朱砂根和密花石豆兰活性成分的研究
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摘要
本文使用稻瘟霉活性筛选模型(Pyricularia oryzae bioassay)和肿瘤细胞体外活性测试方法(MTT法)对紫金牛属植物朱砂根(Ardisia crenata Sims)和石豆兰属植物密花石豆兰(Bulbophillum odoratissimum Lindl.)进行了活性化合物的追踪分离及结构鉴定工作。
利用现代色谱手段从朱砂根的干燥根茎中分离得到24个化合物，通过化学和光谱学方法鉴定了它们的结构，它们分别是：岩白菜素bergenin(1)，朱砂根皂苷Iardisicrenoside I(2)~*，朱砂根皂苷J ardisicrenoside J(3)~*，朱砂根皂苷K ardisicrenoside K(4)~*，百两金皂苷A ardisiacrispin A(5)，百两金皂苷B ardisiacrispin B(6)，朱砂根皂苷B ardisicrenoside B(7)，朱砂根皂苷A ardisicrenoside A(8)，朱砂根皂苷D ardisicrenoside
D(9)，朱砂根皂苷M ardisicrenoside M(10)~*，朱砂根皂苷C ardisicrenoside C(11)，朱砂根皂苷L ardisicrenoside L(12)~*，朱砂根皂苷H ardisicrenoside H(13)，朱砂根皂苷G
ardisicrenoside G(14)，3β-O-{β-D-木吡喃糖基-(1→2)-β-D-葡萄吡喃糖基-(1→4)-[β-D-葡萄吡喃糖基-(1→2)]-α-L-阿拉伯吡喃糖基}-16α，28-二羟基-齐墩果-12-烯-30-醛3β-O-{β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl}-16α，28-dibydroxy-olean-12-en-30-aldehydc(15)，3β，16α-二羟基-30-甲氧基-28，30-环氧-齐墩果-12-烯 3β，16α-dihydroxy-30-methoxy-28，30-epoxy-olean-12-en(16)，2，4，6-三羟基苯甲酸2，4，6-tribydroxybenzoic acid(17)，朱砂根皂苷P ardisicrenoside P(18)~*，西克拉明皂苷元A-3β-O-β-D-葡萄吡喃糖基-(1→2)-α-L-阿拉伯吡喃糖苷cyclamiretin A-3β-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranoside(19)，西克拉明皂苷元A-3β-O-β-D-葡萄吡喃糖基-(1→4)-α-L-阿拉伯吡喃糖苷cyclamiretin A-3β-O-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranoside(20)，西克拉明皂苷元A-3β-O-β-D-木吡喃糖基-(1→2)-β-D-葡萄吡喃糖基-(1→4)-α-L-阿拉伯吡喃糖苷cyclamiretin A-3β-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranoside(21)，西克拉明皂苷元A-3β-O-α-L-鼠李吡喃糖基-(1→2)-β-D-葡萄吡喃糖基-(1→4)-α-L-阿拉伯吡喃糖苷cyclamiretin A-3β-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranoside(22)，朱砂根皂苷N ardisicrenoside N(23)~*，朱砂根皂苷O ardisicrenoside O(24)~*。这24个化合物中，化合物16为三萜皂苷元类化合物，化合物1和17为小分子化合物，其余的21个化合物均为五环三萜皂苷类化合物。其中化合物2，3，4，10，12，18，23，24为新化合物，化合物15-17，19-22为首次
沈阳药科大学体士学位论文
摘县
云百百百面面.面面面困面口口面万
从该属植物中分离得到。
利用现代色谱手段从密花石豆兰的干燥全草中分离得到29个化合物，通过化学和
光谱学方法鉴定了它们的结构，分别是:2，2，一二轻基一3，3‘一二甲氧基一4，5一亚甲二氧基二
节(2，2‘一dihydz·oxy一3，3‘一dimethoxy一4，5一methylenedioxybibenzyl)(1)*，3，一轻基·3，5‘一二甲氧
基一4，5一亚甲一二氧基二节(3’·hydroxy一3，5‘一 dimethoxy一4，5一ethylenedioxybibenzyl)(2)*，
2，3，一二经基一3一甲氧基一4，5一亚甲二氧基二节(2，3，一diliydroxy·3-methoxy-4，
5一methyleoedioxybibenzyl)(3)，3‘，3一二经基一4，5一亚甲二氧基二节(3’，3·dihydroxy-4，
5一methylened互oxybibenzyl)(4)，3‘一经基一3一甲氧基一4，5一亚甲二氧基二节
(3’一勿droxy一3一methoxy一4，5一methylenediox沙ibenZyl)(5)，2一轻基一5一甲氧基一3，4，3‘，4’一二
亚甲二氧基二节(2一hy由oxy一5一methoxy·3，4，3‘，4‘一dimethylenedioxybibenZyl)(6)，5‘一经基
一5一甲氧基一2，2‘一氧骄一3，4一亚甲二氧基二节(弘坤droxy一5一methoxy一2，2’·。抑in-3，4-
methylenedioxybibenzyl)(7)，4，5‘一二经基一3，3’一二甲氧基二节(4，5‘一dihydro材·3，
3’一dimethox乃七ibenzyl)(s)，4，5‘一二轻基一3，3’，5一三甲氧基二节(4，5‘·diliydroxy一3，3‘，
5一trimethoxybibenzyl)(9)，3，3‘一二经基一5‘一甲氧基二节(batatasin 111)(10)，3‘一轻基一3，5-
二甲氧基二节(3’一妙droxy一3，5一dimethoxybibenZyl)(11)，2气(3“，5气二甲氧基一4即一经基苯
基升3’一经基一2‘，3‘一二氢一4H-毗喃[5，，6‘一112一经基·5一甲氧基菲[2‘一(3“，
5“一dimethoxy·4，‘一hydro郑benzyl)一3‘一hydroxy一2‘，3‘一dihydrO.4H-pyrano[5‘，6‘一习2一drO材-
5一methox即henanthrene](12)*，2，7一二轻基一3，4一二甲氧基菲(2，7·dlhydroxy一3，
4一dimethox)，henanthrene)(13)，2，5·二轻基一3，4一二甲氧基菲(2，5·dihydroxy·3，
4一dimethox)，henant脉ne)(14)，2，7一二轻基·4一甲氧基菲(2，
7一dihydro:
In this dissertation, the Pyricularia oryzae bioassay was used to search anticancer compounds, 24 compounds were obtained from Ardisia crenata Sims and 29 compounds were obtained from Bulbophyllum odoratissimum Lindl.. Their structures were elucidated on the basis of chemical evidences and spectral analysis.
