培养方式与条件对蛹虫草代谢产物产生的影响研究
|
摘要
蛹虫草是一种具有多种生物学活性的食药用真菌,目前对蛹虫草的研究多集中在固体栽培中子实体产量的提高、液体发酵中虫草素含量的提高以及子实体或者菌丝体浸提液药理方面的研究等领域,而对基础营养物质对蛹虫草子实体生长以及有效成分合成与积累的影响研究很少。
根据蛹虫草正常生长最基础的营养需求:底料、碳源、氮源、矿物元素,通过优化组合筛选出了10种培养基,按照同一培养条件进行人工栽培。实验得出2号培养基和5号培养基有利于提高子实体产量。添加4号氮源的培养基比添加1号氮源的培养基更有利于提高子实体产量。
分析比较了虫草多糖的两种常用检测方法:苯酚-硫酸法和蒽酮-硫酸法。试验发现蒽酮-硫酸法更为精确。进一步对蒽酮-硫酸法做了改进,改进的蒽酮-硫酸法不仅大大减少了实验误差,而且显色物质在4h后仍然稳定。
以蛹虫草子实体为原料,对影响多糖提取的条件进行了研究。以影响多糖产率的四大因素提取温度、提取时间、提取次数、固液比设计正交实验最终确定蛹虫草多糖提取的最佳工艺条件为:40倍水提取两次,每次在100℃下提取2h。
蛹虫草有效成分提取、检测后发现4号培养基最有利于虫草多糖在子实体中积累,多糖产率达到15.25%。3号培养基最有利于甘露醇在子实体中积累,甘露醇产率达到7.00%。1号培养基有利于抗氧化物质的积累,粗提物对邻苯三酚自氧化的抑制率达到62.12%。
综合以上四项分析,10号培养基对提高蛹虫草子实体内外品质最为有利。
Cordyceps militaris (L.) Link. is an edible and medicinal fungus bearing various biological activities. Great efforts have been devoted to improve the output of fruiting bodies by solid culture, to improve the contents of cordycepin in liquid fermention and to explore the medicinal efficacy of extracts from both fruiting bodies and mycelium of Cordyceps militaris, while little attention has been paid to the study of how the basic nutrients influence the fruiting body growth and the synthesis and accumulation of bioactive metabolites of Cordyceps militaris.
Ten culture mediums were prepared according to the basic nutritional requirements of main substrate ingredient, carbon sources, nitrogen sources and mineral elements and tested in the same condition. The results showed that Medium 2 and Medium 5 are propitious to improve the output of fruiting bodies of Cordyceps militaris. The medium adding Nitrogen Source 4 is more beneficial to improve the output of fruiting bodies than that adding Nitrogen Source 1.
Two commonly used methods to detect polysaccharides were compared. The anthrone method was proved to be more accurate than the phenol-sulphuric acid method. The anthrone method has been modified. The color reaction of the modified anthrone method was still stable after four hours; furthermore, the system error was greatly reduced.
The extraction condition of polysaccharides was studied using fruiting bodies of Cordyceps militaris. An orthogonal experiment was employed based on four factors that affect the yield of polysaccharides including the extracting time and temperature, extracting times and the solid to solution ratio. The optimized condition to extract polysaccharides was established as extracted two times with 40 times volume of boiling water, two hours for each extraction.
The active component analysis showed that the production rate of polysaccharides was up to 15.25% in Medium 4, which was the most advantageous for the accumulation of polysaccharides in the fruiting body of Cordyceps militaris. The production rate of mannite was up to 7.00% in Medium 3, which was the best medium for accumulation of mannite in the fruiting body. Medium 1 was the most advantageous for accumulation of antioxidant substances in the fruiting body, the inhibitate rate of Pyrogallol auto-xidant of the liquid extracts from fruiting body was 62.12%.
Combine the above four analyses, the Medium 10 is the best medium to improve the total quality of Cordyceps militaris.
根据蛹虫草正常生长最基础的营养需求:底料、碳源、氮源、矿物元素,通过优化组合筛选出了10种培养基,按照同一培养条件进行人工栽培。实验得出2号培养基和5号培养基有利于提高子实体产量。添加4号氮源的培养基比添加1号氮源的培养基更有利于提高子实体产量。
分析比较了虫草多糖的两种常用检测方法:苯酚-硫酸法和蒽酮-硫酸法。试验发现蒽酮-硫酸法更为精确。进一步对蒽酮-硫酸法做了改进,改进的蒽酮-硫酸法不仅大大减少了实验误差,而且显色物质在4h后仍然稳定。
以蛹虫草子实体为原料,对影响多糖提取的条件进行了研究。以影响多糖产率的四大因素提取温度、提取时间、提取次数、固液比设计正交实验最终确定蛹虫草多糖提取的最佳工艺条件为:40倍水提取两次,每次在100℃下提取2h。
蛹虫草有效成分提取、检测后发现4号培养基最有利于虫草多糖在子实体中积累,多糖产率达到15.25%。3号培养基最有利于甘露醇在子实体中积累,甘露醇产率达到7.00%。1号培养基有利于抗氧化物质的积累,粗提物对邻苯三酚自氧化的抑制率达到62.12%。
综合以上四项分析,10号培养基对提高蛹虫草子实体内外品质最为有利。
Cordyceps militaris (L.) Link. is an edible and medicinal fungus bearing various biological activities. Great efforts have been devoted to improve the output of fruiting bodies by solid culture, to improve the contents of cordycepin in liquid fermention and to explore the medicinal efficacy of extracts from both fruiting bodies and mycelium of Cordyceps militaris, while little attention has been paid to the study of how the basic nutrients influence the fruiting body growth and the synthesis and accumulation of bioactive metabolites of Cordyceps militaris.
Ten culture mediums were prepared according to the basic nutritional requirements of main substrate ingredient, carbon sources, nitrogen sources and mineral elements and tested in the same condition. The results showed that Medium 2 and Medium 5 are propitious to improve the output of fruiting bodies of Cordyceps militaris. The medium adding Nitrogen Source 4 is more beneficial to improve the output of fruiting bodies than that adding Nitrogen Source 1.
Two commonly used methods to detect polysaccharides were compared. The anthrone method was proved to be more accurate than the phenol-sulphuric acid method. The anthrone method has been modified. The color reaction of the modified anthrone method was still stable after four hours; furthermore, the system error was greatly reduced.
The extraction condition of polysaccharides was studied using fruiting bodies of Cordyceps militaris. An orthogonal experiment was employed based on four factors that affect the yield of polysaccharides including the extracting time and temperature, extracting times and the solid to solution ratio. The optimized condition to extract polysaccharides was established as extracted two times with 40 times volume of boiling water, two hours for each extraction.
The active component analysis showed that the production rate of polysaccharides was up to 15.25% in Medium 4, which was the most advantageous for the accumulation of polysaccharides in the fruiting body of Cordyceps militaris. The production rate of mannite was up to 7.00% in Medium 3, which was the best medium for accumulation of mannite in the fruiting body. Medium 1 was the most advantageous for accumulation of antioxidant substances in the fruiting body, the inhibitate rate of Pyrogallol auto-xidant of the liquid extracts from fruiting body was 62.12%.
Combine the above four analyses, the Medium 10 is the best medium to improve the total quality of Cordyceps militaris.
引文
Ahn Y J, et al. Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp [J]. Journal of Agricultural and Food Chemistry, 2000, 48(7): p. 2744-2748.
Berman J D. Inhibition of leishmanial protein kinase by antileish manial drugs [J]. Am J Trop Med Hyg, 1988, 38 (2): 298- 303.
Bok S H, Demain A L. An improved colorimetric assay for polyols [J]. Analytical Biochemistry, 1977, 81:(1): 18- 20.
Chang Y, et al. Effect of Cordyceps militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats [J]. The American Journal of Chinese Medicine, 2008, 36(5): p. 849- 859.
Chen Y, et al. Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers [J]. Cell Prolifiration, 2009, 42(6): 838- 847.
Cheung J K, et al. Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines [J]. Journal of Ethnopharmacology, 2009, 124(1): p. 61- 68.
Cho H J, et al. Cordycepin (3'-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner [J]. European Journal of Pharmacology, 2007, 558(1-3): p. 43- 51.
Cho H J, et al. Cordycepin (3'-deoxyadenosine) inhibits human platelet aggregation induced by U46619, a TXA2 analogue [J]. Journal of Pharmacy and Pharmacology, 2006, 58(12): p. 1677- 1682.
Cho H J,et al. Inhibitory effects of cordycepin (3'-deoxyadenosine), a component of Cordyceps militaris, on human platelet aggregation induced by thapsigargin [J]. Journal of Microbiology and Biotechnology, 2007, 17(7): p. 1134- 1138.
Choi S B, et al. Improvement of insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats [J]. Bioscience, Biotechnology and Biochemistry, 2004, 68(11): p. 2257- 2264.
Cunningham K G, et al. Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link [J]. Nature, 1950, 166 (4231): p. 949.
Deitch A D and Sawicki S G. Efects of cordycepin on microtubules of cultured mammalian cells [J]. Experimental Cell Research, 1979, 18 (1): 10- 13.
Hsu C H, et al. Effects of the immunomodulatory agent Cordyceps militaris on airway inflammation in a mouse asthma model [J]. Pediatrics and Neonatology, 2008, 49(5): p. 171- 178.
Hwang I K, et al. A Phytochemically characterized extract of Cordyceps militaris and cordycepin protect hippocampal neurons from ischemic injury in gerbils [J]. Planta Medica, 2008, 74(2): p. 114- 119.
