内关、足三里穴共同调节心胃功能的中枢整合机制
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摘要
目的:通过比较针刺内关、足三里等穴对正常及模型大鼠孤束核(NTS)神经元放电、c-fos表达及胃内压、ST_Ⅱ的影响,探讨多病症一经(穴)司控,一脏(腑)多经(穴)调控的经脉—脏腑相关理论,阐明NTS可能是内关、足三里穴共同调节心胃功能的一个重要的延髓初级中枢。
方法:运用细胞外记录神经电生理学方法,研究针刺内关、足三里等穴对NTS神经元放电及对NTS胃扩张或心律失常敏感神经元放电的影响。运用免疫组织化学技术观察电针内关、足三里等穴对胃扩张或心肌缺血模型大鼠NTS内c-fos表达的影响。
结果:1、针刺足三里、内关、偏历、合阳穴各组,NTS内神经元主要以呈兴奋性反应为主。针刺足三里、内关穴组,NTS内兴奋性神经元出现率与针刺偏历、合阳穴组比较有显著性差异(P＜0.01)。选取对针刺腧穴呈兴奋性反应的NTS神经元,比较针刺前后神经元放电频率变化。针刺足三里、内关、偏历、合阳穴组,其针刺后放电频率均显著高于针刺前(P＜0.01),表明针刺对NTS神经元有明显的激活作用;针刺足三里穴组、内关穴组兴奋性神经元频率变化率显著高于针刺偏历、合阳穴组(P＜0.01)。
2、①149个NTS神经元中对胃扩张刺激起反应的有65个,其中44个神经元(44/65)被胃扩张刺激所兴奋,21个神经元(21/65)被胃扩张刺激所抑制,NTS神经元对胃扩张刺激以呈兴奋性反应为主。针刺足三里、内夭、偏历、合阳穴各组,NTS胃扩张兴奋性神经元主要呈抑制性反应。针刺足三里、内关穴组,NTS胃扩张兴奋性神经元呈抑制反应的出现率显著高于针刺偏历、合阳穴组(P＜0.01或P＜0.05)。针刺足三里、内关、偏历、合阳穴组,均可使胃扩张模型大鼠NTS兴奋性神经元放电频率显著降低(P＜0.01)。针刺足三里、肉关穴组NTS胃扩张兴奋性神经元频率变化率显著高于针刺偏历、合阳穴组(P＜0.01)。
②116个NTS神经元中对心律失常刺激起反应的有54个,其中46个神经元(46/54)被心律失常刺激所抑制,8个神经元(8/54)被心律失常刺激所兴奋。NTS神经元对乌头碱造成心律失常刺激以呈抑制性反应为主。针刺足三里、内关、偏历、合阳穴各组,NTS心律失常抑制性神经元主要呈兴奋性反应。针刺内关穴组,NTS心律失常抑制性神经元呈兴奋反应的出现率显著高于针刺偏历、合阳穴组(P＜0.05)。针刺足三里、内关、偏历、合阳穴组,均可使心律失常模型大鼠NTS抑制性神经元放电频率显著增加(P＜0.01)。针刺足三里、内关穴组NTS心律失常抑制性神经元频率变化率显著高于针刺偏历、合阳穴组(P＜0.01)。
3、①造成大鼠胃扩张模型后,能显著诱导NTS内c-fos的表达;电针足三里、内关穴组与胃扩张模型组比较,NTS内Fos阳性细胞数均有显著性降低(P＜0.01);电针足三里、内关穴组NTS内Fos阳性细胞数显著低于电针偏历、合阳穴组(P＜0.01)。②造成大鼠心肌缺血模型后,能显著诱导NTS内c-fos的表达;电针足三里、内关穴组与心肌缺血模型组比较,NTS内Fos阳性细胞数均有显著性降低(P＜0.01);电针足三里、内关穴组NTS内Fos阳性细胞数显著低于电针偏历、合阳穴组(P＜0.01)。
4、①电针足三里、内关穴组能显著升高胃扩张模型大鼠胃内压(P＜0.01),其胃内压升高程度高于电针偏历、合阳穴组(P＜0.01)。②电针足三里、内关穴组能显著降低心肌缺血模型大鼠ST_Ⅱ电位值(P＜0.01),其电位降低值大于电针偏历、合阳穴组(P＜0.01)。
结论:1、针刺内关、足三里穴区的躯体感觉传入和心胃的内脏伤害性刺激传入在NTS发生汇聚。2、NTS是针刺内关、足三里穴共同调节心胃功能的整合中枢之一。3、多病症一经(穴)司控,一脏(腑)多经(穴)调控具有相对的特异性。
Objective:To explore the mechanism of "one meridian or acupoint controlling many diseases and many acupoints controlling one viscus" and clarify that nucleus of the solitary tract(NTS) may be an important primary nervous center in the medulla oblongata of "Neiguan" and "Zusanli" acupoints regulating cardiac and gastric functions,differences between acupuncture at "Neiguan" and "Zusanli" acupoints on neuronal discharges and c-fos expression in the NTS,and gastric pressure,as well as STⅡof electrocardiogram were observed in the normal and model rats.
Method:Effects of acupuncture at "Neiguan" and "Zusanli" acupoints on discharges of neurons in the NTS sensitive or not sensitive to gastric distension or arrhythmia and on c-fos expression in the NTS in gastric distension and myocardial ischemia rats were respectively observed by extracellular recording and immunohistochemistry techniques.
Results:1.neurons in the NTS was mainly excitatory response after acupuncture at Zusanli,Neiguan,Pianli and Heyang acupoints,however, there was significant difference between Zusanii and Neiguan groups and Pianli and Heyang groups in the ratio of appearance of those excitatory neurons(P＜0.01).Furthermore,discharge frequency of those excitatory neurons in four groups after acupuncture was higher than that before acupuncture(P＜0.01),showing that acupuncture has an obvious activation on neurons in the NTS.The percentage changes of the frequency of excitatory neurons in Zusanli and Neiguan groups were also obvious higher than those in Pianli and Heyang groups(P＜0.01).
2.①In 149 neurons in the NTS,65 neurons were responsive to gastric distension,in which 44 neurons were excited and 21 neurons were inhibited to the stimulation,showing neurons in the NTS were mainly excited to gastric distension.After acupuncture at Zusanli,Neiguan, Pianli and Heyang acupoints,those excitatory neurons mentioned above were inhibited,moreover,the ratio of inhibitory neurons in the Zusanli and Neiguan groups was obvious higher than that in the Pianli and Heyang groups(P＜0.01,P＜0.05).Acupuncture at Zusanli,Neiguan, Pianli and Heyang acupoints all produced remarkable decreases in discharge ratio of excitatory neurons in rats induced by gastric distension (P＜0.01),furthermore,the percentage changes of the frequency in the Zusanli and Neiguan groups were noticeably higher than those in the Pianli and Heyang groups(P＜0.01).
