羊干酪性淋巴结炎诊断方法的研究
|
摘要
绵羊和山羊干酪性淋巴结炎（caseous lymphadenitis in sheep and goat ，简
称 CLA）也称绵羊和山羊假（伪）结核病（pseudotuberculosis in sheep and goat），
是由假（伪）结核棒状杆菌（Corynebacterium pseudotuberculosis）引起的一种
人畜共患的慢性传染病。伪结核棒状杆菌能使绵羊、山羊、骆驼、马、牛等多种动物
致病，发病特征是受害动物的淋巴结肿大，呈脓性干酪性坏死；有的在肺、肝、脾和
子宫角发生大小不等的结节，内含淡黄色干酪样物质。病羊消瘦，生产性能下降，患
病孕羊产出死胎，严重者死亡。由于该病发病缓慢，致死率低，所以常被人们忽视，
发病后用抗生素治疗效果也不佳，所以现在各个国家都对该病的预防、治疗、检测都
重视起来。
分别从杨凌 2 个羊场的 2 只羊的肩前淋巴结脓肿内分离了 2 株菌，经分离鉴定为
假（伪）结核棒状杆菌，记为菌株 A、菌株 B。购买 16 只健康山羊，随机分为 4 组，
菌株 A 复制病例 1 组，菌株 B 复制病例 1 组，标准菌株接种 1 组，空白对照 1 组。从
杨凌养羊场和养羊农户采集了 100 份羊的血清，作为待检血清。用标准菌株制成灭活
苗，免疫 1 只山羊，采集其血液，分离血清，即为阳性血清。将临床健康和菌体凝集
抑制试验阴性羊的剖腹产胎儿的血清作为阴性血清。
将标准菌株（ATCC19410 株）接种灭菌好的含 0.2%吐温-80 的马丁肉汤中，37℃
培养 7d 后制成凝集抑制试验抗原，采集 4 组试验组羊的血清，做菌体凝集抑制试验，
只有空白对照组对该菌原有的凝集不抑制，其他 3 组均能抑制凝集。用待检血清做菌
体凝集抑制试验，同时设置阴性对照和阳性对照，若假（伪）结核棒状杆菌原有的凝
集被抑制，则试验阳性，否则为阴性。
将标准菌株（ATCC19410 株）接种于灭菌好的含 0.2%吐温-80 的马丁肉汤中，振
荡培养 3d，离心，上清液用滤器滤过，制成外毒素抗原，通过 ELISA 酶标抗体和阳
性血清最适浓度的选择、外毒素抗原和阳性血清最适浓度的选择试验，选用适当的抗
原、抗体、酶标抗体浓度，设立空白孔、阳性孔、阴性孔做待检血清的 ELISA 试验，
得出阳性判定值，若待检血清 OD 值大于阴性血清的临界值，则判为阳性，否则判为
阴性。
用建立的菌体凝集抑制试验和 ELISA 方法检测 100 份待检羊血清，得到了相同的
结果,检测到阳性羊 4 只，阳性检出率为 4％。
Caseous lymphadenitis in sheep and goat (CLA) caused by Corynebaterium
Pseudotuberlosis which could infect sheep, goat, camelpa, horse, bovine and so on, is a
kind of zoonotic and chronic infectious. Infected sheep appeared lymphondus
swell,suppurative and caseous necrosis,emerging tubercles in lungs,spleen,uterus horn.
Reduce of production and occur of dead fetus in infecred pregnant sheep.The occur of the
disease was slow and lethal rate low.After infection,effect of antibictic treatment to it was
not good.So every country was increasing attaching importance to prevention theraphy
examina- tion of the disease.
2 bacteria were respectively separated from 2 sheep of Yangling’s 2 sheep-farms in
preshoulder lymphonolus abscess,and identified as Corynebate- rium
Pseudotuberlosis,marked as A and B.16 healthy goats were respectively divided into 4
groups.3 groups were respectively infected bacA bacBand standard Corynebaterium
Pseudotuberlosis,and 4th group as control group.100 sheep sera were collected from
Yangling as samples.Before one month vaccining one goat by sterilized vaccine made by
standard Corynebaterium Pseudotuberlo- s is,we collected serum as negative serum. We
use clinical health goat seras or somatic inhibited agglutination test negative goat cesarean
section fetus seras as negative seras.
Corynebaterium Pseudotuberlosis ATCC19410 was seeded into sterilized Martin-meat
extract including 0.2% tween-80,cultured in 37℃.7 days later, harvested and made into
antigen of agglutination-inhibition test. Sera were collected from 4 groups,except control
group sera,other 3 groups sera all inhibited agglutination of the bacterium.Collecting
examinee’s sera ,we did agglutination-inhibition test meanwhile setting negative and
positive contrast.If Corynebaterium Pseudotuberlosis’agg; utination were inhibited, it
seemed as positive,other than as negative.
Corynebaterium Pseudotuberlosis ATCC19410 was seeded into sterilized Martin-meat
extract including 0.2% tween-80,cultured vibrately for 3 days, centifugaled and
filtered,made into exotoxin antigen.Selecting appropriate consistency of antigen,antibody
and enzyme-labelled,we did ELISA for examine sera and obtained positive determining
valure,setting blank, positive and negative well.If OD valure of samples were more than
positive determining valure,it was positive,other than it was negative.
We use inhibited agglutination and ELISA examine 100 seras , results in 4 positive
seras , positive percent is 4％.
称 CLA）也称绵羊和山羊假（伪）结核病（pseudotuberculosis in sheep and goat），
是由假（伪）结核棒状杆菌（Corynebacterium pseudotuberculosis）引起的一种
人畜共患的慢性传染病。伪结核棒状杆菌能使绵羊、山羊、骆驼、马、牛等多种动物
致病，发病特征是受害动物的淋巴结肿大，呈脓性干酪性坏死；有的在肺、肝、脾和
子宫角发生大小不等的结节，内含淡黄色干酪样物质。病羊消瘦，生产性能下降，患
病孕羊产出死胎，严重者死亡。由于该病发病缓慢，致死率低，所以常被人们忽视，
发病后用抗生素治疗效果也不佳，所以现在各个国家都对该病的预防、治疗、检测都
重视起来。
分别从杨凌 2 个羊场的 2 只羊的肩前淋巴结脓肿内分离了 2 株菌，经分离鉴定为
假（伪）结核棒状杆菌，记为菌株 A、菌株 B。购买 16 只健康山羊，随机分为 4 组，
菌株 A 复制病例 1 组，菌株 B 复制病例 1 组，标准菌株接种 1 组，空白对照 1 组。从
杨凌养羊场和养羊农户采集了 100 份羊的血清，作为待检血清。用标准菌株制成灭活
苗，免疫 1 只山羊，采集其血液，分离血清，即为阳性血清。将临床健康和菌体凝集
抑制试验阴性羊的剖腹产胎儿的血清作为阴性血清。
将标准菌株（ATCC19410 株）接种灭菌好的含 0.2%吐温-80 的马丁肉汤中，37℃
培养 7d 后制成凝集抑制试验抗原，采集 4 组试验组羊的血清，做菌体凝集抑制试验，
只有空白对照组对该菌原有的凝集不抑制，其他 3 组均能抑制凝集。用待检血清做菌
体凝集抑制试验，同时设置阴性对照和阳性对照，若假（伪）结核棒状杆菌原有的凝
集被抑制，则试验阳性，否则为阴性。
将标准菌株（ATCC19410 株）接种于灭菌好的含 0.2%吐温-80 的马丁肉汤中，振
荡培养 3d，离心，上清液用滤器滤过，制成外毒素抗原，通过 ELISA 酶标抗体和阳
性血清最适浓度的选择、外毒素抗原和阳性血清最适浓度的选择试验，选用适当的抗
原、抗体、酶标抗体浓度，设立空白孔、阳性孔、阴性孔做待检血清的 ELISA 试验，
得出阳性判定值，若待检血清 OD 值大于阴性血清的临界值，则判为阳性，否则判为
阴性。
用建立的菌体凝集抑制试验和 ELISA 方法检测 100 份待检羊血清，得到了相同的
结果,检测到阳性羊 4 只，阳性检出率为 4％。
Caseous lymphadenitis in sheep and goat (CLA) caused by Corynebaterium
Pseudotuberlosis which could infect sheep, goat, camelpa, horse, bovine and so on, is a
kind of zoonotic and chronic infectious. Infected sheep appeared lymphondus
swell,suppurative and caseous necrosis,emerging tubercles in lungs,spleen,uterus horn.
Reduce of production and occur of dead fetus in infecred pregnant sheep.The occur of the
disease was slow and lethal rate low.After infection,effect of antibictic treatment to it was
not good.So every country was increasing attaching importance to prevention theraphy
examina- tion of the disease.
2 bacteria were respectively separated from 2 sheep of Yangling’s 2 sheep-farms in
preshoulder lymphonolus abscess,and identified as Corynebate- rium
Pseudotuberlosis,marked as A and B.16 healthy goats were respectively divided into 4
groups.3 groups were respectively infected bacA bacBand standard Corynebaterium
Pseudotuberlosis,and 4th group as control group.100 sheep sera were collected from
Yangling as samples.Before one month vaccining one goat by sterilized vaccine made by
standard Corynebaterium Pseudotuberlo- s is,we collected serum as negative serum. We
use clinical health goat seras or somatic inhibited agglutination test negative goat cesarean
section fetus seras as negative seras.
Corynebaterium Pseudotuberlosis ATCC19410 was seeded into sterilized Martin-meat
extract including 0.2% tween-80,cultured in 37℃.7 days later, harvested and made into
antigen of agglutination-inhibition test. Sera were collected from 4 groups,except control
group sera,other 3 groups sera all inhibited agglutination of the bacterium.Collecting
examinee’s sera ,we did agglutination-inhibition test meanwhile setting negative and
positive contrast.If Corynebaterium Pseudotuberlosis’agg; utination were inhibited, it
seemed as positive,other than as negative.
Corynebaterium Pseudotuberlosis ATCC19410 was seeded into sterilized Martin-meat
extract including 0.2% tween-80,cultured vibrately for 3 days, centifugaled and
filtered,made into exotoxin antigen.Selecting appropriate consistency of antigen,antibody
and enzyme-labelled,we did ELISA for examine sera and obtained positive determining
valure,setting blank, positive and negative well.If OD valure of samples were more than
positive determining valure,it was positive,other than it was negative.
We use inhibited agglutination and ELISA examine 100 seras , results in 4 positive
seras , positive percent is 4％.
引文
1. A.r.Awan,et a1. A murine model for studying EHV-1 induced abortion.Res. in Cet.Science. 1991,
51:141-148
2. Afzal M, Sakir M, Hussain MM. Corynebacterium pseudotuberculosis infection and lymphadenitis
(taloa or mala) in the camel. Trop Anim Health Prod. 1996 May;28(2):158-62.
3. Aleman M, Spier SJ, Wilson WD, Doherr M. Corynebacterium pseudotuberculosis infection in horses:
538 cases (1982-1993). J Am Vet Med Assoc. 1996 Aug 15;209(4):804-9.
4. Alonso JL, Simon MC, Girones O, Muzquiz JL, Ortega C, Garcia J. The effect of experimental
infection with Corynebacterium pseudotuberculosis on reproduction in adult ewes. Res Vet Sci. 1992
May;52(3):267-72.
5. al-Rawashdeh OF, al-Qudah KM. Effect of shearing on the incidence of caseous lymphadenitis in
Awassi sheep in Jordan. J Vet Med B Infect Dis Vet Public Health. 2000 May;47(4):287-93.
6. Arsenault J, Girard C, Dubreuil P, Daignault D, Galarneau JR, Boisclair J,Simard C, Belanger D.
Prevalence of and carcass condemnation from maedi-visna, paratuberculosis and caseous
lymphadenitis in culled sheep from Quebec, Canada. Prev Vet Med. 2003 May 30;59(1-2):67-81.
