针灸治疗高胆固醇血症优化方案的临床研究
|
摘要
高脂血症是指血清(或血浆)中一种或几种脂质浓度明显升高。而血脂过高是引起心脑血管疾病的原因之一,其中胆固醇的升高是引起冠心病、动脉粥样硬化等心血管疾病的重要因素。而高胆固醇血症是高脂血症西医分型中的一种。随着社会的发展,人们生活水平提高的同时,工作、家庭压力也在增大,这都导致了人们饮食结构及生活习惯的改变,最终引起高脂血症的发生率逐年增高和向中年人群发展的趋势。人们也逐渐地认识到胆固醇异常是冠心病的重要、独立的危险因素。因此,如何防治高胆固醇血症,特别是探索非药物调脂的有效方法,对防治心脑血管疾病的发生与发展有着尤为重要的意义。目前针灸在治疗高胆固醇血症方面有着很好的调脂效果。但根据有关这方面的文献统计,穴位、针灸方法及疗程长短的选择都有很大差异,临床治疗上难以规范应用。本试验采用正交试验方法设计,探寻出针灸临床治疗高胆固醇血症的最优方案。目的：通过采用不同针灸方法、选取不同经穴、配合不同疗程治疗高胆固醇血症,观察并比较治疗前、后临床效果及总胆固醇(TC)水平的变化，通过总结疗效结果,进行统计学处理、分析,从而探寻出针灸治疗高胆固醇血症的最佳组合方案。
方法：参照《中药新药临床研究指导原则》治疗高胆固醇血症的临床研究指导原则。选择3因素3水平的正交试验设计法,应用L9(34)正交试验用表,对符合试验条件的高胆固醇血症患者,采用随机分配方法,分为脾胃经穴+艾灸+治疗1个疗程组、脾胃经穴+、电针+治疗2个疗程组、脾胃经穴+穴位注射+治疗3个疗程组、背俞穴+艾灸+治疗2个疗程组、背俞穴+电针+治疗3个疗程组、背俞穴+穴位注射+治疗1个疗程组、任脉经穴+艾灸+治疗3个疗程组、任脉经穴+电针+治疗1个疗程组、任脉经穴+穴位注射+治疗2个疗程组,每组收取5例患者,共计45例。本试验研究中患者在治疗期间保持原有的饮食、生活习惯,不服用任何影响血脂代谢的药物,治疗前、后分别采血检测总胆固醇(TC)指标。
结果：通过正交试验的统计结果提示：所有组对降低血清TC值均有效果,其中以脾胃经穴+艾灸+治疗3个疗程的组合为最优(FC> FB> FA, KA1> KA3> KA2, KB1> KB3 >KB2, KC3>KC2>KC1);所有组的治疗后较治疗前中医症候积分均有不同程度下降,即所有组对各年龄层次的高胆固醇血症患者临床表现出的眩晕、头痛、胸闷、心悸、肢麻、纳差等症候均有不同程度的改善,但其中以任脉经穴+艾灸+治疗3个疗程这一组合(FC>FA>FB, KA3>KA1>KA2, KB1>KB2>KB3, KC3>KC2>KC1),对减轻高胆固醇血症患者的临床症候表现效果最佳。
结论：
(1)所有组对降低血清TC值均有效果,其中以脾胃经穴+艾灸+治疗3个疗程的组合最优；
(2)所有组对各年龄层次的高胆固醇血症患者临床表现出的眩晕、头痛、胸闷、心悸、肢麻、纳差等症候均有不同程度的改善,其中以任脉经穴+艾灸+治疗3个疗程这一组合,对减轻高胆固醇血症患者的临床症候表现效果最优。
Hyperlipidemia is refers to the serum (or plasma) one or several lipid concentration significantly increased. While high blood is one of the reasons for causing cerebrovascular and heart disease. The part of the cholesterol rising is the most important factor of causing CHD, atherosclerosis. Etc. With the development of society, people's living standards improved at the same time, and the pressure from work or family increased. These are carrying the changes in the diet and lifestyles. Finally, resulting in the raising of the incidence of hyperlipidemia and making it much younger. People also gradually realize dyslipidemia is the important and independent risk factor of CHD. Therefore, how to prevent against the hyperlipidemia, especially the effective method of non-drugs, is a particularly important meaning in cerebrovascular disease. Now in the treatment of acupuncture and moxibustion in hyperlipidemia has a very good effect of adjusting lipid. But according to the relevant literature, there are very big differences during the uses of points, methods and period of treatment on the clinical application. So I choose the orthogonal experiment in order to explore the optimal combination of acupuncture treatment on hypercholesterolemia.
