液相色谱—串联质谱联用技术在食品安全分析中的应用
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摘要
对复杂基质中痕量成分的多残留组分分析和确证分析已成为食品安全分析的重大难题。传统的仪器检测方法对这一问题难以解决,如气相色谱法(GC)、液相色谱法(LC)、气相色谱质谱法(GC-MS)等。液相色谱-串联质谱联用技术(LC-MS/MS)结合了液相色谱、串联质谱两者的优点,不仅分离能力强,选择性好,灵敏度高,而且还可以对复杂基质样品中的痕量成分进行确证分析,已成为食品安全分析手段中必不可少的组成部分。
本论文主要内容如下:
(1)本文对食品安全问题和食品分析的现状进行了概述,并对液相色谱-串联质谱联用技术的基本原理和发展以及其在食品分析中的应用进行了综述。
(2)采用液相色谱-串联质谱法(LC-MS/MS)进行了水产品中三苯甲烷类药物的残留分析研究。同时测定了水产品中的孔雀石绿、结晶紫以及它们的隐色代谢物残留。将匀质后的水产品样品,用乙腈和乙酸铵缓冲液提取,合并提取液,用二氯甲烷反提取,经中性氧化铝柱和PRS柱固相萃取净化,没有使用氧化铅柱在线氧化,色谱分离后直接进入串联质谱检测器。采用电喷雾正离子,多反应检测(MRM)模式检测。方法的检测限可达0.5ng/g,添加样品平均回收率为77.6%～98.1%,相对标准偏差均小于8.2%。
(3)采用液相色谱-串联质谱法(LC-MS/MS)同时测定了蜂王浆中氯霉素,甲砜霉素和氟甲砜霉素残留。样品加入阴性蜂蜜和水均质后,采用乙酸乙酯提取,蒸发浓缩,C_(18)固相萃取净化。HPLC分离后,串联质谱法以电喷雾负离子多反应监测方式(MRM)进行定性定量分析。通过对固相萃取条件的优化,大大减小了基质的干扰。氯霉素,氟甲砜霉素和甲砜霉素的检出限分别为0.1ng/g,0.2ng/g和0.5ng/g,平均回收率为79.9%～88.4%,相对标准偏差(RSD)均小于8.2%。
Confirmatory multiresidue analysis for organic compounds at trace levels in complex matrixes is required in food analysis. Conventional techniques in food analysis, such as Gas chromatography (GC), Liquid chromatography (LC), Gas chromatography mass spectrometry (GC-MS), etc., can’t meet the demands. Liquid chromatography tandem mass spectrometry (LC-MS/MS) technique frequently provides specific, selective and sensitive quantitative results, and allows unequivocal identification of traces of contaminants in complex food matrices, which has become one of the major tools in food analysis.
The main contents in this thesis are described as follows:
(1)The paper reviews the importance of food safety and the status of food analysis, and introduces the basic principle, characteristics of LC-MS/MS and its application in food analysis.
(2)A liquid chromatography tandem mass spectrometry (LC-MS/MS) method was described for Simultaneous determination of residues of malachite green (MG),leucomalachite green(LMG),rystal violet(CV)and leucocrystal violet(LCV) in aquatic products. The targeted analytes were extracted from homogenized samples with a mixture of acetonitrile and ammonium acetate buffer, partitioned against methylene chloride, and purified on tandem neutral alumina and PRS SPE cartridges. Chromatographic Separation was achieved by using ZORBAX SB-C18 column with an isocratic mobile phase consisting of ammonium acetate (0.05mM) and acetonitrile(10/90,V/V)without the need for in-line post-column oxidation with PbO_2. Identification and quantification were performed using multiple reaction monitoring (MRM) with one precursor ion and two product ions for each analyte and electrospray ionization in positive mode. Limits of detection were 0.5ng/g. Recoveries were in the range of 77.6%～98.1%, and the RSDs were less than 8.2%.
(3)A method was presented for simultaneous determination residues of Chloramphenicol (CAP),Thiamphenicol (TAP) and Florfenicol (FF) in royal jelly by using high performance liquid chromatography tandem mass spectrometry (LC–MS/MS).After a preliminary homogenization in negative honey and water, samples were extracted with ethyl acetate, and evaporated to dryness; the following clean up was carried out on a C18 SPE cartridge. After reversed-phase HPLC separation, identification and quantification were performed using multiple reaction monitoring (MRM) and electrospray ionization in negative mode. In order to dispel the matrix interference, the conditions of solid phase extraction were optimized. The detection limits of the method were 0.1ng/g,0.2ng/g and 0.5ng/g for CAP, FF and TAP, respectively. The average recoveries were 79.9%~88.4%, and the RSD were lower than 8.2.%.
本论文主要内容如下:
(1)本文对食品安全问题和食品分析的现状进行了概述,并对液相色谱-串联质谱联用技术的基本原理和发展以及其在食品分析中的应用进行了综述。
(2)采用液相色谱-串联质谱法(LC-MS/MS)进行了水产品中三苯甲烷类药物的残留分析研究。同时测定了水产品中的孔雀石绿、结晶紫以及它们的隐色代谢物残留。将匀质后的水产品样品,用乙腈和乙酸铵缓冲液提取,合并提取液,用二氯甲烷反提取,经中性氧化铝柱和PRS柱固相萃取净化,没有使用氧化铅柱在线氧化,色谱分离后直接进入串联质谱检测器。采用电喷雾正离子,多反应检测(MRM)模式检测。方法的检测限可达0.5ng/g,添加样品平均回收率为77.6%～98.1%,相对标准偏差均小于8.2%。
(3)采用液相色谱-串联质谱法(LC-MS/MS)同时测定了蜂王浆中氯霉素,甲砜霉素和氟甲砜霉素残留。样品加入阴性蜂蜜和水均质后,采用乙酸乙酯提取,蒸发浓缩,C_(18)固相萃取净化。HPLC分离后,串联质谱法以电喷雾负离子多反应监测方式(MRM)进行定性定量分析。通过对固相萃取条件的优化,大大减小了基质的干扰。氯霉素,氟甲砜霉素和甲砜霉素的检出限分别为0.1ng/g,0.2ng/g和0.5ng/g,平均回收率为79.9%～88.4%,相对标准偏差(RSD)均小于8.2%。
Confirmatory multiresidue analysis for organic compounds at trace levels in complex matrixes is required in food analysis. Conventional techniques in food analysis, such as Gas chromatography (GC), Liquid chromatography (LC), Gas chromatography mass spectrometry (GC-MS), etc., can’t meet the demands. Liquid chromatography tandem mass spectrometry (LC-MS/MS) technique frequently provides specific, selective and sensitive quantitative results, and allows unequivocal identification of traces of contaminants in complex food matrices, which has become one of the major tools in food analysis.