7. Ashfaq MK, Campbell SG. Experimentally induced caseous lymphadenitis in goats. Am J Vet Res.
1980 Nov;41(11):1789-92.
8. Barksdale L, Linder R, Sulea IT, Pollice M. Phospholipase D activity of Corynebacterium
pseudotuberculosis (Corynebacterium ovis) and Corynebacterium ulcerans, a distinctive marker within
the genus Corynebacterium.J Clin Microbiol. 1981 Feb;13(2):335-43.
9. Bartolome J, Roca MJ, Marcote E, Moreno R. Corynebacterium pseudotuberculosis adenitis in a
shepherd Med Clin (Barc). 1995 May 13;104(18):699-701.
10. Batcy RG. Aspects of pathogenesis in a mouse model of infection by Corynebacterium
pseudotuberculosis. Aust J Exp Biol Med Sci. 1986 Jun;64 ( Pt 3):237-49.
11. Billington SJ, Esmay PA, Songer JG, Jost BH. Identification and role in virulence of putative iron
acquisition genes from Corynebacterium pseudotuberculosis. FEMS Microbiol Lett. 2002 Feb
19;208(1):41-5.
12. Binns SH, Bailey M, Green LE. Postal survey of ovine caseous lymphadenitis in the United Kingdom
between 1990 and 1999. Vet Rec. 2002 Mar 2;150(9):263-8.
13. Braithwaite CE, Smith EE, Songer JG, Reine AH. Characterization of detergent-soluble proteins of
Corynebacterium pseudotuberculosis. Vet Microbiol. 1993 Dec;38(1-2):59-70.
14. Braverman Y, Chizov-Ginzburg A, Saran A, Winkler M. The role of houseflies (Musca domestica) in
harbouring Corynebacterium pseudotuberculosis in dairy herds in Israel. Rev Sci Tech. 1999
Dec;18(3):681-90.
36 羊干酪样淋巴结炎诊断方法的研究
15. Bregenzer T, Frei R, Ohnacker H, Zimmerli W. Corynebacterium pseudotuberculosis infection in a
butcher. Clin Microbiol Infect. 1997 Feb;3(6):696-698.
16. Brogden KA, Chedid L, Cutlip RC, Lehmkuhl HD, Sacks J. Effect of muramyl dipeptide on
immunogenicity of Corynebacterium pseudotuberculosis whole-cell vaccines in mice and lambs. Am J
Vet Res. 1990 Feb;51(2):200-2.
17. Brogden KA, Cutlip RC, Lehmkuhl HD. Experimental Corynebacterium pseudotuberculosis infection
in lambs. Am J Vet Res. 1984 Aug;45(8):1532-4.
18. Brogden KA, Engen RL, Songer JG, Gallagher J. Changes in ovine erythrocyte morphology due to
sphingomyelin degradation by Corynebacterium pseudotuberculosis phospholipase D. Microb Pathog.
1990 Feb;8(2):157-62.
19. Brogden KA, Engen RL. Alterations in the phospholipid composition and morphology of ovine
erythrocytes after intravenous inoculation of Corynebacterium pseudotuberculosis. Am J Vet Res.
1990 Jun;51(6):874-7.
20. Brown CC, Olander HJ, Biberstein EL, Moreno D. Serologic response and lesions in goats
experimentally infected with Corynebacterium pseudotuberculosis of caprine and equine origins. Am J
Vet Res. 1985 Nov;46(11):2322-6.
21. Brown CC, Olander HJ, Biberstein EL, Morse SM. Use of a toxoid vaccine to protect goats against
intradermal challenge exposure to Corynebacterium pseudotuberculosis. Am J Vet Res. 1986
May;47(5):1116-9.
22. Brown CC, Olander HJ, Zometa C, Alves SF. Serodiagnosis of inapparent caseous lymphadenitis in
goats and sheep, using the synergistic hemolysis-inhibition test. Am J Vet Res. 1986 Jul;47(7):1461-3.
23. Brumbaugh GW, Ekman TL. Corynebacterium pseudotuberculosis bacteremia in two horses. J Am Vet
Med Assoc. 1981 Feb 1;178(3):300-1.
24. Cameron CM, Bester FJ. An improved Corynebacterium pseudotuberculosis vaccine for sheep.
Onderstepoort J Vet Res. 1984 Dec;51(4):263-7.
25. Cetinkaya B, Karahan M, Atil E, Kalin R, De Baere T, Vaneechoutte M. Identification of
Corynebacterium pseudotuberculosis isolates from sheep and goats by PCR. Vet Microbiol. 2002 Aug
2;88(1):75-83.
26. Chaplin PJ, De Rose R, Boyle JS, McWaters P, Kelly J, Tennent JM, Lew AM, Scheerlinck JP.
Targeting improves the efficacy of a DNA vaccine against Corynebacterium pseudotuberculosis in
sheep. Infect Immun. 1999 Dec;67(12):6434-8.
27. Connor KM, Quirie MM, Baird G, Donachie W. Characterization of United Kingdom isolates of
Corynebacterium pseudotuberculosis using pulsed-field gel electrophoresis. J Clin Microbiol. 2000
Jul;38(7):2633-7.
28. Costa LR, Spier SJ, Hirsh DC. Comparative molecular characterization of Corynebacterium
参考文献 37
pseudotuberculosis of different origin. Vet Microbiol. 1998 May;62(2):135-43.
29. Cuevas WA, Songer JG. Arcanobacterium haemolyticum phospholipase D is genetically and
functionally similar to Corynebacterium pseudotuberculosis phospholipase D. Infect Immun. 1993
Oct;61(10):4310-6.
30. De Rose R, Tennent J, McWaters P, Chaplin PJ, Wood PR, Kimpton W, Cahill R,Scheerlinck JP.
Efficacy of DNA vaccination by different routes of immunisation in sheep. Vet Immunol
Immunopathol. 2002 Nov;90(1-2):55-63.
31. Dercksen DP, Brinkhof JM, Dekker-Nooren T, Maanen K, Bode CF, Baird G, Kamp EM. A comparison
of four serological tests for the diagnosis of caseous lymphadenitis in sheep and goats. Vet Microbiol.
2000 Jul 31;75(2):167-75.
32. Dercksen DP, ter Laak EA, Schreuder BE. Eradication programme for caseous lymphadenitis in goats
in The Netherlands. Vet Rec. 1996 Mar 9;138(10):237.
33. Dmitriev AV, Smola J, Shalen K, Golubkov VI, Totolian AA. The cloning and expression of the
phospholipase D gene from Corynebacterium pseudotuberculosis Zh Mikrobiol Epidemiol Immunobiol.
1994 Jul-Aug;(4):24-8.
34. Doherr MG, Carpenter TE, Hanson KM, Wilson WD, Gardner IA. Risk factors associated with
Corynebacterium pseudotuberculosis infection in California horses. Prev Vet Med. 1998 Jun
30;35(4):229-39.
35. Doherr MG, Carpenter TE, Wilson WD, Gardner IA. Application and evaluation of a mailed
questionnaire for an epidemiologic study of Corynebacterium pseudotuberculosis infection in horses.
Prev Vet Med. 1998 Jun 30;35(4):241-53.
36. Doherr MG, Carpenter TE, Wilson WD, Gardner IA. Effect of different sampling techniques on odds
ratio estimates using hospital-based cases and controls. Prev Vet Med. 1997 Sep;32(1-2):77-93.
37. Doherr MG, Carpenter TE, Wilson WD, Gardner IA. Evaluation of temporal and spatial clustering of
horses with Corynebacterium pseudotuberculosis infection. Am J Vet Res. 1999 Mar;60(3):284-91.
38. Egen NB, Cuevas WA, McNamara PJ, Sammons DW, Humphreys R, Songer JG. Purification of the
phospholipase D of Corynebacterium pseudotuberculosis by recycling isoelectric focusing. Am J Vet
Res. 1989 Aug;50(8):1319-22.
39. Eggleton DG, Haynes JA, Middleton HD, Cox JC. Immunisation against ovine caseous lymphadenitis:
correlation between Corynebacterium pseudotuberculosis toxoid content and protective efficacy in
combined clostridial-corynebacterial vaccines. Aust Vet J. 1991 Oct;68(10):322-5.
40. Eggleton DG, Middleton HD, Doidge CV, Minty DW. Immunisation against ovine caseous
lymphadenitis: comparison of Corynebacterium pseudotuberculosis vaccines with and without bacterial
cells. Aust Vet J. 1991 Oct;68(10):317-9.
41. Ellis JA, Campos M, Snyder M, Chelak B, Haines DM. Local production of tumor necrosis
38 羊干酪样淋巴结炎诊断方法的研究
factor-alpha in corynebacterial pulmonary lesions in sheep. Vet Pathol. 1995 Jan;32(1):68-71.
42. Ellis JA, Hawk DA, Holler LD, Mills KW, Pratt DL. Differential antibody responses to
Corynebacterium pseudotuberculosis in sheep with naturally acquired caseous lymphadenitis. J Am Vet
Med Assoc. 1990 May 15;196(10):1609-13.
43. Ellis JA, Hawk DA, Mills KW, Pratt DL. Antigen specificity and activity of ovine antibodies induced
by immunization with Corynebacterium pseudotuberculosis culture filtrate. Vet Immunol
Immunopathol. 1991 Jul;28(3-4):303-16.
44. Ellis JA, Hawk DA, Mills KW, Pratt DL. Antigen specificity of antibody responses to Corynebacterium
pseudotuberculosis in naturally infected sheep with caseous lymphadenitis. Vet Immunol
Immunopathol. 1991 Jul;28(3-4):289-301.
45. Ellis JA, Russell HI, Du CW. Effect of selected cytokines on the replication of Corynebacterium
pseudotuberculosis and ovine lentiviruses in pulmonary macrophages. Vet Immunol Immunopathol.
1994 Jan;40(1):31-47.
46. Ellis TM, Sutherland SS, Wilkinson FC, Mercy AR, Paton MW. The role of Corynebacterium
pseudotuberculosis lung lesions in the transmission of this bacterium to other sheep. Aust Vet J. 1987
Sep;64(9):261-3.
47. Garg DN, Chandiramani NK. Cellular and humoral immune responses in sheep experimentally injected
with killed and live Corynebacterium pseudotuberculosis. Zentralbl Bakteriol Mikrobiol Hyg [A]. 1985
Aug;260(1):117-25.
48. Glass EN, De Lahunta A, Jackson C. Brain abscess in a goat. Cornell Vet. 1993 Oct;83(4):275-82.
49. H.Meyer，et al:1992,Rapid identification and differentiation of the vaccinestrain Rae H from EHV-1
field isolates using a non- radioactive DNA probe ,Vet. Microl., 30:13 一 20.
50. Hatfield, R.M. ,B. A. Morris. And R. R. Henry. Development of an Enzyme-linked Immunosorbent
Assay for the detection of humoral antibody to pasteurella anatipestifer[J]. Avian pathology, 1987，
16:123 一 140
51. Haynes JA, Tkalcevic J, Nisbet IT. Production of an enzymatically inactive analog of phospholipase D
from Corynebacterium pseudotuberculosis. Gene. 1992 Sep 21;119(1):119-21.
52. Hebert GA, Hancock GA. Synergistic hemolysis exhibited by species of staphylococci. J Clin
Microbiol. 1985 Sep;22(3):409-15.
53. Hermoso De Mendoza J, Nieto CG, Arenas A, Alonso JM, Rey J, Gil MC, Anton J, Cardenal A,
Hermoso De Mendoza M. An indirect fluorescent antibody technique for detection of
anti-Dermatophilus congolensis antibodies in sheep. Trop Anim Health Prod. 1994 May;26(2):74-8.
54. Herrera-Alcaraz E, Valero-Guillen P, Martin-Luengo F, Canteras-Jordana M. Numerical analysis of
fatty and mycolic acid profiles of Corynebacterium urealyticum and other related corynebacteria.
Microbiologia. 1993 Apr;9(1):53-62.
参考文献 39
55. Hodgson AL, Bird P, Nisbet IT. Cloning, nucleotide sequence, and expression in Escherichia coli of the
phospholipase D gene from Corynebacterium pseudotuberculosis. J Bacteriol. 1990
Mar;172(3):1256-61.
