慢性丙型肝炎中医药辨证论治规律研究
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摘要
论文以中医学理论为基础,通过对慢性病毒性丙型肝炎的古代文献研究,现代中医药学对慢性病毒性丙型肝炎的研究、总结出慢性病毒性丙型肝炎的基本病因病机,近十五年中医药对慢性病毒性丙型肝炎辨证论治的文献研究,总结出慢性病毒性丙型肝炎的临床证型分布规律及治法分布规律,并对5年江苏省中医院门诊及病房和台湾地区收治的慢性病毒性丙型肝炎的辨证论治病例80例,了解江苏省和台湾地区慢性病毒性丙型肝炎的临床常见证型,并与文献研究结果相对比.全文共分为三个部分.
第一部分：回顾了历代中医文献对慢性病毒性丙型肝炎病名的认识.慢性病毒性丙型肝炎为现代医学病名,根据其病程的长短、受邪脏腑部位、病情演变过程及临床表现属中医学“黄疸”、“胁痛”、“症积”、“鼓胀”、“疫毒”、“肝瘟”等范畴.认为湿热疫毒是丙型病毒性肝炎发生的主要病因,饮食不洁、七情所伤、劳倦过度为加重因素,疫毒是慢性病毒性丙型肝炎的主要致病因素,湿热疫毒是发病之始因,肝血瘀滞是病变之核心,正气亏虚是疾病缠绵难愈的关键.病位在肝、脾、肾,病变过程中具有气滞、血瘀、致虚早等病机特点并创制了茵陈蒿汤、大黄庶虫丸、鳖甲煎丸、小柴胡汤、大柴胡汤、茵陈术附汤等临床行之有效的方剂.
第二部分：通过对近15年中医文献对慢性病毒性丙型肝炎辨证和治法的归纳.总结出慢性病毒性丙型肝炎的辨证论治规律及目前存在的问题,临床分型种类繁多,辨证分型方案缺少量化指标,辨治原则尚缺核心主干,制定量化微观辨证分型标准和治疗总则乃当务之急,我们通过对近15年对于慢性病毒性丙型肝炎中医辨证论治相关文献研究,临床常见证型按构成比的高低,排除兼夹证,化繁为简,血瘀证和肝郁脾虚证、湿热内蕴证为慢性病毒性丙型肝炎患者最为常见证型,而治法亦是以清热解毒,凉血化瘀为最常见.旨在为中医药治疗慢性病毒性丙型肝炎提供新的思路和方法.
第三部分：通过对80例临床慢性病毒性丙型肝炎病例的辨证分型,治法和常用药物的归纳,并与文献研究结果相比较,找出异同之处,探讨目前慢性病毒性丙型肝炎的辨证论治规律.考虑以五种基本证型为主,同时根据临床基本症状进行加减辨证论治,客观辨证与微观辨病研究相结合,对于无证可辨者,可以清热解毒,凉血化瘀这一最常见之法为基本大法论治.
The study of traditional chinese medicine differential diagnosis pattern in Chronic hepatitis C, modern traditional Chinese medicine on chronic viral hepatitis C research, summed up the basic chronic viral hepatitis C pathogenesis, nearly fifteen years Traditional Chinese Medicine Syndrome Differentiation and Treatment of the chronic viral hepatitis C, the literature summarized chronic viral hepatitis C, distribution of clinical syndromes, and treatment distribution, and collected the clincal case fromJiangsu Provincial Hospital out-patient and ward and taiwan treated for chronic toxicity Differential Treatment of hepatitis 80 cases from past 5 years and Understanding of Jiangsu province and Taiwan, chronic viral hepatitis C common clinical syndrome, and results were compared with the literature.Text is divided into three
PartⅠ:Review of the ancient Chinese medical literature on the chronic toxicity of awareness of hepatitis C disease name. Chronic viral hepatitis C disease name for modern medicine, according to the length of its course, by the evil parts of organs, evolution and clinical manifestations of disease are in the medical "jaundice " " hypochondriac pain, " " stasis "," bulging "," epidemic toxin, " "liver plague "and other areas.that the heat epidemic toxin is a major cause of hepatitis C occurred, eating unclean and injured seven emotions,weary over the contributing factors, epidemic toxin is the major chronic viral hepatitis C risk factors, the incidence of heat epidemic toxin is due to start, hepatic blood stasis is a disease of the heart, Righteousness deficiency is the key to the disease hard to be cured. Disease located in the liver, spleen, kidney, disease process with qi stagnation, blood stasis, caused by diseases such as virtual machine features of early and create their YinChenHaoTang, Da Huang Zhe Chong Wan,Biejiajian pill, Xiao Chai Hu Tang, Tai Chai Hu Tang, YinChenZhuFu decoction and other clinical effective prescription.parts.
