结合穴位电刺激的机器人辅助上肢康复方法和设备的研究
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摘要
刺激疗法在康复治疗中虽不占主要地位,但却扮演着重要的角色,而穴位刺激则是中国传统医术中常用的刺激疗法之一,研究中医刺激疗法与其它疗法相结合,探究更高效率和临床康复效果的综合康复疗法具有非常重要的理论意义和临床价值。现有康复机器人的研究已经达到了一定的水平,但还不能满足临床综合训练的需要,为此本研究改良了现有的康复机器人平台,使机器人辅助中西医结合训练方式得以实现。具体工作如下:
     1.通过对现有机器人辅助康复疗法和刺激疗法的调研,结合中医理论,提出在机器人辅助上肢自主循迹训练中加入经皮穴位电刺激(TEAS),以实现结合中医刺激疗法的机器人康复训练方式,并为此对现有机器人平台进行改良,令机器人可以通过控制模块,根据训练时的动作阶段施予变换式穴位刺激。
     2.对1名健康男性进行了有关刺激方式的实验,对同一实验对象进行了扎实针、电针灸和经皮穴位电刺激下的机器人辅助循迹运动,以验证不同刺激方式之间的区别。结果显示,电针灸与扎实针对表面肌电信号(sEMG)的影响存在明显区别,而电针灸与经皮穴位电刺激对sEMG的影响则在大部分肌肉上没有明显区别,说明经皮穴位电刺激可以取代电针灸。此结果为经皮穴位刺激结合机器辅助康复训练的实现提供了依据。
     3.进行了正常人的实验,对4名健康男性进行了结合TEAS的循迹运动训练,实验过程中采集sEMG,并以希尔伯特—黄变换(HHT)方法得到平均频率(MNF)以进行评定。结果显示经皮穴位电刺激对机器人辅助下的循迹训练存在一定的影响。随后在健康人实验的基础上进行了患者实验,对8例脑卒中后Brunnstrom 3~5期的偏瘫患者进行结合变换式TEAS的循迹运动训练,结果显示,根据动作阶段切换刺激穴位的刺激方式对较多肌肉的sEMG有影响,其中,由于对肱三头肌的刺激增加了,因此对痉挛性偏瘫患者采用变换式穴位电刺激可能比采用持续刺激更适合。
Stimulation treatment plays an important role, even though it isn’t the principal component of post-stroke hemiplegic rehabilitation. Acupuncture is a familiar stimulation method in Traditional Chinese Medical (TCM). Stimulation of TCM combined with other therapies may provide more efficient and clinical effects for rehabilitation. Therefore, developing of comprehensive therapy has very important theoretical and clinical value. Current research of rehabilitation robot has reached certain levels of achievement, but still can’t meet the needs of comprehensive therapy. To realize combination therapy of TCM and modern rehabilitation, the existing rehabilitation robot had been improved. The main works in this study include:
     1. Combining transcutaneous electrical acupuncture stimulation (TEAS) with upper limb voluntary trajectory tracking tasks (TTT) during robot-assisted rehabilitation training. Embedding TEAS equipment in rehabilitation robot workstation, stimulation model can be determined by motion stage of limb. Altering TEAS control by robot system had been realized.
     2. To verify the different between acupuncture, electro-acupuncture and TEAS, clinical trials had been conducted. One healthy male human received robot-assisted TTT and TENS simultaneously. During the experiment, surface electromyography (sEMG) had been collecting and evaluated. The results indicated that acupuncture and electro-acupuncture carry different influence on sEMG, yet no significant different had found between electro-acupuncture and TEAS. According to the result, transcutaneous electrical stimulation can replace the electro-acupuncture.
     3. To investigate the influence of sustaining TEAS during robot-assisted TTT, four healthy male human who enlisted as volunteer for trials received robot-assisted TTT combined with sustaining TENS. The sEMG of upper limb muscle were recorded and the mean frequency (MNF) of sEMG which calculated by Hilbert-Huang Transform (HHT) were evaluated. The results indicated that sustaining TEAS provide influence on sEMG during robot-assisted TTT. Based on the healthy subjects experiment, clinical trial had been conducted. 8 post-stroke hemiplegic patients (Brunnstrom 3~5) were recruited to received robot-assisted TTT combined with altering TENS. The results illustrate that altering TEAS determined by motion stage of limb can excite more muscle than sustaining TEAS. Because of increasing excitative effect on triceps, it may suitable for cure of spastic Hemiplegia.
引文
[1] Margaret Johnstone. Home Care for the Stroke Patient: Living in a pattern (Third Edition)[M]. New York: Churchill Livingstone. 1996.