②In 116 neurons in the NTS,54 neurons were responsive to arrhythmia, in which 46 neurons were inhibited and 8 neurons were excited to the stimulation,showing that neurons in the NTS were mainly inhibited to arrhythmia.After acupuncture at Zusanli,Neiguan,Pianli and Heyang acupoints,those inhibitory neurons mentioned above were excited, moreover,the ratio of excitatory neurons in the Neiguan groups was obvious higher than that in the Pianli and Heyang groups(P＜0.05). Acupuncture at Zusanli,Neiguan,Pianli and Heyang acupoints all produced remarkable increases in discharge ratio of inhibitory neurons in rats induced by arrhythmia(P＜0.01),furthermore,the percentage changes of the frequency in the Zusanli and Neiguan groups were noticeably higher than those in the Pianli and Heyang groups(P＜0.01).
3.①The number of fos-immunoreactive(fos-IR) neurons in the NTS in Zusanli and Neiguan groups was significantly lower than that in the gastric distension group(P＜0.01) and obviously higher than that in Pianli and Heyang groups(P＜0.01).②A similar phenomenon was observed in the arrhythmia rats.The number of fos-immunoreactive(fos-IR) neurons in the NTS in Zusanli and Neiguan groups was significantly lower than that in the arrhythmia group(P＜0.01) and obviously higher than that in Pianli and Heyang groups(P＜0.01).
4.②Acupuncture at Zusanli and Neiguan acupoints increased significantly gastric pressure(P＜0.01),which was obviously higher than that after acupuncture at Pianli and Heyang acupoints(P＜0.01).②In the myocardial ischemia rats,acupuncture at Zusanli and Neiguan acupoints decreased significantly the value of STⅡof myocardiogram(P＜0.01), which was more obvious than that after acupuncture at Pianli and Heyang acupoints(P＜0.01).
Conclusion:1.Somatic afferent information induced by acupuncture at Neiguan and Zusanli acuponts and noxious visceral stimuli from the heart and stomach may converge in the NTS.2.NTS may be one of integrated nervous center of Neiguan and Zusanli acuponts in together regulating both the cardiac and gastric functions.3."One meridian or acupoint controlling many diseases and many acupoints controlling one viscus" is relative specificity.
方法:运用细胞外记录神经电生理学方法,研究针刺内关、足三里等穴对NTS神经元放电及对NTS胃扩张或心律失常敏感神经元放电的影响。运用免疫组织化学技术观察电针内关、足三里等穴对胃扩张或心肌缺血模型大鼠NTS内c-fos表达的影响。
结果:1、针刺足三里、内关、偏历、合阳穴各组,NTS内神经元主要以呈兴奋性反应为主。针刺足三里、内关穴组,NTS内兴奋性神经元出现率与针刺偏历、合阳穴组比较有显著性差异(P＜0.01)。选取对针刺腧穴呈兴奋性反应的NTS神经元,比较针刺前后神经元放电频率变化。针刺足三里、内关、偏历、合阳穴组,其针刺后放电频率均显著高于针刺前(P＜0.01),表明针刺对NTS神经元有明显的激活作用;针刺足三里穴组、内关穴组兴奋性神经元频率变化率显著高于针刺偏历、合阳穴组(P＜0.01)。
2、①149个NTS神经元中对胃扩张刺激起反应的有65个,其中44个神经元(44/65)被胃扩张刺激所兴奋,21个神经元(21/65)被胃扩张刺激所抑制,NTS神经元对胃扩张刺激以呈兴奋性反应为主。针刺足三里、内夭、偏历、合阳穴各组,NTS胃扩张兴奋性神经元主要呈抑制性反应。针刺足三里、内关穴组,NTS胃扩张兴奋性神经元呈抑制反应的出现率显著高于针刺偏历、合阳穴组(P＜0.01或P＜0.05)。针刺足三里、内关、偏历、合阳穴组,均可使胃扩张模型大鼠NTS兴奋性神经元放电频率显著降低(P＜0.01)。针刺足三里、肉关穴组NTS胃扩张兴奋性神经元频率变化率显著高于针刺偏历、合阳穴组(P＜0.01)。
②116个NTS神经元中对心律失常刺激起反应的有54个,其中46个神经元(46/54)被心律失常刺激所抑制,8个神经元(8/54)被心律失常刺激所兴奋。NTS神经元对乌头碱造成心律失常刺激以呈抑制性反应为主。针刺足三里、内关、偏历、合阳穴各组,NTS心律失常抑制性神经元主要呈兴奋性反应。针刺内关穴组,NTS心律失常抑制性神经元呈兴奋反应的出现率显著高于针刺偏历、合阳穴组(P＜0.05)。针刺足三里、内关、偏历、合阳穴组,均可使心律失常模型大鼠NTS抑制性神经元放电频率显著增加(P＜0.01)。针刺足三里、内关穴组NTS心律失常抑制性神经元频率变化率显著高于针刺偏历、合阳穴组(P＜0.01)。
3、①造成大鼠胃扩张模型后,能显著诱导NTS内c-fos的表达;电针足三里、内关穴组与胃扩张模型组比较,NTS内Fos阳性细胞数均有显著性降低(P＜0.01);电针足三里、内关穴组NTS内Fos阳性细胞数显著低于电针偏历、合阳穴组(P＜0.01)。②造成大鼠心肌缺血模型后,能显著诱导NTS内c-fos的表达;电针足三里、内关穴组与心肌缺血模型组比较,NTS内Fos阳性细胞数均有显著性降低(P＜0.01);电针足三里、内关穴组NTS内Fos阳性细胞数显著低于电针偏历、合阳穴组(P＜0.01)。
4、①电针足三里、内关穴组能显著升高胃扩张模型大鼠胃内压(P＜0.01),其胃内压升高程度高于电针偏历、合阳穴组(P＜0.01)。②电针足三里、内关穴组能显著降低心肌缺血模型大鼠ST_Ⅱ电位值(P＜0.01),其电位降低值大于电针偏历、合阳穴组(P＜0.01)。
结论:1、针刺内关、足三里穴区的躯体感觉传入和心胃的内脏伤害性刺激传入在NTS发生汇聚。2、NTS是针刺内关、足三里穴共同调节心胃功能的整合中枢之一。3、多病症一经(穴)司控,一脏(腑)多经(穴)调控具有相对的特异性。
Objective:To explore the mechanism of "one meridian or acupoint controlling many diseases and many acupoints controlling one viscus" and clarify that nucleus of the solitary tract(NTS) may be an important primary nervous center in the medulla oblongata of "Neiguan" and "Zusanli" acupoints regulating cardiac and gastric functions,differences between acupuncture at "Neiguan" and "Zusanli" acupoints on neuronal discharges and c-fos expression in the NTS,and gastric pressure,as well as STⅡof electrocardiogram were observed in the normal and model rats.