The main contents in this thesis are described as follows:
(1)The paper reviews the importance of food safety and the status of food analysis, and introduces the basic principle, characteristics of LC-MS/MS and its application in food analysis.
(2)A liquid chromatography tandem mass spectrometry (LC-MS/MS) method was described for Simultaneous determination of residues of malachite green (MG),leucomalachite green(LMG),rystal violet(CV)and leucocrystal violet(LCV) in aquatic products. The targeted analytes were extracted from homogenized samples with a mixture of acetonitrile and ammonium acetate buffer, partitioned against methylene chloride, and purified on tandem neutral alumina and PRS SPE cartridges. Chromatographic Separation was achieved by using ZORBAX SB-C18 column with an isocratic mobile phase consisting of ammonium acetate (0.05mM) and acetonitrile(10/90,V/V)without the need for in-line post-column oxidation with PbO_2. Identification and quantification were performed using multiple reaction monitoring (MRM) with one precursor ion and two product ions for each analyte and electrospray ionization in positive mode. Limits of detection were 0.5ng/g. Recoveries were in the range of 77.6%～98.1%, and the RSDs were less than 8.2%.
(3)A method was presented for simultaneous determination residues of Chloramphenicol (CAP),Thiamphenicol (TAP) and Florfenicol (FF) in royal jelly by using high performance liquid chromatography tandem mass spectrometry (LC–MS/MS).After a preliminary homogenization in negative honey and water, samples were extracted with ethyl acetate, and evaporated to dryness; the following clean up was carried out on a C18 SPE cartridge. After reversed-phase HPLC separation, identification and quantification were performed using multiple reaction monitoring (MRM) and electrospray ionization in negative mode. In order to dispel the matrix interference, the conditions of solid phase extraction were optimized. The detection limits of the method were 0.1ng/g,0.2ng/g and 0.5ng/g for CAP, FF and TAP, respectively. The average recoveries were 79.9%~88.4%, and the RSD were lower than 8.2.%.
引文
[1]沈富林,顾欣,庞雅君.欧盟国家兽药残留数据库介绍[J].中国兽药杂志, 2005, 39(12): 36-38
[2]陶纯洁,朱燕平,王旭峰.食品安全现状及食品安全检测技术应用浅析[J].粮食与食品工业, 2006, 13(5): 14-17
[3] C. Soler, Y. Pico′. Recent trends in liquid chromatography tandem mass spectrometry to determine pesticides and their metabolites in food[J]. Trends in Analytical Chemistry, 2006
[4] European Commission, Commission Decision 2002/657/CE implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results[J], Off. J. Eur. Commun. L, 2002, 221: 8-17
[5]刘密新,杨成对.液相色谱-质谱仪的近期进展[J].分析测试学报, 2004, 23(10): 151-154
[6] D. Barcelo. LC–tandem MS[J]. Trends in Analytical Chemistry, 2005, 24: 564-565
[7] D. B. Robb, T. R. Covey, A. P. Bruins. Atmospheric Pressure Photoionization: An Ionization Method for Liquid Chromatography-Mass Spectrometry[J]. Anal Chem. 2000, 72: 3653-3659
[8] T. J. Kauppila, T. Kotiaho, R. Kostiainen. Negative Ion-Atmospheric Pressure Photoionization-Mass Spectrometry[J]. J Am Soc Mass Spectrom, 2004, 15: 203-211
[9] T. J. Kauppila, P. Ostman, S. Marttila, et al. Atmospheric Pressure Photoionization-Mass Spectrometry with a Microchip Heated Nebulizer[J]. Anal. Chem, 2004, 76: 6797-6801
[10] S. A. C. Wren. Simultaneous determination of malachite green, gentian violet and their leuco metabolites in catfish or trout tissue by highperformance liquid chromatography with ultravioletvisible detection[J]. J. Pharm. Biomed. Anal, 2005, 38: 337-340
[11] T. Kovalczuk, M. Jech, J. Poustka, et al. Ultra-performance liquid chromatography–tandem mass spectrometry: A novel challenge in multiresiduepesticide analysis in food[J]. Analytica Chimica Acta, 2006, 577: 8-17
[12] J. M. Marín, J. V. Sancho, O. J. Pozo, et al. Quantification and confirmation of anionic, cationic and neutral pesticides and transformation products in water by on-line solid phase extraction–liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr. A, 2006, 1133: 204-214
[13] C. Blasco, G. Font, J. Manes, et al. Solid-Phase Microextraction Liquid Chromatography/Tandem Mass Spectrometry ToDetermine Postharvest Fungicides in Fruits[J]. Anal. Chem, 2003, 75: 3606-3615
[14] T. Goto, Y. Ito, H. Oka, I. Saito, et al. The high throughput analysis of N-methyl carbamate pesticides in wine and juice by electrospray ionization liquid chromatography tandem mass spectrometry with direct sample injection into a short column[J]. Anal. Chim. Acta, 2005, 531: 79-86
[15]徐远金,李永库.液相色谱-电喷雾质谱联用法测定蔬菜中7种有机磷农药残留量.分析测试学报, 2006, 25(4): 36-40
[16] G. F. Pang, Y. Z. Cao, J. J. Zhang, et al. Validation study on 660 pesticide residues in animal tissues by gel permeation chromatography cleanup/gas chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr A, 2006, 1125: 1-30
[17] F. Hernández, O. J. Pozo, J. V. Sancho, et al. Multiresidue liquid chromatography tandem mass spectrometry determination of 52 non gas chromatography-amenable pesticides and metabolites in different food commodities[J]. J. Chromatogr A, 2006, 1109: 242-252
