冠心病心绞痛平板运动试验阳性患者的中医证候特点研究
详细信息    本馆镜像全文|  推荐本文 |  |   获取CNKI官网全文
摘要
背景
     冠心病是冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)的简称,亦称为缺血性心脏病,既包括冠状动脉粥样硬化使管腔狭窄或闭塞导致心肌缺血缺氧而引起的心脏病,也包括冠状动脉功能性改变(痉挛),临床表现为心绞痛、心肌梗死、心律失常、心力衰竭等多种形式。根据临床表现,冠心病属于中医“胸痹”、“心痛”、“真心痛”等病范畴。近年来,成用西医辨病、中医辨证、病证结合的模式,对冠心病中医证候进行了大量的研究,取得了一定的进展,但对平板运动试验与中医证候间的相关性研究较少。
     目的
     本研究通过对临床诊断为冠心病心绞痛且平板运动试验阳性患者中医证候的判别,探索冠心病平板运动阳性患者的中医证候特征表现及其规律,并分析各种中医证型与冠心病患者运动耐量降低的相关性,从而为进一步提高临床辩证治疗冠心病运动耐量异常患者的疗效,并推动冠心病证候客观化研究及中医药防治冠心病心绞痛运动耐量异常的研究。
     方法
     纳入广东省中医院心脏中心2008年4月2009年4月临床诊断症状诊断为冠心病心绞痛且平板运动试验结果阳性的病人54例。由经过培训的人员,在对患者行运动平板试验后两小时后,48小时内,收集患者中医四诊信息和其他病情资料,填写病例观察表,进行数据整理及统计分析。
     结果
     1.54例患者中医证候分布规律为:寒凝证占42.6%,气滞证占44.4%,痰浊证63%,瘀血证占87.0%,心气不足证占75.9%,心阴不足证占29.6%,心阳不振证占59.3%。
     2.54例患者中医症尖较为集中的有胸闷,胸痛,乏力,舌质紫暗,舌质淡白,舌苔厚,舌苔腻,脉滑。
     结论
     54例临床诊断为冠心病心绞痛并平板运动实验阳性的患者冠心病中医证候中,以血瘀证47例(87.0%),心气不足证41例(75.9%),痰浊证34例(63.0%)最为常见。由多到少排列为:血瘀证>心气不足证)痰浊证>心阳不振证>气滞证>寒凝证>心阴不足证。结果与既往对胸痹心痛的症候调查的结果相似,不同的是,平板运动阳性患者血瘀,气虚的比例较以往的结果更大,提示运动耐量的异常跟气虚血瘀有更为重要的关系。
Background
     Coronary heart disease is a frequently-occurring diseases,the morbidity and mortality among the first.The current Western focus on prevention and treatment medication,interventional therapy,surgical treatment,and achieved significant therapeutic effect,making more and more patients to bertefit.However,side effects of long-term medication,and revascularization at the same time reducing the mortality rate,but the incidence of complications remains high,the status of traditional Chinese and western medicine for the treatment of coronary heart disease study offers a wjde range of prospects.Chinese medicine treatment of diseases of great importance to the dialectic,however,the lack of dialectical norms of governance,therefore, regulate the use of modern science and technology,modernization of traditional Chinese medicine Chinese medicine symptoms become the focus of the study.The broad masses of medical workers to use physical examination, laboratory examination of the signs of traditional Chinese medicine have been extensively studied,and acbieved remarkable results.Treadmill with the reliability of the diagnosis of coronary heart disease,as symptoms are the feasibility study of Chinese medicine,research in this area is currently less subject to the evaluation of coronary heart disease through the treadmill of Chinese medicine-based distribution of symptoms,signs for the Chinese medicine research to lay the foundation.
     Objective
     In this study,the clinical diagnosis of angina pectoris and positive treadmill exercise in patients with the identification of TCM Syndrome,and explore positive treadmill exercise in patients with coronary heart disease in Chinese medicine and the law of symptom characterized by and analysis of TCM syndrome in patients with coronary heart disease reduced exercise tolerance of the correlation,so as to further enhance the Clinical Diagnosis and Treatment of coronary heart disease in patients with abnormal exercise tolerance efficacy,and to promote further objective evidence of coronary heart disease and angina p(?)(?)toris in Chinese medicine to combat abnormal exercise tolerance studies.
     Methods
     Into the Guangdong Provincial TCM Hospital Heart Center in April 2008-2009 clinical diagnosis in April was diagnosed with symptoms of angina pectoris and positive treadmill exercise test results of 54 cases of patients,By trained personnel,patients in the treadmill for two hours after the experiment, the 48 hours to collect four diagnostic information in patients with Chinese medicine and other disease information,fill out the form observed cases,data collation and statistical analysis.
     Results
     54 cases of Chinese medicine syndromes in patients with distribution as follows:blood cards accounted for 87.0%,heart card gas account for less than 75.9%,63.0%phlegm card,heart card yang weak 59.3%,42.6%card,gas accounted for 44.4%of stagnation heart.yam 29.6%less than evidence.
