司徒仪教授学术思想整理及针药结合治疗内异症痛经临床观察
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摘要
研究目的
阐述全国老中医药专家司徒仪教授的学术渊源,对司徒仪教授从事妇科临床工作40余年的经验进行总结,归纳整理司徒教授诊治子宫内膜异位症(EMT)的学术思想。司徒仪教授认为治疗妇科疾病“缓则图本,责之于肾；痛证血证癥瘕,重在祛瘀”,司徒教授应用治疗内异症痛经的经验方制成成药蒲田胶囊,治疗内异症痛经有效率85%,内异症痛经目前仍属临床难治之证,为探索治疗内异症痛经的新的有效途径,司徒教授尝试在临床上配合应用具有止痛优势、基本无痛的腹针治疗内异症痛经。此项研究是在司徒教授治疗妇科痛证“重在祛瘀”的学术思想指导下,观察针药结合即蒲田胶囊加腹针治疗子宫内膜异位症痛经的临床效果。
研究方法
采用非随机临床观察,选择子宫内膜异位症痛经病例70例,分为蒲田胶囊加腹针组(针药组)40例、田七痛经胶囊组(药物组)30例,通过视觉模拟法、痛经积分、McGill疼痛量表对研究组治疗前后痛经性质、程度、疼痛持续时间、妇科检查体征、盆腔B型超声检查等方面的变化进行自身前后、组间比较,评价针药组治疗子宫内膜异位症痛经的临床效果。
研究结果
司徒教授治疗妇科疾病的学术思想“缓则图本,责之于肾；痛证血证癥瘕,重在祛瘀”。在司徒教授治疗妇科痛证“重在祛瘀”的学术思想的指导下,开展针药结合即蒲田胶囊加腹针治疗子宫内膜异位症痛经的临床研究。临床研究结果如下：
1.两组患者经治疗后简化McGill量表评分均有下降,组内治疗前后比较,差异均有统计学意义(P<0.05),而组间比较,治疗前后差异亦有统计学意义(P<0.05),表明蒲田胶囊加腹针对内异症所致痛经的镇痛疗效优于药物组。
2.两组患者经治疗后痛经积分均有下降,组内治疗前后比较,差异均有统计学意义(P<0.05),而组间比较,治疗前后差异亦有统计学意义(P<0.05),表明蒲田胶囊加腹针对痛经积分的影响大于药物组。
3.两组患者不同中医证型治疗后疼痛评分及痛经积分均有下降,其中研究组中不同证型间两两比较,又以气滞血瘀型,肾虚血瘀型治疗后痛经评分显著优于另外两个证型(P<0.05)。表明蒲田胶囊加腹针疗法对气滞血瘀型,肾虚血瘀型尤为有效。
4.两组患者经治疗后CA125水平均有下降,组内治疗前后比较,差异均有统计学意义(P<0.05),而组间比较,治疗前后差异亦有统计学意义(P<0.05),表明蒲田胶囊加腹针治疗对CA125水平下降的影响大于药物组。
5.两组患者经治疗后月经情况均有改善,组间比较差异有统计学意义(P<0.05)。研究组月经情况的改善显著优于对照组(P<0.05)。表明蒲田胶囊加腹针疗法对内异症痛经合并有月经异常者效果更为理想。
创新观点
首次在司徒教授治疗妇科痛证“重在祛瘀”的学术思想指导下,应用蒲田胶囊加腹针治疗子宫内膜异位症痛经,并取得疗效。为内异症痛经这一临床顽症探索了新的治疗途径。
结论
在司徒仪教授诊治子宫内膜异位症的学术思想影响下,应用蒲田胶囊加腹针的方法,治疗子宫内膜异位症痛经效果显著,治疗后研究组简化McGill量表评分、痛经积分均有显著下降,经不同证型间两两比较,又以气滞血瘀型,肾虚血瘀型治疗后痛经评分下降更为明显。对合并月经失调患者能显著改善月经情况,同时降低CA125水平。另外通过安全性指标观察及不良反应观察,提示蒲田胶囊加腹针疗法具有较好的安全性及依从性。值得临床推广应用。
Objective
After we collated the ideology and experience of professor Si Tuyi for endometriosis, we found that the ideology of professor Si Tu for treating disease of gynecology was that the primary cause of disease in treatment is Kidney, at the same time she indicated that promoting blood circulation by removing blood Stasis was the most important for treating the pain of gynecology.