[18] E. M. Thurman, I. Ferrer, J. A. Zweigenbaum, et al. Discovering metabolites of post-harvest fungicides in citrus with liquid chromatography/time-of-flight mass spectrometry and ion trap tandem mass spectrometry[J]. J. Chromatogr A, 2005, 1082: 71-82
[19] J. F. G. Reyes, I. Ferrer, E. M. Thurman, et al. Rapid Commun[J]. Mass Spectrom. , 2005, 19: 2780
[20] B. A. Ingelse, R. C. J. van Dam, R. J. Vreeken, et al. Determination of polar organophosphorus pesticides in aqueous samples by direct injection using liquidchromatography–tandem mass spectrometry[J]. J. Chromatogr A, 2001, 918: 67-78
[21] H. G. J. Mol, R. C. J. Dam, O. M. Steijger. Determination of polar organophosphorus pesticides in vegetables and fruits using liquid chromatography with tandem mass spectrometry: selection of extraction solvent[J]. J. Chromatogr A, 2003, 1015: 119-127
[22] T. Goto, Y. Ito, S. Yamada, et al. The high throughput analysis of N-methyl carbamate pesticides in fruits and vegetables by liquid chromatography electrospray ionization tandem mass spectrometry using a short column[J]. Anal. Chim. . Acta, 2006, 555: 225-232
[23] S. Riediker, H. Obrist, N. Varga, et al. Determination of chlormequat and mepiquat in pear, tomato, and wheat flour using on-line solid-phase extraction (Prospekt) coupled with liquid chromatography–electrospray ionization tandem mass spectrometry[J]. J. Chromatogr A, 2002, 966: 15-23
[24] I. Ferrer, E. Thurman, J. Zweigenbaum.液相飞行时间质谱(LC /MSD TOF)和液相色谱/离子阱质谱(LC /MSD Trap)测定色拉蔬菜中的氯烟碱类杀虫剂[J].环境化学, 2005, 24(3): 349-354
[25]谢文,丁慧瑛,蒋晓英等.液相色谱-串联质谱检测蔬菜和茶叶中吡虫啉的残留量[J].色谱, 2006, 24(6): 633-635
[26] C. Blasco, G. Font , Y. Picó. Multiple-stage mass spectrometric analysis of six pesticides in oranges by liquid chromatography–atmospheric pressure chemical ionization–ion trap mass spectrometry[J]. J. Chromatogr A, 2004, 1043: 231-238
[27] T. Zamora, O. J. Pozo, F. J. López, et al. Determination of tridemorph and other fungicide residues in fruit samples by liquid chromatography–electrospray tandem mass spectrometry[J]. J. Chromatogr A, 2004, 1045: 137-143
[28] J. V. Sancho, M. Ibá?ez, S. Grimalt, et al. Residue determination of cyromazine and its metabolite melamine in chard samples by ion-pair liquid chromatography coupled to electrospray tandem mass spectrometry[J]. Anal. Chim. . Acta, 2005, 530: 237-243
[29] O. J. Pozo, J. M. Marin, J. V. Sancho, et al. Determination of abamectin and azadirachtin residues in orange samples by liquid chromatography–electrospray tandem mass spectrometry[J]. J. Chromatogr A, 2003, 992: 133-140
[30] C. Soler, B. Hamilton, A. Furey, et al. Optimization of LC–MS/MS using triple quadrupole mass analyzer for the simultaneous analysis of carbosulfan and its main metabolites in oranges[J]. Anal. Chim. . Acta, 2006, 571: 1-11
[31] A. G. Frenich, J. L. M. Vidal, T. López, et al. Monitoring multi-class pesticide residues in fresh fruits and vegetables by liquid chromatography with tandem mass spectrometry[J]. J. Chromatogr A, 2004, 1048: 199-206
[32] M. J. Taylor, K. Hunter, K. B. Hunter, et al. Multi-residue method for rapid screening and confirmation of pesticides in crude extracts of fruits and vegetables using isocratic liquid chromatography with electrospray tandem mass spectrometry[J]. J. Chromatogr A, 2002, 982: 225-236
[33] D. Ortelli, P. Edder, C. Corvi. Multiresidue analysis of 74 pesticides in fruits and vegetables by liquid chromatography–electrospray–tandem mass spectrometry[J]. Anal. Chim. Acta, 2004, 520: 33-45
[34] C. Jansson, T. Pihlstr?m, B. G. ?sterdahl, et al. A new multi-residue method for analysis of pesticide residues in fruit and vegetables using liquid chromatography with tandem mass spectrometric detection[J]. J. Chromatogr A, 2004, 1023: 93-104
[35] S. J. Lehotay, A. de Kok, M. Hiemstra. Determination of streptomycin and dihydrostreptomycin in milk and honey by liquid chromatography with tandem mass spectrometry[J]. J. AOAC. Int, 2005, 88: 595
[36] G. . Alfredsson, C. Branzell, K. Granelli. Determination of chloramphenicol in animal tissues and urine: Liquid chromatography–tandem mass spectrometry versus gas chromatography–mass spectrometry. Analytica Chimica Acta, 2003, 483: 125-135
[37]余建新,胡小钟,余纯等. HPLC/ MS测定动物组织及尿样中的β-兴奋剂.分析测试技术与仪器, 2004, 10(4): 244-258
[38]林黎明,林回春,刘心同等.固相萃取高效液相色谱-质谱法测定动物组织中硝基呋喃代谢产物.分析化学, 2005, 33(5): 707-710
[39] A. Leitner, P. Zo¨llner, W. Lindner. Determination of the metabolites of nitrofuran antibiotics in animal tissue by high-performance liquid chromatography–tandem mass spectrometry. Journal of Chromatography A, 2001, 939: 49–58
[40] A. S. Pereira, L. C. Pampana, J. L. Donato, et al. Analysis of nitrofuran metabolicresidues in salt by liquid chromatography–tandem mass spectrometry. Analytica Chimica Acta, 2004, 514: 9–13
[41]蒋原,丁涛,沈崇钰等.液相色谱-电喷雾质谱联用检测蜂蜜中四种硝基呋喃类代谢物.畜牧与兽医, 2005, 37(3): 12-17
[42]丁涛,徐锦忠,沈崇钰等.高效液相色谱-串联质谱联用测定蜂王浆中的四种硝基呋喃类药物的代谢物.色谱, 2006, 24(5): 432-435
[43] J. A. Turton, A. C. Havard, S. Robinson, et al. Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse. Food and Chemical Toxicology, 2000, 38: 925-938.
[44]赵芸,余玲雁,余霞奎等.水产品中氟甲砜霉素的残留分析方法研究.浙江农业学报, 2004, 16 (4) : 218-220.
[45]谢文,丁慧瑛,章晓氡等.高效液相色谱串联质谱联用测定蜂蜜、蜂王浆中氯霉素残留.分析化学, 2005, 33(12): 1767-1770.
[46] G. Scortichini, L. Annunziata. , . M. N. Haouet, et al. Analytica Chimica Acta, 2005, 535 : 43-48.
