喉癌下咽癌术后咽瘘防治
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摘要
目的
分析喉癌、下咽癌术后咽瘘的主要原因,根据分析结果提出相应预防措施。
方法
收集2009年1月1日到2011年1月1日期间,经郑州大学第一附属医院耳鼻喉科收治的198例喉癌下咽癌(包括187例喉癌和11例下咽癌)手术患者的完整病例资料,使用SPSS10.0软件进行统计学分析。
结果
187例喉癌患者术后18例(9.6%)发生咽瘘,11例下咽癌患者术后3例(27.3%)发生咽瘘。全组病例除1例梭形细胞软组织肉瘤外,其余197例均为喉(或下咽)鳞状细胞癌。统计学分析结果显示,咽瘘发生的主要影响因素有：是否合并糖尿病,有无术前放疗,喉切除术前是否行气管切开,肿瘤分期,手术方式,同期有无行颈淋巴结清扫以及术后48小时内体温是否持续高于37.5度。患者的年龄、性别,肿瘤生长部位及手术时间等与咽瘘的发生无统计学意义。资料表明合并糖尿病,术前接受放疗和气管切开,肿瘤Ⅲ期、Ⅳ期,行喉全切除和(或)下咽切除术,同期行颈淋巴结清扫,术后48小时内体温高于37.5度的患者术后并发咽瘘的几率明显大于无糖尿病,术前未行放疗和气管切开,肿瘤Ⅰ-Ⅱ期,行喉部分切除,未行颈淋巴结清扫术,术后体温无明显升高的患者。
结论
咽瘘发生的高危因素主要有以下几点：1、术前血红蛋白低于正常值；2、术前合并糖尿病；3、术前接受放疗；4、术前行气管切开；5、肿瘤Ⅲ期-Ⅳ期；6、行喉全切除(或包括下咽部分切除)术；7、同期行颈淋巴结清扫术；8、术后48小时内体温持续高于37.5度。
对于合并以上高危因素的喉癌、下咽癌患者,须于术前将其营养状况调整至最佳；术中严格把握手术适应症,尤其应规范颈淋巴结的处理,避免漏诊的同时应注意减少患者不必要的创伤；术后加强护理。如此才能最大限度的减少咽瘘发生,减轻患者的负担。
Purpose:
To explore the etiology, mechanism and prevention measures through analysis of the main cause of Pharyngo-cutaneous fistula after surgery of laryngeal carcinoma and hypopharyngeal carcinoma.
Methods:
Collecting complete medical records of 198 patients with laryngeal carcinoma and hypopharyngeal carcinoma (including 187 cases of laryngeal carcinoma and 11 of hypopharyngeal carcinoma) from 2009 to 2011 at Department of Otolaryngology, first Affiliated Hospital of Zhengzhou University and analyzing statistically by using of SPSS10.0.
Results:
Among the 187 cases of laryngeal carcinoma,18 cases (9.6%) were Pharyngo-cutaneous fistula after operation and 3 in 11 cases (27.3%) of hypopharyngeal carcinoma. Except of the only 1 cases of spindle cells of soft tissue sarcomas, the rest of 197 are larynx (or swallow) squamous cell carcinoma. According to the statistical analysis results, the predominant influencing factors in the causation of Pharyngo-cutaneous fistula are tumor stage and operation method. Meanwhile, whether patients have merger diabetes, preoperative radiation, lower hemoglobin level, tracheotomy and lymph node dissection before survey as well as the temperature is over 37.5 degrees after survey do affect the results. It doesn't have any statistical significance about the patient's age, gender, tumor growth parts and operation time. Data shows that patients who have lower hemoglobin level, merger diabetes, preoperative radiation, tracheotomy and lymph node dissection before survey and got temperature over 37.5 degrees after survey risk greater complication than those without the treatment.
Conclusion:
High-risk factors for Pharyngo-cutaneous fistula following main points:1, lower preoperative hemoglobin level; 2, revealed diabetes mellitus; 3, Previous radiotherapy; 4, prior tracheotomy; 5, tumor stageⅢ～Ⅳ; 6, total laryngectomy 7, lymph node dissection; 8, temperature over 37.5 degrees within 48h.
For these patients, we must determine preoperative nutritional status will be adjusted to the best of them; strictly control surgical indications; postoperative intensive care. Only in this way, it is possible reduce the occurrence of Pharyngo-cutaneous fistula, reduce the burden on patients.
分析喉癌、下咽癌术后咽瘘的主要原因,根据分析结果提出相应预防措施。
方法
收集2009年1月1日到2011年1月1日期间,经郑州大学第一附属医院耳鼻喉科收治的198例喉癌下咽癌(包括187例喉癌和11例下咽癌)手术患者的完整病例资料,使用SPSS10.0软件进行统计学分析。
结果
187例喉癌患者术后18例(9.6%)发生咽瘘,11例下咽癌患者术后3例(27.3%)发生咽瘘。全组病例除1例梭形细胞软组织肉瘤外,其余197例均为喉(或下咽)鳞状细胞癌。统计学分析结果显示,咽瘘发生的主要影响因素有：是否合并糖尿病,有无术前放疗,喉切除术前是否行气管切开,肿瘤分期,手术方式,同期有无行颈淋巴结清扫以及术后48小时内体温是否持续高于37.5度。患者的年龄、性别,肿瘤生长部位及手术时间等与咽瘘的发生无统计学意义。资料表明合并糖尿病,术前接受放疗和气管切开,肿瘤Ⅲ期、Ⅳ期,行喉全切除和(或)下咽切除术,同期行颈淋巴结清扫,术后48小时内体温高于37.5度的患者术后并发咽瘘的几率明显大于无糖尿病,术前未行放疗和气管切开,肿瘤Ⅰ-Ⅱ期,行喉部分切除,未行颈淋巴结清扫术,术后体温无明显升高的患者。
结论
咽瘘发生的高危因素主要有以下几点：1、术前血红蛋白低于正常值；2、术前合并糖尿病；3、术前接受放疗；4、术前行气管切开；5、肿瘤Ⅲ期-Ⅳ期；6、行喉全切除(或包括下咽部分切除)术；7、同期行颈淋巴结清扫术；8、术后48小时内体温持续高于37.5度。
对于合并以上高危因素的喉癌、下咽癌患者,须于术前将其营养状况调整至最佳；术中严格把握手术适应症,尤其应规范颈淋巴结的处理,避免漏诊的同时应注意减少患者不必要的创伤；术后加强护理。如此才能最大限度的减少咽瘘发生,减轻患者的负担。
Purpose:
To explore the etiology, mechanism and prevention measures through analysis of the main cause of Pharyngo-cutaneous fistula after surgery of laryngeal carcinoma and hypopharyngeal carcinoma.
Methods:
Collecting complete medical records of 198 patients with laryngeal carcinoma and hypopharyngeal carcinoma (including 187 cases of laryngeal carcinoma and 11 of hypopharyngeal carcinoma) from 2009 to 2011 at Department of Otolaryngology, first Affiliated Hospital of Zhengzhou University and analyzing statistically by using of SPSS10.0.