56. Hodgson AL, Carter K, Tachedjian M, Krywult J, Corner LA, McColl M, Cameron A. Efficacy of an
ovine caseous lymphadenitis vaccine formulated using a genetically inactive form of the
Corynebacterium pseudotuberculosis phospholipase D. Vaccine. 1999 Feb 26;17(7-8):802-8.
57. Hodgson AL, Krywult J, Corner LA, Rothel JS, Radford AJ. Rational attenuation of Corynebacterium
pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle. Infect Immun. 1992
Jul;60(7):2900-5.
58. Hodgson AL, Tachedjian M, Corner LA, Radford AJ. Protection of sheep against caseous
lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis.
Infect Immun. 1994 Dec;62(12):5275-80.
59. Holstad G, Teige J Jr, Larsen HJ. Corynebacterium pseudotuberculosis infection in goats. VIII. The
effect of vaccination against experimental infection. Acta Vet Scand. 1989;30(3):275-83.
60. Holstad G, Teige J Jr. Corynebacterium pseudotuberculosis infection in goats. VII. Clinical,
pathological, serological and hematological changes after subcutaneous inoculation of the organism.
Acta Vet Scand. 1988;29(3-4):287-94.
61. Holstad G. Corynebacterium pseudotuberculosis infection in goats. IX. The effect of vaccination
against natural infection. Acta Vet Scand. 1989;30(3):285-93.
62. Holstad G. Corynebacterium pseudotuberculosis infection in goats. V. Relationship between the
infection and lesions resulting from vaccination against paratuberculosis. Acta Vet Scand.
1986;27(4):617-22.
63. Holstad G. Corynebacterium pseudotuberculosis infection in goats. IV. Course of the infection in two
recently infected goat herds. Acta Vet Scand. 1986;27(4):609-16.
64. Holstad G. Corynebacterium pseudotuberculosis infection in goats. III. The influence of age. Acta Vet
Scand. 1986;27(4):598-608.
65. Holstad G. Corynebacterium pseudotuberculosis infection in goats. II. The prevalence of caseous
lymphadenitis in 36 goat herds in Northern Norway. Acta Vet Scand. 1986;27(4):584-97.
66. Hommez J, Devriese LA, Vaneechoutte M, Riegel P, Butaye P, Haesebrouck F. Identification of
nonlipophilic corynebacteria isolated from dairy cows with mastitis. J Clin Microbiol. 1999
Apr;37(4):954-7.
67. Hsu TY, Renshaw HW, Livingston CW Jr, Augustine JL, Zink DL, Gauer BB. Corynebacterium
pseudotuberculosis exotoxin: fatal hemolytic anemia induced in gnotobiotic neonatal small ruminants
by parenteral administration of preparations containing exotoxin. Am J Vet Res. 1985
May;46(5):1206-11.
40 羊干酪样淋巴结炎诊断方法的研究
68. Hudson，G.C., et al:1988, lndentification and location of a gene in equine herpesvirus 一 1analogous to
the major glyeoprotein gB of herpes simplex vius .proceedings .V. lntermational Conference Equine
Infectious，Kentucky，USA, 111 一 117.
69. Ioneda T. Chromatographic and mass spectrometric characterization of 3-O-benzoyl methyl ester
derivatives of mycolic acid fractions from Corynebacterium pseudotuberculosis, C. diphtheriae and
Rhodococcus rhodochrous. Chem Phys Lipids. 1993 Jun;65(2):93-101.
70. Ioneda T. Mass spectrometric analysis of O-peracetylated derivatives of1-monomycoloylglycerol
isolated from Corynebacterium pseudotuberculosis, Rhodococcus rhodochrous and R. lentifragmentus.
Chem Phys Lipids. 1990 Jun;54(3-4):215-20.
71. Judson R, Songer JG. Corynebacterium pseudotuberculosis: in vitro susceptibility to 39 antimicrobial
agents. Vet Microbiol. 1991 Apr;27(2):145-50.
72. Kaba J, Kutschke L, Gerlach GF. Development of an ELISA for the diagnosis of Corynebacterium
pseudotuberculosis infections in goats. Vet Microbiol. 2001 Jan 26;78(2):155-63.
73. Keslin MH, McCoy EL, McCusker JJ, Lutch JS. Corynebacterium pseudotuberculosis. A new cause of
infectious and eosinophilic pneumonia. Am J Med. 1979 Aug;67(2):228-31.
74. Kuria JK, Holstad G. A seroepidemiological investigation of Corynebacterium pseudotuberculosis
infection in sheep flocks in southern Norway. Acta Vet Scand. 1989;30(1):107-8.
75. Kuria JK, Holstad G. Serological investigation of Corynebacterium pseudotuberculosis infection in
sheep--correlation between the hemolysis inhibition test and the ELISA test. Acta Vet Scand.
1989;30(1):109-10.
76. Kuria JK, Mbuthia PG, Kang'ethe EK, Wahome RG. Caseous lymphadenitis in goats: the pathogenesis,
incubation period and serological response after experimental infection. Vet Res Commun. 2001
Feb;25(2):89-97.
77. Kutschke L, Ganter M, Kaba J. Efficacy of a flock-specific pseudotuberculosis vaccine in goats. Dtsch
Tierarztl Wochenschr. 2000 Dec;107(12):495-500.
78. Lan DT, Makino S, Shirahata T, Yamada M, Nakane A. Tumor necrosis factor alpha and gamma
interferon are required for the development of protective immunity to secondary Corynebacterium
pseudotuberculosis infection in mice. J Vet Med Sci. 1999 Nov;61(11):1203-8.
79. Lan DT, Makino S, Shirahata T, Yamada M, Nakane. Complement receptor type 3 plays an important
role in development of protective immunity to primary and secondary Corynebacterium
pseudotuberculosis infection in mice. Microbiol Immunol. 1999;43(12):1103-6.
80. Lan DT, Taniguchi S, Makino S, Shirahata T, Nakane A. Role of endogenous tumor necrosis factor
alpha and gamma interferon in resistance to Corynebacterium pseudotuberculosis infection in mice.
Microbiol Immunol. 1998;42(12):863-70.
81. LeaMaster BR, Shen DT, Gorham JR, Leathers CW, Wells HD. Efficacy of Corynebacterium
参考文献 41
pseudotuberculosis bacterin for the immunologic protection of sheep against development of caseous
lymphadenitis. Am J Vet Res. 1987 May;48(5):869-72.
82. Lester WA, Schousboe M, Chambers S, Patton WN. A second case of Corynebacterium
pseudotuberculosis in New Zealand. N Z Med J. 1997 Dec 12;110(1057):469-70.
83. Lund A, Almlid T, Larsen HJ, Steine T. Antibodies to Corynebacterium pseudotuberculosis in adult
goats from a naturally infected herd. Acta Vet Scand. 1982;23(4):473-82.
84. Maki LR, Shen SH, Bergstrom RC, Stetzenbach LD. Diagnosis of Corynebacterium
pseudotuberculosis infections in sheep, using an enzyme-linked immunosorbent assay. Am J Vet Res.
1985 Jan;46(1):212-4.
85. McNamara PJ, Bradley GA, Songer JG. Targeted mutagenesis of the phospholipase D gene results in
decreased virulence of Corynebacterium pseudotuberculosis. Mol Microbiol. 1994 Jun;12(6):921-30.
86. McNamara PJ, Cuevas WA, Songer JG. Toxic phospholipases D of Corynebacterium
pseudotuberculosis, C. ulcerans and Arcanobacterium haemolyticum: cloning and sequence homology.
Gene. 1995 Apr 14;156(1):113-8.
87. Menzies PI, Muckle CA, Brogden KA, Robinson L. A field trial to evaluate a whole cell vaccine for
the prevention of caseous lymphadenitis in sheep and goat flocks. Can J Vet Res. 1991
Oct;55(4):362-6.
88. Menzies PI, Muckle CA. The use of a microagglutination assay for the detection of antibodies to
Corynebacterium pseudotuberculosis in naturally infected sheep and goat flocks. Can J Vet Res. 1989
Jul;53(3):313-8.
89. Mills AE, Mitchell RD, Lim EK. Corynebacterium pseudotuberculosis is a cause of human necrotising
granulomatous lymphadenitis. Pathology. 1997 May;29(2):231-3.
90. Moller K, Agerholm JS, Ahrens P, Jensen NE, Nielsen TK. Abscess disease, caseous lymphadenitis,
and pulmonary adenomatosis in imported sheep. J Vet Med B Infect Dis Vet Public Health. 2000
Feb;47(1):55-62.
91. Moore RJ, Rothel L, Krywult J, Radford AJ, Lund K, Hodgson AL. Foreign gene expression in
Corynebacterium pseudotuberculosis: development of a live vaccine vector. Vaccine. 1999 Oct
14;18(5-6):487-97.
92. Moore RJ, Stewart DJ, Lund K, Hodgson AL. Vaccination against ovine footrot using a live bacterial
vector to deliver basic protease antigen. FEMS Microbiol Lett. 2001 Jan 15;194(2):193-6.
93. Muckle CA, Gyles CL. Characterization of strains of corynebacterium pseudotuberculosis. Can J
Comp Med. 1982 Apr;46(2):206-8.
94. Muckle CA, Gyles CL. Relation of lipid content and exotoxin production to virulence of
Corynebacterium pseudotuberculosis in mice. Am J Vet Res. 1983 Jun;44(6):1149-53.
95. Muckle CA, Menzies PI, Li Y, Hwang YT, van Wesenbeeck M. Analysis of the immunodominant
42 羊干酪样淋巴结炎诊断方法的研究
antigens of Corynebacterium pseudotuberculosis. Vet Microbiol. 1992 Jan;30(1):47-58.
96. Ndikuwera J, Odiawo GO, Usenik EA, Kock ND, Ogaa JS, Kuiper. Chronic contagious ecthyma and
caseous lymphadenitis in two Boer goats. Vet Rec. 1992 Dec 19-26;131(25-26):584-5.
97. Nord K, Holstad G, Eik LO, Gronstol H. Control of caprine arthritis-encephalitis virus and
Corynebacterium pseudotuberculosis infection in a Norwegian goat herd. Acta Vet Scand.
1998;39(1):109-17.
98. Olson ME, Ceri H, Morck DW, Buret AG, Read RR. Biofilm bacteria: formation and comparative
susceptibility to antibiotics. Can J Vet Res. 2002 Apr;66(2):86-92.
99. Onovian, O. et. al. Detection of antibody against M. mycoides subspmycoides in cattle by an
enzyme-linked immunosorbent assay[J]. Veterinary Record, 1979,105:165 一 167.
100. Paton MW, Buller NB, Rose IR, Ellis TM. Effect of the interval between shearing and dipping on the
spread of Corynebacterium pseudotuberculosis infection in sheep. Aust Vet J. 2002 Aug;80(8):494-6.
101. Paton MW, Mercy AR, Sutherland SS, Ellis TM, Duda SR. The effect of antibody to caseous
lymphadenitis in ewes on the efficacy of Aust Vet J. 1991 Apr;68(4):143-6.
102. Paton MW, Mercy AR, Wilkinson FC, Gardner JJ, Sutherland SS, Ellis TM. The effects of caseous
lymphadenitis on wool production and bodyweight in young Aust Vet J. 1988 Apr;65(4):117-9.
103. Paton MW, Rose IR, Hart RA, Sutherland SS, Mercy AR, Ellis TM, Dhaliwal JA. New infection with
Corynebacterium pseudotuberculosis reduces wool production. Aust Vet J. 1994 Feb;71(2):47-9.
104. Paton MW, Sutherland SS, Rose IR, Hart RA, Mercy AR, Ellis TM. The spread of Corynebacterium
pseudotuberculosis infection to unvaccinated and vaccinated sheep. Aust Vet J. 1995 Jul;72(7):266-9.
105. Peel MM, Palmer GG, Stacpoole AM, Kerr TG. Human lymphadenitis due to Corynebacterium
pseudotuberculosis: report of ten cases from Australia and review. Clin Infect Dis. 1997
Feb;24(2):185-91.
106. Pepin M, Bernard S, Menanteau P, Olivier M, Berthon P, Lantier F. Reactivity of workshop
monoclonal antibodies with normal and pathological ovine lymph nodes. Vet Immunol Immunopathol.
