二藤通痹合剂配合康复体操治疗强直性脊柱炎的疗效观察
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摘要
目的：客观评价二藤通痹合剂配合康复体操治疗强直性脊柱炎的临床疗效。
方法：选择60例符合纳入标准的强直性脊柱炎患者随机分为治疗组与对照组。治疗组：给予二藤通痹合剂配合强直性脊柱炎康复体操,二藤通痹合剂每次20ml,每日3次,口服；康复体操,依照《康复体操图文指导》所示,每天早晚各一次,每次运动时间约15分钟；对照组：给予二藤通痹合剂每次20ml,每日3次,口服。观察治疗4周、8周和12周后的BASDAI、BASFI评分、外周关节肿胀疼痛数、胸廓、脊柱活动度,治疗12周后的CRP、ESR、血常规、肝肾功能等各项观察指标。
结果：治疗组：治疗4周后躯体功能、脊柱痛、脊柱僵硬、病人总体评价、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、脊柱后仰度与治疗前比较均有统计学意义(P<0.05)。枕墙距、脊柱侧屈与治疗前比较无统计学意义(P>0.05)。治疗8周与12周后躯体功能、脊柱痛、脊柱僵硬、病人总体评价、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、枕墙距、脊柱侧屈、脊柱后仰度与治疗前比较均有统计学意义(P<0.05)。对照组：治疗4周后脊柱痛、病人总体评价、外周关节疼痛数数目与治疗前比较均有统计学意义(P<0.05)。躯体功能、脊柱僵硬、胸廓活动度、Schober试验、指地距、枕墙距、脊柱侧屈、脊柱后仰度与治疗前比较无统计学意义(P>0.05)。治疗8周与12周后躯体功能、脊柱痛、脊柱僵硬、病人总体评价、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、脊柱侧屈、脊柱后仰度与治疗前比较均有统计学意义(P<0.05)。枕墙距与治疗前比较无统计学意义(P>0.05)。治疗组与对照组相比：治疗4周后,两组间躯体功能、脊柱僵硬、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、脊柱后仰度比较均有统计学意义(P<0.05),治疗组优于对照组。12周后躯体功能、脊柱痛、脊柱僵硬、病人总体评价、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、枕墙距、脊柱后仰度比较均有统计学意义(P<0.05),治疗组优于对照组。
治疗后12周,治疗组与对照组的CRP及ESR与治疗前比较均有统计学意义(P<0.05),治疗组的CRP与对照组相比有统计学意义(P<0.05),治疗组优于对照组。
结论：二藤通痹合剂配合康复体操治疗强直性脊柱炎疗效确切,且疗效优于二藤通痹合剂。
Objective:
Our study is to summarize the characteristic of TCM determination of treatment based in pathogenesis obtained through differentiation of symptoms and signs and western medicine therapeutics by information of rheumatoid arthritis patients, and know the history regularity further, so can give proof to better treatment.
Methods:
To evaluate the clinical efficacy of Erteng Tongbi Mixture combined with rehabilitation gymnastics on Treating Ankylosing Spondilitis. Method:Choose sixty examples which accorded with standardment of AS, divide them into two groups ranmdomly. Therapy group treated by Erteng Tongbi Mixture combined with rehabilitation gymnastics, take 20ml once, three times a day, combined with rehabilitation gymnastics, which is followed with the《The instructions of rehabilitation gymnastics》,treat for three months;control group treated by Erteng Tongbi Mixture, take 20ml once, three times a day, treat for three months. To observe the clinical symptoms such as BASDAI、BASFI score, PGV score, peripheral index number of arthrosis swell,activity of thoracic skeleton, activity of the spongdy, after four weeks, eight weeks, twelve weeks;to observe the lab result such as the CRP, ESR after twelve weeks treatment, to monitor blood routine, the function of liver and kidney.