    [2] Donnan GA, Fisher M, Macleod M, Davis SM. Stroke[J]. Lancet. 2008, 371 (9624): 1612–1623.
    [3] Strong K, Mathers C, Bonita R. Preventing stroke: saving lives around the world[J]. Lancet Neurology. 2007, 6(2): 182–87.
    [4] Eric Lewin Altschuler, Sidney B Wisdom, Lance Stone, Chris Foster, Douglas Galasko, D Mark E Llewellyn, VS Ramachandran. Rehabilitation of hemiparesis after stroke with a mirror[J]. The Lancet. 1999, 353(9169): 2035-2036.
    [5]朱镛连.神经康复学[M].北京:人民军医出版社. 2001.
    [6] Bruce H Dobkin. Strategies for stroke rehabilitation[J]. Lancet Neurology. 2004, 3(9): 528-536.
    [7]于兑生,恽晓平.运动疗法与作业疗法[M].北京:华夏出版社. 2002.
    [8] Lum P S, Reinkensmeyer D J. Robotic assist devices for bimanual physical therapy: Preliminary experiments[J]. IEEE Transactions on Rehabilitation Engineering. 1993, 1(3): 185-191.
    [9] Lum P S, Lehman S L. The bimanual lifting rehabilitation: an adaptive machine for therapy of stroke patients [J]. IEEE Transactions on Rehabilitation Engineering. 1995, 3(2): 166-174.
    [10] Hogan N, Krebs H I, Charnnarong J, Srikrishna P, Sharon A. MIT-MANUS: A Workstation for Manual and TrainingⅠ. IEEE International Workshop on Robot and Human Communication. 1992, 161-165.
    [11] Krebs H I, Hogan N, Aisen M L, Volpe B T. Robot-aided neurorehabilitation. IEEE Transactions on Rehabilitation Engineering, 1998, 6(1): 75-87.
    [12] Reinkensmeyer D J, Dewald J P A, Rymer W Z. Guidance-based quantification of arm impairment following brain injury[J]: A Pilot Study. IEEE transaction on rehabilitation engineering. 1999, 7(1): 1-11.
    [13] Kahn L E, Zygman M L, Rymer W Z, Reinkensmeyer D J. Effect of robot-assisted and unassisted exercise on functional reaching in chronic hemiparesis[C]. Proceedings 23rd Annual IEEE Engineering in Medicine and Biology Conference, Istanbul, Turkey. 2001.
    [14]胡宇川,季林红.一种偏瘫上肢复合运动的康复训练机器人[J].机械设计与制造, 2004(6): 47-49.
    [15]胡宇川.偏瘫上肢复合运动康复训练机器人的研制[D].北京:清华大学. 2004.
    [16] ZHANG Xiufeng, JI Linhong, GUO Liyun. A novel robot neurorehabilitation for upper limb motion[C]. In: Proceedings of the 27th International Conference of the IEEE Engineering in Medicine and Biology Society, Shanghai International Convention Center, Shanghai. 2005: 5040-5043.
    [17]陈里宁.实现多位姿训练的上肢康复机器人平台的研制[D].北京:清华大学. 2008.
    [18]王子羲,陈里宁,姚重阳,谢群,季林红.上肢机器人辅助康复治疗中变换作业面对复合运动训练的影响[J].中国康复医学杂志. 2009, 24(1): 65-67.
    [19] C. Burgar, P. Lum, P. Shor, H. Vander Loos. Development of robots for rehabilitation therapy: The Palo Alto VA/Stanford experience. J. Rehab. Res. Development. 2000(37), 663-673.
    [20] J. L. Patton, G. Dawe, C. Scharver, F. A. Mussa-Ivaldi, R. Kenyon. Robotics and Virtual Reality: The Development of a Life-Sized 3-D System for the Rehabilitation of Motor Function[C]. In: Proceedings of the 26th Annual International Conference of the IEEE EMBS. 2004(7): 4840-4843.
    [21] Patton JL, Dawe G, Scharver C, Muss-Ivaldi FA, Kenyon R. Robotics and virtual reality: A perfect marriage for motor control research and rehabilitation[J]. Assistive Technology. 2006, 18(2): 181-195.
    [22] Tobias Nef, Robert Riener. ARMin-Design of a novel arm rehabilitation robot. ICORR 2005, 9th international conference on, 2005, 57-60.
    [23] Tobias Nef, Matjaz Mihelj, Gabriela Kiefer, et al. ARMin-exoskeleton for arm therapy in stroke patients, ICORR 2007 10th International Conference on , 2007, 68-74.