[47] S. H. Yu, J. H. Liang. Screening, deter mination and confirmation of chloramphenicol in seafood, meat and honey using ELISA, HPLC-UVD, GC-ECD, GC-MS-EI-SIM and GCMS-NCI-SIM methods[J]. Analytica Chimica Acta, 2005, 535: 33-41
[48] A. F. Forti, G. Campana, A. Simonella, et al. Analytica Chimica Acta, 2005, 529 : 257-263
[49] I. Sandra, R. Wim, V. Jan, et al. Screening and confirmation of chloramphenicol in shrimp tissue using ELISA in combination with GC-MS2 and LC-MS2[J]. Analytica Chimica Acta, 2003, 483: 153-163
[50]杨方,陈国南.高效液相色谱法同时检测水产品中氯霉素,甲砜霉素与氟甲砜霉素残留[J].福建分析测试, 2005, 14(1): 2112-2113
[51]李鹏,邱月明,蔡慧霞等.气相色谱-质谱联用法测定动物组织中氯霉素、氟甲砜霉素和甲砜霉素的残留[J].色谱, 2005, 24(1): 14-18
[52] T. Nagata, H. Oka. Detection of Residual Chloramphenicol, Florfenicol and Thiamphenicol in Yellowtail Fish Muscles by Capillary Gas Chromatography-MassSpectrometry[J]. J. Agric. Food Chem, 1996, 44 (5): 1280-1284
[53]陈小霞,岳振峰,吉彩霓等.高效液相色谱-电喷雾电离三级四极杆质谱测定鸡肉中氯霉素,甲砜霉素和氟甲砜霉素的残留量[J].色谱, 2005, 23 (1): 92-95
[54] R. S. Nicolich, E. Werneck-Barroso, M. A. S. Marques. Food safety evaluation: Detection and confirmation of chloramphenicol in milk by high performance liquid chromatography-tandem mass spectrometry[J]. Analytica Chimica Acta, 2006, 565: 97-102
[54]彭涛,李淑娟,储晓刚等.高效液相色谱/串联质谱法同时测定虾中氯霉素、甲砜霉素和氟甲砜霉素残留量[J].分析化学, 2005, 33(4):463-466
[55]梅素容,王鹏,朱宽正等.用液相色谱-串联质谱测定蜂王浆中氯霉素残留量[J].华中科大学学报(自然科学版), 2006, 34(2): 115-117
[56] Kietzmann M. , Hapke H. J. , Beeke M. , Stehle S. Problems with malachite green use in fish[J]. Dtsch Tierarztl Wochenschr, 1990, 97, 290-293
[57] A. A. Bergwerff, R. V. Kuiper, P. Scherpenisse. High-performance liquid chromatographic determination of the triphenylmethane dye, malachite green, using amperometric detection at a carbon fibre microelectrode[J]. Aquaculture , 2004, 233: 55-59
[58]郭德华,叶长淋,朱莹洁.液相色谱法测定鳗鱼中的孔雀石绿[J].化学分析计量, 2002, 11(2): 20-23
[59] C. A. J. Hajee, N. Haagsma. Determination of malachite green and its metabolite, leucomalachite green, in catfish tissue by liquid chromatography with visible detection[J]. J. Chromatogr. B, 1995, 669 : 219
[60] L. G. Rushing, S. F. Webb, H. C. Thompson Jr. Determination of leucogentian violet and gentian violet in catfish tissue by high-performance liquid chromatography with visible detection[J]. J. Chromatogra. B, 1995, 674: 125.
[61] L. G. Rushing, H. C. Thompson Jr. Simultaneous determination of malachite green, gentian violet and their leuco metabolites in catfish or trout tissue by high-performance liquid chromatography with visible detection[J]. J. Chromatogr. B, 1997, 688: 325
[62] K. Mitrowska, A. Posyniak, J. Zmudzki. Determination of malachite green and leucomalachite green in carp muscle by liquid chromatography with visible and fluorescence detection[J]. J. Chromatogr. A, 2005, 1089: 187-182
[63] S. B, Turnipseed, J. E. Roybal, H. S. Rupp. Particle beam liquid chromatography– mass spectrometry of triphenylmethane dyes: application to confirmation of malachite green in catfish tissue[J]. J. Chromatogr B 1995, 670, 52–62
[64] L. Vallea, Cecilia . D, A L. Zanocco. Determination of the sum of malachite green and leucomalachite green in salmon muscle by liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry[J]. J Chromatogr A, 2005, 1067: 101-105
[65]郭德华,叶长淋,李波.高效液相色谱-质谱法测定水产品中孔雀石绿及其代谢物[J].分析测试报, 2004, 23(5): 206-208
[66] Aldert A. Bergwerff, P. Scherpenisse. Determination of residues of malachite green in aquatic animals[J]. J. Chromatogr. B, 2003, 788: 351
[67] P. Scherpenisse, A. A. Bergwerff. Determination of residues of malachite green in finfish by liquid chromatography tandem mass spectrometry[J]. Analytica Chimica Acta, 2005, 529: 173–177
[68]王鹏,朱宽正,梅素容等.液相色谱-串联质谱法快速测定水产品中结晶紫及其隐色代谢物残留[J].分析科学学报, 2006, 22(3): 283-286
[69] M. Dubois, D. Fluchard, E. Sior, P. Delahaut. Identification and quantification of five macrolide antibiotics in several tissues, eggs and milk by liquid chromatography–electrospray tandem mass spectrometry[J]. J. Chromatogr. B, 2001, 753: 189-202
[70] B. Toussaint, M. Chedin, G. Bordin, et al. Determination of (fluoro)quinolone antibiotic residues in pig kidney using liquid chromatography–tandem mass spectrometry I. Laboratory-validated method[J]. J. Chromatogr. A, 2005, 1088 : 32–39
[71]施冰,张志刚,吴抒怀等. LC/MS/MS测定水产品中7种氟喹诺酮类抗菌素残留量的方法研究[J].检验检疫科学, 2004, 14(9):25-30
[72] N. Van Hoof, K. De Wasch, L. Okerman, W. Reybroeck, et al. Validation of a liquid chromatography–tandem mass spectrometric method for the quantification of eight quinolones in bovine muscle, milk and aquacultured products[J]. Analytica Chimica Acta, 2005, 529: 265-272
[73] D. N. Heller, M. A. Ngoh, D. Donoghue, et al. Identification of incurred sulfonamide residues in eggs: methods for confirmation by liquid chromatography–tandem mass spectrometry and quantitation by liquid chromatography with ultraviolet detection[J]. J. Chromatogr. B, 2002, 774 : 39-52
[74]庞国芳,曹彦忠,张进杰等.液相色谱-串联质谱同时测定家禽组织中16种磺胺残留[J].分析化学研究报告, 2005, 33(9): 1252-1256
[75]秦燕,张美金,林海丹.高效液相色谱-电喷雾串联质谱法测定动物饲料中的10种磺胺[J].色谱, 2005, 23(4): 397-400
[76] Y. Ito, T. Goto, H. Oka, et al. Application of ion-exchange cartridge clean-up in food analysis: VI. Determination of six penicillins in bovine tissues by liquid chromatography–electrospray ionization tandem mass spectrometry[J]. J. Chromatogr. A, 2004, 1042: 107-111
[77] L. Mortier, E. Daeseleire, P. Delahaut. Simultaneous detection of five coccidiostats in eggs by liquid chromatography–tandem mass spectrometry[J]. Analytica Chimica Acta, 2003, 483: 27–37
[78]丁涛,徐锦忠,沈崇钰等.高效液相色谱-串联质谱联用测定蜂蜜中3种硝基咪唑类残留[J].分析化学, 2006, 34(8): 1206
[79]丁涛,徐锦忠,沈崇钰等.高效液相色谱-串联质谱联用测定蜂王浆中的三种硝基咪唑类残留[J].色谱, 2006, 24(4): 331-336
[80]杨成对,宋莉晖.家禽肌肉组织中硝基咪唑类药物残留的液相色谱串联质谱测定[J].分析测试学报, 2006, 25(4): 101-103