Method:Effects of acupuncture at "Neiguan" and "Zusanli" acupoints on discharges of neurons in the NTS sensitive or not sensitive to gastric distension or arrhythmia and on c-fos expression in the NTS in gastric distension and myocardial ischemia rats were respectively observed by extracellular recording and immunohistochemistry techniques.
Results:1.neurons in the NTS was mainly excitatory response after acupuncture at Zusanli,Neiguan,Pianli and Heyang acupoints,however, there was significant difference between Zusanii and Neiguan groups and Pianli and Heyang groups in the ratio of appearance of those excitatory neurons(P＜0.01).Furthermore,discharge frequency of those excitatory neurons in four groups after acupuncture was higher than that before acupuncture(P＜0.01),showing that acupuncture has an obvious activation on neurons in the NTS.The percentage changes of the frequency of excitatory neurons in Zusanli and Neiguan groups were also obvious higher than those in Pianli and Heyang groups(P＜0.01).
2.①In 149 neurons in the NTS,65 neurons were responsive to gastric distension,in which 44 neurons were excited and 21 neurons were inhibited to the stimulation,showing neurons in the NTS were mainly excited to gastric distension.After acupuncture at Zusanli,Neiguan, Pianli and Heyang acupoints,those excitatory neurons mentioned above were inhibited,moreover,the ratio of inhibitory neurons in the Zusanli and Neiguan groups was obvious higher than that in the Pianli and Heyang groups(P＜0.01,P＜0.05).Acupuncture at Zusanli,Neiguan, Pianli and Heyang acupoints all produced remarkable decreases in discharge ratio of excitatory neurons in rats induced by gastric distension (P＜0.01),furthermore,the percentage changes of the frequency in the Zusanli and Neiguan groups were noticeably higher than those in the Pianli and Heyang groups(P＜0.01).
②In 116 neurons in the NTS,54 neurons were responsive to arrhythmia, in which 46 neurons were inhibited and 8 neurons were excited to the stimulation,showing that neurons in the NTS were mainly inhibited to arrhythmia.After acupuncture at Zusanli,Neiguan,Pianli and Heyang acupoints,those inhibitory neurons mentioned above were excited, moreover,the ratio of excitatory neurons in the Neiguan groups was obvious higher than that in the Pianli and Heyang groups(P＜0.05). Acupuncture at Zusanli,Neiguan,Pianli and Heyang acupoints all produced remarkable increases in discharge ratio of inhibitory neurons in rats induced by arrhythmia(P＜0.01),furthermore,the percentage changes of the frequency in the Zusanli and Neiguan groups were noticeably higher than those in the Pianli and Heyang groups(P＜0.01).
3.①The number of fos-immunoreactive(fos-IR) neurons in the NTS in Zusanli and Neiguan groups was significantly lower than that in the gastric distension group(P＜0.01) and obviously higher than that in Pianli and Heyang groups(P＜0.01).②A similar phenomenon was observed in the arrhythmia rats.The number of fos-immunoreactive(fos-IR) neurons in the NTS in Zusanli and Neiguan groups was significantly lower than that in the arrhythmia group(P＜0.01) and obviously higher than that in Pianli and Heyang groups(P＜0.01).
4.②Acupuncture at Zusanli and Neiguan acupoints increased significantly gastric pressure(P＜0.01),which was obviously higher than that after acupuncture at Pianli and Heyang acupoints(P＜0.01).②In the myocardial ischemia rats,acupuncture at Zusanli and Neiguan acupoints decreased significantly the value of STⅡof myocardiogram(P＜0.01), which was more obvious than that after acupuncture at Pianli and Heyang acupoints(P＜0.01).
Conclusion:1.Somatic afferent information induced by acupuncture at Neiguan and Zusanli acuponts and noxious visceral stimuli from the heart and stomach may converge in the NTS.2.NTS may be one of integrated nervous center of Neiguan and Zusanli acuponts in together regulating both the cardiac and gastric functions.3."One meridian or acupoint controlling many diseases and many acupoints controlling one viscus" is relative specificity.
引文
【1]朱兵.针灸的科学基础.青岛:青岛出版社,1998,326-339
[2]Paxions G and Watson C.The rat brain in stereotaxic coordinate.London:Academic Press,1982
[3]Sternfeld M,Shalev Y,Eliraz A,et al.Effect of acupuncture on symptomatology and objective cardiac parameters in angina pectois.Am.J.acupuncture,1987,15:149-152
【4]余礼,王天佑.针刺内关治疗冠心病98例.山东中医杂志,1999,18(7):213-214
【5】 胡乃珂.针刺内关穴治疗冠心病心绞痛血液流变学观察.山东中医杂志,1997,16(3):116-119
[6】 唐家槐,陈玉珍.针刺内关引起幽门运动的观察.中国针灸,1997,(11):655-656
[7】 吴亚丽,李宇权,陈少夫.电针内关对胃酸分泌、血清胃泌素、血浆生长抑素及胃动素的影响.中国医科大学学报,1995,24(1):63-65
[8】 常小荣,严洁,林亚平,等.胃病患者针刺前后胃运动及胃体表投影区温度的变化.中国医学丈摘内科学分册英文版专刊,1996,35-36
[9]常小荣,严洁,林亚平,等.针刺足阳明经穴对FD病人胃运动总功率的影响.中国中医药信息杂志,2001,10(3):72-73
[10]林亚平,钱立伟,刘凌宇,等.留针在针刺调节幽门括约肌压力过程中作用的观察.湖南中医药导报,1997,3(2-3):60-61
【11】郑关毅,陈晓东,韦立新.针刺对冠心病患者血浆内皮素的影响.上海针灸杂志,1999,18(1):6-7
【12]杨洪军,苏勋庄.电针合用地奥心血康治疗心肌缺血性头痛.河南中医,2001,21(4):56-59
【13】 石学敏,针灸学.北京:中国中医药出版社,2003,235-245