    [24] Song R, Tong KY, Hu XL Li L: "Assistive control system using continuous myoelectric signal in robot-aided arm training for patients after stroke", IEEE Transactions on Neural Systems and Rehabilitation Engineering. Volume 16, Issue 4, Aug. 2008 Page(s):371 - 379
    [25] Tong RKY, Intention-driven rehabilitation robotic system (2008), The Journal of the Hong Kong Institution of Engineers, May 2008, pp20
    [26] Hu XL, Tong KY, Song R, Tsang VS, Leung PO and Li L: "Variation of muscle coactivation patterns in chronic stroke during robot-assisted elbow training". Archives of Physical Medicine and Rehabilitation. 2007, 88: 1022-29, August 2007.
    [27] C.T. Freeman, A.M. Hughes, J.H. Burridge, et al. A robotic workstation for stroke rehabilitation of the upper extremity using FES[J]. Medical Engineering & Physics. 2009, 31(3): 364—373.
    [28] Freeman C.T., Hughes A.M., Burridge J.H., et al. An experimental facility using functional electrical stimulation for stroke rehabilitation of the upper limb[C]. In: Proceedings of 10th IEEE International Conference on Rehabilitation Robotics. 2007: 393—400.
    [29] C.T. Freeman, A.M. Hughes, J.H. Burridge, et al. Iterative learning control of FES applied to the upper extremity for rehabilitation[J]. Control Engineering Practice. 2009, 17(3): 368—381.
    [30] Freeman C.T., Hughes A.M., Burridge J.H., et al. A model of the upper extremity using FES for stroke rehabilitation[J]. Journal of Biomechanical Engineering. 2009, 131(3): 031011.
    [31] A.M. Hughes, C.T. Freeman, J.H. Burridge, et al. Shoulder and elbow muscle activity during fully supported trajectory tracking in neurologically intact older people[J]. Journal of Electromyography and Kinesiology. 2009, 13(6): 1025—1034.
    [32] Ann-Marie Hughes,Jane Burridge, Chris Freeman, Paul Chappell, Paul Lewin, Eric Rogers. Robotic trajectory tracking for neurological rehabilitation[J]. Progress in Neurology and Psychiatry. 2008, 12(3): 22-24.
    [33]张建福,闫长栋.人体生理学[M].北京:高等教育出版社,2007.
    [34]王茂斌.康复医学[M].北京:人民卫生出版社. 2009.
    [35] Van Dijk H, Jannink M, Hermens H. Effect of augmented feedback on motor function of the affected upper extremity in rehabilitation patients: a systematic review of randomized controlled trials. J Rehabil Med 2005;37:202–11.
    [36] S. Hesse, M.T. Jahnke, D. Luecke, K.H. Mauritz. Short-term electrical stimulation enhances the effectiveness of Botulinurn toxin in the treatment of lower limb spasticity in hemiparetic patients[J]. Neuroscience Letters. 1995, 201(1):37-40.
    [37] Tihanyi TK, Horvath M, Fazekas G, Hortobagyi T, Tihanyi J. One session of whole body vibration increases voluntary muscle strength transiently in patients with stroke[J]. Clinical Rehabilitation. 2007, 21(9): 782-793.
    [38] Noma Tomokazu, Matsumoto Shuji, Etoh Seiji, Shimodozono Megumi, Kawahira Kazumi. Antispastic effects of the direct application of vibratory stimuli to the spastic muscles of hemiplegic limbs in post-stroke patients[J]. Brain Injury. 2009, 23 (7-8): 623-631.
    [39] Kawahira K, Higashihara K, Matsumoto S, Shimodozono M, Etoh S, Tanaka N, Sueyoshi Y. New functional vibratory stimulation device for extremities in patients with stroke[J]. International Journal of Rehabilitation Research. 2004, 27(4): 335-337.
    [40] Macgregor R, Campbell R, Gladden MH, Tennant N, Young D. Effects of massage on the mechanical behaviour of muscles in adolescents with spastic diplegia: a pilot study[J]. Developmental Medicine & Child Neurology. 2007, 49(3): 187-191.
    [41] Melzack R, Wall PD. Pain Mechanisms: A New Theory[J]. Science. 1965, 150(3699): 971-979.
    [42] Mindy F. Levin, Christina W.Y. Hui-Chan. Relief of hemiparetic spasticity by TENS is associated with improvement in reflex and voluntary motor functions[J]. Electroencephalography and Clinical Neurophysiology. 1992, 85(2):131-142.
