藿朴夏苓汤加减治疗慢性浅表性胃炎（脾胃湿热证）的临床研究
|
摘要
目的
本研究旨在从临床方面观察藿朴夏苓汤加减治疗慢性浅表性胃炎(脾胃湿热证)的疗效并探讨其可能的作用机理,为临床新药研究提供理论依据。
方法
选取湖北省中医院消化内科门诊就诊及住院病人100份(经胃镜及病理检查后确诊为慢性浅表性胃炎,中医辨证为脾胃湿热证),随机将其分为治疗组(中西药结合组)及对照组(单纯西药组)各50例。两组患者在治疗前性别、年龄、病程、主要中医症候、中医症候积分、胃镜检查情况、病理检查情况、幽门螺杆菌(HP)感染情况方面的比较均无显著性差异(P＞0.05),具有可比性。
对照组给予单纯西药治疗,治疗组在同种西药的基础上再给予藿朴夏苓汤加减方治疗。两组病例中有反酸者给予奥美拉唑肠溶胶囊(奥克,口服,20mg/次,2次/日)抑酸,有胃排空障碍及十二指肠液反流者给予吗丁啉片(口服,10mg/次,3次/日)促胃动力,有胃黏膜充血、糜烂严重者给予硫糖铝混悬液(舒可捷,口服,5ml/次,3次/日)保护胃粘膜,HP阳性病例同时给予克拉霉素缓释片(康婷,口服,250mg/次,2次/日),阿莫西林胶囊(抗之霸,口服,1.0g/次,2次/日)等药物治疗。治疗组同时给予藿朴夏苓汤加减(由藿香15g、厚朴10g、半夏10g、赤茯苓10g、白蔻仁6g、陈皮10g、玄胡10g、黄连6g、苍术15g、白术10g、蒲公英20g、炙甘草6g等组成)治疗,水煎温服日一剂,一剂分两次服用,200ml/次。
两组病例均以四周为一疗程,服药一疗程后进行疗效判定。观察两组患者治疗后临床总疗效、主要中医症候及积分改善情况、胃镜检查情况、病理检查情况及Hp阴转情况。
结果
治疗后治疗组临床总疗效为92.0%,对照组为78.0%,经统计学分析,P＜0.05,具有显著性差异;治疗组在中医症候疗效的总有效率为96.0%,对照组为78.0%,经统计学分析P＜0.05,具有显著性差异;治疗组中医症候积分、中医主、次症积分改善方面均优于对照组(P＜0.05);治疗组在胃镜像、病理变化方面的有效率分别为:76.0%、82.0%,对照组分别为:58.0%、62.0%,治疗组在这两方面的改善均优于对照组(P＜0.05);但治疗组HP阴转率为45.4%,对照组为25.8%,组间比较经统计学分析,P＞0.05,两组对Hp感染情况改善方面没有明显差异。
结论
本研究在清热燥湿、健脾益胃、理气止痛治则基础上,结合现代医学Hp感染、胃肠功能失调、胃粘膜防御机制失常等理论,选药组方藿朴夏苓汤加减结合常规西药治疗该疾病,结果显示:中西药结合治疗慢性浅表性胃炎(脾胃湿热证)有良好的临床疗效,其效果优于单纯西药组。从现代医药理论观察藿朴夏苓汤加减方可能具有抗炎止痛、提高机体免疫力、保护胃粘膜、促胃肠运动、抗Hp感染、抗肿瘤等作用,结合相关西药治疗该病时,具有协同增强的效果。说明藿朴夏苓汤加减方的组方切合临床实际,在治疗慢性浅表性胃炎(脾胃湿热证)方面确有一定疗效,值得进一步研究及推广。
OBJIECT
This thesis aims to provide theoretical basis for the study of the new clinical medicine by observing the curative effects of the Addition and Subtraction Treatment of chronic superficial gastritis (CSG) by decoction HUO PU XIA LING TANG and discussing its possible functional mechanism.
METHODS
100 patients whose diseases are diagnosed as CSG (damp-heat in spleen and stomach) after gastroscopic and pathological examinations in the digestive medical department of Hubei Traditional Chinese Medical Hospital are selected as subjects and randomly divided into two equal groups: the treatment group of CCTWM and the control group of simple western medicine. The two groups of patients are comparable since they have no significant differences before treatments in aspects of sex, age, course of disease, main traditional Chinese medical symptom, gastroscopic examination, pathological test, and Hp infection (P>0. 05 )..
In the two groups, those who show acrid regurgitation are treated by omeprazole enteric-coated tablets (swallow, 20mg every time and twice a day) . Those who have acid suppression, delayed gastric emptying and duodenal reflux are treated by Motilium tablets to promote gastric dynamics (swallow, 10mg every time and three times a day ) . Those who have hyperemia gastric mucosa and severe erosion are treated by sucralfate suspension to protect gastric mucosa (Sucralfate, swallow, 5ml every time and three times a day) . Those with severe erosion of gastric mucosa in the control group are treated by omeprazole enteric-coated tablets (swallow, 20mg every time and twice a day), clarithromycin tablets (swallow, 250mg every time and twice a day) and amoxicillin tablets (swallow, 1.0g every time and twice a day ). The treatment group is treated with decoction HUO PU XIA LING TANG, the composition of which includes agastache rugosa, magnolia officianlis, pinellia ternate, poria cocos, Amoni compacti, coix seed, almond, coptis chinensis, atractylodes lancea, atractylodes, eupatorium fortune and taraxacum herb. Take these herbal decoctions with luke warm water, 200ml every time and twice a day.
One treatment period is 4 weeks for each groups. The curative effects will be judged after the patients have taken the medicine for one period. What need observing include the total effective rate of patients in the two groups, main CTM symptoms and the improvements of the integrals and the results of gastroscopic and pathological examinations and Hp negative-conversion.