【14】 严洁,常小荣,李克玲,等.针刺足阳明不同部位腧穴对人体胃窦容积变化的动态观察.针刺研究,1995,20(1):60-61
【15]严洁,常小荣,黄必群,等.针剌足阳明胃经不同穴点对胃窦面积影响的结果分析.中国针灸,1999,19(3):167-168
[16]常小荣,严洁,易受乡,等.针刺足阳明经四白、内庭对胃蠕动功能的影响.中医杂志,1999,40(4):217-218
[17] 常小荣,严洁,易受乡,等.针刺足阳明经穴对健康人血浆胃动素、胃泌素含量的影响.中国中医药科技,2001,8(1):25-29
[18]严洁,常小荣,刘健华,等.电针足阳明经穴对家兔胃粘膜损伤防御性保护作用的研究.中国针灸,2001,21(6):350-352
[19] 朱江,王美卿,张露芬,等.电针晚孕大鼠合谷、三阴交穴对子宫收缩活动的影响.北京中医药大学学报,2003,26(2):73-75
[20]郭继龙,李妍.合谷穴自体血封闭对哮喘大鼠气道平滑肌增生及c-fos表达的影响.中医外治杂志,2004,13(3):54-55
[21]李学惠.内关、神门、心俞间协同作用与拮抗作用实验研究.中国针灸,2002,22(12):819-821
[22] 曹庆淑,王淑玲,刘俊岭.电针对家兔急性心肌缺血性损伤的影响.中医杂志,1981,(22):307-308
[23]黄晓卿,姚志方,陈凌,等.胃经和心包经穴位对多器官功能调节的实验观察.中国针灸,2004,24(2):134-136
[24]刘瑞庭,庄鼎,杨秀珍,等.循经感传现象客观显示的研究—上肢经脉循行部位红外热像图的变化.针刺研究,1990,15(3):239-243
[25] 刘瑞庭,庄鼎,杨秀珍,等.循经感传“气至病所”的客观显示—针刺穴位对面部红外热像图的影响.针刺研究,1990,15(3):245-246
[26]李桂兰,王秀云,郭义,等.针刺镇痛的外周经穴特异性研究.中国中医药科技,1995,2(5):9-10
[27] 张建梁,晋志高,逯波,等.脊髓背角神经元对胃扩张及电针足三里穴的反应.针刺研究,2001,26(4):268-273
[28]Cervero F.Afferent activity evoked by natural stimulation of the biliary system in the ferret.Pain,1982,13:137-151
[29]Cervero F.Somatic and visceral inputs to the thoracic spinal cord of the cat:effects of noxious stimulation of the biliary system.J.Phys -iol,1983,337:51-67
[30]Cervero F.Supraspinal connections of neurons in the thoracic spinal cord of the cat:Ascending projections and effects of descending impulses.Brain Res,1983,275:251-261
[31]KaliaM,Fuxek,Hokfeltt,et al.Distribution of neuropeptide immunoreactive nerve terminal swith in the subnuclei of the nucleus of the tractus solitarius of the rat.J Comp Neuro,1984,222(3):409-444
[32]Kalia M,Mesulam MM.Brain stem projection of sensory and motor components of the vagus complex in the cat:the cervical vagus and nodose ganglion.J Comp Neurol,1980,193:453-465
[33]Diz DI,Barnes KL,Ferrario CM.Functional characteristics of neuropeptides in the dorsal medulla oblongata and vagus nerve.Feder -ationProc,1987,46:30-35
[34]Leslie RA.Neuroactive substance in the dorsal vagal complex of the medulla oblongata:neucleus of the tractus solitarius area postrema and dorsal motor nucleus of the vegus.Neurochem Int,1985,7:191-212
[35]Mifflin SW,Felder RB.Synaptic mechanisms regulating cardiovascular afferent inputs to solitary tract nucleus.Am J Physiol,1990,259:H653-661
[36]Onai T,Sajim,Miura M.Functional subdivisions of the nucleus tractus solitarii of the rat as determined by circulatory and respiratory responses to electrical stimulation of the nucleus.J Auton Nerve Syst,1987,21:195- 202
[37]Traub RJ,Sengupta JN,Gebhart GF.Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat.Neuroscience,1996,74(3):873-884
【38]易春霞,茹立强,胡道松.迷走神经参与胃伤害性信息向下丘脑的传递.中国神经科学杂志,2004,20(5):353-356
[39]Berk ML,Smith SE.Local and commissural neuropeptide -containing projections of the nucleus of the solitary tract to the dorsal vagal complex in the pigeon.J Comp Neurol,1994,15;347(3):369-396
[40]Ladic LA,Buchan AM.Association of substance P and its receptor with efferent neurons projecting to the greater curvature of the rat stomach.J Auton Nerv Syst, 1996,20;58(1-2):25-34
[41]Fujimiya M,Inui A.Peptidergic regulation of gastrointestinal motility in rodents.Peptides,2000,21:1565-1582
[42]Rinaman L,Card JP,Schwaber JS,et al.Ultrastructureal demonstration of a gastric monosynaptie vagal circuit in the nucleus of the solitary tract in rat.J neurosci,1989,9:1985-1996
[43]Higgins GA.Hoffman GE,Wray S,et al.Distribution of neurotension-immunoreactivity within barorecerptive portions of the nucleus of the tractus solotarius and the dorsal vagal nucleus of the rat.J Comp Neurol,1984,226:155-164
[44]Rinaman L,Card JP,Schwaber JS,Miselis RR.Ultrastructural demonstration of a gastric monosynaptic vagal circuit in the nucleus of the solitary tract in rat.J Neurosci,1989,9(6):1985-1996
[45]Zhang X,Renehan WE,Fogel R.Neurons in the vagal complex of the rat respond to mechanical and chemical stimulation of the GI tract.Am J Physiol,1998,274(2Ptl):331-341
[46]McCann MJ,Rogers RC.Impact of antral mechanoreceptor activation on the vago-vagal reflex in the rat:functional zonation of responses.J Physiol,1992,453:401-411
[47]Massari VJ,Shirahata M,Johnson TA,et al.Substance P mmuno -reactive nerve terminals in the dorsolateral nucleus of the tractus solitarius:roles in the baroreceptor reflex.Brain Res,1998,785(2):329-340
[48]Lan CT,Wu WC,Ling EA,et al.Evidence of a direct projection from the cardiovascular reactive dorsal medulla to the intermedio -lateral cell column of the spinal cord in cats revealed by light and electron microscopy.Neuroscience,1997,77:521-533
【49]李振中,于彦铮.沿迷走神经传入的心脏感觉纤维在豚鼠左心房的分布.解剖学杂志,1998,21(2):102-104
[50]Guyenet PG,Filtz TM,Donaldson SR,et al.Role of excitatory amino acids in rat vagal and sympathetic baroreflexes.Brain Res,1987,407:272- 284
[51]Singewald N,Philippu A,Involvement of biogenicamines and amino acids in the central regulation of cardiovascular homeostasis.Tips,1996,17:356-363.
