小金丸治疗痰湿瘀阻型慢性前列腺炎的临床研究
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摘要
目的:观察小金丸对痰湿瘀阻型慢性前列腺炎疼痛症状、最大尿流率、前列腺液中TNF-α含量的改变情况。
     方法:采用随机、对照的临床试验方法,将76例痰湿瘀阻型慢性前列腺炎患者随机分为两组,每组各38例,治疗组采用小金丸治疗,对照组采用安慰剂治疗,疗程30天,疗效指标为慢性前列腺炎症状指数(NIH-CPSI)疼痛症状评分、最大尿流率及前列腺液中TNF-α含量。
     结果:治疗后治疗组NIH-CPSI疼痛症状评分、最大尿流率、前列腺液中TNF-α含量均有明显改善,对照组对以上指标无明显改变,两组比较差异有统计学意义(P<0.05)。
     结论:小金丸对痰湿瘀阻型慢性前列腺炎疼痛及排尿症状治疗作用明显,是治疗该型前列腺炎的有效药物。
Objective:To observe the effect of Xiaojinwan on NIH-CPSI、Q_(max)、TNF-αin prostatic fluid of Chronic prostatitis with Phlegm,Dampness and Blockage of Blood stasis.
     Methods:With randomized,antithetical clinical trial,76cases were divided into two groups randomly:The treated group had 38 cases treated with Xiaojinwan,The control group had 38 cases treated with placebo,After 30 days,NIH-CPSI、Q_(max)、the content of TNF-αin prostatic fluid were detected.
     Results:After 30 days,the NIH-CPSI、Q_(max)、the content of TNF-αin prostatic fluid of the treated group were all improved notablely,but above-mentioned index of the control group did not improved notablely.There was notablel difference between this two group(P<0.05).
     Conclutions:The effect of Xiaojinwan in treating Chronic prostatitis with Phlegm,Dampness and Blockage of Blood stasis was notable,Xiaojinwan was an effective drug treating this kind of prostatitis.
引文
[1]Moon TD, Hagen L, Heisey DM. Urinary symptomatology in youngermen. Urology, 1997, 50: 700—703
    [2]Roberts RO, Lieber MM, Rhodes T, etal. revalence of a physiciana—ssigneddiagnosis of prostatitis: the olmsted county study of fina Dsymptoms and health status among men. Urology, 1998, 51: 578-584
    [3]Collins MM, Meigs JB , Barry MJ , etal. Prevalence and correlatesof prostatitis in the health professionals folowuptudy cohort. JUrol, 2002, 167: 133-136
    [4]Nickel JC, Downey J, Hunter D, et al. Prevalence of prostatitis-like symptoms in a opulation based study using the National In-stitutes Of Health chronic prostatitis symptom index. JUrol, 2001; 165: 842-845
    [5]Mehik A, Hellstrom P, Lukkaf inen O, et al. Epidemiology of prostatitis in Finnish men : a opulation-based cross sectional stud). BJUInt, 2000, 86: 443-448
    [6]Mehik A , Hellstrom P, Sarpola A, et al. Fears, sexual disturbancesand personality feature sinmen with prostatitis: a opulation based—CROSS sectional study in Finland. BJU Int, 2001, 88: 35-38
    [7]Rizzo M,Marchetti F,Travaglini F,et al.Prevalence,diagnosis and treatment of prostatitis in Italy:a prospective urology outpatient practice study.BJU Int,2003,92:955-959
    [8]Mehik A,Hellstrom P,Lukkarinen O,et al.Epidemiology of prostatitis in Finnish men:a population based cross sectional study[J].Br J Urol Int,2000,86:443-448
    [9]Ku JH,Kim ME,Lee NK,et al.The prevalence of chronic prostatitis-like symptoms in young men:a community based surbey[J].Urol Res,2001,29:108-i12
    [10]Cheah CheahPY,LiongH1,YuenKH,et al.Chronic prostatitis:symptom survey with follow-up clinical evaluation.Urology,2003:61:60-64
    [11]Kunishima Y,Matsukawa M,Takahashi S,et al.Nationa Ilnst-tutes of Health hronic prostatitis symptom inder forJapanese-men.Urology.2002,60:74-77
    [12]夏同礼,孔祥田,宓培,等.我国成人前列腺非特异性炎.中华泌尿外科杂志.1986,16:711-713
    [13]李宏军,黄宇烽.前列腺炎的流行病学研究进展.中华泌尿外科杂志.2004,(3):312-313
    [14]WenningermK,HeimanJR,RothmanI,etal.JUrol,1996,155:965-968
    [15]KriggerJN, EganKE. Urology, 1991, 38:11-19
    
