对生物分子具有特异性电化学响应的离子液体—纳米复合材料界面的构筑
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摘要
本论文主要用离子液体和纳米材料修饰基体电极,利用它们特殊的化学性质及生物相容性制备新型的电化学生物传感器,用于生物小分子的无酶催化检测。
论文主要由五部分组成,第一部分综述了离子液体电化学传感器和纳米材料及其在在电化学生物催化检测中的应用;第二、三部分分别研究了离子液体和镍纳米粒子制备无酶电化学生物传感器,所制备的生物传感器可成功实现对葡萄糖的无酶检测。第四、五部分采用离子液体、六氰铁根络合物制备用于嘌呤检测的新型电化学生物传感器。用电化学方法对传感器进行了表征和条件的优化,制得的电化学生物传感器可灵敏地检测嘌呤。
In this paper, several sensitive electrochemical biosensors were successfully realized on ionic liquid and nanocomposites modified electrodes. The resulted electrochemical biosensors were prepared and used to detect biologic molecule.
The paper is made up of five parts. Firstly, a summary referring to the development of the ionic liquid electrochemical biosensor and the application in biosensing of nanocomposites are reviewed. The second part and the third part are reported on two novel nonenzymatic amperometric glucose biosensors based on ionic liquid and Nickel nanoparticle. The loading of the ionic liquid and Nickel nanoparticle are greatly enhanced and the sensitivity for the glucose detection is markedly improved. In the fourth part and the fifth part, hexacyanoferrate nanoparticles membranes on the carbon ionic liquid electrode are constructed for the electrochemical sensing of the guanine and adenine detection. The conditions for the modified electrode are optimized and the biosensors also have good selectivity, stability and reproducibility.
论文主要由五部分组成,第一部分综述了离子液体电化学传感器和纳米材料及其在在电化学生物催化检测中的应用;第二、三部分分别研究了离子液体和镍纳米粒子制备无酶电化学生物传感器,所制备的生物传感器可成功实现对葡萄糖的无酶检测。第四、五部分采用离子液体、六氰铁根络合物制备用于嘌呤检测的新型电化学生物传感器。用电化学方法对传感器进行了表征和条件的优化,制得的电化学生物传感器可灵敏地检测嘌呤。
In this paper, several sensitive electrochemical biosensors were successfully realized on ionic liquid and nanocomposites modified electrodes. The resulted electrochemical biosensors were prepared and used to detect biologic molecule.
The paper is made up of five parts. Firstly, a summary referring to the development of the ionic liquid electrochemical biosensor and the application in biosensing of nanocomposites are reviewed. The second part and the third part are reported on two novel nonenzymatic amperometric glucose biosensors based on ionic liquid and Nickel nanoparticle. The loading of the ionic liquid and Nickel nanoparticle are greatly enhanced and the sensitivity for the glucose detection is markedly improved. In the fourth part and the fifth part, hexacyanoferrate nanoparticles membranes on the carbon ionic liquid electrode are constructed for the electrochemical sensing of the guanine and adenine detection. The conditions for the modified electrode are optimized and the biosensors also have good selectivity, stability and reproducibility.
引文
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