JAM Chem Soc. Journal of the American [J]. Chemical Society, 1964, (86): 29- 52.
Jagger D V, Kredich N M, Guarino A J. Inhibition of Ehrlich mouse ascites tumor growth bycordycepin [J]. Cancer research, 1961, 21: p. 216- 220.
Jung E C, et al. A mushroom lectin from ascomycete Cordyceps militaris [J]. Biochimica etBiophysica Acta, 2007, 1770(5): p. 833- 838.
Kim J R, et al. Larvicidal activity against Plutella xylostella of cordycepin from the fruiting body ofCordyceps militaris [J]. Pest Management Science, 2002, 58(7): p. 713- 717.
Kim H G, et al. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression ofNF- B through Akt and p38 inhibition in RAW 264.7 macrophage cells [J]. European Journalof Pharmacology, 2006, 545(2): p. 192- 199.
Kim J S, et al. A fibrinolytic enzyme from the medicinal mushroom Cordyceps militaris [J]. JournalMicrobiology, 2006, 44(6): p. 622- 631.
Kim G Y, et al. Water extract of Cordyceps militaris enhances maturation of murine bonemarrow-derived dendritic cells in vitro [J]. Biological Pharmaceutical Bulletin, 2006, 29(2): p.354- 360.
Kim C S, et al. Cordyceps militaris induces the IL-18 expression via its promoter activation forIFN-gamma production [J]. Joural of Ethnopharmacol, 2008, 120(3): p. 366- 371.
Kodama E N, McCaffrey R P, Yusa K, Mitsuya H. Antileukemic Activity and Mechanism ofAction of Cordycepin against Termnal Deoxynucleotidal Transferase-Positive(TdT) leukemicCells [J]. Biochemical Pharmacology, 2000, (59): 273- 281.
Koh J H, Kim J M, Chang U J, et al. Hypochelesterolemic effect of hot-water extract from myceliaof Cordyceps sinensis [J]. Biological & Pharmaceutical Bulletin, 2003, 26 (1): 84- 87.
Kon J H, Kim K M, Kim J M, et al. Antifatigue and antistress effect of the hot-water extract Myceliaof Cordyceps sinensis [J]. Biological & Pharmaceutical Bulletin, 2003, 26 (5): 691- 694.
Ko W S, et al. Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability inanimal model [J]. Fitoterapia, 2010, 81(1): 1- 7.
Lee H, et al. Induction of apoptosis by Cordyceps militaris through activation of caspase-3 inleukemia HL-60 cells [J]. Biological Pharmaceutical Bulletin, 2006, 29(4): p. 670- 674.
Liu J, et al. Anticarcinogenic effect and hormonal effect of Cordyceps militaris Link [J]. ZhongguoZhong Yao Za Zhi, 1997, 22(2): p. 111- 113.
Lin W H, et al. Improvement of sperm production in subfertile boars by Cordyceps militarissupplement [J]. The American Journal of Chinese Medicine, 2007, 35(4): p. 631- 641.
Lo H C, et al. The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic ratsinduced by nicotinamide and streptozotocin [J]. Life Sciences, 2004, 74(23): p. 2897- 2908.
Lui J C, et al. Cordycepin induced eryptosis in mouse erythrocytes through a Ca~(2+)-dependentpathway without caspase-3 activation [J]. Molecular toxicology, 2007, 81(12): p. 859- 865.
Mathew P A, Ellis L K, Studzinski G P. Enhanced messenger RNA stability and differentiation ofHL 60 cels treated with 1, 25-di-hydroxyvitamin D3 and cordycep in.J Cell [J]. Physiol, 1989,140 (2): 212- 218.
Nan J X, et al. Antifibrotic effect of extracellular biopolymer from submerged mycelial cultures of Cordyceps militaris on liver fibrosis induced by bile duct ligation and scission in rats [J]. Archives of Pharmacal Research, 2001, 24(4): p. 327- 332.
Ohta Y, et al. In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans [J]. Journal of Agricultural and Food Chemistry, 2007, 55(25): p. 10194- 10199.
Park B T, et al. Antifungal and Anticancer Activities of a Protein from the Mushroom Cordyceps militaris [J]. Korean J Physiol Pharmacol, 2009. 13(1): p. 49- 54.
Park C, et al. Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis [J]. Oncology Report, 2005, 13(6): p. 1211- 1216.
Park S E, et al. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris [J]. Food and Chemical Toxicology, 2009, 47(7): p. 1667- 1675.
Plagemann P G. Efects of 32 deoxyadenosine (cordycepin) and 2-de-ox Tadenosine on udeoside transport, macromolecular synthesis, and replication of cultured Novlkof hepatoma cells [J]. Arch Biochem Bio2phys, 1971, 144 (1): 401- 412.
Rottman F and Guarino A J. The inhibition of purine biosynthesis be novo in Bacillus subtilis by cordycepin [J]. Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1964, 80(4): p. 640- 647.
Rukachaisirikul V, et al. 10-membered macrolides from the insect pathogenic fungus Cordyceps militaris BCC 2816 [J]. Journal of natural products, 2004, 67(11): p. 1953- 1955.
Shen Q and Chen S. Effect of Cordyceps militaris on the damage of rats induced by n-hexane [J]. Zhong Yao Cai, 2001, 24(2): p. 112- 116.
Shen Y D, et al. Cordyceps sinensis polysaccharide enhances apoptosis of HL-60 cells induced by triptolide [J]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2009, 38(2): p. 158- 162.
Sinha R, Radha C, Prakash J, et al. Whey protein hydrolysate: Functional properties, nutritional quality and utilization in beverage formulation [J]. Food Chemistry, 2007, 101, (4): 1484- 1491.
Shimada T, et al. Suppression of adipocyte differentiation by Cordyceps militaris through activation of the aryl hydrocarbon receptor [J]. American journal of physiology. Endocrinology and metabolism, 2008, 295(4): p. 859- 867.
Shi P, et al. Proteomic detection of changes in protein expression induced by cordycepin in human hepatocellular carcinoma BEL-7402 cells [J]. Methods Find Exp Clin Pharmacol, 2008, 30(5): p. 347- 353.
Siev M, Weinberg R and Penman S. The selective interruption of nucleolar RNA synthesis in HeLa cells by cordycepin [J]. The Journal of cell biology, 1969, 41(2): p. 510- 520.
Wang Z S, Gu Y X and Yuan Q S. Effect of nutrition factors on the synthesis of superoxide dismutase, catalase, and membrane lipid peroxide levels in Cordyceps militaris mycelium [J].Curr Microbiol, 2006, 52(1): p. 74- 79.
Wang X B, Liu P and Tang Z P. Intervening and therapeutic effect of cordyceps mycelia extract on liver cirrhosis induced by dimethylnitrosamine in rats [J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2008, 28(7): p. 617- 622.
Wang X B, et al. Cordyceps mycelia extract decreases portal hypertension in rats with dimethylnitrosamine-induced liver cirrhosis: a study on its histological basis [J]. Zhong Xi Yi Jie He Xue Bao, 2008, 6(11): p. 1136- 1144.
Won K J, et al. Cordycepin attenuates neointimal formation by inhibiting reactive oxygen species-mediated responses in vascular smooth muscle cells in rats [J]. Journal of Pharmacological Sciences, 2009, 109(3): p. 403- 412.
Wong J H, Wang H and Ng T B. A hemagglutinin from the medicinal fungus Cordyceps militaris [J]. Bioscience Report, 2009, 29(5): 321- 327.
Won S. and Park E. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris [J]. Journal of Ethnopharmacology, 2005, 96(3): p. 555- 561.
Wu A M, et al. Cordycepin inhibits induction of murine leukovirus production by 5-iodo-2'-deoxyuridine [J]. Proceedings of the National Academy of Sciences of the United States of America, 1972, 69(12): p. 3820- 3824.
W Zhao-Long, W Xiao-Xia and C Wei-Ying. Inhibitory effect of Cordyceps sinensis and Cordyceps militaris on human glomerular mesangial cell proliferation induced by native LDL [J]. Cell Biochemistry Function, 2000, 18(2): p. 93- 97.
Xia S H, Wang Z, Xu S Y. Characteristics of Bellamya purificata snailfoot protein and enzymatic hydrolysates [J]. Food Chemistry, 2007, 101(3): 1188- 1196.
Yoshikawa, N,et al.Cordycepin (3'-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression [J]. Naunyn Schmiedebergs Arch Pharmacol, 2008, 377(4-6): p. 591- 595.
Yoo H S, et al. Effects of Cordyceps militaris extract on angiogenesis and tumor growth [J]. Acta Pharmacological Sinica, 2004, 25(5): p. 657- 665.
Yu H M, et al. Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage [J]. Journal of Agricultural and Food Chemical, 2006, 54(8): p. 3132- 3138.
Yue G G, et al. Effects of Cordyceps sinensis, Cordyceps militaris and their isolated compounds on ion transport in Calu-3 human airway epithelial cells [J]. Journal of Ethnopharmacology, 2008, 117(1): p. 92- 101.
Yu R M, Song L Y, Zhao Y, et al. Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris [J]. Fitoterapia, 2004, 75: 465- 472.
Yu R M, Wang L, Zhang H, et al. Isolation purification and identificationof polysaccharides from cultured Cordyceps militaris [J]. Fitoterapia, 2004, 75: 662- 666.
Yu R M, Yang W, Song L Y, et al. Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris [J]. Carbohydrate Polymers, 2007, 70: 430- 436.