     Conclusion
     Clinical diagnosis of 54 cases of angina pectoris and positive treadmill exercise test in patients with coronary heart disease syndromes in traditional Chinese medicine,blood stasis in 47 cases(87.0%),heart certified 41 cases of gas shortage(79.5%),34 cases of phlegm card(63.0%) most common.By decreasing order as follows:Blood Stasis>Heart insufficient gas card> phlegm cardgt;Yang weak heart cardgt;Qi stagnation;card;Heart Yin insufficient evidence.The results of previous symptoms of chest pain similar to the findings of the survey,difference is that the treadmill exercise in patients with positive blood stasis,qi deficiency of the results of the ratio greater than before,suggesting that abnormal exercise tolerance with the Qi-deficiency and blood stasis are the more important the relationship between the.
引文
[1]Murray CJ,et al.Mortality by cause of eight regions of the world:Global burden of disease Study.Lancet,1997;349:1269.
    [2]陈在嘉,高润霖.冠心病.北京:人民卫生出版社,2002;1100-1108.
    [3]黄春林 主编.心血管科专病中医临床诊治,北京:人民卫生出版社,2000:38-39.
    [4]李岚生,彭澍.冠心病危险因素研究进展[J].医师进修杂,2002,25(5):54-5
    [5]朱益民,陈坤.城市居民冠心病危险因素的病例对照研究.心肺血管病杂志,1995,14(2):64-68
    [6]刘宝英,黄慧玲等.冠心病危险因素的配对病例对照研究.福建医科大学学报,1998,32(3):296-299
    [7]李金平,邹耀红等.冠心病危险因素的病例对照分析.江南大学学报,2003,2(2):207-212
    [8]胡冬裴.胸痹证治文献研究.山东中医药大学学报,2005,29(1):37-40
    [9]李芳,樊相军胸痹诱发因素与辨证分型的调查分析 人民军医,2001,44(8):484-486.
    [10]文川,程伟 206例心纹痛患者问诊资料瘀中医辨证关系的探讨湖北中医杂志,2002,24(10):3-4.
    [11]吴辉,于扬文等116例冠心病患者中医证候及病因分析江苏中医药,2004,25(10):30-31.
    [12]于涛,曹洪欣胸痹(冠心病)证候演变规律的临床研究中医药信息,2004,21(3):44-46
    [13]Raymond J Gibbons MD FACC Chair et al.ACC/AHA Guide-lines for Exercise Testing:ExecutiveS ummary A Reort of the American Collcgeo fC ardiology /Americ an Heart Association Task Forceon Practice Guidelines(Commiteeo n Exereise Teating)Cireulation,1997;96:345-335
    [14]Kisacikll L,O zdemirK,Altinyay E,et al.Comparisiono fex ercisest resste stingwith simultaneous dobutamine stress echocardiography and technetium 99m iso nit rile single-photon emission computerized tomography ford lagnosis of cor on ary a rteryd isease,EurH eartJ,1996,17(1):113-119.
    [15]李保,刘卓敏,李运乾,等.冠状动脉造影与3种无创性检查诊断冠心病的对比分析.中华心血管病杂志1999;27(2):105-106.
    [16]李建国,秦永文,谢明1.46例平板运动试验假阳性假阴性原因分析.现代诊断与 治疗2000;11(5):264-266.
    [17]Fletcher GF,Flipse TR,kligfidld Petal.Currentstatusof ECG stress testiong.CurrPro b]Cardiol 1998;23(7):3604 23
    [18]王效增,韩雅玲,于海波.平板运动试验假阴性冠心病冠状动脉病变特点,第四军医大学学报 2003;24(3):254-256
    [19]ManchikalapadiP,[skandrianA(?).Whatis wrongw ithth etr eadmillex ercisete stJNu c]Cardio120 01;8(3):415-416
    [20]陈文革,徐映红,丁元芬,冠心病患者平板运动试验运动耐量测定的临床意义,心血管康复医学杂志2001;10(5)5406-5407
    [21]巩燕,何秉贤.运动平板负荷试验的现状与趋势.中国心血管杂志2001;6(1):50-53
    [22]邓玉莲,许春营,邱丽玫,等心电图负荷试验对无症状心肌缺血诊断的评价.心电学杂志1995;14(4):2172
    [23]李牧蔚,高传玉,黄克钧活动平板运动试验与冠状动脉病变临床相关性分析.医药论坛杂志2003;24(19):7-8
    [24]巩燕,何秉贤.运动平板负荷试验的运用及其进展,实用心电学杂志2001;10(1):52-53
    [25]杨柳,舒茂琴.活动平板试验结合冠心病危险因素对冠心病的诊断意义探讨.第三军医大学学报2004;26(2)167-168
    [26]包培蓉,吕同杰从火邪论治心纹痛.中国中医急症.1994,3(3):120-121
    [27]薛一涛,吴彤,刘伟.从血管内皮功能探讨情志因素与冠心病的关系.山东中医杂志,2005,24(6):323-324
    [28]鲁明源.湿热体质与冠心病,山东中医药大学学报,2003,27(1):16-20
    [29]胡冬裴.胸痹古今证型归类研究.上海中医药大学学报.2004,18(4):8-10
    [30]黄修涛,徐木林.冠心病“病证同一”与辨证思维模式.辽宁中医学院学报,2001,3(1):14-15
    [31]梁煜,林代华,王清.气虚血瘀是冠心病的病机关键释义.中医药学刊,2003,21(4):588-589.