Prosser Si Tuyi concluded an effective therapeutic medicine—Pu Tian Capsule (PTC) which has been proved to have satisfying therapeutic effect on endometriosis patients. It's a new way to treat dysmenorrhea of endometriosis, so we made a study to used the Pu Tian Capsule and the abdominal acupuncture in patients with dysmenorrhea of endometriosis.
Methods
The70cases of endometriosis collected from September,2008to July,2011in Guangdong Province Chinese medicine hospital gynecology department outpatient service. All of them were puzzled by the dysmenorrhea associated with endometriosis. They divided into the treated group with40cases and the control group with30cases. The treated group took the Pu Tian Capsule and gived the treatment of abdominal acupuncture, while the control group only took the TianQi Capsule. Before and after the treatments we leted the patients write the short-form McGill pain questionnaire, table of integrals with dysmenorrhea, tset the blood serum level of CA125and EmAb, take the B-type ultrasonography and the woman examination, in order to record their cases of pelvic and the menstruation situation, in addition to carried on some secure target inspections. At last we distinction comparative analysised various targets between two group and own around in one group.
Result
1. After the treatments, both two groups had the drop in the grading of the short-form McGill pain questionnaire. There is statistics significance difference in the group own comparison (P<0.05). While the groups comparison also has statistics significance difference (P<0.05). The treated group is better than the control group in this aspect.
2. After the treatments, both two groups had the drop of table of integrals with dysmenorrhea. There is statistics significance difference in the group own comparison (P<0.05). While the groups comparison also has statistics significance difference (P<0.05). The treated group is better than the control group in this aspect.
3. In the treated group, all of the card typethe had changes in the grading of the short-form McGill pain questionnaire and table of integrals with dysmenorrhea, deficiency of kidney and blood stasis is best.
4. After the treatments, both two groups had the drop of the blood serum level of CA125. There is statistics significance difference in the group own comparison (P<0.05). While the groups comparison also has statistics significance difference (P<0.05). The treated group is better than the control group in this aspect.
5. both two groups had changes of menstruation, but the treated group is better than the control group.
Innovation
Under the ideology of professor Si Tuyi that promoting blood circulation by removing blood stasis was the most important for treating the pain of gynecology, we firstly used the Pu Tian Capsule and the abdominal acupuncture in patients with dysmenorrhea of endometriosis and we found thses were new way to treat dysmenorrhea of endometriosis.
Conclution
The Pu Tian Capsule and the abdominal acupuncture can relieve dysmenorrhea the associated with endometriosis effectively, obviously lower the blood serum level of CA125, change the menstruation. In all of the card typethe, deficiency of kidney and blood stasis is the best in these aspects. These suggest that the Pu Tian Capsule and the abdominal acupuncture can reduce the dystopia internal membrane activeness, improve its infiltration depth, even wither the dystopia internal membrane. The Pu Tian Capsule and the abdominal acupuncture also have good security and compliance.