Results:
Among the 187 cases of laryngeal carcinoma,18 cases (9.6%) were Pharyngo-cutaneous fistula after operation and 3 in 11 cases (27.3%) of hypopharyngeal carcinoma. Except of the only 1 cases of spindle cells of soft tissue sarcomas, the rest of 197 are larynx (or swallow) squamous cell carcinoma. According to the statistical analysis results, the predominant influencing factors in the causation of Pharyngo-cutaneous fistula are tumor stage and operation method. Meanwhile, whether patients have merger diabetes, preoperative radiation, lower hemoglobin level, tracheotomy and lymph node dissection before survey as well as the temperature is over 37.5 degrees after survey do affect the results. It doesn't have any statistical significance about the patient's age, gender, tumor growth parts and operation time. Data shows that patients who have lower hemoglobin level, merger diabetes, preoperative radiation, tracheotomy and lymph node dissection before survey and got temperature over 37.5 degrees after survey risk greater complication than those without the treatment.
Conclusion:
High-risk factors for Pharyngo-cutaneous fistula following main points:1, lower preoperative hemoglobin level; 2, revealed diabetes mellitus; 3, Previous radiotherapy; 4, prior tracheotomy; 5, tumor stageⅢ～Ⅳ; 6, total laryngectomy 7, lymph node dissection; 8, temperature over 37.5 degrees within 48h.
For these patients, we must determine preoperative nutritional status will be adjusted to the best of them; strictly control surgical indications; postoperative intensive care. Only in this way, it is possible reduce the occurrence of Pharyngo-cutaneous fistula, reduce the burden on patients.
引文
[1]郭玉德,杨和钧.妇女喉癌[J].国外医学.耳鼻咽喉科学分册,1978,(1)：35
[2]王立志,张秀珍.25915例恶性肿瘤某些自然因素的统计分析[J].吉林医科大学学报,1976,3：61-66
[3]朴美兰.2666例耳鼻咽喉肿瘤的临床分析[D].[硕士学位论文].吉林：吉林大学,2010
[4]何晓光.现代喉癌研究及诊治状况[J].昆明医学院学报,2010,(12)：12
[5]屠规益,胡郁化.下咽癌的外科治疗[J].中华耳鼻咽喉科杂志,1986,12：85-87
[6]周梁,陶磊.喉癌及下咽癌手术治疗进展[J].临床耳鼻咽喉头颈外科杂志,2007,21(14)：625-629
[7]Laccourretye O, Brasun D, Bassot V, et al. Cisplatin fluorourcil exclusive chemotherapy for T1-T3N0 glottic squamous cell carcinoma complete clincal reaponders:five-year results[J]. J Clin Oncol,1996,14:2331-2338
[8]Muller D, Millon R, Lideyeau K, et al. Frequent amplification of 11ql3 DNA markers is associated with lymph node involvement in human head and neck squamous cell carcinoma[J]. Eur J Cancer,1994,2:113-120
[9]王天铎,下咽癌的手术治疗现状[J].临床耳鼻咽喉科杂志,2000,14(6)：243-245
[10]吴学愚.耳鼻咽喉科全书-喉科学.第二版[M].上海：上海科学技术出版社,2000.295
[11]Bailey BJ, Biller HF. Surgery of the larynx [M]. Philadelphia:WB Saunders, Co, 1999.328-329.
[12]Cavalot AL, Gervasio CF, Nazionale G, et al. Pharyngocutaneous fistula as a complica-tion of total laryngectomy:review of the literature and analysis of case records[J]. Otolaryngol Head Neck Surg,2000,123:587-592
[13]Herranz J, Sarandeses A, Fernandez MF, et al. Complications after total laryngectomy in nonradiated laryngeal and hypopharyngeal carcinomas [J]. Otolaryngol Head Neck Surg,2000,122:892-898
[14]季文樾,惠莲,潘子民.喉全切除术后咽瘘的预防[J].临床耳鼻咽喉科杂志,1999,13(9)：422
[15]张智风,王蜡香.70例全喉切除术喉咽瘘形成原因分析及防治[J].中原医刊,1999,26：47
[16]Natvig K, Boysen M, Tausjo J. Tausjy J. Fistulae following laryngectomy in patients treated with irradiation[J]. J Laryngol Otol,1993,107:1136-1139
[17]De Zinis L, Tomenzoli D, Nicolai P. Postlaryngectomy pharyngocutaneous fistula: incidence, predisposing factors, and therapy. Head Neck,1999,21:131-138
[18]D Milisavljevic, M Stankovic, M Zivic, et al. Factors affecting results of treatment of Hypopharyngeal Carcinoma[J]. Hippokratia,2009,13 (3):154-160
[19]Boyce SE, Meyers AD. Oral feeding after total laryngectomy [J]. Head Neck, 1989,11:269-273
[20]Smith TJ, Burrage KJ, Ganguly P. Prevention of postlaryngectomy pharyngocutaneous fistula:The Memorial University experience[J]. Otolaryngol,2003,32:222-225
[21]黄选兆,汪吉宝.实用耳鼻咽喉头颈外科学.第二版[M].北京：人民卫生出版社,2008.490-511
[22]吴学愚.耳鼻咽喉科全书-喉科学.第二版[M].上海：上海科学技术出版社,2000.299-356
[23]杨占泉,董震.临床耳鼻咽喉-头颈外科学[M].长春：吉林大学出版社,2002.134
[24]黄选兆,汪吉宝.实用耳鼻咽喉头颈外科学.第二版[M].北京：人民卫生出版社,2008.660-665
[25]杨丽辉,郭星.喉切除术后咽瘘发生的相关因素[J].中国耳鼻咽喉头颈外科,2006,13(5)：277-280
[26]Makitie A, Irish J, Gullane P. Pharyngocutaneous fistula[J]. Curr Opin Otolaryngol Head Neck Surg,2003,11:78-84
[27]Paydarfar JA, Birkmeyer NJ. Complications in head and neck surgery:a meta-analysis of postlaryngectomy pharyngocutaneous fistula[J]. Arch Otolaryngol Head Neck Surg, 2006,132:67-72
[28]Antti A. Makitie, Riina Niemensivu, et al. Pharyngocutaneous fistula following total laryngectomy:a single institution's 10-year experience[J]. Eur Arch Otorhinolaryngol, 2006,263:1127-1130
[29]Parikh SR, Irish JC, Curran AJ, et al. Pharyngocutaneous fistula in laryngectomy patients; the Toronto Hospital experience[J]. J Otolaryngol,1998,27:136-140
[30]Redaelli de Zinis LO, Ferrari L, Tomenzoli D, et al. Postlaryngectomy pharyngocutaneous fistula:incidence, predisposing factors, and therapy[J]. Head Neck,1996,21:131-138
