PPARGC1及其辅激活基因多态性与有氧运动能力的关联性研究
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摘要
探讨PPARGC1及其辅激活基因NRF1、NRF2、TEAM的多态性与有氧运动能力的关联性。
研究一:PPARGC1及其辅激活基因多态性与杰出有氧运动能力的关联性研究
研究对象:123名长跑运动员和206名普通人
研究方法:通过case-control studies分析PPARGC1基因Thr394Thr、Gly482Ser、A2962G;NRF1基因rs2302970、rs6949152、rs10500120;NRF2基因rs12594956、rs80311031、rs7181866;TFAM基因rs1937、rs2306604、rs1049432多态性在运动员组与对照组的分布特征。
研究结果:A2962G与杰出有氧运动能力关联,并有性别差异。A等位基因的频率在女国际健将组显著高于女对照组,且女运动员组无GG基因型。G等位基因(AG+GG基因型)的频率在男运动员组显著高于男对照组。PPARGC1基因单体型与男子的杰出有氧运动能力关联,ACA单体型仅在男国际健将组存在,ACG单体型的分布频率在男国际健将组显著高于男对照组。
研究二:PPARGC1及其辅激活基因多态性与有氧运动能力表型的关联性研究
研究对象:102名汉族男性青年
研究方法:通过cross-sectional association studies和association studieswith training response phenotypes探讨上述多态性与有氧能力表型的关联性。
研究结果:1)A2962G与V02max初始值关联,携带G等位基因(AG+GG基因型)群体大于非携带者。2)rs80311031的CC基因型跑节省化的初始能力最强;NRF2基因ATG单体型跑节省化的初始能力最差,但训练敏感性最高;rs2302970的CT基因型,rs6949152的AG基因型初始能力最强,训练敏感性也最高。
结论:1)PPARGC1基因A2962G多态性及该基因单体型可作为男子长跑运动员选材用分子遗传学标记;2)A2962G、rs2402970、rs6949152和NRF2基因单体型可作为预测部分有氧运动能力表型的分子遗传学标记。
The aim of this work was to examine the association between the polymorphisms in PPARGC1,NRF1,NRF2 and TFAM gene and aerobic performance.
PartⅠ:Association study of PPARGC1 and coactivator genes with elite aerobic performance
Subjects:123 endurance athletes and 206 controls
Methods:The case-control studies were to analyze the gene polymorphisms characteristic between endurance athletes and controls.These polymorphisms were located in PPARGC1(Thr394Thr,Gly482Ser,A2962G), NRF1(rs2302970,rs6949152,rs10500120),NRF2(rs12594956,rs80311031, rs7181866) and TFAM(rs1937,rs2306604,rs1049432) gene.
Results:A2962G polymorphism was associated with elite aerobic performance with sexual difference.The frequency of G allele was significantly higher in elite male endurance athletes than male controls, while the A allele frequency was significantly higher in elite female athletes than female controls.Meantime,the PPARGC1 gene ACA haplotype was only appeared in elite male athletes,and the ACG haplotype frequency was significantly higher in elite male athletes than male controls.
PartⅡ:Association study of PPARGC1 and coactivator genes with aerobic phenotypes
Subjects:102 healthy,biologically unrelated young males from Northern China(of Han origin)
Methods:The cross-sectional association studies and association studies with training response phenotypes were used to explore the genetic markers for aerobic phenotypes,such as VO2max,running economy,left cardiac structure and function at baseline and in response to training.
Results:1) A2962G polymorphism was associated with VO2max at baseline, as carriers of the G allele(AG+GG genotypes) had higher levels of VO2max than the AA group.2) The VO2 at RE was associated with rs80311031, rs2302970 and NRF2 haplotype at baseline,whose carried CC,CT genotype or ATG haplotype had higher running economy capacity,respectively. However,the training response of VO2 at RE was associated with rs6949152, rs2302970 and NRF2 haplotype,and the group with AG,CT genotype or ATG haplotype were higher.
Conclusion:1) A2962G and PPARGC1 gene haplotype might be the genetic markers in predicting male elite athlete.2) A2962G,rs2402970,rs6949152 and NRF2 gene haplotype might be the genetic markers in predicting the aerobic phenotypes.
