长春市骨质疏松性骨折的流行病学调查及分析
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摘要
研究目的：了解长春市就诊患者中骨质疏松性骨折的流行病学。
研究方法：根据流行病学调查要求，收集2009年9月至2012年2月于我院骨科和康复医学科住院患者17893例，其中60岁以上脊柱及髋部骨折患者，男性和女性患者分别进行统计学分析整理。
研究结果：各种原因导致的骨折患者12601例，其中60岁以上骨质疏松性骨折患者977例，占骨折患者的7.75%，占总住院人数的5.46%。其中，女性骨质疏松性骨折患者显著多于男性，且多见于65-69岁及70-74岁两个年龄段；髋关节骨折及椎体骨折明显多于其他部位骨折；1-2月、3-4月及11-12月患者较其他月份多，即冬季至开春回暖时是骨质疏松性骨折的多发时间段；各月份患者量均逐年增长。
结论：通过本次流行病学调查研究，长春市骨质疏松性骨折的发病率特点为：1、65～74岁的老年人多发；2、女性多于男性；3、11月～4月发病率高于其他月份；4、医院住院患者以髋部骨折和脊椎骨折多见。
Objective: To survey and analyse the epidemiology of osteoporoticfractures from the patients who got treatment in Changchun City.
Method: According to the epidemiological investigation,17,893caseswere selected from the department of orthopedics and the department ofrehabilitation in China-Japan Union Hospital between September2009toFebruary2012. The data were respectively analysed in male, female and thepatients of spine and/or hip fracture who were over60years-old.
Results: there were12,601cases of fracture,977cases (7.75%) of whichwere osteoporotic fractures and the patients were over60years-old. It was5.46%of the patients in hospital. Female is more than male in these cases andthat in the age group of65-69year-old and70-74year-old were more thanothers; the fracture at hip joint and vertebral body were more than others;patients in January-February, March and April, November-December weremore than other month; patients in every month increased year by year.
Conclusion: the characteristic of osteoporotic fracture in ChangChun citywas that:1. the age group of65-69year-old and70-74year-old were more thanothers;2. the fracture at hip joint and vertebral body were more than others;3.patients in January-February, March and April, November-December weremore than other month;4. patients in every month increased year by year.
研究方法：根据流行病学调查要求，收集2009年9月至2012年2月于我院骨科和康复医学科住院患者17893例，其中60岁以上脊柱及髋部骨折患者，男性和女性患者分别进行统计学分析整理。
研究结果：各种原因导致的骨折患者12601例，其中60岁以上骨质疏松性骨折患者977例，占骨折患者的7.75%，占总住院人数的5.46%。其中，女性骨质疏松性骨折患者显著多于男性，且多见于65-69岁及70-74岁两个年龄段；髋关节骨折及椎体骨折明显多于其他部位骨折；1-2月、3-4月及11-12月患者较其他月份多，即冬季至开春回暖时是骨质疏松性骨折的多发时间段；各月份患者量均逐年增长。
结论：通过本次流行病学调查研究，长春市骨质疏松性骨折的发病率特点为：1、65～74岁的老年人多发；2、女性多于男性；3、11月～4月发病率高于其他月份；4、医院住院患者以髋部骨折和脊椎骨折多见。
Objective: To survey and analyse the epidemiology of osteoporoticfractures from the patients who got treatment in Changchun City.
Method: According to the epidemiological investigation,17,893caseswere selected from the department of orthopedics and the department ofrehabilitation in China-Japan Union Hospital between September2009toFebruary2012. The data were respectively analysed in male, female and thepatients of spine and/or hip fracture who were over60years-old.
Results: there were12,601cases of fracture,977cases (7.75%) of whichwere osteoporotic fractures and the patients were over60years-old. It was5.46%of the patients in hospital. Female is more than male in these cases andthat in the age group of65-69year-old and70-74year-old were more thanothers; the fracture at hip joint and vertebral body were more than others;patients in January-February, March and April, November-December weremore than other month; patients in every month increased year by year.