1993 Nov;39(1-3):249-67.
107. Pepin M, Boisrame A, Marly J. Corynebacterium pseudotuberculosis: biochemical properties,
production of toxin and virulence of ovine and caprine strains. Ann Rech Vet. 1989;20(1):111-5.
108. Pepin M, Fontaine JJ, Pardon P, Marly J, Parodi AL. Histopathology of the early phase during
experimental Corynebacterium pseudotuberculosis infection in lambs. Vet Microbiol. 1991
Oct;29(2):123-34.
109. Pepin M, Pardon P, Lantier F, Marly J, Levieux D, Lamand M. Experimental Corynebacterium
pseudotuberculosis infection in lambs: kinetics of bacterial dissemination and inflammation. Vet
Microbiol. 1991 Feb 15;26(4):381-92.
110. Pepin M, Pardon P, Marly J, Lantier F, Arrigo JL. Acquired immunity after primary caseous
参考文献 43
lymphadenitis in sheep. Am J Vet Res. 1993 Jun;54(6):873-7.
111. Pepin M, Pardon P, Marly J, Lantier F. Corynebacterium pseudotuberculosis infection in adult ewes by
inoculation in the external ear. Am J Vet Res. 1988 Apr;49(4):459-63.
112. Pepin M, Pittet JC, Olivier M, Gohin I. Cellular composition of Corynebacterium pseudotuberculosis
pyogranulomas in sheep. J Leukoc Biol. 1994 Nov;56(5):666-70.
113. Pepin M, Seow HF, Corner L, Rothel JS, Hodgson AL, Wood PR. Cytokine gene expression in sheep
following experimental infection with various strains of Corynebacterium pseudotuberculosis differing
in virulence. Vet Res. 1997;28(2):149-63.
114. Piontkowski MD, Shivvers DW. Evaluation of a commercially available vaccine against
Corynebacterium pseudotuberculosis for use in sheep. J Am Vet Med Assoc. 1998 Jun
1;212(11):1765-8.
115. Pittet JC, Pepin M, Normier G, Binz H, Le Pape A. Lymphoscintigraphy via the targeting of
macrophages with 99mTc-J001X poly-galactoside in a model of pyogranulomas developed in sheep
lymph nodes. Nucl Med Biol. 1995 Apr;22(3):355-65.
116. Pogson CA, Simmons CP, Strugnell RA, Hodgson AL. Cloning and manipulation of the
Corynebacterium pseudotuberculosis recA gene for live vaccine vector development. FEMS
Microbiol Lett. 1996 Sep 1;142(2-3):139-45.
117. Poonacha KB, Donahue JM. Abortion in a mare associated with Corynebacterium pseudotuberculosis
infection. J Vet Diagn Invest. 1995 Oct;7(4):563-4.
118. Prescott JF, Menzies PI, Hwang YT. An interferon-gamma assay for diagnosis of Corynebacterium
pseudotuberculosis infection in adult sheep from a research flock. Vet Microbiol. 2002 Sep
2;88(3):287-97.
119. Prodhan MA, Olander HJ, Gardner IA. A comparison of dot-blot assay with the synergistic haemolytic
inhibition test in goats naturally infected with Corynebacterium pseudotuberculosis. Vet Res Commun.
1993;17(3):193-6.
120. Pusterla N, Watson JL, Affolter VK, Magdesian KG, Wilson WD, Carlson GP. Purpura haemorrhagica
in 53 horses. Vet Rec. 2003 Jul 26;153(4):118-21.
121. Radwan AI, el-Magawry S, Hawari A, al-Bekairi SI, Rebleza RM. Corynebacterium
pseudotuberculosis infection in camels (Camelus dromedarius) in Saudi Arabia. Trop Anim Health
Prod. 1989 Nov;21(4):229-30.
122. Renshaw HW, Graff VP, Gates NL. Visceral caseous lymphadenitis in thin ewe syndrome: isolation of
Corynebacterium, Staphylococcus, and Moraxella spp from internal abscesses in emaciated ewes. Am J
Vet Res. 1979 Aug;40(8):1110-1126
123. Richards M, Hurse A. Corynebacterium pseudotuberculosis abscesses in a young butcher. Aust N Z J
Med. 1985 Feb;15(1):85-6.
44 羊干酪样淋巴结炎诊断方法的研究
124. Rothel JS, Hurst L, Seow HF, Pepin M, Berthon P, Corner LA, Wood PR. Analysis of ovine IL-1 beta
production in vivo and in vitro by enzyme immunoassay and immunohistochemistry. Vet Immunol
Immunopathol. 1997 Jul;57(3-4):267-78.
125. Schreuder BE, Ter Laak EA, De Gee AL. Corynebacterium pseudotuberculosis in milk of CL affected
goats. Vet Rec. 1990 Oct 13;127(15):387.
126. Schreuder BE, ter Laak EA, Dercksen DP. Eradication of caseous lymphadenitis in sheep with the help
of a newly developed ELISA technique. Vet Rec. 1994 Aug 20;135(8):174-6.
127. Scott PR, Collie DD, Hume LH. Caseous lymphadenitis in a commercial ram stud in Scotland. Vet
Rec. 1997 Nov 22;141(21):548-9.
128. Serikawa S, Ito S, Hatta T, Kusakari N, Senna K, Hiramune T, Kikuchi N, Yanagawa R. Protection
from caseous lymphadenitis in sheep by spraying iodine tincture on shearing wounds. J Vet Med Sci.
1994 Apr;56(2):411-2.
129. Serikawa S, Ito S, Hatta T, Kusakari N, Senna K, Sawara S, Hiramune T, Kikuchi N, Yanagawa R.
Seroepidemiological evidence that shearing wounds are mainly responsible for Corynebacterium
pseudotuberculosis infection in sheep. J Vet Med Sci. 1993 Aug;55(4):691-2.
130. Shpigel NY, Elad D, Yeruham I, Winkler M, Saran A. An outbreak of Corynebacterium
pseudotuberculosis infection in an Israeli dairy herd. Vet Rec. 1993 Jul 24;133(4):89-94.
131. Shulaw WP, Bech-Nielsen S, Rings DM, Getzy DM, Woodruff TS. Serodiagnosis of paratuberculosis
in sheep by use of agar gel immunodiffusion. Am J Vet Res. 1993 Jan;54(1):13-9.
132. Simmons CP, Dunstan SJ, Tachedjian M, Krywult J, Hodgson AL, Strugnell RA. Vaccine potential of
attenuated mutants of Corynebacterium pseudotuberculosis in sheep. Infect Immun. 1998
Feb;66(2):474-9.
133. Simmons CP, Hodgson AL, Strugnell RA. Attenuation and vaccine potential of aroQ mutants of
Corynebacterium pseudotuberculosis. Infect Immun. 1997 Aug;65(8):3048-56.
134. Skalka B, Literak I, Chalupa P, Votava M. Phospholipase D-neutralization in serodiagnosis of
Arcanobacterium haemolyticum and Corynebacterium pseudotuberculosis infections. Zentralbl
Bakteriol. 1998 Dec;288(4):463-70.
135. Skalka B, Literak I, Michalik I, Skrivanek M. Corynebacterium pseudotuberculosis infection in goats
in the Czech Republic. Zentralbl Veterinarmed B. 1998 Feb;45(1):31-5.
136. Skalka B, Literak I. Serodiagnosis of caseous lymphadenitis (pseudotuberculosis) in sheep Vet Med
(Praha). 1994;39(9):533-9.
137. Songer JG, Beckenbach K, Marshall MM, Olson GB, Kelley L. Biochemical and genetic
characterization of Corynebacterium pseudotuberculosis. Am J Vet Res. 1988 Feb;49(2):223-6.
138. Songer JG, Hilwig RW, Leeming MN, Iandolo JJ, Libby SJ. Transformation of Corynebacterium
pseudotuberculosis by electroporation. Am J Vet Res. 1991 Aug;52(8):1258-61.
参考文献 45
139. Songer JG, Libby SJ, Iandolo JJ, Cuevas WA. Cloning and expression of the phospholipase D gene
from Corynebacterium pseudotuberculosis in Escherichia coli. Infect Immun. 1990 Jan;58(1):131-6.
140. Stanford K, Brogden KA, McClelland LA, Kozub GC, Audibert F. The incidence of caseous
lymphadenitis in Alberta sheep and assessment of impact by vaccination with commercial and
experimental vaccines. Can J Vet Res. 1998 Jan;62(1):38-43.
141. Sting R, Steng G, Spengler D. Serological studies on Corynebacterium pseudotuberculosis infections
in goats using enzyme-linked immunosorbent assay. Zentralbl Veterinarmed B. 1998
May;45(4):209-16.
142. Sutherland SS, Ellis TM, Paton MJ, Mercy AR. Serological response of vaccinated sheep after
challenge with Corynebacterium pseudotuberculosis. Aust Vet J. 1992 Jul;69(7):168-9.
143. Sutherland SS, Hart RA, Buller NB. Genetic differences between nitrate-negative and nitrate-positive
C. pseudotuberculosis strains using restriction fragment length polymorphisms. Vet Microbiol. 1996
Mar;49(1-2):1-9.
144. Sutherland SS, Hart RA, Buller NB. Ribotype analysis of Corynebacterium pseudotuberculosis
isolates from sheep and goats. Aust Vet J. 1993 Dec;70(12):454-6.
145. Sutherland SS, Speijers EJ, Andres B. Comparison of the exotoxins of four strains of Corynebacterium
pseudotuberculosis. Res Vet Sci. 1989 Sep;47(2):190-4.
146. Synder, D. B. Rapid serological profiling by Enzyme-linked Immunosorbent Assay: measurement of
antibody activity titer against Newcastle Disease Virus in a single serum dilution[J]. Avian Diseases,
1983,270):161 一 170
147. Tachedjian M, Krywult J, Moore RJ, Hodgson AL. Caseous lymphadenitis vaccine development:
site-specif ic inactivation of the Corynebacterium pseudotuberculosis phospholipase D gene. Vaccine.
1995 Dec;13(18):1785-92.
148. Takahashi T, Mori Y, Kobayashi H, Ochi M, Kikuchi N, Hiramune T. Phylogenetic positions and
assignment of swine and ovine corynebacterial isolates based on the 16S rDNA sequence. Microbiol
Immunol. 1997;41(9):649-55.
149. Tambourgi DV, De Sousa Da Silva M, Billington SJ, Goncalves De Andrade RM,Magnoli FC, Songer
JG, Van Den Berg CW. Mechanism of induction of complement susceptibility of erythrocytes by spider
and bacterial sphingomyelinases. Immunology. 2002 Sep;107(1):93-101.
150. ter Laak EA, Bosch J, Bijl GC, Schreuder BE. Double-antibody sandwich enzyme-linked
immunosorbent assay and immunoblot analysis used for control of caseous lymphadenitis in goats and
sheep. Am J Vet Res. 1992 Jul;53(7):1125-32.
151. Unanian MM, Feliciano Silva AE, Pant KP. Abscesses and caseous lymphadenitis in goats in tropical
semi-arid north-east Brazil.Trop Anim Health Prod. 1985 Feb;17(1):57-62.
152. Vaneechoutte M, Riegel P, de Briel D, Monteil H, Verschraegen G, De Rouck A,Claeys G. Evaluation
46 羊干酪样淋巴结炎诊断方法的研究
of the applicability of amplified rDNA-restriction analysis (ARDRA) to identification of species of the
genus Corynebacterium. Res Microbiol. 1995 Oct;146(8):633-41.
153. Walker J, Jackson H, Brandon MR, Meeusen E. Lymphocyte subpopulations in pyogranulomas of
caseous lymphadenitis. Clin Exp Immunol. 1991 Oct;86(1):13-8.
154. Walker J, Jackson HJ, Eggleton DG, Meeusen EN, Wilson MJ, Brandon MR. Identification of a novel
antigen from Corynebacterium pseudotuberculosis that protects sheep against caseous lymphadenitis.
Infect Immun. 1994 Jun;62(6):2562-7.
155. Watson PJ, Preece BE. Report on 31 caseous lymphadenitis infected sheep farms in England and
Wales. Vet Rec. 2001 May 26;148(21):663-5.
