益气活血、泄热熄风法治疗出血性中风急性期的临床验证研究
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摘要
目的：验证益气活血、泄热熄风法治疗出血性中风急性期的临床疗效,为临床提供疗效确切、使用方便、易于推广的中西医结合治疗方案。
方法：在全国33家医疗单位开展益气活血、泄热熄风法治疗出血性中风的临床研究,采用3：1(治疗组3例,对照组1例,按患者入院顺序)的对照研究方法。治疗组采用益气活血、泄热熄风法方案,即在常规西医治疗基础上,加用具有益气活血、泄热熄风功效的中风醒脑方；对照组采用常规西医治疗。观察患者治疗前后神经功能缺损、血肿吸收率、病死率、中医症状体征严重程度积分等指标的改变,评价治疗7天、14±2天、21±3天、90±5天等时间点患者的情况,同时观察治疗过程中的不良反应。
结果：1.神经功能缺损情况：治疗组在21±3天、90±5天时神经功能缺损改善情况优于对照组,差异有统计学意义(P<0.05)
2.血肿吸收率：21±3天时治疗组血肿吸收率优于对照组,差异有统计学意义(P<0.05)；
3.病死率：治疗21±3天时治疗组和对照组病死率差异无统计学意义；90天时治疗组病死率低于对照组,差异有统计学意义(P<0.05)；
4.中医症状体征改变：治疗7天、14±2天、21±3天治疗组中医症状体征积分改善情况优于对照组,差异有统计学意义(P<0.05)；
5.二组均未出现严重不良反应。
结论：1、益气活血、泄热熄风法治疗方案能改善出血性中风急性期患者神经功能缺损情况,在治疗14±2天、21±3天、90±5天时改善患者的神经功能缺损程度优于单纯西医治疗方案；
2、益气活血、泄热熄风法治疗方案能促进出血性中风急性期患者血肿吸收率,在21±3天时优于单纯西医治疗方案；
3、益气活血、泄热熄风法治疗方案能降低出血性中风急性期患者病死率,在90±5天时疗效优于单纯西医治疗方案；
4、益气活血、泄热熄风法治疗方案较西医对照组在改善症状体征的严重程度积分及对生活的影响程度上优于西医治疗方案。
5、通过此次大样本、多中心临床验证,认为益气活血、泄热熄风法治疗方案疗效确切,是一个安全有效,使用方便,易于临床规范化操作和适合城乡应用的最佳方案。
Objective:To evaluate the effect of "FUYUANXINGNAO" treatment in acute Cerebral hemorrhage.
Objects and Methods:Devided acute cerebral hemorrhage into two groups by ratio of3:1(3cases to the "FUYUANXINGNAO" treatment group and1to contrast group). The "FUYUANXINGNAO" treatment group cured by usual western medicine treatment and traditional Chinese medicine ZHONGFENGXINGNAO prescription, the contrast group cured by usual western medicine treatment only. Observing the patient's fatality, hematoma absorption rate, integration of the influence to life in TCM, integration of the neurologic deficits, evaluating the effectiveness in7days,14days,21days and90days.
Results:Neurologic impairment:the change of the neurologic deficits of the treatment group is superior to the contrast group in14,21days and90days, there is statistical significance in comparison of two groups (P<0.05)
1. Hematoma absorption rate:the absorption rate of hematoma of the treatment group is superior to the contrast group, there is statistical significance in comparison of two groups (P<0.05)
2. Change of the symptoms and physical signs of TCM:the symptoms and physical signs of TCM of the treatment group is superior to the contrast group in7days,14days and21days, there is statistical significance in comparison of two groups (P <0.05);
3. Fatality:There is no statistical significance in fatality of two groups before21days, but there is statistical significance in fatality of two groups after90days' therapy (P<0.05). The fatality of the treatment group is lesser than the contrast group;
4. There is no obvious untoward reaction during the treatment process both of the two groups.
Conclusion:1. The "FUYUANXINGNAO" treatment can reduce the fatality of acute cerebral hemorrhage in90days.
2. The "FUYUANXINGNAO" treatment can promote absorption of hematoma. in21days.
3. The "FUYUANXINGNAO" treatment is superior to the usual western medicine treatment in improving the neurologic deficits in21days and90days.
4. The "FUYUANXINGNAO" treatment is superior to the usual western medicine treatment in integration of symptoms, physical signs and integration of influence to life, especially in hemiplegic paralysis, mouth slanting, stuttering, numbness of limbs, dizziness, fatigue, headache, and so on.
方法：在全国33家医疗单位开展益气活血、泄热熄风法治疗出血性中风的临床研究,采用3：1(治疗组3例,对照组1例,按患者入院顺序)的对照研究方法。治疗组采用益气活血、泄热熄风法方案,即在常规西医治疗基础上,加用具有益气活血、泄热熄风功效的中风醒脑方；对照组采用常规西医治疗。观察患者治疗前后神经功能缺损、血肿吸收率、病死率、中医症状体征严重程度积分等指标的改变,评价治疗7天、14±2天、21±3天、90±5天等时间点患者的情况,同时观察治疗过程中的不良反应。
结果：1.神经功能缺损情况：治疗组在21±3天、90±5天时神经功能缺损改善情况优于对照组,差异有统计学意义(P<0.05)
2.血肿吸收率：21±3天时治疗组血肿吸收率优于对照组,差异有统计学意义(P<0.05)；
3.病死率：治疗21±3天时治疗组和对照组病死率差异无统计学意义；90天时治疗组病死率低于对照组,差异有统计学意义(P<0.05)；
4.中医症状体征改变：治疗7天、14±2天、21±3天治疗组中医症状体征积分改善情况优于对照组,差异有统计学意义(P<0.05)；
5.二组均未出现严重不良反应。
结论：1、益气活血、泄热熄风法治疗方案能改善出血性中风急性期患者神经功能缺损情况,在治疗14±2天、21±3天、90±5天时改善患者的神经功能缺损程度优于单纯西医治疗方案；
2、益气活血、泄热熄风法治疗方案能促进出血性中风急性期患者血肿吸收率,在21±3天时优于单纯西医治疗方案；
3、益气活血、泄热熄风法治疗方案能降低出血性中风急性期患者病死率,在90±5天时疗效优于单纯西医治疗方案；
4、益气活血、泄热熄风法治疗方案较西医对照组在改善症状体征的严重程度积分及对生活的影响程度上优于西医治疗方案。
5、通过此次大样本、多中心临床验证,认为益气活血、泄热熄风法治疗方案疗效确切,是一个安全有效,使用方便,易于临床规范化操作和适合城乡应用的最佳方案。
Objective:To evaluate the effect of "FUYUANXINGNAO" treatment in acute Cerebral hemorrhage.
Objects and Methods:Devided acute cerebral hemorrhage into two groups by ratio of3:1(3cases to the "FUYUANXINGNAO" treatment group and1to contrast group). The "FUYUANXINGNAO" treatment group cured by usual western medicine treatment and traditional Chinese medicine ZHONGFENGXINGNAO prescription, the contrast group cured by usual western medicine treatment only. Observing the patient's fatality, hematoma absorption rate, integration of the influence to life in TCM, integration of the neurologic deficits, evaluating the effectiveness in7days,14days,21days and90days.
Results:Neurologic impairment:the change of the neurologic deficits of the treatment group is superior to the contrast group in14,21days and90days, there is statistical significance in comparison of two groups (P<0.05)
1. Hematoma absorption rate:the absorption rate of hematoma of the treatment group is superior to the contrast group, there is statistical significance in comparison of two groups (P<0.05)
2. Change of the symptoms and physical signs of TCM:the symptoms and physical signs of TCM of the treatment group is superior to the contrast group in7days,14days and21days, there is statistical significance in comparison of two groups (P <0.05);
3. Fatality:There is no statistical significance in fatality of two groups before21days, but there is statistical significance in fatality of two groups after90days' therapy (P<0.05). The fatality of the treatment group is lesser than the contrast group;
4. There is no obvious untoward reaction during the treatment process both of the two groups.
Conclusion:1. The "FUYUANXINGNAO" treatment can reduce the fatality of acute cerebral hemorrhage in90days.
2. The "FUYUANXINGNAO" treatment can promote absorption of hematoma. in21days.
3. The "FUYUANXINGNAO" treatment is superior to the usual western medicine treatment in improving the neurologic deficits in21days and90days.
4. The "FUYUANXINGNAO" treatment is superior to the usual western medicine treatment in integration of symptoms, physical signs and integration of influence to life, especially in hemiplegic paralysis, mouth slanting, stuttering, numbness of limbs, dizziness, fatigue, headache, and so on.
引文
[1]Masada T, Hua Y, Xi G, et al. Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overepression of in terleukilr 1 receptor antagonist[J]. Neurosurgery,2001,95(4):680—686.
[2]Pulsinelli WA, Jacewicz M, Levy DE, et al. Ishemid brain injury and the therapeutic window[J]. Ann NY Acad Sci,1997,835:187-193.
[3]Nakashima K, Yamashita K, Uesugi S, et al. Temporal and spatial pr-ofile of apoptotic cell death in transient intracerebral mass lesion of the rat[J].J Neurorauma,1999,16(2):143—151.
[4]陈建华,宋运田.微创手术与内科保守疗法治疗高血压脑出血疗效分析[J]白求恩医学院学报,2010,8(4)：265-266.
[5]陈绍宏,张晓云.逐瘀化痰口服液治疗急性脑出血的临床及实验研究[J].中国中医急症,1995,4(2)：58.
[6]陈绍宏,唐天俊.逐瘀化痰口服液治疗急性脑出血：附110倒临床疗效分析[J].中国中医急症,1993,2(6)：242.
[7]陈绍宏,张晓云.中风醒脑口服液治疗急性脑出血的临床研究[J].中国中医急症,2004,12(13)：793.
[8]张晓云,陈俊.中风醒脑口服液治疗急性脑出血125例临床疗效分析[J].中国中医急症,2005,8(8)：148.
[9]饶明俐,王文志,黄如训.中国脑血管病防治指南.北京：人民卫生出版社,2005.
[10]国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准(试行).
[11]Jiang B, Wang WZ, Chen H, et al.Incidence and trends of stroke and its subtypes in China:Results from three large eities[J]. Stroke, 2006 Jan,37(1):63-68
[12]Mendelow AD, Gregson BA, Femandes HM, et aL. Early surgery versus initiM conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage:a randomised trial[J]. Lancet,2005 Jan 29 — Feb 4:365; 387-397
[13]Donovan FM, Pike CJ, Cotman CW, et al. Thrombin induces apoptosisin cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci,1997,17(14):5316—5326.
[14]Guo FQ, Yang YS, Song WZ. The effective of nimodipe on region al cerebral blood flow, brain ede ma and cl inical change of dosage at the different time after cerebral hemorrhage. J Clin Neurol,2002, 14(1):6-9.
[15]Gong C, Hoff JT, Keep RF. Acute inflammatory reaction following experimental intracerebral hemorrhage in rat. Brain Res,2000, 871(1):57—65.
[16]Shinton R Beevers G. Meta-analysis of relation between cigarette smoking and stroke. BMJ,1989,298:789—794.
[17]Reynolds K, Lewis B, Nolen JD, et al. Alcohol consumption and risk of stroke:a meta-ananysis. JAMA,2003,289:579—588.
[18]王善娟,初春,3970例脑血管病患者住院情况统计分析[J].中国医院统计,2009,16(3)：283-284
[19]皓晓彬,刘怀军.脑出血、出血性脑梗死、梗死后出血性转化的病例复评及其临床价值探讨[J].河北医科大学影像医学与核医学毕业论文,2010
[20]Bogousslavsky J, Hennerici MG. Stroke scores and scales. Cerebrovascular Diseases,1992,2:239.
[21]张学文.中风病临床研究.陕西中医,1988,(9)：385-387.
[22]张苏明等,脑出血临床研究评价[J].中华神经科杂志,2003,36(4)：245--242
[23]王永炎.中风病科研思路刍议.辽宁中医杂志,1984,(9)：1-5
[24]陈江宁.脑梗死病机之我见[J].江苏中医,2000,21(2)：45.
[25]张根明.缺血性中风病因病机新探[J].中国中医基础医学杂志,2002.8(7)：541.
[26]郭建文,刘明洁,何迎春,等.张景岳辨治中风病学术思想浅识[J].中国中医急症,2003,12(2)：159.
[27]刘冰冰,吴华慧,丁淑霞,等.脑出血的中医治疗进展[J].中国实用医药,2008,3(36)：228-229
[28]龙晓燕,黄国钧.中风醒脑口服液对脑缺血的保护作用[J].药学进展.2000,24(5)：299-301.
[29]黄国钧,龙晓燕,陈绍宏,等.益气活血口服液降低颅内压作用的实验研究[J].中药新药与临床药理.2000,11(4)：219-220.
[30]虢周科,等.益气活血口服液对家兔实验性脑水肿的影响[J].成都中医学院学报.1993,16(1)：37-39.
[31]高学敏.中药学[M].北京：人民卫生出版社,2004：1513-1543.
[1]明.张介宾著夏之秋校注.景岳全书[M].北京：中国中医药出版社,1994,128-130.
[2]刘伍立等.中医文献对中风病的阐述与述评[J].针灸临床杂志,2006,22(10)：5.
[3]清.秦之桢.症因脉治.北京：中国中医药出版社出版,1998年2月第1版.
[4]杨明均.中医辩证施治几个问题的探讨.四川中医,1984,(4)：4-7.
[5]张学文.中风病临床研究.陕西中医,1988,(9)：385-387.