The 24 compounds from A. crenata Suns are bergenin (1), ardisicrenoside I (2)*, ardisicrenoside J (3)*, ardisicrenoside K (4)*, ardisiacrispin A (5), ardisiacrispin B (6), ardisicrenoside B (7), ardisicrenoside A (8), ardisicrenoside D (9), ardisicrenoside M (10)*, ardisicrenoside C (11), ardisicrenoside L (12)*, ardisicrenoside H (13), ardisicrenoside G (14), 3B-0-{p-D-xylopyranosyl-(1- 2)-B-D-glucopyranosyl-(l - 4)-[(B-D-glucopyranosyl-(l -2)]-a-L-arabinopyranosyl}-16a, 28-dihydroxy-olean-12-en-30-aldehyde(15), 3p, 16a-dihydroxy-30-methoxy-28, 30-epoxy-olean-12-en (16), 2, 4, 6-trihydroxybenzoic acid (17), ardisicrenoside P (18)*, 3p-0-[p-D-glucopyranosyl-(l -* 2)-a-L-arabinopyranosyl] cyclamiretin A(19), 3p-O-[p-D-glucopyranosyl-(1-4)-a-L-arabuiopyranosyl] cyclamiretin A(20), 3B-0-[B-D-xylopyranosyl-(l -2)-p-D-glucopyranosyl-(1-4)-a-L-arabinopyranosyl] cyclamiretin A(21), 3B-0-[a-L-rhamnopyranosyl-(1 - 2)-B-D-glucopyranosyl-(1 - 4) -a-L-arabinopyranosyl] cyclamiretin A (22), ardisicrenoside N (23) *, ardi
sicrenoside 0 (24) *, respectively. Compound 2, 3, 4,10,12,18,23 and 24 are new, compound 15-17 and 19-22 were isolated for the first time from Ardisia genus.
The 29 compounds from Bulbophyllum odoratissimum Lindl. are 2, 2'-dihydroxy-3, 3'-dimethoxy-4, 5-methylenedioxybibenzyl (1)*, 3'-hydroxy-3, 5'-dimethoxy-4, 5-methylenedioxybibenzyl (2)*, 2, 3'-dihydroxy-3-methoxy-4, 5-methylenedioxybibenzyl (3), 3', 3-dihydroxy-4, 5-methylenedioxybibenzyl (4), 3'-hydroxy-3-methoxy-4, 5-methylenedioxybibenzyl (5), 2-hydroxy-5-methoxy-3, 4, 3', 4'-dimethylenedioxybibenzyl (6), 5'-hydroxy-5-methoxy-2, 2'-oxrpin-3, 4-methylenedioxybibenzyl (7), 4, 5'-dihydroxy-3, 3'-dimethoxybibenzyl (8), 4, 5'-dihydroxy-3, 3', 5-trimethoxybibenzyl (9), batatasin III(10), 3'-hydroxy-3, 5-dimethoxybibenzyl (11), 2'-(3", 5"-dunethoxy-4"-hydroxybenzyl)-3'-hydroxy-2', 3'-dihydro-4H-pyrano [5', 6'-i]2-hydroxy-5-methoxyphenanthrene (12)*, 2,
7-dihydroxy-3, 4-dimethoxyphenanthrene(13), 2, 5-dihydroxy-3, 4-dimethoxyphenanthrene (14), 2, 7-dihydroxy-4-methoxyphenanthrene (IS), 2, 7-dihydroxy-3, 4-dimethoxy-9, 10-dihydrophenanthrene(16), 2, 7-dihydroxy-4-methoxy-9, 10-dihydrophenanthrene (17), 2, 7-dihydroxy-3, 4, 6-trimethoxy-9, 10-dihydrophenanthrene (18), 4, 5-dihydroxy-2, 3-dihydroindenespiro-3'-methoxy-4', 5'-methylenedioxy-3', 5'-diene-cyclohex-2'-one (19)*, (+)-lyoniresinol-3a-O-B-D-glucopyranoside (20), 3-hydroxyphenethyl alcohol 3-O-(6'-O-p-D-apioruranosyl)-p-D-glucopyranoside (21)*, 3-methoxyphenethyl alcohol 4-O-B-D-glucopyranoside (22), 3, 5-dimethoxyphenethyl alcohol 4-0-p-D-glucopyranoside (23), syringin (24), p-hydroxy-phenylpropionic acid (25), p-hydroxyphenylpropionic methyl ester (26), 3-methoxy-4-hydroxycinnamic aldehyde (27), 4-hydroxy-2, 6-dimethoxybenzaldehyde (28), orsellinic ethyl ester (29), respectively. 1,2,12,19 and 21 are new compounds, 8, 9,14,17,18, 20, 22-29 were isolated from Bulbophyllum genus for the first time.
Among the 53 compounds, triterpenoid saponins from A. crenata Sims showed potent activity against Pyricularia oryzae, however, bibenzyls, phenanthrenes and dihydrophenanthrenes from Bulbophyllum odoratissimum Lindl. had relatively very weak activity.