RESULTS
After the treatment, the total curative effect of the treatment group is 92.0% and the control group 78.0%. The statistic analysis reveals that when P<0. 05, it has significant differences. The total effective rate of the treament group in the Chinese medical symptom is 96. 0% and the control group 78.0%. Statistics reveals that when P< 0. 05, it has significant differences. Traditional Chinese medicine syndrome integrals of the treatment group and the improvement of the main and minor syndrome integrals are better than that of the control group ( P < 0. 05 ) . The effective rate of the treatment group in gastroscopic examinations and pathological changes are 76.0% and 82.0% respectively while the control group 58.0% and 62.0%. The improvement of the treatment group is obviously better than that of the control group (P<0. 05 ) , but the rate of Hp negative-conversion is 45.4% while the control group 25.8%. The statistic analysis shows that when P > 0. 05, the two groups have no significant differences in avoiding Hp infection.
CONCLUSION
Based on the traditional methods of heat-clearing and damp-drying, invigorating spleen and stomach and regulating Qi and analgesia with a combination of the theories of modern medical science such as Hp inflection, gastrointestinal dysfunction and maladjustment of the mechanisms of gastric mucosal protection, this thesis decoction HUO PU XIA LING TANG usually uses western medicine to treat the disease. The result reveals that CCTWM is very effective in treating CSG, and the effect is better than that of the control group which uses western medicine only. decoction HUO PU XIA LING TANG possibly have such functions as antiinflammation and analgesia, increase body's immunity, protect gastric mucosa, enhance gastrointestinal impetus, anti Hp infection and antitumor. In treating the disease with western medicine, it has a synergetic enchanting effect. It shows that the composing prescriptions of decoction HUO PU XIA LING TANG is suitable for the clinical reality. They do have some curative effects in treating CSG (damp-heat in spleen and stomach)and are worth further study and recommending.
本研究旨在从临床方面观察藿朴夏苓汤加减治疗慢性浅表性胃炎(脾胃湿热证)的疗效并探讨其可能的作用机理,为临床新药研究提供理论依据。
方法
选取湖北省中医院消化内科门诊就诊及住院病人100份(经胃镜及病理检查后确诊为慢性浅表性胃炎,中医辨证为脾胃湿热证),随机将其分为治疗组(中西药结合组)及对照组(单纯西药组)各50例。两组患者在治疗前性别、年龄、病程、主要中医症候、中医症候积分、胃镜检查情况、病理检查情况、幽门螺杆菌(HP)感染情况方面的比较均无显著性差异(P＞0.05),具有可比性。
对照组给予单纯西药治疗,治疗组在同种西药的基础上再给予藿朴夏苓汤加减方治疗。两组病例中有反酸者给予奥美拉唑肠溶胶囊(奥克,口服,20mg/次,2次/日)抑酸,有胃排空障碍及十二指肠液反流者给予吗丁啉片(口服,10mg/次,3次/日)促胃动力,有胃黏膜充血、糜烂严重者给予硫糖铝混悬液(舒可捷,口服,5ml/次,3次/日)保护胃粘膜,HP阳性病例同时给予克拉霉素缓释片(康婷,口服,250mg/次,2次/日),阿莫西林胶囊(抗之霸,口服,1.0g/次,2次/日)等药物治疗。治疗组同时给予藿朴夏苓汤加减(由藿香15g、厚朴10g、半夏10g、赤茯苓10g、白蔻仁6g、陈皮10g、玄胡10g、黄连6g、苍术15g、白术10g、蒲公英20g、炙甘草6g等组成)治疗,水煎温服日一剂,一剂分两次服用,200ml/次。
两组病例均以四周为一疗程,服药一疗程后进行疗效判定。观察两组患者治疗后临床总疗效、主要中医症候及积分改善情况、胃镜检查情况、病理检查情况及Hp阴转情况。
结果
治疗后治疗组临床总疗效为92.0%,对照组为78.0%,经统计学分析,P＜0.05,具有显著性差异;治疗组在中医症候疗效的总有效率为96.0%,对照组为78.0%,经统计学分析P＜0.05,具有显著性差异;治疗组中医症候积分、中医主、次症积分改善方面均优于对照组(P＜0.05);治疗组在胃镜像、病理变化方面的有效率分别为:76.0%、82.0%,对照组分别为:58.0%、62.0%,治疗组在这两方面的改善均优于对照组(P＜0.05);但治疗组HP阴转率为45.4%,对照组为25.8%,组间比较经统计学分析,P＞0.05,两组对Hp感染情况改善方面没有明显差异。
结论
本研究在清热燥湿、健脾益胃、理气止痛治则基础上,结合现代医学Hp感染、胃肠功能失调、胃粘膜防御机制失常等理论,选药组方藿朴夏苓汤加减结合常规西药治疗该疾病,结果显示:中西药结合治疗慢性浅表性胃炎(脾胃湿热证)有良好的临床疗效,其效果优于单纯西药组。从现代医药理论观察藿朴夏苓汤加减方可能具有抗炎止痛、提高机体免疫力、保护胃粘膜、促胃肠运动、抗Hp感染、抗肿瘤等作用,结合相关西药治疗该病时,具有协同增强的效果。说明藿朴夏苓汤加减方的组方切合临床实际,在治疗慢性浅表性胃炎(脾胃湿热证)方面确有一定疗效,值得进一步研究及推广。
OBJIECT
This thesis aims to provide theoretical basis for the study of the new clinical medicine by observing the curative effects of the Addition and Subtraction Treatment of chronic superficial gastritis (CSG) by decoction HUO PU XIA LING TANG and discussing its possible functional mechanism.