PartⅡ:Through the past 15 years, literature on the chronic toxicity of TCM Syndrome Differentiation and Therapeutic Methods of hepatitis C induction. Concluded Differential Treatment of chronic viral hepatitis C, the law and the current problems in a wide range of clinical classification, classification type program lack of quantitative indicators, the principle of treating the core of the trunk is still missing, to develop quantitative standards for micro syndrome differentiation and treatment of general principles is a priority, we have adopted in recent 15 years for chronic viral hepatitis C related to traditional Chinese medicine, literature research, clinical syndromes according to component ratio the level of exclusion and folders permit to simplify, Blood stasis and stagnation and spleen deficiency, dampness evidence for chronic toxicity in patients with hepatitis C is the most common syndrome, but therapies are based on heat toxin, cooling blood as the most common. To a Chinese medicine treatment of chronic diseases toxic hepatitis C to provide new ideas and methods.
PartⅢ:The toxicity of 80 patients with chronic hepatitis C cases in syndrome differentiation, treatment method and the commonly used drugs, induction, and the results are compared with the literature, to identify similarities and differences and discussing the current chronic viral hepatitis C Differential Treatment rules.to consider the main five basic card types, while the basic symptoms of addition and subtraction based on clinical diagnosis and treatment, objective differentiation and disease differentiation of micro-combination can be identified for the undocumented who can heat toxin, cooling blood, the most common law as the basic law of governance.
第一部分：回顾了历代中医文献对慢性病毒性丙型肝炎病名的认识.慢性病毒性丙型肝炎为现代医学病名,根据其病程的长短、受邪脏腑部位、病情演变过程及临床表现属中医学“黄疸”、“胁痛”、“症积”、“鼓胀”、“疫毒”、“肝瘟”等范畴.认为湿热疫毒是丙型病毒性肝炎发生的主要病因,饮食不洁、七情所伤、劳倦过度为加重因素,疫毒是慢性病毒性丙型肝炎的主要致病因素,湿热疫毒是发病之始因,肝血瘀滞是病变之核心,正气亏虚是疾病缠绵难愈的关键.病位在肝、脾、肾,病变过程中具有气滞、血瘀、致虚早等病机特点并创制了茵陈蒿汤、大黄庶虫丸、鳖甲煎丸、小柴胡汤、大柴胡汤、茵陈术附汤等临床行之有效的方剂.
第二部分：通过对近15年中医文献对慢性病毒性丙型肝炎辨证和治法的归纳.总结出慢性病毒性丙型肝炎的辨证论治规律及目前存在的问题,临床分型种类繁多,辨证分型方案缺少量化指标,辨治原则尚缺核心主干,制定量化微观辨证分型标准和治疗总则乃当务之急,我们通过对近15年对于慢性病毒性丙型肝炎中医辨证论治相关文献研究,临床常见证型按构成比的高低,排除兼夹证,化繁为简,血瘀证和肝郁脾虚证、湿热内蕴证为慢性病毒性丙型肝炎患者最为常见证型,而治法亦是以清热解毒,凉血化瘀为最常见.旨在为中医药治疗慢性病毒性丙型肝炎提供新的思路和方法.
第三部分：通过对80例临床慢性病毒性丙型肝炎病例的辨证分型,治法和常用药物的归纳,并与文献研究结果相比较,找出异同之处,探讨目前慢性病毒性丙型肝炎的辨证论治规律.考虑以五种基本证型为主,同时根据临床基本症状进行加减辨证论治,客观辨证与微观辨病研究相结合,对于无证可辨者,可以清热解毒,凉血化瘀这一最常见之法为基本大法论治.