【52】 何瑞荣,卢振东.心血管生理学.北京:人民卫生出版社,1987,134-159
【53】 王景杰,黄裕新,王键,等.c-fos在电针调控大鼠胃运动中的表达及意义针刺研究.200l,26(4):274-278
【54]张进,陈东风,李依为,等.电针内关穴诱导大鼠延髓原癌基因c-fos表达.广州中医药大学学报,2001,18(2):134-136
【55]黄裕新,王景杰,王晓斌,等.胃经穴位电针调节胃运动的神经作用机制.胃肠病学和肝病学杂志,2004,13(4):358-362
[56】 曹庆淑,刘俊岭,庄鼎,等.内关-心脏相关及孤束核的调控作用.中国医药学报,1993,8(4):20-22
【57】 席时元,陶之理.“足三里”穴传入途径的探讨.针刺研究,1982,7:66-69
[58]Loewy AD,Burton H.Nuclei of the solitary tract:efferent pro -jections to the lower brain stem and spinal cord of the cat.J Comp Neurol,1978,181:421- 430
【59】 孟卓,吕国蔚.大鼠脊髓背角神经元与孤束核的电生理研究.科学通报,1990,4:292-295
【60】 孟卓,吕国蔚.足三里-脊髓背角-孤束核的功能联系.中国科学,1992,35:393-399
【61】 孟卓,陶之理.大鼠脊髓灰质向孤束核的投射.神经解剖学杂志.1986,2(1):141-143
【62]吴利平,李辉,李云庆.大鼠延髓和脊髓背角的PKCr阳性神经元向弧束核投射.第四军医大学学报,2001,22(23):2171-2174
[63]Lullian WE.Patter and time course of immediate early gene expression in rat brain following acute stress.Neurosci,1995,64:477-483
[64]Honkamiemi T.Induction of multiple immediate early genein rat hypothalamic paraventricular nucleus after stress.Molecular Brain Research,1994,25:234-241
【65】 王曦,王百忍,段晓莉.正常生活状态下的大鼠脑中Fos的基础表达.神经解剖学杂志,2000,16(4):353-358
【66]杨志军,饶志仁,邱建勇,等.膈下迷走神经切断术抑制腹腔给予LPS诱导的延髓内脏带内Fos表达.解剖学报,2000,31(2):97-102
[67]Rauscher FJ,Sam bucetti LC,Curran T,et al.Common DNA binding site for fos protein complexes and transcription factor AP-1.Cell,1988,52(3):471-488
【68]张进,陈东风,李依为,等.电针内关穴诱导大鼠延髓原癌基因c-fos表达.广州中医药大学学报,2001,18(2):134-136
【69】 王景杰,黄裕新,王键等.c-fos在电针调控大鼠胃运动中的表达及意义.针刺研究,200l,26(4):274-278
【70】 管振龙,郎兵,丁玉强.胃畅道伤害性刺激引起大鼠孤束核与中脑导水管周围灰质神经元表达FOS.Chin J Neuorosci,1998,Vol14(4):199-204
【71]陈良为,饶志仁,施际武.内脏伤害性刺激诱导的大鼠延髓内Fos表达.解剖学报,1995,26(2):127-131
【72】 高文,饶志仁.心血管应急大鼠延髓内脏带神经元Fos蛋白表达.第四军医大学学报,1998,19(4):377-341
【73】 董元祥,熊抗辉,饶志仁.大鼠孤柬核和延髓腹外侧区至下丘脑外侧区的儿茶酚胺能投射神经元在胃伤害性刺激后的Fos表达.神经解剖学杂志,1995,11(4):363-367
【74】 阮怀珍,李希成,黎海蒂,等.生长抑素和电针抑制关节炎大鼠脊髓c-fos 的表达[J].针刺研究,1997,22(1,2):62-63
【75]范斌,笪翠娣,周敬修.伤害性刺激及电针时大鼠脊髓中前脑啡肽原与FOS 蛋白的表达[J】.上海医科大学学报,1997,24(6):461-464.
【76】 方智慧,黄大鹏,王金兰,等.针刺镇痛时下橄榄核FOS蛋白的表达【J】.河南医科大学学报,1995,(3):221-224.
【77】 易春霞,茹立强,胡道松.电针抗胃炎性痛对内脏感觉c-fos及NOS阳性神经元的吴影响.针刺研究,2004,29(1):24-30
1 张庆宏,周福生.析“心胃相关”.云南中医学院学报,2001,24(2):39
2 周福生,程宏辉,祝淑贞.心胃相关理论的临床应用.云南中医学院学报,2003,26(4):10-11
3 张泽灵.编著.心脏内科主治医师400问.第2版.北京:中国协和医科大学出版社,2000:395
4 郝悦,黄裕新,王景杰.心理性应激对大鼠胃排空的影响及胃粘膜的损伤[J].第四军医大学学报,2002,23(7):603-605
5 Tsukada F,Sawamura K,Kohno H.Mechanism of inhibition of small intestinal motility by restraint stress difers from that with norepinephfine treatment in rats[J].Biol Pharm Bull,2002,25(1):122-126
6 Muelas MS,Ramirez P,Parrilla P.Vagal system involvement in changes in smali bowel motility during restraint stress:an experimental study in the dog[J].BT J Surg,1993,80(4):479-483
7 Diz DI,Barnes KL,Ferrario CM.Functional characteristics of neuropeptides in the dorsal medulla oblongata and vagus nerve.Federation Proc.1987,46:30-35
8 Leslie RA.Neuroactive substance in the dorsal vagal complex of the medulla oblongata:neucleus of the tractus solitarius area postrema,and dorsal motor nucleus of the vegus.Neurochem Int.1985,7:191-212
9 Mifflin SW,Felder RB.Synaptic mechanisms regulating cardiovascular afferent inputs,to solitary tract nucleus.Am J Physiol.1990,259:H653-661
10 Onai T,Sajim,Miura M.Functional subdivisions of the nucleus tractus solitarii of the rat as determined by circulatory and respiratory responses to electrical stimulation of the nucleus.J Auton Nerve Syst.1987,21:195-202
11 Kalia M,Fuxek,Hokfeltt,et al.Distribution of neuropeptide immunoreactive nerve terminal swith in the subnuclei of the nucleus of the tractus solitarius of the rat.J Comp Neuro,1984,222(3):409,444
12 Kalia M,Mesulam MM.Brain stem projection of sensory and motor components of the vagus complex in the cat:the cervical vagus and nodose ganglion.J Comp Neurol,1980,193:453-465
13 程世斌,罗天锡,卢光启.迷走神经背核内胃副交感节前神经元的超微结构 及联系.神经解剖学杂志,1992,8:225-229
14 Berk ML.Projections of the lateral hypothalamus and bed nucleus of the stria terminalis to the dorsal vagal complex in the pigeon.J Comp Neurol,1987,260:140-156
15 Gray TS,Magnuso DJ.Neuropeptide neuronal efferents from the bed nucleus of the stria terminalis and central amgydaloid nucleus to the dorsal vagal complex in the rat.J Comp Neurol.1987,262:365-374
16 Rinaman L,Card JP,Schwaber JS,et al.Ult(?)astructureal demonstration of a gastric monosynaptie vagal circuit in the nucleus of the solitary tract in rat.J neurosci.1989;9:1985-1996
