鳜凋亡相关基因的克隆与功能研究
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摘要
鳜(Siniperca chuatsi)是我国一种重要的淡水养殖鱼类,但是各种疾病的发生严重影响着其产量,免疫防治是控制疾病的重要而有效的途径。细胞凋亡是鱼类非特异性免疫调节的一个重要方面,本文对鳜凋亡相关基因进行了克隆鉴定及功能研究。
通过构建SMART cDNA文库并结合RACE技术首次在鳜中克隆到三个凋亡相关基因,并采用PCR和Genome Walking的方法克隆这三个基因及其启动子区域。鳜肿瘤坏死因子相关的凋亡诱导配体(ScTRAIL)基因cDNA全长1359 bp,5′和3′非翻译区分别为112 bp和395 bp,开放阅读框包含852 bp,编码283 aa,基因全长9021 bp,含有6个外显子和5个内含子。启动子区域732 bp,缺乏典型的TATA或CAAT结构,但存在Oct-1、Sp-1、NF-1、RAP-1、C/EBPalp、NF-kappaB和AP-1等潜在的转录因子结合位点。
鳜肿瘤坏死因子相关的凋亡诱导配体的诱骗受体(ScDcTRAILR)基因,cDNA全长2494 bp,5′和3′非编码区分别为106 bp和1326 bp,开放阅读框包含1062 bp,编码353 aa,基因全长10437 bp,含有10个外显子和9个内含子。启动子区域804 bp,缺乏典型的TATA框或CAAT盒,但有一些特异的转录因子结合位点,如C/EBPalp、Sp-1、Oct-1和GATA-1等。
鳜Mst3和SOK1相关激酶(ScMASK)基因,cDNA全长1743 bp,5′和3′非编码区分别为161 bp和364 bp,开放阅读框包含1218 bp,编码405 aa,基因全长8561 bp,包含有9个外显子和8个内含子。启动子区域1526 bp,缺乏典型的TATA框或CAAT盒,存在Oct-1、Sp-1、NF-1、RAP-1、C/EBPalp、NF-kappaB和AP-1等潜在的转录因子结合位点。Southern blotting分析表明在鳜基因组中,ScTRAIL基因为单拷贝基因,在此基础上采用荧光定量PCR方法揭示ScDcTRAILR和ScMASK基因也是单拷贝基因。
对三个基因转录和表达产物的器官组织分布进行了详细的分析。RT-PCR表明这三个基因在健康鳜组织中呈组成型表达,且三者具有不同的组织分布模式。分别构建ScTRAIL、ScDcTRAILR和ScMASK基因的原核表达质粒,通过原核表达、表达蛋白纯化、并制备多克隆抗体,对头肾、肾脏、肝脏、脾脏、肠、皮肤、心脏、脑、鳃和心
The mandarin fish Siniperca chuatsi is an important species in China’s aquaculture. The culture of the mandarin fish has been threatened seriously by many kinds of diseases. It is thus important and necessary to develop some effective methods for the control of diseases. The understanding of immune system in this fish will provide a base for such development. The present study aimed to clone some apoptosis-related genes for the mandarin fish, with their apoptotic function analyzed in cell lines.
Three apoptosis related genes were cloned for the first time in the mandarin fish, i.e. TNF-related apoptosis-inducing ligand (TRAIL), a TRAIL decoy receptor (DcScTRAILR) and Mst3 and SOK1-related kinase (MASK) which are named as ScTRAIL, and ScDcTRAIL, and ScMASK. ScRAIL gene with the full-length cDNA of 1359 bp contains an open reading frame coding for a 283 aa protein; it’s full length genome has 9021 bp which contains six exons and five introns. The promoter region of ScTRAIL is 732 bp, which contains some putative transcription factor binding sites such as Oct-1, Sp-1, NF-1, RAP-1, C/EBPalp, NF-kappaB and AP-1; however, it lacks typical TATA or CAAT box. The ScDcTRAILR gene with the full-length cDNA of 2494 bp contains an open reading frame coding for a 353 aa protein; its full-length genome sequence is 10437 bp which contains ten exons and nine introns. The promoter region of ScDcTRAILR is 804 bp, which contains some putative transcription factor binding sites such as C/EBPalp、Sp-1、Oct-1 and GATA-1, but it lacks
通过构建SMART cDNA文库并结合RACE技术首次在鳜中克隆到三个凋亡相关基因,并采用PCR和Genome Walking的方法克隆这三个基因及其启动子区域。鳜肿瘤坏死因子相关的凋亡诱导配体(ScTRAIL)基因cDNA全长1359 bp,5′和3′非翻译区分别为112 bp和395 bp,开放阅读框包含852 bp,编码283 aa,基因全长9021 bp,含有6个外显子和5个内含子。启动子区域732 bp,缺乏典型的TATA或CAAT结构,但存在Oct-1、Sp-1、NF-1、RAP-1、C/EBPalp、NF-kappaB和AP-1等潜在的转录因子结合位点。
鳜肿瘤坏死因子相关的凋亡诱导配体的诱骗受体(ScDcTRAILR)基因,cDNA全长2494 bp,5′和3′非编码区分别为106 bp和1326 bp,开放阅读框包含1062 bp,编码353 aa,基因全长10437 bp,含有10个外显子和9个内含子。启动子区域804 bp,缺乏典型的TATA框或CAAT盒,但有一些特异的转录因子结合位点,如C/EBPalp、Sp-1、Oct-1和GATA-1等。
鳜Mst3和SOK1相关激酶(ScMASK)基因,cDNA全长1743 bp,5′和3′非编码区分别为161 bp和364 bp,开放阅读框包含1218 bp,编码405 aa,基因全长8561 bp,包含有9个外显子和8个内含子。启动子区域1526 bp,缺乏典型的TATA框或CAAT盒,存在Oct-1、Sp-1、NF-1、RAP-1、C/EBPalp、NF-kappaB和AP-1等潜在的转录因子结合位点。Southern blotting分析表明在鳜基因组中,ScTRAIL基因为单拷贝基因,在此基础上采用荧光定量PCR方法揭示ScDcTRAILR和ScMASK基因也是单拷贝基因。
对三个基因转录和表达产物的器官组织分布进行了详细的分析。RT-PCR表明这三个基因在健康鳜组织中呈组成型表达,且三者具有不同的组织分布模式。分别构建ScTRAIL、ScDcTRAILR和ScMASK基因的原核表达质粒,通过原核表达、表达蛋白纯化、并制备多克隆抗体,对头肾、肾脏、肝脏、脾脏、肠、皮肤、心脏、脑、鳃和心
The mandarin fish Siniperca chuatsi is an important species in China’s aquaculture. The culture of the mandarin fish has been threatened seriously by many kinds of diseases. It is thus important and necessary to develop some effective methods for the control of diseases. The understanding of immune system in this fish will provide a base for such development. The present study aimed to clone some apoptosis-related genes for the mandarin fish, with their apoptotic function analyzed in cell lines.
Three apoptosis related genes were cloned for the first time in the mandarin fish, i.e. TNF-related apoptosis-inducing ligand (TRAIL), a TRAIL decoy receptor (DcScTRAILR) and Mst3 and SOK1-related kinase (MASK) which are named as ScTRAIL, and ScDcTRAIL, and ScMASK. ScRAIL gene with the full-length cDNA of 1359 bp contains an open reading frame coding for a 283 aa protein; it’s full length genome has 9021 bp which contains six exons and five introns. The promoter region of ScTRAIL is 732 bp, which contains some putative transcription factor binding sites such as Oct-1, Sp-1, NF-1, RAP-1, C/EBPalp, NF-kappaB and AP-1; however, it lacks typical TATA or CAAT box. The ScDcTRAILR gene with the full-length cDNA of 2494 bp contains an open reading frame coding for a 353 aa protein; its full-length genome sequence is 10437 bp which contains ten exons and nine introns. The promoter region of ScDcTRAILR is 804 bp, which contains some putative transcription factor binding sites such as C/EBPalp、Sp-1、Oct-1 and GATA-1, but it lacks
引文
陈锦文. 一种简易适用的鳜鱼主养方式总结. 中国水产. 1996, 11:26.