[6]张苏明等,脑出血临床研究评价[J].中华神经科杂志,2003,36(4)：245—242
[7]涂正凡.血瘀与中风刍议.北京中医学院学报,1989,(2)：27-30.
[8]陈黎明.略论衰老的血瘀机制与出血性中风的治疗.云南中医杂志,1993,(6)：4-7.
[9]沈宝藩.中风病临床经验.陕西中医,1989,(9)：388-342.
[10]孙西庆.熄风化痰通络法治疗中风病的研究.山东中医学院学报,1989,(1)：17-20.
[11]焦树德.中风病的诊治和预防.新中医,1997,29(9)：6-10.
[12]王永炎.中风病科研思路刍议.辽宁中医杂志,1984,(9)：1-5.
[13]黄世敬,尹颖辉,王永炎.论“虚气流滞”.北京中医学院学报,1996,(6)：22-23.
[14]王立新,出血性中风急性期病因病机探讨.中医研究,2001年2月,第14卷,第1期：36
[15]顾金隆,中风病血瘀证的临床辨治.甘肃中医2003年,第16卷第17期：12
[16]陈更等,用“治血四法”探讨出血性中风的治疗.《甘肃中医》1995年第8卷第6期：21
[17]郭会军等,出血性脑中风病因病机的探讨.中医研究,1999年10月,第12卷,第5期：12
[18]郑强.脑血疏通口服液治疗出血性中风的临床研究[J].中国实验方剂学杂志,2001,6(7)：58-59.
[19]杨继文,袁曙光,多慧玲.补阳还五汤治疗中小量出血性中风30例临床观察[J].河北中医,2004,26(11)：841-842.
[20]李莹莹.补阳还五汤加减治疗中风偏瘫患者50例疗效观察[J].辽宁中医杂志,2007,34(6)：774-775.
[21]方顺淼.大黄在中风急症中的应用.江西中医药,2004,2(2)：54.
[22]丁元庆.中风病痰热腑实证辨治规律探讨.山西中医,2001；17(6)：12-13.
[23]王玉珊.通腑泻热法治疗脑出血急性期44例临床观察.河南中医,1998；19
[24]常富业,王永炎.中风病毒邪论.北京中医药大学学报,2004(1)：27
[25]王白玲,姜诗谦.大黄在急性脑血管疾病中的应用.实用中医内科杂志,2004,18(4)：337.
[26]周军怀.中西医结合治疗急性期高血压脑出血20例观察[J].中国中西医结合杂志,2009,5(16)：188.
[27]袁园等.凉血通瘀方治疗脑出血的临床研究[J].南京中医药大学学报,2009,7(25)：265.
[28]刘燕.早期运用活血化瘀法治疗出血性中风32例临床观察[J].中医药导报,2009.11(15)：22-23.
[29]吴子辉等.逐瘀安脑丸治疗出血性中风急性期40例疗效观察[J].新中医,2005,2(37)：39.
[30]王冉.通下活血汤治疗急性出血性中风的临床研究[J].辽宁中医杂志,2002,12(29)：738.
[31]袁永萱,郑本德.祛痰开窍法治疗出血性中风伴意识障碍60例.实用中西医结合杂志,1997；10(11)：1080.
[32]丁元庆.中风病痰热腑实证辨治规律探讨.山西中医,2001；17(6)：12-13.
[33]杨利,黄燕,蔡业峰.1418例中风患者痰瘀证候分布和演变规律探析[J].辽宁中医志,2006,31(6)：459-460.
[34]王兵.活血化痰法治疗出血性中风32例[J].辽宁中医杂志,2003,10(30)：824
[35]李贤.中西医结合治疗出血性中风60例疗效观察[J].河北中医,2010,8(32)：1193-1194.
[36]吕莉君,刘忠达,姚纯俭,等.泻热平肝法治疗脑出血急综述性期疗效观察[J].浙江中西医结合杂志,2004,14(5)：296.
[37]葛洪奎.平肝熄风汤治疗脑出血临床观察[J].中医中药,2008,1(5)：160-161
[38]谭勇等.平肝熄风汤对脑出血大鼠海马线粒体膜电位的影响[J].中南大学学报,2004,29(1)：35-37.
[39]刘学芬,李瑞洲.凉血通腑法在脑出血急性期的应用.天津中医学院学报,2002；21(2)：17-18.
[40]赵东萍,高丙峰.凉血逐瘀汤煎剂灌肠治疗急性脑出血临床观察.中国乡村医药杂志,2004：11(7)：38-39.
[41]侯倩.单味大黄在脑出血急性期的应用.青海医药杂志,1996；26(11)：23-24.
[42]郭跃进,梁晖.三七对高血压脑出血颅内血肿吸收的影响.福建中医学院学报,1997；7(2)：8.
[43]许志强.脉血康胶囊治疗脑出血30例临床观察.中医杂志,2000：41(12)：726.
[44]行清椿,张书文.清降调督透刺治疗脑出血75例临床观察[J].中国针灸,1998,18(12)：719
[45]王宏生,于庆麟,窦茶花.独穴分期针刺脑出血急性期66例[J].针灸临床杂志,1997,13(4)：81
[46]郑健刚,周继曾,张存生,等.“醒脑开窍”针法治疗脑出血急性期实验研究[J].天津中医,1996,13(5)：8
[47]邹伟,王汉芳,匡洪宇,等.针刺对脑出血急性期大鼠脑组织L PO和SOD的影响[J]中国中医药科技,1999,6(6)：393
[48]郑谅,周莹,李艳慧,等.针刺对中风血过氧化脂质和抗氧化酶的影响[J].新中医,2001,33(6)：42
[49]郭长娥等.清开灵在脑出血中的应用观察[J].中国民间疗法,2008,(1)：35.
[50]赵耀辉等.清开灵注射液治疗急性期脑出血的临床观察[J].四川医学,2010,4(31)：516.
[51]李秀芹等.疏血通注射液治疗亚急性期脑出血80分析[J].山东医药,2005,45(6)：60.
[52]赵卫等.醒脑静注射液治疗出血性中风意识障碍的疗效观察[J].中国社区医师,2009,12(11)：127.
[53]盂令秋,张淑琴,吴江,等.凝血酶与实验性脑出血后水通道蛋白4表达变化的研究[J].中风与神经疾病杂志,2007,24(3)：298-299.
[54]江汉秋,刘群,刘瑾,等凝血酶对大鼠脑内MMP-9、MMP-2表达的影响[J].中风与神经疾病杂志,2006,23(2)：75-77.
[55]周中和,王景周,曲方,等.凝血酶对大鼠脑出血血肿周围组织的毒性损伤研究[J].中国临床神经科学,2004,12(1)：16-19.
[56]Guan JX. Sun SG. Cao XB. et al. Effect of thrombin on blood brainbarrier permeability and its mechanism. Chin Med J(Engl),2004,117:1677-1681.
[57]张文武,急诊内科学.第二版[M]：919-920.
[58]冉春风.脑血管疾病[M].北京：科学技术出版社,2000：243—293
[59]Ritter MA, Droste DW, Hegedus K, et al. Role of cerebral amyloid angiopathy in intracerebral hemorrhage in hypertensive patients[J]. Neurology,2005, 64(7): 1233 — 1237
[60]陈志,邢学民.脑出血治疗现状.国外医学脑血管疾病分册,2004,12(4)：241—250
[55]Xiaoying W,Tatsuro M, Toshihisa S, et al. Hemoglobin-Induced Cytotoxicity in Rat Cerebral Cortical Neurons. Stroke,2002,33:1882.
[56]Mayer S A. Intracerebral hemorrhage:natural history andrationale of ultra-early hemostatic therapy. Intensive CareMed,2002,28:S235-S240.
[63]Brott T, Broderick J, Kothari R, et al. EarlY hemorrhage growth in patients with intracerebral hemorrhage [J]. Stroke,1997,28(1):1-5.
[64]Zauzui AR, Diringer MN, Derdeyn CP, et al. Progression of mass effect after intracerebral hemorrhage [J]. Stroke,1999,30:1167-1173
[65]FujiiY, TakeuchiS, Sasaki0, et al. Mult ivariate analysis of predietors of hemot-oma enlargement in spomtaneous intracerebral hemorrhage[J]. Stroke,1998, 29(5):1160—1166
[66]Siddique MS, Femandes HM. Wooldridge TD, et al. Reversible is-chemia around intracerebral hemorrhage:a single-photon emission computerized tomography study[J]. J Neurosurg,2002,96(4):736-741.
[67]Dong Q, Ding HY, Shi LF, et al. Study of regional cerebral blood flow around hematoma in acute intraeerebral hemorrhage by xenon-CT [J]. Zhonghua Yi Xue Za Zhi,2004,84(10):822-825.
[68]Schellinger PD, Fiebach JB, Hoffmann K, et al. Stoke MRI in in-tracerebral hemorrhage:is there a perihemorrhagic penumbra [J]. Stroke,2003,34(7): 1674 · 1679.
[69]Xue M, Del Biqio MR. lntracerebral Injection of autologous whole blood in rats time course of inflammation and celldeath[J]. Neurosci Lett,2000,283(3): 230-232.
[70]Xue M, Del Biqio MR. Intracortical hemOrrh ge injury in rats:relationship between blood fractiongs and brain cell death [J] strok,2000,31 (7):1721-1727.
[71]Mayne M, Ni W. Yan HJ, et al. Antisense oligodeoxy nucleotide inhibition of tumor necrosis factor-a exoression is neuropro — tective after intracerebral hemorrhage [J]. stroke.2001,32 (1):240-248.
[72]Siddique MS, Femandes HM. Wooldridge TD, et al. Reversible is-chemia around intracerebral hemorrhage:a single-photon emission computerized tomography study [J]. J Neurosurg,2002,96(4):736-741.
[73]Dziedzic T, Bartus S, Klimkowicz A, et al. Intracerebral hemorrhage triggers interleukin-6 and interleukin.10 release in blood [J]. Stroke,2002,33(9): 2334-2335.
[74]Di Napoli M, Papa F, Bocola V. Prognostic influence of in-creased C-reactive protein and f ibrinogen levels in ischemic stroke [J]. Stroke,2001,32 (1):133-138.
[75]蓝业平等.高血压脑出血患者C—反应蛋白含量变化及其临床意义[J].广东医学,2010,31(10)：1313-1314.
[76]Peeling J,Del Bigio MR, Corbett D,et al. Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide(NXY-059). a free radical trapping agent, in a rat model of hemorrhagic stroke. Neuropharmacology,2001,40(3):433-439.
[77]Peeling J, Yan HJ, Chen SG, et al. Protective effects of free radical inhibitors in intracerebral hemorrhage in rat. Brain Res,1998,795(1-2):63-70.
[78]ROman GC, Erkinjantti T, Wallin A, et al. Subcortical is chaemi cvascular dementia[J]. Lancet Neural,2002,1(7):426-436.
[79]Bhasin RR, Xi G, Hua Y, et al. Experimental intracerebral hemorrhage:effect of lysed erythrocytes on brain edema and blood-brain barrier permeability [J]. Acta Neurochir Suppl,2002,81:249-251.
[80]Wagner KR, Packard BA, Hall CL. et al. Protein oxidation and heme oxygenase-1 induction in porcine white matter following in-tracerebral infusions of whole blood or plasma [J]. Dev Neurosci,2002,24(2/3):154-160.
[81]侯雪湄,杨金升.脑出血与细胞凋亡[J].国外医学.脑血管疾病分册,2005.13(5)374-377.
[82]Ayala Y, Cantwell AM, Rose T, et al. Molecular mapping of throm-Bin-receptor interactions [J]. Proteins,2001,45(2):107-116.
[83]盂令秋,张淑琴,吴江,等.凝血酶与实验性脑出血后水通道蛋白4表达变化的研究[J].中风与神经疾病杂志,2007,24(3)：298-299.
[84]江汉秋,刘群,刘瑾,等凝血酶对大鼠脑内MMP-9、MMP-2表达的影响[J].中风与神经疾病杂志,2006,23(2)：75-77.
[85]周中和,王景周,曲方,等.凝血酶对大鼠脑出血血肿周围组织的毒性损伤研究[J].中国临床神经科学,2004,12(1)：16-19.
[86]Guan JX. Sun SG. Cao XB. et al. Effect of thrombin on blood brainbarrier permeability and its mechanism. Chin Med J(Engl),2004,117:1677-1681.
[87]Nakamura T, Xi G, Park JW, et al. Holo transferrin and thrombin can interact to cause Brain Damage. Stroke,2005,36:348-352.
[88]李红杰等.出血性中风凝血机制变化规律研究[J].中风与神经疾病志,2007,24(5)：593.
[89]Qureshi AI, Suri MF, Ostrow PT, et al. Apoptosis as a form of celldeath in intracerebral hemorrhage[J]. Neurosurgery,2003,52:1041-1048.
[90]AI, Tuhram S, Broderick JP, et al. Spontaneous intracerebral hemorrhage. N Engl J Med,2001,344:1450-1460.
[91]Witt KA, Mark KS.Huber J, et al.Hypoxia—inducible factor nuclear factor kappa-B activation in blood-brain barier endothelium under hypoxic/reoxygenation stress. J Neurochem,2005,92:203-214.
[92]吴成翰,严晓华,丁喜艳,等.脑出血患者血肿周围神经元凋 亡及相关调控基因的观察[J].中华医学杂志,2006,86：3073-3076.
[93]刘欣,黄作义,王夏新,等.大鼠脑出血周边组织NO含量和活性变化对细胞凋亡的影响[J].黑龙江医药科学,2004,27(3)：1-3.
