C-反应蛋白基因多态性与川崎病及其冠脉损害的相关性研究
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摘要
目的：研究人类C反应蛋白(CRP)基因+1059G/C、-757T/C、-717A/G多态性与川崎病(KD)发病及其冠状动脉损害(CAL)之间的关系。
方法：对30名川崎病患儿和60名对照组儿童经基因测序分别进行CRP基因+1059位点、-757位点、-717位点基因突变的检测。
结果：①KD组CRP基因+1059G/C多态性位点的GG、GC基因型分布频率和G、C等位基因频率与正常对照组比较无显著性差异(χ2=0.038、0.034,P>0.05)；合并冠脉损伤者与无冠脉损伤者基因型分布频率和等位基因频率比较亦无显著性差异(P＞0.05)。②KD组CRP基因-757T/C多态性位点的TT、TC、CC基因型分布频率和T、C等位基因频率与正常对照组比较无显著性差异(χ2=2.893、2.500,P>0.05)；合并冠脉损伤者与无冠脉损伤者基因型分布频率和等位基因频率比较亦无显著性差异(P>0.05)；③KD组CRP基因-717A/G多态性位点的AA、AG基因型分布频率和A、G等位基因频率与正常对照组比较无显著性差异(χ2均=0,P>0.05)。合并冠脉损伤者与无冠脉损伤组基因型分布频率和等位基因频率比较亦无显著性差异(P>0.05)。
结论：CRP基因的+1059G/C位点、-757T/C位点、-717A/G位点多态性与川崎病及其冠状动脉损害的发生均无明显关联性。
Objective To investigate the relationship between the genetic polymorphisms of C-reactive protein(CRP) and children with Kawasaki Disease (KD) and that complicated with coronary artery lesion (CAL).
Method Gene sequence analysis was employed to confirm the mutational sites at+1059、-757 and -717 of C-reactive protein in 30 cases of children with KD and 60 healthy children as controls group respectively.
Results①As for the+1059G/C locus of CRP gene, there were no significant differences between genotype frequency of GG and GC types in KD and healthy controls (χ2=0.038, P>0.05); there was no significant differences between allele frequency of G and C type in KD and controls(χ2=0.034, P>0.05); there were no significant differences between the frequeneies of genotype and allele of KD complicated with CAL and without CAL (all P>0.05).②For the-757T/C locus of CRP gene, there were no significant differences between genotype frequency of TT、TC and CC types in KD and healthy controls (χ2=2.893, P>0.05); there was no significant differences between allele frequeney of T and C type in KD and controls (χ2=2.500, P>0.05); there were no significant differences between the frequeneies of genotype and allele of KD complicated with CAL ang without CAL((P＞0.05).③For the-717A/G locus of CRP gene, there were no significant differences between genotype frequency of AA and AG types in KD and healthy controls(x2=0, P>0.05); there was no significant differences between allele frequeney of A and G type in KD and controls(χ2=0, P>0.05); there were no significant differences between the frequeneies of genotype and allele of KD complicated with CAL ang without CAL((P>0.05).
Conclusion:The polymorphisms of +1059G/C、-757T/C、-717A/G locus of CRP gene had not been found association with the pathogenesis of KD and its complication of coronary artery lesion.
方法：对30名川崎病患儿和60名对照组儿童经基因测序分别进行CRP基因+1059位点、-757位点、-717位点基因突变的检测。
结果：①KD组CRP基因+1059G/C多态性位点的GG、GC基因型分布频率和G、C等位基因频率与正常对照组比较无显著性差异(χ2=0.038、0.034,P>0.05)；合并冠脉损伤者与无冠脉损伤者基因型分布频率和等位基因频率比较亦无显著性差异(P＞0.05)。②KD组CRP基因-757T/C多态性位点的TT、TC、CC基因型分布频率和T、C等位基因频率与正常对照组比较无显著性差异(χ2=2.893、2.500,P>0.05)；合并冠脉损伤者与无冠脉损伤者基因型分布频率和等位基因频率比较亦无显著性差异(P>0.05)；③KD组CRP基因-717A/G多态性位点的AA、AG基因型分布频率和A、G等位基因频率与正常对照组比较无显著性差异(χ2均=0,P>0.05)。合并冠脉损伤者与无冠脉损伤组基因型分布频率和等位基因频率比较亦无显著性差异(P>0.05)。
结论：CRP基因的+1059G/C位点、-757T/C位点、-717A/G位点多态性与川崎病及其冠状动脉损害的发生均无明显关联性。
Objective To investigate the relationship between the genetic polymorphisms of C-reactive protein(CRP) and children with Kawasaki Disease (KD) and that complicated with coronary artery lesion (CAL).
Method Gene sequence analysis was employed to confirm the mutational sites at+1059、-757 and -717 of C-reactive protein in 30 cases of children with KD and 60 healthy children as controls group respectively.
Results①As for the+1059G/C locus of CRP gene, there were no significant differences between genotype frequency of GG and GC types in KD and healthy controls (χ2=0.038, P>0.05); there was no significant differences between allele frequency of G and C type in KD and controls(χ2=0.034, P>0.05); there were no significant differences between the frequeneies of genotype and allele of KD complicated with CAL and without CAL (all P>0.05).②For the-757T/C locus of CRP gene, there were no significant differences between genotype frequency of TT、TC and CC types in KD and healthy controls (χ2=2.893, P>0.05); there was no significant differences between allele frequeney of T and C type in KD and controls (χ2=2.500, P>0.05); there were no significant differences between the frequeneies of genotype and allele of KD complicated with CAL ang without CAL((P＞0.05).③For the-717A/G locus of CRP gene, there were no significant differences between genotype frequency of AA and AG types in KD and healthy controls(x2=0, P>0.05); there was no significant differences between allele frequeney of A and G type in KD and controls(χ2=0, P>0.05); there were no significant differences between the frequeneies of genotype and allele of KD complicated with CAL ang without CAL((P>0.05).
Conclusion:The polymorphisms of +1059G/C、-757T/C、-717A/G locus of CRP gene had not been found association with the pathogenesis of KD and its complication of coronary artery lesion.
引文
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