清肺饮加减治疗肺经风热型痤疮的临床研究
|
摘要
目的：对清肺饮加减治疗肺经风热型痤疮的临床研究,综合评价其临床疗效和安全性,并对其作用机制进行初步探讨。
方法：1.按纳入病例的先后顺序将患者随机分配到治疗组(清肺饮加减组)和对照组(丹参酮胶囊组)2.治疗方法：治疗组35例,内服清肺饮加减,药物组成：枇杷叶15g,桑白皮10g,黄芩15g,金银花20g.连翘10g,黄柏15g,知母10g,白花蛇舌草30g,生甘草6g,丹参30g,生地黄20g,牛蒡子10g。1日1剂,分2次服用。对照组33例,内服丹参酮胶囊,1次4粒,1日3次。两组患者合并外用姜黄消痤擦剂,用棉纤取药涂患处,1日2-3次。3.疗程及观察方法：6周为疗程,所有患者2周复诊1次,记录皮损积分及其不良反应。4.疗效评价方法：参考1997年10月中华医学会美学与美容分会皮肤美容学组制定的《寻常痤疮严重程度分级和疗效判定标准》进行疗效观察。根据治疗第2周、第4周、第6周前后皮损数目计数计算疗效指数,并依据综合疗效评价标准评价疗效；根据炎性皮损、非炎性皮损的积分标准进行积分,观察治疗组、对照组对两类皮损的影响。每2周进行一次疗效评价及比较。同时根据与入组时比较,试验过程中患者新出现或加重的症状、体征和疾病,进行安全性评价。
结果：1.清肺饮加减治疗肺经风热型痤疮的显效率14.28%,有效率为57.14%,总有效率为82.86%,丹参酮胶囊组的显效率为5.88%,有效率为58.82,总有效率为70.59%,经X2检验,P<0.05,有显著差异。说明清肺饮加减治疗肺经风热型痤疮的疗效优于对照组。
2.治疗组与对照组综合疗效经卡方检验得出治疗组与对照组治疗2周后,4周后综合疗效相比无显著性差异P>0.05；治疗6周后,两组综合疗效比较有显著性差异P<0.05。
3.治疗组对痤疮患者非炎性皮疹的改善优于对照组,P<0.05,对炎性皮疹的改善与对照组没有显著差异,P>0.05。
4.清肺饮加减治疗组不良反应发生少,说明清肺饮加减治疗肺经风热型痤疮为临床安全方药。
结论：1.清肺饮加减治疗肺经风热型痤疮的疗效确切,用药安全,是治疗痤疮的有效中药复方。2.清肺饮加减对痤疮患者总皮损及非炎性皮损的改善优于对照组。3.清肺饮加减治疗肺经风热型痤疮疗程以不低于6周较为适宜。
The Clinical research of Modified Qing-fei-yin in treatment of Acne about Lung Channel with wind-heat type.
Objective:Generally assess the clinical effect and security of Modified Qing-fei-yin in treatment of Acne about Lung Channel with wind-heat type by clinical study.
Methods:1. Divide the patients who are suffering from acne into two groups randomly.2. The experimental group contains35cases. And the treatment of the experimental group is based on Modified Qing-fei-yin. The ingredients of Modified Qing-fei-yin are:15g loquat, lOg morus,15g scute,20g honeysuckle., lOg forsythia,15g phellodendron, lOg rhizoma anemarrhenae,30g hedyotis,6g wild,30g salvia miltiorrhiza,20g radix rehmanniae recen,10g lappa.one day one pack, twice a day. The control group contains34cases, taking Danshentong Capsules three times a day. The patients taking jiang-huang-xiao-cuo-cha-ji gel twice a day2.3. Period of treatment and observing indicator:The period of treatment is six weeks, take records the number of inflammatory lesions, and take notes of the change of symptoms, adverse reactions every second weeks.4. Clinical criteria testimonial to the effectiveness criteria on "effectiveness criteria and grading standard of acne vulgaris'" establish by Chinese Medical Association dermatology and between the treatment group Oct.1997.
Result:The general effective rate of the treatment group is82.86%and the control group is70.59%; There is a expressive difference between the treatment group and control group of the curative index after6weeks; There is no expressive difference between the treatment group and control group of total skin rash score. The safety indicators Modified Qing-fei-yin in treatment of Acne about Lung Channel with wind-heat type in safe.