[94]Broderick JP, Adams HP Jr, Barsan W, Feinberg W, Feldmann E, Grotta J, Kase C, Krieger D, Mayberg M, Tilley B, Zabramski JM, Zuccarello M. Guidelines for the management of spontaneous intracerebral hemorrhage:a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke.1999; 30:905-915.
[95]Italian Acute Stroke Study Group. Haemodilution in acute stroke:results of the Italian haemodilution trial. Lancet.1988; 1:318-321.
[96]Yu YL, Kumana CR, Lauder IJ, Cheung YK, Chan FL, Kou M, Chang CM, Cheung RT, Fong KY. Treatment of acute cerebral hemorrhage with intravenous glycerol:a double-blind, placebo-controlled, randomized trial. Stroke.1992; 23: 967-971.
[97]Poungvarin N, Bhoopat W, Viriyavejakul A, Rodprasert P, Buranasiri P, Sukondhabhant S, Hensley MJ, Strom BL. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. N Engl J Med.1987; 316:1229-1233.
[98]Tellez H, Bauer RB. Dexamethasone as treatment in cerebrovascular disease,1: a controlled study in intracerebral hemorrhage. Stroke.1973; 4:541-546.
[99]Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, Spilker J, Duldner J, Khoury J. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke.1997; 28:1-5.
[100]Mayer SA, Brun NC, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T; Europe/AustralAsia NovoSeven ICH Trial Investigators. Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage. Stroke.2005; 36:74-79.
[101]Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med.2005; 352:777-785.
[102]Gebel JM, Brott TG, Sila CA, Tomsick TA, Jauch E, Salisbury S, Khoury J, Miller R, Pancioli A, Duldner JE, Topol EJ, Broderick JP. Decreased perihematomal edema in thrombolysis-related intracerebral hemorrhage compared with spontaneous intracerebral hemorrhage. Stroke.2000; 31:596-600.
[103]Wagner KR, Xi G, Hua Y, Kleinholz M, de Courten-Myers GM, Myers RE, Broderick JP, Brott TG. Lobar intracerebral hemorrhage model in pigs:rapid edema development in perihematomal white matter. Stroke.1996; 27:490-497.
[104]Xi G, Wagner KR, Keep RF, Hua Y, de Courten-Myers GM, Broderick JP, Brott TG, Hoff JT, Muizelaar JP. Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. Stroke.1998; 29:2580-2586.
[105]Roberts HR, Monroe DM, White GC. The use of recombinant factor VIIa in the treatment of bleeding disorders [published correction appears in Blood. 2005:105:2257]. Blood.2004; 104:3858-3864.
[106]Hedner U. Mechanism of action of factor VIIa in the treatment of coagulopathies. Semin Thromb Hemost.2006; 32 (suppl 1):77-85.
[107]Mayer SA, Brun NC, Broderick J, Davis SM, Diringer MN, Skolnick BE, Steiner T; United States NovoSeven ICH Trial Investigators. Recombinant activated factor Ⅶ for acute intracerebral hemorrhage:US phase IIA trial. Neurocrit Care.2006; 4:206-214.
[108]Freeman WD, Brott TG, Barrett KM, Castillo PR, Deen HG Jr, Czervionke LF, Meschia JF. Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage. Mayo Clin Proc.2004; 79: 1495-1500.
[109]Brody DL, Aiyagari V, Shackleford AM, Diringer MN. Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhage. Neurocrit Care.2005; 2:263-267.
[110]Deveras RA, Kessler CM. Reversal of warfarin-induced excessive anticoagulation with recombinant human factor VIIa concentrate. Ann Intern Med.2002; 137:884-888.
[111]李强.重组活化凝血因子Ⅷ超早期治疗脑出血的临床疗效观察及其抗细胞凋亡作用的研究.第二军医大学学位论文.2006.6-32.
[112]Charo IF, Taubman MB. Chemokines in the pathogenesis of vascular disease. Circ Res2004,95(3):858-866.
[113]Qureshi AI, Bliwise DL. Rate of 24-hour blood presure decline and mortality after spontaneous intracerebral hemorrhage:a retrospective analysis with a random effects regression model. Crit Med,1999,27(3):480-485.
[114]Devin L, Brown, Lewis B. Stopping the Bleeding in intracerebral hemorrhage. N Engl J Med,2005,352(8):828-830.
[115]Powers WJ, Zazulia AR, Videen TO, Adams RE, Yundt KD, Aiyagari V, Grubb RL Jr, Diringer MN. Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage. Neurology.2001; 57:18-24.
[116]Misra UK, Kalita J, Ranjan P, Mandal SK. Mannitol in intracerebral hemorrhage: a randomized controlled study. J Neurol Sci.2005; 234:41-45.
[117]Qureshi AI, Wilson DA, Hanley DF, Traystman RJ. Pharmacologic reduction of mean arterial pressure does not adversely affect regional cerebral blood flow and intracranial pressure in experimental intracerebral hemorrhage. Crit Care Med.1999; 27:965-971.
[118]Kidwell CS, Saver JL, Mattiello J, Warach S, Liebeskind DS, Starkman S, Vespa PM, Villablanca JP, Martin NA, Frazee J, Alger JR. Diffusion-perfusion MR evaluation of perihematomal injury in hyperacute intracerebral hemorrhage. Neurology.2001; 57:1611-1617.
[119]Kazui S, Minematsu K, Yamamoto H, Sawada T, Yamaguchi T. Predisposing factors to enlargement of spontaneous intracerebral hematoma. Stroke.1997; 28: 2370-2375.
[120]Qureshi AI, Mohammad YM, Yahia AM, Suarez JI, Siddiqui AM, Kirmani JF, Suri MF, Kolb J, Zaidat 00. A prospective multicenter study to evaluate the feasibility and safety of aggressive antihypertensive treatment in patients with acute intracerebral hemorrhage. J Intensive Care Med.2005; 20:34-42.
[121]Broderick JP, Diringer MN, Hill MD, Brun NC, Mayer SA, Steiner T, Skolnick BE, Davis SM; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Determinants of intracerebral hemorrhage growth:an exploratory analysis. Stroke.2007; 38:1072-1075.
[122]Jauch EC, Lindsell CJ, Adeoye 0, Khoury J, Barsan W, Broderick J, Pancioli A, Brott T. Lack of evidence for an association between hemodynamic variables and hematoma growth in spontaneous intracerebral hemorrhage. Stroke.2006; 37: 2061-2065.
[123]Ohwaki K, Yano E, Nagashima H, Hirata M, Nakagomi T, Tamura A. Blood pressure management in acute intracerebral hemorrhage:relationship between elevated blood pressure and hematoma enlargement. Stroke.2004; 35:1364-1367.
[124]Qureshi AI, Bliwise DL, Bliwise NG, Akbar MS, Uzen G, Frankel MR. Rate of 24-hour blood pressure decline and mortality after spontaneous intracerebral hemorrhage:a retrospective analysis with a random effects regression model. Crit Care Med.1999; 27:480-485.
[125]Vespa P. What is the optimal threshold for cerebral perfusion pressure following traumatic brain injury. Neurosurg Focus.2003; 15:E4. Review.
[126]Robertson CS, Valadka AB, Hannay HJ, Contant CF, Gopinath SP, Cormio M, Uzura M, Grossman RG. Prevention of secondary ischemic insults after severe head injury. Crit Care Med.1999; 27:2086-2095.
[127]Chambers IR, Banister K, Mendelow AD. Intracranial pressure within a developing intracerebral haemorrhage. Br J Neurosurg.2001; 15:140-141.
[128]Fernandes HM, Siddique S, Banister K, Chambers I, Wooldridge T, Gregson B, Mendelow AD. Continuous monitoring of ICP and CPP following ICH and its relationship to clinical, radiological and surgical parameters. Acta Neurochir Suppl.2000; 76:463-466.
[129]Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V. Measurements of acute cerebral infarction: a clinical examination scale. Stroke.1989; 20:864-870.
[130]Teasdale G, Jennett B. Assessment of coma and impaired consciousness:a practical scale. Lancet.1974; 2:81-84.
[131]Diringer MN, Edwards DF. Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage. Crit Care Med.2001; 29:635-640.
[132]Dunn LT. Raised intracranial pressure. J Neurol Neurosurg Psychiatry.2002; 73 (suppl 1):123-127.
[133]Lundberg N. Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiatr Scand Suppl.1960:36:1-193.
[134]Rosner MJ. Introduction to cerebral perfusion pressure management. Neurosurg Clin N Am.1995; 6:761-773.
[135]Rosner MJ, Daughton S. Cerebral perfusion pressure management in head injury. J Trauma.1990; 30:933-940.
[136]Oertel M, Kelly DF, Lee JH, Glenn TC, Vespa PM, Martin NA. Is CPP therapy beneficial for all patients with high ICP? Acta Neurochir Suppl.2002; 81: 67-68.
[137]Nirula R, Gentilello LM. Detrimental effects of hypothermia. In:Tisherman SA, Sterz F, eds. Therapeutic Hypothermia. New York, NY:Springer; 2005: 235-251.
[138]Steiner T, Friede T, Aschoff A, Schellinger PD, Schwab S, Hacke W. Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery. Stroke.2001; 32:2833-2835.
[139]Adams RE, Diringer MN. Response to external ventricular drainage in spontaneous intracerebral hemorrhage with hydrocephalus. Neurology.1998; 50: 519-523.
[140]Schade RP, Schinkel J, Visser LG, Van Dijk JM, Voormolen JH, Kuijper EJ. Bacterial meningitis caused by the use of ventricular or lumbar cerebrospinal fluid catheters. J Neurosurg.2005; 102:229-234.
[141]Lozier AP, Sciacca RR, Romagnoli MF, Connolly ES Jr. Ventriculostomy-related infections:a critical review of the literature. Neurosurgery.2002; 51: 170-181.
[142]Halloway KL, Barnes T, Choi S, Bullock R, Marshall LF, Eisenberg HM, Jane JA, Ward JD, Young HF, Marmarou A. Ventricolostomy infections:the effect of monitoring duration and catheter exchange in 584 patients. J Neurosurg.1996; 85:419-424.
[143]Diringer MN, Zazulia AR. Osmotic therapy:fact and fiction. Neurocrit Care. 2004; 1:219-233.
[144]Qureshi AI, Suarez JI. Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit Care Med.2000; 28: 3301-3313.
[145]Kontos HA, Raper AJ, Patterson JL. Analysis of vasoactivity of local pH, PC02 and bicarbonate on pial vessels. Stroke.1977; 8:358-360.
[146]Stocchetti N, Maas AI, Chieregato A, van der Plas AA. Hyperventilation in head injury:a review. Chest.2005; 127:1812-1827.
[147]Schwab S, Spranger M, Schwarz S, Hacke W. Barbiturate coma in severe hemispheric stroke:useful or obsolete? Neurology.1997; 48:1608-1613.
[148]Fogelholm R, Murros K, Rissanen A, Avikainen S. Admission blood glucose and short term survival in primary intracerebral haemorrhage:a population based study. J Neurol Neurosurg Psychiatry.2005; 76:349-353.
[149]Demchuk AM, Morgenstern LB, Krieger DW, Linda Chi T, Hu W, Wein TH, Hardy RJ, Grotta JC, Buchan AM. Serum glucose level and diabetes predict tissue plasminogen activator-related intracerebral hemorrhage in acute ischemic stroke. Stroke.1999; 30:34-39.
[150]Weir CJ, Murray GD, Dyker AG, Lees KR. Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long-term follow up study. BMJ.1997; 314:1303-1306.
[151]Adams HP Jr, Adams RJ, Brott T, del Zoppo GJ, Furlan A, Goldstein LB, Grubb RL, Higashida R, Kidwell C, Kwiatkowski TG, Marler JR, Hademenos GJ; Stroke Council of the American Stroke Association. Guidelines for the early management of patients with ischemic stroke:a scientific statement from the Stroke Council of the American Stroke Association. Stroke.2003; 34:1056-1083.
[152] http://www.rcplondon.ac.uk/pubs/contents/9c4488ac-d8fl-43d8-b9da-b801441bcdfb.p df
[153]Passero S, Rocchi R, Rossi S, Ulivelli M, Vatti G. Seizures after spontaneous supratentorial intracerebral hemorrhage. Epilepsia.2002; 43:1175-1180.
[154]Vespa PM,0'Phelan K, Shah M, Mirabelli J, Starkman S, Kidwell C, Saver J, Nuwer MR, Frazee JG, McArthur DA, Martin NA. Acute seizures after intracerebral hemorrhage:a factor in progressive midline shift and outcome. Neurology.2003; 60:1441-1446.
[155]Meierkord H, Boon P, Engelsen B, Gocke K, Shorvon S, Tinuper P, Holtkamp M. EFNS guideline on the management of status epilepticus. Eur J Neurol.2006; 13:445-450.
[156]Krieger DW, Yenari MA. Therapeutic hypothermia for acute ischemic stroke:what do laboratory studies teach us? Stroke.2004; 35:1482-1489.
[157]Kawai N, Nakamura T, Okauchi M, Nagao S. Effects of hypothermia on intracranial hemodynamics and ischemic brain damage:studies in the rat acute subdural hematoma model. Acta Neurochir Suppl.2000; 76:529-533.
[158]Kawai N, Nakamura T, Okauchi M, Nagao S. Effects of hypothermia on intracranial pressure and brain edema formation:studies in a rat acute subdural hematoma model. J Neurotrauma.2000; 17:193-202.