METHODS
100 patients whose diseases are diagnosed as CSG (damp-heat in spleen and stomach) after gastroscopic and pathological examinations in the digestive medical department of Hubei Traditional Chinese Medical Hospital are selected as subjects and randomly divided into two equal groups: the treatment group of CCTWM and the control group of simple western medicine. The two groups of patients are comparable since they have no significant differences before treatments in aspects of sex, age, course of disease, main traditional Chinese medical symptom, gastroscopic examination, pathological test, and Hp infection (P>0. 05 )..
In the two groups, those who show acrid regurgitation are treated by omeprazole enteric-coated tablets (swallow, 20mg every time and twice a day) . Those who have acid suppression, delayed gastric emptying and duodenal reflux are treated by Motilium tablets to promote gastric dynamics (swallow, 10mg every time and three times a day ) . Those who have hyperemia gastric mucosa and severe erosion are treated by sucralfate suspension to protect gastric mucosa (Sucralfate, swallow, 5ml every time and three times a day) . Those with severe erosion of gastric mucosa in the control group are treated by omeprazole enteric-coated tablets (swallow, 20mg every time and twice a day), clarithromycin tablets (swallow, 250mg every time and twice a day) and amoxicillin tablets (swallow, 1.0g every time and twice a day ). The treatment group is treated with decoction HUO PU XIA LING TANG, the composition of which includes agastache rugosa, magnolia officianlis, pinellia ternate, poria cocos, Amoni compacti, coix seed, almond, coptis chinensis, atractylodes lancea, atractylodes, eupatorium fortune and taraxacum herb. Take these herbal decoctions with luke warm water, 200ml every time and twice a day.
One treatment period is 4 weeks for each groups. The curative effects will be judged after the patients have taken the medicine for one period. What need observing include the total effective rate of patients in the two groups, main CTM symptoms and the improvements of the integrals and the results of gastroscopic and pathological examinations and Hp negative-conversion.
RESULTS
After the treatment, the total curative effect of the treatment group is 92.0% and the control group 78.0%. The statistic analysis reveals that when P<0. 05, it has significant differences. The total effective rate of the treament group in the Chinese medical symptom is 96. 0% and the control group 78.0%. Statistics reveals that when P< 0. 05, it has significant differences. Traditional Chinese medicine syndrome integrals of the treatment group and the improvement of the main and minor syndrome integrals are better than that of the control group ( P < 0. 05 ) . The effective rate of the treatment group in gastroscopic examinations and pathological changes are 76.0% and 82.0% respectively while the control group 58.0% and 62.0%. The improvement of the treatment group is obviously better than that of the control group (P<0. 05 ) , but the rate of Hp negative-conversion is 45.4% while the control group 25.8%. The statistic analysis shows that when P > 0. 05, the two groups have no significant differences in avoiding Hp infection.
CONCLUSION
Based on the traditional methods of heat-clearing and damp-drying, invigorating spleen and stomach and regulating Qi and analgesia with a combination of the theories of modern medical science such as Hp inflection, gastrointestinal dysfunction and maladjustment of the mechanisms of gastric mucosal protection, this thesis decoction HUO PU XIA LING TANG usually uses western medicine to treat the disease. The result reveals that CCTWM is very effective in treating CSG, and the effect is better than that of the control group which uses western medicine only. decoction HUO PU XIA LING TANG possibly have such functions as antiinflammation and analgesia, increase body's immunity, protect gastric mucosa, enhance gastrointestinal impetus, anti Hp infection and antitumor. In treating the disease with western medicine, it has a synergetic enchanting effect. It shows that the composing prescriptions of decoction HUO PU XIA LING TANG is suitable for the clinical reality. They do have some curative effects in treating CSG (damp-heat in spleen and stomach)and are worth further study and recommending.
引文
[1]中华医学会消化病学分会.全国慢性胃炎研讨会共识意见.中华消化杂志,2000:20:199-201.
[2]吕农华.规范慢性胃炎的诊断与治疗.中华消化杂志,2005,25(2):65-66.
[3]郑嘉岗,卢林耿,段艳霞等.慢性胃炎与微观辨证分型的相关性及临床意义.中医杂志,2000;41(8):490-491.
[4]冯春霞,劳绍贤,黄志新,等.慢性浅表性胃炎脾胃湿热证胃粘膜病理幽门螺杆菌感染及胃粘膜分泌特点[J].广州中医药大学学报,2003,20(3):187-189.
[5]韩子岩,韩松岩,韩树颖.慢性胃炎中医辨证分型与悉尼内镜胃炎分类及Hp 感染相关性研究.中医杂志,2001,42(9):556-557.
[6]杨春波,傅肖岩,柯晓,等.慢性胃炎脾胃湿热证的免疫组织化学研究[J].中国中西医结合脾胃杂志,1998;(2):68-72.
[7]张群豪,郑家铿,魏德爆,等.慢性胃病脾胃湿热患者外周血T淋巴细胞亚群的观察[J].福建中医学院学报,1993,3(1):45-46.
[8]张向菊,劳绍贤,罗琦,等.慢性浅表性胃炎脾胃湿热证患者胃电图与胃排空的关系[J].广州中医药大学学报,2001,18(1):43-45.
[9]Rauws Ea,Tygat GNJ.Eradication of helicobacter pyloti cures duodenal ulcer.Lancet 1990;335:1233-1215.
[10]George 11,Borody Tj,Andrews P,etal.cure of duodenal ulcer after eradiction of helicobacter pylori.Med.J Aust 1990;153:145-149.
[11]Unge P,Ekstrom E.Effects of combinatin therapy with omeprazole and an antibiotic on helicobacter pylori and duodenal ulcer disease ulcer disease,scand J Castroenterol 1993;28:17-18.