[81] H. Nakazawa, S. Ino, K. Kato, et al. Simultaneous determination of residual tetracyclines in foods by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry[J]. J. Chromatogr. B, 1999, 732: 55-64
[82] R. E. Hornish, J. R. Wiest. Quantitation of spectinomycin residues in bovine tissues by ion-exchange high-performance liquid chromatography with post-column derivatization and confirmation by reversed-phase high-performance liquid chromatography–atmospheric pressure chemical ionization tandem mass spectrometry[J]. J. Chromatography. A, 1998 , 812: 123-133
[83] D. N. Heller, S. B. Clark, H. F. Righter. Confirmation of gentamicin and neomycin in milk by weak cation-exchange extraction and electrospray ionization/ion trap tandem mass spectrometry[J]. J. Mass Spectrom. , 2000, 35: 39-45
[84] M. Bruijnsvoort, S. J. M. Ottink, K. M. Jonker, et al. Determination of streptomycin and dihydrostreptomycin in milk and honey by liquid chromatography with tandem mass spectrometry[J]. J. Chromatogr. A, 2004, 1058: 137-142
[85] D. W. Sin, Y. Wong, A. Chun-bong Ip. Quantitative analysis of lincomycin in animal tissues and bovine milk by liquid chromatography electrospray ionization tandem mass spectrometry[J]. J. Pharmaceutical and Biomedical Analysis, 2004, 34: 651-659
[86]余建新,胡小钟,林雁飞等.尿样及动物组织中甲氧苄氨嘧啶残留量的高效液相色谱-串联质谱测定法[J].分析测试学报, 2005 , 24 (3): 107-109
[87]A. Leitner, P. Z?llner, A. Paolillo, et al. Comparison of methods for the determination of ochratoxin A in wine[J]. Analytica Chimica Acta, 2002, 453: 33–41
[88] C. Cavaliere, G. D. Ascenzo, P. Foglia, et al. Determination of mycotoxins in bovine milk by liquid chromatography tandem mass spectrometry[J]. J. Chromatogr B, 2005, 820: 183-196
[89]刘承兰,许文娜, A. Kofoe等.液相色谱-电喷雾串联质谱法测定食品中的伏马菌素[J].分析化学, 2005, 33(11): 1619-1622
[90] C. Cavaliere, G. D’Ascenzo, P. Foglia, et al. Determination of type B trichothecenes and macrocyclic lactone mycotoxins in field contaminated maize[J]. Food Chemistry, 2005, 92: 559-568
[91] P. Z?llner, J. Jodlbauer, W. Lindner. Determination of zearalenone in grain s by high-performance liquid chromatography–tandem mass spectrometry after solid-phase extraction with RP-18 columns or immunoaffinity columns[J]. J. Chromatogr. A, 1999, 858: 167-174
[92] P. Z?llner, D. Berner, J. Jodlbauer et al. Determination of zearalenone and its metabolitesα- andβ-zearalenol in beer samples by high-performance liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr. B, 2000, 738: 233-241
[93] M. Lindenmeier, P. Schieberle, M. Rychlik. Quantification of ochratoxin A in foods by a stable isotope dilution assay using high-performance liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr. A, 2004, 1023: 57-66
[94] M. Reinsch, A. Topfer , A. Lehmann, et al. Determination of ochratoxin A in beer by LC–MS/MS ion trap detection[J]. Food Chemistry, 2007, 100: 312–317
[95] C. Cavaliere, P. Foglia, C. Guarino, et al. Aflatoxin M1 determination in cheese by liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr. A, 2006, 1135: 135-141
[96]C. Cavaliere, P. Foglia, E. Pastorini, R. Samperi. et al. Liquid chromatography/tandem mass spectrometric confirmatory method for determining aflatoxin M1 in cow milk: Comparison between electrospray and atmospheric pressure photoionization sources[J]. J. Chromatogr. A, 2006, 1101: 69-78
[97] D. Andrzejewski, J. A. G. Roach, L. MARTHA, et al. Analysis of Coffee for the Presence of Acrylamide by LC-MS/MS[J]. J. Agric. Food Chem, 2004, 52, 1996-2002
[98]刘红河,陈春晓,柳其芳等.高效液相色谱-串联质谱联用测定富含淀粉食品中丙烯酰胺[J].分析化学, 2006, 34(5): 235-238
[2]陶纯洁,朱燕平,王旭峰.食品安全现状及食品安全检测技术应用浅析[J].粮食与食品工业, 2006, 13(5): 14-17
[3] C. Soler, Y. Pico′. Recent trends in liquid chromatography tandem mass spectrometry to determine pesticides and their metabolites in food[J]. Trends in Analytical Chemistry, 2006
[4] European Commission, Commission Decision 2002/657/CE implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results[J], Off. J. Eur. Commun. L, 2002, 221: 8-17
[5]刘密新,杨成对.液相色谱-质谱仪的近期进展[J].分析测试学报, 2004, 23(10): 151-154
[6] D. Barcelo. LC–tandem MS[J]. Trends in Analytical Chemistry, 2005, 24: 564-565
[7] D. B. Robb, T. R. Covey, A. P. Bruins. Atmospheric Pressure Photoionization: An Ionization Method for Liquid Chromatography-Mass Spectrometry[J]. Anal Chem. 2000, 72: 3653-3659
[8] T. J. Kauppila, T. Kotiaho, R. Kostiainen. Negative Ion-Atmospheric Pressure Photoionization-Mass Spectrometry[J]. J Am Soc Mass Spectrom, 2004, 15: 203-211
[9] T. J. Kauppila, P. Ostman, S. Marttila, et al. Atmospheric Pressure Photoionization-Mass Spectrometry with a Microchip Heated Nebulizer[J]. Anal. Chem, 2004, 76: 6797-6801
[10] S. A. C. Wren. Simultaneous determination of malachite green, gentian violet and their leuco metabolites in catfish or trout tissue by highperformance liquid chromatography with ultravioletvisible detection[J]. J. Pharm. Biomed. Anal, 2005, 38: 337-340
[11] T. Kovalczuk, M. Jech, J. Poustka, et al. Ultra-performance liquid chromatography–tandem mass spectrometry: A novel challenge in multiresiduepesticide analysis in food[J]. Analytica Chimica Acta, 2006, 577: 8-17
[12] J. M. Marín, J. V. Sancho, O. J. Pozo, et al. Quantification and confirmation of anionic, cationic and neutral pesticides and transformation products in water by on-line solid phase extraction–liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr. A, 2006, 1133: 204-214
[13] C. Blasco, G. Font, J. Manes, et al. Solid-Phase Microextraction Liquid Chromatography/Tandem Mass Spectrometry ToDetermine Postharvest Fungicides in Fruits[J]. Anal. Chem, 2003, 75: 3606-3615
[14] T. Goto, Y. Ito, H. Oka, I. Saito, et al. The high throughput analysis of N-methyl carbamate pesticides in wine and juice by electrospray ionization liquid chromatography tandem mass spectrometry with direct sample injection into a short column[J]. Anal. Chim. Acta, 2005, 531: 79-86
