell RK, Whisler K, Karanian D, Self DW (2005) Effects of intra-nucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat. Psychopharmacology (Berl) 183:41-53.
Bardo MT (1998) Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Crit Rev Neurobiol 12:37-67.
Berke JD (2003) Learning and memory mechanisms involved in compulsive drug use and relapse. Methods Mol Med 79:75-101.
Berke JD, Hyman SE (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25:515-532.
Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28:309-369.
Bissiere S, Humeau Y, Luthi A (2003) Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition. Nat Neurosci 6:587-592.
Bonci A, Malenka RC (1999) Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area. J Neurosci 19:3723-3730.
Borgland SL, Malenka RC, Bonci A (2004) Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area:electrophysiological and behavioral correlates in individual rats. J Neurosci 24:7482-7490.
Brebner K, Wong TP, Liu L, Liu Y, Campsall P, Gray S, Phelps L, Phillips AG, Wang YT (2005) Nucleus accumbens long-term depression and the expression of behavioral sensitization. Science 310:1340-1343.
Cannon CM, Palmiter RD (2003) Reward without dopamine. J Neurosci 23:10827-10831.
Cardinal RN, Parkinson JA, Hall J, Everitt BJ (2002) Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 26:321-352.
Chao J, Nestler EJ (2004) Molecular neurobiology of drug addiction. Annu Rev Med 55:113-132.
Childress AR, Hole AV, Ehrman RN, Robbins SJ, McLellan AT, O'Brien CP (1993) Cue reactivity and cue reactivity interventions in drug dependence. NIDA Res Monogr 137:73-95.
Chklovskii DB, Mel BW, Svoboda K (2004) Cortical rewiring and information storage. Nature 431:782-788.
Cole RL, Konradi C, Douglass J, Hyman SE (1995) Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14:813-823.
Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng LJ, Shaham Y, Marinelli M,Wolf ME (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118-121.
Das S, Grunert M, Williams L, Vincent SR (1997) NMDA and D1 receptors regulate the phosphorylation of CREB and the induction of c-fos in striatal neurons in primary culture. Synapse 25:227-233.
Derkach VA, Oh MC, Guire ES, Soderling TR (2007) Regulatory mechanisms of AMPA receptors in synaptic plasticity. Nat Rev Neurosci 8:101-113.
Di Chiara G (1998) A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use. J Psychopharmacol 12:54-67.
Dong Y, Saal D, Thomas M, Faust R, Bonci A, Robinson T, Malenka RC (2004) Cocaine-induced potentiation of synaptic strength in dopamine neurons:behavioral correlates in GluRA(-/-) mice. Proc Natl Acad Sci U S A 101:14282-14287.
Dong Z, Zhong W, Tian M, Han H, Cao J, Xu T, Luo J, Xu L (2006) Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo. Hippocampus 16:1017-1025.
Everitt BJ, Wolf ME (2002) Psychomotor stimulant addiction: a neural systems perspective. J Neurosci 22:3312-3320.
Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction:from actions to habits to compulsion. Nat Neurosci 8:1481-1489.
Everitt BJ, Parkinson JA, Olmstead MC, Arroyo M, Robledo P, Robbins TW (1999) Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems. Ann N Y Acad Sci 877:412-438.
Floyd NS, Price JL, Ferry AT, Keay KA, Bandler R (2001) Orbitomedial prefrontal cortical projections to hypothalamus in the rat. J Comp Neurol 432:307-328.
Fourgeaud L, Mato S, Bouchet D, Hemar A, Worley PF, Manzoni OJ (2004) A single in vivo exposure to cocaine abolishes endocannabinoid-mediated long-term depression in the nucleus accumbens. J Neurosci 24:6939-6945.
Greengard P, Nairn AC, Girault JA, Ouimet CC, Snyder GL, Fisone G, Allen PB,Fienberg A, Nishi A (1998) The DARPP-32/protein phosphatase-1 cascade: a model for signal integration. Brain Res Brain Res Rev 26:274-284.
Gurden H, Tassin JP, Jay TM (1999) Integrity of the mesocortical dopaminergic system is necessary for complete expression of in vivo hippocampal-prefrontal cortex long-term potentiation. Neuroscience 94:1019-1027.
Harris GC, Aston-Jones G (2003) Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment. Neuropsychopharmacology 28:73-76.
Hoffman AF, Oz M, Caulder T, Lupica CR (2003) Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. J Neurosci 23:4815-4820.
Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, Nakabeppu Y, Duman RS,Nestler EJ (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13:1235-1244.
Huang YY, Kandel ER (1995) D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus.Proc Natl Acad Sci U S A 92:2446-2450.
Huang YY, Simpson E, Kellendonk C, Kandel ER (2004) Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors. Proc Natl Acad Sci U S A 101:3236-3241.
Hyman SE (2005) Addiction: a disease of learning and memory. Am J Psychiatry 162:1414-1422.
Hyman SE, Malenka RC (2001) Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci 2:695-703.
Hyman SE, Malenka RC, Nestler EJ (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29:565-598.
Jones S, Kornblum JL, Kauer JA (2000) Amphetamine blocks long-term synaptic depression in the ventral tegmental area. J Neurosci 20:5575-5580.
Kalivas PW (2004) Glutamate systems in cocaine addiction. Curr Opin Pharmacol 4:23-29.
Kalivas PW, Weber B (1988) Amphetamine injection into the ventral mesencephalon sensitizes rats to peripheral amphetamine and cocaine. J Pharmacol Exp Ther 245:1095-1102.
Kalivas PW, Volkow N, Seamans J (2005) Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron 45:647-650.
Kauer JA (2004) Learning mechanisms in addiction: synaptic plasticity in the ventral tegmental area as a result of exposure to drugs of abuse. Annu Rev Physiol 66:447-475.
Kauer JA, Malenka RC (2007) Synaptic plasticity and addiction. Nat Rev Neurosci 8:844-858.
Kelley AE (2004) Memory and addiction: shared neural circuitry and molecular mechanisms. Neuron 44:161-179.
Kim HS, Park WK, Jang CG, Oh S (1996) Inhibition by MK-801 of cocaine-induced sensitization, conditioned place preference, and dopamine-receptor supersensitivity in mice. Brain Res Bull 40:201-207.
Konradi C, Leveque JC, Hyman SE (1996) Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium. J Neurosci 16:4231-4239.
Liste I, Guerra MJ, Caruncho HJ, Labandeira-Garcia JL (1997) Treadmill running induces striatal Fos expression via NMDA glutamate and dopamine receptors.Exp Brain Res 115:458-468.
Lonze BE, Ginty DD (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35:605-623.
Malenka RC (2003) The long-term potential of LTP. Nat Rev Neurosci 4:923-926.
Malenka RC, Bear MF (2004) LTP and LTD: an embarrassment of riches. Neuron 44:5-21.
Martin SJ, Grimwood PD, Morris RG (2000) Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci 23:649-711.
Mato S, Chevaleyre V, Robbe D, Pazos A, Castillo PE, Manzoni OJ (2004) A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity. Nat Neurosci 7:585-586.
Matsumoto K, Suzuki W, Tanaka K (2003) Neuronal correlates of goal-based motor selection in the prefrontal cortex. Science 301:229-232. .
McFarland K, Lapish CC, Kalivas PW (2003) Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 23:3531-3537.
Miller EK, Cohen JD (2001) An integrative theory of prefrontal cortex function. Annu Rev Neurosci 24:167-202.
Montague PR, Dayan P, Sejnowski TJ (1996) A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J Neurosci 16:1936-1947.
Montague PR, Hyman SE, Cohen JD (2004) Computational roles for dopamine in behavioural control. Nature 431:760-767.
Morris RG, Moser EI, Riedel G, Martin SJ, Sandin J, Day M, O'Carroll C (2003) Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory. Philos Trans R Soc Lond B Biol Sci 358:773-786.
Nasif FJ, Sidiropoulou K, Hu XT, White FJ (2005) Repeated cocaine administration increases membrane excitability of pyramidal neurons in the rat medial prefrontal cortex. J Pharmacol Exp Ther 312:1305-1313.
Nestler EJ (2002) Common molecular and cellular substrates of addiction and memory. Neurobiol Learn Mem 78:637-647.
O'Brien CP, Childress AR, Ehrman R, Robbins SJ (1998) Conditioning factors in drug abuse: can they explain compulsion? J Psychopharmacol 12:15-22.
Otani S, Blond O, Desce JM, Crepel F (1998) Dopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex. Neuroscience 85:669-676.
Otmakhova NA, Lisman JE (1996) D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses. J Neurosci 16:7478-7486.
Perth HO, Ettenberg A, Bloom FE, Koob GF (1984) Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology (Berl) 84:167-173.