[12]Sung JJY,chung scs,ling TKW,etal.Antibacterial treatment of gastric ulcers associated with Helicobacter pylori.Nengl J Med 1995;332:139-142.
[13]郑芝田.胃肠病学.第三版,北京:人民卫生出版社,2000,308-315
[14]李会庆,周涛,金世宽等.代谢酶基因多态性与慢性浅表性胃炎易感性关系的研究[J].中国慢性病预防与控制,2001,9(6):266.
[15]Lindhulm C,Quiding Jarbrink M,Lo North H,et al.Local cutokine response in Heticobacter pylori-infected subjects[J].Infect Immunol,1998,66:5964-5971.
[16]何杰雯.十二指肠-胃反流与胃炎关系的研究进展[J].国外医学·消化系疾病册,2004,24(2):93-96.
[17]危北海.宏观辨证与微观辨证的结合研究[J].中国中西医结合杂志,1991,11(5):301.
[18]杨春波,柯晓,祈建生,等.脾胃湿热证的临床研究[J].福建中医学院学报,1999,9(4):1.
[19]张向菊,劳绍贤,王建华等.慢性浅表性胃炎脾胃湿热证患者的胃排空功能分析[J].新中医,2001,33(3):17-19.
[20]李兆申.全国慢性胃炎诊治研讨会纪要[J].中华消化内镜杂志,2004.21(2):99.
[21]吴传发,吴庆文.抗幽门螺杆菌感染的研究进展[J].临床误诊误治,2005,18(5):365-366.
[22]甄承恩,杨晶,史斌.慢性胃炎的研究进展与思考[J].临床荟萃2005,20(2):118-121.
[23]刘尧,毛羽.广藿香挥发油止咳化痰药理实验的研究[J].时珍国医国药,2007,18(8):1920-1921.
[24]任守忠,靳德军,张俊清.广藿香药理作用研究进展[J].中国现代中医,2006,8(8):27-29.
[25]张永太,吴皓.厚朴药理学研究进展[J].中国中医药信息杂志,2005,12(5):96-99.
[26]沈映君.中药药理学[M].上海:上海科学技术出版社,1997,83.
[27]王光明,周蓉.半夏的中药药理研究进展[J].中医药导报,2007,13(2):97-99.
[28]付玲,于淼.茯苓研究的新进展[J].新疆中医药,2005,23(3):79-83.
[29]侯安继,彭施萍,项荣.茯苓多糖抗炎作用研究[J].中药药理与临床,2003,19(3):15-16.
[30]张秀明.茯苓药理作用研究概况[J].中药材,2001,24(6):446-449.
[31]侯安继,陈腾云,彭施萍等.茯苓多糖抗衰老作用研究[J].中药药理与临床,2004,20(3):10-11.
[32]雷载权,陈松育.中药学[M].上海.上海科学技术出版社,2001.129.
[33]王晓亮,郭壮丽,李桂芬等.白豆蔻的配伍应用[J].中医药信息,1998,3:28.
[34]王刚,刘红玉。温胆汤加减方治疗慢性浅表性胃炎58例[J].现代中西医结合杂志,2004,13(3):315-316.
[35]HuJY,JinGZ.Supraspinal D2 receptor involved inantino ciception induced by ltetrahy dropalmatine,hctaPharmacolSin,1999,20(8):715.
[36]李毓,王建华,劳绍贤等.延胡索乙素对离体大鼠胃酸分泌的抑制作用[J].中国药理学通报,1993,9(1):44.
[37]卞礼思,张兆霞.养胃冲剂治疗慢性浅表性胃炎的临床研究[J].中国中西医结合脾胃杂志,2000,8(4):201-203.
[38]余园媛,王伯初,彭亮等.黄连的药理研究进展[J].重庆大学学报,2006,29(2):107-111.
[39]崔学军.黄连及其有效成分的药理研究进展[J].中国药师,2006,9(5):469-470.
[40]代国友,潘晓鸥,罗红霞.黄连的药理研究进展[J].中国药房,2004,15(11):494-496.
[41]陈炎明,陈静,俞桂新.苍术化学成分和药理活性研究进展[J].上海中医药大学学报,2006,20(4):95-97.
[42]李曼玲,范莉,冯伟红等.苍术的化学药理研究进展[J].中国中医药信息杂志,2002,9(11):79-82.
[43]龙全江,徐雪琴,胡昀.白术的化学、药理与炮制研究进展[J].中国中医药信息杂志,2004,11(11):1033-1034.
[44]常怡勇.白术药理研究进展[J].中国中医药报,2004,06.
[45]吴艳玲,朴惠善.蒲公英的药理研究进展[J].时珍国医国药,2004.15(8):519-520.
[46]王访,苏耀海.甘草的药理作用及临床应用[J].时针国医中医,2002,9(5):33-34.
[1]潘相学,刘持年,周继友,等.黄连益胃灵治疗HP相关性慢性浅表性胃炎临床研究[J].山东中医杂志,2004,23(9):522.
[2]杨小琴,杨启魁.疏肝和胃汤治疗慢性浅表性胃炎76例[J].现代中医药,2005,25(4):16.
[3]陈福如.862例慢性胃炎中医病因病机分析[J].江西中医药,1997,28(1):51.
[4]李翔,孙军,侯仪,等.胃葆冲剂治疗慢性浅表性胃炎临床观察[J].中国中医药信息杂志,2004,11(9):827.
[5]沈晨君.慢性胃炎辨证施治经验[J].南通医学院学报,2003,23(4):452.
[6]马汴梁.食管胃肠病,中西医结合诊治[M].北京:人民卫生出版,2003:126-127.
[7]姚春.中医辨证治疗慢性浅表性胃炎86例[J].陕西中医,2 008,29(1):26.