梁银铨, 崔希群. 鳜鱼人工繁殖的生态生理学特征. 水生生物学报. 1992, 16:90-92.
刘焕章, 陈宜瑜. 鳜类系统发育的研究及若干种类的有效性探讨. 动物学研究. 1994, 15(增刊):1-12.
刘家寿. 鳜和乌鳢幼鱼生长及能量收支的比较研究. 中国科学院水生生物研究所博士学位论文. 1998.
孙宝剑. 鳜非特异性免疫因子的分子克隆.中国科学院水生生物研究所博士学位论文. 2004.
孙进金. 鳜鱼人工繁殖和苗种培育的研究. 水利渔业. 1987, 6:42-44.
张国华, 曹文宣, 陈宜瑜. 湖泊放养渔业对我国湖泊生态系统的影响. 水生生物学报. 1997, 21:271-228.
张鋆. 荧光实时定量 PCR 技术初探. 生命科学趋势. 2003, 12:1-28.
Abdalla SA, Horiuchi H, Furusawa S, Matsuda H. Molecular cloning and characterization of chicken tumor necrosis factor (TNF)-superfamily ligands, CD30L and TNF-related apoptosis inducing ligand (TRAIL). J Vet Med Sci. 2004, 66:643-650.
Abelli L, Baldassini MR, Meschini R, Mastrolia L. Apoptosis of thymocytes in developing sea bass Dicentrarchus labrax (L.). Fish Shellfish Immumol. 1998, 8:13-24.
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25:3389-3402.
Arason VA, Kristinsson KG, Sigurdsson JA, Stefansdottir G, Molstad S, Gudmundsson S. Do antimicrobials increase the carriage rate of penicillin resistant pneumococci in children?Cross sectional prevalence study. BMJ. 1996, 313:387-391.
Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, Youle RJ. Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J. 2003, 22:4385?4399.
Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science. 1998, 281:1305-1308.
Baetu TM, Hiscott J. On the TRAIL to apoptosis. Cytokine Growth Factor Rev. 2002, 13:199-207.
Baetu TM, Kwon H, Sharma S, Grandvaux N, Hiscott J. Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression. J Immunol. 2001, 167:3164-3173.
Baker SJ, Reddy EP. Modulation of life and death by the TNF receptor superfamily. Oncogene. 1998, 17:3261–3270.
Bemelmans MH, van Tits LJ, Buurman WA. Tumor necrosis factor: function, release and clearance. Crit Rev Immunol. 1996, 16:1-11.
Bernard D, Quatannens B, Vandenbunder B, Abbadie C. Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1. J. Biol. Chem. 2001, 276: 27322-27328.
Bobe J, Goetz FW. A tumor necrosis factor decoy receptor homologue is up-regulated in the brook trout (Salvelinus fontinalis) ovary at the completion of ovulation. Biol Reprod. 2000, 62:420-426.
Bobe J, Goetz FW. Molecular cloning and expression of a TNF receptor and two TNF ligands in the fish ovary. Comp Biochem Physiol B Biochem Mol Biol. 2001, 129:475-481.
Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-induced cell death.Cell. 1996, 85:803-815.
Briggs MR, Kadonaga JT, Bell SP, Tjian R. Purification and biochemical characterization of the promoter-specific transcription factor, Sp1.Science. 1986, 234:47-52.
Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell. 1993, 72: 847-856.
Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.Nature. 1995, 376:599-602.
Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A. 1975, 72:3666-3670.
Chang MX, Nie P, Xie HX, Wang GL, Gao Y. Characterization and expression analysis of TNF-related apoptosis inducing ligand (TRAIL) in grass carp Ctenopharyngodon idella. Vet Immunol Immunopathol. 2006, 110:51-63.
Chen MC, Gong HY, Cheng CY, Wang JP, Hong JR, Wu JL. Cloning and characterization of a novel nuclear Bcl-2 family protein, zfMcl-1a, in zebrafish embryo. Biochem Biophys Res Commun. 2000, 279:725-731.
Chen MC, Gong HY, Cheng CY, Wang JP, Hong JR, Wu JL. Cloning and characterization of zfBLP1, a Bcl-XL homologue from the zebrafish, Danio rerio. Biochim Biophys Acta. 2001, 1519:127-133.
Chen JN, Fishman MC. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development. 1996, 122:3809-3816.
Cheng R, Ford BL, O'Neal PE, Mathews CZ, Bradford CS, Thongtan T, Barnes DW, Hendricks JD, Bailey GS. Zebrafish (Danio rerio) p53 tumor suppressor gene: cDNA sequence and expression during embryogenesis. Mol Mar Biol Biotechnol. 1997, 6:88-97.
Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J. Biol. Chem. 1997, 272: 32401-32410.
Chimonczyk S, Monge D. Flow cytometry as a tool for assessment of the fish cellular immune response to pathogens. Fish and Shellfish Immunol. 1998, 9:319-333.
Chinchar VG, Bryan L, Wang J, Long S, Chinchar GD. Induction of apoptosis in frog virus 3-infected cells. Virology. 2003, 306:303-312.
Collette Y, Gilles A, Pontarotti P, Olive D. A co-evolution perspective of the TNFSF and TNFRSF families in the immune system. Trends Immunol. 2003, 24:387-394.
Cotter TG, Martin SJ. Techniques in Apoptosis. Landon: Portland Press Ltd. 1996, 1-119.
Cowling V, Downward J. Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: Absolute requirement for removal of caspase-6 prodomain. Cell Death Differ. 2002, 9: 1046-1056.
Creasy CL, Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene. 1995, 167:303-306.
Creasy CL, Chernoff J. Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem. 1995, 270:21695-21700.
Dan I, Ong SE, Watanabe NM, Blagoev B, Nielsen MM, Kajikawa E, Kristiansen TZ, Mann M, Pandey A. Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. J Biol Chem. 2002, 277:5929-5939.
Dan I, Watanabe NM, Kusumi A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 2001, 11:220-230.
Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, Ch'En P, Xu XN, Jin BQ, Pezzella F, Screaton GR. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res. 2005, 15:430-438.
Degli-Esposti MA, Dougall WC, Smolak PJ, Waugh JY, Smith CA, Goodwin RG. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity. 1997, 7: 813-820.
Degli-Esposti MA, Smolak PJ, Walczak H, Waugh J, Huang CP, DuBose RF, Goodwin RG, Smith CA. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family.J Exp Med. 1997, 186:1165-1170.
DeWitte-Orr SJ, Bols NC. Gliotoxin-induced cytotoxicity in three salmonid cell lines: cell death by apoptosis and necrosis. Comp Biochem Physiol C Toxicol Pharmacol. 2005, 141:157-167.
Diener K, Wang XS, Chen C, Meyer CF, Keesler G, Zukowski M, Tan TH, Yao Z. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc Natl Acad Sci U S A. 1997, 94:9687-9692.
Du C, Zhang Q, Li C, Miao D, Gui J. Induction of apoptosis in a carp leucocyte cell line infected with turbot (Scophthalmus maximus L.) rhabdovirus. Virus Res. 2004, 101:119-126.
Emery JG, McDonnell P, Burke MB, Deen KC, Lyn S, Silverman C, Dul E, Appelbaum ER, Eichman C, DiPrinzio R, Dodds RA, James IE, Rosenberg M, Lee JC, Young PR. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J. Biol. Chem. 1998, 273: 14363-14367.
Essbauer S, Ahne W. The epizootic haematopoietic necrosis virus (Iridoviridae) induces apoptosis in vitro. J Vet Med. 2002, 49:25-30.
Evans DL, Leary JH 3rd, Jaso-Friedmann L. Nonspecific cytotoxic cells and innate immunity: regulation by programmed cell death. Dev Comp Immunol. 2001, 25:791-805.