17 Higgins GA,Hoffman GE,Wray S,et al.Distribution of neurotension-immunoreactivity within barorecerptive portions of the nucleus of the tractus solotarius and the dorsal vagal nucleus of the rat.J Comp Neurol.1984;226:155-164
18 Traub RJ,Sengupta JN,Gebhart GF.Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat.Neuroscience,1996,74(3):873-884
19 易春霞,茹立强,胡道松.迷走神经参与胃伤害性信息向下丘脑的传递.中国神经科学杂志,2004,20(5):353-356
20 Shapiro RE,Miselis RR.The centrao orgnization fo the vagus nerve innervationg the stomach of the rat.J Comp Neural.1985;238:473-488
21 Massari VJ,Shirahata M,Johnson TA,et al.Substance P mmuno -reactive nerve terminals in the dorsolateral nucleus of the tractus solitarius:roles in the baroreceptorreflex.Brain Res,1998,785(2):329-340
22 Lan CT,Wu WC,Ling EA,et al.Evidence of a direct projection from the cardiovascular reactive dorsal medulla to the intermedio -lateral cell column of the spinal cord in cats revealed by light and electron microscopy.Neuroscience,1997,77:521- 533
23 李振中,于彦铮.沿迷走神经传入的心脏感觉纤维在豚鼠左心房的分布.解剖学杂志,1998,21(2):102-104
24 陈良为,饶志仁,施际武.内脏伤害性刺激诱导的大鼠延髓内FOS表达【J].解剖学报,1995,26(2):127
25 Paton JF, Kasparov S. Sensory channel specific modulation in the nucleus of the solitary tract. J Auton Nerv Syst. 80 (2000): 117-129
[2]Paxions G and Watson C.The rat brain in stereotaxic coordinate.London:Academic Press,1982
[3]Sternfeld M,Shalev Y,Eliraz A,et al.Effect of acupuncture on symptomatology and objective cardiac parameters in angina pectois.Am.J.acupuncture,1987,15:149-152
【4]余礼,王天佑.针刺内关治疗冠心病98例.山东中医杂志,1999,18(7):213-214
【5】 胡乃珂.针刺内关穴治疗冠心病心绞痛血液流变学观察.山东中医杂志,1997,16(3):116-119
[6】 唐家槐,陈玉珍.针刺内关引起幽门运动的观察.中国针灸,1997,(11):655-656
[7】 吴亚丽,李宇权,陈少夫.电针内关对胃酸分泌、血清胃泌素、血浆生长抑素及胃动素的影响.中国医科大学学报,1995,24(1):63-65
[8】 常小荣,严洁,林亚平,等.胃病患者针刺前后胃运动及胃体表投影区温度的变化.中国医学丈摘内科学分册英文版专刊,1996,35-36
[9]常小荣,严洁,林亚平,等.针刺足阳明经穴对FD病人胃运动总功率的影响.中国中医药信息杂志,2001,10(3):72-73
[10]林亚平,钱立伟,刘凌宇,等.留针在针刺调节幽门括约肌压力过程中作用的观察.湖南中医药导报,1997,3(2-3):60-61
【11】郑关毅,陈晓东,韦立新.针刺对冠心病患者血浆内皮素的影响.上海针灸杂志,1999,18(1):6-7
【12]杨洪军,苏勋庄.电针合用地奥心血康治疗心肌缺血性头痛.河南中医,2001,21(4):56-59
【13】 石学敏,针灸学.北京:中国中医药出版社,2003,235-245
【14】 严洁,常小荣,李克玲,等.针刺足阳明不同部位腧穴对人体胃窦容积变化的动态观察.针刺研究,1995,20(1):60-61
【15]严洁,常小荣,黄必群,等.针剌足阳明胃经不同穴点对胃窦面积影响的结果分析.中国针灸,1999,19(3):167-168
[16]常小荣,严洁,易受乡,等.针刺足阳明经四白、内庭对胃蠕动功能的影响.中医杂志,1999,40(4):217-218
[17] 常小荣,严洁,易受乡,等.针刺足阳明经穴对健康人血浆胃动素、胃泌素含量的影响.中国中医药科技,2001,8(1):25-29
[18]严洁,常小荣,刘健华,等.电针足阳明经穴对家兔胃粘膜损伤防御性保护作用的研究.中国针灸,2001,21(6):350-352
[19] 朱江,王美卿,张露芬,等.电针晚孕大鼠合谷、三阴交穴对子宫收缩活动的影响.北京中医药大学学报,2003,26(2):73-75
[20]郭继龙,李妍.合谷穴自体血封闭对哮喘大鼠气道平滑肌增生及c-fos表达的影响.中医外治杂志,2004,13(3):54-55
[21]李学惠.内关、神门、心俞间协同作用与拮抗作用实验研究.中国针灸,2002,22(12):819-821
[22] 曹庆淑,王淑玲,刘俊岭.电针对家兔急性心肌缺血性损伤的影响.中医杂志,1981,(22):307-308
[23]黄晓卿,姚志方,陈凌,等.胃经和心包经穴位对多器官功能调节的实验观察.中国针灸,2004,24(2):134-136
[24]刘瑞庭,庄鼎,杨秀珍,等.循经感传现象客观显示的研究—上肢经脉循行部位红外热像图的变化.针刺研究,1990,15(3):239-243
[25] 刘瑞庭,庄鼎,杨秀珍,等.循经感传“气至病所”的客观显示—针刺穴位对面部红外热像图的影响.针刺研究,1990,15(3):245-246
[26]李桂兰,王秀云,郭义,等.针刺镇痛的外周经穴特异性研究.中国中医药科技,1995,2(5):9-10
[27] 张建梁,晋志高,逯波,等.脊髓背角神经元对胃扩张及电针足三里穴的反应.针刺研究,2001,26(4):268-273
[28]Cervero F.Afferent activity evoked by natural stimulation of the biliary system in the ferret.Pain,1982,13:137-151
[29]Cervero F.Somatic and visceral inputs to the thoracic spinal cord of the cat:effects of noxious stimulation of the biliary system.J.Phys -iol,1983,337:51-67
[30]Cervero F.Supraspinal connections of neurons in the thoracic spinal cord of the cat:Ascending projections and effects of descending impulses.Brain Res,1983,275:251-261
[31]KaliaM,Fuxek,Hokfeltt,et al.Distribution of neuropeptide immunoreactive nerve terminal swith in the subnuclei of the nucleus of the tractus solitarius of the rat.J Comp Neuro,1984,222(3):409-444
[32]Kalia M,Mesulam MM.Brain stem projection of sensory and motor components of the vagus complex in the cat:the cervical vagus and nodose ganglion.J Comp Neurol,1980,193:453-465
[33]Diz DI,Barnes KL,Ferrario CM.Functional characteristics of neuropeptides in the dorsal medulla oblongata and vagus nerve.Feder -ationProc,1987,46:30-35
[34]Leslie RA.Neuroactive substance in the dorsal vagal complex of the medulla oblongata:neucleus of the tractus solitarius area postrema and dorsal motor nucleus of the vegus.Neurochem Int,1985,7:191-212
[35]Mifflin SW,Felder RB.Synaptic mechanisms regulating cardiovascular afferent inputs to solitary tract nucleus.Am J Physiol,1990,259:H653-661
[36]Onai T,Sajim,Miura M.Functional subdivisions of the nucleus tractus solitarii of the rat as determined by circulatory and respiratory responses to electrical stimulation of the nucleus.J Auton Nerve Syst,1987,21:195- 202
