首发重性抑郁障碍患者静息状态脑功能磁共振研究
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摘要
目的：
通过静息状态脑功能磁共振研究首发重性抑郁障碍患者基础状态下的脑活动特征,以探讨抑郁障碍静息状态下的脑神经功能改变。方法：
采用功能磁共振成像技术(fMRI),检测静息状态下51例首发未用药重性抑郁障碍患者(病例组)、50例性别、年龄、受教育程度与患者相匹配的对照(对照组)的脑功能活动,对两组进行两样本比较。利用REST软件分析fMRI数据,计算其全脑的ReHo、ALFF值,用SPM5软件进行两样本t检验(P<0.001)。结果：
1.一般资料组间比较：抑郁障碍病例组与对照组在性别、年龄和受教育程度方面均无显著性差异。
2.影像学结果组间比较
2.1 ReHo分析：病例组双侧额叶内侧回的局部一致性较对照组显著增强；
2.2 ALFF分析：病例组右侧额叶内侧回和右侧后扣带回的神经元活动较对照组显著增强。
结论：
1.病例组与对照组比较时,在双侧额叶内侧回均显示出ReHo值显著增强,提示这些脑区的自发活动异常可能是抑郁障碍发生的神经病理基础；
2.病例组与对照组比较时,在右侧额叶内侧回、右侧后扣带回均显示出ALFF值显著增强,提示这些脑区神经元活动的异常可能是抑郁障碍发生的神经病理基础；
3.抑郁障碍患者右侧额叶内侧回的ReHo、ALFF值均显著增强,提示右侧额叶内侧回的功能异常可能是抑郁障碍的发生的神经病理基础,也进一步提示额叶内侧回和扣带回所在的默认状态网络的异常可能在抑郁障碍的神经基础中起到了重要作用。
Objective:
We explored differences of brain spontaneous activity in resting state between depression, degree-first and controls using function magnetic resonance imaging (fMRI) in order to find the base of neural activity in depression associated with phathophysiological mechanism.
Methods:
51 subjects with depression and 50 sex, age and education-matched controls underwent 3 min and 40 sec fMRI scans while resting state. ReHo and ALFF analysis were used to detect neural spontaneous activity across the whole brain by REST. Two within-group analysis was performed among two groupes by t-test (P<0.001) by SPM5.
Results:
1.subjects:there were no significant differents among MDD as well as control respect to age and gender as well as education.
2. fMRI results:
2.1 ReHo analysis:The ReHo of bilateral medial frontal gyrus were significantly increased in resting state in depression compared to control;
2.2 ALFF analysis:The ALFF of right medial frontal, right cingulate gyrus were significantly increased in resting state in depression compared to controls.
Conclusion:
1. Compared to controls,the depressed patients showed the increased ReHo in bilateral medial frontal gyrus, which implicated the increased regional homogeneity of these regions may be the neuropathotogical substrate in depression;
2.The depressed patients showed the increased ALFF in right medial frontal, right cingulate gyrus, which implicated the increased amplitude of regional activity in these regions may be the neuropathotogical substrate in depression;
3.The depressed patients showed the increased both ReHo and ALFF in right medial frontal gyrus, the present result implicate that these regions play a importance role in mechanism of neuropathotogical in depression.
