基于复杂网络技术的慢性心力衰竭证治规律研究
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摘要
目的：探讨慢性心力衰竭证治规律。
方法：采用回顾性调查的方法,搜集3所中医院近5年的1840例慢性心力衰竭住院患者的临床资料,构建证治规律复杂网络图,计算其节点度分布,探讨慢性心力衰竭证治规律。
结果：慢性心力衰竭证候-治法-药物节点度分布符合冥率特征,具备核心结构。其核心治法是补气、温阳、活血、利水、健脾、理气、化痰、疏肝；核心药物是茯苓、白术、桂枝、黄芪、甘草、泽泻、益母草、陈皮、柴胡、郁金、丹参、当归、麦冬、枳壳、半夏、葶苈子、毛冬青；核心药物功效是健脾、补气、利水、疏肝、理气、化痰、活血、温阳、清热、养阴(按关联度由高到低依次排序)。
结论：慢性心力衰竭证治规律具有无尺度网络特征,存在共性的核心结构。根据“以药测证”的理论分析,慢性心力衰竭的核心证候是气阳两虚、血瘀水停；核心治法是益气温阳、活血利水；健脾化痰、疏肝理气法在网络中关联度较高,脾虚痰阻、肝郁气滞是慢性心力衰竭的重要证候,与以往研究不同。复杂网络技术可以为中医学研究疾病提供非预期但很有价值的隐含信息,进而为临床辨证施治提供客观依据。
Objective:To investigate syndrome differentiation and treatment laws of the chronic heart failure.
Methods:Use method of retrospective survey to collect CHF clinical data of three chinese medicine hospital in the past five years, including1840cases of CHF hospitalized patients, and build complex network diagram of syndrome differentiation and treatment laws, calculate the node degree distribution, investigate syndrome differentiation and treatment laws of the chronic heart failure.
Results:CHF syndrome-treatment with drugs node degree distribution-ho rate characteristics, with core structure. The core organizational structure of scale-free networks: the core treatment method is benefiting qi, warming Yang, activating blood circulation, diuresis, invigorating the spleen, regulating qi-flowing, eliminating phlegm, dispersing liver; core drugs:Poria, Atractylodes, Cinnamon Twig, Astragalus, Licorice root, Alisma, Motherwort, Dried tangerine peel, Bupleurum root, Turmeric, Red sage root, Chinese angelica, Radix, Fructus Aurantii, Pinellia tuber, Pepperweed seed, Maodongqing;closely associated syndrome:invigorating spleen, benefiting qi, diuresis, dispersing liver, regulating qi-flowing, eliminating phlegm, activating blood circulation, warming yang, clearing heat, nourishing yin (according to the associated degree in descending order).
Conclusion:CHF card to laws that have a scale-free network characteristics, there are common core structure. According to "to the medicine syndrome" reverse inference model, the core of chronic heart failure syndrome is Yang deficiency of both qi, blood stasis water stop; The temperature Yang, promoting blood circulation:the water is its core treatment; The spleen, eliminating phlegm ShuGan qi in the network correlation degree is higher, spleen, stomach phlegm obstruction and chronic heart failure should be the important syndrome, different from previous research. The complex network technology for traditional chinese medicine research disease can provide the expected but valuable implicit information, and then the pattern identification and treatment for clinical provides an objective basis.
方法：采用回顾性调查的方法,搜集3所中医院近5年的1840例慢性心力衰竭住院患者的临床资料,构建证治规律复杂网络图,计算其节点度分布,探讨慢性心力衰竭证治规律。
结果：慢性心力衰竭证候-治法-药物节点度分布符合冥率特征,具备核心结构。其核心治法是补气、温阳、活血、利水、健脾、理气、化痰、疏肝；核心药物是茯苓、白术、桂枝、黄芪、甘草、泽泻、益母草、陈皮、柴胡、郁金、丹参、当归、麦冬、枳壳、半夏、葶苈子、毛冬青；核心药物功效是健脾、补气、利水、疏肝、理气、化痰、活血、温阳、清热、养阴(按关联度由高到低依次排序)。
结论：慢性心力衰竭证治规律具有无尺度网络特征,存在共性的核心结构。根据“以药测证”的理论分析,慢性心力衰竭的核心证候是气阳两虚、血瘀水停；核心治法是益气温阳、活血利水；健脾化痰、疏肝理气法在网络中关联度较高,脾虚痰阻、肝郁气滞是慢性心力衰竭的重要证候,与以往研究不同。复杂网络技术可以为中医学研究疾病提供非预期但很有价值的隐含信息,进而为临床辨证施治提供客观依据。
Objective:To investigate syndrome differentiation and treatment laws of the chronic heart failure.
Methods:Use method of retrospective survey to collect CHF clinical data of three chinese medicine hospital in the past five years, including1840cases of CHF hospitalized patients, and build complex network diagram of syndrome differentiation and treatment laws, calculate the node degree distribution, investigate syndrome differentiation and treatment laws of the chronic heart failure.
Results:CHF syndrome-treatment with drugs node degree distribution-ho rate characteristics, with core structure. The core organizational structure of scale-free networks: the core treatment method is benefiting qi, warming Yang, activating blood circulation, diuresis, invigorating the spleen, regulating qi-flowing, eliminating phlegm, dispersing liver; core drugs:Poria, Atractylodes, Cinnamon Twig, Astragalus, Licorice root, Alisma, Motherwort, Dried tangerine peel, Bupleurum root, Turmeric, Red sage root, Chinese angelica, Radix, Fructus Aurantii, Pinellia tuber, Pepperweed seed, Maodongqing;closely associated syndrome:invigorating spleen, benefiting qi, diuresis, dispersing liver, regulating qi-flowing, eliminating phlegm, activating blood circulation, warming yang, clearing heat, nourishing yin (according to the associated degree in descending order).
Conclusion:CHF card to laws that have a scale-free network characteristics, there are common core structure. According to "to the medicine syndrome" reverse inference model, the core of chronic heart failure syndrome is Yang deficiency of both qi, blood stasis water stop; The temperature Yang, promoting blood circulation:the water is its core treatment; The spleen, eliminating phlegm ShuGan qi in the network correlation degree is higher, spleen, stomach phlegm obstruction and chronic heart failure should be the important syndrome, different from previous research. The complex network technology for traditional chinese medicine research disease can provide the expected but valuable implicit information, and then the pattern identification and treatment for clinical provides an objective basis.
引文
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