Conclusion:1. Modified Qing-fei-yin has good clinical effects and high safety in treatment of Acne about Lung Channel with wind-heat type.2. It can improve Modified Qing-fei-yin in an effiective therapy principle in treatment of Acne about Lung Channel with wind-heat type.3. Modified Qing-fei-yin in treatment of acne about Lung Channel with wind heat type is relatively appropriate for more than six weeks.
方法：1.按纳入病例的先后顺序将患者随机分配到治疗组(清肺饮加减组)和对照组(丹参酮胶囊组)2.治疗方法：治疗组35例,内服清肺饮加减,药物组成：枇杷叶15g,桑白皮10g,黄芩15g,金银花20g.连翘10g,黄柏15g,知母10g,白花蛇舌草30g,生甘草6g,丹参30g,生地黄20g,牛蒡子10g。1日1剂,分2次服用。对照组33例,内服丹参酮胶囊,1次4粒,1日3次。两组患者合并外用姜黄消痤擦剂,用棉纤取药涂患处,1日2-3次。3.疗程及观察方法：6周为疗程,所有患者2周复诊1次,记录皮损积分及其不良反应。4.疗效评价方法：参考1997年10月中华医学会美学与美容分会皮肤美容学组制定的《寻常痤疮严重程度分级和疗效判定标准》进行疗效观察。根据治疗第2周、第4周、第6周前后皮损数目计数计算疗效指数,并依据综合疗效评价标准评价疗效；根据炎性皮损、非炎性皮损的积分标准进行积分,观察治疗组、对照组对两类皮损的影响。每2周进行一次疗效评价及比较。同时根据与入组时比较,试验过程中患者新出现或加重的症状、体征和疾病,进行安全性评价。
结果：1.清肺饮加减治疗肺经风热型痤疮的显效率14.28%,有效率为57.14%,总有效率为82.86%,丹参酮胶囊组的显效率为5.88%,有效率为58.82,总有效率为70.59%,经X2检验,P<0.05,有显著差异。说明清肺饮加减治疗肺经风热型痤疮的疗效优于对照组。
2.治疗组与对照组综合疗效经卡方检验得出治疗组与对照组治疗2周后,4周后综合疗效相比无显著性差异P>0.05；治疗6周后,两组综合疗效比较有显著性差异P<0.05。
3.治疗组对痤疮患者非炎性皮疹的改善优于对照组,P<0.05,对炎性皮疹的改善与对照组没有显著差异,P>0.05。
4.清肺饮加减治疗组不良反应发生少,说明清肺饮加减治疗肺经风热型痤疮为临床安全方药。
结论：1.清肺饮加减治疗肺经风热型痤疮的疗效确切,用药安全,是治疗痤疮的有效中药复方。2.清肺饮加减对痤疮患者总皮损及非炎性皮损的改善优于对照组。3.清肺饮加减治疗肺经风热型痤疮疗程以不低于6周较为适宜。
The Clinical research of Modified Qing-fei-yin in treatment of Acne about Lung Channel with wind-heat type.
Objective:Generally assess the clinical effect and security of Modified Qing-fei-yin in treatment of Acne about Lung Channel with wind-heat type by clinical study.
Methods:1. Divide the patients who are suffering from acne into two groups randomly.2. The experimental group contains35cases. And the treatment of the experimental group is based on Modified Qing-fei-yin. The ingredients of Modified Qing-fei-yin are:15g loquat, lOg morus,15g scute,20g honeysuckle., lOg forsythia,15g phellodendron, lOg rhizoma anemarrhenae,30g hedyotis,6g wild,30g salvia miltiorrhiza,20g radix rehmanniae recen,10g lappa.one day one pack, twice a day. The control group contains34cases, taking Danshentong Capsules three times a day. The patients taking jiang-huang-xiao-cuo-cha-ji gel twice a day2.3. Period of treatment and observing indicator:The period of treatment is six weeks, take records the number of inflammatory lesions, and take notes of the change of symptoms, adverse reactions every second weeks.4. Clinical criteria testimonial to the effectiveness criteria on "effectiveness criteria and grading standard of acne vulgaris'" establish by Chinese Medical Association dermatology and between the treatment group Oct.1997.