MTT method was also used to test the cytotoxic activity of these compounds on MCF-7, NCI-H460 and SF-268 cancer cell lines recommended by NCI. Triterpenoid saponins from A. crenata Sims also showed strong cytotoxic activities. Bibenzyl, phenanthrene and dihydrophenanthrene from B. odoratissimum Lindl. were inactive except that 3'-hydroxy-3-methoxy-4, 5-methylenedioxybibenzyl (5) and 5'-hydroxy-5-methoxy-2, 2'-oxrpin-3, 4- methylenedioxybibenzyl(7) had relatively weak activity. The cytotoxicity on HepG2 and Hep3B cell lines, two kinds of human li
利用现代色谱手段从朱砂根的干燥根茎中分离得到24个化合物，通过化学和光谱学方法鉴定了它们的结构，它们分别是：岩白菜素bergenin(1)，朱砂根皂苷Iardisicrenoside I(2)~*，朱砂根皂苷J ardisicrenoside J(3)~*，朱砂根皂苷K ardisicrenoside K(4)~*，百两金皂苷A ardisiacrispin A(5)，百两金皂苷B ardisiacrispin B(6)，朱砂根皂苷B ardisicrenoside B(7)，朱砂根皂苷A ardisicrenoside A(8)，朱砂根皂苷D ardisicrenoside
D(9)，朱砂根皂苷M ardisicrenoside M(10)~*，朱砂根皂苷C ardisicrenoside C(11)，朱砂根皂苷L ardisicrenoside L(12)~*，朱砂根皂苷H ardisicrenoside H(13)，朱砂根皂苷G
ardisicrenoside G(14)，3β-O-{β-D-木吡喃糖基-(1→2)-β-D-葡萄吡喃糖基-(1→4)-[β-D-葡萄吡喃糖基-(1→2)]-α-L-阿拉伯吡喃糖基}-16α，28-二羟基-齐墩果-12-烯-30-醛3β-O-{β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl}-16α，28-dibydroxy-olean-12-en-30-aldehydc(15)，3β，16α-二羟基-30-甲氧基-28，30-环氧-齐墩果-12-烯 3β，16α-dihydroxy-30-methoxy-28，30-epoxy-olean-12-en(16)，2，4，6-三羟基苯甲酸2，4，6-tribydroxybenzoic acid(17)，朱砂根皂苷P ardisicrenoside P(18)~*，西克拉明皂苷元A-3β-O-β-D-葡萄吡喃糖基-(1→2)-α-L-阿拉伯吡喃糖苷cyclamiretin A-3β-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranoside(19)，西克拉明皂苷元A-3β-O-β-D-葡萄吡喃糖基-(1→4)-α-L-阿拉伯吡喃糖苷cyclamiretin A-3β-O-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranoside(20)，西克拉明皂苷元A-3β-O-β-D-木吡喃糖基-(1→2)-β-D-葡萄吡喃糖基-(1→4)-α-L-阿拉伯吡喃糖苷cyclamiretin A-3β-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranoside(21)，西克拉明皂苷元A-3β-O-α-L-鼠李吡喃糖基-(1→2)-β-D-葡萄吡喃糖基-(1→4)-α-L-阿拉伯吡喃糖苷cyclamiretin A-3β-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranoside(22)，朱砂根皂苷N ardisicrenoside N(23)~*，朱砂根皂苷O ardisicrenoside O(24)~*。这24个化合物中，化合物16为三萜皂苷元类化合物，化合物1和17为小分子化合物，其余的21个化合物均为五环三萜皂苷类化合物。其中化合物2，3，4，10，12，18，23，24为新化合物，化合物15-17，19-22为首次
沈阳药科大学体士学位论文
摘县
云百百百面面.面面面困面口口面万
从该属植物中分离得到。
利用现代色谱手段从密花石豆兰的干燥全草中分离得到29个化合物，通过化学和
光谱学方法鉴定了它们的结构，分别是:2，2，一二轻基一3，3‘一二甲氧基一4，5一亚甲二氧基二
节(2，2‘一dihydz·oxy一3，3‘一dimethoxy一4，5一methylenedioxybibenzyl)(1)*，3，一轻基·3，5‘一二甲氧
基一4，5一亚甲一二氧基二节(3’·hydroxy一3，5‘一 dimethoxy一4，5一ethylenedioxybibenzyl)(2)*，
2，3，一二经基一3一甲氧基一4，5一亚甲二氧基二节(2，3，一diliydroxy·3-methoxy-4，
5一methyleoedioxybibenzyl)(3)，3‘，3一二经基一4，5一亚甲二氧基二节(3’，3·dihydroxy-4，
5一methylened互oxybibenzyl)(4)，3‘一经基一3一甲氧基一4，5一亚甲二氧基二节
(3’一勿droxy一3一methoxy一4，5一methylenediox沙ibenZyl)(5)，2一轻基一5一甲氧基一3，4，3‘，4’一二
亚甲二氧基二节(2一hy由oxy一5一methoxy·3，4，3‘，4‘一dimethylenedioxybibenZyl)(6)，5‘一经基
一5一甲氧基一2，2‘一氧骄一3，4一亚甲二氧基二节(弘坤droxy一5一methoxy一2，2’·。抑in-3，4-
methylenedioxybibenzyl)(7)，4，5‘一二经基一3，3’一二甲氧基二节(4，5‘一dihydro材·3，
3’一dimethox乃七ibenzyl)(s)，4，5‘一二轻基一3，3’，5一三甲氧基二节(4，5‘·diliydroxy一3，3‘，
5一trimethoxybibenzyl)(9)，3，3‘一二经基一5‘一甲氧基二节(batatasin 111)(10)，3‘一轻基一3，5-
二甲氧基二节(3’一妙droxy一3，5一dimethoxybibenZyl)(11)，2气(3“，5气二甲氧基一4即一经基苯
基升3’一经基一2‘，3‘一二氢一4H-毗喃[5，，6‘一112一经基·5一甲氧基菲[2‘一(3“，
5“一dimethoxy·4，‘一hydro郑benzyl)一3‘一hydroxy一2‘，3‘一dihydrO.4H-pyrano[5‘，6‘一习2一drO材-
5一methox即henanthrene](12)*，2，7一二轻基一3，4一二甲氧基菲(2，7·dlhydroxy一3，
4一dimethox)，henanthrene)(13)，2，5·二轻基一3，4一二甲氧基菲(2，5·dihydroxy·3，
4一dimethox)，henant脉ne)(14)，2，7一二轻基·4一甲氧基菲(2，
7一dihydro:
In this dissertation, the Pyricularia oryzae bioassay was used to search anticancer compounds, 24 compounds were obtained from Ardisia crenata Sims and 29 compounds were obtained from Bulbophyllum odoratissimum Lindl.. Their structures were elucidated on the basis of chemical evidences and spectral analysis.
The 24 compounds from A. crenata Suns are bergenin (1), ardisicrenoside I (2)*, ardisicrenoside J (3)*, ardisicrenoside K (4)*, ardisiacrispin A (5), ardisiacrispin B (6), ardisicrenoside B (7), ardisicrenoside A (8), ardisicrenoside D (9), ardisicrenoside M (10)*, ardisicrenoside C (11), ardisicrenoside L (12)*, ardisicrenoside H (13), ardisicrenoside G (14), 3B-0-{p-D-xylopyranosyl-(1- 2)-B-D-glucopyranosyl-(l - 4)-[(B-D-glucopyranosyl-(l -2)]-a-L-arabinopyranosyl}-16a, 28-dihydroxy-olean-12-en-30-aldehyde(15), 3p, 16a-dihydroxy-30-methoxy-28, 30-epoxy-olean-12-en (16), 2, 4, 6-trihydroxybenzoic acid (17), ardisicrenoside P (18)*, 3p-0-[p-D-glucopyranosyl-(l -* 2)-a-L-arabinopyranosyl] cyclamiretin A(19), 3p-O-[p-D-glucopyranosyl-(1-4)-a-L-arabuiopyranosyl] cyclamiretin A(20), 3B-0-[B-D-xylopyranosyl-(l -2)-p-D-glucopyranosyl-(1-4)-a-L-arabinopyranosyl] cyclamiretin A(21), 3B-0-[a-L-rhamnopyranosyl-(1 - 2)-B-D-glucopyranosyl-(1 - 4) -a-L-arabinopyranosyl] cyclamiretin A (22), ardisicrenoside N (23) *, ardi
sicrenoside 0 (24) *, respectively. Compound 2, 3, 4,10,12,18,23 and 24 are new, compound 15-17 and 19-22 were isolated for the first time from Ardisia genus.