[37]Traub RJ,Sengupta JN,Gebhart GF.Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat.Neuroscience,1996,74(3):873-884
【38]易春霞,茹立强,胡道松.迷走神经参与胃伤害性信息向下丘脑的传递.中国神经科学杂志,2004,20(5):353-356
[39]Berk ML,Smith SE.Local and commissural neuropeptide -containing projections of the nucleus of the solitary tract to the dorsal vagal complex in the pigeon.J Comp Neurol,1994,15;347(3):369-396
[40]Ladic LA,Buchan AM.Association of substance P and its receptor with efferent neurons projecting to the greater curvature of the rat stomach.J Auton Nerv Syst, 1996,20;58(1-2):25-34
[41]Fujimiya M,Inui A.Peptidergic regulation of gastrointestinal motility in rodents.Peptides,2000,21:1565-1582
[42]Rinaman L,Card JP,Schwaber JS,et al.Ultrastructureal demonstration of a gastric monosynaptie vagal circuit in the nucleus of the solitary tract in rat.J neurosci,1989,9:1985-1996
[43]Higgins GA.Hoffman GE,Wray S,et al.Distribution of neurotension-immunoreactivity within barorecerptive portions of the nucleus of the tractus solotarius and the dorsal vagal nucleus of the rat.J Comp Neurol,1984,226:155-164
[44]Rinaman L,Card JP,Schwaber JS,Miselis RR.Ultrastructural demonstration of a gastric monosynaptic vagal circuit in the nucleus of the solitary tract in rat.J Neurosci,1989,9(6):1985-1996
[45]Zhang X,Renehan WE,Fogel R.Neurons in the vagal complex of the rat respond to mechanical and chemical stimulation of the GI tract.Am J Physiol,1998,274(2Ptl):331-341
[46]McCann MJ,Rogers RC.Impact of antral mechanoreceptor activation on the vago-vagal reflex in the rat:functional zonation of responses.J Physiol,1992,453:401-411
[47]Massari VJ,Shirahata M,Johnson TA,et al.Substance P mmuno -reactive nerve terminals in the dorsolateral nucleus of the tractus solitarius:roles in the baroreceptor reflex.Brain Res,1998,785(2):329-340
[48]Lan CT,Wu WC,Ling EA,et al.Evidence of a direct projection from the cardiovascular reactive dorsal medulla to the intermedio -lateral cell column of the spinal cord in cats revealed by light and electron microscopy.Neuroscience,1997,77:521-533
【49]李振中,于彦铮.沿迷走神经传入的心脏感觉纤维在豚鼠左心房的分布.解剖学杂志,1998,21(2):102-104
[50]Guyenet PG,Filtz TM,Donaldson SR,et al.Role of excitatory amino acids in rat vagal and sympathetic baroreflexes.Brain Res,1987,407:272- 284
[51]Singewald N,Philippu A,Involvement of biogenicamines and amino acids in the central regulation of cardiovascular homeostasis.Tips,1996,17:356-363.
【52】 何瑞荣,卢振东.心血管生理学.北京:人民卫生出版社,1987,134-159
【53】 王景杰,黄裕新,王键,等.c-fos在电针调控大鼠胃运动中的表达及意义针刺研究.200l,26(4):274-278
【54]张进,陈东风,李依为,等.电针内关穴诱导大鼠延髓原癌基因c-fos表达.广州中医药大学学报,2001,18(2):134-136
【55]黄裕新,王景杰,王晓斌,等.胃经穴位电针调节胃运动的神经作用机制.胃肠病学和肝病学杂志,2004,13(4):358-362
[56】 曹庆淑,刘俊岭,庄鼎,等.内关-心脏相关及孤束核的调控作用.中国医药学报,1993,8(4):20-22
【57】 席时元,陶之理.“足三里”穴传入途径的探讨.针刺研究,1982,7:66-69
[58]Loewy AD,Burton H.Nuclei of the solitary tract:efferent pro -jections to the lower brain stem and spinal cord of the cat.J Comp Neurol,1978,181:421- 430
【59】 孟卓,吕国蔚.大鼠脊髓背角神经元与孤束核的电生理研究.科学通报,1990,4:292-295
【60】 孟卓,吕国蔚.足三里-脊髓背角-孤束核的功能联系.中国科学,1992,35:393-399
【61】 孟卓,陶之理.大鼠脊髓灰质向孤束核的投射.神经解剖学杂志.1986,2(1):141-143
【62]吴利平,李辉,李云庆.大鼠延髓和脊髓背角的PKCr阳性神经元向弧束核投射.第四军医大学学报,2001,22(23):2171-2174
[63]Lullian WE.Patter and time course of immediate early gene expression in rat brain following acute stress.Neurosci,1995,64:477-483
[64]Honkamiemi T.Induction of multiple immediate early genein rat hypothalamic paraventricular nucleus after stress.Molecular Brain Research,1994,25:234-241
【65】 王曦,王百忍,段晓莉.正常生活状态下的大鼠脑中Fos的基础表达.神经解剖学杂志,2000,16(4):353-358
【66]杨志军,饶志仁,邱建勇,等.膈下迷走神经切断术抑制腹腔给予LPS诱导的延髓内脏带内Fos表达.解剖学报,2000,31(2):97-102
[67]Rauscher FJ,Sam bucetti LC,Curran T,et al.Common DNA binding site for fos protein complexes and transcription factor AP-1.Cell,1988,52(3):471-488
【68]张进,陈东风,李依为,等.电针内关穴诱导大鼠延髓原癌基因c-fos表达.广州中医药大学学报,2001,18(2):134-136
【69】 王景杰,黄裕新,王键等.c-fos在电针调控大鼠胃运动中的表达及意义.针刺研究,200l,26(4):274-278
【70】 管振龙,郎兵,丁玉强.胃畅道伤害性刺激引起大鼠孤束核与中脑导水管周围灰质神经元表达FOS.Chin J Neuorosci,1998,Vol14(4):199-204
【71]陈良为,饶志仁,施际武.内脏伤害性刺激诱导的大鼠延髓内Fos表达.解剖学报,1995,26(2):127-131
【72】 高文,饶志仁.心血管应急大鼠延髓内脏带神经元Fos蛋白表达.第四军医大学学报,1998,19(4):377-341
【73】 董元祥,熊抗辉,饶志仁.大鼠孤柬核和延髓腹外侧区至下丘脑外侧区的儿茶酚胺能投射神经元在胃伤害性刺激后的Fos表达.神经解剖学杂志,1995,11(4):363-367
【74】 阮怀珍,李希成,黎海蒂,等.生长抑素和电针抑制关节炎大鼠脊髓c-fos 的表达[J].针刺研究,1997,22(1,2):62-63
【75]范斌,笪翠娣,周敬修.伤害性刺激及电针时大鼠脊髓中前脑啡肽原与FOS 蛋白的表达[J】.上海医科大学学报,1997,24(6):461-464.