156. Williamson LH. Caseous lymphadenitis in small ruminants. Vet Clin North Am Food Anim Pract.
2001 Jul;17(2):359-71, vii.
157. Wilson MJ, Brandon MR, Walker J. Molecular and biochemical characterization of a protective
40-kilodalton antigen from Corynebacterium pseudotuberculosis. Infect Immun. 1995
Jan;63(1):206-11.
158. Yeruham I, Braverman Y, Shpigel NY, Chizov-Ginzburg A, Saran A, Winkler M. Mastitis in dairy
cattle caused by Corynebacterium pseudotuberculosis and the feasibility of transmission by houseflies.
I. Vet Q. 1996 Sep;18(3):87-9.
159. Yeruham I, Elad D, Friedman S, Perl S. Corynebacterium pseudotuberculosis infection in Israeli dairy
cattle. Epidemiol Infect. 2003 Oct;131(2):9,147-55.
160. Yeruham I, Elad D, Perl S, Ram A. Necrotic-ulcerative dermatitis on the heels of heifers in a dairy
herd infected with Corynebacterium pseudotuberculosis. Vet Rec. 2003 May 10;152(19):598-600.
161. Yeruham I, Elad D, Van-Ham M, Shpigel NY, Perl S. Corynebacterium pseudotuberculosis infection in
Israeli cattle: clinical and epidemiological studies. Vet Rec. 1997 Apr 19;140(16):423-7.
162. Yozwiak ML, Songer JG. Effect of Corynebacterium pseudotuberculosis phospholipase D on viability
and chemotactic responses of ovine neutrophils. Am J Vet Res. 1993 Mar;54(3):392-7.
163. Zhang Y, Praszkier J, Hodgson A, Pittard AJ. Molecular analysis and characterization of a
broad-host-range plasmid, pEP2. J Bacteriol. 1994 Sep;176(18):5718-28.
164. Zhao HK, Hiramune T, Kikuchi N, Yanagawa R, Ito S, Hatta T, Serikawa S, Oe Y. Selective medium
containing fosfomycin, nalidixic acid, and culture supernatant of Rhodococcus equi for isolation of
Corynebacterium pseudotuberculosis. Zentralbl Veterinarmed B. 1991 Dec;38(10):743-8.
165. Zhao HK, Morimura H, Hiramune T, Kikuchi N, Yanagawa R, Serikawa S. Antimicrobial
susceptibility of Corynebacterium pseudotuberculosis isolated from lesions of caseous lymphadenitis
in sheep in Hokkaido, Japan. J Vet Med Sci. 1991 Apr;53(2):355-6.
166. Zhao HK, Yonekawa K, Takahashi T, Kikuchi N, Hiramune T, Yanagawa R. Isolation of
Corynebacterium pseudotuberculosis from the cervical canal of clinically normal sows. Res Vet Sci.
参考文献47
1993 Nov;55(3):356-9.
167. 郭在军等.骆驼伪结核棒状杆菌的诊断.中国畜禽传染病.1988,(2):33
168. 侯从远.山羊伪结核诊断报告.中国畜牧兽医,1962,(7):20-22.
169. 黄引贤,李乃津等.羊伪结核棒状杆菌某些特性的初步研究,1988,(2):3-4
170. 蒋成淦主编.酶免疫测定法.北京：人民卫生出版社.1984
171. 李福刚,袁玉国,聂春应等.奶山羊假结核棒状杆菌病的诊治.江西畜牧兽医杂.2002,(5):23-24
172. 李新泉等.莎能奶山羊假结核病净化报告.中国兽医杂志,1994,20,22-23
173. 史学增,尹慧春.鹿伪结核棒状杆菌病的研究近况.吉林畜牧兽医,1995,17(1):13-15
174. 汪家政,范明主编.蛋白质技术手册.北京：科学出版社.2001,65-67
175. 赵宏坤,敖力布.羊伪结核病免疫方法的研究.中国畜禽传染病,1996(5):29-32
176. 赵宏坤,吉增福.由溶解的山羊胎儿分离出一株羊伪结核棒状杆菌.中国畜禽传染病,1994(2):31-32
177. 赵宏坤,李光辉等.羊伪结核棒状杆菌的药敏试验.中国畜禽传染病,1995(5),12-13
178. 赵宏坤,平栋孝志.用协同溶血试验鉴定羊伪结核杆菌.中国畜禽传染病,1994(3),42-42
179. 赵宏坤,王春芬等.穴位注射法治疗羊伪结核病试验.中国畜禽传染病,1995(5),37-39
180. 赵宏坤,王春芬等.用菌体凝集抑制试验诊断羊伪结核病.中国畜禽传染病，1996(1)：36-37
181. 赵宏坤,范伟兴等.羊伪结核病研究进展.中国预防兽医学报,2000,22(3):236-237
182. 赵宏坤,戈永军.利福平在脓肿病灶内的残效期及其耐受菌株的分离鉴定.中国预防兽医学
报.2000,22(3):218-219
183. 赵宏坤,久枝,平栋等,用 ELISA 诊断伪结核的方法的建立.日本兽医师会杂志,1987（4）:281-285
184. 赵宏坤,周纬武,吉增福等.内蒙古东部地区羊伪结核病调查,中国畜禽传染病,1995,(4):13-14
185. 朱立平,陈学清.免疫学常用实验方法.北京：人民军医出版社,2000,342-355
51:141-148
2. Afzal M, Sakir M, Hussain MM. Corynebacterium pseudotuberculosis infection and lymphadenitis
(taloa or mala) in the camel. Trop Anim Health Prod. 1996 May;28(2):158-62.
3. Aleman M, Spier SJ, Wilson WD, Doherr M. Corynebacterium pseudotuberculosis infection in horses:
538 cases (1982-1993). J Am Vet Med Assoc. 1996 Aug 15;209(4):804-9.
4. Alonso JL, Simon MC, Girones O, Muzquiz JL, Ortega C, Garcia J. The effect of experimental
infection with Corynebacterium pseudotuberculosis on reproduction in adult ewes. Res Vet Sci. 1992
May;52(3):267-72.
5. al-Rawashdeh OF, al-Qudah KM. Effect of shearing on the incidence of caseous lymphadenitis in
Awassi sheep in Jordan. J Vet Med B Infect Dis Vet Public Health. 2000 May;47(4):287-93.
6. Arsenault J, Girard C, Dubreuil P, Daignault D, Galarneau JR, Boisclair J,Simard C, Belanger D.
Prevalence of and carcass condemnation from maedi-visna, paratuberculosis and caseous
lymphadenitis in culled sheep from Quebec, Canada. Prev Vet Med. 2003 May 30;59(1-2):67-81.
7. Ashfaq MK, Campbell SG. Experimentally induced caseous lymphadenitis in goats. Am J Vet Res.
1980 Nov;41(11):1789-92.
8. Barksdale L, Linder R, Sulea IT, Pollice M. Phospholipase D activity of Corynebacterium
pseudotuberculosis (Corynebacterium ovis) and Corynebacterium ulcerans, a distinctive marker within
the genus Corynebacterium.J Clin Microbiol. 1981 Feb;13(2):335-43.
9. Bartolome J, Roca MJ, Marcote E, Moreno R. Corynebacterium pseudotuberculosis adenitis in a
shepherd Med Clin (Barc). 1995 May 13;104(18):699-701.
10. Batcy RG. Aspects of pathogenesis in a mouse model of infection by Corynebacterium
pseudotuberculosis. Aust J Exp Biol Med Sci. 1986 Jun;64 ( Pt 3):237-49.
11. Billington SJ, Esmay PA, Songer JG, Jost BH. Identification and role in virulence of putative iron
acquisition genes from Corynebacterium pseudotuberculosis. FEMS Microbiol Lett. 2002 Feb
19;208(1):41-5.
12. Binns SH, Bailey M, Green LE. Postal survey of ovine caseous lymphadenitis in the United Kingdom
between 1990 and 1999. Vet Rec. 2002 Mar 2;150(9):263-8.
13. Braithwaite CE, Smith EE, Songer JG, Reine AH. Characterization of detergent-soluble proteins of
Corynebacterium pseudotuberculosis. Vet Microbiol. 1993 Dec;38(1-2):59-70.
14. Braverman Y, Chizov-Ginzburg A, Saran A, Winkler M. The role of houseflies (Musca domestica) in
harbouring Corynebacterium pseudotuberculosis in dairy herds in Israel. Rev Sci Tech. 1999
Dec;18(3):681-90.
36 羊干酪样淋巴结炎诊断方法的研究
15. Bregenzer T, Frei R, Ohnacker H, Zimmerli W. Corynebacterium pseudotuberculosis infection in a
butcher. Clin Microbiol Infect. 1997 Feb;3(6):696-698.
16. Brogden KA, Chedid L, Cutlip RC, Lehmkuhl HD, Sacks J. Effect of muramyl dipeptide on
immunogenicity of Corynebacterium pseudotuberculosis whole-cell vaccines in mice and lambs. Am J
Vet Res. 1990 Feb;51(2):200-2.
17. Brogden KA, Cutlip RC, Lehmkuhl HD. Experimental Corynebacterium pseudotuberculosis infection
in lambs. Am J Vet Res. 1984 Aug;45(8):1532-4.
18. Brogden KA, Engen RL, Songer JG, Gallagher J. Changes in ovine erythrocyte morphology due to
sphingomyelin degradation by Corynebacterium pseudotuberculosis phospholipase D. Microb Pathog.
1990 Feb;8(2):157-62.
19. Brogden KA, Engen RL. Alterations in the phospholipid composition and morphology of ovine
erythrocytes after intravenous inoculation of Corynebacterium pseudotuberculosis. Am J Vet Res.
1990 Jun;51(6):874-7.
20. Brown CC, Olander HJ, Biberstein EL, Moreno D. Serologic response and lesions in goats
experimentally infected with Corynebacterium pseudotuberculosis of caprine and equine origins. Am J
Vet Res. 1985 Nov;46(11):2322-6.
21. Brown CC, Olander HJ, Biberstein EL, Morse SM. Use of a toxoid vaccine to protect goats against
intradermal challenge exposure to Corynebacterium pseudotuberculosis. Am J Vet Res. 1986
May;47(5):1116-9.
22. Brown CC, Olander HJ, Zometa C, Alves SF. Serodiagnosis of inapparent caseous lymphadenitis in
goats and sheep, using the synergistic hemolysis-inhibition test. Am J Vet Res. 1986 Jul;47(7):1461-3.
23. Brumbaugh GW, Ekman TL. Corynebacterium pseudotuberculosis bacteremia in two horses. J Am Vet
Med Assoc. 1981 Feb 1;178(3):300-1.
24. Cameron CM, Bester FJ. An improved Corynebacterium pseudotuberculosis vaccine for sheep.
Onderstepoort J Vet Res. 1984 Dec;51(4):263-7.
25. Cetinkaya B, Karahan M, Atil E, Kalin R, De Baere T, Vaneechoutte M. Identification of
Corynebacterium pseudotuberculosis isolates from sheep and goats by PCR. Vet Microbiol. 2002 Aug
2;88(1):75-83.
26. Chaplin PJ, De Rose R, Boyle JS, McWaters P, Kelly J, Tennent JM, Lew AM, Scheerlinck JP.
Targeting improves the efficacy of a DNA vaccine against Corynebacterium pseudotuberculosis in
sheep. Infect Immun. 1999 Dec;67(12):6434-8.
27. Connor KM, Quirie MM, Baird G, Donachie W. Characterization of United Kingdom isolates of
Corynebacterium pseudotuberculosis using pulsed-field gel electrophoresis. J Clin Microbiol. 2000
Jul;38(7):2633-7.
28. Costa LR, Spier SJ, Hirsh DC. Comparative molecular characterization of Corynebacterium
参考文献 37
pseudotuberculosis of different origin. Vet Microbiol. 1998 May;62(2):135-43.
29. Cuevas WA, Songer JG. Arcanobacterium haemolyticum phospholipase D is genetically and
functionally similar to Corynebacterium pseudotuberculosis phospholipase D. Infect Immun. 1993
Oct;61(10):4310-6.