Result:The general effective rate of the treatment group is82.86%and the control group is70.59%; There is a expressive difference between the treatment group and control group of the curative index after6weeks; There is no expressive difference between the treatment group and control group of total skin rash score. The safety indicators Modified Qing-fei-yin in treatment of Acne about Lung Channel with wind-heat type in safe.
Conclusion:1. Modified Qing-fei-yin has good clinical effects and high safety in treatment of Acne about Lung Channel with wind-heat type.2. It can improve Modified Qing-fei-yin in an effiective therapy principle in treatment of Acne about Lung Channel with wind-heat type.3. Modified Qing-fei-yin in treatment of acne about Lung Channel with wind heat type is relatively appropriate for more than six weeks.
引文
[1]赵炳南,张志礼.简明中医皮肤病学.北京：中国展望出版社,1983.238.
[2]张志礼.皮肤科手册.北京：中医古籍出版社,2004.4722473.
[3]中国中医研究院广安门医院.朱仁康临床经验集.北京：人民卫生出版社,1986.197.
[4]徐爱琴.徐宜厚诊疗痤疮经验.中医杂志,1998,39(2)：80.
[5]华华.薛伯寿教授治疗痤疮的中医辨证体会.中医药学报,2005,33(6)：37.
[6]阙华发.陆德铭治痤疮经验撷萃.江西中医药,1997,29(3)：7.
[7]周德瑛,李映琳.金起凤老中医清热凉血法治疗皮肤病经验举隅.中医教育,1994,(2)：36
[8]禤国维.皮肤病临证见解.新中医,1996,28(1)：14
[9]陈信生.范瑞强教授治疗痤疮经验.新中医,2001,33(9)：71
[10]扈晓成.辨证治疗寻常型痤疮86例临床观察[J].河北中医,2005,27(8)：584
[11]杨健芳.148例痤疮中医辨证分型与临床疗效观察[J].湖南医科大学学报,2001,26(3)：220
[12]王朝霞,李金祥.中医辨证治疗痤疮115例[J].河南中医药学刊,2000,15(2)：27-28
[13]齐凤琴,韩淑香,富学东等.五参散治疗寻常性痤疮156例临床研究[J].时珍国医国药,2005,16(5)：409
[14]李灵巧.排毒消痤饮治疗寻常性痤疮135例[J].河北中医药学报,2002,17(2)：9-10
[15]孔瑞龙.清热解毒合剂治疗痤疮的临床观察[J].辽宁中医杂志,2004,31(5)：431
[16]傅佩骏,马绍.枇杷清肺饮加减治疗痤疮疗效观察[J].辽宁中医杂志,2005,32(7)：679-680
[17]许新.普济消毒饮加味治疗面部痤疮50例[J].河南中医学院学报,2005,20(119)：7
[18]王渝,崔丽.消痤汤治疗寻常型痤疮166例临床观察[J].河北中医,2004,26(6)：426
[19]石乃玉,董华民.丹参酮药理及临床应用[J].中国医师杂志,2001,3：150-151.
[20]宋韬,盛晚香,孙祥银等.丹参酮治疗寻常性痤疮及对皮脂分泌的影响[J].中国麻风皮肤病杂志,2006,22(9)：793.
[21]祁少海,谢举临,利天增.积雪甙对烧伤增生性疤痕作用的实验研究[J].中国现代医学杂志,1999,9(9)：113-115.
[22]谢举临,利天增,祁少海.积雪甙对体外培养的成纤维细胞的生物学作用的实验研究[J].中国现代医学杂志,1999,9(9)：119-126.
[23]王玮蓁,曾宪玉,段逸群.积雪苷片治疗伴有结节损害的寻常痤疮[J].世界临床药物.2003,24：(479-481).
[24]胡东流,范瑞强.一清颗粒治疗寻常痤疮62例分析[J].实用中医内科学杂志,2003,17(4)：324.
[25]冯国强,李咏梅.一清胶囊治疗328例痤疮的临床观察[J].华西药学杂志,2001,1,38.