Results:
Therapy group:After four weeks treatment,comared to the original level, body function, rachialgia, stiffness of spondy, total self-assessment, peripheral swelling arthrosis,activity of thoracic skeleton, Schober test, distance between fingers and ground, antisernum hypsokinesis were improved significantly(P<0.05);distance between head and wall, side flection of antisternum were not improved significantly(P>0.05). After eight weeks and twelve weeks treatment, compared to the original level, body function, rachialgia, stiffness of spondy, total self-assessment, peripheral swelling arthrosis, activity of thoracic skeleton, Schober test, distance between fingers and ground, distance between head and wall, side flection of antisternum, antisernum hypsokinesis were improved significantly(P<0.05).
Conclusion:
After four weeks treatment, compared to the original level, rachialgia, total self-assessment, peripheral swelling arthrosis were improved significantly(P<0.05).
body function, stiffness of spondy, activity of thoracic skeleton, Schober test, distance between fingers and ground, distance between head and wall, side flection of antisternum, antisernum hypsokinesis were not improved significantly(P>0.05). After eight weeks and twelve weeks treatment, compared to the original level, body function, rachialgia, stiffness of spondy, total self-assessment, peripheral swelling arthrosis, activity of thoracic skeleton, Schober test, distance between fingers and ground, side flection of antisternum, antisernum hypsokiolnesis were improved significantly(P<0.05); distance between head and wall were not improved significantly(P>0.05). Therapy group VS control group:After eight weeks treatment, there was difference in body function, stiffness of spondy, peripheral swelling arthrosis, activity of thoracic skeleton, Schober test, distance between fingers and ground, antisernum hypsokinesis between them(P<0.05). After twelve weeks treatment, there was difference in body function, rachialgia, stiffness of spondy, total self-assessment, peripheral swelling arthrosis, activity of thoracic skeleton, Schober test, distance between fingers and ground, distance between head and wall, antisernum hypsokinesis between them(P<0.05).
After twelve weeks treatment, compared to original level,the CRP and ESR were improved significantly in both groups(P<0.05). The CRP of therapy group was improved significantly than control group(P<0.05).
Conclusion:Erteng Tongbi Mixture combined with rehabilitation gymnastics has the certain therapeutic effect of treating AS. And the therapeutic effect of Erteng Tongbi Mixture combined with rehabilitation gymnastics surpasses the therapeutic effect of Erteng Tongbi Mixture.
方法：选择60例符合纳入标准的强直性脊柱炎患者随机分为治疗组与对照组。治疗组：给予二藤通痹合剂配合强直性脊柱炎康复体操,二藤通痹合剂每次20ml,每日3次,口服；康复体操,依照《康复体操图文指导》所示,每天早晚各一次,每次运动时间约15分钟；对照组：给予二藤通痹合剂每次20ml,每日3次,口服。观察治疗4周、8周和12周后的BASDAI、BASFI评分、外周关节肿胀疼痛数、胸廓、脊柱活动度,治疗12周后的CRP、ESR、血常规、肝肾功能等各项观察指标。
结果：治疗组：治疗4周后躯体功能、脊柱痛、脊柱僵硬、病人总体评价、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、脊柱后仰度与治疗前比较均有统计学意义(P<0.05)。枕墙距、脊柱侧屈与治疗前比较无统计学意义(P>0.05)。治疗8周与12周后躯体功能、脊柱痛、脊柱僵硬、病人总体评价、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、枕墙距、脊柱侧屈、脊柱后仰度与治疗前比较均有统计学意义(P<0.05)。对照组：治疗4周后脊柱痛、病人总体评价、外周关节疼痛数数目与治疗前比较均有统计学意义(P<0.05)。躯体功能、脊柱僵硬、胸廓活动度、Schober试验、指地距、枕墙距、脊柱侧屈、脊柱后仰度与治疗前比较无统计学意义(P>0.05)。治疗8周与12周后躯体功能、脊柱痛、脊柱僵硬、病人总体评价、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、脊柱侧屈、脊柱后仰度与治疗前比较均有统计学意义(P<0.05)。枕墙距与治疗前比较无统计学意义(P>0.05)。治疗组与对照组相比：治疗4周后,两组间躯体功能、脊柱僵硬、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、脊柱后仰度比较均有统计学意义(P<0.05),治疗组优于对照组。12周后躯体功能、脊柱痛、脊柱僵硬、病人总体评价、外周关节疼痛数数目、胸廓活动度、Schober试验、指地距、枕墙距、脊柱后仰度比较均有统计学意义(P<0.05),治疗组优于对照组。
治疗后12周,治疗组与对照组的CRP及ESR与治疗前比较均有统计学意义(P<0.05),治疗组的CRP与对照组相比有统计学意义(P<0.05),治疗组优于对照组。
结论：二藤通痹合剂配合康复体操治疗强直性脊柱炎疗效确切,且疗效优于二藤通痹合剂。
Objective:
Our study is to summarize the characteristic of TCM determination of treatment based in pathogenesis obtained through differentiation of symptoms and signs and western medicine therapeutics by information of rheumatoid arthritis patients, and know the history regularity further, so can give proof to better treatment.