Fan TJ, Han LH, Cong RS, Liang J. Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai). 2005, 37:719-727.
Felsenstein J. Counting phylogenetic invariants in some simple cases. J Theor Biol. 1991, 152:357-376.
Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci U S A. 1996, 93:7464-7469.
Finkel E. The mitochondrion: Is it central to apoptosis? Science. 2001, 292: 624-626. Fournel S, Genestier L, Robinet E, Flacher M, Revillard JP. Human T cells require IL-2 but not G1/S transition to acquire susceptibility to Fas-mediated apoptosis. J. Immunol.1. 1996, 57: 4309-4315.
Fu YF, Fan TJ. Bcl-2 family proteins and apoptosis. Acta Biochim Biophys Sin. 2002, 34: 389-394.
Gao Q, Nie P, Yao WJ. Evidence of host blood feeding by the monogenean, Ancyrocephalus mogurndae (Monogenea: Ancyrocephalidae) from the gills of mandarin fish, Siniperca chuatsi. Folia Parasitol. 1999, 46:107-111.
Garcia-Castillo J, Pelegrin P, Mulero V, Meseguer J. Molecular cloning and expression analysis of tumor necrosis factor alpha from a marine fish reveal its constitutive expression and ubiquitous nature. Immunogenetics. 2002, 54:200-207.
Goetz FW, Planas JV, MacKenzie S. Tumor necrosis factors. Dev Comp Immunol. 2004, 28:487-497.
Gogal RM Jr, Smith BJ, Robertson JL, Smith SA, Holladay SD. Tilapia (Oreochromis niloticus) dosed with azathioprine display immune effects similar to those seen in mammals, including apoptosis.Vet Immunol Immunopathol. 1999, 68:209-227.
Gong B, Almasan A. Genomic organization and transcriptional regulation of human Apo2/TRAIL gene. Biochem Biophys Res Commun. 2000, 278:747-752.
Granger GA, Williams TW. Lymphocyte cytotoxicity in vitro: activation and release of a cytotoxic factor. Nature. 1968, 218:1253-1254.
Gray PW, Aggarwal BB, Benton CV, Bringman TS, Henzel WJ, Jarrett JA, Leung DW, Moffat B, Ng P, Svedersky LP, et al. Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. Nature. 1984, 312: 721-724.
Green DR. Apoptosis: Death deceiver. Nature. 1998, 396: 629-630.
Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998, 281:1309-1312.
Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 1995, 270:1189-1192.
Guo YX, Wei T, Dallmann K, Kwang J. Induction of caspase-dependent apoptosis by betanodaviruses GGNNV and demonstration of protein alpha as an apoptosis inducer.Virology. 2003, 308:74-82.
Hanks SK, Hunter T. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 1995, 9:576-596.
Harrop JA, McDonnell PC, Brigham-Burke M, Lyn SD, Minton J, Tan KB, Dede K, Young PR. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. J. Biol. Chem. 1998, 273: 27548-27556.
Hashimoto M, Heinrich G. Brain-derived neurotrophic factor gene expression in the developing zebrafish. Int J Dev Neurosci. 1997, 15:983-997.
Hengartner MO. The biochemistry of apoptosis.Nature. 2000, 407:770-776.
Holladay SD, Smith SA, Besteman EG, Deyab AS, Gogal RM, Hrubec T, Robertson JL, Ahmed SA. Benzo[a]pyrene-induced hypocellularity of the pronephros in tilapia (Oreochromis niloticus) is accompanied by alterations in stromal and parenchymal cells and by enhanced immune cell apoptosis. Vet Immunol Immunopathol. 1998, 64:69-82.
Hong JR, Huang LJ, Wu JL. Aquatic birnavirus induces apoptosis through activated caspase-8 and -3 in a zebrafish cell line. J. Fish Dis. 2005, 28:133-140.
Hong JR, Lin TL, Hsu YL, Wu JL. Apoptosis precedes necrosis of fish cell line with infectious pancreatic necrosis virus infection. Virology. 1998, 250:76-84.
Hong JR, Hsu YL, Wu JL. Infectious pancreatic necrosis virus induces apoptosis due to down-regulation of survival factor MCL-1 protein expression in a fish cell line.Virus Res. 1999, 63:75-83.
Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl. Acad. Sci. 1999, 96:3540-3545. Hu GB, Cong RS, Fan TJ, Mei XG. Induction of apoptosis in a flounder gill cell line by lymphocystis disease virus infection. J Fish Dis. 2004, 27:657-662.
Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes. Dev. 1996, 10:2251-2264.
Hu S, Yang X. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD.J Biol Chem. 2000, 275:30761-30764.
Hymowitz SG, Christinger HW, Fuh G, Ultsch M, O'Connell M, Kelley RF, Ashkenazi A, de Vos AM. Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol Cell. 1999, 4:563-571.
Inohara N, Nunez G. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell Death Differ. 2000, 7:509-510.
Itami T, Ishida Y, Endo F, Kawazoe N, Takahashi Y. Haemagglutinins in the skin mucus of ayu. Fish Pathol. 1993, 28:41-47.
Ito S, Wakabayashi K, Ubukata O, Hayashi S, Okada F, Hata T. Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. J. Biol. Chem. 2002, 277:6631-6636.
Janz DM, Van Der Kraak G. Suppression of apoptosis by gonadotropin, 17beta-estradiol, and epidermal growth factor in rainbow trout preovulatory ovarian follicles. Gen Comp Endocrinol. 1997, 105:186-193.
Jaso-Friedmann L, Ruiz J, Bishop GR, Evans DL. Regulation of innate immunity in tilapia: activation of nonspecific cytotoxic cells by cytokine-like factors. Dev Comp Immunol. 2000, 24:25-36.
Jiang X, Wang X. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to apaf-1. J Biol Chem. 2000, 275:31199-311203.
Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zuniga-Pflucker JC, Kroemer G, Penninger JM. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001, 410:549-554. Kandel ES, Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res. 1999, 253:210-229.
Kayagaki N, Yamaguchi N, Nakayama M, Eto H, Okumura K, Yagita H. Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs. J Exp Med. 1999a, 189:1451-1460.
Kayagaki N, Yamaguchi N, Nakayama M, Takeda K, Akiba H, Tsutsui H, Okamura H, Nakanishi K, Okumura K, Yagita H. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J Immunol. 1999b, 163:1906-1913.
Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972, 26:239-257.
Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N, Pawson T, Woodgett JR, Iscove NN. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996, 15:7013-7025.
Kumar S, Vaux DL. Apoptosis. A cinderella caspase takes center stage. Science. 2002, 297:1290-1291.
Krumschnabel G, Manzl C, Berger C, Hofer B. Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes. Toxicol Appl Pharmacol. 2005, 209:62-73.
Kuramochi S, Moriguchi T, Kuida K, Endo J, Semba K, Nishida E, Karasuyama H. LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. J Biol Chem. 1997, 272:22679-22684.
Kyriakis JM. Signaling by the germinal center kinase family of protein kinases. J Biol Chem. 1999, 274:5259-5262.
Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev. 2001, 81:807-869.
Laing KJ, Wang T, Zou J, Holland J, Hong S, Bols N, Hirono I, Aoki T, Secombes CJ. Cloning and expression analysis of rainbow trout Oncorhynchus mykiss tumor necrosis factor-alpha. Eur J Biochem. 2001, 268:1315-1322.
Langheinrich U, Hennen E, Stott G, Vacun G. Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol. 2002, 12:2023-2028.
LeBlanc HN, Ashkenazi A. Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ. 2003, 10:66-75.
Lee KK, Yonehara S. Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J Biol Chem. 2002, 277:12351-12358.
Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998, 94:491-501.
Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene. 2001, 20:6559-6569.
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001, 25:402-408. Lockshin RA, Zakeri Z. Programmed cell death and apoptosis: origins of the theory. Nat Rev Mol Cell Biol. 2001, 2:545-550.