The 29 compounds from Bulbophyllum odoratissimum Lindl. are 2, 2'-dihydroxy-3, 3'-dimethoxy-4, 5-methylenedioxybibenzyl (1)*, 3'-hydroxy-3, 5'-dimethoxy-4, 5-methylenedioxybibenzyl (2)*, 2, 3'-dihydroxy-3-methoxy-4, 5-methylenedioxybibenzyl (3), 3', 3-dihydroxy-4, 5-methylenedioxybibenzyl (4), 3'-hydroxy-3-methoxy-4, 5-methylenedioxybibenzyl (5), 2-hydroxy-5-methoxy-3, 4, 3', 4'-dimethylenedioxybibenzyl (6), 5'-hydroxy-5-methoxy-2, 2'-oxrpin-3, 4-methylenedioxybibenzyl (7), 4, 5'-dihydroxy-3, 3'-dimethoxybibenzyl (8), 4, 5'-dihydroxy-3, 3', 5-trimethoxybibenzyl (9), batatasin III(10), 3'-hydroxy-3, 5-dimethoxybibenzyl (11), 2'-(3", 5"-dunethoxy-4"-hydroxybenzyl)-3'-hydroxy-2', 3'-dihydro-4H-pyrano [5', 6'-i]2-hydroxy-5-methoxyphenanthrene (12)*, 2,
7-dihydroxy-3, 4-dimethoxyphenanthrene(13), 2, 5-dihydroxy-3, 4-dimethoxyphenanthrene (14), 2, 7-dihydroxy-4-methoxyphenanthrene (IS), 2, 7-dihydroxy-3, 4-dimethoxy-9, 10-dihydrophenanthrene(16), 2, 7-dihydroxy-4-methoxy-9, 10-dihydrophenanthrene (17), 2, 7-dihydroxy-3, 4, 6-trimethoxy-9, 10-dihydrophenanthrene (18), 4, 5-dihydroxy-2, 3-dihydroindenespiro-3'-methoxy-4', 5'-methylenedioxy-3', 5'-diene-cyclohex-2'-one (19)*, (+)-lyoniresinol-3a-O-B-D-glucopyranoside (20), 3-hydroxyphenethyl alcohol 3-O-(6'-O-p-D-apioruranosyl)-p-D-glucopyranoside (21)*, 3-methoxyphenethyl alcohol 4-O-B-D-glucopyranoside (22), 3, 5-dimethoxyphenethyl alcohol 4-0-p-D-glucopyranoside (23), syringin (24), p-hydroxy-phenylpropionic acid (25), p-hydroxyphenylpropionic methyl ester (26), 3-methoxy-4-hydroxycinnamic aldehyde (27), 4-hydroxy-2, 6-dimethoxybenzaldehyde (28), orsellinic ethyl ester (29), respectively. 1,2,12,19 and 21 are new compounds, 8, 9,14,17,18, 20, 22-29 were isolated from Bulbophyllum genus for the first time.
Among the 53 compounds, triterpenoid saponins from A. crenata Sims showed potent activity against Pyricularia oryzae, however, bibenzyls, phenanthrenes and dihydrophenanthrenes from Bulbophyllum odoratissimum Lindl. had relatively very weak activity.
MTT method was also used to test the cytotoxic activity of these compounds on MCF-7, NCI-H460 and SF-268 cancer cell lines recommended by NCI. Triterpenoid saponins from A. crenata Sims also showed strong cytotoxic activities. Bibenzyl, phenanthrene and dihydrophenanthrene from B. odoratissimum Lindl. were inactive except that 3'-hydroxy-3-methoxy-4, 5-methylenedioxybibenzyl (5) and 5'-hydroxy-5-methoxy-2, 2'-oxrpin-3, 4- methylenedioxybibenzyl(7) had relatively weak activity. The cytotoxicity on HepG2 and Hep3B cell lines, two kinds of human li
引文
1．小林久芳，具有微管机能阻碍作用的微生物代谢产物的研究(日本东京大学，博士论文，1997)
2. Takahashi, M., Iwasaki, S., Kobayashi, H., Et al., Studies on Macrocyclic Lacton Antibiotics Ⅺ, Antimitotic and Anti-tubulin Activity of new Antitumor Antibiotics, Rhizoxins andits Homologues, J. Antibiotics, 1987, 40, 66-72
3. Kobayashi, H., Namikoshi, M., Yoshimoto, T., Et al., a screening Method ofr Antimitotic application to Tropical Marine Fungi, J. Antibiotics, 1996, 49(9), 873-879
4. Kobayashi, H., Sunaga, G., Furihara, K., Et al., Isolation and Structures of an Antifungal Antibiotic fusarielin A, and Related Compounds Produced by a Fusarium sp, J. Antibiotics, 1995, 48, 42-52
5. Sekita, S., Yoshihira, K., Natori, S., Et al., Chaetoglobosins, Cytotoxic 10-(indol-3-yl)-[13]cyto-charasans from Chaetomium sp, Chem. Pharm. Bull., 1982, 30, 1609-1617
6. Hu, k., Dong, A. J., Yao, X. S., Et al., Antineoplastic Agents I. Three Spirostanol Glycosides from Rhizomes of Dioscorea colletii var. hypoglauca, Planta Med., 1996, 62, 573-575
7. Hu, k., Dong, A. J., Yao, X. S., Et al., Antineoplastic Angents Ⅱ. Four Furostanol Glycosides from Rhizomes of Dioscorea collettii var. hypoglauca, Planta Med., 1997, 63, 161-165
8. Hu, k., Dong, A. J., Yao, X. S., Et al., A Furostanol Glycoside from Dioscorea collettii var. hypolauca, Phytochemistry, 1997, 44(7), 1339-1342
9. Hu, k., Dong, A. J., Yao, X. S., Et al., Antineoplastic Steroidal Saponins from Rhizomes of Dioscorea collettii var. hypoglauca, Stud. Plant Sci., 1999, 6 (Advances in Plant Glycosides, Chemistry and Biology), 220-229