[8]卢成孝.辨证治疗慢性浅表性胃炎80例[J].实用中医内科杂志,2007,21(3):33.
[9]卫永琪.辨证治疗慢性浅表性胃炎81例[J].实用中医药杂志,2005,21(1):12.
[10]阳秋辉.辨证治疗慢性浅表性胃炎89例[J].湖南中医杂志,2003,19(2):42.
[11]钟跃青,李俊达,余蓉.中西医结合治疗幽门螺杆菌阳性慢性浅表性胃炎临床观察[J].中华中西医杂志,2004,5(12):1141-1142.
[12]杨郎.辨证治疗慢性浅表性胃炎119例[J].山西中医,2004,20(1):16-17.
[13]方东行.辨证治疗慢性浅表性胃炎的体会[J].时珍国医国药,2001,12(5):443-444.
[14]卫永琪.辨证治疗慢性浅表性胃炎81例[J]。实用中医药杂志,2005,21(1):12-13.
[15]陈伟,段燕萍,毛晓曦.加味柴胡疏肝散治疗慢性浅表性胃炎临床观察[J].现代中西医结合杂志,2008,17(3):370-371.
[16]胡志明,曾玉芬.天台乌药散治疗慢性浅表性胃炎65例[J].湖南中医杂志,2006,22(5):53.
[17]彭卫.《伤寒论》经方合用治疗慢性浅表性胃炎临床观察[J].时珍国医国药,2005,16(9):904-905.
[18]孟莉,石新德.香苏散加味治疗慢性浅表性胃炎15例体会[J].中国现代医药杂志,2005,7(2):59.
[19]周帅,叶松.自拟胃炎方治疗慢性浅表性胃炎40例[J].甘肃中医学院学报,2006,23(2):31-32.
[20]黄爽明.自拟“香芍枳佛汤”治疗慢性浅表性胃炎200例[J].新疆中医药,2006,24(6):14-15.
[21]卢怡,高秀文.加味左金丸治疗慢性浅表性胃炎34例[J].齐齐哈尔医学院学报,2007,28(13):1580-1581.
[22]王钢,刘红玉.温胆汤加减方治疗慢性浅表性胃炎58例[J].现代中西医结合杂志,2004,13(3):315-316.
[23]陈学荣.加味不换金正气散治疗慢性浅表性胃炎68例[J].实用中医药杂志,2002.18(10):10-11.
[24]郝福树.自拟胃舒汤治疗慢性浅表性胃炎32例[J].中医杂志,2008.49(1):46.
[25]唐艺凯.丹半汤治疗慢性浅表性胃炎疗效观察[J].浙江中西医结合杂志,2006,16(11):693-694.
[26]张丽萍.中医辨证治疗慢性浅表性胃炎300例[J].广西中医药,2004,27(1):32-33.
[27]张爱梅.香砂六君子汤加减治疗慢性浅表性胃炎98例[J].云南中医中药杂志,2007,28(2):26-27.
[28]董品军,路康新.大建中汤加味治疗慢性表浅性胃炎80例[J].四川中医,2002.20(6):45.
[29]朱晓,王霞.加味六君子汤治疗慢性浅表性胃炎临床观察[J].潍坊医学院学报,2006,28(1):45-46
[30]黄慧琳.消胃散治疗慢性浅表性胃炎40例[J].湖北中医杂志,2005,7(3):48.
[31]万清信,王燕.健脾益胃汤治疗慢性胃炎200例观察[J]·山东中医杂志,2005.24(10):613-614.
[32]刘炳焱.活络效灵丹治疗慢性浅表性胃炎100例[J].湖南中医杂志, 2005.21(5):45.
[33]陈丽鸽.柴胡纵横汤治疗慢性浅表性胃炎[J].山东中医杂志,2003,22(9):539.
[34]龙轶谋.活血化瘀法治疗慢性浅表性胃炎60例小结[J].中医药导报,2005,11(2):25-26.
[35]张丙臣.辨证治疗慢性胃炎187例体会[J].河南中医,2005,2 5(5):42-44.
[36]赵学魁.麦门冬汤加减治疗慢性浅表性胃炎的体会[J].上海中医药杂志,2004,38(4):10.
[37]廖风华.女贞百合汤加减治疗慢性浅表性胃炎30例总结[J].湖南中医杂志,2005,21(1):14-15.
[38]吴正平.自拟胃康汤治疗慢性浅表性胃炎110例[J].辽宁中医杂志,2006,33(7):847.
[39]胡联中,刘旺兴.百合地黄汤加味治疗慢性浅表性胃炎37例[J].湖南中医杂志,2001,17(1):38-39.
[40]阳光.黄芪建中汤加减治疗慢性浅表性胃炎31例[J].广西中医药,2006,29(3):42.
[41]廖学运,钟祖群,钟祖健等.自拟温土汤治疗慢性浅表性胃炎65例疗效观察[J].四川中医,2007,25(10):74-75.
[42]郝秀云.枳实消痞汤加减治疗慢性浅表性胃炎69例[J].安徽中医临床杂志,2002,14(2):110.
[43]段庆银.清肺宣降法治疗慢性浅表性胃炎150例[J].国医论坛,2002,17(1):2.
[44]朱瑞华,方颖.加味半夏泻心汤治疗慢性浅表性胃炎143例[J].河北中医,2005,27(10):754-755.
[45]戚丽娟,王新春.和胃止痛丸治疗慢性浅表性胃炎临床疗效观察[J].医药世界,2005,7(7):638-639.
[46]洪彰福,张茂.胃宁口服液治疗慢性浅表性胃炎的临床观察[J].中国中西医结合消化杂志,2004,12(4):215-217.
