慢律升冲剂治疗窦性心动过缓的临床疗效观察
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摘要
目的:
观察慢律升冲剂治疗窦性心动过缓的临床疗效,并客观评价其有效性、安全性。为中药复方制剂治疗窦性心动过缓提供有力的证据。
方法:
将符合纳入标准的60例患者随机分为治疗组30例,对照组30例,治疗组予以慢律升冲剂,对照组予以心宝丸。连续治疗4周后对临床症状、静息心率、心电图疗效、24小时最小心率、平均心率进行比较,观察慢律升冲剂对窦性心动过缓的临床疗效,并检验其安全性。
结果:
1.两组疗效比较:
临床症状疗效:治疗组显效率为93.3%,对照组显效率为73.3%,经统计学处理,二者差异显著(P＜0.01)。
心电图疗效:治疗组显效率为90%,对照组显效率为53.3%,二者差异显著(P＜0.01)。
2.心率改善情况比较:无论静息心率还是24小时动态心电图最小心率、平均心率比较治疗组均优于对照组,二者差异显著(P＜0.01)。
3.安全指标测定:治疗组未出现一例不良反应,具有安全、有效、无毒副作用,适合长期口服治疗窦性心动过缓。
结论:
慢律升冲剂采用温阳通脉、益气活血的方法可明显改善窦性心动过缓患者的临床症状。慢律升冲剂可明显提高缓窦性心动过缓患者的静息心率及24小时动态心电图最小心率、平均心率。慢律升冲剂无明显副作用,安全、可靠。
Objective:
To evaluate the clinical therapeutic effectiveness of Man lv sheng granule in treatment of sinus bradycardia(SB),and its seffe-ctiveness and safety objectively.To provide powerful evidence for Chinese herbal medicine compound preparation in treatment of SB.
Method:
Divide the 60 patients randomly according to the standard of the illness into 2 groups:30 patients in the treatment group and 30 in the control group,and use Man lv sheng granule in the treatment group and use Xin bao pill in the control group.The treatment lasted for 4 weeks,clinical symptoms;static breath heart rate,effect of ECG,the smallest heart rate in 24 hours and the average heart rate were compared between after treatment and pretreatment stage.Objectives the clinical therapeutic effectiveness of Man lv sheng granule in treatment of sinus bradycardia(SB),and checks its safety.
Result:
1.Two groups compared
Effect of clinical symptoms:treatment group explicit efficiency: 93.3%and control group explicit efficiency:73.3%.Under the treatment of statistics,the two groups have significant differfence (p＜0.01)
Effect of ECG:treatment group explicit efficiency:90%and control group explicit efficiency:53.3%.Under the treatment of statistics,the two groups have significant difference(p＜0.01)
2.Change of heart rate compared
Whether resting heart rate,24 hours dynamic ECG most small heart rate and the average heart rate compared,treatment group is better than control group,and the two have significant difference (p＜0.01)
3.Safety index determination
There is not a case of adverse reaction in treatment group.So the Man lv sheng granule have the characteristics of safety,effective, nontoxic and side effects,and suitable for long-term oral to treat the SB.
Conclusion:
The Man lv sheng granule which use the method of Warm Yang and Activate Pulse,and benefit qi and activate blood,can improve the clinical symptoms of SB patients,and can improve the patients resting heart rate,24 hours dynamic ECG the most small heart rate and the average heart rate significantly,and have no significant side effects.It is safety and reliable.
观察慢律升冲剂治疗窦性心动过缓的临床疗效,并客观评价其有效性、安全性。为中药复方制剂治疗窦性心动过缓提供有力的证据。
方法:
将符合纳入标准的60例患者随机分为治疗组30例,对照组30例,治疗组予以慢律升冲剂,对照组予以心宝丸。连续治疗4周后对临床症状、静息心率、心电图疗效、24小时最小心率、平均心率进行比较,观察慢律升冲剂对窦性心动过缓的临床疗效,并检验其安全性。
结果:
1.两组疗效比较:
临床症状疗效:治疗组显效率为93.3%,对照组显效率为73.3%,经统计学处理,二者差异显著(P＜0.01)。
心电图疗效:治疗组显效率为90%,对照组显效率为53.3%,二者差异显著(P＜0.01)。
2.心率改善情况比较:无论静息心率还是24小时动态心电图最小心率、平均心率比较治疗组均优于对照组,二者差异显著(P＜0.01)。
3.安全指标测定:治疗组未出现一例不良反应,具有安全、有效、无毒副作用,适合长期口服治疗窦性心动过缓。
结论:
慢律升冲剂采用温阳通脉、益气活血的方法可明显改善窦性心动过缓患者的临床症状。慢律升冲剂可明显提高缓窦性心动过缓患者的静息心率及24小时动态心电图最小心率、平均心率。慢律升冲剂无明显副作用,安全、可靠。
Objective:
To evaluate the clinical therapeutic effectiveness of Man lv sheng granule in treatment of sinus bradycardia(SB),and its seffe-ctiveness and safety objectively.To provide powerful evidence for Chinese herbal medicine compound preparation in treatment of SB.
Method:
Divide the 60 patients randomly according to the standard of the illness into 2 groups:30 patients in the treatment group and 30 in the control group,and use Man lv sheng granule in the treatment group and use Xin bao pill in the control group.The treatment lasted for 4 weeks,clinical symptoms;static breath heart rate,effect of ECG,the smallest heart rate in 24 hours and the average heart rate were compared between after treatment and pretreatment stage.Objectives the clinical therapeutic effectiveness of Man lv sheng granule in treatment of sinus bradycardia(SB),and checks its safety.
Result:
1.Two groups compared
Effect of clinical symptoms:treatment group explicit efficiency: 93.3%and control group explicit efficiency:73.3%.Under the treatment of statistics,the two groups have significant differfence (p＜0.01)
Effect of ECG:treatment group explicit efficiency:90%and control group explicit efficiency:53.3%.Under the treatment of statistics,the two groups have significant difference(p＜0.01)
2.Change of heart rate compared
Whether resting heart rate,24 hours dynamic ECG most small heart rate and the average heart rate compared,treatment group is better than control group,and the two have significant difference (p＜0.01)
3.Safety index determination
There is not a case of adverse reaction in treatment group.So the Man lv sheng granule have the characteristics of safety,effective, nontoxic and side effects,and suitable for long-term oral to treat the SB.
Conclusion:
The Man lv sheng granule which use the method of Warm Yang and Activate Pulse,and benefit qi and activate blood,can improve the clinical symptoms of SB patients,and can improve the patients resting heart rate,24 hours dynamic ECG the most small heart rate and the average heart rate significantly,and have no significant side effects.It is safety and reliable.
引文
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