[26]苏丽.中药外洗治疗痤疮[J].中医外治杂志,2000,9(2)：1
[27]张傲清,黄丽珍.中药熏洗配面膜治疗痤疮[J].中国医学美容杂志,1995,4(1)：101
[28]李玉。中西结合治疗寻常型痤疮50例[J].中国民间疗法,2005,13(9)：5-6
[29]蒋志洪,甘宁峰 中药外治寻常性痤疮48例[J].广西中医药,2003,26(5)：15
[30]范正泰,施振华,刘屹球.中药倒膜治疗痤疮.中国医学美学美容杂志,2005,4(1)：51
[31]彭晓云,彭建梅,李高兴。中药倒膜联合外搽治疗的疗效观察[J].中华医学美学美容杂志,2006,12(4)：198
[32]刘毅,崔艳花。中西医结合治疗重度痤疮的临床观察[J].中国麻风皮肤病杂志,2005,21(3)：237
[33]王恩 林莺,杨毅。痤疮膏外治痤疮54例疗效观察[J],长春中医药大学学报,2010,26(2)：244-245
[34]张华.8701搽剂治疗痤疮144例[J].湖南中医杂志,2000,(1)：50
[35]颜德宽.开颜露为主治疗痤疮608例[J].新中医,2005,(5)：46
[36]乔嘉斌,孙勇强.针刺治疗寻常性痤疮[J].山东中医杂志,2004,23(10)：608
[37]慈勤仁,解乐清,仲春光.针刺配合点刺放血治疗痤疮89例[J].中医外治杂志,2005,14(4)：37
[38]冀健民,赵琦.耳穴贴压治疗寻常痤疮118例临床观察[J].天津中医,2001,18(6)：15
[39]侯慧先,吴童.耳穴埋针治疗颜面痤疮56例[J].针灸临床杂志,2001,17(11)：10
[40]周学志,孙风艳.中医蜂疗治痤疮32例临床观察[J].黑龙江中医药,2001,(2)：57
[41]丁原全,董瑞祥,张信.火针治疗痤疮50例[J].中国针灸,2000,20(2)：84
[42]林宏.刮痧放血法治疗痤疮临床观察[J].中国医药学,2000,15(1)：75
[1]JArnolJrHL, OdomRB, JamesWD. Andrews Diseaseoftheskin8thed. Philadelphia: Saunders,1990.1250-253.
[2]于小兵,吴晓金,桑旭东等.对痤疮患者生活质量影响因素的分析.中国麻风皮肤病杂志2006；10：816-818.
[3]Newton JN, MallonE, KlassenA, et al. The effectiveness of acnetreatment:an assessment bypatients of the outcome of therapy. BrJ Dermatol 1997; 137:563-567.
[4]White GM. Recent findings in the epidemiologic evidence, classification, and subtypes ofacne. J Am Acad Dermatol 1998; 39:34-37
[5]KilkennyM, MerlinK, PlunkettA, etal. The prevalence of common skin conditions in Australians school students:3. Acnevulgaris. BrJDermatol 1998; 139:840-845.
[6]《临床皮肤病学》,第3版,江苏科技出版社.
[7]Goulden V, Clark SM, Cunliffe WJ. Post-adolescent acne:a review of clinical feature. Br J Dermatol 1997; 136:66-70
[8]Goulden V, Stables GI. Prevalence of facial acne in adults. J Am Acad Dermatol 1999; 41:577-580
[9]Goulden V, Stables GI. The prevalence of facial acne in adults. Br J Dermatol 1997; 137:40
[10]王侠生,廖康煌。杨国亮皮肤病学[M]。上海：上海科学技术文献出版社,2005,725,728
[11]Harald Gollnick MD, Willian Cunliffe MD, FRCP, Management of acne:A report from a global alliance to improve outcomes inacne[J]. J Am Acad Dermatol,2003,49:s2-5
[12]姜春明,葛蒙梁.痤疮发病机制研究进展[J].皮肤病与性病,203,25(1)：16-18
[13]曾燕.痤疮患者外周血白细胞雄激素受体的测定[J].中华皮肤科杂志,1999,32(4)：131
[14]弓娟琴,故兹嘉.痤疮与雄激素关系的研究进展[J].国外医学皮肤性病学分册,1997,23(1)：65
[15]鞠强,石继海,夏隆庆.白介素—1与痤疮[J].国外医学·皮肤性病学分册,2001,27：24-26.