[47]吕翠岩,丁舟.加味平胃散合半夏厚朴汤治疗慢性浅表性胃炎51例临床观察[J].北京中医,2007,26(11):731-732.
[48]步培良.半夏厚朴汤加味治疗慢性浅表性胃炎98例[J].吉林中医药,2002,22(4):14.
[49]郑逢民.吴茱萸汤治疗肝寒犯胃型慢性浅表性胃炎150例[J].浙江中医杂志,2004,39(4):153.
[50]杨光升.半夏泻心汤结合西药治疗慢性浅表性胃炎(HP阳性)[J].中国实用医药,2007,2(16):93.
[51]周才根,刘镇中,杨少华.中西医结合治疗慢性浅表性胃炎66例疗效观察[J].实用中西医结合临床,2005,5(2):39-40.
[52]林孔孝.中西医结合治疗慢性浅表性胃炎78例[J].浙江中西医结合杂志,2004,14(12):748-749.
[53]孙继铭,王维武.和胃汤雷尼替丁并用治疗HP阴性浅表性胃炎38例[J].中医药学刊,2003,21(2):2143-2144.
[54]丹壁.短波加针刺治疗慢性浅表性胃炎56例分析[J].中国误诊学杂志,2008,8(1):182.
[55]林源,姚志芳,陈旭军.针药结合治疗慢性浅表性胃炎[J].针灸临床杂志,2007,23(11):23-24.
[56]朱秀平,朱美群,黄少姬.穴位贴敷配合穴位埋线治疗慢性浅表性胃炎的临床疗效观察[J].针灸临床杂志,2007,23(6):1-3.
[57]辛银虎,陈小玲.温针治疗脾胃虚寒型慢性浅表性胃炎52例[J].陕西中医,2005,26(9):959-960.
[58]罗凛.推拿治疗慢性浅表性胃炎42例疗效观察[J].河北中医,2004,26(8):611-612.
[59]张万岱.幽门螺杆菌研究的现状与展望[J].中华消化杂志,1998,18(1):513.
[2]吕农华.规范慢性胃炎的诊断与治疗.中华消化杂志,2005,25(2):65-66.
[3]郑嘉岗,卢林耿,段艳霞等.慢性胃炎与微观辨证分型的相关性及临床意义.中医杂志,2000;41(8):490-491.
[4]冯春霞,劳绍贤,黄志新,等.慢性浅表性胃炎脾胃湿热证胃粘膜病理幽门螺杆菌感染及胃粘膜分泌特点[J].广州中医药大学学报,2003,20(3):187-189.
[5]韩子岩,韩松岩,韩树颖.慢性胃炎中医辨证分型与悉尼内镜胃炎分类及Hp 感染相关性研究.中医杂志,2001,42(9):556-557.
[6]杨春波,傅肖岩,柯晓,等.慢性胃炎脾胃湿热证的免疫组织化学研究[J].中国中西医结合脾胃杂志,1998;(2):68-72.
[7]张群豪,郑家铿,魏德爆,等.慢性胃病脾胃湿热患者外周血T淋巴细胞亚群的观察[J].福建中医学院学报,1993,3(1):45-46.
[8]张向菊,劳绍贤,罗琦,等.慢性浅表性胃炎脾胃湿热证患者胃电图与胃排空的关系[J].广州中医药大学学报,2001,18(1):43-45.
[9]Rauws Ea,Tygat GNJ.Eradication of helicobacter pyloti cures duodenal ulcer.Lancet 1990;335:1233-1215.
[10]George 11,Borody Tj,Andrews P,etal.cure of duodenal ulcer after eradiction of helicobacter pylori.Med.J Aust 1990;153:145-149.
[11]Unge P,Ekstrom E.Effects of combinatin therapy with omeprazole and an antibiotic on helicobacter pylori and duodenal ulcer disease ulcer disease,scand J Castroenterol 1993;28:17-18.
[12]Sung JJY,chung scs,ling TKW,etal.Antibacterial treatment of gastric ulcers associated with Helicobacter pylori.Nengl J Med 1995;332:139-142.
[13]郑芝田.胃肠病学.第三版,北京:人民卫生出版社,2000,308-315
[14]李会庆,周涛,金世宽等.代谢酶基因多态性与慢性浅表性胃炎易感性关系的研究[J].中国慢性病预防与控制,2001,9(6):266.
[15]Lindhulm C,Quiding Jarbrink M,Lo North H,et al.Local cutokine response in Heticobacter pylori-infected subjects[J].Infect Immunol,1998,66:5964-5971.
[16]何杰雯.十二指肠-胃反流与胃炎关系的研究进展[J].国外医学·消化系疾病册,2004,24(2):93-96.
[17]危北海.宏观辨证与微观辨证的结合研究[J].中国中西医结合杂志,1991,11(5):301.
[18]杨春波,柯晓,祈建生,等.脾胃湿热证的临床研究[J].福建中医学院学报,1999,9(4):1.
[19]张向菊,劳绍贤,王建华等.慢性浅表性胃炎脾胃湿热证患者的胃排空功能分析[J].新中医,2001,33(3):17-19.
[20]李兆申.全国慢性胃炎诊治研讨会纪要[J].中华消化内镜杂志,2004.21(2):99.
[21]吴传发,吴庆文.抗幽门螺杆菌感染的研究进展[J].临床误诊误治,2005,18(5):365-366.
[22]甄承恩,杨晶,史斌.慢性胃炎的研究进展与思考[J].临床荟萃2005,20(2):118-121.
[23]刘尧,毛羽.广藿香挥发油止咳化痰药理实验的研究[J].时珍国医国药,2007,18(8):1920-1921.
[24]任守忠,靳德军,张俊清.广藿香药理作用研究进展[J].中国现代中医,2006,8(8):27-29.