Yu R M, Yin Y, Yang W, et al. Structural elucidation and biological activity of a novel polysaccharide by alkaline extraction from cultured Cordyceps militaris [J]. Carbohydrate Polymers, 2008, 10 (7): 23.
Yu R, et al. Structural elucidation and biological activity of a novel polysaccharide by alkaline extraction from cultured Cordyceps militaris [J]. Carbohydrate Polymers, 2009, 75(1): p. 166- 171.
Yu R, et al. Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris [J]. Carbohydrate Polymers, 2007, 70(4): p. 430- 436.
Zhong M, et al. Effect of selenium-protein polysaccharide extracted from Se-rich Cordyceps militaris on tumor-bearing mice [J]. Zhongguo Zhong Yao Za Zhi, 2008, 33(18): p. 2120- 2123.
陈磊,蛹虫草(Cordyceps militaris)生物学特性及发酵研究[D].中国协和医科大学,2009,58- 59.
白霞,尹莲花,冯艳伟.微波法在蛹虫草多糖提取中的应用[J].大连民族学院学报,2005,(3):96.
宾文,等.人工培养蛹虫草多糖的抗炎及免疫作用研究[J] .时珍国医国药,2003,14(1):1- 2.
蔡仲军,尹定华,秦松云.水提取法测定冬虫夏草中甘露醇的含量[J].重庆教育学报,2002b,15(6):42- 44.
蔡仲军,尹定华,秦松云.不同预处理对冬虫夏草中甘露醇的含量测定的影响[J].广西中医学院学报,2002,5(4):75- 77.
柴建萍,白兴荣,谢道燕.蛹虫草主要有效成分及其药理功效[J].云南农业科技,2003(4):22- 23.
曹丽茹,等.蛹虫草栽培应用研究[J].辽宁林业科技,2006,(2):25,39,F3.
常雅宁,等.两种连苯三酚自氧化法测定超氧化物歧化酶的比较[J].药物分析杂志,2001,(05):328- 331.
陈敬民,李友娣,疗驱等.蛹虫草的镇静催眠作用[J].中药药理与临床,1997,13(6):44- 45.
陈文冬,杨文礼.蛹虫草对运动训练大鼠血清激素水平及运动能力影响的研究[J].西安体育学院学报,2008,(04):86- 89.
崔新颖,崔新羽,张成义.新型蚕蛹虫草对小鼠免疫增强作用的实验研究[J].北华大学学报:自然科学版,2004,5(5)405- 407.
戴瑛,等.蛹虫草提取物对内毒素引起小鼠急性肺损伤的保护作用[J].中国临床药理学与治疗学,2004,9(4):386- 388.
董彩虹.冬虫夏草多糖的研究进展[J].食品科学,2004,25(7)195- 198.
杜鸣,梁芳珍.流动注射-光度法测定超氧阴离子自由基(02-)与超氧化物歧化酶(SOD)活性的研究[J].高等学校化学学报,1999,20(3)369- 373.
冯景刚,刘影.不同培养基配方培养北虫草试验[J].食用菌, 2008,(6):27- 28.
付呜佳.蛹虫草产类胡萝卜素的研究[J].食品与生物技术学报,2005,24(5):107- 110.
韩永萍,林强与何绪文.虫草菌丝体多糖的提取研究[J].食用菌,2007,(6):53- 55.
黄德娟,黄德超.生物活性肽[J].生物学通报,2006,41(4):17- 18.
何次平.蛹虫草米饭栽培工艺要领[J].食用菌,2003,(S1):35- 36.
何洋,等.蛹虫草优化培养研究进展[J].鲁东大学学报(自然科学版),2011,(1):64- 70.
华宁烨,等.富锗蛹虫草无性型乙醇分级多糖抗氧化能力研究[J].徐州工程学院学报(自然科学版),2010(3):61- 66,84.
孔凡海.蛹虫草栽培技术[J].农业知识:瓜果菜,2005,(1):32.
高平.蛹虫草优质高产栽培技术[J].吕梁高等专科学校学报,2007(1):15- 17.
葛新,白小红,李云兰.分光光度计测定蛹虫草D-甘露醇的含量[J].山西医科大学学报,2001,32(4):317- 318.
盖新杰,张伸翼.蛹虫草胞外多糖的研究I半乳甘露聚糖CM-1的纯化和结构研究[J].真菌学报,1992,11(4):300- 307.
古培总,刘飞凤,陈逸湘.蛹虫草高产栽培技术[J].广东农村实用技术,2005,(1):15.
郭晓蕾,等.硫酸蒽酮法与硫酸苯酚法测定灵芝多糖含量比较[J].中华中医药学刊,2010,28(9):2000- 2002.
焦彦朝,梁宗琦,刘爱英,等.虫草生物活性物质研究概况[J].贵州农业科学,1990,(3):53- 58.
江晓路,葛蓓蕾.北虫草菌Y3胞内与胞外多糖的免疫药理研究[J].青岛海洋大学学报,1998,28(2)192- 197.
江晓路,葛蓓蕾,胡晓坷.蛹虫草对药物引起免疫抑制的拮抗作用[J].青岛海洋大学学报,2002,32(l):46- 50.
江晓路,孙月.蛹虫草活性成分的测定[J].食用菌学报,1999,6(01):47- 50.
金凌云,杜双田,马璐,等.蛹虫草栽培基质的模型优化研究[J].西北农林科技大学学报:自然科学版,2009,(11):175- 179.
金凌云,等.蛹虫草栽培基质的模型优化研究[J].西北农林科技大学学报:自然科学版,2009,37(11):175- 179.
金峰.抑瘤多糖-LAK强剂[J].中国肿瘤临床,1996,23(6):433- 436.
金永日.蚕蛹虫草和冬虫夏草中D-甘露醇的分析[J].白求恩医科大学学报,1992,18(1):47- 48.
连云岚,杨中林.北虫草化学成分及药理作用研究进展[J].山西医药杂志,2006,35(1):44- 46.
廖春丽,等.蛹虫草主要有效成分分析[J].安徽农业科学,2008,36(12):5050- 5052.
李春丽,刘晓兰,陈慧鑫,等.蛹虫草深层培养产菌丝体及胞外多糖的初步研究[J].农产品加工(创新版),2010(2):22- 26.
李华为,赵素云,铁梅.富硒蛹虫草抗氧化作用研究[J].食品科学,2010(23):61- 64.
李连德,李增智,樊美珍.虫草多糖研究进展.安徽农业大学学报[J],2000,27(4):413- 416.
李连德,樊美珍,李增智.14种虫草多糖对果蝇成虫寿命影响的实验[J].微生物学通报,2000,27(6)427- 428.
李楠,等.蛹虫草与冬虫夏草化学成分比较[J].吉林农业大学学报,1995,(S1):80- 83.
李雪芹,包天桐,王雁.比色法测定冬虫夏草中甘露醇的含量[J].中草药,1999x,30(1):1921.
李雪芹,熊功有.不同方法测定29种中药甘露醇含量的比较研究[J].九江医学,1999b,14(1):25- 27.
李雪芹,张磊,熊功友.比色法与容量法测定冬虫夏草中甘露醇含量比较研究[J].九江医学,1998,(4):10- 13.
李雪芹,包天桐,王雁.比色法测定冬虫夏草中甘露醇的含量[J].中草药,1999,(1):19- 21.
李信,许雷,裴鑫德.蛹虫草(Cordyceps militaris)菌丝体液体培养基的优化和发酵条件的研究[J].核农学报,1998,(1):36- 41.
李信,许雷.蛹虫草产生的胞外多糖及其理化性能和抗氧化活性的初步研究[J].微生物学杂志,1997,17(3):13- 17.
李信,许雷.蛹虫草菌胞外多糖发酵工艺优化[J].化工冶金,1998,19(3):63- 68.
李欣,等.蛹虫草子实体水提取物对辐射损伤的保护作用研究[J].华南预防医学,2006,32(3)58- 60.
李宗军,温琼英.蛹虫草无性型的研究II.液体发酵培养菌丝体及胞外多糖的提制[J].湖南农业大学学报,1998,(5):38- 42.
梁正岐.蛹虫草月饼及其制作方法:中国,CN1911052[P].2007-02-14.
凌宏通,等.蛹虫草的富硒栽培技术初步研究[J].中国食用菌,2006,25(4)52- 53.
林群英,等.蛹虫草人工栽培条件优化研究[J].中国食用菌,2006,25(6):17- 19.
林庆斌,等.超氧化物歧化酶(SOD)的研究和应用进展[J].化学世界,2006(06):378- 381.
刘春泉,等.北冬虫夏草超微粉对小鼠免疫功能的增强作用[J].江苏农业学报,2007,23(1):63- 66.
刘春泉,等.微波法提取北冬虫夏草中黄酮类化合物.江苏农业学报,2007,23(4):356- 359.
刘红锦,等.蛹虫草多糖提取及纯化工艺研究[J].江西农业学报,2007,19(12):80- 82.
刘刚,国内蛹虫草研究现状.中国中医药信息杂志[J],1994(1):23- 24.
刘建荣,静天玉.超氧化物歧化酶的两种邻苯三酚测活法比较[J].中国生化药物杂志,1996,17(06):234- 237.
刘晓涵,等.蒽酮硫酸法与苯酚硫酸法测定枸杞子中多糖含量的比较[J].食品科技,2009,34(9):270- 272.
刘群.2型糖尿病患者血清超氧化物歧化酶与丙二醛含量的测定及其临床意义[J].河北医药,2001,23(9):66- 67.