[16]Anniehiu, BS;SusanY. skin disease to stress[J]. Arch Dermatol,2003,193:897-900
[17]Masaaki,Morohashi,New aspects in flammation[J]. Dermatology,2003,206:17223
[18]陈昭,王建美,高顺强.痤疮病因研究进展.中国煤炭工业医学杂志,2005,8(2)：107
[19]A.Koreck, A.Pivarcsi, A.Dobozy, The Role of innateimmunity in the pathogenesis of acne[J]. Dermatology,2003,206:96105
[20]JamesJ.Leyden.MD Areviewof the use of combination for the treatment of acne vulgaris[J]. AM. AcadDermatol,2003,9; S 200201
[21]李仪方,鞠强,黄劲盘.对725例皮肤病患者发锌铜值及其意义[J].微量元素与健康研究,1998,15(4)：27-28.
[22]何莉萍,郝俊,于开封.张瑞斌痤疮患者血清锌水平及加锌治疗效果[J].广东微量元素科学,2001,8(4)：46-48.
[23]Fitipatrical TB, etal. Dermatology Ingeneral[M],1985,96:26.
[24]吴伊旋,胡煜文,王晨梁.寻常痤疮患者临床调查分析.上海第二医科大学学报,2004,24(5)：411
[25]王大光综述,朱文元审校.痤疮发病中毛囊皮脂腺导管异常角化的机制.中国麻风皮肤病杂志,2005,21(1)：37
[26]杨智,何黎.痤疮与遗传.国外医学皮肤性病学分册,2005,31(1)：33-34
[27]SchaferT,NienhausA,VielufD,etal.Epidemiology of acne in the general population:therisk of smoking. BrJDermatol,2001,145:100-104
[28]KoulianosGT.Treatment of acne with oral contraceptives crite for pill selection[J]. Cutis2000; 66(4):281
[29]Sawaya ME. Clinical update in hair[J]. Dematol Clin 1997: 15(1):37
[30]Wiegratz. Managing cutaneous an infestations of hyperand rogenic disorders the role of oral contraceptives[J]. Treat Endocrinio; 2002; (16):372
[31]Yemisci A. Effects and side-effects of spirono lactone therapy in women with acne[J]. Eur Acad Dermatol Venereol 2005; 19(2):163
[32]徐叔云.临床用药指南[M].合肥：安徽科学技术出版社,1991：604-606.
[33]刘峥,黄新发.痤疮药物外治的临床应用进展[J].人民军医杂志1996；426(1)：43
[34]梁勇才.实用皮肤诊疗全书[M].北京：学苑出版社出版,1996：971
[35]金诗怡,郑捷.维A酸类药物在皮肤科的应用[J].中国麻风皮肤病杂志.2003：19(2)：149
[36]Mandekou L DelliF. Low-dose schema of isotretinoin in acne[J]. Int JClin Pham2003; 23(2):341
[37]雷霞,鲁元刚,赵莉蓉,等.口服维胺酯胶囊治疗寻常痤疮[J].中华皮肤科杂志,2003；36(2)：114
[38]Waugh J Noble S Scott, a review of its use in the treatment of acne [J]. Drugs2004; 64(13):1465
[39]张石革,马国辉.痤疮的药物治疗中的若干问题[J].中国全科医学,2004；(10)：734
[40]NishijimS, The bacteriology of acne and anti microbial susceptibility of Propionibacterium acnes and Staphy lococcu epidemid is isolated from acne lesions[J]. Demato12000; (5):318
[41]尹兴平,夏隆庆.痤疮患者痤疮丙酸杆菌耐药性的研究进展[J].国外医学皮肤性病学分册,2004：30(3)：152
[42]Thiboutot DM. Acne Rosacea New and emerging therapies[J]. Dermatol Clin2000; 18(1):63
[43]ThiboutotD. New treatment and therapeutic strategies for acne[J]. Arch FamMed,2000; 9(2):179
[44]TaybrGA, Shalita AR. Benzoyl peroxide-based combination therapies for acne[J]. Am JClin Dematol,2004; 5(4):261
[45]靳培英.痤疮的分型论治[J].中华皮肤科杂志.2002,35(2)：162-165.
[46]秦万章.痤疮的中西医结合治疗研究[R].2003年中西医结合皮肤科会议摘要.
[47]Elman M. The role of pulsed light and heat energy in acne clearance[J]. Cosmet Laser Ther,2004,6(2):91-95
[48]朱文元.痤疮[M].南京：东南大学出版社,278-303.
[1]王裕生.中药药理与应用[M].北京：人民卫生出版社,1996.