[159]MacLellan C, Shuaib A, Colbourne F. Failure of delayed and prolonged hypothermia to favorably affect hemorrhagic stroke in rats. Brain Res.2002; 958:192-200.
[160]Schwarz S, Hafner K, Aschoff A, Schwab S. Incidence and prognostic significance of fever following intracerebral hemorrhage. Neurology.2000; 54:354-361.
[161]Rossi S, Zanier ER, Mauri I, Columbo A, Stocchetti N. Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage. J Neurol Neurosurg Psychiatry.2001; 71:448-454.
[162]Gupta R, Jovin TG, Krieger DW. Therapeutic hypothermia for stroke:do new outfits change an old friend. Expert Rev Neurother.2005; 5:235-246.
[163]Schwab S, Georgiadis D, Berrouschot J, Schellinger PD, Graffagnino C, Mayer SA. Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke.2001; 32:2033-2035.
[164]Joint Royal Colleges Ambulance Liaison Committee and Ambulance Service Association. UK Ambulance Ambulance Service Clinical Practice Guideline(2006). London:ASA,2006.
[165]Joint Royal Colleges Ambulance Liaison Committee and Ambulance Service Association. UK Ambulance Ambulance Service Clinical Practice Guideline(2006). London:ASA,2006.
[166]Ronning OM, Guldvog B. Should stroke victims routinely receive supplemental oxygen? A quasi-randomized controlled trial. Stroke,1999,30:2033-2037.
[167]Chiu EU,Liu CS,Tan TY, et al. Venturi mask adjuvant oxygen therapy in severe acute ischemic stroke.Arch Neurol,2006,63:741-744.
[168]Intensive anti-hypertensive treatment may control blood clot after stroke.http://www.strokeassociation.org/presenter.jhtml?identifier=3053940
[169]Haley EC, Thompson JL, Levin B, et al. Gavestinel does not improve outcome after acute intracerebral hemorrhage:an analysis from the GAIN International and GAIN Americas studies. Stroke,2005,36:1006-1010.
[170]Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema for mation following intracerebral hemorrhage in rats.J Neurosurg.1998; 89(6):991.
[171]Secades JJ, Alvarez-Sabin J, Rubio F, et al. Citicoline in intracerebral haemorrhage:a double-blind,randomized, placebo-controlled, multi-centre pilot study.Cerebrovasc Dis,2006,21:380-385.
[172]丁宏岩,董强.自由基清除剂依达拉奉对脑缺血的治疗作用.国外医学：脑血管疾病分册,2004；12(7)491-493.
[173]丁朝兵,陈东,周易谦.急性高血压性脑出血抗自由基治疗临床研究.脑与神经疾病杂志.2006：14(6)：427-428.
[174]李凤仙,方建.依达拉奉治疗急性脑出血的临床分析.中国实用神经疾病杂志.2007；10(2)：130-131.
[175]刘娟,姚国恩,蒋晓江,等.自由基清除剂依达拉奉治疗脑出血36例疗效观察.重庆医学.2007；36(13)：1257-1258.
[176]陆磊,孙晓江,张进,等.自由基清除剂在急性脑出血的应用研究.中国急救医学.2007；27(5)：448-451.
[177]薛春水薛村水,李光来,贺杰峰,等.大鼠脑出血后神经干细胞移植的实验研究.中西医结合心脑血管病杂志,2004,2(5)：283-285.
[178]Jeong SW,Chu K, Jung KH. Human Neural Stem Cell Transplantation Promotes Functional Recover in Rats with Experimental Intracerebral Hemorrhage. Stroke,2003,34(9):2258.
[179]Guzman R, De A, Choo K, et al. Intracarotid delivery of CD94d FACS sorted neural stem cells enchances angiogenesis and improves functional outcome after experimental stroke,2008,39:540.
[180]张朋奇,姜晓兵,朱贤立,等.同种异体神经干细胞移植治疗大鼠脑内出血的研究Central China Medical Journal,2005,29(2):116-118.
[181]FricKer RA, Carpenter MIi, Winklerl C, et al. ration and neuronal differentiation of human neural progenitior cells after transplantation in the adult rat brain.science,1999,19:5990-6005.
[182]Honmou 0, Houkin K, Waxman SG, et al. Intravenous transplantation of autologous mesenchymal stem cells derived from bone marrow into stroke patients. Stroke,2008,39:532.
[183]杨清成,梁长春,李敏霞等.神经十细胞移植治疗脑卒中后遗症59例.中国阻止工程研究与临床康复.2007,11(20)：4033-4035.
[184]庄锦屏,张玉芳.行神经干细胞移植的脑出血偏瘫患者的康复护理.康复护理,11(21)：1948-1849.
[185]吴家华,罗焕敏.神经干细胞移植治疗中枢神经系统疾病可行性研究.中国老年医学杂志,2005,1(25)：110-113.)。
[186]Fraser DG, Moody AR, Morgan PS, Martel AL, Davidson I. Diagnosis of lower-limb deep vein thrombosis:a prospective blinded study of magnetic resonance direct thrombus imaging. Ann Intern Med.2002; 136:89-98.
[187]Lacut K, Bressollette L, Le Gal G, Etienne E, De Tinteniac A, Renault.A, Rouhart F, Besson G, Garcia JF, Mottier D, Oger E; VICTORIAh (Venous Intermittent Compression and Thrombosis Occurrence Related to Intra-cerebral Acute hemorrhage) Investigators. Prevention of venous thrombosis in patients with acute intracerebral hemorrhage. Neurology.2005; 65:865-869.
[188]Boeer A, Voth E, Henze T, Prange HW. Early heparin therapy in patients with spontaneous intracerebral haemorrhage. J Neurol Neurosurg Psychiatry.1991; 54:466-467.
[189]Decousus H, Leizorovicz A, Parent F, Page Y, Tardy B, Girard P, Laporte S, Faivre R, Charbonnier B, Barral FG, Huet Y, Simonneau G; Prevention du Risque d'Embolie Pulmonaire par Interruption Cave Study Group. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. N Engl J Med.1998; 338:409-415.
[190]Kelly.J, Hunt BJ, Lewis RR, Rudd A. Anticoagulation or inferior vena cava filter placement for patients with primary intracerebral hemorrhage developing venous thromboembolism? Stroke.2003; 34:2999-3005.
[191]Chapman N, Huxley R, Anderson C, Bousser MG, Chalmers J, Colman S, Davis S, Donnan G, MacMahon S, Neal B, Warlow C, Woodward M. Effects of a perindopril-based blood pressure-lowering regimen on the risk of recurrent stroke according to stroke subtype and medical history:the PROGRESS Trial. Stroke.2004; 35:116-121.
[192]Hart RG, Tonarelli SB, Pearce LA. Avoiding central nervous system bleeding during antithrombotic therapy:recent data and ideas. Stroke.2005; 36: 1588-1593.
[193]Juvela S, Heiskanen 0, Poranen A, Valtonen S, Kuurne T, Kaste M, Troupp H. The treatment of spontaneous intracerebral hemorrhage:a prospective randomized trial of surgical and conservative treatment. J Neurosurg.1989; 70:755-758.
[194]Zuccarello M, Brott T, Derex L, Kothari R, Sauerbeck L, Tew J, Van Loveren H, Yeh HS, Tomsick T, Pancioli A, Khoury J, Broderick J. Early surgical treatment for supratentorial intracerebral hemorrhage:a randomized feasibility study. Stroke.1999; 30:1833-1839.
[195]Mendelow AD, Gregson BA, Fernandes HM, Murray GD, Teasdale GM, Hope DT, Karimi A, Shaw MD, Barer DH. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH):a randomised trial. Lancet.2005; 365:387-397.
[196]Van Loon J, Van Calenbergh F, Goff in J, Plets C. Controversies in the management of spontaneous cerebellar haemorrhage:a consecutive series of 49 cases and review of the literature. Acta Neurochir (Wien).1993; 122:187-193.
[197]Firsching R, Huber M, Frowein RA. Cerebellar haemorrhage:management and prognosis. Neurosurg Rev.1991; 14:191-194.
[198]Da Pian R, Bazzan A, Pasqualin A. Surgical versus medical treatment of spontaneous posterior fossa haematomas:a cooperative study on 205 cases. Neurol Res.1984; 6:145-151.
[199]Kase C. Cerebellar hemorrhage. In:Kase CS, Caplan LR, eds. Intracerebral Hemorrhage. Boston, Mass:Butterworth-Heinemann; 1994:425-443.
[200]Sypert G, Arpin-Sypert E. Spontaneous posterior fossa hematomas. In:Kaufman H, ed. Intracerebral Hematomas. New York, NY:Raven Press; 1992:187-196.
[201]Morioka J, Fujii M, Kato S, Fujisawa H, Akimura T, Suzuki M, Kobayashi S. Surgery for spontaneous intracerebral hemorrhage has greater remedial value than conservative therapy. Surg Neurol.2006; 65:67-72.
[202]Kirollos RW, Tyagi AK, Ross SA, van Hille PT, Marks PV. Management of spontaneous cerebellar hematomas:a prospective treatment protocol. Neurosurgery.2001; 49:1378-1386.
[203]Mohadjer M, Braus DF, Myers A, Scheremet R, Krauss JK. CT-stereotactic fibrinolysis of spontaneous intracerebral hematomas. Neurosurg Rev.1992; 15: 105-110.
[204]Niizuma H, Shimizu Y, Yonemitsu T, Nakasato N, Suzuki J. Results of stereotactic aspiration in 175 cases of putaminal hemorrhage. Neurosurgery. 1989; 24:814-819.
[205]Auer LM, Deinsberger W, Niederkorn K, Gell G, Kleinert R, Schneider G, Holzer P, Bone G, Mokry M, Korner E, Kleinert G, Hanusch S. Endoscopic surgery versus medical treatment for spontaneous intracerebral hematoma:a randomized study. J Neurosurg.1989; 70:530-535.
[206]Broderick JP, Brott T, Zuccarello M. Management of intracerebral hemorrhage. In:Batjer HH, ed. Cerebrovascular Disease. Philadelphia, Pa:Lippincott-Raven; 1997:611-627.
[207]Kanaya H, Kuroda K. Development in neurosurgical approaches to hypertensive intracerebral hemorrhage in Japan. In:Kaufman HH, ed. Intracerebral Hematomas. New York, NY:Raven Press; 1992:197-210.
[208]Kaufman HH. Stereotactic aspiration with fibrinolytic and mechanical assistance. In:Kaufman HH, ed. Intracerebral Hematoma. New York, NY:Raven Press; 1992:182-185.
[209]Fujii Y, Tanaka R, Takeuchi S, Koike T, Minakawa T, Sasaki 0. Hematoma enlargement in spontaneous intracerebral hemorrhage. J Neurosurg.1994; 80: 51-57.
[210]Niizuma H, Yonemitsu T, Jokura H, Nakasato N, Suzuki J, Yoshimoto T. Stereotactic aspiration of thalamic hematoma:overall results of 75 aspirated and 70 nonaspirated cases. Stereotact Funct Neurosurg.1990; 54-55:438-444.
[211]Teernstra OP, Evers SM, Lodder J, et al. Stereotactic treatment of intracerebral hematoma by means of a plasminogen activator:a multicenter randomized controlled trial (SICHPA). Stroke,2003,34:968-974.
[212]Rohde V, Schaller C, Hassler WE. Intraventricular recombinant tissue plasminogen activator for lysis of intraventricular haemorrhage. J Neurol Neurosurg Psychiatry.1995; 58:447-451.
[213]Findlay JM, Grace MG, Weir BK. Treatment of intraventricular hemorrhage with tissue plasminogen activator. Neurosurgery.1993; 32:941-947.
[214]Mayfrank L, Lippitz B, Groth M, Bertalanffy H, Gilsbach JM. Effect of recombinant tissue plasminogen activator on clot lysis and ventricular dilatation in the treatment of severe intraventricular haemorrhage. Acta Neurochir (Wien).1993; 122:32-38.
[215]Schwarz S, Schwab S, Steiner HH, Hacke W. Secondary hemorrhage after intraventricular fibrinolysis:a cautionary note:a report of two cases. Neurosurgery.1998; 42:659-662.
[216]Naff N.T, Hanley DF, Keyl PM, Tuhrim S, Kraut M, Bederson J, Bullock R, Mayer SA, Schmutzhard E. Intraventricular thrombolysis speeds blood clot resolution: results of a pilot, prospective, randomized, double-blind, controlled trial. Neurosurgery.2004; 54:577-583.
[217]Vespa P, McArthur D, Miller C,O'Phelan K, Frazee J, Kidwell C, Saver J, Starkman S, Martin N. Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduction of hemorrhage volume and neurological improvement. Neurocrit Care.2005; 2:274-281.
[218]Backlund EO, von Holst H. Controlled subtotal evacuation of intracerebral haematomas by stereotactic technique. Surg Neurol.1978; 9:99-101.
[219]Kandel El, Peresedov VV. Stereotaxic evacuation of spontaneous intracerebral hematomas. J Neurosurg.1985; 62:206-213.
[220]Higgins AC, Nashold BS Jr. Stereotactic evacuation of large intracerebral hematoma. Appl Neurophysiol.1980; 43:96-103.
[221]Pan DH-C, Lee L-S, Chen M-S, Manns AG. Modified screw-and-suction technique for stereotactic evacuation of deep intracerebral hematomas. Surg Neurol.1986; 25:540-544.
[222]Donauer E, Faubert C. Management of spontaneous intracerebral and cerebellar hemorrhage. In:Kaufman HH, ed. Intracerebral Hematomas. New York, NY:Raven Press; 1992:211-227.