10. Hu, k., Yao, X. S., Methyl protogracillin (NSC-698792): the spectrum of cytotoxicty against 60 human cancer cell lines in the National Cancer Institute's anticancer drug screen panel, Anti-Cancer Drugs, 2001, 12(6), 541-547
11．闫少羽，黑果黄皮Clausena dunniana Levl．抗癌活性成分的研究(沈阳药科大学博士学位论文，2001)
12．赵庆春，中药粗叶悬钩子Rubus aleaefolius Poir．中细胞周期抑制及细胞凋亡诱导活性成分的研究(沈阳药科大学博士学位论文，2001)
13．沈平，圆果三角叶薯蓣和弯蕊开口箭活性成分的研究(沈阳药科大学博士学位论文，2002)
14．刘宏伟，天然产物抗癌活性成分研究(沈阳药科大学博士学位论文，2003)
15．中国科学院中国植物志编辑委员会．中国植物志，北京：科学出版社，1979，58，42．
16．张清华．紫金牛属植物化学成分研究概况．华西药学杂志，1994，9(2)，99-103．
17．赵亚，刘合刚．紫金牛属植物研究近况．中草药，1999，30(3)，228-231．
18．宿树兰，李永辉，欧阳臻等．紫金牛属药用植物中三萜皂苷成分的研究进展．中药材，2003，26(2)，144-148．
19. Nirjhar Malviya, P Pal, N M Khanna. Cheminca examination of Ardisia neriifalia Wall. Indian Journal of Chemistry, 1989, 28B, 522-523
20. Chaweewan Jansukul, Herbert Baumann, Lennart Kenne et al. Ardsiacrispin A and B, Two Utero-Contracting Saponins from Ardisia crispa. Planta Medica, 1987, 53(5), 405-409
21. Zhonghua Jia, Kazuo Koike, Taichi Ohmoto et al. Triterpenoid Saponins From Aridsia crenata. Phytochemistry, 1994, 37, 1389-1396.
22. Jia, Zhonghua, Koike Kazuo, Nikaido Tamotsu et al. Triterpenoid saponins from Ardisia crenata and their inhibitory activity on cAMP phosphodiesterase.. Chem. Pharm. Bull. 1994, 42(11), 2309-14.
23. Zhonghua Jia, Kazuo Koike, Tamotsu Nikaido et al. Two Novel Triterpenoid Pentasaccharides with an Unusual Glycosyl Glycerol Side Chain from Aridsia crenata. Tetrahedron, 1994, 50(41), 11853-11864.
24. Kazuo Koike, Zhonghua Jia, Saori Ohura et al. Minor Triterpenoid Saponins from Aridsia crenata. Chem. Pharm. Bull. 1999, 47(3), 434-435.
25. Wang Maotan, Guan Xiongtai, Han Xiuwen et al. A New Triterpenoid Saponin from Aridsia crenata. Planta Med. 1992, 58(2), 205-207.
26. Jing Huang, Yukio Ogihara, Hao Zhang et al. Triterpenoid saponins from Ardisia mamillata. Phytochemistry, 2000, 54, 817-822.
27. Jing Huang, Yukio Ogihara, Hao Zhang et al. Ardisimamillosides C-F, Four New Triterpenoid Saponins from Ardisia mamillata. Chem. Pharm. Bull. 2000, 48(10),
1413-1417.
28. Jing Huang, Hao Zhang, Noriko Shimizu et al. Ardisimamillosides G and H, Two New Triterpenoid Saponins from Ardisia mamillata. Chem. Pharm. Bull. 2003, 51(7), 875-877.
29. Nunziatina De Tommasi, Sonia Piacente, Francesco De Simone et al. CHARACTERIZATION OF THREE NEW TRITERPENOID SAPONINS FROM ARDISIA JAPONICA. Journal of Natural Products, 1993, 56(10), 1669-1675.
30. Sonia Piacente, Cosimo Pizza, Nunziatina De Tommasi. Constituents of Ardisia japonica and Their in Vitro Anti-HIV Activity. Journal of Natural Products, 1996, 59(6), 565-569.
31．张清华，王晓娟，缪振春等．川产九节龙皂甙的化学研究．药学学报，1993，28(9)，673-678．
32．缪振春，冯锐，周永新等．四川九节龙中新四糖三萜皂苷结构和核磁共振研究．有机化学，2000，20(3)，361-366．
33．蒋朝晖，贾宪生，续俊文等．江南紫金牛(月月红)皂甙的化学研究(Ⅰ)．中草药，1988，19(12)，2-5．
34．蒋朝晖，贾宪生，续俊文等．江南紫金牛(月月红)皂甙的化学研究(Ⅱ)．中草药，1989，20(1)，2-5．
35. Luo SQ, Lin LZ, Cordell GA. Saikosaponin Derivatives from Bupleurum falcatum. Phytochemistry, 1996, 41(3), 1197-1199.
36．江西省新医学院编．中药大辞典(下册)．上海：科学技术出版社，1986，2358-2360．
37．中国科学院中国植物志编辑委员会．中国植物志，北京：科学出版社，1979，19，172．
38. Majumder P. L., Kar Amita and Shoolery J. N. Bulbophyllanthrin, a phenanthrene of the orchid Bulbophyllum leopardium. Phytochemistry, 1985, 24(9), 2083-2087.
39. Majumder P. L., Banerjee S. A ring-B oxygenated phenanthrene derivative from the orchid Bulbophyllum gymnopus. Phytochemistry, 1988, 27(1), 245-248.
40. Leong Yuan-Wah, Kang Chiang-Cheong, Harrison Leslie J. Phenanthrenes, dihydrophenanthrenes and bibenzyls from the orchid Bulbophyllum vaginatum. Phytochemistry, 1997, 44(1), 157-165.
41. Leong Yuan-Wah, Harrison Leslie J., Powell Andrew D. Phenanthrene and other aromatic constituents of Bulbophyllum vaginatum. Phytochemistry, 1999, 50(7), 1237-1241.
42. Majumder P. L., Pal S., Majumder S. Dimeric phenanthrenes from the orchid Bulbophyllum reptans. Phytochemistry, 1999, 50(5), 891-897.
43. Majumder P. L., Sen R. C. Bulbophyllanthrone, a phenanthraquinone from Bulbophyllum odoratissimum. Phytochemistry, 1991, 30(6), 2092-2094.