    [16]Shoskes DA, AlbakriQ, Thomas K, et al. Cytokine polymorphisms in Men with chronic prostatitis/chronic pelvic pain syndrome:Association with diagnosis andtreatment response [J]. Jurol, 2002,168 (1): 331-335
    
    [17]Nichel JC, Alexander RB, Schaeffer AJ, et al. Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syn-dmme compared to asymptomatic controls[J]. Jurol,2003, 170(3):818-822
    
    [18]De la Rosette JJ, Hubregtse MR, Karthaus HF, et al. Results of a questionnaire among Dutch urologists and general practitioners concerning diagnostics and treatment of patient with rostatitis syndromes[J].EurUrol,1992,22(1) :14-19
    
    [19]Doble A , Corter SSC . Ultrasonographic findings in prostatitis. Urol Clin North Am, 1989, 16: 763-772
    
    [20]Shoskes DA, Albakri Q, Thomas K, et al. Cytokine polymorphisms in Men with chronic prostatitis/chronic pelvic pain syndrome : Association withdiagnosis and treatment response[J].J Urol, 2002,168(1): 331-335
    
    [21]Miller LJ,Fischer KA, Goralnick SJ, et al. Interleukin-10 Levels in seminal plasma : Implications for chronic pro-statitis/chronic syndrome[J].Jurol,2002,167:753-756
    [22]Paulis G,Conti E,Boliani S,et al.Evaluation of the cytokines in genital secretions of patients with chronic prostatitis[J].Arch Ital Urol androl,2003,75:179-186
    [23]李宏军.慢性前列腺炎的病因学、分类及病理.医学新知杂志。2006,16(2):48
    [24]EganKJ,KriggerJL.Pain,1997,69:213-218
    [25]TrueLD,BergerRE,RothmanI,etal.JUrol.1999,162(6):148
    [26]宋波,金锡御,刘志平.中华泌尿外科杂志.1995,16(2):78
    [27]Clemens JQ,NadlerRB,SchaefferAJ.Urology,2000,56:951-955
    [28]ZermannDH,IshigookaM,DoggweilerR,etal.WorldJUrol,2001;19(3):173-179
    [29]ZermannDH,DoggweilerR,IshigookaM,etal.NeurourolUrodyn,1998,17:44
    [30]Fowler JE Jr.Anrimicrobial therapu for bacterial and nonbacterial prostatitis[J].Urology,2002,606A:24-26
    [31]Cheah PY,Liong ML,Krieger JN.Terazosin therapy for CP/CPPS:randomized placebo control trial[J].J Urol,2003,169:592-596
    [32]Pontari MA.Inflammation and anti-inflammatory therapy in chronic prostatitis[J].Urology,2002,606A:29-33
    [33]谢志光,张雪培,顿金庚,等.自由基清除剂治疗慢性前列腺炎的 病例对照研究[J].中华泌尿外科杂志.2001,22(8):493
    [34]Dimitrakov JD,Dikov DY,Lagny-sur marine cedex.Mycophenolate mofetil in the treatment of CPPS.A double-blind placebo-controllde study[J].J Urol,2003,AUA SUPPL:112
    [35]Asadawa K,Nandachi N,Satoh S.etal.Effects of cernitinpollerr extract(cernilton) on inflammatory cytokines in sex hormone induced nonbacterial prostatitisrats[J].Hingokikakiyo,2001,47(7):459-465
