网膜素-1与冠状动脉粥样硬化性心脏病的相关性研究
摘要
目的:通过测定血清网膜素1(omentin-1)及超敏C反应白蛋白(high sensitive C-reactive protein,hs-CRP)水平,分析omentin-1与血脂的关系,进一步探讨omentin-1与冠心病的关系,为冠心病发病机制提供理论依据。
方法:入选病例组80例及对照组52例,研究对象来自2010年12月至2011年5月就诊于山西省心血管病医院心内科住院患者。冠心病组[男性56例,女性24例,平均年龄(58.43±13.34)岁)]：冠心病诊断标准符合1979年WHO关于冠心病诊断标准,并经冠脉造影证实：左前降支、回旋支,右冠状动脉至少有一支血管管腔直径狭窄约≥50%；对照组[男性32例,女性20例,平均年龄(56.78±12.89)岁]：为同期住院冠脉造影阴性,且排除冠心病诊断。采用酶联免疫吸附试验(ELISA)测定血清网膜素-1和超敏C-反应蛋白水平。采用SPSS13.0软件包分析,以P<0.05有统计学意义。
结果:1.病例组中血清网膜素-1水平明显低于对照组,差异有统计学意义(t=3.670,p=0.0090)。2、在病例组中血清网膜素-1水平与胆固醇(CHO)(r=-0.579,p<0.05)、低密度脂蛋白-胆固醇(LDL-C)(r=-0.520,p<0.05)、甘油三酯(TG)(r=-0.564,p<0.05)、载脂蛋白B(apoB)(r=-0.470, p<0.05)呈负相关；与高密度脂蛋白-胆固醇(HDL-C)(r=0.693,p<0.05)、载脂蛋白AI(apoAI)(r=0.501, p<0.05)呈正相关；与hs-CRP之间无相关性(r=0.271,P=0.309)。
结论:血清网膜素-1可能与冠心病的发生有相关性,血清网膜素-1水平可能成为评价冠心病危险度的良好指标,有待大样本病例对照实验和前瞻性实验来加以证实。
Objective:To analysis relationship of the omentin-1and serum lipids and further explore the relationship between omentin-1and coronary heart disease through determination of level of serum omentin-1and high sensitive C-reactive protein (hs-CRP), to provide the oretical basis for pathogenesis of coronary heart disease.
Methods:There were80cases of patients group and52cases of control group from inpatients of cardiovascular hospital of shanxi province in December2010to May2011. Diagnosis of patients with coronary artery disease in patients group consistent with diagnosis standard of WHO on coronary heart disease in1979, and confirmed by coronary angiography:lumen diameter stenosis of at least one vascular of the left anterior descending artery, circumflex and right coronary artery was about more than50%. Among the patients group,56were male,24were female, meanage (58.43±13.34) years old. The control group, patients hospitalized in the same period and coronary angiography negative, and had been exclused of coronary artery disease, among them,32were male,20were female, mean age (56.78±12.89). Using enzyme-linked immunosorbent assay (ELISA) for determination of serum omentin-1and high sensitivity C-reactive protein level. Analysis and compared measurement data with methods of mean±standard deviation, t test, Pearson correlation analysis et al; using SPSS13.0software package to analysis, with statistical significance when P<0.05.
Results:Serum omentin-1level of cases from patients group was significantly lower than the control group, the difference was statistically significant (t=3.670, P=0.0090). In patients group, serum omentin-1levels was negatively correlated with cholesterol (CHO)(r=-0.579, P<0.05), low density lipoprotein cholesterol (LDL-C)(r=-0.520, P<0.05), triglyceride (TG)(r=-0.564, P<0.05), load lipoprotein B(apoB)(r=-0.470,P<0.05); and positively correlated with high density lipoprotein cholesterol (HDL-C)(r=0.693,P<0.05), apolipoprotein AI (apoAI)(r=0.501,P<0.05), and had no correlation with hs-CRP(r=0.271,P=0.309).