Conclusion: the characteristic of osteoporotic fracture in ChangChun citywas that:1. the age group of65-69year-old and70-74year-old were more thanothers;2. the fracture at hip joint and vertebral body were more than others;3.patients in January-February, March and April, November-December weremore than other month;4. patients in every month increased year by year.
引文
[1]刘忠厚.骨质疏松学第3版[M].北京:北京科学技术出版社,1998:246.
[2] Cauley JA，H0cllberg MC，Lui LY，et a1．Long-term risk of incidentvertebral fractures[J].JAMA,2007,298(23):276l-2767．
[3]刘忠厚,潘子昂,王石鹏,等.骨骼生长衰老规律和原发性骨质疏松症预诊的研究[J].中国骨质疏松杂志,1995,1(1):1-7.
[4] Iqbal MM. Osteoporosis：epidemiology，diagnosis，and treatment[J].Southern Medical Journal,2000,93(1):2-18
[5] Andersson G.B, Bostrom M．P，Eyll D．R, et al. Consensus summary on thediagnosis and treatment of osteoporosis [J].Spine,1997,22(24S):63-65.
[6]黄公怡.骨质疏松性骨折[J].老年医学与保健2003,9(2):94-98.
[7] Gallagher JC, Melton LJ, Riggs BL, et al. Epidemiology of fractures of theproximal femur in Rochester, Minnesota [J]. Clinical Orthopaedics andRelated Research,1980(150):163-171.
[8] Cooper C, Campion G, Melton LJ3rd. Hip fractures in the elderly: a world-wide projection [J]. Osteoporosis International,1992,2(6):285-289.
[9]吴立兵,刘刚,李伏燕,等.鄂西北正常人骨密度调查分析[J].中国骨质疏松杂志,2009,15(6):432-434
[10]阮文东,王沛,雪原,等.骨质疏松骨折后再骨折的临床风险因素[J].中华骨科杂志,2011,7:789-793
[11]Melton LJ3rd, Kearns AE, Atkinson EJ, et al. Secular trends in hipfracture incidence and recurrence[J]. Osteoporosis International,2009,20(5):687-694.
[12]闫丽娅.中国沈阳髋部骨折的流行病学研究[J].中国骨质疏松杂志,1996,2(2):69-71
[13]张薇,曹冰燕,巩纯秀.骨质疏松的危险因素研究[J].中国骨质疏松杂志,2008,14(7):519-520.
[14]徐苓,Cummings SR,秦明伟,等.北京老年妇女脊椎骨折的流行病学研究[J].中国骨质疏松杂志,1995,1(1):81-84．
[15]刘璠.骨质疏松性骨折的流行病学研究进展[J].实用老年医学,2010,24(5):356-359
[16]Yamanashi A, Yamazaki K, kanamori M,et a1．Assessment0frisk factorsfor second hip fractures in Japanese elderly[J]．Osteoporosis International,2005,16(10):1239-1246．
[17]陈阳,马剑雄,马信龙.老年性骨质疏松骨折研究进展[J].中国骨质疏松杂志,2011,17(9):835-839.
[18]王雪飞,于振山,雍宜民.体重指数和骨折危险性预测[J].中国骨质疏松杂志,2001,7(2):119-120.
[19]Gunnes M, et al. The relationship between anthropometric measurementsand fractures in women[J]. Bone,1996(19):407
[20] Jones G, Scott FS. A cross-sectional study of smoking and bone mineraldensity in premenopausal parous women: effect of body mass index,breastfeeding, and sports participation[J]. Journal of Bone and MineralResearch,1999,14(9):1628-1633
[21]Schroder HM, Petersen KK, Erlandsen M, et al. Occurrence and incidenceof the second hip fracture [J]. Clinical Orthopaedics and Related Research,1993(289):166-169
[22]谢小波,崔红岩,庞丽云,等.脉冲电磁场用于治疗骨质疏松性疼痛的疗效评估及分析[J].国际生物医学工程杂志,2011,34(2):107-110.
[23]刘诗丹.综合疗法治疗脊髓损伤继发骨质疏松症21例的临床观察[J].广西医学,2011,33(1):126-127.