    [43] Burridge JH, Ladouceur M. Clinical and therapeutic applications of neuromuscular stimulation: A review of current use and speculation into future developments[J]. Neuromodulation. 2001, 4(4):147—54.
    [44] Bakhtiary AH, Fatemy E. Does electrical stimulation reduce spasticity after stroke? A randomized controlled study[J]. Clinical Rehabilitation. 2008, 22(5):418—425.
    [45] Johansson BB, Haker E, von Arbin M, et al. Acupuncture and transcutaneous nerve stimulation in stroke rehabilitation: a randomized, controlled trial[J].Stroke, 2001, 32(3):707—713.
    [46] Barr JO, Nielsen DH, Soderberg GL. Transcutaneous Electrical Nerve Stimulation Characteristics for Altering Pain Perception[J]. Physical Therapy. 1986, 66(10): 1515—1521.
    [47] Barr JO, Nielsen DH, Soderberg GL. Transcutaneous electrical nerve stimulation characteristics for altering pain perception[J].Physical Therapy, 1986, 66(10):1515—1521.
    [48] Chae J, Bethoux F, Bohine T, et al. Neuromuscular stimulation for upper extremity motor and functional recovery in acute hemiplegia[J].Stroke, 1998, 29(5):975—979.
    [49]林成杰,梁娟.脑卒中痉挛状态的康复治疗[J]. 2009, 24(2): 179-182.
    [50]冯龑,何祥.电刺激与神经康复[J].中国临床康复. 2004, 8(31): 6977-6979.
    [51]李佩芳.针刺拮抗肌群治疗脑卒中后肌张力增高[J].中国康复. 2001, 16(1): 42-43.
    [52]施娟娟.传统针灸结合现代康复理论治疗早期中风偏瘫刍议针刺[J].中外健康文摘. 2008(5): 15-16.
    [53]金肖青,林馨.针刺结合康复训练治疗中风偏瘫临床观察[J].浙江中医药大学学报. 2006, 30(6): .643-644.
    [54]李忠仁.实验针灸学[M].北京:中国中医药出版社. 2007.
    [55]于潇,海英.脑卒中偏瘫痉挛状态的针刺选穴原则[J].中国康复. 2007, 22(4): 274-275.
    [56]黄龙祥.经络学说的理论结构与科学内涵[J].中医杂志. 2002, 43(10): 746-748.
    [57]张雯,杨蓉,吴卫青,陈文华.从经络研究谈中西医结合康复的发展[J]. 2005, 20(4): 240-241.
    [58]石学敏.脑卒中与醒脑开窍[M].北京:科学出版社. 2007.
    [59] Rushton DN. Functional electrical stimulation and rehabilitation—an hypothesis[J].Medical Engineering and Physics, 2003, 25(1):75—78.
    [60] Rushton DN. Functional electrical stimulation[J].Physiological Measurement, 1997, 18(4):241—275.
    [61] Shamay S.M. Ng, Christina W.Y. Hui-Chan. Transcutaneous electrical nerve stimulation combined with task-related training improves lower limb functions in subjects with chronic stroke[J]. Stroke. 2007, 38(11): 2953-2959.
    [62] Mukul Mukherjee, Lisa K. McPeak, John B. Redford, Chao Sun, Wen Liu. The Effect of Electro-Acupuncture on Spasticity of the Wrist Joint in Chronic Stroke Survivors[J]. Archives of physical medicine and rehabilitation. 2007, 88(2): 159-166.
    [63] Wen Liu, Mukul Mukherjee, Chao Sun, Hongzeng Liu, Lisa K. McPeak. Electroacupuncture may help motor recovery in chronic stroke survivors: A pilot study[J]. Journal of Rehabilitation Research & Development. 2008, 45(4): 587-595.
    [64] Joseph A. Balogun1, Silvio Biasci, Lu Han. The effects of acupuncture, electroneedling and transcutaneous electrical stimulation therapies on peripheral haemodynamic functioning[J]. Disability & Rehabilitation. 1998, 20(2):41-48.
    [65] George A. Ulett, Songping Han, Ji-sheng Han. Electroacupuncture: Mechanisms and Clinical Application[J]. Biological Psychiatry. 1998, 44(2): 129—138.
    [66] N.E.Huang, Z. Shen, S.R. Long, et al. The empirical mode decomposition and the Hilbert spectrum for non-linear and non stationary time series analysis[C].In Proceedings of the Royal Society of London, 1998, 454:903—995. London, England.
    [67] G. Rilling, P. Flandrin,P. Goncalves. On Empirical Mode Decomposition and its algorithms[C]. IEEE-EURASIP Workshop on Nonlinear Signal and Image Processing NSIP-03. 2003, Grado, Italy.