30. De Rose R, Tennent J, McWaters P, Chaplin PJ, Wood PR, Kimpton W, Cahill R,Scheerlinck JP.
Efficacy of DNA vaccination by different routes of immunisation in sheep. Vet Immunol
Immunopathol. 2002 Nov;90(1-2):55-63.
31. Dercksen DP, Brinkhof JM, Dekker-Nooren T, Maanen K, Bode CF, Baird G, Kamp EM. A comparison
of four serological tests for the diagnosis of caseous lymphadenitis in sheep and goats. Vet Microbiol.
2000 Jul 31;75(2):167-75.
32. Dercksen DP, ter Laak EA, Schreuder BE. Eradication programme for caseous lymphadenitis in goats
in The Netherlands. Vet Rec. 1996 Mar 9;138(10):237.
33. Dmitriev AV, Smola J, Shalen K, Golubkov VI, Totolian AA. The cloning and expression of the
phospholipase D gene from Corynebacterium pseudotuberculosis Zh Mikrobiol Epidemiol Immunobiol.
1994 Jul-Aug;(4):24-8.
34. Doherr MG, Carpenter TE, Hanson KM, Wilson WD, Gardner IA. Risk factors associated with
Corynebacterium pseudotuberculosis infection in California horses. Prev Vet Med. 1998 Jun
30;35(4):229-39.
35. Doherr MG, Carpenter TE, Wilson WD, Gardner IA. Application and evaluation of a mailed
questionnaire for an epidemiologic study of Corynebacterium pseudotuberculosis infection in horses.
Prev Vet Med. 1998 Jun 30;35(4):241-53.
36. Doherr MG, Carpenter TE, Wilson WD, Gardner IA. Effect of different sampling techniques on odds
ratio estimates using hospital-based cases and controls. Prev Vet Med. 1997 Sep;32(1-2):77-93.
37. Doherr MG, Carpenter TE, Wilson WD, Gardner IA. Evaluation of temporal and spatial clustering of
horses with Corynebacterium pseudotuberculosis infection. Am J Vet Res. 1999 Mar;60(3):284-91.
38. Egen NB, Cuevas WA, McNamara PJ, Sammons DW, Humphreys R, Songer JG. Purification of the
phospholipase D of Corynebacterium pseudotuberculosis by recycling isoelectric focusing. Am J Vet
Res. 1989 Aug;50(8):1319-22.
39. Eggleton DG, Haynes JA, Middleton HD, Cox JC. Immunisation against ovine caseous lymphadenitis:
correlation between Corynebacterium pseudotuberculosis toxoid content and protective efficacy in
combined clostridial-corynebacterial vaccines. Aust Vet J. 1991 Oct;68(10):322-5.
40. Eggleton DG, Middleton HD, Doidge CV, Minty DW. Immunisation against ovine caseous
lymphadenitis: comparison of Corynebacterium pseudotuberculosis vaccines with and without bacterial
cells. Aust Vet J. 1991 Oct;68(10):317-9.
41. Ellis JA, Campos M, Snyder M, Chelak B, Haines DM. Local production of tumor necrosis
38 羊干酪样淋巴结炎诊断方法的研究
factor-alpha in corynebacterial pulmonary lesions in sheep. Vet Pathol. 1995 Jan;32(1):68-71.
42. Ellis JA, Hawk DA, Holler LD, Mills KW, Pratt DL. Differential antibody responses to
Corynebacterium pseudotuberculosis in sheep with naturally acquired caseous lymphadenitis. J Am Vet
Med Assoc. 1990 May 15;196(10):1609-13.
43. Ellis JA, Hawk DA, Mills KW, Pratt DL. Antigen specificity and activity of ovine antibodies induced
by immunization with Corynebacterium pseudotuberculosis culture filtrate. Vet Immunol
Immunopathol. 1991 Jul;28(3-4):303-16.
44. Ellis JA, Hawk DA, Mills KW, Pratt DL. Antigen specificity of antibody responses to Corynebacterium
pseudotuberculosis in naturally infected sheep with caseous lymphadenitis. Vet Immunol
Immunopathol. 1991 Jul;28(3-4):289-301.
45. Ellis JA, Russell HI, Du CW. Effect of selected cytokines on the replication of Corynebacterium
pseudotuberculosis and ovine lentiviruses in pulmonary macrophages. Vet Immunol Immunopathol.
1994 Jan;40(1):31-47.
46. Ellis TM, Sutherland SS, Wilkinson FC, Mercy AR, Paton MW. The role of Corynebacterium
pseudotuberculosis lung lesions in the transmission of this bacterium to other sheep. Aust Vet J. 1987
Sep;64(9):261-3.
47. Garg DN, Chandiramani NK. Cellular and humoral immune responses in sheep experimentally injected
with killed and live Corynebacterium pseudotuberculosis. Zentralbl Bakteriol Mikrobiol Hyg [A]. 1985
Aug;260(1):117-25.
48. Glass EN, De Lahunta A, Jackson C. Brain abscess in a goat. Cornell Vet. 1993 Oct;83(4):275-82.
49. H.Meyer，et al:1992,Rapid identification and differentiation of the vaccinestrain Rae H from EHV-1
field isolates using a non- radioactive DNA probe ,Vet. Microl., 30:13 一 20.
50. Hatfield, R.M. ,B. A. Morris. And R. R. Henry. Development of an Enzyme-linked Immunosorbent
Assay for the detection of humoral antibody to pasteurella anatipestifer[J]. Avian pathology, 1987，
16:123 一 140
51. Haynes JA, Tkalcevic J, Nisbet IT. Production of an enzymatically inactive analog of phospholipase D
from Corynebacterium pseudotuberculosis. Gene. 1992 Sep 21;119(1):119-21.
52. Hebert GA, Hancock GA. Synergistic hemolysis exhibited by species of staphylococci. J Clin
Microbiol. 1985 Sep;22(3):409-15.
53. Hermoso De Mendoza J, Nieto CG, Arenas A, Alonso JM, Rey J, Gil MC, Anton J, Cardenal A,
Hermoso De Mendoza M. An indirect fluorescent antibody technique for detection of
anti-Dermatophilus congolensis antibodies in sheep. Trop Anim Health Prod. 1994 May;26(2):74-8.
54. Herrera-Alcaraz E, Valero-Guillen P, Martin-Luengo F, Canteras-Jordana M. Numerical analysis of
fatty and mycolic acid profiles of Corynebacterium urealyticum and other related corynebacteria.
Microbiologia. 1993 Apr;9(1):53-62.
参考文献 39
55. Hodgson AL, Bird P, Nisbet IT. Cloning, nucleotide sequence, and expression in Escherichia coli of the
phospholipase D gene from Corynebacterium pseudotuberculosis. J Bacteriol. 1990
Mar;172(3):1256-61.
56. Hodgson AL, Carter K, Tachedjian M, Krywult J, Corner LA, McColl M, Cameron A. Efficacy of an
ovine caseous lymphadenitis vaccine formulated using a genetically inactive form of the
Corynebacterium pseudotuberculosis phospholipase D. Vaccine. 1999 Feb 26;17(7-8):802-8.
57. Hodgson AL, Krywult J, Corner LA, Rothel JS, Radford AJ. Rational attenuation of Corynebacterium
pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle. Infect Immun. 1992
Jul;60(7):2900-5.
58. Hodgson AL, Tachedjian M, Corner LA, Radford AJ. Protection of sheep against caseous
lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis.
Infect Immun. 1994 Dec;62(12):5275-80.
59. Holstad G, Teige J Jr, Larsen HJ. Corynebacterium pseudotuberculosis infection in goats. VIII. The
effect of vaccination against experimental infection. Acta Vet Scand. 1989;30(3):275-83.
60. Holstad G, Teige J Jr. Corynebacterium pseudotuberculosis infection in goats. VII. Clinical,
pathological, serological and hematological changes after subcutaneous inoculation of the organism.
Acta Vet Scand. 1988;29(3-4):287-94.
61. Holstad G. Corynebacterium pseudotuberculosis infection in goats. IX. The effect of vaccination
against natural infection. Acta Vet Scand. 1989;30(3):285-93.
62. Holstad G. Corynebacterium pseudotuberculosis infection in goats. V. Relationship between the
infection and lesions resulting from vaccination against paratuberculosis. Acta Vet Scand.
1986;27(4):617-22.
63. Holstad G. Corynebacterium pseudotuberculosis infection in goats. IV. Course of the infection in two
recently infected goat herds. Acta Vet Scand. 1986;27(4):609-16.
64. Holstad G. Corynebacterium pseudotuberculosis infection in goats. III. The influence of age. Acta Vet
Scand. 1986;27(4):598-608.
65. Holstad G. Corynebacterium pseudotuberculosis infection in goats. II. The prevalence of caseous
lymphadenitis in 36 goat herds in Northern Norway. Acta Vet Scand. 1986;27(4):584-97.
66. Hommez J, Devriese LA, Vaneechoutte M, Riegel P, Butaye P, Haesebrouck F. Identification of
nonlipophilic corynebacteria isolated from dairy cows with mastitis. J Clin Microbiol. 1999
Apr;37(4):954-7.
67. Hsu TY, Renshaw HW, Livingston CW Jr, Augustine JL, Zink DL, Gauer BB. Corynebacterium
pseudotuberculosis exotoxin: fatal hemolytic anemia induced in gnotobiotic neonatal small ruminants
by parenteral administration of preparations containing exotoxin. Am J Vet Res. 1985
May;46(5):1206-11.
40 羊干酪样淋巴结炎诊断方法的研究
68. Hudson，G.C., et al:1988, lndentification and location of a gene in equine herpesvirus 一 1analogous to
the major glyeoprotein gB of herpes simplex vius .proceedings .V. lntermational Conference Equine
Infectious，Kentucky，USA, 111 一 117.
69. Ioneda T. Chromatographic and mass spectrometric characterization of 3-O-benzoyl methyl ester
derivatives of mycolic acid fractions from Corynebacterium pseudotuberculosis, C. diphtheriae and
Rhodococcus rhodochrous. Chem Phys Lipids. 1993 Jun;65(2):93-101.
70. Ioneda T. Mass spectrometric analysis of O-peracetylated derivatives of1-monomycoloylglycerol
isolated from Corynebacterium pseudotuberculosis, Rhodococcus rhodochrous and R. lentifragmentus.
Chem Phys Lipids. 1990 Jun;54(3-4):215-20.
71. Judson R, Songer JG. Corynebacterium pseudotuberculosis: in vitro susceptibility to 39 antimicrobial
agents. Vet Microbiol. 1991 Apr;27(2):145-50.
72. Kaba J, Kutschke L, Gerlach GF. Development of an ELISA for the diagnosis of Corynebacterium
pseudotuberculosis infections in goats. Vet Microbiol. 2001 Jan 26;78(2):155-63.
73. Keslin MH, McCoy EL, McCusker JJ, Lutch JS. Corynebacterium pseudotuberculosis. A new cause of
infectious and eosinophilic pneumonia. Am J Med. 1979 Aug;67(2):228-31.
74. Kuria JK, Holstad G. A seroepidemiological investigation of Corynebacterium pseudotuberculosis
infection in sheep flocks in southern Norway. Acta Vet Scand. 1989;30(1):107-8.
75. Kuria JK, Holstad G. Serological investigation of Corynebacterium pseudotuberculosis infection in
sheep--correlation between the hemolysis inhibition test and the ELISA test. Acta Vet Scand.
1989;30(1):109-10.
76. Kuria JK, Mbuthia PG, Kang'ethe EK, Wahome RG. Caseous lymphadenitis in goats: the pathogenesis,
incubation period and serological response after experimental infection. Vet Res Commun. 2001
Feb;25(2):89-97.
77. Kutschke L, Ganter M, Kaba J. Efficacy of a flock-specific pseudotuberculosis vaccine in goats. Dtsch
Tierarztl Wochenschr. 2000 Dec;107(12):495-500.
78. Lan DT, Makino S, Shirahata T, Yamada M, Nakane A. Tumor necrosis factor alpha and gamma
interferon are required for the development of protective immunity to secondary Corynebacterium
pseudotuberculosis infection in mice. J Vet Med Sci. 1999 Nov;61(11):1203-8.