[15]徐远金,李永库.液相色谱-电喷雾质谱联用法测定蔬菜中7种有机磷农药残留量.分析测试学报, 2006, 25(4): 36-40
[16] G. F. Pang, Y. Z. Cao, J. J. Zhang, et al. Validation study on 660 pesticide residues in animal tissues by gel permeation chromatography cleanup/gas chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr A, 2006, 1125: 1-30
[17] F. Hernández, O. J. Pozo, J. V. Sancho, et al. Multiresidue liquid chromatography tandem mass spectrometry determination of 52 non gas chromatography-amenable pesticides and metabolites in different food commodities[J]. J. Chromatogr A, 2006, 1109: 242-252
[18] E. M. Thurman, I. Ferrer, J. A. Zweigenbaum, et al. Discovering metabolites of post-harvest fungicides in citrus with liquid chromatography/time-of-flight mass spectrometry and ion trap tandem mass spectrometry[J]. J. Chromatogr A, 2005, 1082: 71-82
[19] J. F. G. Reyes, I. Ferrer, E. M. Thurman, et al. Rapid Commun[J]. Mass Spectrom. , 2005, 19: 2780
[20] B. A. Ingelse, R. C. J. van Dam, R. J. Vreeken, et al. Determination of polar organophosphorus pesticides in aqueous samples by direct injection using liquidchromatography–tandem mass spectrometry[J]. J. Chromatogr A, 2001, 918: 67-78
[21] H. G. J. Mol, R. C. J. Dam, O. M. Steijger. Determination of polar organophosphorus pesticides in vegetables and fruits using liquid chromatography with tandem mass spectrometry: selection of extraction solvent[J]. J. Chromatogr A, 2003, 1015: 119-127
[22] T. Goto, Y. Ito, S. Yamada, et al. The high throughput analysis of N-methyl carbamate pesticides in fruits and vegetables by liquid chromatography electrospray ionization tandem mass spectrometry using a short column[J]. Anal. Chim. . Acta, 2006, 555: 225-232
[23] S. Riediker, H. Obrist, N. Varga, et al. Determination of chlormequat and mepiquat in pear, tomato, and wheat flour using on-line solid-phase extraction (Prospekt) coupled with liquid chromatography–electrospray ionization tandem mass spectrometry[J]. J. Chromatogr A, 2002, 966: 15-23
[24] I. Ferrer, E. Thurman, J. Zweigenbaum.液相飞行时间质谱(LC /MSD TOF)和液相色谱/离子阱质谱(LC /MSD Trap)测定色拉蔬菜中的氯烟碱类杀虫剂[J].环境化学, 2005, 24(3): 349-354
[25]谢文,丁慧瑛,蒋晓英等.液相色谱-串联质谱检测蔬菜和茶叶中吡虫啉的残留量[J].色谱, 2006, 24(6): 633-635
[26] C. Blasco, G. Font , Y. Picó. Multiple-stage mass spectrometric analysis of six pesticides in oranges by liquid chromatography–atmospheric pressure chemical ionization–ion trap mass spectrometry[J]. J. Chromatogr A, 2004, 1043: 231-238
[27] T. Zamora, O. J. Pozo, F. J. López, et al. Determination of tridemorph and other fungicide residues in fruit samples by liquid chromatography–electrospray tandem mass spectrometry[J]. J. Chromatogr A, 2004, 1045: 137-143
[28] J. V. Sancho, M. Ibá?ez, S. Grimalt, et al. Residue determination of cyromazine and its metabolite melamine in chard samples by ion-pair liquid chromatography coupled to electrospray tandem mass spectrometry[J]. Anal. Chim. . Acta, 2005, 530: 237-243
[29] O. J. Pozo, J. M. Marin, J. V. Sancho, et al. Determination of abamectin and azadirachtin residues in orange samples by liquid chromatography–electrospray tandem mass spectrometry[J]. J. Chromatogr A, 2003, 992: 133-140
[30] C. Soler, B. Hamilton, A. Furey, et al. Optimization of LC–MS/MS using triple quadrupole mass analyzer for the simultaneous analysis of carbosulfan and its main metabolites in oranges[J]. Anal. Chim. . Acta, 2006, 571: 1-11
[31] A. G. Frenich, J. L. M. Vidal, T. López, et al. Monitoring multi-class pesticide residues in fresh fruits and vegetables by liquid chromatography with tandem mass spectrometry[J]. J. Chromatogr A, 2004, 1048: 199-206
[32] M. J. Taylor, K. Hunter, K. B. Hunter, et al. Multi-residue method for rapid screening and confirmation of pesticides in crude extracts of fruits and vegetables using isocratic liquid chromatography with electrospray tandem mass spectrometry[J]. J. Chromatogr A, 2002, 982: 225-236
[33] D. Ortelli, P. Edder, C. Corvi. Multiresidue analysis of 74 pesticides in fruits and vegetables by liquid chromatography–electrospray–tandem mass spectrometry[J]. Anal. Chim. Acta, 2004, 520: 33-45
[34] C. Jansson, T. Pihlstr?m, B. G. ?sterdahl, et al. A new multi-residue method for analysis of pesticide residues in fruit and vegetables using liquid chromatography with tandem mass spectrometric detection[J]. J. Chromatogr A, 2004, 1023: 93-104
[35] S. J. Lehotay, A. de Kok, M. Hiemstra. Determination of streptomycin and dihydrostreptomycin in milk and honey by liquid chromatography with tandem mass spectrometry[J]. J. AOAC. Int, 2005, 88: 595
[36] G. . Alfredsson, C. Branzell, K. Granelli. Determination of chloramphenicol in animal tissues and urine: Liquid chromatography–tandem mass spectrometry versus gas chromatography–mass spectrometry. Analytica Chimica Acta, 2003, 483: 125-135
[37]余建新,胡小钟,余纯等. HPLC/ MS测定动物组织及尿样中的β-兴奋剂.分析测试技术与仪器, 2004, 10(4): 244-258
[38]林黎明,林回春,刘心同等.固相萃取高效液相色谱-质谱法测定动物组织中硝基呋喃代谢产物.分析化学, 2005, 33(5): 707-710
[39] A. Leitner, P. Zo¨llner, W. Lindner. Determination of the metabolites of nitrofuran antibiotics in animal tissue by high-performance liquid chromatography–tandem mass spectrometry. Journal of Chromatography A, 2001, 939: 49–58
[40] A. S. Pereira, L. C. Pampana, J. L. Donato, et al. Analysis of nitrofuran metabolicresidues in salt by liquid chromatography–tandem mass spectrometry. Analytica Chimica Acta, 2004, 514: 9–13
[41]蒋原,丁涛,沈崇钰等.液相色谱-电喷雾质谱联用检测蜂蜜中四种硝基呋喃类代谢物.畜牧与兽医, 2005, 37(3): 12-17
[42]丁涛,徐锦忠,沈崇钰等.高效液相色谱-串联质谱联用测定蜂王浆中的四种硝基呋喃类药物的代谢物.色谱, 2006, 24(5): 432-435
[43] J. A. Turton, A. C. Havard, S. Robinson, et al. Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse. Food and Chemical Toxicology, 2000, 38: 925-938.