    [36]Ports JM.Therapeutic optiom for clmmic prostatitic /chronic pelvic pain aynadrome Curt UroL Rep.2005,6(4):313-317
    [37]蔡岳斌,钟惟德,王良圣.帕罗西丁治疗病原体阴性慢性前列腺炎35例疗效观察[J].新医学.200l,32(3):155.
    [38]钦元根,秦荣海.直肠微波加中药口服治疗慢性前列腺炎疗效分析.苏州医学院学报,1999,19(9):1021-1022
    [39]林芝,黎承阳.射频热疗治疗慢性前列腺炎36例总结.右江医学杂志.1998,26(2):77-78
    [40]陈龙,李如眉,金伟,等.射频热疗联合普适泰治疗慢性前列腺炎.中国临床医学杂志.1999,6(2):145-46
    [41]李宗来,魏宗顺.射频治疗慢性前列腺炎75例l临床分析.临床泌尿外科杂志.1995,10(2):103
    [42]徐祗顺.CP的诊断和治疗.2004年青岛国际泌尿外科新进展研 讨会论文汇编.青岛,2004:45-50
    [43]触镇美.有关慢性前列腺炎及慢性盆腔疼痛综合征的新认识[J].中华泌尿外科杂志.2003,24(8):509-510
    [44]郭应禄,李宏军主编.前列腺炎[M].北京:人民军医出版社,2002:362-364
    [45]李宏军.慢性前列腺炎的病因学、分类及病理.医学新知杂志.2006,16(2):63
    [46]Krieger IN,Jacobs RR,Ross So.Does the chronic prostatitis -pelvic pain syndrome difer from nonbacterial prostahis and prostatodynia J Urol,2000:164:1554-1558
    [47]郭应禄,李宏军主编.前列腺炎[M].北京:人民军医出版社,2002:162
    [48]贺大林,周锋.何辉,等.前列腺按摩液中IL-8和TNF-a测定在慢性前列腺炎诊断、分型中的临床意义.中华男科学杂志,2004,10(10):740-742
    [49]Diserio GP,Nowotny E.Experimental autoimmune protatitis:in vivoinduction of the autoimmune response to lymphocytic soluble factors.Alterations at the endocrine metabolism level[J].Am J Reprod Immunol,1998,39(4):226
    [50]Yasumoto R,Kawano M,TsujinoT,etal.Seminl plasma cytokiner innonbacterial prostatitis:changesfollowingcytokines in nonbacterial prostatitis:changes following sparftoxacin treatment[J].Hinyokika Kiyo,1995,41(10):771
    [51]Alexander RB,Ponniah S,Hasday J,et al.Urology 1998,52:744-749
    [52]Razumov SV,Medvedev AA,Chirun.Roleofcytokines in the diagnosis of chronic prostatitis[J].Urologia,2003,(6):25
    [53]叶海云,侯树珲,白文俊,等慢性前列腺炎患者前列腺液IL-6和IL-8表达变化及意义[J].中华泌尿外科杂志,2003,24(4):279-281
    [54]杨进益,叶林,姜洪波,等.慢性前列腺炎患者前列腺液IL-1 β和TNF-α的检测及意义[J].中华男科学,2004,10(6):459-450
    [55]汪岩,赵忠文,王立波.前列腺液中细胞因子(IL-6、TNF-α)在慢性前列腺炎中的意义[J].白求恩医科大学学报,1999,25(4):402-403
    [56]Zermann DH,Ishigooka M,Doggweiler R,et al.J Urol 1999,161:903-908
    [57]Barbalias CA.Urology 1990,36:146-153
    [58]BarbaliasGA,MearesEMJr,SantGR.Prostatodynia:Clinic lan -durodynamic characteristics[J].JUrol,1983,130(3):514--517
    [59]邓春华,辛钟成,李红军,等.男科病诊治学.2004:416
    [60]何乐业,蒋先镇.第三届各国尿流动力学学术会议论文摘要汇编.2001:126-127
    [61]De la Rosette JJ,Hubregtse MR,Karthaus HF,et al.Results of a questionnaire among Dutch urologists and general practitioners concerning diagnostics and treatment of patients with prostatitis syndromes[J].Eur Urol,1992,22(1):14-9
    [62]秦云峰.对中医“男胞”-前列腺生理功能再认识[J].中华男科学.2003,9(1):76-78.
    [63]王峻,陈铭.崔学教教授对慢性前列腺炎的病因证治观.四川中医.2006,24(4):2-3
    [64]曾庆琪.漫性前列腺炎病因病机探析.南京中医药大学学报.2005,21(3):140-141