[223]Kaufman HH. Treatment of deep spontaneous intracerebral hematomas:a review. Stroke.1993; 24 (suppl):1-101-1-106.
[224]Nguyen JP, Decq P, Brugieres P, Yepes C, Melon E, Gaston A, Keravel Y. A technique for stereotactic aspiration of deep intracerebral hematomas under computed tomographic control using a new device. Neurosurgery.1992; 31: 330-334.
[225]Tanikawa T, Amano K, Kawamura H, Kawabatake H, Notani M, Iseki H, Shiwaku T, Nagao T, Iwata Y, Taira T, Umezawa Y, Shimizu T, Kitamura K. CT-guided stereotactic surgery for evacuation of hypertensive intracerebral hematoma. Appl Neurophysiol.1985; 48:431-439.
[226]Niizuma H, Suzuki J. Stereotactic aspiration of putaminal hemorrhage using a double track aspiration technique. Neurosurgery.1988; 22:432-436.
[227]Fernandes HM, Gregson B, Siddique S, Mendelow AD. Surgery in intracerebral hemorrhage:the uncertainty continues. Stroke.2000; 31:2511-2516.
[228]Kaneko M, Tanaka K, Shimada T, Sato K, Uemura K. Long-term evaluation of ultra-early operation for hypertensive intracerebral hemorrhage in 100 cases. J Neurosurg.1983; 58:838-842.
[229]Morgenstern LB, Demchuk AM, Kim DH, Frankowski RF, Grotta JC. Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage. Neurology.2001; 56:1294-1299.
[230]Brown DL, Morgenstern LB. Stopping the bleeding in intracerebral hemorrhage. N Engl J Med.2005; 352:828-830.
[231]Tan SH, Ng PY, Yeo TT, Wong SH, Ong PL, Venketasubramanian N. Hypertensive basal ganglia hemorrhage:a prospective study comparing surgical and nonsurgical management. Surg Neurol.2001; 56:287-292.
[232]Murthy JM, Chowdary GV, Murthy TV, Bhasha PS, Naryanan TJ. Decompressive craniectomy with clot evacuation in large hemispheric hypertensive intracerebral hemorrhage. Neurocrit Care.2005; 2:258-262.
[233]杨友松.国内外脑出血基础研究及治疗现状和今后发展的方向.临床内科杂志.2007,24(6)：366.
[234]National Service Framework for the Elderly) (Department of Health. National Service Framework for Older People. London:DH,2001.
[235]Ronning OM, Guldvog B, Stavem K, The benefit of an acute stroke unit in patients with intracranial haemorrhage:a controlled trail. J Neurol Neurosurg Psychiatry,2001,70:631-634.
[236]Stroke Unit Trialists'Collaboration.Organised inpatient(stroke unit)care of stroke. Cochrane Datebase Syst Rev,2007, (4):CD000197.
[237]Qureshi AI,Suri MF, Ostrow PT,et al. Apoptosis as a from of cell death in intracerebral hemorrhage. J Neurosurg,2000,92:1016.
[238]Vermeer SE, Algra A, Franke CL, et al. Long-term prognosis after recovery from primary intracerebral hemorrhage. Neurology.2002; 59:205-209.
[239]Woo D,Haverbusch M, Sekar P, et al. Effect of untreated hypertension on hemorrhagic stroke. Stroke,2004,35:1703-1708.
[240]Perry HM Jr, Davis BR,Price TR, et al. Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke:the Systolic Hypertension in the Elderly Program(SHEP). JAMA,2000,284:464-471.
[241]Kurth T, Kase CS, Berger K, et al. Smoking and the risk of hemorrhagic stroke in men.Stroke,2003,34:1151-1155.
[242]Kurth T,Kase CS,Berger K,et al. Smoking and risk of hemorrhagic stroke in women.Stroke,2003,34:2792-2795.
[243]Iso H, Baba S,Mannami T, et al.Alcohol consumption and risk of stroke among middle-aged men:the JPHC Study Conhort I. Stroke,2004,35:1124-1129.
[244]Thrift AG, Donnan GA, McNeil JJ. Heavy drinking but not moderate or intermediate drinking, increases the risk of intracerebral hemorrhage. Epidemiology,1999,10:307-312.
[245]Feldmann E, Broderick JP, Kernan WN, et al. Major risk factors for intracerebral hemorrhage in the young are modifiable. Stroke,2005,36:1881-1885
[2]Pulsinelli WA, Jacewicz M, Levy DE, et al. Ishemid brain injury and the therapeutic window[J]. Ann NY Acad Sci,1997,835:187-193.
[3]Nakashima K, Yamashita K, Uesugi S, et al. Temporal and spatial pr-ofile of apoptotic cell death in transient intracerebral mass lesion of the rat[J].J Neurorauma,1999,16(2):143—151.
[4]陈建华,宋运田.微创手术与内科保守疗法治疗高血压脑出血疗效分析[J]白求恩医学院学报,2010,8(4)：265-266.
[5]陈绍宏,张晓云.逐瘀化痰口服液治疗急性脑出血的临床及实验研究[J].中国中医急症,1995,4(2)：58.
[6]陈绍宏,唐天俊.逐瘀化痰口服液治疗急性脑出血：附110倒临床疗效分析[J].中国中医急症,1993,2(6)：242.
[7]陈绍宏,张晓云.中风醒脑口服液治疗急性脑出血的临床研究[J].中国中医急症,2004,12(13)：793.
[8]张晓云,陈俊.中风醒脑口服液治疗急性脑出血125例临床疗效分析[J].中国中医急症,2005,8(8)：148.
[9]饶明俐,王文志,黄如训.中国脑血管病防治指南.北京：人民卫生出版社,2005.
[10]国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准(试行).
[11]Jiang B, Wang WZ, Chen H, et al.Incidence and trends of stroke and its subtypes in China:Results from three large eities[J]. Stroke, 2006 Jan,37(1):63-68
[12]Mendelow AD, Gregson BA, Femandes HM, et aL. Early surgery versus initiM conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage:a randomised trial[J]. Lancet,2005 Jan 29 — Feb 4:365; 387-397
[13]Donovan FM, Pike CJ, Cotman CW, et al. Thrombin induces apoptosisin cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci,1997,17(14):5316—5326.
[14]Guo FQ, Yang YS, Song WZ. The effective of nimodipe on region al cerebral blood flow, brain ede ma and cl inical change of dosage at the different time after cerebral hemorrhage. J Clin Neurol,2002, 14(1):6-9.
[15]Gong C, Hoff JT, Keep RF. Acute inflammatory reaction following experimental intracerebral hemorrhage in rat. Brain Res,2000, 871(1):57—65.
[16]Shinton R Beevers G. Meta-analysis of relation between cigarette smoking and stroke. BMJ,1989,298:789—794.
[17]Reynolds K, Lewis B, Nolen JD, et al. Alcohol consumption and risk of stroke:a meta-ananysis. JAMA,2003,289:579—588.
[18]王善娟,初春,3970例脑血管病患者住院情况统计分析[J].中国医院统计,2009,16(3)：283-284
[19]皓晓彬,刘怀军.脑出血、出血性脑梗死、梗死后出血性转化的病例复评及其临床价值探讨[J].河北医科大学影像医学与核医学毕业论文,2010
[20]Bogousslavsky J, Hennerici MG. Stroke scores and scales. Cerebrovascular Diseases,1992,2:239.
[21]张学文.中风病临床研究.陕西中医,1988,(9)：385-387.
[22]张苏明等,脑出血临床研究评价[J].中华神经科杂志,2003,36(4)：245--242
[23]王永炎.中风病科研思路刍议.辽宁中医杂志,1984,(9)：1-5
[24]陈江宁.脑梗死病机之我见[J].江苏中医,2000,21(2)：45.
[25]张根明.缺血性中风病因病机新探[J].中国中医基础医学杂志,2002.8(7)：541.
[26]郭建文,刘明洁,何迎春,等.张景岳辨治中风病学术思想浅识[J].中国中医急症,2003,12(2)：159.
[27]刘冰冰,吴华慧,丁淑霞,等.脑出血的中医治疗进展[J].中国实用医药,2008,3(36)：228-229
[28]龙晓燕,黄国钧.中风醒脑口服液对脑缺血的保护作用[J].药学进展.2000,24(5)：299-301.
[29]黄国钧,龙晓燕,陈绍宏,等.益气活血口服液降低颅内压作用的实验研究[J].中药新药与临床药理.2000,11(4)：219-220.
[30]虢周科,等.益气活血口服液对家兔实验性脑水肿的影响[J].成都中医学院学报.1993,16(1)：37-39.
[31]高学敏.中药学[M].北京：人民卫生出版社,2004：1513-1543.
[1]明.张介宾著夏之秋校注.景岳全书[M].北京：中国中医药出版社,1994,128-130.
[2]刘伍立等.中医文献对中风病的阐述与述评[J].针灸临床杂志,2006,22(10)：5.
[3]清.秦之桢.症因脉治.北京：中国中医药出版社出版,1998年2月第1版.
[4]杨明均.中医辩证施治几个问题的探讨.四川中医,1984,(4)：4-7.
[5]张学文.中风病临床研究.陕西中医,1988,(9)：385-387.
[6]张苏明等,脑出血临床研究评价[J].中华神经科杂志,2003,36(4)：245—242
[7]涂正凡.血瘀与中风刍议.北京中医学院学报,1989,(2)：27-30.
[8]陈黎明.略论衰老的血瘀机制与出血性中风的治疗.云南中医杂志,1993,(6)：4-7.
[9]沈宝藩.中风病临床经验.陕西中医,1989,(9)：388-342.
[10]孙西庆.熄风化痰通络法治疗中风病的研究.山东中医学院学报,1989,(1)：17-20.
[11]焦树德.中风病的诊治和预防.新中医,1997,29(9)：6-10.
[12]王永炎.中风病科研思路刍议.辽宁中医杂志,1984,(9)：1-5.
[13]黄世敬,尹颖辉,王永炎.论“虚气流滞”.北京中医学院学报,1996,(6)：22-23.
[14]王立新,出血性中风急性期病因病机探讨.中医研究,2001年2月,第14卷,第1期：36
[15]顾金隆,中风病血瘀证的临床辨治.甘肃中医2003年,第16卷第17期：12
[16]陈更等,用“治血四法”探讨出血性中风的治疗.《甘肃中医》1995年第8卷第6期：21
[17]郭会军等,出血性脑中风病因病机的探讨.中医研究,1999年10月,第12卷,第5期：12
[18]郑强.脑血疏通口服液治疗出血性中风的临床研究[J].中国实验方剂学杂志,2001,6(7)：58-59.
[19]杨继文,袁曙光,多慧玲.补阳还五汤治疗中小量出血性中风30例临床观察[J].河北中医,2004,26(11)：841-842.
[20]李莹莹.补阳还五汤加减治疗中风偏瘫患者50例疗效观察[J].辽宁中医杂志,2007,34(6)：774-775.
[21]方顺淼.大黄在中风急症中的应用.江西中医药,2004,2(2)：54.
[22]丁元庆.中风病痰热腑实证辨治规律探讨.山西中医,2001；17(6)：12-13.
[23]王玉珊.通腑泻热法治疗脑出血急性期44例临床观察.河南中医,1998；19
[24]常富业,王永炎.中风病毒邪论.北京中医药大学学报,2004(1)：27
[25]王白玲,姜诗谦.大黄在急性脑血管疾病中的应用.实用中医内科杂志,2004,18(4)：337.
[26]周军怀.中西医结合治疗急性期高血压脑出血20例观察[J].中国中西医结合杂志,2009,5(16)：188.
[27]袁园等.凉血通瘀方治疗脑出血的临床研究[J].南京中医药大学学报,2009,7(25)：265.
[28]刘燕.早期运用活血化瘀法治疗出血性中风32例临床观察[J].中医药导报,2009.11(15)：22-23.
[29]吴子辉等.逐瘀安脑丸治疗出血性中风急性期40例疗效观察[J].新中医,2005,2(37)：39.
[30]王冉.通下活血汤治疗急性出血性中风的临床研究[J].辽宁中医杂志,2002,12(29)：738.
[31]袁永萱,郑本德.祛痰开窍法治疗出血性中风伴意识障碍60例.实用中西医结合杂志,1997；10(11)：1080.
[32]丁元庆.中风病痰热腑实证辨治规律探讨.山西中医,2001；17(6)：12-13.
[33]杨利,黄燕,蔡业峰.1418例中风患者痰瘀证候分布和演变规律探析[J].辽宁中医志,2006,31(6)：459-460.
[34]王兵.活血化痰法治疗出血性中风32例[J].辽宁中医杂志,2003,10(30)：824
[35]李贤.中西医结合治疗出血性中风60例疗效观察[J].河北中医,2010,8(32)：1193-1194.
[36]吕莉君,刘忠达,姚纯俭,等.泻热平肝法治疗脑出血急综述性期疗效观察[J].浙江中西医结合杂志,2004,14(5)：296.
[37]葛洪奎.平肝熄风汤治疗脑出血临床观察[J].中医中药,2008,1(5)：160-161
[38]谭勇等.平肝熄风汤对脑出血大鼠海马线粒体膜电位的影响[J].中南大学学报,2004,29(1)：35-37.
[39]刘学芬,李瑞洲.凉血通腑法在脑出血急性期的应用.天津中医学院学报,2002；21(2)：17-18.
[40]赵东萍,高丙峰.凉血逐瘀汤煎剂灌肠治疗急性脑出血临床观察.中国乡村医药杂志,2004：11(7)：38-39.