[31]Schwartz SR, Yueh B, Maynard C, et al. Predictors of wound complications after laryngectomy:A study of over 2000 patients[J]. Otolaryngol Head Neck Surg,2004,131: 61-68
[32]van Bokhorst-de van der Schueren M, van Leeuwen PAM, Sauerwein HP, et al. Assess-ment of malnutrition parameters in head and neck cancer and their relation to postoperative complications[J]. Head Neck,1997,19:419-425
[33]王海明,徐凌,李松林.老年大手术病人术前营养支持治疗的意义[C].浙江省肠外肠内营养学学术会议论文集,2007
[34]Cavalot AL, Gervasio CF, Nazionale G, et al. Pharyngocutaneous fistula as a complication of total laryngectomy:review of the literature, analysis of case records[J]. Otolaryngol Head Neck Surg,2000,123:587-592
[35]Jovanovic M, Perovic J, Grubor A. The impact of diabetes mellitus on postoperative morbidity in laryngeal surgery[J]. Acta Chir Iugosl,2006,53:51-55
[36]Genden EM, Rinaldo A, Shara AR. et al. Pharyngocutaneous fistula following laryngectomy [J]. Acta Otolaryngol,2004,124:117-120
[37]Cavalot AL, Gervasio CF, Nazionale G, et al. Pharyngocutaneous fistula as a complication of total laryngectomy:review of the literature and analysis of case records [J]. Otolaryngol Head Neck Surg,2000,123:587-592
[38]Tsou YA, Hua CH, Lin MH, et al. Comparison of pharyngocutaneous fistula between patients followed by primary laryngopharyngectomy and salvage laryngopharyngectomy for advanced hypopharyngeal cancer[J]. Head Neck,2010,32 (11):1494-500
[39]申文江,王绿化.放射治疗损伤[M].北京：中国医学科技出版社,2001,66-81
[40]Hier M, Black M J, Lafond G. Pharyngo-cutaneous fistulas after total laryngectomy: Incidence, etiology and outcome analysis[J]. J Otolaryngol,1997,22:164-166
[41]Dirven R, Swinson BD, Gao K, et al. The assessment of pharyngocutaneous fistula rate in patients treated primarily with definitive radiotherapy followed by salvage surgery of the larynx and hypopharynx[J]. Laryngoscope.2009,119 (9):1691-1695
[42]Markou KD, Vlachtsis KC, Nikolaou AC, et al. Incidence and predisposing factors of pharyngocutaneous fistula formation after total laryngectomy. Is there a relationship with tumor recurrence[J]? Eur Arch Otorhinolaryngol,2004,261:61-67
[43]Galli J, De Corso E, Volante M, et al. Postlaryngectomy pharyngocutaneous fistula: incidence, predisposing factors, and therapy[J]. Otolaryngol Head Neck Surg,2005,133: 689-694
[44]Makitie AA, Niemensivu R, Hero M, et al. Pharyngocutaneous fistula following total laryngectomy:a single institution's 10-year experience[J]. Eur Arch Otorhinolaryngol, 2006,263:1127-1130
[45]Morton RP, Mehanna H, Hall FT, Mclvor NP. Prediction of pharyngocutaneous fistulas after laryngectomy [J]. Otolaryngol Head Neck Surg,2007,136:46-49
[46]邓青南,郭振辉.老年呼吸系统急危重症学[M].北京：人民军医出版社,2009：8-9
[47]谢正福,刘唐威,施焕中.内科重症监护学[M].北京：科学出版社,2006：98
[48]Soylu L, Kiroglu M, Aydogan B, et al. Pharyngocutaneous fistula following laryngectomy[J]. Head Neck,1998,20:22-25
[49]Harrison DFN, Thompson AE. Pharyn golaryn-goesophagectomy with pharyngogastric anastomosis for cancer of the hypopharynx,Review of 101 operations[J]. Head Neck Surg,1985,8:418
[50]杨凯,温玉明.颈淋巴结清扫术100年回顾与展望[J].临床口腔医学杂志,2005,10(21)：634-637
[51]Pinar E, Oncel S, Calli C, Guclu E, Tatar B. Pharyngo-cutaneous fistula after total laryngectomy:emphasis on lymph node metastases as a new predisposing factor [J]. J Otolaryngol Head Neck Surg,2008,37:312-318
[52]Galli J, De-Corso E, Volante M, et al. Postlaryngectomy pharyngocutaneous fistula incidence, predisposing factors, and therapy [J]. Otolaryngol Head Neck Surg,2005, 133(2):689-694
[53]Markou KD, Vlachtsis KC, Nikolaou AC, et al. Incidence and predisposing factors of pharyngocutaneous fistula formation after total laryngectomy. Is there a relationship with tumor recurrence[J]? Eur Arch Otorhinolaryngol,2004,261:61-67
[54]Friedman M, Venkatesan TK, Yakovlev A, et al. Early detection and treatment of postoperative pharyngocutaneous fistula[J]. Otolaryngol Head Neck Surg,1999,121: 378-380
[55]de Melo GM, Ribeiro KC, Kowalski LP, et al. Risk factors for postoperative complications in oral cancer and their prognostic implications[J]. Arch Otolaryngol Head Neck Surg, 2001,127:828-833
[56]Zabrodsky M, Calabrese L, Tosoni A. et al. Major surgery in elderly head and neck cancer patients:immediate and longterm surgical results and complication rates[J]. Surg Oncol, 2004,13:249-255
[57]Balbuena L, Stambaugh KI, Ramirez SG, et al. Effects of topical oral antiseptic rinses on bacterial counts of saliva in healthy human subjects[J]. Otolaryngol Head Neck Surg,1998,118:625-629
[1]Celikkanat S, Koc C, Ozdem C. Effect of blood transfusion on tumor recurrence and postoperative pharyngocutaneous fistula formation in patients subjected to total laryngectomy[J]. Acta Otolaryngol,1995,115:566-568
[2]Qureshi SS, Chaturvedi P, Pai PS, et al. A prospective study of pharyngocutaneous fistulas following total laryngectomy[J]. J Cancer Res Ther,2005,1:51-56
[3]Boscolo-Rizzo P, De Cillis G, Marchiori C, et al. Multivariate analysis of risk factors for pharyngocutaneous fistula after total laryngectomy[J]. Eur Arch Otorhinolaryngol,2008, 265:929-936