44. Majumder P. L, Pal S. Cumulatin and tristin, two bibenzyl derivatives from the orchids Dendrobium cumulatum and Bulbophyllum triste. Phytochemistry, 1993, 32(6), 1561-1565.
45. Majumder P. L., Roychowdhury M., Chakraborty S, Bibenzyl derivatives from the orchid Bulbophyllum protractum. Phytochemistry, 1997, 44(1), 167-172.
46. George R. P., Shen B. S., Jean M. S. Isolation, structure, synthesis and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum. Journal of Natural Products, 1988, 51(3), 517-527.
47. Gorham J. Prog. Phytochem., 1980, 6, 203.
48. Pryce R. J. Phytochemistry, 1972, 11, 1759-1761.
49. Mosmann. T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay, J. Immunol. Meth. 1993, 13, 711-719.
50. Mahato S. B. Kundu A. P. ~(13)C-NMR spectra of pentacyclic triterpenoids-a compilation and some salient features. Phytochemistry, 1994, 37, 1517-1575.
51. Agrawal P. K. Phytochemistry, 1992, 31, 3307-3330.
52. Masatosh taneyama Isolation of norbergenin from saxifraga stolonifera. Phytochemistry, 1983, 22, 1053-1054.
53. Catherine Lavaud, Georges Massiot, Jose Bravo Barrera et.al Triterpenoid saponins from Myrsine pellucida. Phytochemistry, 1994, 37, 1671-1677.
54. Luo SQ, Lin LZ, Cordell GA. Saikosaponin Derivatives from Bupleurum falcatu. Phytochemistry, 1996, 41(3), 1197-1199.
55. P.L. Majumder, M. Roychowdhury and S. Chakraborty Bibenzyl Derivatives from the Orchid Bulbophyllum protractum. Phytochemistry, 1997, 44, 167-172
56. P.K. Juneja, S. C. Sharma and J.S.Tandon A Substituted 1,2-diarylethane from Cymbidium Giganteum. Phytochemistry 1985, 24(2), 321-324
57. Hala N. Elsohly, Guang-En Ma, Carlton E. Turner and Mahmoud A. Elsohly, Constituents of Cannabis sativa ⅩⅩⅤ Isolation of two new dihydrostilbenes from a Panamanian variant. Journal of Natural Products, 1984, 47(3), 445-452.
58. Kusum Sachdev and Dinesh K. Kulshreshtha Phenolic constituents of Coelogyne ovalis.
Phytochemistry, 1986, 25 (2), 499-502.
59. Majumder R L. Roychowdhury M. and Chakraborty S. Thunalbene, a stilbene derivative from the orchid Thunia alba. Phytochemistry, 1998, 49(8), 2375-2378.
60. Majumder EL. Joardar M. Erianthridin, a new 9, 10-dihydrophenanthrene derivative from the orchids Eria carinata & Eria stricta. Indian Journal of Chemistry, 1985, 24B(11), 1192-1194.
61. Samuel Estrada, Ruben A. Toscano, and Rachel Mata. New phenanthrene Derivatives from Maxillaria Densa, Journal of Natural Products, 1999, 62, 1175-1178.
62. P. L. Majumder and Saswati Lahira. Lusianthrin and Lusianthridin, two stilbenoids from the orchid Lusia indivisa, Phytochemistry, 1990, 29 (2), 621-624.
63. Shuzo Takagi, Masae Yamaki and Keiko Inoue. Antimocrobial agents from Bletilla striata, Phytochemistry, 22(4), 1011-1015.
64. P. L. Majumder and Swapna Laha. Occurrence of 2, 7-dihydroxy-3, 4, 6-trimethoxy-dihydrophenanthrene in Coelogyne ovalis, J. Indian Chem. Soc., 1981, 58(9), 928-929.
65. Christoph Steinbeck, Christiane Schneider, Klacus Rotscheidt. A 4-methyl-7-hydroxyphthalide glycoside and other constituents from Quillaja saponaria Molina. Phytochemistry, 1995, 40(4), 1313-5.
66．张治针，果德安，李长龄．滇白珠木脂素苷的研究．药学学报，1999，34(2)，128-131．
67. Hidehiko Kijima, Toshinori Ide, Hideake Otsuka, Choei Ogimi, Eiji Hirata, Anki Takushi and Yoshio Takeda. Water-soluble Phenolic Glycosides from leaves of Alangium Premnifolium, Phytochemistry, 1997, 44(8), 1551-1557.
68. Marina Della Greca, Maria Ferrara, Antonio Fiorentino, Pietro Monaco and Lucio Previtera. Antialgal compounds from Zantedeschia Aethiopica. Phytochemistry, 1998, 49(5), 1299-1304.
69．谷口直之、铃木敬一朗，NO生理作用疾患，羊土社，2000．
70. Akihiro D., Shigeki K., Jin B. W., Susumu K. Anti-allergic agents from natural sources(4): anti-allergic activity of new phloroglulcinol derivatives from Mallotus philippensis. Euphorbiaceae, 2002, 50, 1566-1659.
71. Crombie Leslie, Mary W., Crombie L. Natural products of Thailand high Δ1-THC-Strain Cannabis. The bibenzyl-spiran-dihydrophenanthrene Group: Relations with
Cannabinoids and Canniflavones. J.Chem. Soc. Perkin Trans. I, 1982, 1455-1466.
72. Crombie Leslie, Dewick Paul M. Donald A. Biosynthesis of Rotenoids. Chalone, Isoflavone, and Rotenoid Stages in the Formation of Amorphigenin by Amorpha fruticosa Seedlings. J.Chem. Soc. Perkin Trans. I, 1973, 1285-1294.