Objective:By using different acupuncture methods, choosing different acupuncture points and different periods of treatment on treating hypercholesterolemia. Observing the magnitudes of total cholesterol (TC) before and after the treatment and comparing the clinical effect. Through summarizing the results to explore the optimal combination of acupuncture therapy hypercholesterolemia.
Methods:According to "The Chinese herbal medicine clinical research guiding principles" for the treatment of hypercholesterolemia clinical research guiding principle. Choosing 3 factors and 3 levels of the orthogonal test design. The application of L9(34)orthogonal test table, using random distribution method to the patients with hypercholesterolemia as points of spleen, stomach and pericardial meridian+moxibustion+1 period of treatment; points of spleen, stomach and pericardial meridian+electro acupuncture+2 periods of treatment; points of spleen, stomach and pericardial meridian+point injection+3 periods of treatment; Back-shu points+moxibustion+2 periods of treatment; Back-shu points+electro acupuncture+3 periods of treatment; Back-shu points+point injection+1 period of treatment; points of Conception Vessel+moxibustion+3 periods of treatment, points of Conception Vessel+electro acupuncture+1 period of treatment; points of Conception Vessel+point injection+2 periods of treatment; and five patients each group, totaling 45 patients. During the treatment, patients can keep the original diet and lifestyles, not taking any drugs that can make influence to blood metabolism. Before and after treatment, they should draw blood for a test of TC.
Results:Through the results of the orthogonal test:all groups could reduce the magnitude of TC. The optimal combination is the points of spleen, stomach and pericardial meridians+ moxibustion+3 periods of treatment(FC>FB>FA, KA1>KA3>KA2, KB1>KB3>KB2, KC3>KC2>KC1). All groups' symptoms of TCM are relieved after the treatment. But the optimal combination is points of Conception Vessel+moxibustion+3 periods of treatment (FC >FA>FB, KA3>KA1>KA2, KB1>KB2>KB3, KC3>KC2>KC1).
Conclusion:
(1) All groups could reduce the magnitude of TC. The optimal combination is the points of spleen, stomach and pericardial meridians+moxibustion+3 periods of treatment;
(2) All groups' symptoms of TCM are relieved after the treatment. But the optimal combination is points of Conception Vessel+moxibustion+3 periods of treatment.