79. Lan DT, Makino S, Shirahata T, Yamada M, Nakane. Complement receptor type 3 plays an important
role in development of protective immunity to primary and secondary Corynebacterium
pseudotuberculosis infection in mice. Microbiol Immunol. 1999;43(12):1103-6.
80. Lan DT, Taniguchi S, Makino S, Shirahata T, Nakane A. Role of endogenous tumor necrosis factor
alpha and gamma interferon in resistance to Corynebacterium pseudotuberculosis infection in mice.
Microbiol Immunol. 1998;42(12):863-70.
81. LeaMaster BR, Shen DT, Gorham JR, Leathers CW, Wells HD. Efficacy of Corynebacterium
参考文献 41
pseudotuberculosis bacterin for the immunologic protection of sheep against development of caseous
lymphadenitis. Am J Vet Res. 1987 May;48(5):869-72.
82. Lester WA, Schousboe M, Chambers S, Patton WN. A second case of Corynebacterium
pseudotuberculosis in New Zealand. N Z Med J. 1997 Dec 12;110(1057):469-70.
83. Lund A, Almlid T, Larsen HJ, Steine T. Antibodies to Corynebacterium pseudotuberculosis in adult
goats from a naturally infected herd. Acta Vet Scand. 1982;23(4):473-82.
84. Maki LR, Shen SH, Bergstrom RC, Stetzenbach LD. Diagnosis of Corynebacterium
pseudotuberculosis infections in sheep, using an enzyme-linked immunosorbent assay. Am J Vet Res.
1985 Jan;46(1):212-4.
85. McNamara PJ, Bradley GA, Songer JG. Targeted mutagenesis of the phospholipase D gene results in
decreased virulence of Corynebacterium pseudotuberculosis. Mol Microbiol. 1994 Jun;12(6):921-30.
86. McNamara PJ, Cuevas WA, Songer JG. Toxic phospholipases D of Corynebacterium
pseudotuberculosis, C. ulcerans and Arcanobacterium haemolyticum: cloning and sequence homology.
Gene. 1995 Apr 14;156(1):113-8.
87. Menzies PI, Muckle CA, Brogden KA, Robinson L. A field trial to evaluate a whole cell vaccine for
the prevention of caseous lymphadenitis in sheep and goat flocks. Can J Vet Res. 1991
Oct;55(4):362-6.
88. Menzies PI, Muckle CA. The use of a microagglutination assay for the detection of antibodies to
Corynebacterium pseudotuberculosis in naturally infected sheep and goat flocks. Can J Vet Res. 1989
Jul;53(3):313-8.
89. Mills AE, Mitchell RD, Lim EK. Corynebacterium pseudotuberculosis is a cause of human necrotising
granulomatous lymphadenitis. Pathology. 1997 May;29(2):231-3.
90. Moller K, Agerholm JS, Ahrens P, Jensen NE, Nielsen TK. Abscess disease, caseous lymphadenitis,
and pulmonary adenomatosis in imported sheep. J Vet Med B Infect Dis Vet Public Health. 2000
Feb;47(1):55-62.
91. Moore RJ, Rothel L, Krywult J, Radford AJ, Lund K, Hodgson AL. Foreign gene expression in
Corynebacterium pseudotuberculosis: development of a live vaccine vector. Vaccine. 1999 Oct
14;18(5-6):487-97.
92. Moore RJ, Stewart DJ, Lund K, Hodgson AL. Vaccination against ovine footrot using a live bacterial
vector to deliver basic protease antigen. FEMS Microbiol Lett. 2001 Jan 15;194(2):193-6.
93. Muckle CA, Gyles CL. Characterization of strains of corynebacterium pseudotuberculosis. Can J
Comp Med. 1982 Apr;46(2):206-8.
94. Muckle CA, Gyles CL. Relation of lipid content and exotoxin production to virulence of
Corynebacterium pseudotuberculosis in mice. Am J Vet Res. 1983 Jun;44(6):1149-53.
95. Muckle CA, Menzies PI, Li Y, Hwang YT, van Wesenbeeck M. Analysis of the immunodominant
42 羊干酪样淋巴结炎诊断方法的研究
antigens of Corynebacterium pseudotuberculosis. Vet Microbiol. 1992 Jan;30(1):47-58.
96. Ndikuwera J, Odiawo GO, Usenik EA, Kock ND, Ogaa JS, Kuiper. Chronic contagious ecthyma and
caseous lymphadenitis in two Boer goats. Vet Rec. 1992 Dec 19-26;131(25-26):584-5.
97. Nord K, Holstad G, Eik LO, Gronstol H. Control of caprine arthritis-encephalitis virus and
Corynebacterium pseudotuberculosis infection in a Norwegian goat herd. Acta Vet Scand.
1998;39(1):109-17.
98. Olson ME, Ceri H, Morck DW, Buret AG, Read RR. Biofilm bacteria: formation and comparative
susceptibility to antibiotics. Can J Vet Res. 2002 Apr;66(2):86-92.
99. Onovian, O. et. al. Detection of antibody against M. mycoides subspmycoides in cattle by an
enzyme-linked immunosorbent assay[J]. Veterinary Record, 1979,105:165 一 167.
100. Paton MW, Buller NB, Rose IR, Ellis TM. Effect of the interval between shearing and dipping on the
spread of Corynebacterium pseudotuberculosis infection in sheep. Aust Vet J. 2002 Aug;80(8):494-6.
101. Paton MW, Mercy AR, Sutherland SS, Ellis TM, Duda SR. The effect of antibody to caseous
lymphadenitis in ewes on the efficacy of Aust Vet J. 1991 Apr;68(4):143-6.
102. Paton MW, Mercy AR, Wilkinson FC, Gardner JJ, Sutherland SS, Ellis TM. The effects of caseous
lymphadenitis on wool production and bodyweight in young Aust Vet J. 1988 Apr;65(4):117-9.
103. Paton MW, Rose IR, Hart RA, Sutherland SS, Mercy AR, Ellis TM, Dhaliwal JA. New infection with
Corynebacterium pseudotuberculosis reduces wool production. Aust Vet J. 1994 Feb;71(2):47-9.
104. Paton MW, Sutherland SS, Rose IR, Hart RA, Mercy AR, Ellis TM. The spread of Corynebacterium
pseudotuberculosis infection to unvaccinated and vaccinated sheep. Aust Vet J. 1995 Jul;72(7):266-9.
105. Peel MM, Palmer GG, Stacpoole AM, Kerr TG. Human lymphadenitis due to Corynebacterium
pseudotuberculosis: report of ten cases from Australia and review. Clin Infect Dis. 1997
Feb;24(2):185-91.
106. Pepin M, Bernard S, Menanteau P, Olivier M, Berthon P, Lantier F. Reactivity of workshop
monoclonal antibodies with normal and pathological ovine lymph nodes. Vet Immunol Immunopathol.
1993 Nov;39(1-3):249-67.
107. Pepin M, Boisrame A, Marly J. Corynebacterium pseudotuberculosis: biochemical properties,
production of toxin and virulence of ovine and caprine strains. Ann Rech Vet. 1989;20(1):111-5.
108. Pepin M, Fontaine JJ, Pardon P, Marly J, Parodi AL. Histopathology of the early phase during
experimental Corynebacterium pseudotuberculosis infection in lambs. Vet Microbiol. 1991
Oct;29(2):123-34.
109. Pepin M, Pardon P, Lantier F, Marly J, Levieux D, Lamand M. Experimental Corynebacterium
pseudotuberculosis infection in lambs: kinetics of bacterial dissemination and inflammation. Vet
Microbiol. 1991 Feb 15;26(4):381-92.
110. Pepin M, Pardon P, Marly J, Lantier F, Arrigo JL. Acquired immunity after primary caseous
参考文献 43
lymphadenitis in sheep. Am J Vet Res. 1993 Jun;54(6):873-7.
111. Pepin M, Pardon P, Marly J, Lantier F. Corynebacterium pseudotuberculosis infection in adult ewes by
inoculation in the external ear. Am J Vet Res. 1988 Apr;49(4):459-63.
112. Pepin M, Pittet JC, Olivier M, Gohin I. Cellular composition of Corynebacterium pseudotuberculosis
pyogranulomas in sheep. J Leukoc Biol. 1994 Nov;56(5):666-70.
113. Pepin M, Seow HF, Corner L, Rothel JS, Hodgson AL, Wood PR. Cytokine gene expression in sheep
following experimental infection with various strains of Corynebacterium pseudotuberculosis differing
in virulence. Vet Res. 1997;28(2):149-63.
114. Piontkowski MD, Shivvers DW. Evaluation of a commercially available vaccine against
Corynebacterium pseudotuberculosis for use in sheep. J Am Vet Med Assoc. 1998 Jun
1;212(11):1765-8.
115. Pittet JC, Pepin M, Normier G, Binz H, Le Pape A. Lymphoscintigraphy via the targeting of
macrophages with 99mTc-J001X poly-galactoside in a model of pyogranulomas developed in sheep
lymph nodes. Nucl Med Biol. 1995 Apr;22(3):355-65.
116. Pogson CA, Simmons CP, Strugnell RA, Hodgson AL. Cloning and manipulation of the
Corynebacterium pseudotuberculosis recA gene for live vaccine vector development. FEMS
Microbiol Lett. 1996 Sep 1;142(2-3):139-45.
117. Poonacha KB, Donahue JM. Abortion in a mare associated with Corynebacterium pseudotuberculosis
infection. J Vet Diagn Invest. 1995 Oct;7(4):563-4.
118. Prescott JF, Menzies PI, Hwang YT. An interferon-gamma assay for diagnosis of Corynebacterium
pseudotuberculosis infection in adult sheep from a research flock. Vet Microbiol. 2002 Sep
2;88(3):287-97.
119. Prodhan MA, Olander HJ, Gardner IA. A comparison of dot-blot assay with the synergistic haemolytic
inhibition test in goats naturally infected with Corynebacterium pseudotuberculosis. Vet Res Commun.
1993;17(3):193-6.
120. Pusterla N, Watson JL, Affolter VK, Magdesian KG, Wilson WD, Carlson GP. Purpura haemorrhagica
in 53 horses. Vet Rec. 2003 Jul 26;153(4):118-21.
121. Radwan AI, el-Magawry S, Hawari A, al-Bekairi SI, Rebleza RM. Corynebacterium
pseudotuberculosis infection in camels (Camelus dromedarius) in Saudi Arabia. Trop Anim Health
Prod. 1989 Nov;21(4):229-30.
122. Renshaw HW, Graff VP, Gates NL. Visceral caseous lymphadenitis in thin ewe syndrome: isolation of
Corynebacterium, Staphylococcus, and Moraxella spp from internal abscesses in emaciated ewes. Am J
Vet Res. 1979 Aug;40(8):1110-1126
123. Richards M, Hurse A. Corynebacterium pseudotuberculosis abscesses in a young butcher. Aust N Z J
Med. 1985 Feb;15(1):85-6.
44 羊干酪样淋巴结炎诊断方法的研究
124. Rothel JS, Hurst L, Seow HF, Pepin M, Berthon P, Corner LA, Wood PR. Analysis of ovine IL-1 beta
production in vivo and in vitro by enzyme immunoassay and immunohistochemistry. Vet Immunol
Immunopathol. 1997 Jul;57(3-4):267-78.
125. Schreuder BE, Ter Laak EA, De Gee AL. Corynebacterium pseudotuberculosis in milk of CL affected
goats. Vet Rec. 1990 Oct 13;127(15):387.
126. Schreuder BE, ter Laak EA, Dercksen DP. Eradication of caseous lymphadenitis in sheep with the help
of a newly developed ELISA technique. Vet Rec. 1994 Aug 20;135(8):174-6.
127. Scott PR, Collie DD, Hume LH. Caseous lymphadenitis in a commercial ram stud in Scotland. Vet
Rec. 1997 Nov 22;141(21):548-9.
128. Serikawa S, Ito S, Hatta T, Kusakari N, Senna K, Hiramune T, Kikuchi N, Yanagawa R. Protection
from caseous lymphadenitis in sheep by spraying iodine tincture on shearing wounds. J Vet Med Sci.