刘维兰.食管癌患者血清SOD活性MDA水平变化及其临床意义[J].肿瘤研究与临床,2000,7(5):270- 271.
陆军,滕利荣,程瑛琨,孟庆繁.北虫草多肽纳米系列护肤化妆品及其制备方法:中国,CN1709220[P].2005-12-21.
鲁晓岩.硫酸-苯酚法测定北冬虫夏草多搪含量[J].食品工业科技,2002,23(4):69- 70.
吕子明,等.人工蛹虫草子实体化学成分研究[J].中国中药杂志,2008,34(24):2914- 2917.
孟兆丽,等.蛹虫草多糖抑菌及抗氧化作用研究[J].食品研究与开发,200829(09):31- 33.
马成坚,顾亚萍,芦青.百令胶囊中虫草多糖的提取和含量测定[J].浙江中医学院学报,2004,28(4):81- 82.
孟繁宇.蛹虫草高产菌株人工栽培条件的优化[J].食用菌,2009(4):55-56.
穆忠平.蛹虫草高产栽培技术[J].食用菌,2004,26(5):36.
潘新群,等.蛹虫草菌液体发酵工艺的研究[J].江西农业学报,2006(1):30- 34.
潘新法,蛹虫草子实体的人工培育及超氧化物歧化酶的活性测定[J].食用菌学报,1995,2(03):25- 28.
彭国平,李红阳,袁永泰.冬虫夏草与人工蛹虫草的成分比较[J].南京中医药大学学报,1996,12(5):26- 27.
钱素英.恶性血液病患者血一氧化氮、内皮素及超氧化物歧化酶的变化[J].肿瘤学杂志,2002,7(5):270- 271.
秦秀丽,杨国会,李风林.蛹虫草液体深层发酵的研究[J].北方园艺,2010(23):167- 170.
秦建春,等.蛹虫草发酵液抗菌活性初步研究[J].西北植物学报,2006,26(2):402- 406.
曲友直,赵振伟,高国栋,等.甘露醇对局灶性脑缺血再灌注大鼠脑组织NO及神经细胞凋亡的影响[J].卒中与神经疾病,2004,11(1):812.
阮桂平,彭拓华.冬虫夏草及其类似品中甘露醇的含量研究概况[J].江西中医学院学报, 2001.13(2):96,F3.
施明珠,等.北冬虫夏草对氢化可的松诱导的老龄小鼠肾损伤的保护作用[J].现代药物与临床,2009,24(03):160- 163.
施明珠,等.蛹虫草菌丝体醇提物对氢化可的松致小鼠肝损伤的保护作用[J].中草药,2009,40(02):262- 265.
施英,等.微波辅助提取蚕蛹虫草多糖的研究[J].广东农业科学,2006,(11):41- 42.
锁现民,蔡树威,张现法.浅谈蛹虫草栽培菌种制作及鉴定[J].食用菌,2009,(4):41.
孙成秀,廖纪录,龙小慧,等.甘露醇的临床新用途[J].新医学,1996,27(1):41- 42.
孙悦迎,张旭东.冬虫夏草与蛹虫草特性分析[J].中医药学报,2002,30(02):43- 44.
孙艳,官杰,王琪.人工蛹虫草子实体对荷肝癌小鼠的抑瘤作用及提高NK,IL-2活性的实验研究[J].药物研究,2002,11(7)39- 40.
孙叶,等.蛹虫草规模化人工栽培技术要点[J].江苏农业科学,2008,(6):145- 146.
铁梅,等.蛹虫草富硒栽培特性的研究[J].食用菌,2005,27(4):38- 39.
铁梅,等.硒对蛹虫草生长发育的影响[J].辽宁大学学报(自然科学版),2005(1)25- 27.
万晓星,等.中草药对蛹虫草液体深层发酵的影响[J].大连轻工业学院学报,1998,17(4):6- 11.
王宝贵,张桂英,赵林伊.柞蚕蛹虫草对黑腹果蝇寿命的影响[J].中国老年学杂志,2002,22(3):148-150.
王炳娟,李玲霞,邹洪.邻苯三酚自氧化法测定SOD活性的电化学研究[J].研究报告,2008:(2)29,38.
王化远,唐心.川产野生冬虫夏草不同生长期子座虫体中甘露醇含量比较[J].华西医药杂志,1996b,11(1):58- 59.
王刚,麻兵继,刘吉开.人工蛹虫草化学成分研究[J].中草药,2004,35(5)493- 495.
王琳,王炯,杨继红,尹家元.固相萃取高效液相色普测定冬虫夏草的甘露醇[J].分析实验室,2003,22(6):83- 85.
王菊凤,李鹄鸣.蛹虫草多糖对果蝇寿命影响的研究[J].中国野生植物资源,2008,27(03):38- 41.
王菊凤,杨道德,李鹊呜,等.虫草多糖的研究进展[J].中草药,2006,37(5):6- 8.
王建芳,杨春清.蛹虫草有效成分及药理作用研究进展[J].中医药信息,2005,22(5):30- 32.
王琦.野生蛹虫草与培植蛹虫草清除·OH自由基作用的对比研究[J].辽宁师专学报(自然科学版),2002,(3):43- 45.
王琦,韩晓龙.蛹虫草对老年大鼠自由基代谢影响的研究[J].辽宁师专学报(自然科学版),2002,(4):104- 106.
王琦,韩晓龙,蛹虫草对老年大鼠自由基代谢影响的研究[J].辽宁师专学报,2002,4(2):104- 106.
王雅玲,郑双双,吕国忠,等.我国蛹虫草人工栽培培养基的现状调查[J].食用菌,2009,31(1):1- 2.
王英臣.关于蛹虫草菌多糖发酵及培养基的研究[J].中国酿造,2005(10):29- 31.
王英娟,等.蛹虫草中虫草素、虫草多糖综合提取工艺研究[J].西北植物学报,2005,25(9):1863- 1867.
王栩,刘守华.蛹虫草的代料栽培试验[J].食用菌,2003,25(1):23- 23.
汪宝琪,庞志功.西藏冬虫夏草中D-甘露醇的薄层扫描分析[J].中草药,1995,26(4):189- 190.
武忠伟,等.冬虫夏草和蛹虫草发酵液抗菌活性研究[J].微生物学杂志,2008,28(4):47- 50.
肖代敏,等.药用虫草中甘露醇、多糖的高通量测定及提制工艺[J].食品科学,2010,31(6):11- 15.
薛建娥,冉翠香.蛹虫草人工栽培种的分离与复壮[J].食用菌,2002,24(2):17- 18.
向德军,等.常用真菌类中药清除酶自由基的活力测定[J].药学实践杂志,2000,18(05):286-287.
向会耀,方华舟.不同氮源对蛹虫草菌丝及子实体生长状况的影响[J].湖北农业科学,2010,49(11)2734- 2736.
谢卫华,姚菊芳,袁勤生.连苯三酚自氧化法测定超氧化物歧化酶活性的改进[J].医药工业,1988,19(5):217- 219.
邢振荣,王溶溶,沈雁书,等.冬虫夏草菌体成分分析[J].中成药研究,1986,26(4):189- 191.
徐维蓉,等.人工栽培北冬虫夏草子实体对大鼠下丘脑GnRH细胞mRNA表达的调节作用[J].上海中医药杂志,2009,43(07):72- 74.
徐靖,杨秀岑.邻苯三酚-鲁米诺发光体系测定SOD活性[J].郧阳医学院学报,1999,18(2):68- 69.
许周善,周晓燕.冬虫夏草多搪的研究进展[J].工业微生物,2000,30(1):56- 57.
宣华.不同氮源对北冬虫夏草生长影响的研究[J].佛山科学技术学院学报(自然科学版),2008,26(3):52- 54.
阎家麟,朱建梅,桂兴芬等.牛血铜锌超氧化物歧化酶制备工艺的该进[J].中国医药工业杂志,1992,23(11):481- 483.
闫喜涛,包海鹰,图力古尔.人工培养蛹虫草中一种天然色素的分离和结构鉴定[J].菌物学报,2010(5):777- 781.
杨明琰,等.超氧化物歧化酶两种邻苯三酚自氧化测定活力方法的比较[J].微生物学杂志,2006,26(03):40- 43.
姚倩,孙涛,徐轶霞,等.壳聚糖/壳寡糖衍生物的制备及其抗氧化性能研究[J].食品与生物技术学报,2009,28(2):188- 189.
岳春.蛹虫草保健茶饮料的研制[J].中国酿造,2008,(18):86- 89.
岳春,等.蛹虫草菌保健黄酒的研究[J].酿酒科技,2006,148(10):70- 73.
颜辉,朱冬吉,吴杰.超声波辅助提取蛹虫草多糖的研究[J].江苏农业科学,2009,(1):255- 257.
余丽霞,张冰冰,阮叶萍等.虫草多糖不同组分的免疫活性研究.浙江中医学院学报[J],2004,28(l):49- 50.
袁勤生,王志友,翁清清,等.邻苯三酚自氧化法测定超氧化物歧化酶的活性[J].医药工业杂志,1983,(1):16- 19.
赵丰丽与林严.北冬虫夏草保健酱油的研制[J].中国酿造,2006,162(9):75- 77.
赵丰丽,等.北冬虫夏草保健茶饮料的研制[J].食品工业科技,2007,28(1):132- 134.
赵志君,等.蛹虫草子实体保健酒的研制[J].酿酒,2007,34(06):67- 69.