阐述全国老中医药专家司徒仪教授的学术渊源,对司徒仪教授从事妇科临床工作40余年的经验进行总结,归纳整理司徒教授诊治子宫内膜异位症(EMT)的学术思想。司徒仪教授认为治疗妇科疾病“缓则图本,责之于肾；痛证血证癥瘕,重在祛瘀”,司徒教授应用治疗内异症痛经的经验方制成成药蒲田胶囊,治疗内异症痛经有效率85%,内异症痛经目前仍属临床难治之证,为探索治疗内异症痛经的新的有效途径,司徒教授尝试在临床上配合应用具有止痛优势、基本无痛的腹针治疗内异症痛经。此项研究是在司徒教授治疗妇科痛证“重在祛瘀”的学术思想指导下,观察针药结合即蒲田胶囊加腹针治疗子宫内膜异位症痛经的临床效果。
研究方法
采用非随机临床观察,选择子宫内膜异位症痛经病例70例,分为蒲田胶囊加腹针组(针药组)40例、田七痛经胶囊组(药物组)30例,通过视觉模拟法、痛经积分、McGill疼痛量表对研究组治疗前后痛经性质、程度、疼痛持续时间、妇科检查体征、盆腔B型超声检查等方面的变化进行自身前后、组间比较,评价针药组治疗子宫内膜异位症痛经的临床效果。
研究结果
司徒教授治疗妇科疾病的学术思想“缓则图本,责之于肾；痛证血证癥瘕,重在祛瘀”。在司徒教授治疗妇科痛证“重在祛瘀”的学术思想的指导下,开展针药结合即蒲田胶囊加腹针治疗子宫内膜异位症痛经的临床研究。临床研究结果如下：
1.两组患者经治疗后简化McGill量表评分均有下降,组内治疗前后比较,差异均有统计学意义(P<0.05),而组间比较,治疗前后差异亦有统计学意义(P<0.05),表明蒲田胶囊加腹针对内异症所致痛经的镇痛疗效优于药物组。
2.两组患者经治疗后痛经积分均有下降,组内治疗前后比较,差异均有统计学意义(P<0.05),而组间比较,治疗前后差异亦有统计学意义(P<0.05),表明蒲田胶囊加腹针对痛经积分的影响大于药物组。
3.两组患者不同中医证型治疗后疼痛评分及痛经积分均有下降,其中研究组中不同证型间两两比较,又以气滞血瘀型,肾虚血瘀型治疗后痛经评分显著优于另外两个证型(P<0.05)。表明蒲田胶囊加腹针疗法对气滞血瘀型,肾虚血瘀型尤为有效。
4.两组患者经治疗后CA125水平均有下降,组内治疗前后比较,差异均有统计学意义(P<0.05),而组间比较,治疗前后差异亦有统计学意义(P<0.05),表明蒲田胶囊加腹针治疗对CA125水平下降的影响大于药物组。
5.两组患者经治疗后月经情况均有改善,组间比较差异有统计学意义(P<0.05)。研究组月经情况的改善显著优于对照组(P<0.05)。表明蒲田胶囊加腹针疗法对内异症痛经合并有月经异常者效果更为理想。
创新观点
首次在司徒教授治疗妇科痛证“重在祛瘀”的学术思想指导下,应用蒲田胶囊加腹针治疗子宫内膜异位症痛经,并取得疗效。为内异症痛经这一临床顽症探索了新的治疗途径。
结论
在司徒仪教授诊治子宫内膜异位症的学术思想影响下,应用蒲田胶囊加腹针的方法,治疗子宫内膜异位症痛经效果显著,治疗后研究组简化McGill量表评分、痛经积分均有显著下降,经不同证型间两两比较,又以气滞血瘀型,肾虚血瘀型治疗后痛经评分下降更为明显。对合并月经失调患者能显著改善月经情况,同时降低CA125水平。另外通过安全性指标观察及不良反应观察,提示蒲田胶囊加腹针疗法具有较好的安全性及依从性。值得临床推广应用。
Objective
After we collated the ideology and experience of professor Si Tuyi for endometriosis, we found that the ideology of professor Si Tu for treating disease of gynecology was that the primary cause of disease in treatment is Kidney, at the same time she indicated that promoting blood circulation by removing blood Stasis was the most important for treating the pain of gynecology.