[1]马洪,李文蛟,冯伟临,等.西双版纳老年人骨质疏松性骨折流行病学初步调查[J].中国骨肿瘤骨病,2009,8(5):263-265.
[2]沈霖,谢晶,杨艳萍,等.武汉地区老年人群骨质疏松性骨折发病率初步调查[J].中国中医骨伤科杂志,2001,9(5):1-5.
[3]李涛,于涛,张虎翼,等.长春地区部分老年人群髋部骨质疏松性骨折发病特点初步调查与分析[J].中国骨质疏松杂志,2011.17(5):428-430.
[4]吴立兵,刘刚,李伏燕,等.鄂西北正常人骨密度调查分析[J].中国骨质疏松杂志,2009,15(6):432-434.
[5] L í dia S à nchez-Riera, Nicholas Wilson, Narainraj Kamalaraj,et al.Osteoporosis and fragility fractures[J]. Best Practice&Research ClinicalRheumatology,2010,24(6):793-810.
[6] Carpintero P, Gil-Garay E, hernandez-Vaquero D, et al. Interventions toimprove inpatient osteoporosis management following first osteoporoticfracture: the PREVENT project[J]. Archives of Orthopaedic and TraumaSurgery,2009,129(2):245-250
[7] Wilson RT, Chase GA, Chrischilles EA, et al. Hip fracture risk amongcommunity-dwelling elderly people in the United States: a prospectivestudy of physical cognitive, and socioeconomic indicators[J]. AmericanJournal of Public Health,2006,96(7):1210-1218.
[8] Gallacher SJ, Gallagher AP, McQuillian C, et al. The prevalence ofvertebral fracture amongst patients presenting with non-vertebralfractures[J]. Osteoporosis International,2007,18(2):185-192.
[9] Center JR, Bliuc D, Nguyen TV, et al. Risk of subsequent fracture afterlow-trauma fracture in men and women[J]. The Journal of the AmericanMedical Association,2007,297(4):387-394.
[10]Leslie WD, Lix LM, Langsetmo L, et al. Construction of a FRAX modelfor the assessment of fracture probability in Canada and implications fortreatment [J]. Osteoporosis International,2011,22:817-827.
[11]Fraser LA, Langsetmo L, Berger C, et al. Fracture prediction andcalibration of a Canadian FRAX tool: a population-based report fromCaMos[J]. Osteoporosis International,2011,22:829-837.
[12]Kanis JA, McCloskey E, Johansson H, et al. FRAX with and without BoneMineral Density[J]. Calcified Tissue International,2012,90(1):1-13.
[13]Maggio D, Ruggiero C, Ercolani S, et al. A multidimensional questionnairequantifying quality of life in elderly osteoporotic women: the Italiantriple-Q Osteoporosis Study[J]. Aging Clinical and Experimental Research,2010,22(4):330-339.
[14]Rao SS, Cherukuri M. Management of hip fracture: the family physician’srole[J]. American Family Physician,2006,73(12):2195-2200.
[15]Boonen S, Dejaeger E, Vanderschueren D, et al. Osteoporosis andosteoporotic fracture occurrence and prevention in the elderly: a geriatricperspective[J]. Best Practice&Research Clinical Endocrinology&Metabolism,2008,22(5):765-785.
[16]Rizzoli R, Bruyere O, Cannata-Andia JB, et al. Management ofosteoporosis in the elderly[J]. Current Medical Research&Opinion,2009,25(10):2373-2387.
[17]Spangler M, Phillips BB, Ross MB, et al. Calcium supplementation inpostmenopausal women to reduce the risk of osteoporotic fractures[J].American Journal of Health-System Pharmacy,2011,68:309-318.
[18]Hopkins RB, Goeree R, Pullenayegum E, et al. The relative efficacy ofnine osteoporosis medications for reducing the rate of fractures inpost-menopausal women[J]. BMC Musculoskeletal Disorders,2011,12:209.
[19]Harding AK, Toksvig-Larsen S, Tagil M, et al. A single dose zoledronicacid enhances pin fixation in high tibial osteotomy using the hemicallotasistechnique. A double-blind placebo controlled randomized study in46patients[J]. Bone,2010,46(3):649-654
[20]Honig S. Osteoporosis-New Treatments and Updates[J]. Bulletin Of TheNYU Hospital For Joint Diseases,2010,68(3):166-170.