    [65]陈志强.慢性前列腺炎证治[C].广东省第四届中医男科暨第一届中西医结合男科学术交流会论文集.2002,12:43
    [66]吕建林.中西医结合治疗慢性前列腺炎50例疗效观察[J].新中医.2003,35(11):42-43
    [67]张建敏,郭军.疏肝理气法治疗慢性非细菌性前列腺炎的临床研究[J].中华男科学,2002,8(1):76-78
    [68]田子农,耿元卿,等.慢性前列腺炎从血瘀论治的实验与临床研究进展.甘肃中医.2003,16(3):15
    [69]胡劲倍.小金片治疗前列腺肥大排尿困难20例.浙江中医杂志,1989,(8):356
    [70]冷方南主编.中国基本中成药(一部).北京:人民卫生出版社,1988:416
    [71]吴明章等编.男性生殖病理学.上海:科学普及出版社.1997:178
    [1]梁杰,王聪一.自拟通淋汤治疗慢性前列腺炎48例[J].国医论坛,2001,16(6):32-33
    [2]周安方.慢性前列腺炎病机及治则探要.中医药学刊,2003,21(4):623-624
    [3]周伟强,贾金铭.治疗慢性前列腺炎经验[J].实用中医药杂志,2003,19(6):317
    [4]乔艳荣,李晓慧.自拟前列通治疗慢性前列腺炎52例[J].陕西中医,2000,21(3):114
    [5]张书祥.“通淋祛浊汤”治疗慢性非细菌性前列腺炎88例[J].江苏中医药,2003,24(2):33
    [6]蒋学洲,江京力,周智恒.中西结合治疗慢性前列腺炎80例[J].上海中医药杂志,2001,35(12):27-28
    [7]刘建邦.辨证治疗慢性前列腺炎32例体会[J].新疆中医药,2002,20(1):19
    [8]陈磊,夏卫平,周智恒.活血清热法治疗慢性非细菌性前列腺炎 60例[J].湖南中医药导报,2002,5(5):260-261
    [9]谢坚,李慈春.加味血府逐淤汤治疗慢性非细菌性前列腺炎80例临床观察[J].中国男科学杂志,2004,18(3):36-38
    [10]尹国良,刘旭生.黄春林治疗前列腺炎经验[J].中医杂志,2001,42(1):19
    [11]彭煜.泉宁方治疗非细菌性前列腺炎的临床观察[J].上海中医药杂志,2004,5(5):35-36
    [12]邱永生.前列汤治非细菌性前列腺炎47例报告[J].江西中医药,2000,2(1):16
    [13]段登志,龚晓霞,张琼.自拟清热活血汤治疗慢性非细菌性前列腺炎53例疗效观察[J].云南中医中药杂志,2004,25(2):19
    [14]蔡洁武.活血利湿汤治疗慢性前列腺炎60例[J].实用中医药杂志,2001,17(10):11
    [15]邵国辉.中药灌肠治疗慢性非细菌性前列腺炎49例[J].中医外治杂志,2004,12(6):7
    [16]田江水.前列灌肠液治疗慢性前列腺炎72例[J].中医外治杂志,2001,10(3):27
    [17]伦学斌.八正散灌肠治疗前列腺炎20例报告[J].甘肃中医,2002,15(1):36
    [18]苗后清.清热解毒活血方保留灌肠治疗慢性前列腺炎64例[J].中医外治杂志,2000,9(1):15
    [19]崔飞禅,等.中药灌肠加外敷治疗慢性非细菌性前列腺炎52例 [J].新中医,2004,7(7):67
    [20]吴忠益.活血化疲法治疗慢性前列腺炎52例.湖南中医杂志,1997,13(6):28-29
    [21]魏文浩.慢性前列腺炎[J].河南中医,2001,21(5):12
    [22]曾晔等.自拟坐盆汤坐浴治疗慢性非细菌性前列腺炎55例疗效观察[J].云南中医中药杂志,2005,26(1):15-16
    [23]陈全寿,廖伟森.中药外治慢性前列腺炎50例疗效观察[J].浙江中医杂志,2000,35(2):50
    [24]刘紫庭,等.川参通直接注入前列腺治疗慢性非细菌性前列腺炎/慢性盆腔疼痛综合征[J].中华男科学杂志,2005,9(9):705-707
    [25]王铠.针灸辨证治疗慢性前列腺炎30例[J].四川中医,2002,20(1):72-73
    [26]孙自学,吴宏东.芒针治疗慢性非细菌性前列腺炎的临床研究[J].中医药学刊,2003,21(1):77
    [27]何馨.针灸治疗慢性前列腺炎36例临证观察[J].中医药学刊,2001,19(4):387
    [28]何天有,赵耀东,雒成林.针刺“三阴穴”治疗慢性前列腺炎临床观察[J].中国针灸,2004,24(10):697-698
    [29]王振琴,刘明,徐燕,等.针刺阴茎根部4穴为主治疗慢性前列腺炎100例临床分析[J].中国针灸,2002,22(3):155-156
    [30]陈孝银.针灸治疗慢性前列腺炎3l例.中国针灸.2006,26(2): 140
    [31]沈卫东.针灸治疗慢性非细菌性前列腺炎临床观察[J].上海中医药杂志,2000,6(5):32
    [32]吴立红,刘友波.傍针刺中极、秩边穴治疗慢性前列腺炎11例临床观察[J].针灸临床杂志,1999,15(5):26-27
    [33]洪文.温针灸治疗慢性前列腺炎30例[J].浙江中医杂志,2001,(6):266-267
    [34]于漾,康井利.温针灸治疗慢性前列腺炎临床研究[J].辽宁中医杂志,2004,31(9):775-776
    [35]李义芳.火针治疗前列腺炎22例观察[J].中国针灸,1996,(6):21-22
    [36]韩亚兰,张健,等..艾灸和中药并用治疗面部黄褐斑58例临床观察.中国临床医药研究杂志,2006,149:71
    [37]鲍身涛,中医综合疗法治疗慢性前列腙炎临床疗效分析.中国性科学,2006,15(8):25

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