摘要
目的:探讨内源性β—葡萄糖醛酸酶与原发性肝内胆管结石的关系。
方法:采用改良的Fishman方法测定原发性肝内胆管结石患者的胆汁及肝组织中内源性β—葡萄糖醛酸酶的活性。
结果:1.原发性肝内胆管结石患者结石侧胆管胆汁内源性β-G的活性明显高于对照组,而非结石侧胆管胆汁内源性β-G的活性与对照组无显著性差异。2.左肝结石患者的胆汁内源性β-G的活性左侧明显高于右侧,右肝结石患者的胆汁内源性β-G的活性右侧明显高于左侧,而左右肝同时有结石的患者左右侧胆汁内源性β-G的活性差别无显著性。3.左肝结石患者的肝组织内源性β-G的活性左侧明显高于右侧,右肝结石患者的肝组织内源性β-G的活性右侧明显高于左侧,而左右肝同时有结石的患者左右侧肝组织内源性β-G的活性差别无显著性。
结论:象外源性β-G一样,内源性β-G也可能参与原发性肝内胆管结石的成石过程。并且,原发性肝内胆管结石患者内源性β-G肝内分布存在差异,表现为结石侧内源性β-G较非结石侧明显升高,提示原发性肝内结石可能为肝
安徽医科大学硕士学位论文
内局限性病变,这为外科手术切肝治疗肝内胆管结石提供一定的理论基础。
Objective:To investigate the relationship between endogenous -glucuronidase( β-G) and the primary intrahepatic bile duct stone. Methods:The activity of endogenous β-G in bile and hepatic tissue from the paitents with the intrahepatic bile duct stone was measured by modified Fishman method..
Results:1 The activity of endogenous β-G in the bile from bile duct with intrahepatic bile duct stone was significantly higher than that of the control group,while the activity of endogenous β-G without intrahepatic bile duct stone was not significantly higher than that of the control group. 2 The activity of endogenous β-G in the bile of left hepatic duct with left intrahepatic bile duct stone was significantly higher than that of the right hepatic duct in the same patient, while right was significantly higher than that of the left when the patients with right intrahepatic bile duct stone. Meanwhile, it showed unsignificant difference between endogenous β-G activity of the bile from left intrahepatic bile duct and that of right intrahepatic bile duct. 3 The activity of endogenous β-G in the hepatic tissue of left hepatic duct from the patients with left intrahepatic bile duct stone was significantly higher than that of the right, while
the right was significantly higher than that of the left when the patients with right intrahepatic bile duct stone. Meanwhile, it showed unsignificant difference between endogenous β -G activity of the hepatic tissue from left hepatic tissue and that of right hepatic tissue.
Conclusions: Endogenous β-Glucuronidase( β -G) might be play a role in the formation of gallstone just as the exogenous β-Glucuronidase does. The activity of endogenous β -G was diference in different parts of the liver of the patients with intrahepatic bile duct stone.It showed that the activity of endogenous β -G with intrahepatic bile duct stone was significantly higher than that of the control group.It also hints that the formation of primary intrahepatic bile duct stone might be local pathological changes,which provided a rationale for the clinic to heal patients with intrahepatic bile duct stone with cutting part of the pathological liver.
引文
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