[44]赵芸,余玲雁,余霞奎等.水产品中氟甲砜霉素的残留分析方法研究.浙江农业学报, 2004, 16 (4) : 218-220.
[45]谢文,丁慧瑛,章晓氡等.高效液相色谱串联质谱联用测定蜂蜜、蜂王浆中氯霉素残留.分析化学, 2005, 33(12): 1767-1770.
[46] G. Scortichini, L. Annunziata. , . M. N. Haouet, et al. Analytica Chimica Acta, 2005, 535 : 43-48.
[47] S. H. Yu, J. H. Liang. Screening, deter mination and confirmation of chloramphenicol in seafood, meat and honey using ELISA, HPLC-UVD, GC-ECD, GC-MS-EI-SIM and GCMS-NCI-SIM methods[J]. Analytica Chimica Acta, 2005, 535: 33-41
[48] A. F. Forti, G. Campana, A. Simonella, et al. Analytica Chimica Acta, 2005, 529 : 257-263
[49] I. Sandra, R. Wim, V. Jan, et al. Screening and confirmation of chloramphenicol in shrimp tissue using ELISA in combination with GC-MS2 and LC-MS2[J]. Analytica Chimica Acta, 2003, 483: 153-163
[50]杨方,陈国南.高效液相色谱法同时检测水产品中氯霉素,甲砜霉素与氟甲砜霉素残留[J].福建分析测试, 2005, 14(1): 2112-2113
[51]李鹏,邱月明,蔡慧霞等.气相色谱-质谱联用法测定动物组织中氯霉素、氟甲砜霉素和甲砜霉素的残留[J].色谱, 2005, 24(1): 14-18
[52] T. Nagata, H. Oka. Detection of Residual Chloramphenicol, Florfenicol and Thiamphenicol in Yellowtail Fish Muscles by Capillary Gas Chromatography-MassSpectrometry[J]. J. Agric. Food Chem, 1996, 44 (5): 1280-1284
[53]陈小霞,岳振峰,吉彩霓等.高效液相色谱-电喷雾电离三级四极杆质谱测定鸡肉中氯霉素,甲砜霉素和氟甲砜霉素的残留量[J].色谱, 2005, 23 (1): 92-95
[54] R. S. Nicolich, E. Werneck-Barroso, M. A. S. Marques. Food safety evaluation: Detection and confirmation of chloramphenicol in milk by high performance liquid chromatography-tandem mass spectrometry[J]. Analytica Chimica Acta, 2006, 565: 97-102
[54]彭涛,李淑娟,储晓刚等.高效液相色谱/串联质谱法同时测定虾中氯霉素、甲砜霉素和氟甲砜霉素残留量[J].分析化学, 2005, 33(4):463-466
[55]梅素容,王鹏,朱宽正等.用液相色谱-串联质谱测定蜂王浆中氯霉素残留量[J].华中科大学学报(自然科学版), 2006, 34(2): 115-117
[56] Kietzmann M. , Hapke H. J. , Beeke M. , Stehle S. Problems with malachite green use in fish[J]. Dtsch Tierarztl Wochenschr, 1990, 97, 290-293
[57] A. A. Bergwerff, R. V. Kuiper, P. Scherpenisse. High-performance liquid chromatographic determination of the triphenylmethane dye, malachite green, using amperometric detection at a carbon fibre microelectrode[J]. Aquaculture , 2004, 233: 55-59
[58]郭德华,叶长淋,朱莹洁.液相色谱法测定鳗鱼中的孔雀石绿[J].化学分析计量, 2002, 11(2): 20-23
[59] C. A. J. Hajee, N. Haagsma. Determination of malachite green and its metabolite, leucomalachite green, in catfish tissue by liquid chromatography with visible detection[J]. J. Chromatogr. B, 1995, 669 : 219
[60] L. G. Rushing, S. F. Webb, H. C. Thompson Jr. Determination of leucogentian violet and gentian violet in catfish tissue by high-performance liquid chromatography with visible detection[J]. J. Chromatogra. B, 1995, 674: 125.
[61] L. G. Rushing, H. C. Thompson Jr. Simultaneous determination of malachite green, gentian violet and their leuco metabolites in catfish or trout tissue by high-performance liquid chromatography with visible detection[J]. J. Chromatogr. B, 1997, 688: 325
[62] K. Mitrowska, A. Posyniak, J. Zmudzki. Determination of malachite green and leucomalachite green in carp muscle by liquid chromatography with visible and fluorescence detection[J]. J. Chromatogr. A, 2005, 1089: 187-182
[63] S. B, Turnipseed, J. E. Roybal, H. S. Rupp. Particle beam liquid chromatography– mass spectrometry of triphenylmethane dyes: application to confirmation of malachite green in catfish tissue[J]. J. Chromatogr B 1995, 670, 52–62
[64] L. Vallea, Cecilia . D, A L. Zanocco. Determination of the sum of malachite green and leucomalachite green in salmon muscle by liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry[J]. J Chromatogr A, 2005, 1067: 101-105
[65]郭德华,叶长淋,李波.高效液相色谱-质谱法测定水产品中孔雀石绿及其代谢物[J].分析测试报, 2004, 23(5): 206-208
[66] Aldert A. Bergwerff, P. Scherpenisse. Determination of residues of malachite green in aquatic animals[J]. J. Chromatogr. B, 2003, 788: 351
[67] P. Scherpenisse, A. A. Bergwerff. Determination of residues of malachite green in finfish by liquid chromatography tandem mass spectrometry[J]. Analytica Chimica Acta, 2005, 529: 173–177
[68]王鹏,朱宽正,梅素容等.液相色谱-串联质谱法快速测定水产品中结晶紫及其隐色代谢物残留[J].分析科学学报, 2006, 22(3): 283-286
[69] M. Dubois, D. Fluchard, E. Sior, P. Delahaut. Identification and quantification of five macrolide antibiotics in several tissues, eggs and milk by liquid chromatography–electrospray tandem mass spectrometry[J]. J. Chromatogr. B, 2001, 753: 189-202
[70] B. Toussaint, M. Chedin, G. Bordin, et al. Determination of (fluoro)quinolone antibiotic residues in pig kidney using liquid chromatography–tandem mass spectrometry I. Laboratory-validated method[J]. J. Chromatogr. A, 2005, 1088 : 32–39
[71]施冰,张志刚,吴抒怀等. LC/MS/MS测定水产品中7种氟喹诺酮类抗菌素残留量的方法研究[J].检验检疫科学, 2004, 14(9):25-30
[72] N. Van Hoof, K. De Wasch, L. Okerman, W. Reybroeck, et al. Validation of a liquid chromatography–tandem mass spectrometric method for the quantification of eight quinolones in bovine muscle, milk and aquacultured products[J]. Analytica Chimica Acta, 2005, 529: 265-272