Prosser Si Tuyi concluded an effective therapeutic medicine—Pu Tian Capsule (PTC) which has been proved to have satisfying therapeutic effect on endometriosis patients. It's a new way to treat dysmenorrhea of endometriosis, so we made a study to used the Pu Tian Capsule and the abdominal acupuncture in patients with dysmenorrhea of endometriosis.
Methods
The70cases of endometriosis collected from September,2008to July,2011in Guangdong Province Chinese medicine hospital gynecology department outpatient service. All of them were puzzled by the dysmenorrhea associated with endometriosis. They divided into the treated group with40cases and the control group with30cases. The treated group took the Pu Tian Capsule and gived the treatment of abdominal acupuncture, while the control group only took the TianQi Capsule. Before and after the treatments we leted the patients write the short-form McGill pain questionnaire, table of integrals with dysmenorrhea, tset the blood serum level of CA125and EmAb, take the B-type ultrasonography and the woman examination, in order to record their cases of pelvic and the menstruation situation, in addition to carried on some secure target inspections. At last we distinction comparative analysised various targets between two group and own around in one group.
Result
1. After the treatments, both two groups had the drop in the grading of the short-form McGill pain questionnaire. There is statistics significance difference in the group own comparison (P<0.05). While the groups comparison also has statistics significance difference (P<0.05). The treated group is better than the control group in this aspect.
2. After the treatments, both two groups had the drop of table of integrals with dysmenorrhea. There is statistics significance difference in the group own comparison (P<0.05). While the groups comparison also has statistics significance difference (P<0.05). The treated group is better than the control group in this aspect.
3. In the treated group, all of the card typethe had changes in the grading of the short-form McGill pain questionnaire and table of integrals with dysmenorrhea, deficiency of kidney and blood stasis is best.
4. After the treatments, both two groups had the drop of the blood serum level of CA125. There is statistics significance difference in the group own comparison (P<0.05). While the groups comparison also has statistics significance difference (P<0.05). The treated group is better than the control group in this aspect.
5. both two groups had changes of menstruation, but the treated group is better than the control group.
Innovation
Under the ideology of professor Si Tuyi that promoting blood circulation by removing blood stasis was the most important for treating the pain of gynecology, we firstly used the Pu Tian Capsule and the abdominal acupuncture in patients with dysmenorrhea of endometriosis and we found thses were new way to treat dysmenorrhea of endometriosis.
Conclution
The Pu Tian Capsule and the abdominal acupuncture can relieve dysmenorrhea the associated with endometriosis effectively, obviously lower the blood serum level of CA125, change the menstruation. In all of the card typethe, deficiency of kidney and blood stasis is the best in these aspects. These suggest that the Pu Tian Capsule and the abdominal acupuncture can reduce the dystopia internal membrane activeness, improve its infiltration depth, even wither the dystopia internal membrane. The Pu Tian Capsule and the abdominal acupuncture also have good security and compliance.
引文
[1]向东方,司徒仪.耳穴埋针治疗子宫内膜异位症痛经58例临床观察.中医杂志,2001;
[2]冷金花,郎景和.子宫内膜异位症患者疼痛与盆腔病灶解剖分布的关系.中华妇产科杂志,2007;42(3)：165-168.