2. Takahashi, M., Iwasaki, S., Kobayashi, H., Et al., Studies on Macrocyclic Lacton Antibiotics Ⅺ, Antimitotic and Anti-tubulin Activity of new Antitumor Antibiotics, Rhizoxins andits Homologues, J. Antibiotics, 1987, 40, 66-72
3. Kobayashi, H., Namikoshi, M., Yoshimoto, T., Et al., a screening Method ofr Antimitotic application to Tropical Marine Fungi, J. Antibiotics, 1996, 49(9), 873-879
4. Kobayashi, H., Sunaga, G., Furihara, K., Et al., Isolation and Structures of an Antifungal Antibiotic fusarielin A, and Related Compounds Produced by a Fusarium sp, J. Antibiotics, 1995, 48, 42-52
5. Sekita, S., Yoshihira, K., Natori, S., Et al., Chaetoglobosins, Cytotoxic 10-(indol-3-yl)-[13]cyto-charasans from Chaetomium sp, Chem. Pharm. Bull., 1982, 30, 1609-1617
6. Hu, k., Dong, A. J., Yao, X. S., Et al., Antineoplastic Agents I. Three Spirostanol Glycosides from Rhizomes of Dioscorea colletii var. hypoglauca, Planta Med., 1996, 62, 573-575
7. Hu, k., Dong, A. J., Yao, X. S., Et al., Antineoplastic Angents Ⅱ. Four Furostanol Glycosides from Rhizomes of Dioscorea collettii var. hypoglauca, Planta Med., 1997, 63, 161-165
8. Hu, k., Dong, A. J., Yao, X. S., Et al., A Furostanol Glycoside from Dioscorea collettii var. hypolauca, Phytochemistry, 1997, 44(7), 1339-1342
9. Hu, k., Dong, A. J., Yao, X. S., Et al., Antineoplastic Steroidal Saponins from Rhizomes of Dioscorea collettii var. hypoglauca, Stud. Plant Sci., 1999, 6 (Advances in Plant Glycosides, Chemistry and Biology), 220-229
10. Hu, k., Yao, X. S., Methyl protogracillin (NSC-698792): the spectrum of cytotoxicty against 60 human cancer cell lines in the National Cancer Institute's anticancer drug screen panel, Anti-Cancer Drugs, 2001, 12(6), 541-547
11．闫少羽，黑果黄皮Clausena dunniana Levl．抗癌活性成分的研究(沈阳药科大学博士学位论文，2001)
12．赵庆春，中药粗叶悬钩子Rubus aleaefolius Poir．中细胞周期抑制及细胞凋亡诱导活性成分的研究(沈阳药科大学博士学位论文，2001)
13．沈平，圆果三角叶薯蓣和弯蕊开口箭活性成分的研究(沈阳药科大学博士学位论文，2002)
14．刘宏伟，天然产物抗癌活性成分研究(沈阳药科大学博士学位论文，2003)
15．中国科学院中国植物志编辑委员会．中国植物志，北京：科学出版社，1979，58，42．
16．张清华．紫金牛属植物化学成分研究概况．华西药学杂志，1994，9(2)，99-103．
17．赵亚，刘合刚．紫金牛属植物研究近况．中草药，1999，30(3)，228-231．
18．宿树兰，李永辉，欧阳臻等．紫金牛属药用植物中三萜皂苷成分的研究进展．中药材，2003，26(2)，144-148．
19. Nirjhar Malviya, P Pal, N M Khanna. Cheminca examination of Ardisia neriifalia Wall. Indian Journal of Chemistry, 1989, 28B, 522-523
20. Chaweewan Jansukul, Herbert Baumann, Lennart Kenne et al. Ardsiacrispin A and B, Two Utero-Contracting Saponins from Ardisia crispa. Planta Medica, 1987, 53(5), 405-409
21. Zhonghua Jia, Kazuo Koike, Taichi Ohmoto et al. Triterpenoid Saponins From Aridsia crenata. Phytochemistry, 1994, 37, 1389-1396.
22. Jia, Zhonghua, Koike Kazuo, Nikaido Tamotsu et al. Triterpenoid saponins from Ardisia crenata and their inhibitory activity on cAMP phosphodiesterase.. Chem. Pharm. Bull. 1994, 42(11), 2309-14.
23. Zhonghua Jia, Kazuo Koike, Tamotsu Nikaido et al. Two Novel Triterpenoid Pentasaccharides with an Unusual Glycosyl Glycerol Side Chain from Aridsia crenata. Tetrahedron, 1994, 50(41), 11853-11864.
24. Kazuo Koike, Zhonghua Jia, Saori Ohura et al. Minor Triterpenoid Saponins from Aridsia crenata. Chem. Pharm. Bull. 1999, 47(3), 434-435.
25. Wang Maotan, Guan Xiongtai, Han Xiuwen et al. A New Triterpenoid Saponin from Aridsia crenata. Planta Med. 1992, 58(2), 205-207.
26. Jing Huang, Yukio Ogihara, Hao Zhang et al. Triterpenoid saponins from Ardisia mamillata. Phytochemistry, 2000, 54, 817-822.
27. Jing Huang, Yukio Ogihara, Hao Zhang et al. Ardisimamillosides C-F, Four New Triterpenoid Saponins from Ardisia mamillata. Chem. Pharm. Bull. 2000, 48(10),
1413-1417.
28. Jing Huang, Hao Zhang, Noriko Shimizu et al. Ardisimamillosides G and H, Two New Triterpenoid Saponins from Ardisia mamillata. Chem. Pharm. Bull. 2003, 51(7), 875-877.
29. Nunziatina De Tommasi, Sonia Piacente, Francesco De Simone et al. CHARACTERIZATION OF THREE NEW TRITERPENOID SAPONINS FROM ARDISIA JAPONICA. Journal of Natural Products, 1993, 56(10), 1669-1675.
30. Sonia Piacente, Cosimo Pizza, Nunziatina De Tommasi. Constituents of Ardisia japonica and Their in Vitro Anti-HIV Activity. Journal of Natural Products, 1996, 59(6), 565-569.
31．张清华，王晓娟，缪振春等．川产九节龙皂甙的化学研究．药学学报，1993，28(9)，673-678．
32．缪振春，冯锐，周永新等．四川九节龙中新四糖三萜皂苷结构和核磁共振研究．有机化学，2000，20(3)，361-366．
33．蒋朝晖，贾宪生，续俊文等．江南紫金牛(月月红)皂甙的化学研究(Ⅰ)．中草药，1988，19(12)，2-5．
34．蒋朝晖，贾宪生，续俊文等．江南紫金牛(月月红)皂甙的化学研究(Ⅱ)．中草药，1989，20(1)，2-5．
35. Luo SQ, Lin LZ, Cordell GA. Saikosaponin Derivatives from Bupleurum falcatum. Phytochemistry, 1996, 41(3), 1197-1199.
36．江西省新医学院编．中药大辞典(下册)．上海：科学技术出版社，1986，2358-2360．
37．中国科学院中国植物志编辑委员会．中国植物志，北京：科学出版社，1979，19，172．
38. Majumder P. L., Kar Amita and Shoolery J. N. Bulbophyllanthrin, a phenanthrene of the orchid Bulbophyllum leopardium. Phytochemistry, 1985, 24(9), 2083-2087.
39. Majumder P. L., Banerjee S. A ring-B oxygenated phenanthrene derivative from the orchid Bulbophyllum gymnopus. Phytochemistry, 1988, 27(1), 245-248.