[73] D. N. Heller, M. A. Ngoh, D. Donoghue, et al. Identification of incurred sulfonamide residues in eggs: methods for confirmation by liquid chromatography–tandem mass spectrometry and quantitation by liquid chromatography with ultraviolet detection[J]. J. Chromatogr. B, 2002, 774 : 39-52
[74]庞国芳,曹彦忠,张进杰等.液相色谱-串联质谱同时测定家禽组织中16种磺胺残留[J].分析化学研究报告, 2005, 33(9): 1252-1256
[75]秦燕,张美金,林海丹.高效液相色谱-电喷雾串联质谱法测定动物饲料中的10种磺胺[J].色谱, 2005, 23(4): 397-400
[76] Y. Ito, T. Goto, H. Oka, et al. Application of ion-exchange cartridge clean-up in food analysis: VI. Determination of six penicillins in bovine tissues by liquid chromatography–electrospray ionization tandem mass spectrometry[J]. J. Chromatogr. A, 2004, 1042: 107-111
[77] L. Mortier, E. Daeseleire, P. Delahaut. Simultaneous detection of five coccidiostats in eggs by liquid chromatography–tandem mass spectrometry[J]. Analytica Chimica Acta, 2003, 483: 27–37
[78]丁涛,徐锦忠,沈崇钰等.高效液相色谱-串联质谱联用测定蜂蜜中3种硝基咪唑类残留[J].分析化学, 2006, 34(8): 1206
[79]丁涛,徐锦忠,沈崇钰等.高效液相色谱-串联质谱联用测定蜂王浆中的三种硝基咪唑类残留[J].色谱, 2006, 24(4): 331-336
[80]杨成对,宋莉晖.家禽肌肉组织中硝基咪唑类药物残留的液相色谱串联质谱测定[J].分析测试学报, 2006, 25(4): 101-103
[81] H. Nakazawa, S. Ino, K. Kato, et al. Simultaneous determination of residual tetracyclines in foods by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry[J]. J. Chromatogr. B, 1999, 732: 55-64
[82] R. E. Hornish, J. R. Wiest. Quantitation of spectinomycin residues in bovine tissues by ion-exchange high-performance liquid chromatography with post-column derivatization and confirmation by reversed-phase high-performance liquid chromatography–atmospheric pressure chemical ionization tandem mass spectrometry[J]. J. Chromatography. A, 1998 , 812: 123-133
[83] D. N. Heller, S. B. Clark, H. F. Righter. Confirmation of gentamicin and neomycin in milk by weak cation-exchange extraction and electrospray ionization/ion trap tandem mass spectrometry[J]. J. Mass Spectrom. , 2000, 35: 39-45
[84] M. Bruijnsvoort, S. J. M. Ottink, K. M. Jonker, et al. Determination of streptomycin and dihydrostreptomycin in milk and honey by liquid chromatography with tandem mass spectrometry[J]. J. Chromatogr. A, 2004, 1058: 137-142
[85] D. W. Sin, Y. Wong, A. Chun-bong Ip. Quantitative analysis of lincomycin in animal tissues and bovine milk by liquid chromatography electrospray ionization tandem mass spectrometry[J]. J. Pharmaceutical and Biomedical Analysis, 2004, 34: 651-659
[86]余建新,胡小钟,林雁飞等.尿样及动物组织中甲氧苄氨嘧啶残留量的高效液相色谱-串联质谱测定法[J].分析测试学报, 2005 , 24 (3): 107-109
[87]A. Leitner, P. Z?llner, A. Paolillo, et al. Comparison of methods for the determination of ochratoxin A in wine[J]. Analytica Chimica Acta, 2002, 453: 33–41
[88] C. Cavaliere, G. D. Ascenzo, P. Foglia, et al. Determination of mycotoxins in bovine milk by liquid chromatography tandem mass spectrometry[J]. J. Chromatogr B, 2005, 820: 183-196
[89]刘承兰,许文娜, A. Kofoe等.液相色谱-电喷雾串联质谱法测定食品中的伏马菌素[J].分析化学, 2005, 33(11): 1619-1622
[90] C. Cavaliere, G. D’Ascenzo, P. Foglia, et al. Determination of type B trichothecenes and macrocyclic lactone mycotoxins in field contaminated maize[J]. Food Chemistry, 2005, 92: 559-568
[91] P. Z?llner, J. Jodlbauer, W. Lindner. Determination of zearalenone in grain s by high-performance liquid chromatography–tandem mass spectrometry after solid-phase extraction with RP-18 columns or immunoaffinity columns[J]. J. Chromatogr. A, 1999, 858: 167-174
[92] P. Z?llner, D. Berner, J. Jodlbauer et al. Determination of zearalenone and its metabolitesα- andβ-zearalenol in beer samples by high-performance liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr. B, 2000, 738: 233-241
[93] M. Lindenmeier, P. Schieberle, M. Rychlik. Quantification of ochratoxin A in foods by a stable isotope dilution assay using high-performance liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr. A, 2004, 1023: 57-66
[94] M. Reinsch, A. Topfer , A. Lehmann, et al. Determination of ochratoxin A in beer by LC–MS/MS ion trap detection[J]. Food Chemistry, 2007, 100: 312–317
[95] C. Cavaliere, P. Foglia, C. Guarino, et al. Aflatoxin M1 determination in cheese by liquid chromatography–tandem mass spectrometry[J]. J. Chromatogr. A, 2006, 1135: 135-141
[96]C. Cavaliere, P. Foglia, E. Pastorini, R. Samperi. et al. Liquid chromatography/tandem mass spectrometric confirmatory method for determining aflatoxin M1 in cow milk: Comparison between electrospray and atmospheric pressure photoionization sources[J]. J. Chromatogr. A, 2006, 1101: 69-78
[97] D. Andrzejewski, J. A. G. Roach, L. MARTHA, et al. Analysis of Coffee for the Presence of Acrylamide by LC-MS/MS[J]. J. Agric. Food Chem, 2004, 52, 1996-2002
[98]刘红河,陈春晓,柳其芳等.高效液相色谱-串联质谱联用测定富含淀粉食品中丙烯酰胺[J].分析化学, 2006, 34(5): 235-238