方法：参照《中药新药临床研究指导原则》治疗高胆固醇血症的临床研究指导原则。选择3因素3水平的正交试验设计法,应用L9(34)正交试验用表,对符合试验条件的高胆固醇血症患者,采用随机分配方法,分为脾胃经穴+艾灸+治疗1个疗程组、脾胃经穴+、电针+治疗2个疗程组、脾胃经穴+穴位注射+治疗3个疗程组、背俞穴+艾灸+治疗2个疗程组、背俞穴+电针+治疗3个疗程组、背俞穴+穴位注射+治疗1个疗程组、任脉经穴+艾灸+治疗3个疗程组、任脉经穴+电针+治疗1个疗程组、任脉经穴+穴位注射+治疗2个疗程组,每组收取5例患者,共计45例。本试验研究中患者在治疗期间保持原有的饮食、生活习惯,不服用任何影响血脂代谢的药物,治疗前、后分别采血检测总胆固醇(TC)指标。
结果：通过正交试验的统计结果提示：所有组对降低血清TC值均有效果,其中以脾胃经穴+艾灸+治疗3个疗程的组合为最优(FC> FB> FA, KA1> KA3> KA2, KB1> KB3 >KB2, KC3>KC2>KC1);所有组的治疗后较治疗前中医症候积分均有不同程度下降,即所有组对各年龄层次的高胆固醇血症患者临床表现出的眩晕、头痛、胸闷、心悸、肢麻、纳差等症候均有不同程度的改善,但其中以任脉经穴+艾灸+治疗3个疗程这一组合(FC>FA>FB, KA3>KA1>KA2, KB1>KB2>KB3, KC3>KC2>KC1),对减轻高胆固醇血症患者的临床症候表现效果最佳。
结论：
(1)所有组对降低血清TC值均有效果,其中以脾胃经穴+艾灸+治疗3个疗程的组合最优；
(2)所有组对各年龄层次的高胆固醇血症患者临床表现出的眩晕、头痛、胸闷、心悸、肢麻、纳差等症候均有不同程度的改善,其中以任脉经穴+艾灸+治疗3个疗程这一组合,对减轻高胆固醇血症患者的临床症候表现效果最优。
Hyperlipidemia is refers to the serum (or plasma) one or several lipid concentration significantly increased. While high blood is one of the reasons for causing cerebrovascular and heart disease. The part of the cholesterol rising is the most important factor of causing CHD, atherosclerosis. Etc. With the development of society, people's living standards improved at the same time, and the pressure from work or family increased. These are carrying the changes in the diet and lifestyles. Finally, resulting in the raising of the incidence of hyperlipidemia and making it much younger. People also gradually realize dyslipidemia is the important and independent risk factor of CHD. Therefore, how to prevent against the hyperlipidemia, especially the effective method of non-drugs, is a particularly important meaning in cerebrovascular disease. Now in the treatment of acupuncture and moxibustion in hyperlipidemia has a very good effect of adjusting lipid. But according to the relevant literature, there are very big differences during the uses of points, methods and period of treatment on the clinical application. So I choose the orthogonal experiment in order to explore the optimal combination of acupuncture treatment on hypercholesterolemia.
Objective:By using different acupuncture methods, choosing different acupuncture points and different periods of treatment on treating hypercholesterolemia. Observing the magnitudes of total cholesterol (TC) before and after the treatment and comparing the clinical effect. Through summarizing the results to explore the optimal combination of acupuncture therapy hypercholesterolemia.
Methods:According to "The Chinese herbal medicine clinical research guiding principles" for the treatment of hypercholesterolemia clinical research guiding principle. Choosing 3 factors and 3 levels of the orthogonal test design. The application of L9(34)orthogonal test table, using random distribution method to the patients with hypercholesterolemia as points of spleen, stomach and pericardial meridian+moxibustion+1 period of treatment; points of spleen, stomach and pericardial meridian+electro acupuncture+2 periods of treatment; points of spleen, stomach and pericardial meridian+point injection+3 periods of treatment; Back-shu points+moxibustion+2 periods of treatment; Back-shu points+electro acupuncture+3 periods of treatment; Back-shu points+point injection+1 period of treatment; points of Conception Vessel+moxibustion+3 periods of treatment, points of Conception Vessel+electro acupuncture+1 period of treatment; points of Conception Vessel+point injection+2 periods of treatment; and five patients each group, totaling 45 patients. During the treatment, patients can keep the original diet and lifestyles, not taking any drugs that can make influence to blood metabolism. Before and after treatment, they should draw blood for a test of TC.
Results:Through the results of the orthogonal test:all groups could reduce the magnitude of TC. The optimal combination is the points of spleen, stomach and pericardial meridians+ moxibustion+3 periods of treatment(FC>FB>FA, KA1>KA3>KA2, KB1>KB3>KB2, KC3>KC2>KC1). All groups' symptoms of TCM are relieved after the treatment. But the optimal combination is points of Conception Vessel+moxibustion+3 periods of treatment (FC >FA>FB, KA3>KA1>KA2, KB1>KB2>KB3, KC3>KC2>KC1).