Long Q, Huang H, Shafizadeh E, Liu N, Lin S. Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish. Nat Cell Biol. 2000, 2:549-552.
Lorenzen N, Lapatra SE. Immunity to rhabdoviruses in rainbow trout: the antibody response. Fish Shellfish Immunol. 1999, 172:41-61.
Lorenzen N, Olesen N, Koch C. Immunity to VHS virus in rainbow trout resistant to viral haemorrhagic septicaemia virus and transmission of resistance by gynogenesis. Vet Res. 1995, 26:361-368.
Lü CX, Fan TJ, Hu GB, Cong RS. Apoptosis-inducing factor and apoptosis. Acta Biochim Biophys Sin. 2003, 35:881-885. Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider P, Tschopp J, Browning JL. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med. 1999, 190:1679-1710.
Malicki J, Neuhauss SC, Schier AF, Solnica-Krezel L, Stemple DL, Stainier DY, Abdelilah S, Zwartkruis F, Rangini Z, Driever W. Mutations affecting development of the zebrafish retina. Development. 1996, 123:263-273.
Marsters SA, Yan M, Pitti RM, Haas PE, Dixit VM, Ashkenazi A. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr Biol. 2000, 10:785-788.
Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol. 1997, 7:1003-1006.
Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu GL, Ruben S, Murphy M, Eisenberg RJ, Cohen GH, Spear PG, Ware CF. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity. 1998, 8:21-30.
Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem. 1999, 274:33166-33176.
Miller NW, Deuter A, Clem LW. Phylogeny of lymphocyte heterogeneity: the cellular requirements for the mixed leucocyte reaction in channel catfish. Immunology. 1986, 59:123-128.
Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase. J. Biol. Chem. 1999, 274:15978-15981.
Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell. 1996, 85:817-827.
Myokai F, Takashiba S, Lebo R, Amar S. A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. Proc Natl Acad Sci U S A. 1999, 96:4518-4523.
Nagata S, Suda T. Fas and Fas ligand: lpr and gld mutations. Immunol Today. 1995, 16:39-43.
Nicholson DW, Thornberry NA. Apoptosis: Life and death decisions. Science. 2003, 299:214-215.
Nie P. Co-occurrence and microhabitat of Ancyrocephalus mogurndae (Monogenea) and Henneguya weishanensis (Myxosporea) on the gills of the mandarin fish, Siniperca chuatsi. Folia Parasitol. 1996, 43:272-276.
Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S. YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Oncogene. 1997, 14:2047-2057.
Pan G, Ni J, Wei Y, Yu G, Gentz R, Dixit VM. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science. 1997, 277: 815-818.
Pan G, Ni J, Yu G, Wei YF, Dixit VM. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett. 1998, 424:41-45.
Park CI, Kurobe T, Hirono I, Aoki T. Cloning and characterization of cDNAs for two distinct tumor necrosis factor receptor superfamily genes from Japanese flounder Paralichthys olivaceus. Dev Comp Immunol. 2003, 27:365-375.
Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 1996, 271:12687-12690.
Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. EMBO J. 1996, 15:4537-4546.
Qian Z, Lin C, Espinosa R, LeBeau M, Rosner MR. Cloning and characterization of MST4, a novel Ste20-like kinase. J Biol Chem. 2001, 276:22439-22445.
Ravi R, Bedi GC, Engstrom LW, Zeng Q, Mookerjee B, Gelinas C, Fuchs EJ, Bedi A. Regulation of death receptor expression and TRAIL/Apo2L- induced apoptosis by NF-kappaB. Nat.Cell Biol. 2001, 3:409-416.
Reinhard C, Shamoon B, Shyamala V, Williams LT. Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J. 1997, 16:1080-1092.
Roberts CD. Comparative morphology of spined scales and their phylogenetic significance in the Teleostei. Bulletin of Marine Science. 1993, 52:60–113.
Rooney IA, Butrovich KD, Glass AA, Borboroglu S, Benedict CA, Whitbeck JC, Cohen GH, Eisenberg RJ, Ware CF. The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J. Biol. Chem. 2000, 275:14307-14315.
Rothe M, Wong SC, Henzel WJ, Goeddel DV. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994, 78:681-692.
Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995, 83:1243-1252.
Sabourin LA, Rudnicki MA. Induction of apoptosis by SLK, a Ste20-related kinase. Oncogene. 1999, 18:7566-7575.
Saeij JP, Stet RJ, de Vries BJ, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance? Dev Comp Immunol. 2003, 27:29-41.
Saffer JD, Jackson SP, Annarella MB. Developmental expression of Sp1 in the mouse. Mol Cell Biol. 1991, 11:2189-2199.
Saraste A, Pulkki K. Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res. 2000, 45:528-537.
Sattar R, Ali SA, Abbasi A. Molecular mechanism of apoptosis: Prediction of three-dimensional structure of caspase-6 and its interactions by homology modeling. Biochem Biophys Res Commun. 2003, 308:497-504.
Schinkmann K, Blenis J. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. J Biol Chem. 1997, 272:28695-28703.
Seol DW, Billiar TR. Cysteine 230 modulates tumor necrosis factor-related apoptosis -inducing ligand activity. Cancer Res. 2000, 60:3152-3154.
Shalaby MR, Aggarwal BB, Rinderknecht E, Svedersky LP, Finkle BS, Palladino MA Jr. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J Immunol. 1985, 135:2069-2073.
Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray CL, Baker K, Wood WI, Goddard AD, Godowski P, Ashkenazi A. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science. 1997, 277:818-821.
Shetty S, Graham BA, Brown JG, Hu X, Vegh-Yarema N, Harding G, Paul JT, Gibson SB. Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. Mol Cell Biol. 2005, 25:5404-5016.
Spierings DC, de Vries EG, Vellenga E, van den Heuvel FA, Koornstra JJ, Wesseling J, Hollema H, de Jong S. Tissue distribution of the death ligand TRAIL and its receptors. J Histochem Cytochem. 2004, 52:821-831.
Stainier DY, Fouquet B, Chen JN, Warren KS, Weinstein BM, Meiler SE, Mohideen MA, Neuhauss SC, Solnica-Krezel L, Schier AF, Zwartkruis F, Stemple DL, Malicki J, Driever W, Fishman MC. Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development. 1996, 123:285-292.
Sugden PH, Clerk A. "Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res. 1998, 83:345-352.
Su YC, Han J, Xu S, Cobb M, Skolnik EY. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 1997, 16:1279-1290.
Sun BJ, Nie P. Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi. Vet Immunol Immunopathol. 2004, 101:161-170. Sung V, Luo W, Qian D, Lee I, Jallal B, Gishizky M. The Ste20 kinase MST4 plays a role in prostate cancer progression. Cancer Res. 2003, 63:3356-3363.
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999, 397:441-446.
Sweet LI, Passino-Reder DR, Meier PG, Omann GM. Fish thymocyte viability, apoptosis and necrosis: in-vitro effects of organochlorine contaminants. Fish Shellfish Immunol. 1998, 8:77-90.
Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S. Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol.1994, 6:1567-1574.
Takeda K, Hayakawa Y, Smyth MJ, Kayagaki N, Yamaguchi N, Kakuta S, Iwakura Y, Yagita H, Okumura K. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med. 2001, 7:94-100.
Taylor LK, Wang HC, Erikson RL. Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc Natl Acad Sci. 1996, 93:10099-10104.
Thisse C, Neel H, Thisse B, Daujat S, Piette J. The Mdm2 gene of zebrafish (Danio rerio): preferential expression during development of neural and muscular tissues, and absence of tumor formation after overexpression of its cDNA during early embryogenesis. Differentiation. 2000, 66:61-70.
Tilly JL. Apoptosis and ovarian function. Rev Reprod. 1996, 1:162-172. Trabzuni D, Famulski KS, Ahmad M. Functional analysis of tumour necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL): cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumoricidal cytokine. Biochem J. 2000, 350:505-510.
Tung RM, Blenis J. A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase. Oncogene. 1997, 14:653-659.