[4]Natvig K, Boysen M, Tausj(?) J, et al. Fistulae following laryngectomy in patients treated with irradiation[J]. J Laryngol Otol,1993,107:1136-1139
[5]De Zinis L, Tomenzoli D, Nicolai P. Postlaryngectomy pharyngocutaneous fistula: incidence, predisposing factors, and therapy [J]. Head Neck,1999,21:131-138
[6]Brookes GB. Nutritional status-a prognostic indicator in head and neck cancer[J]. Otolaryngol Head Neck Surg,1985,93:69-74
[7]van Bokhorst-de van der Schueren M, van Leeuwen PAM, Sauerwein HP, et al. Assessment of malnutrition parameters in head and neck cancer and their relation to postoperative complications[J]. Head Neck,1997,19:419-425
[8]Martin Villares C, Pomar P, Iglesias M C, et al. Predictive biochemical indicators of postlaryngectomy pharyngocutaneous fistula:a clinical study[J]. Acta Otorrinolaringol Esp, 2005,56:140-144
[9]Heys SD, Ogston KN. Peri-Operative nutritional support:controversies and debates [J]. Int J Surg Investig,2000,2 (2):107-115
[10]Seth R, Schwartz MD, Bevan Yueh MD, et al. Predictors of wound complications after laryngectomy:A study of 2000 patients[J]. Otolaryngology-Head and Neck Surgery,2004, 131(1):61-68
[11]Hahn SS, Spaulding CA, Kim JA, et al. The prognostic significance of lymph node involvement in pyriform sinus and supraglottic cancers [J]. Int J Radiat Oncol Biol Phys, 1987,13:1143
[12]Nader Saki MD, Soheila Nikakhlagh MD, Maryam Kazemi MD. Pharyngocutaneous fistula after Laryngectomy:Incidence, Predisposing Factors, and Outcome[J]. Arch Iranian Med,2008,11 (3):314-317
[13]C.Righini, T.Lequeux, O.Cuisnier. The pectoralis myofascial flap in pharyngolaryngeal surgery after radiotherapy [J]. Eur Arch Otorhinolaryngol,2005,262:357-361
[14]Dirven R, Swinson BD, Gao K, et al. The assessment of pharyngocutaneous fistula rate in patients treated primarily with definitive radiotherapy followed by salvage surgery of the larynx and hypopharynx[J]. Laryngoscope,2009,119 (9):1691-1695
[15]Makitie AA, Niemensivu R, Hero M, et al. Pharyngocutaneous fistula following total laryngectomy:a single institution's 10-year experience[J]. Eur Arch Otorhinolaryngol, 2006,263:1127-1130
[16]Morton RP, Mehanna H, Hall FT, McIvor NP. Prediction of pharyngocutaneous fistulas after laryngectomy[J]. Otolaryngol Head Neck Surg,2007,136:46-49
[17]Paolo Boscolo-Rizzo, Giuseppe De Cillis, Carlo Marchiori. Multivariate analysis of risk factors for pharyngocutaneous fistula after total laryngectomy [J]. Eur Arch Otorhinolaryngol,2008,265:929-936
[18]Friberg D, Lundberg C. Antibiotics prophylaxis in major head and neck surgery when clean-contaminated wounds are established[J]. Scand J Infect Dis Suppl,1990,70:87-90
[19]SCOLA B, FERNANDEZ-VEGA M, MARTINEZ T, et al. Management of cancer of the supraglottis [J]. Otolaryngol Head Neck Surg,2001,124:195-199
[20]屠规益.颈淋巴系统[J].中华耳鼻咽喉科杂志,1991,26：372-374
[21]Cabanas RM. An approach for the treatment of the penile carcinoma[J]. Cancer,1977,39: 456-466
[22]李野.cN0期喉癌颈淋巴结隐匿性转移的前瞻性研究[D].[博士学位论文].吉林：吉林大学,2004
[23]王天铎,下咽癌的手术治疗现状[J].临床耳鼻咽喉科杂志,2000,14(6)：243-245
[24]于湛,佟欣,赵鸿.防止喉癌术后咽瘘的围手术期处理[J].中国肿瘤临床与康复,2006,13(5)：479～480
[25]Smith TJ, Burrage KJ, Ganguly P. Prevention of postlaryngectomy pharyngocutaneous fistula:The Memorial University experience[J]. Otolaryngol,2003,32:222-225
[26]Grau C, Johansen LV, Hansen HS, et al. Salvage laryngectomy and pharyngocutaneous fistulae after primary radiotherapy for head and neck cancer:a national survey from DAHANCA[J]. Head Neck,2003,25:711-716
[27]Markou KD, Vlachtsis KC, Nikolaou AC, et al. Incidence and predisposing factors of pharyngocutaneous fistula formation after total laryngectomy. Is there a relationship with tumor recurrence[J]? Eur Arch Otorhinolaryngol,2004,261:61-67
[28]Pinar E, Oncel S, Calli C, Guclu E, Tatar B. Pharyngo-cutaneous fistula after total laryngectomy:emphasis on lymph node metastases as a new predisposing factor [J]. J Otolaryngol Head Neck Surg,2008,37:312-318
[29]Moy RL, Waldman B, Hein DW. A review of sutures and suturing techniques[J]. J Dermatol Surg Oncol,1992,18:785-95
[30]Olutoye OO, Zhu X, Cass DL, et al. Neutrophil recruitment by fetal porcine endothelial cells:implications in scarless fetal wound healing[J]. Pediatr Res,2005,58:1290-1294
[31]戴朴,杨仕明,等.喉切除术后咽瘘的预防和治疗[J].中国耳鼻咽喉头颈外科杂志,2004,11(4)：205～206
[32]吴建烽,吴正虎.预防喉及下咽癌术后咽瘘发生的经验[J].浙江中医药大学学 报,2008,32(6)：754-755
[33]苏志文,宋新汉.喉癌术后咽瘘原因分析及预防[J].实用医学杂志,1995,11(6)：357-358
[34]韦正波,谢莹,等.喉全切除术后咽瘘影响因素的Meta分析[J].中国耳鼻咽喉头颈外科,2007,14(10)：563-566
[35]Goncalves A J, de Souza JA Jr, Menezes M B, et al. Pharyngocutaneous fistulae following total laryngectomy comparison between manual and mechanical sutures [J]. Eur Arch Otorhinolaryngol,2009,266 (11):1973-1978
[36]Lukyanchenko AG. Suturing of a laryngeal defect in laryngectomy [J]. Vestn Otorinolaringol,1971,33:29-30