Conclusion:
(1) All groups could reduce the magnitude of TC. The optimal combination is the points of spleen, stomach and pericardial meridians+moxibustion+3 periods of treatment;
(2) All groups' symptoms of TCM are relieved after the treatment. But the optimal combination is points of Conception Vessel+moxibustion+3 periods of treatment.
引文
[1]West Scotland coronary prevention study group. Influence of pravastatin and plasma lipids on clinical events in the West of Scotland coronary prevention study (WOSCOPS). Circulation,1998,97:1440-1445
[2]Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (ATPⅢ)
[3]The Scandinavian simvastatin survival study group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease:the Scandinavian simvastatin survival study (4S). Lancet,1994,344:1383
[4]陈灏珠主编.《实用内科学》[M],人民卫生出版社,2007：1077-1089
[5]中华心血管病杂志编委会血脂异常防治专题组.1997.血脂异常防治建议[J].中华心血管杂,25(3)：169-172
[6]李刘英.高脂血症的中医论治[J].辽宁中医药大学学报.2009,11(11)：59
[7]周小琳.浅探中医对高脂血症的认识[J].国医论坛.2007,22(6)：14
[8]定明阳.六味降脂饮治疗高脂血症130例[J].吉林中医药,2007,27(4)：26
[9]吴沛田.高脂血症如何分型辩证[J].中医杂志,2004,45(2)：946
[10]曾庆明.浅谈从脾虚生痰生瘀论治高脂血症[J].江西中医药,2006,(2)：11-12
[11]杨莹.浅谈肾虚和痰瘀与高脂血症的关系[J].江西中医药,2006,(2)：11-12
[12]曹永芬.从脾肾肝三脏论治老年高脂血症[J].中国现代药物应用,2007,1(1)：45
[13]徐继民.痰浊型冠心病与血脂水平关系的探讨[J].中西医结合杂志,1984,(5)：266
[14]曹永康.《江苏医药》[M],1978,(1)：4
[15]玄瑞英,杨光全.高脂血症的病因及证治探析[J].实用中医内科杂志,2006,20(1)：32-33
[16]罗继红.穴位注射对高脂血症患者血脂的影响[J].上海针灸杂志,2007,26(2)：16
[17]龚一萍.高脂血症的中医病因病机探讨[J].浙江中医学院学报,2000,24(2)：23-24
[18]唐寒松.针灸从脾论治高脂血症的探讨[J].中国针灸,1998,(5)：307
[19]郑贵力.王绵之教授治疗高脂血症的学术思想及经验[J].北京中医药大学学报,2000,23(2)：48
[20]佟丽娟.高脂血症的病因病机及辨证分型治疗[J].中医药学刊,2002,20(2)：44
[21]陈如桂,马桂敏.丹荃逍遥煎治疗高脂血症46例[J].上海中医药杂志,1995,(2)：26-27
[22]张金山.高脂血症从肝论治初探[J].新中医,2006,38(11)：6-8
[23]邓汉成,廖作淳.治疗高脂血症经验[J].江西中医药,1994,25(5)：25-26
[24]赵林,赵军绩.参葛降脂宁治疗冠心病高脂血症疗效观察[J].湖北中医杂志,1999,(9)：395
[25]张愍,曾昭龙,李晓敏,等.高脂血症患者之友[J].北京人民军医出版社,1996：4
[26]马维庆.高脂血症证治诌议[J].长春中医药大学学报,2008,24(5)：513-514
[27]魏登科.高脂血症的中医药治疗思路[J].中医药研究,1997,13(6)：22-23,35
[28]王琦.中医体质学[M].北京中国医药科技出版社,1995：239
[29]袁肇凯.高脂血症痰瘀辨证的血脂和血流动力学检测分析[J].湖南中医学院学报,2001,21(3)：1-4.