Pu L, Bao GB, Xu NJ, Ma L, Pei G (2002) Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates. J Neurosci 22:1914-1921.
Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247-291.
Robinson TE, Berridge KC (2003) Addiction. Annu Rev Psychol 54:25-53.
Roesch MR, Olson CR (2004) Neuronal activity related to reward value and motivation in primate frontal cortex. Science 304:307-310.
Rolls ET (2004) The functions of the orbitofrontal cortex. Brain Cogn 55:11-29.
Saal D, Dong Y, Bonci A, Malenka RC (2003) Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 37:577-582.
Schmidt HD, Anderson SM, Pierce RC (2006) Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat. Eur J Neurosci 23:219-228.
Schmidt HD, Anderson SM, Famous KR, Kumaresan V, Pierce RC (2005) Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking.Eur J Pharmacol 526:65-76.
Schoenbaum G, Roesch M (2005) Orbitofrontal cortex, associative learning, and expectancies. Neuron 47:633-636.
Schoenbaum G, Chiba AA, Gallagher M (2000) Changes in functional connectivity in orbitofrontal cortex and basolateral amygdala during learning and reversal training. J Neurosci 20:5179-5189.
Schultz W (1998) Predictive reward signal of dopamine neurons. J Neurophysiol 80:1-27.
Schultz W (2006) Behavioral theories and the neurophysiology of reward. Annu Rev Psychol 57:87-115.
Schultz W, Apicella P, Ljungberg T (1993) Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task. J Neurosci 13:900-913.
Schultz W, Dayan P, Montague PR (1997) A neural substrate of prediction and reward.Science 275:1593-1599.
Schultz W, Dickinson A (2000) Neuronal coding of prediction errors. Annu Rev Neurosci 23:473-500.
Sesack SR, Pickel VM (1990) In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other. Brain Res 527:266-279.
Silva AJ, Kogan JH, Frankland PW, Kida S (1998) CREB and memory. Annu Rev Neurosci 21:127-148.
Steiner H, Gerfen CR (1996) Dynorphin regulates D1 dopamine receptor-mediated responses in the striatum: relative contributions of pre- and postsynaptic mechanisms in dorsal and ventral striatum demonstrated by altered immediate-early gene induction. J Comp Neurol 376:530-541.
Steiner H, Kitai ST (2000) Regulation of rat cortex function by Dl dopamine receptors in the striatum. J Neurosci 20:5449-5460.
Steward O, Worley PF (2001a) Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron 30:227-240.
Steward O, Worley PF (2001b) A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites. Proc Natl Acad Sci U S A 98:7062-7068.
Thomas MJ, Malenka RC, Bonci A (2000) Modulation of long-term depression by dopamine in the mesolimbic system. J Neurosci 20:5581-5586.
Thomas MJ, Beurrier C, Bonci A, Malenka RC (2001) Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine.Nat Neurosci 4:1217-1223.
Thompson AM, Gosnell BA, Wagner JJ (2002) Enhancement of long-term potentiation in the rat hippocampus following cocaine exposure.Neuropharmacology 42:1039-1042.
Thompson AM, Swant J, Gosnell BA, Wagner JJ (2004) Modulation of long-term potentiation in the rat hippocampus following cocaine self-administration.Neuroscience 127:177-185.
Tiffany ST (1990) A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. Psychol Rev 97:147-168.
Totterdell S, Smith AD (1989) Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat. J Chem Neuroanat 2:285-298.
Ungless MA, Whistler JL, Malenka RC, Bonci A (2001) Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411:583-587.
Vanderschuren LJ, Kalivas PW (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology (Berl) 151:99-120.
Vanderschuren LJ, Di Ciano P, Everitt BJ (2005) Involvement of the dorsal striatum in cue-controlled cocaine seeking. J Neurosci 25:8665-8670.
Vezina P, Stewart J (1990) Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects. Brain Res 516:99-106.
Wang JQ, Daunais JB, McGinty JF (1994) NMDA receptors mediate amphetamine-induced upregulation of zif/268 and preprodynorphin mRNA expression in rat striatum. Synapse 18:343-353.
Wilder A (1973) Dynamics of drug dependence. Implications of a conditioning theory for research and treatment. Arch Gen Psychiatry 28:611-616.
Will MJ, Franzblau EB, Kelley AE (2004) The amygdala is critical for opioid-mediated binge eating of fat. Neuroreport 15:1857-1860.
Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469-492.
Wolf ME (1998) The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54:679-720.