研究一:PPARGC1及其辅激活基因多态性与杰出有氧运动能力的关联性研究
研究对象:123名长跑运动员和206名普通人
研究方法:通过case-control studies分析PPARGC1基因Thr394Thr、Gly482Ser、A2962G;NRF1基因rs2302970、rs6949152、rs10500120;NRF2基因rs12594956、rs80311031、rs7181866;TFAM基因rs1937、rs2306604、rs1049432多态性在运动员组与对照组的分布特征。
研究结果:A2962G与杰出有氧运动能力关联,并有性别差异。A等位基因的频率在女国际健将组显著高于女对照组,且女运动员组无GG基因型。G等位基因(AG+GG基因型)的频率在男运动员组显著高于男对照组。PPARGC1基因单体型与男子的杰出有氧运动能力关联,ACA单体型仅在男国际健将组存在,ACG单体型的分布频率在男国际健将组显著高于男对照组。
研究二:PPARGC1及其辅激活基因多态性与有氧运动能力表型的关联性研究
研究对象:102名汉族男性青年
研究方法:通过cross-sectional association studies和association studieswith training response phenotypes探讨上述多态性与有氧能力表型的关联性。
研究结果:1)A2962G与V02max初始值关联,携带G等位基因(AG+GG基因型)群体大于非携带者。2)rs80311031的CC基因型跑节省化的初始能力最强;NRF2基因ATG单体型跑节省化的初始能力最差,但训练敏感性最高;rs2302970的CT基因型,rs6949152的AG基因型初始能力最强,训练敏感性也最高。
结论:1)PPARGC1基因A2962G多态性及该基因单体型可作为男子长跑运动员选材用分子遗传学标记;2)A2962G、rs2402970、rs6949152和NRF2基因单体型可作为预测部分有氧运动能力表型的分子遗传学标记。
The aim of this work was to examine the association between the polymorphisms in PPARGC1,NRF1,NRF2 and TFAM gene and aerobic performance.
PartⅠ:Association study of PPARGC1 and coactivator genes with elite aerobic performance
Subjects:123 endurance athletes and 206 controls
Methods:The case-control studies were to analyze the gene polymorphisms characteristic between endurance athletes and controls.These polymorphisms were located in PPARGC1(Thr394Thr,Gly482Ser,A2962G), NRF1(rs2302970,rs6949152,rs10500120),NRF2(rs12594956,rs80311031, rs7181866) and TFAM(rs1937,rs2306604,rs1049432) gene.
Results:A2962G polymorphism was associated with elite aerobic performance with sexual difference.The frequency of G allele was significantly higher in elite male endurance athletes than male controls, while the A allele frequency was significantly higher in elite female athletes than female controls.Meantime,the PPARGC1 gene ACA haplotype was only appeared in elite male athletes,and the ACG haplotype frequency was significantly higher in elite male athletes than male controls.
PartⅡ:Association study of PPARGC1 and coactivator genes with aerobic phenotypes
Subjects:102 healthy,biologically unrelated young males from Northern China(of Han origin)
Methods:The cross-sectional association studies and association studies with training response phenotypes were used to explore the genetic markers for aerobic phenotypes,such as VO2max,running economy,left cardiac structure and function at baseline and in response to training.
Results:1) A2962G polymorphism was associated with VO2max at baseline, as carriers of the G allele(AG+GG genotypes) had higher levels of VO2max than the AA group.2) The VO2 at RE was associated with rs80311031, rs2302970 and NRF2 haplotype at baseline,whose carried CC,CT genotype or ATG haplotype had higher running economy capacity,respectively. However,the training response of VO2 at RE was associated with rs6949152, rs2302970 and NRF2 haplotype,and the group with AG,CT genotype or ATG haplotype were higher.
Conclusion:1) A2962G and PPARGC1 gene haplotype might be the genetic markers in predicting male elite athlete.2) A2962G,rs2402970,rs6949152 and NRF2 gene haplotype might be the genetic markers in predicting the aerobic phenotypes.
引文
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