[2] Cauley JA，H0cllberg MC，Lui LY，et a1．Long-term risk of incidentvertebral fractures[J].JAMA,2007,298(23):276l-2767．
[3]刘忠厚,潘子昂,王石鹏,等.骨骼生长衰老规律和原发性骨质疏松症预诊的研究[J].中国骨质疏松杂志,1995,1(1):1-7.
[4] Iqbal MM. Osteoporosis：epidemiology，diagnosis，and treatment[J].Southern Medical Journal,2000,93(1):2-18
[5] Andersson G.B, Bostrom M．P，Eyll D．R, et al. Consensus summary on thediagnosis and treatment of osteoporosis [J].Spine,1997,22(24S):63-65.
[6]黄公怡.骨质疏松性骨折[J].老年医学与保健2003,9(2):94-98.
[7] Gallagher JC, Melton LJ, Riggs BL, et al. Epidemiology of fractures of theproximal femur in Rochester, Minnesota [J]. Clinical Orthopaedics andRelated Research,1980(150):163-171.
[8] Cooper C, Campion G, Melton LJ3rd. Hip fractures in the elderly: a world-wide projection [J]. Osteoporosis International,1992,2(6):285-289.
[9]吴立兵,刘刚,李伏燕,等.鄂西北正常人骨密度调查分析[J].中国骨质疏松杂志,2009,15(6):432-434
[10]阮文东,王沛,雪原,等.骨质疏松骨折后再骨折的临床风险因素[J].中华骨科杂志,2011,7:789-793
[11]Melton LJ3rd, Kearns AE, Atkinson EJ, et al. Secular trends in hipfracture incidence and recurrence[J]. Osteoporosis International,2009,20(5):687-694.
[12]闫丽娅.中国沈阳髋部骨折的流行病学研究[J].中国骨质疏松杂志,1996,2(2):69-71
[13]张薇,曹冰燕,巩纯秀.骨质疏松的危险因素研究[J].中国骨质疏松杂志,2008,14(7):519-520.
[14]徐苓,Cummings SR,秦明伟,等.北京老年妇女脊椎骨折的流行病学研究[J].中国骨质疏松杂志,1995,1(1):81-84．
[15]刘璠.骨质疏松性骨折的流行病学研究进展[J].实用老年医学,2010,24(5):356-359
[16]Yamanashi A, Yamazaki K, kanamori M,et a1．Assessment0frisk factorsfor second hip fractures in Japanese elderly[J]．Osteoporosis International,2005,16(10):1239-1246．
[17]陈阳,马剑雄,马信龙.老年性骨质疏松骨折研究进展[J].中国骨质疏松杂志,2011,17(9):835-839.
[18]王雪飞,于振山,雍宜民.体重指数和骨折危险性预测[J].中国骨质疏松杂志,2001,7(2):119-120.
[19]Gunnes M, et al. The relationship between anthropometric measurementsand fractures in women[J]. Bone,1996(19):407
[20] Jones G, Scott FS. A cross-sectional study of smoking and bone mineraldensity in premenopausal parous women: effect of body mass index,breastfeeding, and sports participation[J]. Journal of Bone and MineralResearch,1999,14(9):1628-1633
[21]Schroder HM, Petersen KK, Erlandsen M, et al. Occurrence and incidenceof the second hip fracture [J]. Clinical Orthopaedics and Related Research,1993(289):166-169
[22]谢小波,崔红岩,庞丽云,等.脉冲电磁场用于治疗骨质疏松性疼痛的疗效评估及分析[J].国际生物医学工程杂志,2011,34(2):107-110.
[23]刘诗丹.综合疗法治疗脊髓损伤继发骨质疏松症21例的临床观察[J].广西医学,2011,33(1):126-127.
[1]马洪,李文蛟,冯伟临,等.西双版纳老年人骨质疏松性骨折流行病学初步调查[J].中国骨肿瘤骨病,2009,8(5):263-265.