[25]张永太,吴皓.厚朴药理学研究进展[J].中国中医药信息杂志,2005,12(5):96-99.
[26]沈映君.中药药理学[M].上海:上海科学技术出版社,1997,83.
[27]王光明,周蓉.半夏的中药药理研究进展[J].中医药导报,2007,13(2):97-99.
[28]付玲,于淼.茯苓研究的新进展[J].新疆中医药,2005,23(3):79-83.
[29]侯安继,彭施萍,项荣.茯苓多糖抗炎作用研究[J].中药药理与临床,2003,19(3):15-16.
[30]张秀明.茯苓药理作用研究概况[J].中药材,2001,24(6):446-449.
[31]侯安继,陈腾云,彭施萍等.茯苓多糖抗衰老作用研究[J].中药药理与临床,2004,20(3):10-11.
[32]雷载权,陈松育.中药学[M].上海.上海科学技术出版社,2001.129.
[33]王晓亮,郭壮丽,李桂芬等.白豆蔻的配伍应用[J].中医药信息,1998,3:28.
[34]王刚,刘红玉。温胆汤加减方治疗慢性浅表性胃炎58例[J].现代中西医结合杂志,2004,13(3):315-316.
[35]HuJY,JinGZ.Supraspinal D2 receptor involved inantino ciception induced by ltetrahy dropalmatine,hctaPharmacolSin,1999,20(8):715.
[36]李毓,王建华,劳绍贤等.延胡索乙素对离体大鼠胃酸分泌的抑制作用[J].中国药理学通报,1993,9(1):44.
[37]卞礼思,张兆霞.养胃冲剂治疗慢性浅表性胃炎的临床研究[J].中国中西医结合脾胃杂志,2000,8(4):201-203.
[38]余园媛,王伯初,彭亮等.黄连的药理研究进展[J].重庆大学学报,2006,29(2):107-111.
[39]崔学军.黄连及其有效成分的药理研究进展[J].中国药师,2006,9(5):469-470.
[40]代国友,潘晓鸥,罗红霞.黄连的药理研究进展[J].中国药房,2004,15(11):494-496.
[41]陈炎明,陈静,俞桂新.苍术化学成分和药理活性研究进展[J].上海中医药大学学报,2006,20(4):95-97.
[42]李曼玲,范莉,冯伟红等.苍术的化学药理研究进展[J].中国中医药信息杂志,2002,9(11):79-82.
[43]龙全江,徐雪琴,胡昀.白术的化学、药理与炮制研究进展[J].中国中医药信息杂志,2004,11(11):1033-1034.
[44]常怡勇.白术药理研究进展[J].中国中医药报,2004,06.
[45]吴艳玲,朴惠善.蒲公英的药理研究进展[J].时珍国医国药,2004.15(8):519-520.
[46]王访,苏耀海.甘草的药理作用及临床应用[J].时针国医中医,2002,9(5):33-34.
[1]潘相学,刘持年,周继友,等.黄连益胃灵治疗HP相关性慢性浅表性胃炎临床研究[J].山东中医杂志,2004,23(9):522.
[2]杨小琴,杨启魁.疏肝和胃汤治疗慢性浅表性胃炎76例[J].现代中医药,2005,25(4):16.
[3]陈福如.862例慢性胃炎中医病因病机分析[J].江西中医药,1997,28(1):51.
[4]李翔,孙军,侯仪,等.胃葆冲剂治疗慢性浅表性胃炎临床观察[J].中国中医药信息杂志,2004,11(9):827.
[5]沈晨君.慢性胃炎辨证施治经验[J].南通医学院学报,2003,23(4):452.
[6]马汴梁.食管胃肠病,中西医结合诊治[M].北京:人民卫生出版,2003:126-127.
[7]姚春.中医辨证治疗慢性浅表性胃炎86例[J].陕西中医,2 008,29(1):26.
[8]卢成孝.辨证治疗慢性浅表性胃炎80例[J].实用中医内科杂志,2007,21(3):33.
[9]卫永琪.辨证治疗慢性浅表性胃炎81例[J].实用中医药杂志,2005,21(1):12.
[10]阳秋辉.辨证治疗慢性浅表性胃炎89例[J].湖南中医杂志,2003,19(2):42.
[11]钟跃青,李俊达,余蓉.中西医结合治疗幽门螺杆菌阳性慢性浅表性胃炎临床观察[J].中华中西医杂志,2004,5(12):1141-1142.
[12]杨郎.辨证治疗慢性浅表性胃炎119例[J].山西中医,2004,20(1):16-17.
[13]方东行.辨证治疗慢性浅表性胃炎的体会[J].时珍国医国药,2001,12(5):443-444.
[14]卫永琪.辨证治疗慢性浅表性胃炎81例[J]。实用中医药杂志,2005,21(1):12-13.
[15]陈伟,段燕萍,毛晓曦.加味柴胡疏肝散治疗慢性浅表性胃炎临床观察[J].现代中西医结合杂志,2008,17(3):370-371.
[16]胡志明,曾玉芬.天台乌药散治疗慢性浅表性胃炎65例[J].湖南中医杂志,2006,22(5):53.
[17]彭卫.《伤寒论》经方合用治疗慢性浅表性胃炎临床观察[J].时珍国医国药,2005,16(9):904-905.
[18]孟莉,石新德.香苏散加味治疗慢性浅表性胃炎15例体会[J].中国现代医药杂志,2005,7(2):59.
[19]周帅,叶松.自拟胃炎方治疗慢性浅表性胃炎40例[J].甘肃中医学院学报,2006,23(2):31-32.
[20]黄爽明.自拟“香芍枳佛汤”治疗慢性浅表性胃炎200例[J].新疆中医药,2006,24(6):14-15.