[41]侯倩.单味大黄在脑出血急性期的应用.青海医药杂志,1996；26(11)：23-24.
[42]郭跃进,梁晖.三七对高血压脑出血颅内血肿吸收的影响.福建中医学院学报,1997；7(2)：8.
[43]许志强.脉血康胶囊治疗脑出血30例临床观察.中医杂志,2000：41(12)：726.
[44]行清椿,张书文.清降调督透刺治疗脑出血75例临床观察[J].中国针灸,1998,18(12)：719
[45]王宏生,于庆麟,窦茶花.独穴分期针刺脑出血急性期66例[J].针灸临床杂志,1997,13(4)：81
[46]郑健刚,周继曾,张存生,等.“醒脑开窍”针法治疗脑出血急性期实验研究[J].天津中医,1996,13(5)：8
[47]邹伟,王汉芳,匡洪宇,等.针刺对脑出血急性期大鼠脑组织L PO和SOD的影响[J]中国中医药科技,1999,6(6)：393
[48]郑谅,周莹,李艳慧,等.针刺对中风血过氧化脂质和抗氧化酶的影响[J].新中医,2001,33(6)：42
[49]郭长娥等.清开灵在脑出血中的应用观察[J].中国民间疗法,2008,(1)：35.
[50]赵耀辉等.清开灵注射液治疗急性期脑出血的临床观察[J].四川医学,2010,4(31)：516.
[51]李秀芹等.疏血通注射液治疗亚急性期脑出血80分析[J].山东医药,2005,45(6)：60.
[52]赵卫等.醒脑静注射液治疗出血性中风意识障碍的疗效观察[J].中国社区医师,2009,12(11)：127.
[53]盂令秋,张淑琴,吴江,等.凝血酶与实验性脑出血后水通道蛋白4表达变化的研究[J].中风与神经疾病杂志,2007,24(3)：298-299.
[54]江汉秋,刘群,刘瑾,等凝血酶对大鼠脑内MMP-9、MMP-2表达的影响[J].中风与神经疾病杂志,2006,23(2)：75-77.
[55]周中和,王景周,曲方,等.凝血酶对大鼠脑出血血肿周围组织的毒性损伤研究[J].中国临床神经科学,2004,12(1)：16-19.
[56]Guan JX. Sun SG. Cao XB. et al. Effect of thrombin on blood brainbarrier permeability and its mechanism. Chin Med J(Engl),2004,117:1677-1681.
[57]张文武,急诊内科学.第二版[M]：919-920.
[58]冉春风.脑血管疾病[M].北京：科学技术出版社,2000：243—293
[59]Ritter MA, Droste DW, Hegedus K, et al. Role of cerebral amyloid angiopathy in intracerebral hemorrhage in hypertensive patients[J]. Neurology,2005, 64(7): 1233 — 1237
[60]陈志,邢学民.脑出血治疗现状.国外医学脑血管疾病分册,2004,12(4)：241—250
[55]Xiaoying W,Tatsuro M, Toshihisa S, et al. Hemoglobin-Induced Cytotoxicity in Rat Cerebral Cortical Neurons. Stroke,2002,33:1882.
[56]Mayer S A. Intracerebral hemorrhage:natural history andrationale of ultra-early hemostatic therapy. Intensive CareMed,2002,28:S235-S240.
[63]Brott T, Broderick J, Kothari R, et al. EarlY hemorrhage growth in patients with intracerebral hemorrhage [J]. Stroke,1997,28(1):1-5.
[64]Zauzui AR, Diringer MN, Derdeyn CP, et al. Progression of mass effect after intracerebral hemorrhage [J]. Stroke,1999,30:1167-1173
[65]FujiiY, TakeuchiS, Sasaki0, et al. Mult ivariate analysis of predietors of hemot-oma enlargement in spomtaneous intracerebral hemorrhage[J]. Stroke,1998, 29(5):1160—1166
[66]Siddique MS, Femandes HM. Wooldridge TD, et al. Reversible is-chemia around intracerebral hemorrhage:a single-photon emission computerized tomography study[J]. J Neurosurg,2002,96(4):736-741.
[67]Dong Q, Ding HY, Shi LF, et al. Study of regional cerebral blood flow around hematoma in acute intraeerebral hemorrhage by xenon-CT [J]. Zhonghua Yi Xue Za Zhi,2004,84(10):822-825.
[68]Schellinger PD, Fiebach JB, Hoffmann K, et al. Stoke MRI in in-tracerebral hemorrhage:is there a perihemorrhagic penumbra [J]. Stroke,2003,34(7): 1674 · 1679.
[69]Xue M, Del Biqio MR. lntracerebral Injection of autologous whole blood in rats time course of inflammation and celldeath[J]. Neurosci Lett,2000,283(3): 230-232.
[70]Xue M, Del Biqio MR. Intracortical hemOrrh ge injury in rats:relationship between blood fractiongs and brain cell death [J] strok,2000,31 (7):1721-1727.
[71]Mayne M, Ni W. Yan HJ, et al. Antisense oligodeoxy nucleotide inhibition of tumor necrosis factor-a exoression is neuropro — tective after intracerebral hemorrhage [J]. stroke.2001,32 (1):240-248.
[72]Siddique MS, Femandes HM. Wooldridge TD, et al. Reversible is-chemia around intracerebral hemorrhage:a single-photon emission computerized tomography study [J]. J Neurosurg,2002,96(4):736-741.
[73]Dziedzic T, Bartus S, Klimkowicz A, et al. Intracerebral hemorrhage triggers interleukin-6 and interleukin.10 release in blood [J]. Stroke,2002,33(9): 2334-2335.
[74]Di Napoli M, Papa F, Bocola V. Prognostic influence of in-creased C-reactive protein and f ibrinogen levels in ischemic stroke [J]. Stroke,2001,32 (1):133-138.
[75]蓝业平等.高血压脑出血患者C—反应蛋白含量变化及其临床意义[J].广东医学,2010,31(10)：1313-1314.
[76]Peeling J,Del Bigio MR, Corbett D,et al. Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide(NXY-059). a free radical trapping agent, in a rat model of hemorrhagic stroke. Neuropharmacology,2001,40(3):433-439.
[77]Peeling J, Yan HJ, Chen SG, et al. Protective effects of free radical inhibitors in intracerebral hemorrhage in rat. Brain Res,1998,795(1-2):63-70.
[78]ROman GC, Erkinjantti T, Wallin A, et al. Subcortical is chaemi cvascular dementia[J]. Lancet Neural,2002,1(7):426-436.
[79]Bhasin RR, Xi G, Hua Y, et al. Experimental intracerebral hemorrhage:effect of lysed erythrocytes on brain edema and blood-brain barrier permeability [J]. Acta Neurochir Suppl,2002,81:249-251.
[80]Wagner KR, Packard BA, Hall CL. et al. Protein oxidation and heme oxygenase-1 induction in porcine white matter following in-tracerebral infusions of whole blood or plasma [J]. Dev Neurosci,2002,24(2/3):154-160.
[81]侯雪湄,杨金升.脑出血与细胞凋亡[J].国外医学.脑血管疾病分册,2005.13(5)374-377.
[82]Ayala Y, Cantwell AM, Rose T, et al. Molecular mapping of throm-Bin-receptor interactions [J]. Proteins,2001,45(2):107-116.
[83]盂令秋,张淑琴,吴江,等.凝血酶与实验性脑出血后水通道蛋白4表达变化的研究[J].中风与神经疾病杂志,2007,24(3)：298-299.
[84]江汉秋,刘群,刘瑾,等凝血酶对大鼠脑内MMP-9、MMP-2表达的影响[J].中风与神经疾病杂志,2006,23(2)：75-77.
[85]周中和,王景周,曲方,等.凝血酶对大鼠脑出血血肿周围组织的毒性损伤研究[J].中国临床神经科学,2004,12(1)：16-19.
[86]Guan JX. Sun SG. Cao XB. et al. Effect of thrombin on blood brainbarrier permeability and its mechanism. Chin Med J(Engl),2004,117:1677-1681.
[87]Nakamura T, Xi G, Park JW, et al. Holo transferrin and thrombin can interact to cause Brain Damage. Stroke,2005,36:348-352.
[88]李红杰等.出血性中风凝血机制变化规律研究[J].中风与神经疾病志,2007,24(5)：593.
[89]Qureshi AI, Suri MF, Ostrow PT, et al. Apoptosis as a form of celldeath in intracerebral hemorrhage[J]. Neurosurgery,2003,52:1041-1048.
[90]AI, Tuhram S, Broderick JP, et al. Spontaneous intracerebral hemorrhage. N Engl J Med,2001,344:1450-1460.
[91]Witt KA, Mark KS.Huber J, et al.Hypoxia—inducible factor nuclear factor kappa-B activation in blood-brain barier endothelium under hypoxic/reoxygenation stress. J Neurochem,2005,92:203-214.
[92]吴成翰,严晓华,丁喜艳,等.脑出血患者血肿周围神经元凋 亡及相关调控基因的观察[J].中华医学杂志,2006,86：3073-3076.
[93]刘欣,黄作义,王夏新,等.大鼠脑出血周边组织NO含量和活性变化对细胞凋亡的影响[J].黑龙江医药科学,2004,27(3)：1-3.
[94]Broderick JP, Adams HP Jr, Barsan W, Feinberg W, Feldmann E, Grotta J, Kase C, Krieger D, Mayberg M, Tilley B, Zabramski JM, Zuccarello M. Guidelines for the management of spontaneous intracerebral hemorrhage:a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke.1999; 30:905-915.
[95]Italian Acute Stroke Study Group. Haemodilution in acute stroke:results of the Italian haemodilution trial. Lancet.1988; 1:318-321.
[96]Yu YL, Kumana CR, Lauder IJ, Cheung YK, Chan FL, Kou M, Chang CM, Cheung RT, Fong KY. Treatment of acute cerebral hemorrhage with intravenous glycerol:a double-blind, placebo-controlled, randomized trial. Stroke.1992; 23: 967-971.
[97]Poungvarin N, Bhoopat W, Viriyavejakul A, Rodprasert P, Buranasiri P, Sukondhabhant S, Hensley MJ, Strom BL. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. N Engl J Med.1987; 316:1229-1233.
[98]Tellez H, Bauer RB. Dexamethasone as treatment in cerebrovascular disease,1: a controlled study in intracerebral hemorrhage. Stroke.1973; 4:541-546.
[99]Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, Spilker J, Duldner J, Khoury J. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke.1997; 28:1-5.
[100]Mayer SA, Brun NC, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T; Europe/AustralAsia NovoSeven ICH Trial Investigators. Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage. Stroke.2005; 36:74-79.
[101]Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med.2005; 352:777-785.
[102]Gebel JM, Brott TG, Sila CA, Tomsick TA, Jauch E, Salisbury S, Khoury J, Miller R, Pancioli A, Duldner JE, Topol EJ, Broderick JP. Decreased perihematomal edema in thrombolysis-related intracerebral hemorrhage compared with spontaneous intracerebral hemorrhage. Stroke.2000; 31:596-600.
[103]Wagner KR, Xi G, Hua Y, Kleinholz M, de Courten-Myers GM, Myers RE, Broderick JP, Brott TG. Lobar intracerebral hemorrhage model in pigs:rapid edema development in perihematomal white matter. Stroke.1996; 27:490-497.
[104]Xi G, Wagner KR, Keep RF, Hua Y, de Courten-Myers GM, Broderick JP, Brott TG, Hoff JT, Muizelaar JP. Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. Stroke.1998; 29:2580-2586.
[105]Roberts HR, Monroe DM, White GC. The use of recombinant factor VIIa in the treatment of bleeding disorders [published correction appears in Blood. 2005:105:2257]. Blood.2004; 104:3858-3864.
[106]Hedner U. Mechanism of action of factor VIIa in the treatment of coagulopathies. Semin Thromb Hemost.2006; 32 (suppl 1):77-85.
[107]Mayer SA, Brun NC, Broderick J, Davis SM, Diringer MN, Skolnick BE, Steiner T; United States NovoSeven ICH Trial Investigators. Recombinant activated factor Ⅶ for acute intracerebral hemorrhage:US phase IIA trial. Neurocrit Care.2006; 4:206-214.
[108]Freeman WD, Brott TG, Barrett KM, Castillo PR, Deen HG Jr, Czervionke LF, Meschia JF. Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage. Mayo Clin Proc.2004; 79: 1495-1500.
[109]Brody DL, Aiyagari V, Shackleford AM, Diringer MN. Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhage. Neurocrit Care.2005; 2:263-267.
[110]Deveras RA, Kessler CM. Reversal of warfarin-induced excessive anticoagulation with recombinant human factor VIIa concentrate. Ann Intern Med.2002; 137:884-888.
[111]李强.重组活化凝血因子Ⅷ超早期治疗脑出血的临床疗效观察及其抗细胞凋亡作用的研究.第二军医大学学位论文.2006.6-32.
[112]Charo IF, Taubman MB. Chemokines in the pathogenesis of vascular disease. Circ Res2004,95(3):858-866.
[113]Qureshi AI, Bliwise DL. Rate of 24-hour blood presure decline and mortality after spontaneous intracerebral hemorrhage:a retrospective analysis with a random effects regression model. Crit Med,1999,27(3):480-485.
[114]Devin L, Brown, Lewis B. Stopping the Bleeding in intracerebral hemorrhage. N Engl J Med,2005,352(8):828-830.
[115]Powers WJ, Zazulia AR, Videen TO, Adams RE, Yundt KD, Aiyagari V, Grubb RL Jr, Diringer MN. Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage. Neurology.2001; 57:18-24.