Uchida D, Yamashita M, Kitano T, Iguchi T. Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish. J Exp Biol. 2002, 205:711-718.
Ura S, Masuyama N, Graves JD, Gotoh Y. MST1-JNK promotes apoptosis via caspase-dependent and independent pathways. Genes Cells. 2001, 6:519-530. Wajant H. Death receptors. Essays Biochem. 2003, 39:53-71.
Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T, Smith C, Smolak P, Goodwin RG, Rauch CT, Schuh JC, Lynch DH. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999, 5:157-163.
Wang CY, Mayo MW, Korneluk RG., Goeddel DV, Baldwin AS Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 1998, 281:1680-1683.
Wang J, Chun HJ, Wong W, Spencer DM, Lenardo MJ. Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci USA. 2001, 98:13884-13888.
Wang Q, Ji Y, Wang X, Evers BM. Isolation and molecular characterization of the 5'-upstream region of the human TRAIL gene. Biochem Biophys Res Commun. 2000, 276:466-471.
Wang ZB, Liu YQ, Cui YF. Pathways to caspase activation. Cell Biol Int. 2005, 29:489?496. Weyts FA, Verburg-van Kemenade BM, Flik G. Characterisation of glucocorticoid receptors in peripheral blood leukocytes of carp, Cyprinus carpio L. Gen Comp Endocrinol. 1998, 111:1-8.
Weyts FA, Verburg-van Kemenade BM, Flik G, Lambert JG, Wendelaar Bonga SE. Conservation of apoptosis as an immune regulatory mechanism: effects of cortisol and cortisone on carp lymphocytes. Brain Behav Immun. 1997, 11:95-105.
Widmann C, Gibson S, Jarpe MB, Johnson GL. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev. 1999, 79:143-180.
Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA, Goodwin RG. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995, 3:673-682.
Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner V, Liu H, Daniel TO, Smith CA, Fanslow WC. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity. 2001, 15:837-846.
Wood AW, van der Kraak G. Inhibition of apoptosis in vitellogenic ovarian follicles of rainbow trout (Oncorhynchus mykiss) by salmon gonadotropin, epidermal growth factor, and 17beta-estradiol. Mol Reprod Dev. 2002, 61:511-518.
Yabu T, Kishi S, Okazaki T, Yamashita M. Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo. Biochem J. 2001, 360:39-47.
Yao Z, Zhou G, Wang XS, Brown A, Diener K, Gan H, Tan TH. A novel human STE20- related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J Biol Chem. 1999, 274:2118-2125.
Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT mediated apoptosis. J. Biol. Chem. 1999, 274:13733-13736.
Yuan CQ, Ding ZH. Structure and function of caspases. Guowai Yixue Fenzi Shengwuxue Fence. 2002, 24:146-151.
Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell. 1993, 75:641-652.
Yue TL, Ohlstein EH, Ruffolo RR Jr. Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases. Curr Opin Chem Biol. 1999, 3:474-480.
Zhang YA, Nie P, Luo HY, Wang YP, Sun YH, Zhu ZY. Characterization of cDNA encoding immunoglobulin light chain of the mandarin fish (Siniperca chuatsi). Vet Immunol Immunopathol. 2003, 95:81-90.
Zhang YA, Nie P, Wang YP, Zhu ZY. cDNA sequence encoding immunoglobulin M heavy chain of the mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 2003, 14:477-480.
Zhivotovsky B, Orrenius S. Caspase-2 function in response to DNA damage. Biochem Biophys Res Commun. 2005, 331: 859-867.
Zhou TH, Ling K, Guo J, Zhou H, Wu YL, Jing Q, Ma L, Pei G. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. J Biol Chem. 2000, 275:2513-2519.
Zou J, Wang T, Hirono I, Aoki T, Inagawa H, Honda T, Soma GI, Ototake M, Nakanishi T, Ellis AE, Secombes CJ. Differential expression of two tumor necrosis factor genes in rainbow trout, Oncorhynchus mykiss. Dev Comp Immunol. 2002, 26:161-172.
梁银铨, 崔希群. 鳜鱼人工繁殖的生态生理学特征. 水生生物学报. 1992, 16:90-92.
刘焕章, 陈宜瑜. 鳜类系统发育的研究及若干种类的有效性探讨. 动物学研究. 1994, 15(增刊):1-12.
刘家寿. 鳜和乌鳢幼鱼生长及能量收支的比较研究. 中国科学院水生生物研究所博士学位论文. 1998.
孙宝剑. 鳜非特异性免疫因子的分子克隆.中国科学院水生生物研究所博士学位论文. 2004.
孙进金. 鳜鱼人工繁殖和苗种培育的研究. 水利渔业. 1987, 6:42-44.
张国华, 曹文宣, 陈宜瑜. 湖泊放养渔业对我国湖泊生态系统的影响. 水生生物学报. 1997, 21:271-228.
张鋆. 荧光实时定量 PCR 技术初探. 生命科学趋势. 2003, 12:1-28.
Abdalla SA, Horiuchi H, Furusawa S, Matsuda H. Molecular cloning and characterization of chicken tumor necrosis factor (TNF)-superfamily ligands, CD30L and TNF-related apoptosis inducing ligand (TRAIL). J Vet Med Sci. 2004, 66:643-650.
Abelli L, Baldassini MR, Meschini R, Mastrolia L. Apoptosis of thymocytes in developing sea bass Dicentrarchus labrax (L.). Fish Shellfish Immumol. 1998, 8:13-24.
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25:3389-3402.
Arason VA, Kristinsson KG, Sigurdsson JA, Stefansdottir G, Molstad S, Gudmundsson S. Do antimicrobials increase the carriage rate of penicillin resistant pneumococci in children?Cross sectional prevalence study. BMJ. 1996, 313:387-391.
Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, Youle RJ. Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J. 2003, 22:4385?4399.
Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science. 1998, 281:1305-1308.
Baetu TM, Hiscott J. On the TRAIL to apoptosis. Cytokine Growth Factor Rev. 2002, 13:199-207.
Baetu TM, Kwon H, Sharma S, Grandvaux N, Hiscott J. Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression. J Immunol. 2001, 167:3164-3173.
Baker SJ, Reddy EP. Modulation of life and death by the TNF receptor superfamily. Oncogene. 1998, 17:3261–3270.
Bemelmans MH, van Tits LJ, Buurman WA. Tumor necrosis factor: function, release and clearance. Crit Rev Immunol. 1996, 16:1-11.
Bernard D, Quatannens B, Vandenbunder B, Abbadie C. Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1. J. Biol. Chem. 2001, 276: 27322-27328.
Bobe J, Goetz FW. A tumor necrosis factor decoy receptor homologue is up-regulated in the brook trout (Salvelinus fontinalis) ovary at the completion of ovulation. Biol Reprod. 2000, 62:420-426.
Bobe J, Goetz FW. Molecular cloning and expression of a TNF receptor and two TNF ligands in the fish ovary. Comp Biochem Physiol B Biochem Mol Biol. 2001, 129:475-481.
Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-induced cell death.Cell. 1996, 85:803-815.
Briggs MR, Kadonaga JT, Bell SP, Tjian R. Purification and biochemical characterization of the promoter-specific transcription factor, Sp1.Science. 1986, 234:47-52.
Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell. 1993, 72: 847-856.
Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.Nature. 1995, 376:599-602.
Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A. 1975, 72:3666-3670.
Chang MX, Nie P, Xie HX, Wang GL, Gao Y. Characterization and expression analysis of TNF-related apoptosis inducing ligand (TRAIL) in grass carp Ctenopharyngodon idella. Vet Immunol Immunopathol. 2006, 110:51-63.
Chen MC, Gong HY, Cheng CY, Wang JP, Hong JR, Wu JL. Cloning and characterization of a novel nuclear Bcl-2 family protein, zfMcl-1a, in zebrafish embryo. Biochem Biophys Res Commun. 2000, 279:725-731.