[30]祝东友,张连贵.高脂血症从痰瘀论治体会[J].江苏中医药,2004,25(1)：17-18
[31]吴桂荣,毛新民,王岩,等.红花油乳剂的降血脂作用研究[J].中国新药杂志,2003,12(2)：110～111
[32]何菊英,刘松青,彭永富,等.决明子降血脂作用机制研究[J].中国药房,2003,14(4)：202-20
[33]杜力军,孙虹,李敏,等.荷叶大豆及其合剂调控活性部位的研究[J].中草药,2000,31(7)：526-528
[34]邓捷,漆萍,黄英.复方丹参滴丸治疗高脂血症疗效观察[J].实用中西医结合临床,2002,2(3)：11-12
[35]许毓政.化痰降脂方治疗高脂血症106例临床观察[J].湖南中医杂志,1994：10(3)：32
[36]刘应柯,李争,尤清波.参龙降压灵胶囊治疗高脂血症42例[J].中医研究,2003,16(1)：25-26
[37]高建东,傅荣恕,薛庆林,等.温胆降脂口服液对大鼠血脂调节作用的研究[J].医药导报,2000,19(2)：108-109
[38]何华.化痰逐瘀法为主治疗高脂血症55例临床观察[J].实用中西医结合杂志,1997,10(6)：569
[39]龙庆余.从痰瘀辩证治疗高血脂症60例[J].安徽中医临床杂志,1998,10(1)：20-21
[40]胡克武.健脾除痰降脂汤治疗高血脂症30例[J].临床观察湖南中医杂志,1997,13(4)：9
[41]王有章.益气健脾活血法治疗高脂血症40例[J].湖北中医杂志,1993,15(3)：8
[42]李业忠等.柔肝和血汤治疗高脂血症的临床观察与实验研究[J].广西中医药,1996,19(2)：1
[43]杨大男等.逍遥丸治疗高脂血症84例[J].陕西中医,1995,16(3)：109
[44]王庆莉,赵一鹏,赵然,等.芪参降脂饮对血脂的调节作用[J],辽宁中医杂志,2003,3(11)：938
[45]王钢,常建国,降脂饮治疗高脂血症76例[J].陕西中医,2002,23(8)：701-702
[46]程为平,郭继承,叶宁.针刺治疗高脂蛋白血症36例临床观察[J].针灸临床杂志,1994,10(2)：25
[47]陈德欣,吴洪英,王卓茹.针刺阳明经穴治疗高脂血症疗效观察[J].针灸临床杂志,2002,18(5)：49
[48]康凤河.针刺治疗高脂血症32例疗效观察[J].天津中医学院学报,2003,22(2)：65
[49]梁凤覆,陈瑞,毛红荣.固通结合针刺对高脂血症血清NO NOS的影响[J].辽宁中医杂志,2003,30(12)：1013-1014
[50]任敬威等.针刺足三里、内关穴治疗高脂血症45例报告[J].甘肃中医,1996；9(5)：36
[51]周杰芳,冼志红.针刺对高血脂病人的血脂及血液流变学影响的临床观察[J].广西中医药,1994,17(3)：39-41
[52]毛喜荣,王月冬,周逸平.针刺对冠心病患者血脂血糖的影响[J].针灸临床杂志,1994,10(2)：26-27
[53]王凤玲.灸神阙穴降脂抗衰老作用的研究[J].中国针灸,1996,9：29-30
[54]常小荣,周国平,严洁,等.隔药饼灸对高脂血症患者血清HDL-C、LDL-C及其脂质含量的影响[J].针刺研究,1998,(4)：272-274
[55]常小荣,严洁,林亚平,等.隔药饼灸对高脂血症患者血浆TXB2、6-酮-PGF1α的影响[J].中国中医药科技,2000,(7)：329-330
[56]邓柏颖,谢感共,罗本华,等.功能保健灸治疗高脂血症48例疗效观察[J].新中医,2002,34(9)：48-49
[57]朱红梅.壮医药线点灸合中药对2型糖尿病患者血脂的影响[J].辽宁中医杂志,2004,31(4)：337-338