    [32]陈俊文.略论冠心病的病机与治则,陕西中医,1996,17(9):407-408.
    [33]秦建国,胸痹心痛病机新论.辽宁中医杂志,2004,31(10);815-816.
    [34]吴焕林,阮新民,张敏州等.冠心病冠状动脉搭桥术后患者的中医证候分析,广州中医药大学学报,2000,17(3):228-230
    [35]林晓忠,吴焕林,严夏等.邓铁涛教授论诒冠心病规律探要.中医药学刊.2001,19(5):412-414
    [36]曹洪欣,张华敏,痰瘀互结与冠心病发病机理辨识.中医药学刊.2001,19(6): 544-545
    [37]李洁,解品启,王英震,冠心病心绞痛从痰瘀论治.陕西中医,2001,22(2):96-97
    [38]于涛,曹洪欣.胸痹(冠心病)病机演变探微.中医药信息,2004,21(2):1-347
    [39]吴整军,冠心病心绞痛病因的脏腑关系探讨.军医进修学院学报.2001,22(2).1-149。
    [40]周柄承,唐娟 冠心病从肝论治五法.湖北中医杂志,2001,23(10):19
    [41]刘绪银,冠心病从胆论治.甘肃中医,1997,10(4);3-4
    [42]张毅,范平,冠心病从肺论治探析.山东中医杂志,1998,17
    [43]朱喜英,刘龙民,陈建杰.论冠心病发病与胃之关系.云南中医学院学报,2001,(3):29-33
    [44]安辉,脾胃与冠病关系初探 湖南中医药1995 15(2):11-12
    [45]黄惠勇.冠心病病机的阶段论.中国医药学报.1996,11(2):21-23
    [46]李健,丁邦晗,张敏州等.胸痹心痛的临床证型与部分冠心病危险因素的中西医结合心脑血管病杂志.2005,3(2):97-99
    [47]丁邦晗,张敏州,张崟等.胸痹心痛并发高血压、糖尿病结合心脑血管病杂志.2004,2(3):125-127
    [48]陈伯钧,丁邦晗,张敏州,375例胸痹心痛患者临床2005,26(6):11-13
    [49]张桂明.冠心病心绞痛从虚实论治.长春中医学院学报.1994,10(45),8-9
    [50]黄永生,冠心病心绞痛临床诊治体会.长春中医学院学报.2005,21(1):16-17
    [51]申秀云.周信有教授冠心病辨治经验.甘肃中医学院学报,2000,17(1):5-6
    [52]张敏州,邹旭,李新梅等.胸痹心痛证冠状动脉造影100例临床分析,浙江中西医结杂志2002,16(1)14-15
    [53]Verani MS,Makmarian JJ,Iljxson JB,et al,Diagnosis of coronary artery disease by controlled coronary vasculation with adenosine and thallium-201 scintigraphy in patients unable to exercise.Circulation,1990,82:80.
    [54]Iskandrian AS.Myocardial ischem in during pharm aclogrcal stresstesing.Circulation,1993,97:1415.
    [55]Borges-Neto S,Mahmarian JJ,Jain A,et al.Quantitative thalli-um-201single photone mission computed tomography after ovaldi pyridamole for assessing the precence,anatomic location and severity of coronary artery disease.J Am Coll Cardiol,1988,11;962.
    [56]巩燕,何秉贤.运动平板负荷试验的运用及其进展.实用心电学杂志2001;10 (1):52-53
    [57]潘宜智,李广镰,曾冲等.临床研究冠心病患者运动试验中QRS波时限变化及其意义.中华心律失常学杂志1999;3(4):266-267
    [58]何艳萍,王红月,张密林等.运动试验QRS波时限变化对冠心病的诊断意义,中国厂矿医学2001;14(4)279
    [59]石蓓,秦瑶,陶敏.运动试骑QRS延长、QTd及ST下移对冠心病诊断价值的对比研究.遵义医学院学报2002;25(3):207-208
    [60]王效增,韩雅玲,于海波.平板运动试验假阴性冠心病冠状动脉病变特点第四军医大学学报2003;24(3):254-256
    [61]吴焕林,李新梅,罗文杰,等.邓氏冠心胶囊治疗冠心病稳定型心绞痛随机对照临床研究[J].中医杂志,2006,47(1):24-27.
    [62]吴焕林,王侠,李新梅,等.邓老冠心胶囊改善冠心病患者生活质量临床研究中国现代医学杂志,2005,15(16):2464-2468.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700