张博润,田宇清,黄英等.酵母超氧化物歧化酶高产菌选育[J].微生物学报,1994,34(4): 280.
张金艳.蛹虫草人工培养技术及其主要有效成分调控的研究[D].西南大学,2010,67- 70.
张妙霞,等.蒽酮法测定可溶性糖显色条件的研究[J].洛阳农专学报,1997,17(4):24- 28.
张海娟,王文洁,张兵.蚕蛹虫草对巨噬细胞吞噬功能的作用[J].山西职工医学院学报,2008,(04):16- 17.
张海英,比色法测定蒙山九州虫草中甘露醇的含量[J].安徽农业科学,2007,35(27):8523- 8537.
张显科,刘文霞.蛹虫草化学成份测定[J].菌物系统,1997,16(1):78- 80.
张小强,浦跃朴,尹立红,等.冬虫夏草及人工虫草菌丝体对超氧阴离子自由基和轻自由基清除作用的实验研究[J].中国老年学杂志.2003,23(11):773- 775.
张晓燕.超氧化物歧化酶的研究现状及在食品中的应用综述[J].扬州职业大学学报,2002,6(1):90- 95.
张秀娟,等.蛹虫草提取物对H22小鼠抗氧化能力的影响[J].时珍国医国药,2008,19(04):943- 944.
张绪璋.北冬虫夏草的人工培植及其营养成分分析[J].中国食用菌,2002,22(2):19- 21.
赵怡红,吴玲.不同豆类氮源对北冬虫夏草生长影响的研究[J].青海师范大学学报(自然科学版),2009,(2):52- 55.
赵彩云,安冬,张华彬.蛹虫草的栽培技术[J].上海蔬菜,2007,(3):86.
郑婷婷,等.蛹虫草液体培养条件优化及有效成分含量分析[J].菌物研究,2004(4)22- 25.
周广麟,蛹虫草的液体培养(发酵)技术[J].中国食物与营养,2000,(2):26- 27.
邹向英.3种虫草活性成分的对比分析[J].东北农业大学学报,2010,41(7):139- 142.
左志宇,等.蛹虫草菌丝体循环富硒法的建立及其硒多糖抑癌作用初探[J].食用菌, 2008,(03):9- 11.
钟裕容,等.蛹虫草菌丝与冬虫夏草中氨基酸、甘露醇的含量[J].中国中药杂志,1990,(4):39- 40.
朱蕴兰,等.蛹虫草酸奶饮料的研制[J].食品科技, 2008,(10):91- 92.
左克源,等.人工蛹虫草子实体对小鼠免疫功能的影响[J].医药导报,2007,26(3):227- 229.
宋福兴.一种蛹虫草酒及其制备方法:中国,CN200810228178.6[P].2009-04-01.
时闻讯.北虫草营养酒及其酿制方法:中国,CN101363000[P].2009-02-11.
江苏省植物研究所等编著.新华本草纲要[M].上海:上海科学技术出版社,1991:681.
敬一兵,陆鲁生.虫草[M].昆明:云南科技出版社,1986:156.
王国栋.冬虫夏草类:生态、培植、引用[M].北京:科学技术文献出版社,1995:307.
苏哈道尼克.核苷类抗菌素[M].其明,王恕蓉译.北京:科学出版社,1982:476.
邵力平,等编.真菌分类学[M].北京:中国林业出版社,1984:370.
冉先德主编.中华药海[M].北京:哈尔滨出版社,1993:1033- 1872.
徐锦堂.中国药用真菌学[M].北京:北京医科大学及中国协和医科大学联合出版社,1997:394- 400.
中国科学院中国孢子植物志编辑委员会编辑梁宗琦主编.中国真菌志[M].北京:科学出版社,2007:第三十二卷,虫草属.
Berman J D. Inhibition of leishmanial protein kinase by antileish manial drugs [J]. Am J Trop Med Hyg, 1988, 38 (2): 298- 303.
Bok S H, Demain A L. An improved colorimetric assay for polyols [J]. Analytical Biochemistry, 1977, 81:(1): 18- 20.
Chang Y, et al. Effect of Cordyceps militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats [J]. The American Journal of Chinese Medicine, 2008, 36(5): p. 849- 859.
Chen Y, et al. Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers [J]. Cell Prolifiration, 2009, 42(6): 838- 847.
Cheung J K, et al. Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines [J]. Journal of Ethnopharmacology, 2009, 124(1): p. 61- 68.
Cho H J, et al. Cordycepin (3'-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner [J]. European Journal of Pharmacology, 2007, 558(1-3): p. 43- 51.
Cho H J, et al. Cordycepin (3'-deoxyadenosine) inhibits human platelet aggregation induced by U46619, a TXA2 analogue [J]. Journal of Pharmacy and Pharmacology, 2006, 58(12): p. 1677- 1682.
Cho H J,et al. Inhibitory effects of cordycepin (3'-deoxyadenosine), a component of Cordyceps militaris, on human platelet aggregation induced by thapsigargin [J]. Journal of Microbiology and Biotechnology, 2007, 17(7): p. 1134- 1138.
Choi S B, et al. Improvement of insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats [J]. Bioscience, Biotechnology and Biochemistry, 2004, 68(11): p. 2257- 2264.
Cunningham K G, et al. Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link [J]. Nature, 1950, 166 (4231): p. 949.
Deitch A D and Sawicki S G. Efects of cordycepin on microtubules of cultured mammalian cells [J]. Experimental Cell Research, 1979, 18 (1): 10- 13.
Hsu C H, et al. Effects of the immunomodulatory agent Cordyceps militaris on airway inflammation in a mouse asthma model [J]. Pediatrics and Neonatology, 2008, 49(5): p. 171- 178.
Hwang I K, et al. A Phytochemically characterized extract of Cordyceps militaris and cordycepin protect hippocampal neurons from ischemic injury in gerbils [J]. Planta Medica, 2008, 74(2): p. 114- 119.
JAM Chem Soc. Journal of the American [J]. Chemical Society, 1964, (86): 29- 52.
Jagger D V, Kredich N M, Guarino A J. Inhibition of Ehrlich mouse ascites tumor growth bycordycepin [J]. Cancer research, 1961, 21: p. 216- 220.
Jung E C, et al. A mushroom lectin from ascomycete Cordyceps militaris [J]. Biochimica etBiophysica Acta, 2007, 1770(5): p. 833- 838.
Kim J R, et al. Larvicidal activity against Plutella xylostella of cordycepin from the fruiting body ofCordyceps militaris [J]. Pest Management Science, 2002, 58(7): p. 713- 717.
Kim H G, et al. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression ofNF- B through Akt and p38 inhibition in RAW 264.7 macrophage cells [J]. European Journalof Pharmacology, 2006, 545(2): p. 192- 199.
Kim J S, et al. A fibrinolytic enzyme from the medicinal mushroom Cordyceps militaris [J]. JournalMicrobiology, 2006, 44(6): p. 622- 631.
Kim G Y, et al. Water extract of Cordyceps militaris enhances maturation of murine bonemarrow-derived dendritic cells in vitro [J]. Biological Pharmaceutical Bulletin, 2006, 29(2): p.354- 360.
Kim C S, et al. Cordyceps militaris induces the IL-18 expression via its promoter activation forIFN-gamma production [J]. Joural of Ethnopharmacol, 2008, 120(3): p. 366- 371.
Kodama E N, McCaffrey R P, Yusa K, Mitsuya H. Antileukemic Activity and Mechanism ofAction of Cordycepin against Termnal Deoxynucleotidal Transferase-Positive(TdT) leukemicCells [J]. Biochemical Pharmacology, 2000, (59): 273- 281.
Koh J H, Kim J M, Chang U J, et al. Hypochelesterolemic effect of hot-water extract from myceliaof Cordyceps sinensis [J]. Biological & Pharmaceutical Bulletin, 2003, 26 (1): 84- 87.
Kon J H, Kim K M, Kim J M, et al. Antifatigue and antistress effect of the hot-water extract Myceliaof Cordyceps sinensis [J]. Biological & Pharmaceutical Bulletin, 2003, 26 (5): 691- 694.
Ko W S, et al. Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability inanimal model [J]. Fitoterapia, 2010, 81(1): 1- 7.
Lee H, et al. Induction of apoptosis by Cordyceps militaris through activation of caspase-3 inleukemia HL-60 cells [J]. Biological Pharmaceutical Bulletin, 2006, 29(4): p. 670- 674.
Liu J, et al. Anticarcinogenic effect and hormonal effect of Cordyceps militaris Link [J]. ZhongguoZhong Yao Za Zhi, 1997, 22(2): p. 111- 113.
Lin W H, et al. Improvement of sperm production in subfertile boars by Cordyceps militarissupplement [J]. The American Journal of Chinese Medicine, 2007, 35(4): p. 631- 641.
Lo H C, et al. The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic ratsinduced by nicotinamide and streptozotocin [J]. Life Sciences, 2004, 74(23): p. 2897- 2908.
Lui J C, et al. Cordycepin induced eryptosis in mouse erythrocytes through a Ca~(2+)-dependentpathway without caspase-3 activation [J]. Molecular toxicology, 2007, 81(12): p. 859- 865.
Mathew P A, Ellis L K, Studzinski G P. Enhanced messenger RNA stability and differentiation ofHL 60 cels treated with 1, 25-di-hydroxyvitamin D3 and cordycep in.J Cell [J]. Physiol, 1989,140 (2): 212- 218.