Methods:
To evaluate the clinical efficacy of Erteng Tongbi Mixture combined with rehabilitation gymnastics on Treating Ankylosing Spondilitis. Method:Choose sixty examples which accorded with standardment of AS, divide them into two groups ranmdomly. Therapy group treated by Erteng Tongbi Mixture combined with rehabilitation gymnastics, take 20ml once, three times a day, combined with rehabilitation gymnastics, which is followed with the《The instructions of rehabilitation gymnastics》,treat for three months;control group treated by Erteng Tongbi Mixture, take 20ml once, three times a day, treat for three months. To observe the clinical symptoms such as BASDAI、BASFI score, PGV score, peripheral index number of arthrosis swell,activity of thoracic skeleton, activity of the spongdy, after four weeks, eight weeks, twelve weeks;to observe the lab result such as the CRP, ESR after twelve weeks treatment, to monitor blood routine, the function of liver and kidney.
Results:
Therapy group:After four weeks treatment,comared to the original level, body function, rachialgia, stiffness of spondy, total self-assessment, peripheral swelling arthrosis,activity of thoracic skeleton, Schober test, distance between fingers and ground, antisernum hypsokinesis were improved significantly(P<0.05);distance between head and wall, side flection of antisternum were not improved significantly(P>0.05). After eight weeks and twelve weeks treatment, compared to the original level, body function, rachialgia, stiffness of spondy, total self-assessment, peripheral swelling arthrosis, activity of thoracic skeleton, Schober test, distance between fingers and ground, distance between head and wall, side flection of antisternum, antisernum hypsokinesis were improved significantly(P<0.05).
Conclusion:
After four weeks treatment, compared to the original level, rachialgia, total self-assessment, peripheral swelling arthrosis were improved significantly(P<0.05).
body function, stiffness of spondy, activity of thoracic skeleton, Schober test, distance between fingers and ground, distance between head and wall, side flection of antisternum, antisernum hypsokinesis were not improved significantly(P>0.05). After eight weeks and twelve weeks treatment, compared to the original level, body function, rachialgia, stiffness of spondy, total self-assessment, peripheral swelling arthrosis, activity of thoracic skeleton, Schober test, distance between fingers and ground, side flection of antisternum, antisernum hypsokiolnesis were improved significantly(P<0.05); distance between head and wall were not improved significantly(P>0.05). Therapy group VS control group:After eight weeks treatment, there was difference in body function, stiffness of spondy, peripheral swelling arthrosis, activity of thoracic skeleton, Schober test, distance between fingers and ground, antisernum hypsokinesis between them(P<0.05). After twelve weeks treatment, there was difference in body function, rachialgia, stiffness of spondy, total self-assessment, peripheral swelling arthrosis, activity of thoracic skeleton, Schober test, distance between fingers and ground, distance between head and wall, antisernum hypsokinesis between them(P<0.05).
After twelve weeks treatment, compared to original level,the CRP and ESR were improved significantly in both groups(P<0.05). The CRP of therapy group was improved significantly than control group(P<0.05).
Conclusion:Erteng Tongbi Mixture combined with rehabilitation gymnastics has the certain therapeutic effect of treating AS. And the therapeutic effect of Erteng Tongbi Mixture combined with rehabilitation gymnastics surpasses the therapeutic effect of Erteng Tongbi Mixture.
引文
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