[37]Antonio Jose Goncalves, J.A.L.de Souza Jr, M.B.Menezes, et al. Pharyngocutaneous fistulae following total laryngectomy comparison between manual and mechanical sutures[J]. Eur Arch Otorhinolaryngol,2009,266:1793-1798
[38]Montoya FS, Galarreta JCR, Del Rey AS, et al. Comparative study between the use of manual versus mechanical sutures in the closing of the mucous defect following a total laryngectomy[J]. Acta Otorrinolaringol Esp,2002,53:343-350
[39]Weiss LS, Miller RH, Bates ML, et al. An animal model for pharyngocutaneous fistulas[J]. Otolaryngol Head Neck Surg,1993,108:738-742
[40]Qureshi S S, Chaturvedi P, Pai P S, et al. A prospective study of phryngocutaneous fistulas follow ing total laryngectomy[J]. J Cancer Res Ther,2005,3:51-56
[41]Patel UA, Keni SP. Pectoralis myofascial flap during salvage laryngectomy prevents pharyngocutaneous fistula[J]. Otolaryngol Head Neck Surg,2009,141 (2):190-195
[42]路学美,张素华.颈阔肌肌筋膜瓣行喉重建的疗效观察[J].现代诊断与治疗,1997,8(5)：275-277
[43]谢允平,冉骞,阙镇如.双蒂颈前带状肌肌瓣在喉癌术后喉功能重建中的应用[J].实用医学杂志,2007,23(16)：2569-2570
[44]Hin-Lun Liu, Jimmy Yu-Wai Chan, William Ignace Wei. The changing role of pectoralis major flap in head and neck reconstruction[J]. Eur Arch Otorhinolaryngol,2010,267: 1759-1763
[45]Young-Hoon Joo, Dong-Il Sun, Jun-Ook Park, et al. Factors predicting fistula following radial forearm free flap reconstruction for head and neck cancer [J]. Oral Oncology, 2010,46:684-687
[46]陈志俊,孙彦,华辉.会厌瓣和胸骨舌骨肌肌筋膜瓣在喉癌喉部分切除喉功能重建中的应用[J].临床耳鼻咽喉科杂志,2005,19(15)：692-694
[47]de Bree R, Reith R, Quak JJ, et al. Free radial forearm flap versus pectoralis major myocutaneous flap reconstruction of oral and oropharyngeal defects:a cost analysis[J]. Clin Otolaryngol,2007,32:275-282
[48]季文樾,惠莲,潘子民,等.喉全切除术后咽瘘的预防[J].临床耳鼻喉科杂志,1999,13(9)：422
[49]谢正福,刘唐威,施焕中.内科重症监护学[M].北京：科学出版社,2006：98
[50]杨春华,孙玉霞,陆平静,等.喉癌术后病人的营养支持[J].中华护理杂志,2001,36(1)：16-18
[51]McCarter MD, Gomez ME, Daly JM. Ealy Postoperative enteral feeding following major upper gastrointestinal surgery [J]. Gastrointest Surg,1997,1:278-285
[52]冯威.喉癌术后患者留置胃管鼻饲与食道反流的探讨[A].中华护理学会2009全国五官科护理学术交流暨专题讲座会议论文汇编[C],2009,78-79
[53]Seikaly H, Park P. Gastroesophageal reflux prophylaxis decreases the incidence of pharyngocutaneous fistula after total laryngectomy[J]. Laryngoscope,1995,105:1220-1222
[54]Seven h, Calis AB, Turgut S. A randomized controlled trial of early oral feeding on laryngectomized patients[J]. Laryngoscope,2003,113:1076-1079
[55]Rodriguez-Cuevas S, Labastida S, Gutierrez F, et al. Oral feeding after total laryngectomy for endolaryngeal cancer[J]. Eur Arch Otorhinolaryngol,1995,252:130-132
[56]Medina JE, Khafif A. Early oral feeding following total laryngectomy[J]. Laryngoscope 2001,111:368-372
[57]Saydam L, Kalcioglu T, Kizilay A. Early oral feeding following total laryngectomy[J]. Am J Otolaryngol,2002,23:277-281
[58]Galli J, De Corso E, Volante M, et al. Postlaryngectomy pharyngocutaneous fistula: incidence, predisposing factors, and therapy[J]. Otolaryngology-Head and Neck Surgery, 2005,133:689-694
[59]Tomkinson A, Shone GR, Dingle A. Pharyngocutaneous fistula following total laryngectomy and postoperative vomiting[J]. Clin Otolaryngol,1996,21:369-370
[60]Redaelli de Zinis LO, Ferrari L, Tomenzoli D, et al. Postlaryngectomy pharyngocutaneous fistula:incidence, predisposing factors, and therapy[J]. Head Neck,1999,21:131-138
[61]Virtaniemi JA, Kumpulainen EJ, Hirvikoski PP, et al. The incidence and etiology of postlaryngectomy pharyngocutaneous fistulae[J]. Head Neck,2001,23:29-33
[62]朱燕英,何金爱.运用湿性敷料配合封闭负压疗法治愈咽瘘患者一例[J].护士进修杂志,2010,25(11)：1021-1022
[63]祝小林,文卫平,蒋爱云.保守治疗咽瘘的临床转归研究[J].临床耳鼻咽喉头颈外科杂志,2008,22(23)：1079-1082
[64]Montgomery WW. Plastic esophageal tube[J]. Ann Otol Rhinol Laryngol,1955,64: 418-421
[65]Angela Lorken.MD, J.Krampert.MD, R.J.Kau,MD. Experiences with the Montgomery Salivary Bypass Tube (MSBT)[J]. Dysphagia,1997,12:79-83
[66]Berry SM, Fischer JE. Classification and pathophysiology of enterocutaneous fistulas [J]. Surg Clin North Am,1996,76:1009-1018
[67]Qureshi S S, Chaturvedi P, Pai P S, et al. A prospective study of phryngocutaneous fistulas follow ing total laryngectomy[J]. J Cancer Res Ther,2005,3:51-56
[2]王立志,张秀珍.25915例恶性肿瘤某些自然因素的统计分析[J].吉林医科大学学报,1976,3：61-66
[3]朴美兰.2666例耳鼻咽喉肿瘤的临床分析[D].[硕士学位论文].吉林：吉林大学,2010
[4]何晓光.现代喉癌研究及诊治状况[J].昆明医学院学报,2010,(12)：12
[5]屠规益,胡郁化.下咽癌的外科治疗[J].中华耳鼻咽喉科杂志,1986,12：85-87
[6]周梁,陶磊.喉癌及下咽癌手术治疗进展[J].临床耳鼻咽喉头颈外科杂志,2007,21(14)：625-629
[7]Laccourretye O, Brasun D, Bassot V, et al. Cisplatin fluorourcil exclusive chemotherapy for T1-T3N0 glottic squamous cell carcinoma complete clincal reaponders:five-year results[J]. J Clin Oncol,1996,14:2331-2338
[8]Muller D, Millon R, Lideyeau K, et al. Frequent amplification of 11ql3 DNA markers is associated with lymph node involvement in human head and neck squamous cell carcinoma[J]. Eur J Cancer,1994,2:113-120
[9]王天铎,下咽癌的手术治疗现状[J].临床耳鼻咽喉科杂志,2000,14(6)：243-245
[10]吴学愚.耳鼻咽喉科全书-喉科学.第二版[M].上海：上海科学技术出版社,2000.295
[11]Bailey BJ, Biller HF. Surgery of the larynx [M]. Philadelphia:WB Saunders, Co, 1999.328-329.