Chen MC, Gong HY, Cheng CY, Wang JP, Hong JR, Wu JL. Cloning and characterization of zfBLP1, a Bcl-XL homologue from the zebrafish, Danio rerio. Biochim Biophys Acta. 2001, 1519:127-133.
Chen JN, Fishman MC. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development. 1996, 122:3809-3816.
Cheng R, Ford BL, O'Neal PE, Mathews CZ, Bradford CS, Thongtan T, Barnes DW, Hendricks JD, Bailey GS. Zebrafish (Danio rerio) p53 tumor suppressor gene: cDNA sequence and expression during embryogenesis. Mol Mar Biol Biotechnol. 1997, 6:88-97.
Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J. Biol. Chem. 1997, 272: 32401-32410.
Chimonczyk S, Monge D. Flow cytometry as a tool for assessment of the fish cellular immune response to pathogens. Fish and Shellfish Immunol. 1998, 9:319-333.
Chinchar VG, Bryan L, Wang J, Long S, Chinchar GD. Induction of apoptosis in frog virus 3-infected cells. Virology. 2003, 306:303-312.
Collette Y, Gilles A, Pontarotti P, Olive D. A co-evolution perspective of the TNFSF and TNFRSF families in the immune system. Trends Immunol. 2003, 24:387-394.
Cotter TG, Martin SJ. Techniques in Apoptosis. Landon: Portland Press Ltd. 1996, 1-119.
Cowling V, Downward J. Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: Absolute requirement for removal of caspase-6 prodomain. Cell Death Differ. 2002, 9: 1046-1056.
Creasy CL, Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene. 1995, 167:303-306.
Creasy CL, Chernoff J. Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem. 1995, 270:21695-21700.
Dan I, Ong SE, Watanabe NM, Blagoev B, Nielsen MM, Kajikawa E, Kristiansen TZ, Mann M, Pandey A. Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. J Biol Chem. 2002, 277:5929-5939.
Dan I, Watanabe NM, Kusumi A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 2001, 11:220-230.
Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, Ch'En P, Xu XN, Jin BQ, Pezzella F, Screaton GR. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res. 2005, 15:430-438.
Degli-Esposti MA, Dougall WC, Smolak PJ, Waugh JY, Smith CA, Goodwin RG. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity. 1997, 7: 813-820.
Degli-Esposti MA, Smolak PJ, Walczak H, Waugh J, Huang CP, DuBose RF, Goodwin RG, Smith CA. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family.J Exp Med. 1997, 186:1165-1170.
DeWitte-Orr SJ, Bols NC. Gliotoxin-induced cytotoxicity in three salmonid cell lines: cell death by apoptosis and necrosis. Comp Biochem Physiol C Toxicol Pharmacol. 2005, 141:157-167.
Diener K, Wang XS, Chen C, Meyer CF, Keesler G, Zukowski M, Tan TH, Yao Z. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc Natl Acad Sci U S A. 1997, 94:9687-9692.
Du C, Zhang Q, Li C, Miao D, Gui J. Induction of apoptosis in a carp leucocyte cell line infected with turbot (Scophthalmus maximus L.) rhabdovirus. Virus Res. 2004, 101:119-126.
Emery JG, McDonnell P, Burke MB, Deen KC, Lyn S, Silverman C, Dul E, Appelbaum ER, Eichman C, DiPrinzio R, Dodds RA, James IE, Rosenberg M, Lee JC, Young PR. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J. Biol. Chem. 1998, 273: 14363-14367.
Essbauer S, Ahne W. The epizootic haematopoietic necrosis virus (Iridoviridae) induces apoptosis in vitro. J Vet Med. 2002, 49:25-30.
Evans DL, Leary JH 3rd, Jaso-Friedmann L. Nonspecific cytotoxic cells and innate immunity: regulation by programmed cell death. Dev Comp Immunol. 2001, 25:791-805.
Fan TJ, Han LH, Cong RS, Liang J. Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai). 2005, 37:719-727.
Felsenstein J. Counting phylogenetic invariants in some simple cases. J Theor Biol. 1991, 152:357-376.
Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci U S A. 1996, 93:7464-7469.
Finkel E. The mitochondrion: Is it central to apoptosis? Science. 2001, 292: 624-626. Fournel S, Genestier L, Robinet E, Flacher M, Revillard JP. Human T cells require IL-2 but not G1/S transition to acquire susceptibility to Fas-mediated apoptosis. J. Immunol.1. 1996, 57: 4309-4315.
Fu YF, Fan TJ. Bcl-2 family proteins and apoptosis. Acta Biochim Biophys Sin. 2002, 34: 389-394.
Gao Q, Nie P, Yao WJ. Evidence of host blood feeding by the monogenean, Ancyrocephalus mogurndae (Monogenea: Ancyrocephalidae) from the gills of mandarin fish, Siniperca chuatsi. Folia Parasitol. 1999, 46:107-111.
Garcia-Castillo J, Pelegrin P, Mulero V, Meseguer J. Molecular cloning and expression analysis of tumor necrosis factor alpha from a marine fish reveal its constitutive expression and ubiquitous nature. Immunogenetics. 2002, 54:200-207.
Goetz FW, Planas JV, MacKenzie S. Tumor necrosis factors. Dev Comp Immunol. 2004, 28:487-497.
Gogal RM Jr, Smith BJ, Robertson JL, Smith SA, Holladay SD. Tilapia (Oreochromis niloticus) dosed with azathioprine display immune effects similar to those seen in mammals, including apoptosis.Vet Immunol Immunopathol. 1999, 68:209-227.
Gong B, Almasan A. Genomic organization and transcriptional regulation of human Apo2/TRAIL gene. Biochem Biophys Res Commun. 2000, 278:747-752.
Granger GA, Williams TW. Lymphocyte cytotoxicity in vitro: activation and release of a cytotoxic factor. Nature. 1968, 218:1253-1254.
Gray PW, Aggarwal BB, Benton CV, Bringman TS, Henzel WJ, Jarrett JA, Leung DW, Moffat B, Ng P, Svedersky LP, et al. Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. Nature. 1984, 312: 721-724.
Green DR. Apoptosis: Death deceiver. Nature. 1998, 396: 629-630.
Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998, 281:1309-1312.
Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 1995, 270:1189-1192.
Guo YX, Wei T, Dallmann K, Kwang J. Induction of caspase-dependent apoptosis by betanodaviruses GGNNV and demonstration of protein alpha as an apoptosis inducer.Virology. 2003, 308:74-82.
Hanks SK, Hunter T. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 1995, 9:576-596.
Harrop JA, McDonnell PC, Brigham-Burke M, Lyn SD, Minton J, Tan KB, Dede K, Young PR. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. J. Biol. Chem. 1998, 273: 27548-27556.
Hashimoto M, Heinrich G. Brain-derived neurotrophic factor gene expression in the developing zebrafish. Int J Dev Neurosci. 1997, 15:983-997.
Hengartner MO. The biochemistry of apoptosis.Nature. 2000, 407:770-776.
Holladay SD, Smith SA, Besteman EG, Deyab AS, Gogal RM, Hrubec T, Robertson JL, Ahmed SA. Benzo[a]pyrene-induced hypocellularity of the pronephros in tilapia (Oreochromis niloticus) is accompanied by alterations in stromal and parenchymal cells and by enhanced immune cell apoptosis. Vet Immunol Immunopathol. 1998, 64:69-82.
Hong JR, Huang LJ, Wu JL. Aquatic birnavirus induces apoptosis through activated caspase-8 and -3 in a zebrafish cell line. J. Fish Dis. 2005, 28:133-140.
Hong JR, Lin TL, Hsu YL, Wu JL. Apoptosis precedes necrosis of fish cell line with infectious pancreatic necrosis virus infection. Virology. 1998, 250:76-84.
Hong JR, Hsu YL, Wu JL. Infectious pancreatic necrosis virus induces apoptosis due to down-regulation of survival factor MCL-1 protein expression in a fish cell line.Virus Res. 1999, 63:75-83.
Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl. Acad. Sci. 1999, 96:3540-3545. Hu GB, Cong RS, Fan TJ, Mei XG. Induction of apoptosis in a flounder gill cell line by lymphocystis disease virus infection. J Fish Dis. 2004, 27:657-662.
Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes. Dev. 1996, 10:2251-2264.
Hu S, Yang X. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD.J Biol Chem. 2000, 275:30761-30764.
Hymowitz SG, Christinger HW, Fuh G, Ultsch M, O'Connell M, Kelley RF, Ashkenazi A, de Vos AM. Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol Cell. 1999, 4:563-571.
Inohara N, Nunez G. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell Death Differ. 2000, 7:509-510.
Itami T, Ishida Y, Endo F, Kawazoe N, Takahashi Y. Haemagglutinins in the skin mucus of ayu. Fish Pathol. 1993, 28:41-47.
Ito S, Wakabayashi K, Ubukata O, Hayashi S, Okada F, Hata T. Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. J. Biol. Chem. 2002, 277:6631-6636.
Janz DM, Van Der Kraak G. Suppression of apoptosis by gonadotropin, 17beta-estradiol, and epidermal growth factor in rainbow trout preovulatory ovarian follicles. Gen Comp Endocrinol. 1997, 105:186-193.
Jaso-Friedmann L, Ruiz J, Bishop GR, Evans DL. Regulation of innate immunity in tilapia: activation of nonspecific cytotoxic cells by cytokine-like factors. Dev Comp Immunol. 2000, 24:25-36.
Jiang X, Wang X. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to apaf-1. J Biol Chem. 2000, 275:31199-311203.
Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zuniga-Pflucker JC, Kroemer G, Penninger JM. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001, 410:549-554. Kandel ES, Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res. 1999, 253:210-229.
Kayagaki N, Yamaguchi N, Nakayama M, Eto H, Okumura K, Yagita H. Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs. J Exp Med. 1999a, 189:1451-1460.
Kayagaki N, Yamaguchi N, Nakayama M, Takeda K, Akiba H, Tsutsui H, Okamura H, Nakanishi K, Okumura K, Yagita H. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J Immunol. 1999b, 163:1906-1913.
Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972, 26:239-257.
Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N, Pawson T, Woodgett JR, Iscove NN. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996, 15:7013-7025.
Kumar S, Vaux DL. Apoptosis. A cinderella caspase takes center stage. Science. 2002, 297:1290-1291.
Krumschnabel G, Manzl C, Berger C, Hofer B. Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes. Toxicol Appl Pharmacol. 2005, 209:62-73.
Kuramochi S, Moriguchi T, Kuida K, Endo J, Semba K, Nishida E, Karasuyama H. LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. J Biol Chem. 1997, 272:22679-22684.
Kyriakis JM. Signaling by the germinal center kinase family of protein kinases. J Biol Chem. 1999, 274:5259-5262.
Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev. 2001, 81:807-869.
Laing KJ, Wang T, Zou J, Holland J, Hong S, Bols N, Hirono I, Aoki T, Secombes CJ. Cloning and expression analysis of rainbow trout Oncorhynchus mykiss tumor necrosis factor-alpha. Eur J Biochem. 2001, 268:1315-1322.
Langheinrich U, Hennen E, Stott G, Vacun G. Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol. 2002, 12:2023-2028.
LeBlanc HN, Ashkenazi A. Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ. 2003, 10:66-75.
Lee KK, Yonehara S. Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J Biol Chem. 2002, 277:12351-12358.
Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998, 94:491-501.
Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene. 2001, 20:6559-6569.
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001, 25:402-408. Lockshin RA, Zakeri Z. Programmed cell death and apoptosis: origins of the theory. Nat Rev Mol Cell Biol. 2001, 2:545-550.
Long Q, Huang H, Shafizadeh E, Liu N, Lin S. Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish. Nat Cell Biol. 2000, 2:549-552.
Lorenzen N, Lapatra SE. Immunity to rhabdoviruses in rainbow trout: the antibody response. Fish Shellfish Immunol. 1999, 172:41-61.
Lorenzen N, Olesen N, Koch C. Immunity to VHS virus in rainbow trout resistant to viral haemorrhagic septicaemia virus and transmission of resistance by gynogenesis. Vet Res. 1995, 26:361-368.
Lü CX, Fan TJ, Hu GB, Cong RS. Apoptosis-inducing factor and apoptosis. Acta Biochim Biophys Sin. 2003, 35:881-885. Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider P, Tschopp J, Browning JL. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med. 1999, 190:1679-1710.
Malicki J, Neuhauss SC, Schier AF, Solnica-Krezel L, Stemple DL, Stainier DY, Abdelilah S, Zwartkruis F, Rangini Z, Driever W. Mutations affecting development of the zebrafish retina. Development. 1996, 123:263-273.
Marsters SA, Yan M, Pitti RM, Haas PE, Dixit VM, Ashkenazi A. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr Biol. 2000, 10:785-788.
Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol. 1997, 7:1003-1006.
Mauri DN, Ebner R, Montgomery RI, Kochel KD, Cheung TC, Yu GL, Ruben S, Murphy M, Eisenberg RJ, Cohen GH, Spear PG, Ware CF. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity. 1998, 8:21-30.
Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem. 1999, 274:33166-33176.
Miller NW, Deuter A, Clem LW. Phylogeny of lymphocyte heterogeneity: the cellular requirements for the mixed leucocyte reaction in channel catfish. Immunology. 1986, 59:123-128.
Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase. J. Biol. Chem. 1999, 274:15978-15981.
Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell. 1996, 85:817-827.
Myokai F, Takashiba S, Lebo R, Amar S. A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. Proc Natl Acad Sci U S A. 1999, 96:4518-4523.
Nagata S, Suda T. Fas and Fas ligand: lpr and gld mutations. Immunol Today. 1995, 16:39-43.
Nicholson DW, Thornberry NA. Apoptosis: Life and death decisions. Science. 2003, 299:214-215.
Nie P. Co-occurrence and microhabitat of Ancyrocephalus mogurndae (Monogenea) and Henneguya weishanensis (Myxosporea) on the gills of the mandarin fish, Siniperca chuatsi. Folia Parasitol. 1996, 43:272-276.
Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S. YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Oncogene. 1997, 14:2047-2057.
Pan G, Ni J, Wei Y, Yu G, Gentz R, Dixit VM. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science. 1997, 277: 815-818.
Pan G, Ni J, Yu G, Wei YF, Dixit VM. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett. 1998, 424:41-45.
Park CI, Kurobe T, Hirono I, Aoki T. Cloning and characterization of cDNAs for two distinct tumor necrosis factor receptor superfamily genes from Japanese flounder Paralichthys olivaceus. Dev Comp Immunol. 2003, 27:365-375.
Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 1996, 271:12687-12690.
Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. EMBO J. 1996, 15:4537-4546.
Qian Z, Lin C, Espinosa R, LeBeau M, Rosner MR. Cloning and characterization of MST4, a novel Ste20-like kinase. J Biol Chem. 2001, 276:22439-22445.
Ravi R, Bedi GC, Engstrom LW, Zeng Q, Mookerjee B, Gelinas C, Fuchs EJ, Bedi A. Regulation of death receptor expression and TRAIL/Apo2L- induced apoptosis by NF-kappaB. Nat.Cell Biol. 2001, 3:409-416.
Reinhard C, Shamoon B, Shyamala V, Williams LT. Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J. 1997, 16:1080-1092.
Roberts CD. Comparative morphology of spined scales and their phylogenetic significance in the Teleostei. Bulletin of Marine Science. 1993, 52:60–113.
Rooney IA, Butrovich KD, Glass AA, Borboroglu S, Benedict CA, Whitbeck JC, Cohen GH, Eisenberg RJ, Ware CF. The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J. Biol. Chem. 2000, 275:14307-14315.