[2]王本祥.现代中药药理与临床[M].天津科技翻译出版公司,2004.6
[3]周华。寻常痤疮和免疫[J].国外医学·皮肤性病学分册,1990：14-17
[4]吴杲,何招兵,吴汉武。丹参酮的药理作用研究进展[J].现代中医西结合杂志,2005,14(10)：1384-1385
[5]夏丽英.现代中药毒理学[M].天津：天津科技翻译出版社,2005,10.
[2]张志礼.皮肤科手册.北京：中医古籍出版社,2004.4722473.
[3]中国中医研究院广安门医院.朱仁康临床经验集.北京：人民卫生出版社,1986.197.
[4]徐爱琴.徐宜厚诊疗痤疮经验.中医杂志,1998,39(2)：80.
[5]华华.薛伯寿教授治疗痤疮的中医辨证体会.中医药学报,2005,33(6)：37.
[6]阙华发.陆德铭治痤疮经验撷萃.江西中医药,1997,29(3)：7.
[7]周德瑛,李映琳.金起凤老中医清热凉血法治疗皮肤病经验举隅.中医教育,1994,(2)：36
[8]禤国维.皮肤病临证见解.新中医,1996,28(1)：14
[9]陈信生.范瑞强教授治疗痤疮经验.新中医,2001,33(9)：71
[10]扈晓成.辨证治疗寻常型痤疮86例临床观察[J].河北中医,2005,27(8)：584
[11]杨健芳.148例痤疮中医辨证分型与临床疗效观察[J].湖南医科大学学报,2001,26(3)：220
[12]王朝霞,李金祥.中医辨证治疗痤疮115例[J].河南中医药学刊,2000,15(2)：27-28
[13]齐凤琴,韩淑香,富学东等.五参散治疗寻常性痤疮156例临床研究[J].时珍国医国药,2005,16(5)：409
[14]李灵巧.排毒消痤饮治疗寻常性痤疮135例[J].河北中医药学报,2002,17(2)：9-10
[15]孔瑞龙.清热解毒合剂治疗痤疮的临床观察[J].辽宁中医杂志,2004,31(5)：431
[16]傅佩骏,马绍.枇杷清肺饮加减治疗痤疮疗效观察[J].辽宁中医杂志,2005,32(7)：679-680
[17]许新.普济消毒饮加味治疗面部痤疮50例[J].河南中医学院学报,2005,20(119)：7
[18]王渝,崔丽.消痤汤治疗寻常型痤疮166例临床观察[J].河北中医,2004,26(6)：426
[19]石乃玉,董华民.丹参酮药理及临床应用[J].中国医师杂志,2001,3：150-151.
[20]宋韬,盛晚香,孙祥银等.丹参酮治疗寻常性痤疮及对皮脂分泌的影响[J].中国麻风皮肤病杂志,2006,22(9)：793.
[21]祁少海,谢举临,利天增.积雪甙对烧伤增生性疤痕作用的实验研究[J].中国现代医学杂志,1999,9(9)：113-115.
[22]谢举临,利天增,祁少海.积雪甙对体外培养的成纤维细胞的生物学作用的实验研究[J].中国现代医学杂志,1999,9(9)：119-126.
[23]王玮蓁,曾宪玉,段逸群.积雪苷片治疗伴有结节损害的寻常痤疮[J].世界临床药物.2003,24：(479-481).
[24]胡东流,范瑞强.一清颗粒治疗寻常痤疮62例分析[J].实用中医内科学杂志,2003,17(4)：324.
[25]冯国强,李咏梅.一清胶囊治疗328例痤疮的临床观察[J].华西药学杂志,2001,1,38.