[21]卢怡,高秀文.加味左金丸治疗慢性浅表性胃炎34例[J].齐齐哈尔医学院学报,2007,28(13):1580-1581.
[22]王钢,刘红玉.温胆汤加减方治疗慢性浅表性胃炎58例[J].现代中西医结合杂志,2004,13(3):315-316.
[23]陈学荣.加味不换金正气散治疗慢性浅表性胃炎68例[J].实用中医药杂志,2002.18(10):10-11.
[24]郝福树.自拟胃舒汤治疗慢性浅表性胃炎32例[J].中医杂志,2008.49(1):46.
[25]唐艺凯.丹半汤治疗慢性浅表性胃炎疗效观察[J].浙江中西医结合杂志,2006,16(11):693-694.
[26]张丽萍.中医辨证治疗慢性浅表性胃炎300例[J].广西中医药,2004,27(1):32-33.
[27]张爱梅.香砂六君子汤加减治疗慢性浅表性胃炎98例[J].云南中医中药杂志,2007,28(2):26-27.
[28]董品军,路康新.大建中汤加味治疗慢性表浅性胃炎80例[J].四川中医,2002.20(6):45.
[29]朱晓,王霞.加味六君子汤治疗慢性浅表性胃炎临床观察[J].潍坊医学院学报,2006,28(1):45-46
[30]黄慧琳.消胃散治疗慢性浅表性胃炎40例[J].湖北中医杂志,2005,7(3):48.
[31]万清信,王燕.健脾益胃汤治疗慢性胃炎200例观察[J]·山东中医杂志,2005.24(10):613-614.
[32]刘炳焱.活络效灵丹治疗慢性浅表性胃炎100例[J].湖南中医杂志, 2005.21(5):45.
[33]陈丽鸽.柴胡纵横汤治疗慢性浅表性胃炎[J].山东中医杂志,2003,22(9):539.
[34]龙轶谋.活血化瘀法治疗慢性浅表性胃炎60例小结[J].中医药导报,2005,11(2):25-26.
[35]张丙臣.辨证治疗慢性胃炎187例体会[J].河南中医,2005,2 5(5):42-44.
[36]赵学魁.麦门冬汤加减治疗慢性浅表性胃炎的体会[J].上海中医药杂志,2004,38(4):10.
[37]廖风华.女贞百合汤加减治疗慢性浅表性胃炎30例总结[J].湖南中医杂志,2005,21(1):14-15.
[38]吴正平.自拟胃康汤治疗慢性浅表性胃炎110例[J].辽宁中医杂志,2006,33(7):847.
[39]胡联中,刘旺兴.百合地黄汤加味治疗慢性浅表性胃炎37例[J].湖南中医杂志,2001,17(1):38-39.
[40]阳光.黄芪建中汤加减治疗慢性浅表性胃炎31例[J].广西中医药,2006,29(3):42.
[41]廖学运,钟祖群,钟祖健等.自拟温土汤治疗慢性浅表性胃炎65例疗效观察[J].四川中医,2007,25(10):74-75.
[42]郝秀云.枳实消痞汤加减治疗慢性浅表性胃炎69例[J].安徽中医临床杂志,2002,14(2):110.
[43]段庆银.清肺宣降法治疗慢性浅表性胃炎150例[J].国医论坛,2002,17(1):2.
[44]朱瑞华,方颖.加味半夏泻心汤治疗慢性浅表性胃炎143例[J].河北中医,2005,27(10):754-755.
[45]戚丽娟,王新春.和胃止痛丸治疗慢性浅表性胃炎临床疗效观察[J].医药世界,2005,7(7):638-639.
[46]洪彰福,张茂.胃宁口服液治疗慢性浅表性胃炎的临床观察[J].中国中西医结合消化杂志,2004,12(4):215-217.
[47]吕翠岩,丁舟.加味平胃散合半夏厚朴汤治疗慢性浅表性胃炎51例临床观察[J].北京中医,2007,26(11):731-732.
[48]步培良.半夏厚朴汤加味治疗慢性浅表性胃炎98例[J].吉林中医药,2002,22(4):14.
[49]郑逢民.吴茱萸汤治疗肝寒犯胃型慢性浅表性胃炎150例[J].浙江中医杂志,2004,39(4):153.
[50]杨光升.半夏泻心汤结合西药治疗慢性浅表性胃炎(HP阳性)[J].中国实用医药,2007,2(16):93.
[51]周才根,刘镇中,杨少华.中西医结合治疗慢性浅表性胃炎66例疗效观察[J].实用中西医结合临床,2005,5(2):39-40.
[52]林孔孝.中西医结合治疗慢性浅表性胃炎78例[J].浙江中西医结合杂志,2004,14(12):748-749.
[53]孙继铭,王维武.和胃汤雷尼替丁并用治疗HP阴性浅表性胃炎38例[J].中医药学刊,2003,21(2):2143-2144.
[54]丹壁.短波加针刺治疗慢性浅表性胃炎56例分析[J].中国误诊学杂志,2008,8(1):182.
[55]林源,姚志芳,陈旭军.针药结合治疗慢性浅表性胃炎[J].针灸临床杂志,2007,23(11):23-24.
[56]朱秀平,朱美群,黄少姬.穴位贴敷配合穴位埋线治疗慢性浅表性胃炎的临床疗效观察[J].针灸临床杂志,2007,23(6):1-3.
[57]辛银虎,陈小玲.温针治疗脾胃虚寒型慢性浅表性胃炎52例[J].陕西中医,2005,26(9):959-960.
[58]罗凛.推拿治疗慢性浅表性胃炎42例疗效观察[J].河北中医,2004,26(8):611-612.
[59]张万岱.幽门螺杆菌研究的现状与展望[J].中华消化杂志,1998,18(1):513.