Nan J X, et al. Antifibrotic effect of extracellular biopolymer from submerged mycelial cultures of Cordyceps militaris on liver fibrosis induced by bile duct ligation and scission in rats [J]. Archives of Pharmacal Research, 2001, 24(4): p. 327- 332.
Ohta Y, et al. In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans [J]. Journal of Agricultural and Food Chemistry, 2007, 55(25): p. 10194- 10199.
Park B T, et al. Antifungal and Anticancer Activities of a Protein from the Mushroom Cordyceps militaris [J]. Korean J Physiol Pharmacol, 2009. 13(1): p. 49- 54.
Park C, et al. Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis [J]. Oncology Report, 2005, 13(6): p. 1211- 1216.
Park S E, et al. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris [J]. Food and Chemical Toxicology, 2009, 47(7): p. 1667- 1675.
Plagemann P G. Efects of 32 deoxyadenosine (cordycepin) and 2-de-ox Tadenosine on udeoside transport, macromolecular synthesis, and replication of cultured Novlkof hepatoma cells [J]. Arch Biochem Bio2phys, 1971, 144 (1): 401- 412.
Rottman F and Guarino A J. The inhibition of purine biosynthesis be novo in Bacillus subtilis by cordycepin [J]. Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1964, 80(4): p. 640- 647.
Rukachaisirikul V, et al. 10-membered macrolides from the insect pathogenic fungus Cordyceps militaris BCC 2816 [J]. Journal of natural products, 2004, 67(11): p. 1953- 1955.
Shen Q and Chen S. Effect of Cordyceps militaris on the damage of rats induced by n-hexane [J]. Zhong Yao Cai, 2001, 24(2): p. 112- 116.
Shen Y D, et al. Cordyceps sinensis polysaccharide enhances apoptosis of HL-60 cells induced by triptolide [J]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2009, 38(2): p. 158- 162.
Sinha R, Radha C, Prakash J, et al. Whey protein hydrolysate: Functional properties, nutritional quality and utilization in beverage formulation [J]. Food Chemistry, 2007, 101, (4): 1484- 1491.
Shimada T, et al. Suppression of adipocyte differentiation by Cordyceps militaris through activation of the aryl hydrocarbon receptor [J]. American journal of physiology. Endocrinology and metabolism, 2008, 295(4): p. 859- 867.
Shi P, et al. Proteomic detection of changes in protein expression induced by cordycepin in human hepatocellular carcinoma BEL-7402 cells [J]. Methods Find Exp Clin Pharmacol, 2008, 30(5): p. 347- 353.
Siev M, Weinberg R and Penman S. The selective interruption of nucleolar RNA synthesis in HeLa cells by cordycepin [J]. The Journal of cell biology, 1969, 41(2): p. 510- 520.
Wang Z S, Gu Y X and Yuan Q S. Effect of nutrition factors on the synthesis of superoxide dismutase, catalase, and membrane lipid peroxide levels in Cordyceps militaris mycelium [J].Curr Microbiol, 2006, 52(1): p. 74- 79.
Wang X B, Liu P and Tang Z P. Intervening and therapeutic effect of cordyceps mycelia extract on liver cirrhosis induced by dimethylnitrosamine in rats [J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2008, 28(7): p. 617- 622.
Wang X B, et al. Cordyceps mycelia extract decreases portal hypertension in rats with dimethylnitrosamine-induced liver cirrhosis: a study on its histological basis [J]. Zhong Xi Yi Jie He Xue Bao, 2008, 6(11): p. 1136- 1144.
Won K J, et al. Cordycepin attenuates neointimal formation by inhibiting reactive oxygen species-mediated responses in vascular smooth muscle cells in rats [J]. Journal of Pharmacological Sciences, 2009, 109(3): p. 403- 412.
Wong J H, Wang H and Ng T B. A hemagglutinin from the medicinal fungus Cordyceps militaris [J]. Bioscience Report, 2009, 29(5): 321- 327.
Won S. and Park E. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris [J]. Journal of Ethnopharmacology, 2005, 96(3): p. 555- 561.
Wu A M, et al. Cordycepin inhibits induction of murine leukovirus production by 5-iodo-2'-deoxyuridine [J]. Proceedings of the National Academy of Sciences of the United States of America, 1972, 69(12): p. 3820- 3824.
W Zhao-Long, W Xiao-Xia and C Wei-Ying. Inhibitory effect of Cordyceps sinensis and Cordyceps militaris on human glomerular mesangial cell proliferation induced by native LDL [J]. Cell Biochemistry Function, 2000, 18(2): p. 93- 97.
Xia S H, Wang Z, Xu S Y. Characteristics of Bellamya purificata snailfoot protein and enzymatic hydrolysates [J]. Food Chemistry, 2007, 101(3): 1188- 1196.
Yoshikawa, N,et al.Cordycepin (3'-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression [J]. Naunyn Schmiedebergs Arch Pharmacol, 2008, 377(4-6): p. 591- 595.
Yoo H S, et al. Effects of Cordyceps militaris extract on angiogenesis and tumor growth [J]. Acta Pharmacological Sinica, 2004, 25(5): p. 657- 665.
Yu H M, et al. Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage [J]. Journal of Agricultural and Food Chemical, 2006, 54(8): p. 3132- 3138.
Yue G G, et al. Effects of Cordyceps sinensis, Cordyceps militaris and their isolated compounds on ion transport in Calu-3 human airway epithelial cells [J]. Journal of Ethnopharmacology, 2008, 117(1): p. 92- 101.
Yu R M, Song L Y, Zhao Y, et al. Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris [J]. Fitoterapia, 2004, 75: 465- 472.
Yu R M, Wang L, Zhang H, et al. Isolation purification and identificationof polysaccharides from cultured Cordyceps militaris [J]. Fitoterapia, 2004, 75: 662- 666.
Yu R M, Yang W, Song L Y, et al. Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris [J]. Carbohydrate Polymers, 2007, 70: 430- 436.
Yu R M, Yin Y, Yang W, et al. Structural elucidation and biological activity of a novel polysaccharide by alkaline extraction from cultured Cordyceps militaris [J]. Carbohydrate Polymers, 2008, 10 (7): 23.
Yu R, et al. Structural elucidation and biological activity of a novel polysaccharide by alkaline extraction from cultured Cordyceps militaris [J]. Carbohydrate Polymers, 2009, 75(1): p. 166- 171.
Yu R, et al. Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris [J]. Carbohydrate Polymers, 2007, 70(4): p. 430- 436.
Zhong M, et al. Effect of selenium-protein polysaccharide extracted from Se-rich Cordyceps militaris on tumor-bearing mice [J]. Zhongguo Zhong Yao Za Zhi, 2008, 33(18): p. 2120- 2123.
陈磊,蛹虫草(Cordyceps militaris)生物学特性及发酵研究[D].中国协和医科大学,2009,58- 59.
白霞,尹莲花,冯艳伟.微波法在蛹虫草多糖提取中的应用[J].大连民族学院学报,2005,(3):96.
宾文,等.人工培养蛹虫草多糖的抗炎及免疫作用研究[J] .时珍国医国药,2003,14(1):1- 2.
蔡仲军,尹定华,秦松云.水提取法测定冬虫夏草中甘露醇的含量[J].重庆教育学报,2002b,15(6):42- 44.
蔡仲军,尹定华,秦松云.不同预处理对冬虫夏草中甘露醇的含量测定的影响[J].广西中医学院学报,2002,5(4):75- 77.
柴建萍,白兴荣,谢道燕.蛹虫草主要有效成分及其药理功效[J].云南农业科技,2003(4):22- 23.
曹丽茹,等.蛹虫草栽培应用研究[J].辽宁林业科技,2006,(2):25,39,F3.
常雅宁,等.两种连苯三酚自氧化法测定超氧化物歧化酶的比较[J].药物分析杂志,2001,(05):328- 331.
陈敬民,李友娣,疗驱等.蛹虫草的镇静催眠作用[J].中药药理与临床,1997,13(6):44- 45.
陈文冬,杨文礼.蛹虫草对运动训练大鼠血清激素水平及运动能力影响的研究[J].西安体育学院学报,2008,(04):86- 89.
崔新颖,崔新羽,张成义.新型蚕蛹虫草对小鼠免疫增强作用的实验研究[J].北华大学学报:自然科学版,2004,5(5)405- 407.
戴瑛,等.蛹虫草提取物对内毒素引起小鼠急性肺损伤的保护作用[J].中国临床药理学与治疗学,2004,9(4):386- 388.
董彩虹.冬虫夏草多糖的研究进展[J].食品科学,2004,25(7)195- 198.
杜鸣,梁芳珍.流动注射-光度法测定超氧阴离子自由基(02-)与超氧化物歧化酶(SOD)活性的研究[J].高等学校化学学报,1999,20(3)369- 373.
冯景刚,刘影.不同培养基配方培养北虫草试验[J].食用菌, 2008,(6):27- 28.
付呜佳.蛹虫草产类胡萝卜素的研究[J].食品与生物技术学报,2005,24(5):107- 110.
韩永萍,林强与何绪文.虫草菌丝体多糖的提取研究[J].食用菌,2007,(6):53- 55.
黄德娟,黄德超.生物活性肽[J].生物学通报,2006,41(4):17- 18.
何次平.蛹虫草米饭栽培工艺要领[J].食用菌,2003,(S1):35- 36.
何洋,等.蛹虫草优化培养研究进展[J].鲁东大学学报(自然科学版),2011,(1):64- 70.