[12]Cavalot AL, Gervasio CF, Nazionale G, et al. Pharyngocutaneous fistula as a complica-tion of total laryngectomy:review of the literature and analysis of case records[J]. Otolaryngol Head Neck Surg,2000,123:587-592
[13]Herranz J, Sarandeses A, Fernandez MF, et al. Complications after total laryngectomy in nonradiated laryngeal and hypopharyngeal carcinomas [J]. Otolaryngol Head Neck Surg,2000,122:892-898
[14]季文樾,惠莲,潘子民.喉全切除术后咽瘘的预防[J].临床耳鼻咽喉科杂志,1999,13(9)：422
[15]张智风,王蜡香.70例全喉切除术喉咽瘘形成原因分析及防治[J].中原医刊,1999,26：47
[16]Natvig K, Boysen M, Tausjo J. Tausjy J. Fistulae following laryngectomy in patients treated with irradiation[J]. J Laryngol Otol,1993,107:1136-1139
[17]De Zinis L, Tomenzoli D, Nicolai P. Postlaryngectomy pharyngocutaneous fistula: incidence, predisposing factors, and therapy. Head Neck,1999,21:131-138
[18]D Milisavljevic, M Stankovic, M Zivic, et al. Factors affecting results of treatment of Hypopharyngeal Carcinoma[J]. Hippokratia,2009,13 (3):154-160
[19]Boyce SE, Meyers AD. Oral feeding after total laryngectomy [J]. Head Neck, 1989,11:269-273
[20]Smith TJ, Burrage KJ, Ganguly P. Prevention of postlaryngectomy pharyngocutaneous fistula:The Memorial University experience[J]. Otolaryngol,2003,32:222-225
[21]黄选兆,汪吉宝.实用耳鼻咽喉头颈外科学.第二版[M].北京：人民卫生出版社,2008.490-511
[22]吴学愚.耳鼻咽喉科全书-喉科学.第二版[M].上海：上海科学技术出版社,2000.299-356
[23]杨占泉,董震.临床耳鼻咽喉-头颈外科学[M].长春：吉林大学出版社,2002.134
[24]黄选兆,汪吉宝.实用耳鼻咽喉头颈外科学.第二版[M].北京：人民卫生出版社,2008.660-665
[25]杨丽辉,郭星.喉切除术后咽瘘发生的相关因素[J].中国耳鼻咽喉头颈外科,2006,13(5)：277-280
[26]Makitie A, Irish J, Gullane P. Pharyngocutaneous fistula[J]. Curr Opin Otolaryngol Head Neck Surg,2003,11:78-84
[27]Paydarfar JA, Birkmeyer NJ. Complications in head and neck surgery:a meta-analysis of postlaryngectomy pharyngocutaneous fistula[J]. Arch Otolaryngol Head Neck Surg, 2006,132:67-72
[28]Antti A. Makitie, Riina Niemensivu, et al. Pharyngocutaneous fistula following total laryngectomy:a single institution's 10-year experience[J]. Eur Arch Otorhinolaryngol, 2006,263:1127-1130
[29]Parikh SR, Irish JC, Curran AJ, et al. Pharyngocutaneous fistula in laryngectomy patients; the Toronto Hospital experience[J]. J Otolaryngol,1998,27:136-140
[30]Redaelli de Zinis LO, Ferrari L, Tomenzoli D, et al. Postlaryngectomy pharyngocutaneous fistula:incidence, predisposing factors, and therapy[J]. Head Neck,1996,21:131-138
[31]Schwartz SR, Yueh B, Maynard C, et al. Predictors of wound complications after laryngectomy:A study of over 2000 patients[J]. Otolaryngol Head Neck Surg,2004,131: 61-68
[32]van Bokhorst-de van der Schueren M, van Leeuwen PAM, Sauerwein HP, et al. Assess-ment of malnutrition parameters in head and neck cancer and their relation to postoperative complications[J]. Head Neck,1997,19:419-425
[33]王海明,徐凌,李松林.老年大手术病人术前营养支持治疗的意义[C].浙江省肠外肠内营养学学术会议论文集,2007
[34]Cavalot AL, Gervasio CF, Nazionale G, et al. Pharyngocutaneous fistula as a complication of total laryngectomy:review of the literature, analysis of case records[J]. Otolaryngol Head Neck Surg,2000,123:587-592
[35]Jovanovic M, Perovic J, Grubor A. The impact of diabetes mellitus on postoperative morbidity in laryngeal surgery[J]. Acta Chir Iugosl,2006,53:51-55
[36]Genden EM, Rinaldo A, Shara AR. et al. Pharyngocutaneous fistula following laryngectomy [J]. Acta Otolaryngol,2004,124:117-120
[37]Cavalot AL, Gervasio CF, Nazionale G, et al. Pharyngocutaneous fistula as a complication of total laryngectomy:review of the literature and analysis of case records [J]. Otolaryngol Head Neck Surg,2000,123:587-592
[38]Tsou YA, Hua CH, Lin MH, et al. Comparison of pharyngocutaneous fistula between patients followed by primary laryngopharyngectomy and salvage laryngopharyngectomy for advanced hypopharyngeal cancer[J]. Head Neck,2010,32 (11):1494-500
[39]申文江,王绿化.放射治疗损伤[M].北京：中国医学科技出版社,2001,66-81
[40]Hier M, Black M J, Lafond G. Pharyngo-cutaneous fistulas after total laryngectomy: Incidence, etiology and outcome analysis[J]. J Otolaryngol,1997,22:164-166
[41]Dirven R, Swinson BD, Gao K, et al. The assessment of pharyngocutaneous fistula rate in patients treated primarily with definitive radiotherapy followed by salvage surgery of the larynx and hypopharynx[J]. Laryngoscope.2009,119 (9):1691-1695
[42]Markou KD, Vlachtsis KC, Nikolaou AC, et al. Incidence and predisposing factors of pharyngocutaneous fistula formation after total laryngectomy. Is there a relationship with tumor recurrence[J]? Eur Arch Otorhinolaryngol,2004,261:61-67
[43]Galli J, De Corso E, Volante M, et al. Postlaryngectomy pharyngocutaneous fistula: incidence, predisposing factors, and therapy[J]. Otolaryngol Head Neck Surg,2005,133: 689-694
[44]Makitie AA, Niemensivu R, Hero M, et al. Pharyngocutaneous fistula following total laryngectomy:a single institution's 10-year experience[J]. Eur Arch Otorhinolaryngol, 2006,263:1127-1130
[45]Morton RP, Mehanna H, Hall FT, Mclvor NP. Prediction of pharyngocutaneous fistulas after laryngectomy [J]. Otolaryngol Head Neck Surg,2007,136:46-49
[46]邓青南,郭振辉.老年呼吸系统急危重症学[M].北京：人民军医出版社,2009：8-9
[47]谢正福,刘唐威,施焕中.内科重症监护学[M].北京：科学出版社,2006：98
[48]Soylu L, Kiroglu M, Aydogan B, et al. Pharyngocutaneous fistula following laryngectomy[J]. Head Neck,1998,20:22-25
[49]Harrison DFN, Thompson AE. Pharyn golaryn-goesophagectomy with pharyngogastric anastomosis for cancer of the hypopharynx,Review of 101 operations[J]. Head Neck Surg,1985,8:418
[50]杨凯,温玉明.颈淋巴结清扫术100年回顾与展望[J].临床口腔医学杂志,2005,10(21)：634-637