【76】 方智慧,黄大鹏,王金兰,等.针刺镇痛时下橄榄核FOS蛋白的表达【J】.河南医科大学学报,1995,(3):221-224.
【77】 易春霞,茹立强,胡道松.电针抗胃炎性痛对内脏感觉c-fos及NOS阳性神经元的吴影响.针刺研究,2004,29(1):24-30
1 张庆宏,周福生.析“心胃相关”.云南中医学院学报,2001,24(2):39
2 周福生,程宏辉,祝淑贞.心胃相关理论的临床应用.云南中医学院学报,2003,26(4):10-11
3 张泽灵.编著.心脏内科主治医师400问.第2版.北京:中国协和医科大学出版社,2000:395
4 郝悦,黄裕新,王景杰.心理性应激对大鼠胃排空的影响及胃粘膜的损伤[J].第四军医大学学报,2002,23(7):603-605
5 Tsukada F,Sawamura K,Kohno H.Mechanism of inhibition of small intestinal motility by restraint stress difers from that with norepinephfine treatment in rats[J].Biol Pharm Bull,2002,25(1):122-126
6 Muelas MS,Ramirez P,Parrilla P.Vagal system involvement in changes in smali bowel motility during restraint stress:an experimental study in the dog[J].BT J Surg,1993,80(4):479-483
7 Diz DI,Barnes KL,Ferrario CM.Functional characteristics of neuropeptides in the dorsal medulla oblongata and vagus nerve.Federation Proc.1987,46:30-35
8 Leslie RA.Neuroactive substance in the dorsal vagal complex of the medulla oblongata:neucleus of the tractus solitarius area postrema,and dorsal motor nucleus of the vegus.Neurochem Int.1985,7:191-212
9 Mifflin SW,Felder RB.Synaptic mechanisms regulating cardiovascular afferent inputs,to solitary tract nucleus.Am J Physiol.1990,259:H653-661
10 Onai T,Sajim,Miura M.Functional subdivisions of the nucleus tractus solitarii of the rat as determined by circulatory and respiratory responses to electrical stimulation of the nucleus.J Auton Nerve Syst.1987,21:195-202
11 Kalia M,Fuxek,Hokfeltt,et al.Distribution of neuropeptide immunoreactive nerve terminal swith in the subnuclei of the nucleus of the tractus solitarius of the rat.J Comp Neuro,1984,222(3):409,444
12 Kalia M,Mesulam MM.Brain stem projection of sensory and motor components of the vagus complex in the cat:the cervical vagus and nodose ganglion.J Comp Neurol,1980,193:453-465
13 程世斌,罗天锡,卢光启.迷走神经背核内胃副交感节前神经元的超微结构 及联系.神经解剖学杂志,1992,8:225-229
14 Berk ML.Projections of the lateral hypothalamus and bed nucleus of the stria terminalis to the dorsal vagal complex in the pigeon.J Comp Neurol,1987,260:140-156
15 Gray TS,Magnuso DJ.Neuropeptide neuronal efferents from the bed nucleus of the stria terminalis and central amgydaloid nucleus to the dorsal vagal complex in the rat.J Comp Neurol.1987,262:365-374
16 Rinaman L,Card JP,Schwaber JS,et al.Ult(?)astructureal demonstration of a gastric monosynaptie vagal circuit in the nucleus of the solitary tract in rat.J neurosci.1989;9:1985-1996
17 Higgins GA,Hoffman GE,Wray S,et al.Distribution of neurotension-immunoreactivity within barorecerptive portions of the nucleus of the tractus solotarius and the dorsal vagal nucleus of the rat.J Comp Neurol.1984;226:155-164
18 Traub RJ,Sengupta JN,Gebhart GF.Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat.Neuroscience,1996,74(3):873-884
19 易春霞,茹立强,胡道松.迷走神经参与胃伤害性信息向下丘脑的传递.中国神经科学杂志,2004,20(5):353-356
20 Shapiro RE,Miselis RR.The centrao orgnization fo the vagus nerve innervationg the stomach of the rat.J Comp Neural.1985;238:473-488
21 Massari VJ,Shirahata M,Johnson TA,et al.Substance P mmuno -reactive nerve terminals in the dorsolateral nucleus of the tractus solitarius:roles in the baroreceptorreflex.Brain Res,1998,785(2):329-340
22 Lan CT,Wu WC,Ling EA,et al.Evidence of a direct projection from the cardiovascular reactive dorsal medulla to the intermedio -lateral cell column of the spinal cord in cats revealed by light and electron microscopy.Neuroscience,1997,77:521- 533
23 李振中,于彦铮.沿迷走神经传入的心脏感觉纤维在豚鼠左心房的分布.解剖学杂志,1998,21(2):102-104
24 陈良为,饶志仁,施际武.内脏伤害性刺激诱导的大鼠延髓内FOS表达【J].解剖学报,1995,26(2):127
25 Paton JF, Kasparov S. Sensory channel specific modulation in the nucleus of the solitary tract. J Auton Nerv Syst. 80 (2000): 117-129