通过静息状态脑功能磁共振研究首发重性抑郁障碍患者基础状态下的脑活动特征,以探讨抑郁障碍静息状态下的脑神经功能改变。方法：
采用功能磁共振成像技术(fMRI),检测静息状态下51例首发未用药重性抑郁障碍患者(病例组)、50例性别、年龄、受教育程度与患者相匹配的对照(对照组)的脑功能活动,对两组进行两样本比较。利用REST软件分析fMRI数据,计算其全脑的ReHo、ALFF值,用SPM5软件进行两样本t检验(P<0.001)。结果：
1.一般资料组间比较：抑郁障碍病例组与对照组在性别、年龄和受教育程度方面均无显著性差异。
2.影像学结果组间比较
2.1 ReHo分析：病例组双侧额叶内侧回的局部一致性较对照组显著增强；
2.2 ALFF分析：病例组右侧额叶内侧回和右侧后扣带回的神经元活动较对照组显著增强。
结论：
1.病例组与对照组比较时,在双侧额叶内侧回均显示出ReHo值显著增强,提示这些脑区的自发活动异常可能是抑郁障碍发生的神经病理基础；
2.病例组与对照组比较时,在右侧额叶内侧回、右侧后扣带回均显示出ALFF值显著增强,提示这些脑区神经元活动的异常可能是抑郁障碍发生的神经病理基础；
3.抑郁障碍患者右侧额叶内侧回的ReHo、ALFF值均显著增强,提示右侧额叶内侧回的功能异常可能是抑郁障碍的发生的神经病理基础,也进一步提示额叶内侧回和扣带回所在的默认状态网络的异常可能在抑郁障碍的神经基础中起到了重要作用。
Objective:
We explored differences of brain spontaneous activity in resting state between depression, degree-first and controls using function magnetic resonance imaging (fMRI) in order to find the base of neural activity in depression associated with phathophysiological mechanism.
Methods:
51 subjects with depression and 50 sex, age and education-matched controls underwent 3 min and 40 sec fMRI scans while resting state. ReHo and ALFF analysis were used to detect neural spontaneous activity across the whole brain by REST. Two within-group analysis was performed among two groupes by t-test (P<0.001) by SPM5.
Results:
1.subjects:there were no significant differents among MDD as well as control respect to age and gender as well as education.
2. fMRI results:
2.1 ReHo analysis:The ReHo of bilateral medial frontal gyrus were significantly increased in resting state in depression compared to control;
2.2 ALFF analysis:The ALFF of right medial frontal, right cingulate gyrus were significantly increased in resting state in depression compared to controls.
Conclusion:
1. Compared to controls,the depressed patients showed the increased ReHo in bilateral medial frontal gyrus, which implicated the increased regional homogeneity of these regions may be the neuropathotogical substrate in depression;
2.The depressed patients showed the increased ALFF in right medial frontal, right cingulate gyrus, which implicated the increased amplitude of regional activity in these regions may be the neuropathotogical substrate in depression;
3.The depressed patients showed the increased both ReHo and ALFF in right medial frontal gyrus, the present result implicate that these regions play a importance role in mechanism of neuropathotogical in depression.
引文
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28 Mitterschiffthaler MT; Kumari V; Malhi GS et al.Neural response to pleasant stimuli in anhedonia:an fMRI study. Neuroreport.2003(14)2:177-182
29 Elliott R, Rubinsztein JS, Sahakian BJ, et al. The neural basis of mood-con gruente motionalp rocessingb iasesin d epression. A rchG en Psy ch iat ry,2002,59(7):5-9
30 Malhi GS, Lagopoulos J, Ward PB, Kumari V, et al. Cognitive generation of affect in bipolar depression:an fMRI study. Eur J Neurosci.2004 Feb; 19(3):7,41-54
31 Amit Anand, Yu Li,et al. Activity and connectivity of brain mood regulating circuit in depression:a functional magnetic resonance study.Biol Psychiatry.2005 May 15;57(10):1079-1088
32 K Matsuo, DC Glahn, MAM Peluso et al. Prefrontal hyperactivation during working memory task in untreated individuals with major depression disorder. Molecular Psychiatry 2006,1-19
33 Walter H, Wolf RC, Spitzer M, Vasic N. Increased left prefrontal activation in patients with unipolar depression:An event-related, parametric performance-controlled fMRI study. J Affect Disord.2007 Aug;101(1-3):170-85
34 Fitzgerald PB, Srithiran A, Benitez J et al. An fMRI study of prefrontal brain activation during multiple tasks in patients with major depressive disorder. Hum Brain Mapp.2007 May 24
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