40. Leong Yuan-Wah, Kang Chiang-Cheong, Harrison Leslie J. Phenanthrenes, dihydrophenanthrenes and bibenzyls from the orchid Bulbophyllum vaginatum. Phytochemistry, 1997, 44(1), 157-165.
41. Leong Yuan-Wah, Harrison Leslie J., Powell Andrew D. Phenanthrene and other aromatic constituents of Bulbophyllum vaginatum. Phytochemistry, 1999, 50(7), 1237-1241.
42. Majumder P. L., Pal S., Majumder S. Dimeric phenanthrenes from the orchid Bulbophyllum reptans. Phytochemistry, 1999, 50(5), 891-897.
43. Majumder P. L., Sen R. C. Bulbophyllanthrone, a phenanthraquinone from Bulbophyllum odoratissimum. Phytochemistry, 1991, 30(6), 2092-2094.
44. Majumder P. L, Pal S. Cumulatin and tristin, two bibenzyl derivatives from the orchids Dendrobium cumulatum and Bulbophyllum triste. Phytochemistry, 1993, 32(6), 1561-1565.
45. Majumder P. L., Roychowdhury M., Chakraborty S, Bibenzyl derivatives from the orchid Bulbophyllum protractum. Phytochemistry, 1997, 44(1), 167-172.
46. George R. P., Shen B. S., Jean M. S. Isolation, structure, synthesis and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum. Journal of Natural Products, 1988, 51(3), 517-527.
47. Gorham J. Prog. Phytochem., 1980, 6, 203.
48. Pryce R. J. Phytochemistry, 1972, 11, 1759-1761.
49. Mosmann. T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay, J. Immunol. Meth. 1993, 13, 711-719.
50. Mahato S. B. Kundu A. P. ~(13)C-NMR spectra of pentacyclic triterpenoids-a compilation and some salient features. Phytochemistry, 1994, 37, 1517-1575.
51. Agrawal P. K. Phytochemistry, 1992, 31, 3307-3330.
52. Masatosh taneyama Isolation of norbergenin from saxifraga stolonifera. Phytochemistry, 1983, 22, 1053-1054.
53. Catherine Lavaud, Georges Massiot, Jose Bravo Barrera et.al Triterpenoid saponins from Myrsine pellucida. Phytochemistry, 1994, 37, 1671-1677.
54. Luo SQ, Lin LZ, Cordell GA. Saikosaponin Derivatives from Bupleurum falcatu. Phytochemistry, 1996, 41(3), 1197-1199.
55. P.L. Majumder, M. Roychowdhury and S. Chakraborty Bibenzyl Derivatives from the Orchid Bulbophyllum protractum. Phytochemistry, 1997, 44, 167-172
56. P.K. Juneja, S. C. Sharma and J.S.Tandon A Substituted 1,2-diarylethane from Cymbidium Giganteum. Phytochemistry 1985, 24(2), 321-324
57. Hala N. Elsohly, Guang-En Ma, Carlton E. Turner and Mahmoud A. Elsohly, Constituents of Cannabis sativa ⅩⅩⅤ Isolation of two new dihydrostilbenes from a Panamanian variant. Journal of Natural Products, 1984, 47(3), 445-452.
58. Kusum Sachdev and Dinesh K. Kulshreshtha Phenolic constituents of Coelogyne ovalis.
Phytochemistry, 1986, 25 (2), 499-502.
59. Majumder R L. Roychowdhury M. and Chakraborty S. Thunalbene, a stilbene derivative from the orchid Thunia alba. Phytochemistry, 1998, 49(8), 2375-2378.
60. Majumder EL. Joardar M. Erianthridin, a new 9, 10-dihydrophenanthrene derivative from the orchids Eria carinata & Eria stricta. Indian Journal of Chemistry, 1985, 24B(11), 1192-1194.
61. Samuel Estrada, Ruben A. Toscano, and Rachel Mata. New phenanthrene Derivatives from Maxillaria Densa, Journal of Natural Products, 1999, 62, 1175-1178.
62. P. L. Majumder and Saswati Lahira. Lusianthrin and Lusianthridin, two stilbenoids from the orchid Lusia indivisa, Phytochemistry, 1990, 29 (2), 621-624.
63. Shuzo Takagi, Masae Yamaki and Keiko Inoue. Antimocrobial agents from Bletilla striata, Phytochemistry, 22(4), 1011-1015.
64. P. L. Majumder and Swapna Laha. Occurrence of 2, 7-dihydroxy-3, 4, 6-trimethoxy-dihydrophenanthrene in Coelogyne ovalis, J. Indian Chem. Soc., 1981, 58(9), 928-929.
65. Christoph Steinbeck, Christiane Schneider, Klacus Rotscheidt. A 4-methyl-7-hydroxyphthalide glycoside and other constituents from Quillaja saponaria Molina. Phytochemistry, 1995, 40(4), 1313-5.
66．张治针，果德安，李长龄．滇白珠木脂素苷的研究．药学学报，1999，34(2)，128-131．
67. Hidehiko Kijima, Toshinori Ide, Hideake Otsuka, Choei Ogimi, Eiji Hirata, Anki Takushi and Yoshio Takeda. Water-soluble Phenolic Glycosides from leaves of Alangium Premnifolium, Phytochemistry, 1997, 44(8), 1551-1557.
68. Marina Della Greca, Maria Ferrara, Antonio Fiorentino, Pietro Monaco and Lucio Previtera. Antialgal compounds from Zantedeschia Aethiopica. Phytochemistry, 1998, 49(5), 1299-1304.
69．谷口直之、铃木敬一朗，NO生理作用疾患，羊土社，2000．
70. Akihiro D., Shigeki K., Jin B. W., Susumu K. Anti-allergic agents from natural sources(4): anti-allergic activity of new phloroglulcinol derivatives from Mallotus philippensis. Euphorbiaceae, 2002, 50, 1566-1659.
71. Crombie Leslie, Mary W., Crombie L. Natural products of Thailand high Δ1-THC-Strain Cannabis. The bibenzyl-spiran-dihydrophenanthrene Group: Relations with
Cannabinoids and Canniflavones. J.Chem. Soc. Perkin Trans. I, 1982, 1455-1466.
72. Crombie Leslie, Dewick Paul M. Donald A. Biosynthesis of Rotenoids. Chalone, Isoflavone, and Rotenoid Stages in the Formation of Amorphigenin by Amorpha fruticosa Seedlings. J.Chem. Soc. Perkin Trans. I, 1973, 1285-1294.