65例系统性红斑狼疮患者抗中性粒细胞胞浆抗体临床意义的分析
摘要
目的：探讨抗中性粒细胞胞浆抗体(ANCA)与系统性红斑狼疮(SLE)的关系及临床意义。方法：回顾性分析65例SLE患者ANCA的检测结果，以及ANCA与SLE主要临床表现、实验室检查结果的关系，SLE患者病情活动组与非活动组ANCA阳性率及核型分布的比较。结果：IIF法检测ANCA在SLE中的阳性率是61.5％，ANCA阳性组中有血管炎皮损(67.5％)及浆膜炎(55.0％)者明显高于阴性组(P＜0.05)。同时ANCA阳性组与阴性组比较，在24小时尿蛋白大于0.5g/l，血红蛋白低于90g/l，抗ds-DNA抗体阳性，低补体血症方面差别有统计学意义(P＜0.05)。结论：ANCA在SLE患者中有一定的阳性率，且与疾病的活动程度及肾脏受累具有相关性。
Objective: To study the relationship between antineutrophil cytoplasmic antibodies(ANCA) and systemic lupus erythematosus(SLE). Methods: Clinical data of 65 patients with systemic lupus erythematosus, who were examined ANCA in the sera by indirect immunoflourescence technique(IIF),were studied retrospectively. Results: The positive rate of ANCA in SLE patients was 61.5% by IIF The patients with cutaneous vasculitic manifestation in the group of positive ANCA were more than ones in the group of negtive ANCA, the difference between the two groups was very significant(P<0.05). So were the patients with serositis. There also was significant difference in exceeding 0.5g/l of urinary protein in 24 hours, patients with positive anti ds-DNA, lowing 90g/l of Hb, patients with hypocomplementemia(P<0.05). Conclusion: ANCA in some patients with SLE were positive. ANCA might be correlated with lupus activities and renal's invasions.
Objective: To study the relationship between antineutrophil cytoplasmic antibodies(ANCA) and systemic lupus erythematosus(SLE). Methods: Clinical data of 65 patients with systemic lupus erythematosus, who were examined ANCA in the sera by indirect immunoflourescence technique(IIF),were studied retrospectively. Results: The positive rate of ANCA in SLE patients was 61.5% by IIF The patients with cutaneous vasculitic manifestation in the group of positive ANCA were more than ones in the group of negtive ANCA, the difference between the two groups was very significant(P<0.05). So were the patients with serositis. There also was significant difference in exceeding 0.5g/l of urinary protein in 24 hours, patients with positive anti ds-DNA, lowing 90g/l of Hb, patients with hypocomplementemia(P<0.05). Conclusion: ANCA in some patients with SLE were positive. ANCA might be correlated with lupus activities and renal's invasions.
引文
1． 蒋明主编．风湿病学．第一版．北京：科学出版社，1995：1037
2. Manolova, -I; Oancheva, -M; Halacheva, -K. Ant ineutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus:prevalence, antigen specificity, and clinical associations. Rheumato1-Int. 2001 Jul, 20(5):197-204
3． 罗婷，赵明辉，马圣清．抗中性粒细胞胞浆抗体在系统性红斑狼疮中的临床意义．中华皮肤科杂志，1999，32(1)：20-21
4． 戴慧光，李慧珠，沈丹蓓等．系统性红斑狼疮患者中抗中性粒细胞胞浆抗体和抗心磷脂抗体的检测．中华皮肤科杂志，1998；31(1)：18-19
5. Galeazzi, -M;Morozzi, -G;Sebastiani, -G-D, eta1. Antineutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus: prevalence, clinical associations and correlation with other autoantibodies. European Concerted Action on the Immunogenetics of SLE. Clin-Exp-Rheumatol. 1998 Sep-Oct; 16(5):541-6
6. Chin,-H-J;Ahn,-c;Lim,-C-S, etal. Clinical implications of antineutrophil cytoplasmic antibody test in lupus nephritis. Am-J-Nephrol. 2000 Jan-Feb; 20(1):57-63
2. Manolova, -I; Oancheva, -M; Halacheva, -K. Ant ineutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus:prevalence, antigen specificity, and clinical associations. Rheumato1-Int. 2001 Jul, 20(5):197-204
3． 罗婷，赵明辉，马圣清．抗中性粒细胞胞浆抗体在系统性红斑狼疮中的临床意义．中华皮肤科杂志，1999，32(1)：20-21
4． 戴慧光，李慧珠，沈丹蓓等．系统性红斑狼疮患者中抗中性粒细胞胞浆抗体和抗心磷脂抗体的检测．中华皮肤科杂志，1998；31(1)：18-19
5. Galeazzi, -M;Morozzi, -G;Sebastiani, -G-D, eta1. Antineutrophil cytoplasmic antibodies in 566 European patients with systemic lupus erythematosus: prevalence, clinical associations and correlation with other autoantibodies. European Concerted Action on the Immunogenetics of SLE. Clin-Exp-Rheumatol. 1998 Sep-Oct; 16(5):541-6
6. Chin,-H-J;Ahn,-c;Lim,-C-S, etal. Clinical implications of antineutrophil cytoplasmic antibody test in lupus nephritis. Am-J-Nephrol. 2000 Jan-Feb; 20(1):57-63