[51]Pinar E, Oncel S, Calli C, Guclu E, Tatar B. Pharyngo-cutaneous fistula after total laryngectomy:emphasis on lymph node metastases as a new predisposing factor [J]. J Otolaryngol Head Neck Surg,2008,37:312-318
[52]Galli J, De-Corso E, Volante M, et al. Postlaryngectomy pharyngocutaneous fistula incidence, predisposing factors, and therapy [J]. Otolaryngol Head Neck Surg,2005, 133(2):689-694
[53]Markou KD, Vlachtsis KC, Nikolaou AC, et al. Incidence and predisposing factors of pharyngocutaneous fistula formation after total laryngectomy. Is there a relationship with tumor recurrence[J]? Eur Arch Otorhinolaryngol,2004,261:61-67
[54]Friedman M, Venkatesan TK, Yakovlev A, et al. Early detection and treatment of postoperative pharyngocutaneous fistula[J]. Otolaryngol Head Neck Surg,1999,121: 378-380
[55]de Melo GM, Ribeiro KC, Kowalski LP, et al. Risk factors for postoperative complications in oral cancer and their prognostic implications[J]. Arch Otolaryngol Head Neck Surg, 2001,127:828-833
[56]Zabrodsky M, Calabrese L, Tosoni A. et al. Major surgery in elderly head and neck cancer patients:immediate and longterm surgical results and complication rates[J]. Surg Oncol, 2004,13:249-255
[57]Balbuena L, Stambaugh KI, Ramirez SG, et al. Effects of topical oral antiseptic rinses on bacterial counts of saliva in healthy human subjects[J]. Otolaryngol Head Neck Surg,1998,118:625-629
[1]Celikkanat S, Koc C, Ozdem C. Effect of blood transfusion on tumor recurrence and postoperative pharyngocutaneous fistula formation in patients subjected to total laryngectomy[J]. Acta Otolaryngol,1995,115:566-568
[2]Qureshi SS, Chaturvedi P, Pai PS, et al. A prospective study of pharyngocutaneous fistulas following total laryngectomy[J]. J Cancer Res Ther,2005,1:51-56
[3]Boscolo-Rizzo P, De Cillis G, Marchiori C, et al. Multivariate analysis of risk factors for pharyngocutaneous fistula after total laryngectomy[J]. Eur Arch Otorhinolaryngol,2008, 265:929-936
[4]Natvig K, Boysen M, Tausj(?) J, et al. Fistulae following laryngectomy in patients treated with irradiation[J]. J Laryngol Otol,1993,107:1136-1139
[5]De Zinis L, Tomenzoli D, Nicolai P. Postlaryngectomy pharyngocutaneous fistula: incidence, predisposing factors, and therapy [J]. Head Neck,1999,21:131-138
[6]Brookes GB. Nutritional status-a prognostic indicator in head and neck cancer[J]. Otolaryngol Head Neck Surg,1985,93:69-74
[7]van Bokhorst-de van der Schueren M, van Leeuwen PAM, Sauerwein HP, et al. Assessment of malnutrition parameters in head and neck cancer and their relation to postoperative complications[J]. Head Neck,1997,19:419-425
[8]Martin Villares C, Pomar P, Iglesias M C, et al. Predictive biochemical indicators of postlaryngectomy pharyngocutaneous fistula:a clinical study[J]. Acta Otorrinolaringol Esp, 2005,56:140-144
[9]Heys SD, Ogston KN. Peri-Operative nutritional support:controversies and debates [J]. Int J Surg Investig,2000,2 (2):107-115
[10]Seth R, Schwartz MD, Bevan Yueh MD, et al. Predictors of wound complications after laryngectomy:A study of 2000 patients[J]. Otolaryngology-Head and Neck Surgery,2004, 131(1):61-68
[11]Hahn SS, Spaulding CA, Kim JA, et al. The prognostic significance of lymph node involvement in pyriform sinus and supraglottic cancers [J]. Int J Radiat Oncol Biol Phys, 1987,13:1143
[12]Nader Saki MD, Soheila Nikakhlagh MD, Maryam Kazemi MD. Pharyngocutaneous fistula after Laryngectomy:Incidence, Predisposing Factors, and Outcome[J]. Arch Iranian Med,2008,11 (3):314-317
[13]C.Righini, T.Lequeux, O.Cuisnier. The pectoralis myofascial flap in pharyngolaryngeal surgery after radiotherapy [J]. Eur Arch Otorhinolaryngol,2005,262:357-361
[14]Dirven R, Swinson BD, Gao K, et al. The assessment of pharyngocutaneous fistula rate in patients treated primarily with definitive radiotherapy followed by salvage surgery of the larynx and hypopharynx[J]. Laryngoscope,2009,119 (9):1691-1695
[15]Makitie AA, Niemensivu R, Hero M, et al. Pharyngocutaneous fistula following total laryngectomy:a single institution's 10-year experience[J]. Eur Arch Otorhinolaryngol, 2006,263:1127-1130
[16]Morton RP, Mehanna H, Hall FT, McIvor NP. Prediction of pharyngocutaneous fistulas after laryngectomy[J]. Otolaryngol Head Neck Surg,2007,136:46-49
[17]Paolo Boscolo-Rizzo, Giuseppe De Cillis, Carlo Marchiori. Multivariate analysis of risk factors for pharyngocutaneous fistula after total laryngectomy [J]. Eur Arch Otorhinolaryngol,2008,265:929-936
[18]Friberg D, Lundberg C. Antibiotics prophylaxis in major head and neck surgery when clean-contaminated wounds are established[J]. Scand J Infect Dis Suppl,1990,70:87-90
[19]SCOLA B, FERNANDEZ-VEGA M, MARTINEZ T, et al. Management of cancer of the supraglottis [J]. Otolaryngol Head Neck Surg,2001,124:195-199
[20]屠规益.颈淋巴系统[J].中华耳鼻咽喉科杂志,1991,26：372-374
[21]Cabanas RM. An approach for the treatment of the penile carcinoma[J]. Cancer,1977,39: 456-466
[22]李野.cN0期喉癌颈淋巴结隐匿性转移的前瞻性研究[D].[博士学位论文].吉林：吉林大学,2004
[23]王天铎,下咽癌的手术治疗现状[J].临床耳鼻咽喉科杂志,2000,14(6)：243-245
[24]于湛,佟欣,赵鸿.防止喉癌术后咽瘘的围手术期处理[J].中国肿瘤临床与康复,2006,13(5)：479～480
[25]Smith TJ, Burrage KJ, Ganguly P. Prevention of postlaryngectomy pharyngocutaneous fistula:The Memorial University experience[J]. Otolaryngol,2003,32:222-225
[26]Grau C, Johansen LV, Hansen HS, et al. Salvage laryngectomy and pharyngocutaneous fistulae after primary radiotherapy for head and neck cancer:a national survey from DAHANCA[J]. Head Neck,2003,25:711-716