[3]张丽,崔恒.子宫内膜异位症所致慢性疼痛的相关研究.中国妇产科临床杂志,1997,8(5)：384-386
[4]刘媛媛,艾宙,美玉凤等.不同针灸方法治疗子宫内膜异位症痛经的疗效观察.湖北中医杂志,2009,31(7)：53-54
[5]陈慧.免煎血竭化瘀颗粒治疗痛经型子宫内膜异位症33例观察.浙江中医杂志,2008,43(6)：343-345
[6]王清,赵红,杨航等.“益坤内异丸”治疗子宫内膜异位症、子宫腺肌瘤痛经(血瘀肾虚证)的临床观察.中日友好医院学报,2009,23(4)：223-224
[7]边文会、杜惠兰,陈惠娟等.补肾化瘀法治疗子宫内膜异位症的临床研究.中国全科医学,2009,12(4B)：695-697
[8]杨春波,陈怡,金杭美等.香棱丸对子宫内膜异位症患者痛经和血清CA125的影响,中国中药杂志,2008,33(5)：567-568：
[9]孙占玲,金来蓓.耳针治疗子宫内膜异位症致痛经32例疗效观察.浙江中西医结合杂志,2007,17(12)：738-739
[10]邱丽,许志范,彭小鹏.通瘀煎加减合西药治疗子宫内膜异位症痛经51例.江西中医,
[11]林秀华.腹针配合灸法治疗寒凝型痛经疗效观察.山西中医,2008,24(3)：30-31,
[12]陆智义.内异止痛方对复发性子宫内膜异位症盆腔疼痛镇痛作用的疗效观察.时珍国医国药,2004,15(2)：108
[13]卢燕.克痛胶囊治疗子宫内膜异位症的临床研究.黑龙江中医药大学,2003年硕士论文
[14]李晓燕综述,冷金花审校.子宫内膜疼痛研究进展和治疗策略.国际妇产科学杂志2009,36(3)：225-227
[15]Chopin N,Vicira M,Borghese B, et al.Operative management of deeply infiltrating pelvic endometriosis:results on pelvic pain symptoms according to a surgical classification[J]. J Minim Invasive Gynecol,2005,12(2):106-112.
[16]Lieng M, Qvigstad E, Istre 0, et al. Long-term outcomes following laparoscopic supracervical ysterectomy[J]. BJOG,2008,115(13):1605-1610,
[17]Johuson NP, Farguhar CM, Crossleys,et al. Adouble-blind rando missed controlled trial of laparoscop, tutrine nerve ablation for women with chronic pelvic pain[J]BJOG 2004,111(9):950-959
[18]薄智云,牛庆强,朱文罡等.腹针治疗神经根型颈椎病的多中心随机对照临床研究.中国针灸,2005,25(6)：387—389
[19]郭元琦,陈丽仪,符文彬等.腹针治疗颈型颈椎病63例观察.中医药学刊,2005,23(3)：539-540
[20]薛由仁.腹针治疗椎动脉型颈椎病疗效观察.上海针灸杂志,2006,25(1)：14—15
[21]孔畅,黄刚,李永建.骶管封闭结合腹针治疗腰椎间盘突出症术后残余痛的疗效观察.山西中医,2006,22(3)：37—38
[22]杨水凤.腹针结合体针治疗偏头痛40例.辽宁中医学院学报,2006,8(1)：75
[23]李黄彤,黄泳.用简化McGill量表评定薄氏腹针对头、身、肢体疼痛的影响.中国全科医学,2005,8(18)：1540—1541
[24]高连印,刘小艳.腹针调神理气健脾化痰法治疗抑郁症30例的临床观察.北京中医,2006,25(3)：174—175
[25]王小云,杨红艳,孙艳梅等.薄氏腹针改善失眠症的随机对照研究.首届腹针国际学术研讨会,2005年,广州
[26]向东方,梁雪芳,陈秀华,薄氏腹针治疗慢性盆腔疼痛48例临床观察,陕西中医,2008,3：337
[27]向东方,孙巧璋,梁雪芳.薄氏腹针对子宫内膜异位症盆腔疼痛患者生存质量影响的临床观察.辽宁中医杂志,2010,5：861-862
[28]张振鄂,翟建平,姜惠中.子宫内膜异位症痛经患者血浆PGF2 α, PGE2变化及活血祛瘀法治疗机理探讨.中医杂志,2000,41(9)：559-560
[29]霍国敏,李淑萍,薛茜等.针刺联合中药汤剂对EMT镇痛机制的影响.中华临床医学研究杂志.2006,12(15)：1999-2000。
[30]黄健玲,司徒仪,程兰等。蒲田胶囊治疗子宫内膜异位症的临床疗效广州中医药大学学报2000,17(1)：40-41
[31]黄健玲,程兰,区勇全等。蒲田胶囊止痛止血作用的实验研究,中国现代医学杂志,2002,12(2) ： 48-49
[32]薄智云主编《腹针疗法》,中国科技出版社,1999.10
[33]于竹芳,毛沛,宁廷禄.硫酸吗啡控释片直肠给药控制癌痛疗效观察.临床肿瘤学杂志,2002,7(2)：121一123.