    [68] Joseph A. Balogun1, Silvio Biasci, Lu Han. The effects of acupuncture, electroneedling and transcutaneous electrical stimulation therapies on peripheral haemodynamic functioning[J]. Disability & Rehabilitation. 1998, 20(2):41-48.
    [69] Kuhn A, Keller T, Micera S, Morari M. Array electrode design for transcutaneous electrical stimulation: a simulation study[J]. Medical Engineering and Physics. 2009, 31(8): 945—951.
    [70] Kuhn A, Keller T, Lawrence M, et al. The Influence of Electrode Size on Selectivity and Comfort in Transcutaneous Electrical Stimulation of the Forearm[J]. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2010.
    [71]王芗斌,何坚,李天骄,陶静,杨珊莉,陈立典.不同频率电针治疗脑卒中下肢痉挛患者最大等长收缩的表面肌电图研究[J].福建中医学院学报. 2008, 18(6): 40-42.
    [72]何坚.不同频率电针治疗脑卒中下肢痉挛的表面肌电研究[D].广州:广州中医药大学. 2008.
    [73] de Kroon JR, Ijzerman MJ, Chae J, Lankhorst GJ, Zilvold G. Relation between stimulation characteristics and clinical outcome in studies using electrical stimulation to improve motorcontrol of the upper extremity in stroke[J]. Journal of rehabilitation medicine. 2005, 37(2): 65-74.
    [74]李忠仁.实验针灸学[M].北京:中国中医药出版社. 2007.
    [75]张鹰,吴祥林,秦晓江,冯尚武.以现代康复理念探讨传统针刺治疗脑卒中[J].中国康复. 2004, 19(6): 371-372.
    [76]章薇.张力平衡针法在中风偏瘫康复中的应用[J].中国临床医生. 2004, 32(6):38-40.
    [77]刘智,章薇,娄必丹,林华,李金香,王净净.张力平衡针法对脑卒中痉挛瘫痪患者ADL和生存质量的影响[J]. 2009, 24(6): 370-371.
    [78]熊家轩,陈奕雄,吴思平.针刺拮抗肌群对中风后痉挛性偏瘫的临床研究.当代医学. 2009, 15(19): 151-152.
    [79] Alvaro Pascual-Leone, Amir Amedi, Felipe Fregni, , et al. The Plastic Human Brain Cortex[J]. Annual Review of Neuroscience. 2005, 28:377-401.
    [80]陈之罡.巨刺运动疗法对偏瘫患者患侧上肢痉挛的影响[J].中国针灸康复理论与实践,2004 ,10 (12): 744-744.
    [81]肖献忠.病理生理学[M].北京:高等教育出版社. 2004.
    [82]姜桂美,吴思平,贾超,刘映芬.不同刺激量针刺拮抗肌与主动肌治疗脑卒中后痉挛性偏瘫的临床疗效观察[J].针灸临床杂志. 2008, 24(11):1-3.
    [83] Xie H, Wang Z. Mean frequency derived via Hilbert-Huang transform with application to fatigue EMG signal analysis[J].Computer Methods and Programs in Biomedicine, 2006, 82(2):114—120.
    [84]谢洪波.基于非线性与时频分析理论的表面肌电信号特征信息提取与分类研究[D].上海:上海交通大学.2006.
    [85] Cifrek M, Medved V, Tonkovi? S, et al. Surface EMG based muscle fatigue evaluation in biomechanics[J].Clinical Biomechanics, 2009, 24(4):327—340.
    [86]王国祥,岳春林.随意运动与电刺激诱发胫骨前肌疲劳过程中肌电图的变化特征[J].体育学刊,2007,14(1):56—59.
    [87] Roberto Casale, Haim Ring, Alberto Rainoldi. High frequency vibration conditioning stimulation centrally reduces myoelectrical manifestation of fatigue in healthy subjects[J]. Journal of Electromyography and Kinesiology. 2009, 19(5): 998-1004.
    [88] Mario Cifrek, Stanko Tonkovi, Vladimir Medved. Measurement and analysis of surface myoelectric signals during fatigued cyclic dynamic contractions[J]. Measurement. 2000, 27(2): 85—92.
    [89]郭立云.神经康复机器人辅助训练轨迹的评价与规划方法研究[D].北京:清华大学.2006.
    [90]金荣疆,朱天民,罗荣,郑重,杨红,冯媛.电针对实验性脑梗死大鼠脑干、脊髓组织GABAB受体影响的研究[J].中国老年学杂志. 28(16): 1573-1575.

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