[58]张露芬,程金莲,严洁,等.电针心经腧穴对大鼠高血脂血浆内皮素、降钙素基因相关肽影响的实验观察[J].中国中医基础医学杂志,2000,7(2)：60-63
[59]张露芬,严洁,程金莲,等.电针心经腧穴对大鼠高血脂症心肌琥珀酸脱氢酶、三磷酸脉苷酶活性及心 肌组织结构的影响[J].针刺研究,2000,25(3)：203-206
[60]王玉琴等.针刺对高胆固醇血症家兔影响的研究[J].中国针灸,1994,(2)：32
[61]唐胜修,唐萍.丰隆、足三里穴位注射治疗高脂血症的临床研究[J].广西医学,2000,22(6)：1402-1404
[62]杨丹红,许文波,江庆湛.穴位注射对高脂血症动物模型的降脂作用[J].针灸临床杂志,2000,16(1)：43-45
[63]袁俏梅,史红辉.穴位埋线治疗高脂血症34例-附普拉固治疗30例对照[J].浙江中医杂志,2002,9：396
[64]王倩,从莘,熊家轩.穴位埋线治疗肥胖型高脂血症52例疗效观察[J].新中医,2005,37(6)：64-65
[65]卢振初.耳压法治疗单纯性肥胖症29例的血脂和脂蛋白观察[J].南京中医学院学报,1989,(2)：40
[66]陈晓萍,郑伟莉,杨华,等.耳穴贴压法治疗高脂血症[J].上海中医药杂志,1991,(10)：27
[67]王成传,郑建寅,谢宁.哈慈五行针治疗飞行人员高脂血症疗效观察[J].中华航空航天医学杂志,2001,12(4)：239-240
[68]张丽,李东书,盛丽.磁针治疗单纯性肥胖症并发高脂血症的疗效观察[J].上海针灸杂志,2003,22(2)：7-9
[69]杨国柱,曹欣.皮内针治疗高脂血症32例临床观察[J].江苏中医药,2003,24(12)：38
[70]邵敏,温凌洁,孙蓉.穴位敷贴对Ⅱ型糖尿病患者血脂水平的影响[J].上海针灸杂志,2000,19(6)：5-6
[71]朱匙.针罐背俞穴治疗高脂血症36例临床观察[J].北京中医,2000,6：47-48
[72]赵宁侠,郭瑞林,任秦有,等.艾灸三阴交穴对健康人血液流变学及红细胞聚集指数的影响[J].云南中医学院学报,2003,26(4)：31-32
[2]Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (ATPⅢ)
[3]The Scandinavian simvastatin survival study group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease:the Scandinavian simvastatin survival study (4S). Lancet,1994,344:1383
[4]陈灏珠主编.《实用内科学》[M],人民卫生出版社,2007：1077-1089
[5]中华心血管病杂志编委会血脂异常防治专题组.1997.血脂异常防治建议[J].中华心血管杂,25(3)：169-172
[6]李刘英.高脂血症的中医论治[J].辽宁中医药大学学报.2009,11(11)：59
[7]周小琳.浅探中医对高脂血症的认识[J].国医论坛.2007,22(6)：14
[8]定明阳.六味降脂饮治疗高脂血症130例[J].吉林中医药,2007,27(4)：26
[9]吴沛田.高脂血症如何分型辩证[J].中医杂志,2004,45(2)：946
[10]曾庆明.浅谈从脾虚生痰生瘀论治高脂血症[J].江西中医药,2006,(2)：11-12
[11]杨莹.浅谈肾虚和痰瘀与高脂血症的关系[J].江西中医药,2006,(2)：11-12
[12]曹永芬.从脾肾肝三脏论治老年高脂血症[J].中国现代药物应用,2007,1(1)：45
[13]徐继民.痰浊型冠心病与血脂水平关系的探讨[J].中西医结合杂志,1984,(5)：266
[14]曹永康.《江苏医药》[M],1978,(1)：4