1994 Apr;56(2):411-2.
129. Serikawa S, Ito S, Hatta T, Kusakari N, Senna K, Sawara S, Hiramune T, Kikuchi N, Yanagawa R.
Seroepidemiological evidence that shearing wounds are mainly responsible for Corynebacterium
pseudotuberculosis infection in sheep. J Vet Med Sci. 1993 Aug;55(4):691-2.
130. Shpigel NY, Elad D, Yeruham I, Winkler M, Saran A. An outbreak of Corynebacterium
pseudotuberculosis infection in an Israeli dairy herd. Vet Rec. 1993 Jul 24;133(4):89-94.
131. Shulaw WP, Bech-Nielsen S, Rings DM, Getzy DM, Woodruff TS. Serodiagnosis of paratuberculosis
in sheep by use of agar gel immunodiffusion. Am J Vet Res. 1993 Jan;54(1):13-9.
132. Simmons CP, Dunstan SJ, Tachedjian M, Krywult J, Hodgson AL, Strugnell RA. Vaccine potential of
attenuated mutants of Corynebacterium pseudotuberculosis in sheep. Infect Immun. 1998
Feb;66(2):474-9.
133. Simmons CP, Hodgson AL, Strugnell RA. Attenuation and vaccine potential of aroQ mutants of
Corynebacterium pseudotuberculosis. Infect Immun. 1997 Aug;65(8):3048-56.
134. Skalka B, Literak I, Chalupa P, Votava M. Phospholipase D-neutralization in serodiagnosis of
Arcanobacterium haemolyticum and Corynebacterium pseudotuberculosis infections. Zentralbl
Bakteriol. 1998 Dec;288(4):463-70.
135. Skalka B, Literak I, Michalik I, Skrivanek M. Corynebacterium pseudotuberculosis infection in goats
in the Czech Republic. Zentralbl Veterinarmed B. 1998 Feb;45(1):31-5.
136. Skalka B, Literak I. Serodiagnosis of caseous lymphadenitis (pseudotuberculosis) in sheep Vet Med
(Praha). 1994;39(9):533-9.
137. Songer JG, Beckenbach K, Marshall MM, Olson GB, Kelley L. Biochemical and genetic
characterization of Corynebacterium pseudotuberculosis. Am J Vet Res. 1988 Feb;49(2):223-6.
138. Songer JG, Hilwig RW, Leeming MN, Iandolo JJ, Libby SJ. Transformation of Corynebacterium
pseudotuberculosis by electroporation. Am J Vet Res. 1991 Aug;52(8):1258-61.
参考文献 45
139. Songer JG, Libby SJ, Iandolo JJ, Cuevas WA. Cloning and expression of the phospholipase D gene
from Corynebacterium pseudotuberculosis in Escherichia coli. Infect Immun. 1990 Jan;58(1):131-6.
140. Stanford K, Brogden KA, McClelland LA, Kozub GC, Audibert F. The incidence of caseous
lymphadenitis in Alberta sheep and assessment of impact by vaccination with commercial and
experimental vaccines. Can J Vet Res. 1998 Jan;62(1):38-43.
141. Sting R, Steng G, Spengler D. Serological studies on Corynebacterium pseudotuberculosis infections
in goats using enzyme-linked immunosorbent assay. Zentralbl Veterinarmed B. 1998
May;45(4):209-16.
142. Sutherland SS, Ellis TM, Paton MJ, Mercy AR. Serological response of vaccinated sheep after
challenge with Corynebacterium pseudotuberculosis. Aust Vet J. 1992 Jul;69(7):168-9.
143. Sutherland SS, Hart RA, Buller NB. Genetic differences between nitrate-negative and nitrate-positive
C. pseudotuberculosis strains using restriction fragment length polymorphisms. Vet Microbiol. 1996
Mar;49(1-2):1-9.
144. Sutherland SS, Hart RA, Buller NB. Ribotype analysis of Corynebacterium pseudotuberculosis
isolates from sheep and goats. Aust Vet J. 1993 Dec;70(12):454-6.
145. Sutherland SS, Speijers EJ, Andres B. Comparison of the exotoxins of four strains of Corynebacterium
pseudotuberculosis. Res Vet Sci. 1989 Sep;47(2):190-4.
146. Synder, D. B. Rapid serological profiling by Enzyme-linked Immunosorbent Assay: measurement of
antibody activity titer against Newcastle Disease Virus in a single serum dilution[J]. Avian Diseases,
1983,270):161 一 170
147. Tachedjian M, Krywult J, Moore RJ, Hodgson AL. Caseous lymphadenitis vaccine development:
site-specif ic inactivation of the Corynebacterium pseudotuberculosis phospholipase D gene. Vaccine.
1995 Dec;13(18):1785-92.
148. Takahashi T, Mori Y, Kobayashi H, Ochi M, Kikuchi N, Hiramune T. Phylogenetic positions and
assignment of swine and ovine corynebacterial isolates based on the 16S rDNA sequence. Microbiol
Immunol. 1997;41(9):649-55.
149. Tambourgi DV, De Sousa Da Silva M, Billington SJ, Goncalves De Andrade RM,Magnoli FC, Songer
JG, Van Den Berg CW. Mechanism of induction of complement susceptibility of erythrocytes by spider
and bacterial sphingomyelinases. Immunology. 2002 Sep;107(1):93-101.
150. ter Laak EA, Bosch J, Bijl GC, Schreuder BE. Double-antibody sandwich enzyme-linked
immunosorbent assay and immunoblot analysis used for control of caseous lymphadenitis in goats and
sheep. Am J Vet Res. 1992 Jul;53(7):1125-32.
151. Unanian MM, Feliciano Silva AE, Pant KP. Abscesses and caseous lymphadenitis in goats in tropical
semi-arid north-east Brazil.Trop Anim Health Prod. 1985 Feb;17(1):57-62.
152. Vaneechoutte M, Riegel P, de Briel D, Monteil H, Verschraegen G, De Rouck A,Claeys G. Evaluation
46 羊干酪样淋巴结炎诊断方法的研究
of the applicability of amplified rDNA-restriction analysis (ARDRA) to identification of species of the
genus Corynebacterium. Res Microbiol. 1995 Oct;146(8):633-41.
153. Walker J, Jackson H, Brandon MR, Meeusen E. Lymphocyte subpopulations in pyogranulomas of
caseous lymphadenitis. Clin Exp Immunol. 1991 Oct;86(1):13-8.
154. Walker J, Jackson HJ, Eggleton DG, Meeusen EN, Wilson MJ, Brandon MR. Identification of a novel
antigen from Corynebacterium pseudotuberculosis that protects sheep against caseous lymphadenitis.
Infect Immun. 1994 Jun;62(6):2562-7.
155. Watson PJ, Preece BE. Report on 31 caseous lymphadenitis infected sheep farms in England and
Wales. Vet Rec. 2001 May 26;148(21):663-5.
156. Williamson LH. Caseous lymphadenitis in small ruminants. Vet Clin North Am Food Anim Pract.
2001 Jul;17(2):359-71, vii.
157. Wilson MJ, Brandon MR, Walker J. Molecular and biochemical characterization of a protective
40-kilodalton antigen from Corynebacterium pseudotuberculosis. Infect Immun. 1995
Jan;63(1):206-11.
158. Yeruham I, Braverman Y, Shpigel NY, Chizov-Ginzburg A, Saran A, Winkler M. Mastitis in dairy
cattle caused by Corynebacterium pseudotuberculosis and the feasibility of transmission by houseflies.
I. Vet Q. 1996 Sep;18(3):87-9.
159. Yeruham I, Elad D, Friedman S, Perl S. Corynebacterium pseudotuberculosis infection in Israeli dairy
cattle. Epidemiol Infect. 2003 Oct;131(2):9,147-55.
160. Yeruham I, Elad D, Perl S, Ram A. Necrotic-ulcerative dermatitis on the heels of heifers in a dairy
herd infected with Corynebacterium pseudotuberculosis. Vet Rec. 2003 May 10;152(19):598-600.
161. Yeruham I, Elad D, Van-Ham M, Shpigel NY, Perl S. Corynebacterium pseudotuberculosis infection in
Israeli cattle: clinical and epidemiological studies. Vet Rec. 1997 Apr 19;140(16):423-7.
162. Yozwiak ML, Songer JG. Effect of Corynebacterium pseudotuberculosis phospholipase D on viability
and chemotactic responses of ovine neutrophils. Am J Vet Res. 1993 Mar;54(3):392-7.
163. Zhang Y, Praszkier J, Hodgson A, Pittard AJ. Molecular analysis and characterization of a
broad-host-range plasmid, pEP2. J Bacteriol. 1994 Sep;176(18):5718-28.
164. Zhao HK, Hiramune T, Kikuchi N, Yanagawa R, Ito S, Hatta T, Serikawa S, Oe Y. Selective medium
containing fosfomycin, nalidixic acid, and culture supernatant of Rhodococcus equi for isolation of
Corynebacterium pseudotuberculosis. Zentralbl Veterinarmed B. 1991 Dec;38(10):743-8.
165. Zhao HK, Morimura H, Hiramune T, Kikuchi N, Yanagawa R, Serikawa S. Antimicrobial
susceptibility of Corynebacterium pseudotuberculosis isolated from lesions of caseous lymphadenitis
in sheep in Hokkaido, Japan. J Vet Med Sci. 1991 Apr;53(2):355-6.
166. Zhao HK, Yonekawa K, Takahashi T, Kikuchi N, Hiramune T, Yanagawa R. Isolation of
Corynebacterium pseudotuberculosis from the cervical canal of clinically normal sows. Res Vet Sci.
参考文献47
1993 Nov;55(3):356-9.
167. 郭在军等.骆驼伪结核棒状杆菌的诊断.中国畜禽传染病.1988,(2):33
168. 侯从远.山羊伪结核诊断报告.中国畜牧兽医,1962,(7):20-22.
169. 黄引贤,李乃津等.羊伪结核棒状杆菌某些特性的初步研究,1988,(2):3-4
170. 蒋成淦主编.酶免疫测定法.北京：人民卫生出版社.1984
171. 李福刚,袁玉国,聂春应等.奶山羊假结核棒状杆菌病的诊治.江西畜牧兽医杂.2002,(5):23-24
172. 李新泉等.莎能奶山羊假结核病净化报告.中国兽医杂志,1994,20,22-23
173. 史学增,尹慧春.鹿伪结核棒状杆菌病的研究近况.吉林畜牧兽医,1995,17(1):13-15
174. 汪家政,范明主编.蛋白质技术手册.北京：科学出版社.2001,65-67
175. 赵宏坤,敖力布.羊伪结核病免疫方法的研究.中国畜禽传染病,1996(5):29-32
176. 赵宏坤,吉增福.由溶解的山羊胎儿分离出一株羊伪结核棒状杆菌.中国畜禽传染病,1994(2):31-32
177. 赵宏坤,李光辉等.羊伪结核棒状杆菌的药敏试验.中国畜禽传染病,1995(5),12-13
178. 赵宏坤,平栋孝志.用协同溶血试验鉴定羊伪结核杆菌.中国畜禽传染病,1994(3),42-42
179. 赵宏坤,王春芬等.穴位注射法治疗羊伪结核病试验.中国畜禽传染病,1995(5),37-39
180. 赵宏坤,王春芬等.用菌体凝集抑制试验诊断羊伪结核病.中国畜禽传染病，1996(1)：36-37
181. 赵宏坤,范伟兴等.羊伪结核病研究进展.中国预防兽医学报,2000,22(3):236-237
182. 赵宏坤,戈永军.利福平在脓肿病灶内的残效期及其耐受菌株的分离鉴定.中国预防兽医学
报.2000,22(3):218-219
183. 赵宏坤,久枝,平栋等,用 ELISA 诊断伪结核的方法的建立.日本兽医师会杂志,1987（4）:281-285
184. 赵宏坤,周纬武,吉增福等.内蒙古东部地区羊伪结核病调查,中国畜禽传染病,1995,(4):13-14
185. 朱立平,陈学清.免疫学常用实验方法.北京：人民军医出版社,2000,342-355