[2]沈霖,谢晶,杨艳萍,等.武汉地区老年人群骨质疏松性骨折发病率初步调查[J].中国中医骨伤科杂志,2001,9(5):1-5.
[3]李涛,于涛,张虎翼,等.长春地区部分老年人群髋部骨质疏松性骨折发病特点初步调查与分析[J].中国骨质疏松杂志,2011.17(5):428-430.
[4]吴立兵,刘刚,李伏燕,等.鄂西北正常人骨密度调查分析[J].中国骨质疏松杂志,2009,15(6):432-434.
[5] L í dia S à nchez-Riera, Nicholas Wilson, Narainraj Kamalaraj,et al.Osteoporosis and fragility fractures[J]. Best Practice&Research ClinicalRheumatology,2010,24(6):793-810.
[6] Carpintero P, Gil-Garay E, hernandez-Vaquero D, et al. Interventions toimprove inpatient osteoporosis management following first osteoporoticfracture: the PREVENT project[J]. Archives of Orthopaedic and TraumaSurgery,2009,129(2):245-250
[7] Wilson RT, Chase GA, Chrischilles EA, et al. Hip fracture risk amongcommunity-dwelling elderly people in the United States: a prospectivestudy of physical cognitive, and socioeconomic indicators[J]. AmericanJournal of Public Health,2006,96(7):1210-1218.
[8] Gallacher SJ, Gallagher AP, McQuillian C, et al. The prevalence ofvertebral fracture amongst patients presenting with non-vertebralfractures[J]. Osteoporosis International,2007,18(2):185-192.
[9] Center JR, Bliuc D, Nguyen TV, et al. Risk of subsequent fracture afterlow-trauma fracture in men and women[J]. The Journal of the AmericanMedical Association,2007,297(4):387-394.
[10]Leslie WD, Lix LM, Langsetmo L, et al. Construction of a FRAX modelfor the assessment of fracture probability in Canada and implications fortreatment [J]. Osteoporosis International,2011,22:817-827.
[11]Fraser LA, Langsetmo L, Berger C, et al. Fracture prediction andcalibration of a Canadian FRAX tool: a population-based report fromCaMos[J]. Osteoporosis International,2011,22:829-837.
[12]Kanis JA, McCloskey E, Johansson H, et al. FRAX with and without BoneMineral Density[J]. Calcified Tissue International,2012,90(1):1-13.
[13]Maggio D, Ruggiero C, Ercolani S, et al. A multidimensional questionnairequantifying quality of life in elderly osteoporotic women: the Italiantriple-Q Osteoporosis Study[J]. Aging Clinical and Experimental Research,2010,22(4):330-339.
[14]Rao SS, Cherukuri M. Management of hip fracture: the family physician’srole[J]. American Family Physician,2006,73(12):2195-2200.
[15]Boonen S, Dejaeger E, Vanderschueren D, et al. Osteoporosis andosteoporotic fracture occurrence and prevention in the elderly: a geriatricperspective[J]. Best Practice&Research Clinical Endocrinology&Metabolism,2008,22(5):765-785.
[16]Rizzoli R, Bruyere O, Cannata-Andia JB, et al. Management ofosteoporosis in the elderly[J]. Current Medical Research&Opinion,2009,25(10):2373-2387.
[17]Spangler M, Phillips BB, Ross MB, et al. Calcium supplementation inpostmenopausal women to reduce the risk of osteoporotic fractures[J].American Journal of Health-System Pharmacy,2011,68:309-318.
[18]Hopkins RB, Goeree R, Pullenayegum E, et al. The relative efficacy ofnine osteoporosis medications for reducing the rate of fractures inpost-menopausal women[J]. BMC Musculoskeletal Disorders,2011,12:209.
[19]Harding AK, Toksvig-Larsen S, Tagil M, et al. A single dose zoledronicacid enhances pin fixation in high tibial osteotomy using the hemicallotasistechnique. A double-blind placebo controlled randomized study in46patients[J]. Bone,2010,46(3):649-654
[20]Honig S. Osteoporosis-New Treatments and Updates[J]. Bulletin Of TheNYU Hospital For Joint Diseases,2010,68(3):166-170.