[34]雷桂华.酒石酸二氢可待因控释片治疗癌痛22例疗效观察.中国药师,2001,4(6)：478
[35]李黄彤,黄泳.用简化McGill量表评定薄氏腹针对头、身、肢体疼痛的影响.中国全科医学,2005,8(18)：1540—1541
[36]中华人民共和国卫生部.中药新药临床研究指导原则(第一辑),1993,263—-266
[37]朱小凤,蒋凤艳.血清CA125、EmAb与子宫内膜异位症痛经的关系.西部医学,2007；19(5)：873—874.
[38]石一复.子宫内膜异位症[M].上海：上海科学技术出版社,2002,16—24.
[39]Somigliana E, Vigano P, Tirelli AS, etal. Use of the concomitantserum dosage of CA125, CA19-9 and interleukin-6 to detect the presence of endometriosis. Hum Reprod,2004; 19 (8):1871-1876.
[2]冷金花,郎景和.子宫内膜异位症患者疼痛与盆腔病灶解剖分布的关系.中华妇产科杂志,2007;42(3)：165-168.
[3]张丽,崔恒.子宫内膜异位症所致慢性疼痛的相关研究.中国妇产科临床杂志,1997,8(5)：384-386
[4]刘媛媛,艾宙,美玉凤等.不同针灸方法治疗子宫内膜异位症痛经的疗效观察.湖北中医杂志,2009,31(7)：53-54
[5]陈慧.免煎血竭化瘀颗粒治疗痛经型子宫内膜异位症33例观察.浙江中医杂志,2008,43(6)：343-345
[6]王清,赵红,杨航等.“益坤内异丸”治疗子宫内膜异位症、子宫腺肌瘤痛经(血瘀肾虚证)的临床观察.中日友好医院学报,2009,23(4)：223-224
[7]边文会、杜惠兰,陈惠娟等.补肾化瘀法治疗子宫内膜异位症的临床研究.中国全科医学,2009,12(4B)：695-697
[8]杨春波,陈怡,金杭美等.香棱丸对子宫内膜异位症患者痛经和血清CA125的影响,中国中药杂志,2008,33(5)：567-568：
[9]孙占玲,金来蓓.耳针治疗子宫内膜异位症致痛经32例疗效观察.浙江中西医结合杂志,2007,17(12)：738-739
[10]邱丽,许志范,彭小鹏.通瘀煎加减合西药治疗子宫内膜异位症痛经51例.江西中医,
[11]林秀华.腹针配合灸法治疗寒凝型痛经疗效观察.山西中医,2008,24(3)：30-31,
[12]陆智义.内异止痛方对复发性子宫内膜异位症盆腔疼痛镇痛作用的疗效观察.时珍国医国药,2004,15(2)：108
[13]卢燕.克痛胶囊治疗子宫内膜异位症的临床研究.黑龙江中医药大学,2003年硕士论文
[14]李晓燕综述,冷金花审校.子宫内膜疼痛研究进展和治疗策略.国际妇产科学杂志2009,36(3)：225-227
[15]Chopin N,Vicira M,Borghese B, et al.Operative management of deeply infiltrating pelvic endometriosis:results on pelvic pain symptoms according to a surgical classification[J]. J Minim Invasive Gynecol,2005,12(2):106-112.