[26]苏丽.中药外洗治疗痤疮[J].中医外治杂志,2000,9(2)：1
[27]张傲清,黄丽珍.中药熏洗配面膜治疗痤疮[J].中国医学美容杂志,1995,4(1)：101
[28]李玉。中西结合治疗寻常型痤疮50例[J].中国民间疗法,2005,13(9)：5-6
[29]蒋志洪,甘宁峰 中药外治寻常性痤疮48例[J].广西中医药,2003,26(5)：15
[30]范正泰,施振华,刘屹球.中药倒膜治疗痤疮.中国医学美学美容杂志,2005,4(1)：51
[31]彭晓云,彭建梅,李高兴。中药倒膜联合外搽治疗的疗效观察[J].中华医学美学美容杂志,2006,12(4)：198
[32]刘毅,崔艳花。中西医结合治疗重度痤疮的临床观察[J].中国麻风皮肤病杂志,2005,21(3)：237
[33]王恩 林莺,杨毅。痤疮膏外治痤疮54例疗效观察[J],长春中医药大学学报,2010,26(2)：244-245
[34]张华.8701搽剂治疗痤疮144例[J].湖南中医杂志,2000,(1)：50
[35]颜德宽.开颜露为主治疗痤疮608例[J].新中医,2005,(5)：46
[36]乔嘉斌,孙勇强.针刺治疗寻常性痤疮[J].山东中医杂志,2004,23(10)：608
[37]慈勤仁,解乐清,仲春光.针刺配合点刺放血治疗痤疮89例[J].中医外治杂志,2005,14(4)：37
[38]冀健民,赵琦.耳穴贴压治疗寻常痤疮118例临床观察[J].天津中医,2001,18(6)：15
[39]侯慧先,吴童.耳穴埋针治疗颜面痤疮56例[J].针灸临床杂志,2001,17(11)：10
[40]周学志,孙风艳.中医蜂疗治痤疮32例临床观察[J].黑龙江中医药,2001,(2)：57
[41]丁原全,董瑞祥,张信.火针治疗痤疮50例[J].中国针灸,2000,20(2)：84
[42]林宏.刮痧放血法治疗痤疮临床观察[J].中国医药学,2000,15(1)：75
[1]JArnolJrHL, OdomRB, JamesWD. Andrews Diseaseoftheskin8thed. Philadelphia: Saunders,1990.1250-253.
[2]于小兵,吴晓金,桑旭东等.对痤疮患者生活质量影响因素的分析.中国麻风皮肤病杂志2006；10：816-818.
[3]Newton JN, MallonE, KlassenA, et al. The effectiveness of acnetreatment:an assessment bypatients of the outcome of therapy. BrJ Dermatol 1997; 137:563-567.
[4]White GM. Recent findings in the epidemiologic evidence, classification, and subtypes ofacne. J Am Acad Dermatol 1998; 39:34-37
[5]KilkennyM, MerlinK, PlunkettA, etal. The prevalence of common skin conditions in Australians school students:3. Acnevulgaris. BrJDermatol 1998; 139:840-845.
[6]《临床皮肤病学》,第3版,江苏科技出版社.
[7]Goulden V, Clark SM, Cunliffe WJ. Post-adolescent acne:a review of clinical feature. Br J Dermatol 1997; 136:66-70
[8]Goulden V, Stables GI. Prevalence of facial acne in adults. J Am Acad Dermatol 1999; 41:577-580
[9]Goulden V, Stables GI. The prevalence of facial acne in adults. Br J Dermatol 1997; 137:40
[10]王侠生,廖康煌。杨国亮皮肤病学[M]。上海：上海科学技术文献出版社,2005,725,728
[11]Harald Gollnick MD, Willian Cunliffe MD, FRCP, Management of acne:A report from a global alliance to improve outcomes inacne[J]. J Am Acad Dermatol,2003,49:s2-5
[12]姜春明,葛蒙梁.痤疮发病机制研究进展[J].皮肤病与性病,203,25(1)：16-18
[13]曾燕.痤疮患者外周血白细胞雄激素受体的测定[J].中华皮肤科杂志,1999,32(4)：131
[14]弓娟琴,故兹嘉.痤疮与雄激素关系的研究进展[J].国外医学皮肤性病学分册,1997,23(1)：65
[15]鞠强,石继海,夏隆庆.白介素—1与痤疮[J].国外医学·皮肤性病学分册,2001,27：24-26.
[16]Anniehiu, BS;SusanY. skin disease to stress[J]. Arch Dermatol,2003,193:897-900
[17]Masaaki,Morohashi,New aspects in flammation[J]. Dermatology,2003,206:17223
[18]陈昭,王建美,高顺强.痤疮病因研究进展.中国煤炭工业医学杂志,2005,8(2)：107
[19]A.Koreck, A.Pivarcsi, A.Dobozy, The Role of innateimmunity in the pathogenesis of acne[J]. Dermatology,2003,206:96105
[20]JamesJ.Leyden.MD Areviewof the use of combination for the treatment of acne vulgaris[J]. AM. AcadDermatol,2003,9; S 200201
[21]李仪方,鞠强,黄劲盘.对725例皮肤病患者发锌铜值及其意义[J].微量元素与健康研究,1998,15(4)：27-28.