[116]Misra UK, Kalita J, Ranjan P, Mandal SK. Mannitol in intracerebral hemorrhage: a randomized controlled study. J Neurol Sci.2005; 234:41-45.
[117]Qureshi AI, Wilson DA, Hanley DF, Traystman RJ. Pharmacologic reduction of mean arterial pressure does not adversely affect regional cerebral blood flow and intracranial pressure in experimental intracerebral hemorrhage. Crit Care Med.1999; 27:965-971.
[118]Kidwell CS, Saver JL, Mattiello J, Warach S, Liebeskind DS, Starkman S, Vespa PM, Villablanca JP, Martin NA, Frazee J, Alger JR. Diffusion-perfusion MR evaluation of perihematomal injury in hyperacute intracerebral hemorrhage. Neurology.2001; 57:1611-1617.
[119]Kazui S, Minematsu K, Yamamoto H, Sawada T, Yamaguchi T. Predisposing factors to enlargement of spontaneous intracerebral hematoma. Stroke.1997; 28: 2370-2375.
[120]Qureshi AI, Mohammad YM, Yahia AM, Suarez JI, Siddiqui AM, Kirmani JF, Suri MF, Kolb J, Zaidat 00. A prospective multicenter study to evaluate the feasibility and safety of aggressive antihypertensive treatment in patients with acute intracerebral hemorrhage. J Intensive Care Med.2005; 20:34-42.
[121]Broderick JP, Diringer MN, Hill MD, Brun NC, Mayer SA, Steiner T, Skolnick BE, Davis SM; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Determinants of intracerebral hemorrhage growth:an exploratory analysis. Stroke.2007; 38:1072-1075.
[122]Jauch EC, Lindsell CJ, Adeoye 0, Khoury J, Barsan W, Broderick J, Pancioli A, Brott T. Lack of evidence for an association between hemodynamic variables and hematoma growth in spontaneous intracerebral hemorrhage. Stroke.2006; 37: 2061-2065.
[123]Ohwaki K, Yano E, Nagashima H, Hirata M, Nakagomi T, Tamura A. Blood pressure management in acute intracerebral hemorrhage:relationship between elevated blood pressure and hematoma enlargement. Stroke.2004; 35:1364-1367.
[124]Qureshi AI, Bliwise DL, Bliwise NG, Akbar MS, Uzen G, Frankel MR. Rate of 24-hour blood pressure decline and mortality after spontaneous intracerebral hemorrhage:a retrospective analysis with a random effects regression model. Crit Care Med.1999; 27:480-485.
[125]Vespa P. What is the optimal threshold for cerebral perfusion pressure following traumatic brain injury. Neurosurg Focus.2003; 15:E4. Review.
[126]Robertson CS, Valadka AB, Hannay HJ, Contant CF, Gopinath SP, Cormio M, Uzura M, Grossman RG. Prevention of secondary ischemic insults after severe head injury. Crit Care Med.1999; 27:2086-2095.
[127]Chambers IR, Banister K, Mendelow AD. Intracranial pressure within a developing intracerebral haemorrhage. Br J Neurosurg.2001; 15:140-141.
[128]Fernandes HM, Siddique S, Banister K, Chambers I, Wooldridge T, Gregson B, Mendelow AD. Continuous monitoring of ICP and CPP following ICH and its relationship to clinical, radiological and surgical parameters. Acta Neurochir Suppl.2000; 76:463-466.
[129]Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V. Measurements of acute cerebral infarction: a clinical examination scale. Stroke.1989; 20:864-870.
[130]Teasdale G, Jennett B. Assessment of coma and impaired consciousness:a practical scale. Lancet.1974; 2:81-84.
[131]Diringer MN, Edwards DF. Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage. Crit Care Med.2001; 29:635-640.
[132]Dunn LT. Raised intracranial pressure. J Neurol Neurosurg Psychiatry.2002; 73 (suppl 1):123-127.
[133]Lundberg N. Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiatr Scand Suppl.1960:36:1-193.
[134]Rosner MJ. Introduction to cerebral perfusion pressure management. Neurosurg Clin N Am.1995; 6:761-773.
[135]Rosner MJ, Daughton S. Cerebral perfusion pressure management in head injury. J Trauma.1990; 30:933-940.
[136]Oertel M, Kelly DF, Lee JH, Glenn TC, Vespa PM, Martin NA. Is CPP therapy beneficial for all patients with high ICP? Acta Neurochir Suppl.2002; 81: 67-68.
[137]Nirula R, Gentilello LM. Detrimental effects of hypothermia. In:Tisherman SA, Sterz F, eds. Therapeutic Hypothermia. New York, NY:Springer; 2005: 235-251.
[138]Steiner T, Friede T, Aschoff A, Schellinger PD, Schwab S, Hacke W. Effect and feasibility of controlled rewarming after moderate hypothermia in stroke patients with malignant infarction of the middle cerebral artery. Stroke.2001; 32:2833-2835.
[139]Adams RE, Diringer MN. Response to external ventricular drainage in spontaneous intracerebral hemorrhage with hydrocephalus. Neurology.1998; 50: 519-523.
[140]Schade RP, Schinkel J, Visser LG, Van Dijk JM, Voormolen JH, Kuijper EJ. Bacterial meningitis caused by the use of ventricular or lumbar cerebrospinal fluid catheters. J Neurosurg.2005; 102:229-234.
[141]Lozier AP, Sciacca RR, Romagnoli MF, Connolly ES Jr. Ventriculostomy-related infections:a critical review of the literature. Neurosurgery.2002; 51: 170-181.
[142]Halloway KL, Barnes T, Choi S, Bullock R, Marshall LF, Eisenberg HM, Jane JA, Ward JD, Young HF, Marmarou A. Ventricolostomy infections:the effect of monitoring duration and catheter exchange in 584 patients. J Neurosurg.1996; 85:419-424.
[143]Diringer MN, Zazulia AR. Osmotic therapy:fact and fiction. Neurocrit Care. 2004; 1:219-233.
[144]Qureshi AI, Suarez JI. Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit Care Med.2000; 28: 3301-3313.
[145]Kontos HA, Raper AJ, Patterson JL. Analysis of vasoactivity of local pH, PC02 and bicarbonate on pial vessels. Stroke.1977; 8:358-360.
[146]Stocchetti N, Maas AI, Chieregato A, van der Plas AA. Hyperventilation in head injury:a review. Chest.2005; 127:1812-1827.
[147]Schwab S, Spranger M, Schwarz S, Hacke W. Barbiturate coma in severe hemispheric stroke:useful or obsolete? Neurology.1997; 48:1608-1613.
[148]Fogelholm R, Murros K, Rissanen A, Avikainen S. Admission blood glucose and short term survival in primary intracerebral haemorrhage:a population based study. J Neurol Neurosurg Psychiatry.2005; 76:349-353.
[149]Demchuk AM, Morgenstern LB, Krieger DW, Linda Chi T, Hu W, Wein TH, Hardy RJ, Grotta JC, Buchan AM. Serum glucose level and diabetes predict tissue plasminogen activator-related intracerebral hemorrhage in acute ischemic stroke. Stroke.1999; 30:34-39.
[150]Weir CJ, Murray GD, Dyker AG, Lees KR. Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long-term follow up study. BMJ.1997; 314:1303-1306.
[151]Adams HP Jr, Adams RJ, Brott T, del Zoppo GJ, Furlan A, Goldstein LB, Grubb RL, Higashida R, Kidwell C, Kwiatkowski TG, Marler JR, Hademenos GJ; Stroke Council of the American Stroke Association. Guidelines for the early management of patients with ischemic stroke:a scientific statement from the Stroke Council of the American Stroke Association. Stroke.2003; 34:1056-1083.
[152] http://www.rcplondon.ac.uk/pubs/contents/9c4488ac-d8fl-43d8-b9da-b801441bcdfb.p df
[153]Passero S, Rocchi R, Rossi S, Ulivelli M, Vatti G. Seizures after spontaneous supratentorial intracerebral hemorrhage. Epilepsia.2002; 43:1175-1180.
[154]Vespa PM,0'Phelan K, Shah M, Mirabelli J, Starkman S, Kidwell C, Saver J, Nuwer MR, Frazee JG, McArthur DA, Martin NA. Acute seizures after intracerebral hemorrhage:a factor in progressive midline shift and outcome. Neurology.2003; 60:1441-1446.
[155]Meierkord H, Boon P, Engelsen B, Gocke K, Shorvon S, Tinuper P, Holtkamp M. EFNS guideline on the management of status epilepticus. Eur J Neurol.2006; 13:445-450.
[156]Krieger DW, Yenari MA. Therapeutic hypothermia for acute ischemic stroke:what do laboratory studies teach us? Stroke.2004; 35:1482-1489.
[157]Kawai N, Nakamura T, Okauchi M, Nagao S. Effects of hypothermia on intracranial hemodynamics and ischemic brain damage:studies in the rat acute subdural hematoma model. Acta Neurochir Suppl.2000; 76:529-533.
[158]Kawai N, Nakamura T, Okauchi M, Nagao S. Effects of hypothermia on intracranial pressure and brain edema formation:studies in a rat acute subdural hematoma model. J Neurotrauma.2000; 17:193-202.
[159]MacLellan C, Shuaib A, Colbourne F. Failure of delayed and prolonged hypothermia to favorably affect hemorrhagic stroke in rats. Brain Res.2002; 958:192-200.
[160]Schwarz S, Hafner K, Aschoff A, Schwab S. Incidence and prognostic significance of fever following intracerebral hemorrhage. Neurology.2000; 54:354-361.
[161]Rossi S, Zanier ER, Mauri I, Columbo A, Stocchetti N. Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage. J Neurol Neurosurg Psychiatry.2001; 71:448-454.
[162]Gupta R, Jovin TG, Krieger DW. Therapeutic hypothermia for stroke:do new outfits change an old friend. Expert Rev Neurother.2005; 5:235-246.
[163]Schwab S, Georgiadis D, Berrouschot J, Schellinger PD, Graffagnino C, Mayer SA. Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke.2001; 32:2033-2035.
[164]Joint Royal Colleges Ambulance Liaison Committee and Ambulance Service Association. UK Ambulance Ambulance Service Clinical Practice Guideline(2006). London:ASA,2006.
[165]Joint Royal Colleges Ambulance Liaison Committee and Ambulance Service Association. UK Ambulance Ambulance Service Clinical Practice Guideline(2006). London:ASA,2006.
[166]Ronning OM, Guldvog B. Should stroke victims routinely receive supplemental oxygen? A quasi-randomized controlled trial. Stroke,1999,30:2033-2037.
[167]Chiu EU,Liu CS,Tan TY, et al. Venturi mask adjuvant oxygen therapy in severe acute ischemic stroke.Arch Neurol,2006,63:741-744.
[168]Intensive anti-hypertensive treatment may control blood clot after stroke.http://www.strokeassociation.org/presenter.jhtml?identifier=3053940
[169]Haley EC, Thompson JL, Levin B, et al. Gavestinel does not improve outcome after acute intracerebral hemorrhage:an analysis from the GAIN International and GAIN Americas studies. Stroke,2005,36:1006-1010.
[170]Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema for mation following intracerebral hemorrhage in rats.J Neurosurg.1998; 89(6):991.
[171]Secades JJ, Alvarez-Sabin J, Rubio F, et al. Citicoline in intracerebral haemorrhage:a double-blind,randomized, placebo-controlled, multi-centre pilot study.Cerebrovasc Dis,2006,21:380-385.
[172]丁宏岩,董强.自由基清除剂依达拉奉对脑缺血的治疗作用.国外医学：脑血管疾病分册,2004；12(7)491-493.
[173]丁朝兵,陈东,周易谦.急性高血压性脑出血抗自由基治疗临床研究.脑与神经疾病杂志.2006：14(6)：427-428.
[174]李凤仙,方建.依达拉奉治疗急性脑出血的临床分析.中国实用神经疾病杂志.2007；10(2)：130-131.
[175]刘娟,姚国恩,蒋晓江,等.自由基清除剂依达拉奉治疗脑出血36例疗效观察.重庆医学.2007；36(13)：1257-1258.
[176]陆磊,孙晓江,张进,等.自由基清除剂在急性脑出血的应用研究.中国急救医学.2007；27(5)：448-451.
[177]薛春水薛村水,李光来,贺杰峰,等.大鼠脑出血后神经干细胞移植的实验研究.中西医结合心脑血管病杂志,2004,2(5)：283-285.
[178]Jeong SW,Chu K, Jung KH. Human Neural Stem Cell Transplantation Promotes Functional Recover in Rats with Experimental Intracerebral Hemorrhage. Stroke,2003,34(9):2258.
[179]Guzman R, De A, Choo K, et al. Intracarotid delivery of CD94d FACS sorted neural stem cells enchances angiogenesis and improves functional outcome after experimental stroke,2008,39:540.
[180]张朋奇,姜晓兵,朱贤立,等.同种异体神经干细胞移植治疗大鼠脑内出血的研究Central China Medical Journal,2005,29(2):116-118.
[181]FricKer RA, Carpenter MIi, Winklerl C, et al. ration and neuronal differentiation of human neural progenitior cells after transplantation in the adult rat brain.science,1999,19:5990-6005.
[182]Honmou 0, Houkin K, Waxman SG, et al. Intravenous transplantation of autologous mesenchymal stem cells derived from bone marrow into stroke patients. Stroke,2008,39:532.
[183]杨清成,梁长春,李敏霞等.神经十细胞移植治疗脑卒中后遗症59例.中国阻止工程研究与临床康复.2007,11(20)：4033-4035.