Conclusion:the serum omentin-1may be associated with the occurrence of coronary heart disease, serum omentin-1level may be a good indicator of the evaluation of coronary artery disease risk.We need to confirm it with more large sample cases of control experiments and prospective experiments
方法:入选病例组80例及对照组52例,研究对象来自2010年12月至2011年5月就诊于山西省心血管病医院心内科住院患者。冠心病组[男性56例,女性24例,平均年龄(58.43±13.34)岁)]：冠心病诊断标准符合1979年WHO关于冠心病诊断标准,并经冠脉造影证实：左前降支、回旋支,右冠状动脉至少有一支血管管腔直径狭窄约≥50%；对照组[男性32例,女性20例,平均年龄(56.78±12.89)岁]：为同期住院冠脉造影阴性,且排除冠心病诊断。采用酶联免疫吸附试验(ELISA)测定血清网膜素-1和超敏C-反应蛋白水平。采用SPSS13.0软件包分析,以P<0.05有统计学意义。
结果:1.病例组中血清网膜素-1水平明显低于对照组,差异有统计学意义(t=3.670,p=0.0090)。2、在病例组中血清网膜素-1水平与胆固醇(CHO)(r=-0.579,p<0.05)、低密度脂蛋白-胆固醇(LDL-C)(r=-0.520,p<0.05)、甘油三酯(TG)(r=-0.564,p<0.05)、载脂蛋白B(apoB)(r=-0.470, p<0.05)呈负相关；与高密度脂蛋白-胆固醇(HDL-C)(r=0.693,p<0.05)、载脂蛋白AI(apoAI)(r=0.501, p<0.05)呈正相关；与hs-CRP之间无相关性(r=0.271,P=0.309)。
结论:血清网膜素-1可能与冠心病的发生有相关性,血清网膜素-1水平可能成为评价冠心病危险度的良好指标,有待大样本病例对照实验和前瞻性实验来加以证实。
Objective:To analysis relationship of the omentin-1and serum lipids and further explore the relationship between omentin-1and coronary heart disease through determination of level of serum omentin-1and high sensitive C-reactive protein (hs-CRP), to provide the oretical basis for pathogenesis of coronary heart disease.
Methods:There were80cases of patients group and52cases of control group from inpatients of cardiovascular hospital of shanxi province in December2010to May2011. Diagnosis of patients with coronary artery disease in patients group consistent with diagnosis standard of WHO on coronary heart disease in1979, and confirmed by coronary angiography:lumen diameter stenosis of at least one vascular of the left anterior descending artery, circumflex and right coronary artery was about more than50%. Among the patients group,56were male,24were female, meanage (58.43±13.34) years old. The control group, patients hospitalized in the same period and coronary angiography negative, and had been exclused of coronary artery disease, among them,32were male,20were female, mean age (56.78±12.89). Using enzyme-linked immunosorbent assay (ELISA) for determination of serum omentin-1and high sensitivity C-reactive protein level. Analysis and compared measurement data with methods of mean±standard deviation, t test, Pearson correlation analysis et al; using SPSS13.0software package to analysis, with statistical significance when P<0.05.
Results:Serum omentin-1level of cases from patients group was significantly lower than the control group, the difference was statistically significant (t=3.670, P=0.0090). In patients group, serum omentin-1levels was negatively correlated with cholesterol (CHO)(r=-0.579, P<0.05), low density lipoprotein cholesterol (LDL-C)(r=-0.520, P<0.05), triglyceride (TG)(r=-0.564, P<0.05), load lipoprotein B(apoB)(r=-0.470,P<0.05); and positively correlated with high density lipoprotein cholesterol (HDL-C)(r=0.693,P<0.05), apolipoprotein AI (apoAI)(r=0.501,P<0.05), and had no correlation with hs-CRP(r=0.271,P=0.309).
Conclusion:the serum omentin-1may be associated with the occurrence of coronary heart disease, serum omentin-1level may be a good indicator of the evaluation of coronary artery disease risk.We need to confirm it with more large sample cases of control experiments and prospective experiments
引文
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[17]Ridker PM Cushman M Stampfer MJ et a1Inflammation aspi tinand the risk of cardiovascular disease in apparently healthy men N Engl J Med199733673-79.
[18]Hofemeister HM Ehler R Buttcher E et a1Coomparisom of CreactiveProtein and terminl complement complex in patients withunstable angina pectorisversus stable angina pectoris Am J Cardiol200289909-912.
[19]Koerig W Inflammation and coronary heart disease an overview Cardiol Rev2001913-35.
[20] C
[A],2007228253-256.
[21] Acharya DKP2C ()2006341502.
[22] C D
[A].,2009,8(13)1032-1035.
[23][S]2006590-591.
[24] C [A].,2009,19(4).
[25]A uer J, Berent R, L assnig E, et al. C-reactive p ro tein and co ronary arterydisease[J]. Jpn Heart J,2002,43(6):07-19.
[26],,, h s-CRP
[A].2003410504-506.
[17]Ridker PM Cushman M Stampfer MJ et a1Inflammation aspi tinand the risk of cardiovascular disease in apparently healthy men N Engl J Med199733673-79.
[18]Hofemeister HM Ehler R Buttcher E et a1Coomparisom of CreactiveProtein and terminl complement complex in patients withunstable angina pectorisversus stable angina pectoris Am J Cardiol200289909-912.
[19]Koerig W Inflammation and coronary heart disease an overview Cardiol Rev2001913-35.
[20] C
[A],2007228253-256.
[21] Acharya DKP2C ()2006341502.
[22] C D
[A].,2009,8(13)1032-1035.
[23][S]2006590-591.
[24] C [A].,2009,19(4).
[25]A uer J, Berent R, L assnig E, et al. C-reactive p ro tein and co ronary arterydisease[J]. Jpn Heart J,2002,43(6):07-19.
[26],,, h s-CRP
[A].2003410504-506.