[27]Markou KD, Vlachtsis KC, Nikolaou AC, et al. Incidence and predisposing factors of pharyngocutaneous fistula formation after total laryngectomy. Is there a relationship with tumor recurrence[J]? Eur Arch Otorhinolaryngol,2004,261:61-67
[28]Pinar E, Oncel S, Calli C, Guclu E, Tatar B. Pharyngo-cutaneous fistula after total laryngectomy:emphasis on lymph node metastases as a new predisposing factor [J]. J Otolaryngol Head Neck Surg,2008,37:312-318
[29]Moy RL, Waldman B, Hein DW. A review of sutures and suturing techniques[J]. J Dermatol Surg Oncol,1992,18:785-95
[30]Olutoye OO, Zhu X, Cass DL, et al. Neutrophil recruitment by fetal porcine endothelial cells:implications in scarless fetal wound healing[J]. Pediatr Res,2005,58:1290-1294
[31]戴朴,杨仕明,等.喉切除术后咽瘘的预防和治疗[J].中国耳鼻咽喉头颈外科杂志,2004,11(4)：205～206
[32]吴建烽,吴正虎.预防喉及下咽癌术后咽瘘发生的经验[J].浙江中医药大学学 报,2008,32(6)：754-755
[33]苏志文,宋新汉.喉癌术后咽瘘原因分析及预防[J].实用医学杂志,1995,11(6)：357-358
[34]韦正波,谢莹,等.喉全切除术后咽瘘影响因素的Meta分析[J].中国耳鼻咽喉头颈外科,2007,14(10)：563-566
[35]Goncalves A J, de Souza JA Jr, Menezes M B, et al. Pharyngocutaneous fistulae following total laryngectomy comparison between manual and mechanical sutures [J]. Eur Arch Otorhinolaryngol,2009,266 (11):1973-1978
[36]Lukyanchenko AG. Suturing of a laryngeal defect in laryngectomy [J]. Vestn Otorinolaringol,1971,33:29-30
[37]Antonio Jose Goncalves, J.A.L.de Souza Jr, M.B.Menezes, et al. Pharyngocutaneous fistulae following total laryngectomy comparison between manual and mechanical sutures[J]. Eur Arch Otorhinolaryngol,2009,266:1793-1798
[38]Montoya FS, Galarreta JCR, Del Rey AS, et al. Comparative study between the use of manual versus mechanical sutures in the closing of the mucous defect following a total laryngectomy[J]. Acta Otorrinolaringol Esp,2002,53:343-350
[39]Weiss LS, Miller RH, Bates ML, et al. An animal model for pharyngocutaneous fistulas[J]. Otolaryngol Head Neck Surg,1993,108:738-742
[40]Qureshi S S, Chaturvedi P, Pai P S, et al. A prospective study of phryngocutaneous fistulas follow ing total laryngectomy[J]. J Cancer Res Ther,2005,3:51-56
[41]Patel UA, Keni SP. Pectoralis myofascial flap during salvage laryngectomy prevents pharyngocutaneous fistula[J]. Otolaryngol Head Neck Surg,2009,141 (2):190-195
[42]路学美,张素华.颈阔肌肌筋膜瓣行喉重建的疗效观察[J].现代诊断与治疗,1997,8(5)：275-277
[43]谢允平,冉骞,阙镇如.双蒂颈前带状肌肌瓣在喉癌术后喉功能重建中的应用[J].实用医学杂志,2007,23(16)：2569-2570
[44]Hin-Lun Liu, Jimmy Yu-Wai Chan, William Ignace Wei. The changing role of pectoralis major flap in head and neck reconstruction[J]. Eur Arch Otorhinolaryngol,2010,267: 1759-1763
[45]Young-Hoon Joo, Dong-Il Sun, Jun-Ook Park, et al. Factors predicting fistula following radial forearm free flap reconstruction for head and neck cancer [J]. Oral Oncology, 2010,46:684-687
[46]陈志俊,孙彦,华辉.会厌瓣和胸骨舌骨肌肌筋膜瓣在喉癌喉部分切除喉功能重建中的应用[J].临床耳鼻咽喉科杂志,2005,19(15)：692-694
[47]de Bree R, Reith R, Quak JJ, et al. Free radial forearm flap versus pectoralis major myocutaneous flap reconstruction of oral and oropharyngeal defects:a cost analysis[J]. Clin Otolaryngol,2007,32:275-282
[48]季文樾,惠莲,潘子民,等.喉全切除术后咽瘘的预防[J].临床耳鼻喉科杂志,1999,13(9)：422
[49]谢正福,刘唐威,施焕中.内科重症监护学[M].北京：科学出版社,2006：98
[50]杨春华,孙玉霞,陆平静,等.喉癌术后病人的营养支持[J].中华护理杂志,2001,36(1)：16-18
[51]McCarter MD, Gomez ME, Daly JM. Ealy Postoperative enteral feeding following major upper gastrointestinal surgery [J]. Gastrointest Surg,1997,1:278-285
[52]冯威.喉癌术后患者留置胃管鼻饲与食道反流的探讨[A].中华护理学会2009全国五官科护理学术交流暨专题讲座会议论文汇编[C],2009,78-79
[53]Seikaly H, Park P. Gastroesophageal reflux prophylaxis decreases the incidence of pharyngocutaneous fistula after total laryngectomy[J]. Laryngoscope,1995,105:1220-1222
[54]Seven h, Calis AB, Turgut S. A randomized controlled trial of early oral feeding on laryngectomized patients[J]. Laryngoscope,2003,113:1076-1079
[55]Rodriguez-Cuevas S, Labastida S, Gutierrez F, et al. Oral feeding after total laryngectomy for endolaryngeal cancer[J]. Eur Arch Otorhinolaryngol,1995,252:130-132
[56]Medina JE, Khafif A. Early oral feeding following total laryngectomy[J]. Laryngoscope 2001,111:368-372
[57]Saydam L, Kalcioglu T, Kizilay A. Early oral feeding following total laryngectomy[J]. Am J Otolaryngol,2002,23:277-281
[58]Galli J, De Corso E, Volante M, et al. Postlaryngectomy pharyngocutaneous fistula: incidence, predisposing factors, and therapy[J]. Otolaryngology-Head and Neck Surgery, 2005,133:689-694
[59]Tomkinson A, Shone GR, Dingle A. Pharyngocutaneous fistula following total laryngectomy and postoperative vomiting[J]. Clin Otolaryngol,1996,21:369-370
[60]Redaelli de Zinis LO, Ferrari L, Tomenzoli D, et al. Postlaryngectomy pharyngocutaneous fistula:incidence, predisposing factors, and therapy[J]. Head Neck,1999,21:131-138
[61]Virtaniemi JA, Kumpulainen EJ, Hirvikoski PP, et al. The incidence and etiology of postlaryngectomy pharyngocutaneous fistulae[J]. Head Neck,2001,23:29-33
[62]朱燕英,何金爱.运用湿性敷料配合封闭负压疗法治愈咽瘘患者一例[J].护士进修杂志,2010,25(11)：1021-1022
[63]祝小林,文卫平,蒋爱云.保守治疗咽瘘的临床转归研究[J].临床耳鼻咽喉头颈外科杂志,2008,22(23)：1079-1082
[64]Montgomery WW. Plastic esophageal tube[J]. Ann Otol Rhinol Laryngol,1955,64: 418-421
[65]Angela Lorken.MD, J.Krampert.MD, R.J.Kau,MD. Experiences with the Montgomery Salivary Bypass Tube (MSBT)[J]. Dysphagia,1997,12:79-83
[66]Berry SM, Fischer JE. Classification and pathophysiology of enterocutaneous fistulas [J]. Surg Clin North Am,1996,76:1009-1018
[67]Qureshi S S, Chaturvedi P, Pai P S, et al. A prospective study of phryngocutaneous fistulas follow ing total laryngectomy[J]. J Cancer Res Ther,2005,3:51-56