华宁烨,等.富锗蛹虫草无性型乙醇分级多糖抗氧化能力研究[J].徐州工程学院学报(自然科学版),2010(3):61- 66,84.
孔凡海.蛹虫草栽培技术[J].农业知识:瓜果菜,2005,(1):32.
高平.蛹虫草优质高产栽培技术[J].吕梁高等专科学校学报,2007(1):15- 17.
葛新,白小红,李云兰.分光光度计测定蛹虫草D-甘露醇的含量[J].山西医科大学学报,2001,32(4):317- 318.
盖新杰,张伸翼.蛹虫草胞外多糖的研究I半乳甘露聚糖CM-1的纯化和结构研究[J].真菌学报,1992,11(4):300- 307.
古培总,刘飞凤,陈逸湘.蛹虫草高产栽培技术[J].广东农村实用技术,2005,(1):15.
郭晓蕾,等.硫酸蒽酮法与硫酸苯酚法测定灵芝多糖含量比较[J].中华中医药学刊,2010,28(9):2000- 2002.
焦彦朝,梁宗琦,刘爱英,等.虫草生物活性物质研究概况[J].贵州农业科学,1990,(3):53- 58.
江晓路,葛蓓蕾.北虫草菌Y3胞内与胞外多糖的免疫药理研究[J].青岛海洋大学学报,1998,28(2)192- 197.
江晓路,葛蓓蕾,胡晓坷.蛹虫草对药物引起免疫抑制的拮抗作用[J].青岛海洋大学学报,2002,32(l):46- 50.
江晓路,孙月.蛹虫草活性成分的测定[J].食用菌学报,1999,6(01):47- 50.
金凌云,杜双田,马璐,等.蛹虫草栽培基质的模型优化研究[J].西北农林科技大学学报:自然科学版,2009,(11):175- 179.
金凌云,等.蛹虫草栽培基质的模型优化研究[J].西北农林科技大学学报:自然科学版,2009,37(11):175- 179.
金峰.抑瘤多糖-LAK强剂[J].中国肿瘤临床,1996,23(6):433- 436.
金永日.蚕蛹虫草和冬虫夏草中D-甘露醇的分析[J].白求恩医科大学学报,1992,18(1):47- 48.
连云岚,杨中林.北虫草化学成分及药理作用研究进展[J].山西医药杂志,2006,35(1):44- 46.
廖春丽,等.蛹虫草主要有效成分分析[J].安徽农业科学,2008,36(12):5050- 5052.
李春丽,刘晓兰,陈慧鑫,等.蛹虫草深层培养产菌丝体及胞外多糖的初步研究[J].农产品加工(创新版),2010(2):22- 26.
李华为,赵素云,铁梅.富硒蛹虫草抗氧化作用研究[J].食品科学,2010(23):61- 64.
李连德,李增智,樊美珍.虫草多糖研究进展.安徽农业大学学报[J],2000,27(4):413- 416.
李连德,樊美珍,李增智.14种虫草多糖对果蝇成虫寿命影响的实验[J].微生物学通报,2000,27(6)427- 428.
李楠,等.蛹虫草与冬虫夏草化学成分比较[J].吉林农业大学学报,1995,(S1):80- 83.
李雪芹,包天桐,王雁.比色法测定冬虫夏草中甘露醇的含量[J].中草药,1999x,30(1):1921.
李雪芹,熊功有.不同方法测定29种中药甘露醇含量的比较研究[J].九江医学,1999b,14(1):25- 27.
李雪芹,张磊,熊功友.比色法与容量法测定冬虫夏草中甘露醇含量比较研究[J].九江医学,1998,(4):10- 13.
李雪芹,包天桐,王雁.比色法测定冬虫夏草中甘露醇的含量[J].中草药,1999,(1):19- 21.
李信,许雷,裴鑫德.蛹虫草(Cordyceps militaris)菌丝体液体培养基的优化和发酵条件的研究[J].核农学报,1998,(1):36- 41.
李信,许雷.蛹虫草产生的胞外多糖及其理化性能和抗氧化活性的初步研究[J].微生物学杂志,1997,17(3):13- 17.
李信,许雷.蛹虫草菌胞外多糖发酵工艺优化[J].化工冶金,1998,19(3):63- 68.
李欣,等.蛹虫草子实体水提取物对辐射损伤的保护作用研究[J].华南预防医学,2006,32(3)58- 60.
李宗军,温琼英.蛹虫草无性型的研究II.液体发酵培养菌丝体及胞外多糖的提制[J].湖南农业大学学报,1998,(5):38- 42.
梁正岐.蛹虫草月饼及其制作方法:中国,CN1911052[P].2007-02-14.
凌宏通,等.蛹虫草的富硒栽培技术初步研究[J].中国食用菌,2006,25(4)52- 53.
林群英,等.蛹虫草人工栽培条件优化研究[J].中国食用菌,2006,25(6):17- 19.
林庆斌,等.超氧化物歧化酶(SOD)的研究和应用进展[J].化学世界,2006(06):378- 381.
刘春泉,等.北冬虫夏草超微粉对小鼠免疫功能的增强作用[J].江苏农业学报,2007,23(1):63- 66.
刘春泉,等.微波法提取北冬虫夏草中黄酮类化合物.江苏农业学报,2007,23(4):356- 359.
刘红锦,等.蛹虫草多糖提取及纯化工艺研究[J].江西农业学报,2007,19(12):80- 82.
刘刚,国内蛹虫草研究现状.中国中医药信息杂志[J],1994(1):23- 24.
刘建荣,静天玉.超氧化物歧化酶的两种邻苯三酚测活法比较[J].中国生化药物杂志,1996,17(06):234- 237.
刘晓涵,等.蒽酮硫酸法与苯酚硫酸法测定枸杞子中多糖含量的比较[J].食品科技,2009,34(9):270- 272.
刘群.2型糖尿病患者血清超氧化物歧化酶与丙二醛含量的测定及其临床意义[J].河北医药,2001,23(9):66- 67.
刘维兰.食管癌患者血清SOD活性MDA水平变化及其临床意义[J].肿瘤研究与临床,2000,7(5):270- 271.
陆军,滕利荣,程瑛琨,孟庆繁.北虫草多肽纳米系列护肤化妆品及其制备方法:中国,CN1709220[P].2005-12-21.
鲁晓岩.硫酸-苯酚法测定北冬虫夏草多搪含量[J].食品工业科技,2002,23(4):69- 70.
吕子明,等.人工蛹虫草子实体化学成分研究[J].中国中药杂志,2008,34(24):2914- 2917.
孟兆丽,等.蛹虫草多糖抑菌及抗氧化作用研究[J].食品研究与开发,200829(09):31- 33.
马成坚,顾亚萍,芦青.百令胶囊中虫草多糖的提取和含量测定[J].浙江中医学院学报,2004,28(4):81- 82.
孟繁宇.蛹虫草高产菌株人工栽培条件的优化[J].食用菌,2009(4):55-56.
穆忠平.蛹虫草高产栽培技术[J].食用菌,2004,26(5):36.
潘新群,等.蛹虫草菌液体发酵工艺的研究[J].江西农业学报,2006(1):30- 34.
潘新法,蛹虫草子实体的人工培育及超氧化物歧化酶的活性测定[J].食用菌学报,1995,2(03):25- 28.
彭国平,李红阳,袁永泰.冬虫夏草与人工蛹虫草的成分比较[J].南京中医药大学学报,1996,12(5):26- 27.
钱素英.恶性血液病患者血一氧化氮、内皮素及超氧化物歧化酶的变化[J].肿瘤学杂志,2002,7(5):270- 271.
秦秀丽,杨国会,李风林.蛹虫草液体深层发酵的研究[J].北方园艺,2010(23):167- 170.
秦建春,等.蛹虫草发酵液抗菌活性初步研究[J].西北植物学报,2006,26(2):402- 406.
曲友直,赵振伟,高国栋,等.甘露醇对局灶性脑缺血再灌注大鼠脑组织NO及神经细胞凋亡的影响[J].卒中与神经疾病,2004,11(1):812.
阮桂平,彭拓华.冬虫夏草及其类似品中甘露醇的含量研究概况[J].江西中医学院学报, 2001.13(2):96,F3.
施明珠,等.北冬虫夏草对氢化可的松诱导的老龄小鼠肾损伤的保护作用[J].现代药物与临床,2009,24(03):160- 163.
施明珠,等.蛹虫草菌丝体醇提物对氢化可的松致小鼠肝损伤的保护作用[J].中草药,2009,40(02):262- 265.
施英,等.微波辅助提取蚕蛹虫草多糖的研究[J].广东农业科学,2006,(11):41- 42.
锁现民,蔡树威,张现法.浅谈蛹虫草栽培菌种制作及鉴定[J].食用菌,2009,(4):41.
孙成秀,廖纪录,龙小慧,等.甘露醇的临床新用途[J].新医学,1996,27(1):41- 42.
孙悦迎,张旭东.冬虫夏草与蛹虫草特性分析[J].中医药学报,2002,30(02):43- 44.
孙艳,官杰,王琪.人工蛹虫草子实体对荷肝癌小鼠的抑瘤作用及提高NK,IL-2活性的实验研究[J].药物研究,2002,11(7)39- 40.
孙叶,等.蛹虫草规模化人工栽培技术要点[J].江苏农业科学,2008,(6):145- 146.
铁梅,等.蛹虫草富硒栽培特性的研究[J].食用菌,2005,27(4):38- 39.
铁梅,等.硒对蛹虫草生长发育的影响[J].辽宁大学学报(自然科学版),2005(1)25- 27.