[15]玄瑞英,杨光全.高脂血症的病因及证治探析[J].实用中医内科杂志,2006,20(1)：32-33
[16]罗继红.穴位注射对高脂血症患者血脂的影响[J].上海针灸杂志,2007,26(2)：16
[17]龚一萍.高脂血症的中医病因病机探讨[J].浙江中医学院学报,2000,24(2)：23-24
[18]唐寒松.针灸从脾论治高脂血症的探讨[J].中国针灸,1998,(5)：307
[19]郑贵力.王绵之教授治疗高脂血症的学术思想及经验[J].北京中医药大学学报,2000,23(2)：48
[20]佟丽娟.高脂血症的病因病机及辨证分型治疗[J].中医药学刊,2002,20(2)：44
[21]陈如桂,马桂敏.丹荃逍遥煎治疗高脂血症46例[J].上海中医药杂志,1995,(2)：26-27
[22]张金山.高脂血症从肝论治初探[J].新中医,2006,38(11)：6-8
[23]邓汉成,廖作淳.治疗高脂血症经验[J].江西中医药,1994,25(5)：25-26
[24]赵林,赵军绩.参葛降脂宁治疗冠心病高脂血症疗效观察[J].湖北中医杂志,1999,(9)：395
[25]张愍,曾昭龙,李晓敏,等.高脂血症患者之友[J].北京人民军医出版社,1996：4
[26]马维庆.高脂血症证治诌议[J].长春中医药大学学报,2008,24(5)：513-514
[27]魏登科.高脂血症的中医药治疗思路[J].中医药研究,1997,13(6)：22-23,35
[28]王琦.中医体质学[M].北京中国医药科技出版社,1995：239
[29]袁肇凯.高脂血症痰瘀辨证的血脂和血流动力学检测分析[J].湖南中医学院学报,2001,21(3)：1-4.
[30]祝东友,张连贵.高脂血症从痰瘀论治体会[J].江苏中医药,2004,25(1)：17-18
[31]吴桂荣,毛新民,王岩,等.红花油乳剂的降血脂作用研究[J].中国新药杂志,2003,12(2)：110～111
[32]何菊英,刘松青,彭永富,等.决明子降血脂作用机制研究[J].中国药房,2003,14(4)：202-20
[33]杜力军,孙虹,李敏,等.荷叶大豆及其合剂调控活性部位的研究[J].中草药,2000,31(7)：526-528
[34]邓捷,漆萍,黄英.复方丹参滴丸治疗高脂血症疗效观察[J].实用中西医结合临床,2002,2(3)：11-12
[35]许毓政.化痰降脂方治疗高脂血症106例临床观察[J].湖南中医杂志,1994：10(3)：32
[36]刘应柯,李争,尤清波.参龙降压灵胶囊治疗高脂血症42例[J].中医研究,2003,16(1)：25-26
[37]高建东,傅荣恕,薛庆林,等.温胆降脂口服液对大鼠血脂调节作用的研究[J].医药导报,2000,19(2)：108-109
[38]何华.化痰逐瘀法为主治疗高脂血症55例临床观察[J].实用中西医结合杂志,1997,10(6)：569
[39]龙庆余.从痰瘀辩证治疗高血脂症60例[J].安徽中医临床杂志,1998,10(1)：20-21
[40]胡克武.健脾除痰降脂汤治疗高血脂症30例[J].临床观察湖南中医杂志,1997,13(4)：9
[41]王有章.益气健脾活血法治疗高脂血症40例[J].湖北中医杂志,1993,15(3)：8
[42]李业忠等.柔肝和血汤治疗高脂血症的临床观察与实验研究[J].广西中医药,1996,19(2)：1
[43]杨大男等.逍遥丸治疗高脂血症84例[J].陕西中医,1995,16(3)：109
[44]王庆莉,赵一鹏,赵然,等.芪参降脂饮对血脂的调节作用[J],辽宁中医杂志,2003,3(11)：938
[45]王钢,常建国,降脂饮治疗高脂血症76例[J].陕西中医,2002,23(8)：701-702