[16]Lieng M, Qvigstad E, Istre 0, et al. Long-term outcomes following laparoscopic supracervical ysterectomy[J]. BJOG,2008,115(13):1605-1610,
[17]Johuson NP, Farguhar CM, Crossleys,et al. Adouble-blind rando missed controlled trial of laparoscop, tutrine nerve ablation for women with chronic pelvic pain[J]BJOG 2004,111(9):950-959
[18]薄智云,牛庆强,朱文罡等.腹针治疗神经根型颈椎病的多中心随机对照临床研究.中国针灸,2005,25(6)：387—389
[19]郭元琦,陈丽仪,符文彬等.腹针治疗颈型颈椎病63例观察.中医药学刊,2005,23(3)：539-540
[20]薛由仁.腹针治疗椎动脉型颈椎病疗效观察.上海针灸杂志,2006,25(1)：14—15
[21]孔畅,黄刚,李永建.骶管封闭结合腹针治疗腰椎间盘突出症术后残余痛的疗效观察.山西中医,2006,22(3)：37—38
[22]杨水凤.腹针结合体针治疗偏头痛40例.辽宁中医学院学报,2006,8(1)：75
[23]李黄彤,黄泳.用简化McGill量表评定薄氏腹针对头、身、肢体疼痛的影响.中国全科医学,2005,8(18)：1540—1541
[24]高连印,刘小艳.腹针调神理气健脾化痰法治疗抑郁症30例的临床观察.北京中医,2006,25(3)：174—175
[25]王小云,杨红艳,孙艳梅等.薄氏腹针改善失眠症的随机对照研究.首届腹针国际学术研讨会,2005年,广州
[26]向东方,梁雪芳,陈秀华,薄氏腹针治疗慢性盆腔疼痛48例临床观察,陕西中医,2008,3：337
[27]向东方,孙巧璋,梁雪芳.薄氏腹针对子宫内膜异位症盆腔疼痛患者生存质量影响的临床观察.辽宁中医杂志,2010,5：861-862
[28]张振鄂,翟建平,姜惠中.子宫内膜异位症痛经患者血浆PGF2 α, PGE2变化及活血祛瘀法治疗机理探讨.中医杂志,2000,41(9)：559-560
[29]霍国敏,李淑萍,薛茜等.针刺联合中药汤剂对EMT镇痛机制的影响.中华临床医学研究杂志.2006,12(15)：1999-2000。
[30]黄健玲,司徒仪,程兰等。蒲田胶囊治疗子宫内膜异位症的临床疗效广州中医药大学学报2000,17(1)：40-41
[31]黄健玲,程兰,区勇全等。蒲田胶囊止痛止血作用的实验研究,中国现代医学杂志,2002,12(2) ： 48-49
[32]薄智云主编《腹针疗法》,中国科技出版社,1999.10
[33]于竹芳,毛沛,宁廷禄.硫酸吗啡控释片直肠给药控制癌痛疗效观察.临床肿瘤学杂志,2002,7(2)：121一123.
[34]雷桂华.酒石酸二氢可待因控释片治疗癌痛22例疗效观察.中国药师,2001,4(6)：478
[35]李黄彤,黄泳.用简化McGill量表评定薄氏腹针对头、身、肢体疼痛的影响.中国全科医学,2005,8(18)：1540—1541
[36]中华人民共和国卫生部.中药新药临床研究指导原则(第一辑),1993,263—-266
[37]朱小凤,蒋凤艳.血清CA125、EmAb与子宫内膜异位症痛经的关系.西部医学,2007；19(5)：873—874.
[38]石一复.子宫内膜异位症[M].上海：上海科学技术出版社,2002,16—24.
[39]Somigliana E, Vigano P, Tirelli AS, etal. Use of the concomitantserum dosage of CA125, CA19-9 and interleukin-6 to detect the presence of endometriosis. Hum Reprod,2004; 19 (8):1871-1876.