[184]庄锦屏,张玉芳.行神经干细胞移植的脑出血偏瘫患者的康复护理.康复护理,11(21)：1948-1849.
[185]吴家华,罗焕敏.神经干细胞移植治疗中枢神经系统疾病可行性研究.中国老年医学杂志,2005,1(25)：110-113.)。
[186]Fraser DG, Moody AR, Morgan PS, Martel AL, Davidson I. Diagnosis of lower-limb deep vein thrombosis:a prospective blinded study of magnetic resonance direct thrombus imaging. Ann Intern Med.2002; 136:89-98.
[187]Lacut K, Bressollette L, Le Gal G, Etienne E, De Tinteniac A, Renault.A, Rouhart F, Besson G, Garcia JF, Mottier D, Oger E; VICTORIAh (Venous Intermittent Compression and Thrombosis Occurrence Related to Intra-cerebral Acute hemorrhage) Investigators. Prevention of venous thrombosis in patients with acute intracerebral hemorrhage. Neurology.2005; 65:865-869.
[188]Boeer A, Voth E, Henze T, Prange HW. Early heparin therapy in patients with spontaneous intracerebral haemorrhage. J Neurol Neurosurg Psychiatry.1991; 54:466-467.
[189]Decousus H, Leizorovicz A, Parent F, Page Y, Tardy B, Girard P, Laporte S, Faivre R, Charbonnier B, Barral FG, Huet Y, Simonneau G; Prevention du Risque d'Embolie Pulmonaire par Interruption Cave Study Group. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. N Engl J Med.1998; 338:409-415.
[190]Kelly.J, Hunt BJ, Lewis RR, Rudd A. Anticoagulation or inferior vena cava filter placement for patients with primary intracerebral hemorrhage developing venous thromboembolism? Stroke.2003; 34:2999-3005.
[191]Chapman N, Huxley R, Anderson C, Bousser MG, Chalmers J, Colman S, Davis S, Donnan G, MacMahon S, Neal B, Warlow C, Woodward M. Effects of a perindopril-based blood pressure-lowering regimen on the risk of recurrent stroke according to stroke subtype and medical history:the PROGRESS Trial. Stroke.2004; 35:116-121.
[192]Hart RG, Tonarelli SB, Pearce LA. Avoiding central nervous system bleeding during antithrombotic therapy:recent data and ideas. Stroke.2005; 36: 1588-1593.
[193]Juvela S, Heiskanen 0, Poranen A, Valtonen S, Kuurne T, Kaste M, Troupp H. The treatment of spontaneous intracerebral hemorrhage:a prospective randomized trial of surgical and conservative treatment. J Neurosurg.1989; 70:755-758.
[194]Zuccarello M, Brott T, Derex L, Kothari R, Sauerbeck L, Tew J, Van Loveren H, Yeh HS, Tomsick T, Pancioli A, Khoury J, Broderick J. Early surgical treatment for supratentorial intracerebral hemorrhage:a randomized feasibility study. Stroke.1999; 30:1833-1839.
[195]Mendelow AD, Gregson BA, Fernandes HM, Murray GD, Teasdale GM, Hope DT, Karimi A, Shaw MD, Barer DH. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH):a randomised trial. Lancet.2005; 365:387-397.
[196]Van Loon J, Van Calenbergh F, Goff in J, Plets C. Controversies in the management of spontaneous cerebellar haemorrhage:a consecutive series of 49 cases and review of the literature. Acta Neurochir (Wien).1993; 122:187-193.
[197]Firsching R, Huber M, Frowein RA. Cerebellar haemorrhage:management and prognosis. Neurosurg Rev.1991; 14:191-194.
[198]Da Pian R, Bazzan A, Pasqualin A. Surgical versus medical treatment of spontaneous posterior fossa haematomas:a cooperative study on 205 cases. Neurol Res.1984; 6:145-151.
[199]Kase C. Cerebellar hemorrhage. In:Kase CS, Caplan LR, eds. Intracerebral Hemorrhage. Boston, Mass:Butterworth-Heinemann; 1994:425-443.
[200]Sypert G, Arpin-Sypert E. Spontaneous posterior fossa hematomas. In:Kaufman H, ed. Intracerebral Hematomas. New York, NY:Raven Press; 1992:187-196.
[201]Morioka J, Fujii M, Kato S, Fujisawa H, Akimura T, Suzuki M, Kobayashi S. Surgery for spontaneous intracerebral hemorrhage has greater remedial value than conservative therapy. Surg Neurol.2006; 65:67-72.
[202]Kirollos RW, Tyagi AK, Ross SA, van Hille PT, Marks PV. Management of spontaneous cerebellar hematomas:a prospective treatment protocol. Neurosurgery.2001; 49:1378-1386.
[203]Mohadjer M, Braus DF, Myers A, Scheremet R, Krauss JK. CT-stereotactic fibrinolysis of spontaneous intracerebral hematomas. Neurosurg Rev.1992; 15: 105-110.
[204]Niizuma H, Shimizu Y, Yonemitsu T, Nakasato N, Suzuki J. Results of stereotactic aspiration in 175 cases of putaminal hemorrhage. Neurosurgery. 1989; 24:814-819.
[205]Auer LM, Deinsberger W, Niederkorn K, Gell G, Kleinert R, Schneider G, Holzer P, Bone G, Mokry M, Korner E, Kleinert G, Hanusch S. Endoscopic surgery versus medical treatment for spontaneous intracerebral hematoma:a randomized study. J Neurosurg.1989; 70:530-535.
[206]Broderick JP, Brott T, Zuccarello M. Management of intracerebral hemorrhage. In:Batjer HH, ed. Cerebrovascular Disease. Philadelphia, Pa:Lippincott-Raven; 1997:611-627.
[207]Kanaya H, Kuroda K. Development in neurosurgical approaches to hypertensive intracerebral hemorrhage in Japan. In:Kaufman HH, ed. Intracerebral Hematomas. New York, NY:Raven Press; 1992:197-210.
[208]Kaufman HH. Stereotactic aspiration with fibrinolytic and mechanical assistance. In:Kaufman HH, ed. Intracerebral Hematoma. New York, NY:Raven Press; 1992:182-185.
[209]Fujii Y, Tanaka R, Takeuchi S, Koike T, Minakawa T, Sasaki 0. Hematoma enlargement in spontaneous intracerebral hemorrhage. J Neurosurg.1994; 80: 51-57.
[210]Niizuma H, Yonemitsu T, Jokura H, Nakasato N, Suzuki J, Yoshimoto T. Stereotactic aspiration of thalamic hematoma:overall results of 75 aspirated and 70 nonaspirated cases. Stereotact Funct Neurosurg.1990; 54-55:438-444.
[211]Teernstra OP, Evers SM, Lodder J, et al. Stereotactic treatment of intracerebral hematoma by means of a plasminogen activator:a multicenter randomized controlled trial (SICHPA). Stroke,2003,34:968-974.
[212]Rohde V, Schaller C, Hassler WE. Intraventricular recombinant tissue plasminogen activator for lysis of intraventricular haemorrhage. J Neurol Neurosurg Psychiatry.1995; 58:447-451.
[213]Findlay JM, Grace MG, Weir BK. Treatment of intraventricular hemorrhage with tissue plasminogen activator. Neurosurgery.1993; 32:941-947.
[214]Mayfrank L, Lippitz B, Groth M, Bertalanffy H, Gilsbach JM. Effect of recombinant tissue plasminogen activator on clot lysis and ventricular dilatation in the treatment of severe intraventricular haemorrhage. Acta Neurochir (Wien).1993; 122:32-38.
[215]Schwarz S, Schwab S, Steiner HH, Hacke W. Secondary hemorrhage after intraventricular fibrinolysis:a cautionary note:a report of two cases. Neurosurgery.1998; 42:659-662.
[216]Naff N.T, Hanley DF, Keyl PM, Tuhrim S, Kraut M, Bederson J, Bullock R, Mayer SA, Schmutzhard E. Intraventricular thrombolysis speeds blood clot resolution: results of a pilot, prospective, randomized, double-blind, controlled trial. Neurosurgery.2004; 54:577-583.
[217]Vespa P, McArthur D, Miller C,O'Phelan K, Frazee J, Kidwell C, Saver J, Starkman S, Martin N. Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduction of hemorrhage volume and neurological improvement. Neurocrit Care.2005; 2:274-281.
[218]Backlund EO, von Holst H. Controlled subtotal evacuation of intracerebral haematomas by stereotactic technique. Surg Neurol.1978; 9:99-101.
[219]Kandel El, Peresedov VV. Stereotaxic evacuation of spontaneous intracerebral hematomas. J Neurosurg.1985; 62:206-213.
[220]Higgins AC, Nashold BS Jr. Stereotactic evacuation of large intracerebral hematoma. Appl Neurophysiol.1980; 43:96-103.
[221]Pan DH-C, Lee L-S, Chen M-S, Manns AG. Modified screw-and-suction technique for stereotactic evacuation of deep intracerebral hematomas. Surg Neurol.1986; 25:540-544.
[222]Donauer E, Faubert C. Management of spontaneous intracerebral and cerebellar hemorrhage. In:Kaufman HH, ed. Intracerebral Hematomas. New York, NY:Raven Press; 1992:211-227.
[223]Kaufman HH. Treatment of deep spontaneous intracerebral hematomas:a review. Stroke.1993; 24 (suppl):1-101-1-106.
[224]Nguyen JP, Decq P, Brugieres P, Yepes C, Melon E, Gaston A, Keravel Y. A technique for stereotactic aspiration of deep intracerebral hematomas under computed tomographic control using a new device. Neurosurgery.1992; 31: 330-334.
[225]Tanikawa T, Amano K, Kawamura H, Kawabatake H, Notani M, Iseki H, Shiwaku T, Nagao T, Iwata Y, Taira T, Umezawa Y, Shimizu T, Kitamura K. CT-guided stereotactic surgery for evacuation of hypertensive intracerebral hematoma. Appl Neurophysiol.1985; 48:431-439.
[226]Niizuma H, Suzuki J. Stereotactic aspiration of putaminal hemorrhage using a double track aspiration technique. Neurosurgery.1988; 22:432-436.
[227]Fernandes HM, Gregson B, Siddique S, Mendelow AD. Surgery in intracerebral hemorrhage:the uncertainty continues. Stroke.2000; 31:2511-2516.
[228]Kaneko M, Tanaka K, Shimada T, Sato K, Uemura K. Long-term evaluation of ultra-early operation for hypertensive intracerebral hemorrhage in 100 cases. J Neurosurg.1983; 58:838-842.
[229]Morgenstern LB, Demchuk AM, Kim DH, Frankowski RF, Grotta JC. Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage. Neurology.2001; 56:1294-1299.
[230]Brown DL, Morgenstern LB. Stopping the bleeding in intracerebral hemorrhage. N Engl J Med.2005; 352:828-830.
[231]Tan SH, Ng PY, Yeo TT, Wong SH, Ong PL, Venketasubramanian N. Hypertensive basal ganglia hemorrhage:a prospective study comparing surgical and nonsurgical management. Surg Neurol.2001; 56:287-292.
[232]Murthy JM, Chowdary GV, Murthy TV, Bhasha PS, Naryanan TJ. Decompressive craniectomy with clot evacuation in large hemispheric hypertensive intracerebral hemorrhage. Neurocrit Care.2005; 2:258-262.
[233]杨友松.国内外脑出血基础研究及治疗现状和今后发展的方向.临床内科杂志.2007,24(6)：366.
[234]National Service Framework for the Elderly) (Department of Health. National Service Framework for Older People. London:DH,2001.
[235]Ronning OM, Guldvog B, Stavem K, The benefit of an acute stroke unit in patients with intracranial haemorrhage:a controlled trail. J Neurol Neurosurg Psychiatry,2001,70:631-634.
[236]Stroke Unit Trialists'Collaboration.Organised inpatient(stroke unit)care of stroke. Cochrane Datebase Syst Rev,2007, (4):CD000197.
[237]Qureshi AI,Suri MF, Ostrow PT,et al. Apoptosis as a from of cell death in intracerebral hemorrhage. J Neurosurg,2000,92:1016.
[238]Vermeer SE, Algra A, Franke CL, et al. Long-term prognosis after recovery from primary intracerebral hemorrhage. Neurology.2002; 59:205-209.
[239]Woo D,Haverbusch M, Sekar P, et al. Effect of untreated hypertension on hemorrhagic stroke. Stroke,2004,35:1703-1708.
[240]Perry HM Jr, Davis BR,Price TR, et al. Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke:the Systolic Hypertension in the Elderly Program(SHEP). JAMA,2000,284:464-471.
[241]Kurth T, Kase CS, Berger K, et al. Smoking and the risk of hemorrhagic stroke in men.Stroke,2003,34:1151-1155.
[242]Kurth T,Kase CS,Berger K,et al. Smoking and risk of hemorrhagic stroke in women.Stroke,2003,34:2792-2795.
[243]Iso H, Baba S,Mannami T, et al.Alcohol consumption and risk of stroke among middle-aged men:the JPHC Study Conhort I. Stroke,2004,35:1124-1129.
[244]Thrift AG, Donnan GA, McNeil JJ. Heavy drinking but not moderate or intermediate drinking, increases the risk of intracerebral hemorrhage. Epidemiology,1999,10:307-312.
[245]Feldmann E, Broderick JP, Kernan WN, et al. Major risk factors for intracerebral hemorrhage in the young are modifiable. Stroke,2005,36:1881-1885