万晓星,等.中草药对蛹虫草液体深层发酵的影响[J].大连轻工业学院学报,1998,17(4):6- 11.
王宝贵,张桂英,赵林伊.柞蚕蛹虫草对黑腹果蝇寿命的影响[J].中国老年学杂志,2002,22(3):148-150.
王炳娟,李玲霞,邹洪.邻苯三酚自氧化法测定SOD活性的电化学研究[J].研究报告,2008:(2)29,38.
王化远,唐心.川产野生冬虫夏草不同生长期子座虫体中甘露醇含量比较[J].华西医药杂志,1996b,11(1):58- 59.
王刚,麻兵继,刘吉开.人工蛹虫草化学成分研究[J].中草药,2004,35(5)493- 495.
王琳,王炯,杨继红,尹家元.固相萃取高效液相色普测定冬虫夏草的甘露醇[J].分析实验室,2003,22(6):83- 85.
王菊凤,李鹄鸣.蛹虫草多糖对果蝇寿命影响的研究[J].中国野生植物资源,2008,27(03):38- 41.
王菊凤,杨道德,李鹊呜,等.虫草多糖的研究进展[J].中草药,2006,37(5):6- 8.
王建芳,杨春清.蛹虫草有效成分及药理作用研究进展[J].中医药信息,2005,22(5):30- 32.
王琦.野生蛹虫草与培植蛹虫草清除·OH自由基作用的对比研究[J].辽宁师专学报(自然科学版),2002,(3):43- 45.
王琦,韩晓龙.蛹虫草对老年大鼠自由基代谢影响的研究[J].辽宁师专学报(自然科学版),2002,(4):104- 106.
王琦,韩晓龙,蛹虫草对老年大鼠自由基代谢影响的研究[J].辽宁师专学报,2002,4(2):104- 106.
王雅玲,郑双双,吕国忠,等.我国蛹虫草人工栽培培养基的现状调查[J].食用菌,2009,31(1):1- 2.
王英臣.关于蛹虫草菌多糖发酵及培养基的研究[J].中国酿造,2005(10):29- 31.
王英娟,等.蛹虫草中虫草素、虫草多糖综合提取工艺研究[J].西北植物学报,2005,25(9):1863- 1867.
王栩,刘守华.蛹虫草的代料栽培试验[J].食用菌,2003,25(1):23- 23.
汪宝琪,庞志功.西藏冬虫夏草中D-甘露醇的薄层扫描分析[J].中草药,1995,26(4):189- 190.
武忠伟,等.冬虫夏草和蛹虫草发酵液抗菌活性研究[J].微生物学杂志,2008,28(4):47- 50.
肖代敏,等.药用虫草中甘露醇、多糖的高通量测定及提制工艺[J].食品科学,2010,31(6):11- 15.
薛建娥,冉翠香.蛹虫草人工栽培种的分离与复壮[J].食用菌,2002,24(2):17- 18.
向德军,等.常用真菌类中药清除酶自由基的活力测定[J].药学实践杂志,2000,18(05):286-287.
向会耀,方华舟.不同氮源对蛹虫草菌丝及子实体生长状况的影响[J].湖北农业科学,2010,49(11)2734- 2736.
谢卫华,姚菊芳,袁勤生.连苯三酚自氧化法测定超氧化物歧化酶活性的改进[J].医药工业,1988,19(5):217- 219.
邢振荣,王溶溶,沈雁书,等.冬虫夏草菌体成分分析[J].中成药研究,1986,26(4):189- 191.
徐维蓉,等.人工栽培北冬虫夏草子实体对大鼠下丘脑GnRH细胞mRNA表达的调节作用[J].上海中医药杂志,2009,43(07):72- 74.
徐靖,杨秀岑.邻苯三酚-鲁米诺发光体系测定SOD活性[J].郧阳医学院学报,1999,18(2):68- 69.
许周善,周晓燕.冬虫夏草多搪的研究进展[J].工业微生物,2000,30(1):56- 57.
宣华.不同氮源对北冬虫夏草生长影响的研究[J].佛山科学技术学院学报(自然科学版),2008,26(3):52- 54.
阎家麟,朱建梅,桂兴芬等.牛血铜锌超氧化物歧化酶制备工艺的该进[J].中国医药工业杂志,1992,23(11):481- 483.
闫喜涛,包海鹰,图力古尔.人工培养蛹虫草中一种天然色素的分离和结构鉴定[J].菌物学报,2010(5):777- 781.
杨明琰,等.超氧化物歧化酶两种邻苯三酚自氧化测定活力方法的比较[J].微生物学杂志,2006,26(03):40- 43.
姚倩,孙涛,徐轶霞,等.壳聚糖/壳寡糖衍生物的制备及其抗氧化性能研究[J].食品与生物技术学报,2009,28(2):188- 189.
岳春.蛹虫草保健茶饮料的研制[J].中国酿造,2008,(18):86- 89.
岳春,等.蛹虫草菌保健黄酒的研究[J].酿酒科技,2006,148(10):70- 73.
颜辉,朱冬吉,吴杰.超声波辅助提取蛹虫草多糖的研究[J].江苏农业科学,2009,(1):255- 257.
余丽霞,张冰冰,阮叶萍等.虫草多糖不同组分的免疫活性研究.浙江中医学院学报[J],2004,28(l):49- 50.
袁勤生,王志友,翁清清,等.邻苯三酚自氧化法测定超氧化物歧化酶的活性[J].医药工业杂志,1983,(1):16- 19.
赵丰丽与林严.北冬虫夏草保健酱油的研制[J].中国酿造,2006,162(9):75- 77.
赵丰丽,等.北冬虫夏草保健茶饮料的研制[J].食品工业科技,2007,28(1):132- 134.
赵志君,等.蛹虫草子实体保健酒的研制[J].酿酒,2007,34(06):67- 69.
张博润,田宇清,黄英等.酵母超氧化物歧化酶高产菌选育[J].微生物学报,1994,34(4): 280.
张金艳.蛹虫草人工培养技术及其主要有效成分调控的研究[D].西南大学,2010,67- 70.
张妙霞,等.蒽酮法测定可溶性糖显色条件的研究[J].洛阳农专学报,1997,17(4):24- 28.
张海娟,王文洁,张兵.蚕蛹虫草对巨噬细胞吞噬功能的作用[J].山西职工医学院学报,2008,(04):16- 17.
张海英,比色法测定蒙山九州虫草中甘露醇的含量[J].安徽农业科学,2007,35(27):8523- 8537.
张显科,刘文霞.蛹虫草化学成份测定[J].菌物系统,1997,16(1):78- 80.
张小强,浦跃朴,尹立红,等.冬虫夏草及人工虫草菌丝体对超氧阴离子自由基和轻自由基清除作用的实验研究[J].中国老年学杂志.2003,23(11):773- 775.
张晓燕.超氧化物歧化酶的研究现状及在食品中的应用综述[J].扬州职业大学学报,2002,6(1):90- 95.
张秀娟,等.蛹虫草提取物对H22小鼠抗氧化能力的影响[J].时珍国医国药,2008,19(04):943- 944.
张绪璋.北冬虫夏草的人工培植及其营养成分分析[J].中国食用菌,2002,22(2):19- 21.
赵怡红,吴玲.不同豆类氮源对北冬虫夏草生长影响的研究[J].青海师范大学学报(自然科学版),2009,(2):52- 55.
赵彩云,安冬,张华彬.蛹虫草的栽培技术[J].上海蔬菜,2007,(3):86.
郑婷婷,等.蛹虫草液体培养条件优化及有效成分含量分析[J].菌物研究,2004(4)22- 25.
周广麟,蛹虫草的液体培养(发酵)技术[J].中国食物与营养,2000,(2):26- 27.
邹向英.3种虫草活性成分的对比分析[J].东北农业大学学报,2010,41(7):139- 142.
左志宇,等.蛹虫草菌丝体循环富硒法的建立及其硒多糖抑癌作用初探[J].食用菌, 2008,(03):9- 11.
钟裕容,等.蛹虫草菌丝与冬虫夏草中氨基酸、甘露醇的含量[J].中国中药杂志,1990,(4):39- 40.
朱蕴兰,等.蛹虫草酸奶饮料的研制[J].食品科技, 2008,(10):91- 92.
左克源,等.人工蛹虫草子实体对小鼠免疫功能的影响[J].医药导报,2007,26(3):227- 229.
宋福兴.一种蛹虫草酒及其制备方法:中国,CN200810228178.6[P].2009-04-01.
时闻讯.北虫草营养酒及其酿制方法:中国,CN101363000[P].2009-02-11.
江苏省植物研究所等编著.新华本草纲要[M].上海:上海科学技术出版社,1991:681.
敬一兵,陆鲁生.虫草[M].昆明:云南科技出版社,1986:156.
王国栋.冬虫夏草类:生态、培植、引用[M].北京:科学技术文献出版社,1995:307.
苏哈道尼克.核苷类抗菌素[M].其明,王恕蓉译.北京:科学出版社,1982:476.
邵力平,等编.真菌分类学[M].北京:中国林业出版社,1984:370.
冉先德主编.中华药海[M].北京:哈尔滨出版社,1993:1033- 1872.
徐锦堂.中国药用真菌学[M].北京:北京医科大学及中国协和医科大学联合出版社,1997:394- 400.
中国科学院中国孢子植物志编辑委员会编辑梁宗琦主编.中国真菌志[M].北京:科学出版社,2007:第三十二卷,虫草属.