[46]程为平,郭继承,叶宁.针刺治疗高脂蛋白血症36例临床观察[J].针灸临床杂志,1994,10(2)：25
[47]陈德欣,吴洪英,王卓茹.针刺阳明经穴治疗高脂血症疗效观察[J].针灸临床杂志,2002,18(5)：49
[48]康凤河.针刺治疗高脂血症32例疗效观察[J].天津中医学院学报,2003,22(2)：65
[49]梁凤覆,陈瑞,毛红荣.固通结合针刺对高脂血症血清NO NOS的影响[J].辽宁中医杂志,2003,30(12)：1013-1014
[50]任敬威等.针刺足三里、内关穴治疗高脂血症45例报告[J].甘肃中医,1996；9(5)：36
[51]周杰芳,冼志红.针刺对高血脂病人的血脂及血液流变学影响的临床观察[J].广西中医药,1994,17(3)：39-41
[52]毛喜荣,王月冬,周逸平.针刺对冠心病患者血脂血糖的影响[J].针灸临床杂志,1994,10(2)：26-27
[53]王凤玲.灸神阙穴降脂抗衰老作用的研究[J].中国针灸,1996,9：29-30
[54]常小荣,周国平,严洁,等.隔药饼灸对高脂血症患者血清HDL-C、LDL-C及其脂质含量的影响[J].针刺研究,1998,(4)：272-274
[55]常小荣,严洁,林亚平,等.隔药饼灸对高脂血症患者血浆TXB2、6-酮-PGF1α的影响[J].中国中医药科技,2000,(7)：329-330
[56]邓柏颖,谢感共,罗本华,等.功能保健灸治疗高脂血症48例疗效观察[J].新中医,2002,34(9)：48-49
[57]朱红梅.壮医药线点灸合中药对2型糖尿病患者血脂的影响[J].辽宁中医杂志,2004,31(4)：337-338
[58]张露芬,程金莲,严洁,等.电针心经腧穴对大鼠高血脂血浆内皮素、降钙素基因相关肽影响的实验观察[J].中国中医基础医学杂志,2000,7(2)：60-63
[59]张露芬,严洁,程金莲,等.电针心经腧穴对大鼠高血脂症心肌琥珀酸脱氢酶、三磷酸脉苷酶活性及心 肌组织结构的影响[J].针刺研究,2000,25(3)：203-206
[60]王玉琴等.针刺对高胆固醇血症家兔影响的研究[J].中国针灸,1994,(2)：32
[61]唐胜修,唐萍.丰隆、足三里穴位注射治疗高脂血症的临床研究[J].广西医学,2000,22(6)：1402-1404
[62]杨丹红,许文波,江庆湛.穴位注射对高脂血症动物模型的降脂作用[J].针灸临床杂志,2000,16(1)：43-45
[63]袁俏梅,史红辉.穴位埋线治疗高脂血症34例-附普拉固治疗30例对照[J].浙江中医杂志,2002,9：396
[64]王倩,从莘,熊家轩.穴位埋线治疗肥胖型高脂血症52例疗效观察[J].新中医,2005,37(6)：64-65
[65]卢振初.耳压法治疗单纯性肥胖症29例的血脂和脂蛋白观察[J].南京中医学院学报,1989,(2)：40
[66]陈晓萍,郑伟莉,杨华,等.耳穴贴压法治疗高脂血症[J].上海中医药杂志,1991,(10)：27
[67]王成传,郑建寅,谢宁.哈慈五行针治疗飞行人员高脂血症疗效观察[J].中华航空航天医学杂志,2001,12(4)：239-240
[68]张丽,李东书,盛丽.磁针治疗单纯性肥胖症并发高脂血症的疗效观察[J].上海针灸杂志,2003,22(2)：7-9
[69]杨国柱,曹欣.皮内针治疗高脂血症32例临床观察[J].江苏中医药,2003,24(12)：38
[70]邵敏,温凌洁,孙蓉.穴位敷贴对Ⅱ型糖尿病患者血脂水平的影响[J].上海针灸杂志,2000,19(6)：5-6
[71]朱匙.针罐背俞穴治疗高脂血症36例临床观察[J].北京中医,2000,6：47-48
[72]赵宁侠,郭瑞林,任秦有,等.艾灸三阴交穴对健康人血液流变学及红细胞聚集指数的影响[J].云南中医学院学报,2003,26(4)：31-32