Rothe M, Wong SC, Henzel WJ, Goeddel DV. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994, 78:681-692.
Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995, 83:1243-1252.
Sabourin LA, Rudnicki MA. Induction of apoptosis by SLK, a Ste20-related kinase. Oncogene. 1999, 18:7566-7575.
Saeij JP, Stet RJ, de Vries BJ, van Muiswinkel WB, Wiegertjes GF. Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance? Dev Comp Immunol. 2003, 27:29-41.
Saffer JD, Jackson SP, Annarella MB. Developmental expression of Sp1 in the mouse. Mol Cell Biol. 1991, 11:2189-2199.
Saraste A, Pulkki K. Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res. 2000, 45:528-537.
Sattar R, Ali SA, Abbasi A. Molecular mechanism of apoptosis: Prediction of three-dimensional structure of caspase-6 and its interactions by homology modeling. Biochem Biophys Res Commun. 2003, 308:497-504.
Schinkmann K, Blenis J. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. J Biol Chem. 1997, 272:28695-28703.
Seol DW, Billiar TR. Cysteine 230 modulates tumor necrosis factor-related apoptosis -inducing ligand activity. Cancer Res. 2000, 60:3152-3154.
Shalaby MR, Aggarwal BB, Rinderknecht E, Svedersky LP, Finkle BS, Palladino MA Jr. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J Immunol. 1985, 135:2069-2073.
Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray CL, Baker K, Wood WI, Goddard AD, Godowski P, Ashkenazi A. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science. 1997, 277:818-821.
Shetty S, Graham BA, Brown JG, Hu X, Vegh-Yarema N, Harding G, Paul JT, Gibson SB. Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. Mol Cell Biol. 2005, 25:5404-5016.
Spierings DC, de Vries EG, Vellenga E, van den Heuvel FA, Koornstra JJ, Wesseling J, Hollema H, de Jong S. Tissue distribution of the death ligand TRAIL and its receptors. J Histochem Cytochem. 2004, 52:821-831.
Stainier DY, Fouquet B, Chen JN, Warren KS, Weinstein BM, Meiler SE, Mohideen MA, Neuhauss SC, Solnica-Krezel L, Schier AF, Zwartkruis F, Stemple DL, Malicki J, Driever W, Fishman MC. Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development. 1996, 123:285-292.
Sugden PH, Clerk A. "Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res. 1998, 83:345-352.
Su YC, Han J, Xu S, Cobb M, Skolnik EY. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 1997, 16:1279-1290.
Sun BJ, Nie P. Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi. Vet Immunol Immunopathol. 2004, 101:161-170. Sung V, Luo W, Qian D, Lee I, Jallal B, Gishizky M. The Ste20 kinase MST4 plays a role in prostate cancer progression. Cancer Res. 2003, 63:3356-3363.
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 1999, 397:441-446.
Sweet LI, Passino-Reder DR, Meier PG, Omann GM. Fish thymocyte viability, apoptosis and necrosis: in-vitro effects of organochlorine contaminants. Fish Shellfish Immunol. 1998, 8:77-90.
Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S. Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol.1994, 6:1567-1574.
Takeda K, Hayakawa Y, Smyth MJ, Kayagaki N, Yamaguchi N, Kakuta S, Iwakura Y, Yagita H, Okumura K. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med. 2001, 7:94-100.
Taylor LK, Wang HC, Erikson RL. Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc Natl Acad Sci. 1996, 93:10099-10104.
Thisse C, Neel H, Thisse B, Daujat S, Piette J. The Mdm2 gene of zebrafish (Danio rerio): preferential expression during development of neural and muscular tissues, and absence of tumor formation after overexpression of its cDNA during early embryogenesis. Differentiation. 2000, 66:61-70.
Tilly JL. Apoptosis and ovarian function. Rev Reprod. 1996, 1:162-172. Trabzuni D, Famulski KS, Ahmad M. Functional analysis of tumour necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL): cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumoricidal cytokine. Biochem J. 2000, 350:505-510.
Tung RM, Blenis J. A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase. Oncogene. 1997, 14:653-659.
Uchida D, Yamashita M, Kitano T, Iguchi T. Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish. J Exp Biol. 2002, 205:711-718.
Ura S, Masuyama N, Graves JD, Gotoh Y. MST1-JNK promotes apoptosis via caspase-dependent and independent pathways. Genes Cells. 2001, 6:519-530. Wajant H. Death receptors. Essays Biochem. 2003, 39:53-71.
Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T, Smith C, Smolak P, Goodwin RG, Rauch CT, Schuh JC, Lynch DH. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999, 5:157-163.
Wang CY, Mayo MW, Korneluk RG., Goeddel DV, Baldwin AS Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 1998, 281:1680-1683.
Wang J, Chun HJ, Wong W, Spencer DM, Lenardo MJ. Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci USA. 2001, 98:13884-13888.
Wang Q, Ji Y, Wang X, Evers BM. Isolation and molecular characterization of the 5'-upstream region of the human TRAIL gene. Biochem Biophys Res Commun. 2000, 276:466-471.
Wang ZB, Liu YQ, Cui YF. Pathways to caspase activation. Cell Biol Int. 2005, 29:489?496. Weyts FA, Verburg-van Kemenade BM, Flik G. Characterisation of glucocorticoid receptors in peripheral blood leukocytes of carp, Cyprinus carpio L. Gen Comp Endocrinol. 1998, 111:1-8.
Weyts FA, Verburg-van Kemenade BM, Flik G, Lambert JG, Wendelaar Bonga SE. Conservation of apoptosis as an immune regulatory mechanism: effects of cortisol and cortisone on carp lymphocytes. Brain Behav Immun. 1997, 11:95-105.
Widmann C, Gibson S, Jarpe MB, Johnson GL. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev. 1999, 79:143-180.
Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA, Goodwin RG. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995, 3:673-682.
Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner V, Liu H, Daniel TO, Smith CA, Fanslow WC. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity. 2001, 15:837-846.
Wood AW, van der Kraak G. Inhibition of apoptosis in vitellogenic ovarian follicles of rainbow trout (Oncorhynchus mykiss) by salmon gonadotropin, epidermal growth factor, and 17beta-estradiol. Mol Reprod Dev. 2002, 61:511-518.
Yabu T, Kishi S, Okazaki T, Yamashita M. Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo. Biochem J. 2001, 360:39-47.
Yao Z, Zhou G, Wang XS, Brown A, Diener K, Gan H, Tan TH. A novel human STE20- related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J Biol Chem. 1999, 274:2118-2125.
Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT mediated apoptosis. J. Biol. Chem. 1999, 274:13733-13736.
Yuan CQ, Ding ZH. Structure and function of caspases. Guowai Yixue Fenzi Shengwuxue Fence. 2002, 24:146-151.
Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell. 1993, 75:641-652.
Yue TL, Ohlstein EH, Ruffolo RR Jr. Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases. Curr Opin Chem Biol. 1999, 3:474-480.
Zhang YA, Nie P, Luo HY, Wang YP, Sun YH, Zhu ZY. Characterization of cDNA encoding immunoglobulin light chain of the mandarin fish (Siniperca chuatsi). Vet Immunol Immunopathol. 2003, 95:81-90.
Zhang YA, Nie P, Wang YP, Zhu ZY. cDNA sequence encoding immunoglobulin M heavy chain of the mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 2003, 14:477-480.
Zhivotovsky B, Orrenius S. Caspase-2 function in response to DNA damage. Biochem Biophys Res Commun. 2005, 331: 859-867.
Zhou TH, Ling K, Guo J, Zhou H, Wu YL, Jing Q, Ma L, Pei G. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. J Biol Chem. 2000, 275:2513-2519.
Zou J, Wang T, Hirono I, Aoki T, Inagawa H, Honda T, Soma GI, Ototake M, Nakanishi T, Ellis AE, Secombes CJ. Differential expression of two tumor necrosis factor genes in rainbow trout, Oncorhynchus mykiss. Dev Comp Immunol. 2002, 26:161-172.