[22]何莉萍,郝俊,于开封.张瑞斌痤疮患者血清锌水平及加锌治疗效果[J].广东微量元素科学,2001,8(4)：46-48.
[23]Fitipatrical TB, etal. Dermatology Ingeneral[M],1985,96:26.
[24]吴伊旋,胡煜文,王晨梁.寻常痤疮患者临床调查分析.上海第二医科大学学报,2004,24(5)：411
[25]王大光综述,朱文元审校.痤疮发病中毛囊皮脂腺导管异常角化的机制.中国麻风皮肤病杂志,2005,21(1)：37
[26]杨智,何黎.痤疮与遗传.国外医学皮肤性病学分册,2005,31(1)：33-34
[27]SchaferT,NienhausA,VielufD,etal.Epidemiology of acne in the general population:therisk of smoking. BrJDermatol,2001,145:100-104
[28]KoulianosGT.Treatment of acne with oral contraceptives crite for pill selection[J]. Cutis2000; 66(4):281
[29]Sawaya ME. Clinical update in hair[J]. Dematol Clin 1997: 15(1):37
[30]Wiegratz. Managing cutaneous an infestations of hyperand rogenic disorders the role of oral contraceptives[J]. Treat Endocrinio; 2002; (16):372
[31]Yemisci A. Effects and side-effects of spirono lactone therapy in women with acne[J]. Eur Acad Dermatol Venereol 2005; 19(2):163
[32]徐叔云.临床用药指南[M].合肥：安徽科学技术出版社,1991：604-606.
[33]刘峥,黄新发.痤疮药物外治的临床应用进展[J].人民军医杂志1996；426(1)：43
[34]梁勇才.实用皮肤诊疗全书[M].北京：学苑出版社出版,1996：971
[35]金诗怡,郑捷.维A酸类药物在皮肤科的应用[J].中国麻风皮肤病杂志.2003：19(2)：149
[36]Mandekou L DelliF. Low-dose schema of isotretinoin in acne[J]. Int JClin Pham2003; 23(2):341
[37]雷霞,鲁元刚,赵莉蓉,等.口服维胺酯胶囊治疗寻常痤疮[J].中华皮肤科杂志,2003；36(2)：114
[38]Waugh J Noble S Scott, a review of its use in the treatment of acne [J]. Drugs2004; 64(13):1465
[39]张石革,马国辉.痤疮的药物治疗中的若干问题[J].中国全科医学,2004；(10)：734
[40]NishijimS, The bacteriology of acne and anti microbial susceptibility of Propionibacterium acnes and Staphy lococcu epidemid is isolated from acne lesions[J]. Demato12000; (5):318
[41]尹兴平,夏隆庆.痤疮患者痤疮丙酸杆菌耐药性的研究进展[J].国外医学皮肤性病学分册,2004：30(3)：152
[42]Thiboutot DM. Acne Rosacea New and emerging therapies[J]. Dermatol Clin2000; 18(1):63
[43]ThiboutotD. New treatment and therapeutic strategies for acne[J]. Arch FamMed,2000; 9(2):179
[44]TaybrGA, Shalita AR. Benzoyl peroxide-based combination therapies for acne[J]. Am JClin Dematol,2004; 5(4):261
[45]靳培英.痤疮的分型论治[J].中华皮肤科杂志.2002,35(2)：162-165.
[46]秦万章.痤疮的中西医结合治疗研究[R].2003年中西医结合皮肤科会议摘要.
[47]Elman M. The role of pulsed light and heat energy in acne clearance[J]. Cosmet Laser Ther,2004,6(2):91-95
[48]朱文元.痤疮[M].南京：东南大学出版社,278-303.
[1]王裕生.中药药理与应用[M].北京：人民卫生出版社,1996.
[2]王本祥.现代中药药理与临床[M].天津科技翻译出版公司,2004.6
[3]周华。寻常痤疮和免疫[J].国外医学·皮肤性病学分册,1990：14-17
[4]吴杲,何招兵,吴汉武。丹参酮的药理作用研究进展[J].现代中医西结合杂志,2005,14(10)：1384-1385
[5]夏丽英.现代中药毒理学[M].天津：天津科技翻译出版社,2005,10.