The study of traditional chinese medicine differential diagnosis pattern in Chronic hepatitis C, modern traditional Chinese medicine on chronic viral hepatitis C research, summed up the basic chronic viral hepatitis C pathogenesis, nearly fifteen years Traditional Chinese Medicine Syndrome Differentiation and Treatment of the chronic viral hepatitis C, the literature summarized chronic viral hepatitis C, distribution of clinical syndromes, and treatment distribution, and collected the clincal case fromJiangsu Provincial Hospital out-patient and ward and taiwan treated for chronic toxicity Differential Treatment of hepatitis 80 cases from past 5 years and Understanding of Jiangsu province and Taiwan, chronic viral hepatitis C common clinical syndrome, and results were compared with the literature.Text is divided into three
PartⅠ:Review of the ancient Chinese medical literature on the chronic toxicity of awareness of hepatitis C disease name. Chronic viral hepatitis C disease name for modern medicine, according to the length of its course, by the evil parts of organs, evolution and clinical manifestations of disease are in the medical "jaundice " " hypochondriac pain, " " stasis "," bulging "," epidemic toxin, " "liver plague "and other areas.that the heat epidemic toxin is a major cause of hepatitis C occurred, eating unclean and injured seven emotions,weary over the contributing factors, epidemic toxin is the major chronic viral hepatitis C risk factors, the incidence of heat epidemic toxin is due to start, hepatic blood stasis is a disease of the heart, Righteousness deficiency is the key to the disease hard to be cured. Disease located in the liver, spleen, kidney, disease process with qi stagnation, blood stasis, caused by diseases such as virtual machine features of early and create their YinChenHaoTang, Da Huang Zhe Chong Wan,Biejiajian pill, Xiao Chai Hu Tang, Tai Chai Hu Tang, YinChenZhuFu decoction and other clinical effective prescription.parts.
PartⅡ:Through the past 15 years, literature on the chronic toxicity of TCM Syndrome Differentiation and Therapeutic Methods of hepatitis C induction. Concluded Differential Treatment of chronic viral hepatitis C, the law and the current problems in a wide range of clinical classification, classification type program lack of quantitative indicators, the principle of treating the core of the trunk is still missing, to develop quantitative standards for micro syndrome differentiation and treatment of general principles is a priority, we have adopted in recent 15 years for chronic viral hepatitis C related to traditional Chinese medicine, literature research, clinical syndromes according to component ratio the level of exclusion and folders permit to simplify, Blood stasis and stagnation and spleen deficiency, dampness evidence for chronic toxicity in patients with hepatitis C is the most common syndrome, but therapies are based on heat toxin, cooling blood as the most common. To a Chinese medicine treatment of chronic diseases toxic hepatitis C to provide new ideas and methods.
PartⅢ:The toxicity of 80 patients with chronic hepatitis C cases in syndrome differentiation, treatment method and the commonly used drugs, induction, and the results are compared with the literature, to identify similarities and differences and discussing the current chronic viral hepatitis C Differential Treatment rules.to consider the main five basic card types, while the basic symptoms of addition and subtraction based on clinical diagnosis and treatment, objective differentiation and disease differentiation of micro-combination can be identified for the undocumented who can heat toxin, cooling blood, the most common law as the basic law of governance.
引文
[1]肖会泉,邓铁涛.治疗慢性丙型肝炎经脸.中医杂志,1999;40(9)：524
[2]陈瑞芳.益气健脾法治疗慢性丙型肝炎32例.新中医,2001;33(2)56
[3]中华医学会肝病学分会、中华医学会传染病与寄生虫病学分会.丙型肝炎防治指南.中华流行病学杂志,2004：25(5)：369-375
[4]李瑜,苏志达.干扰素抗肝纤维化的研究现状.医学信息,2001;14(8)：523-525
[5]韩硬海,李树桐主编.丙型肝炎.北京：人民卫生出版社,2004.6：172-205
[6]李干构.中西医对丙型肝炎的研究现状中国中西医结合消化杂志,2002,10(2)：120-123
[7]尤松鑫,周珉,薛博瑜,等.丙肝灵口服液治疗丙型肝炎的临床研究.中医杂志,1996,37(11)：673-675
[8]陈立华.丙型肝炎的特点及中医治法.中医杂志,1994,35(10)：621-622
[9]苏进才.丙型肝炎的中医论治.陕西中医学院学报,2003,26(1)：24-25
[10]张玮,王育群,季光,等.活血化瘀法为主治疗慢性丙型肝炎的临床研究.上海中医药杂志,2000,34(2)：25-26
[11]潘向荣.辨证治疗丙型肝炎18例.四川中医,2000,18(5)：26-278
[12]俞文军.肝乐合剂治疗慢性丙型肝炎32例临床观察.河北中医,2001,23(10)：736-73710]
[13]肖会泉.慢性丙型肝炎辨证分型临床探析.实用中医药杂志,2002,18(1)：38-39]
[14]洪余发.中医辨证论治慢性丙型肝炎46例临床观察.衡阳医学院学报,2000,28(1)
[15]邢练军,张玮,王育群,等.活血解毒为主治疗丙型病毒性肝炎20例.中医杂志,1994,35(5)：286-287
[16]肖倩.丙肝宁冲剂对慢性丙型肝炎患者IL-2、SIL-2R的影响.中西医结合肝病杂志,2002,12(4)：233
[17]刘敏,陈增潭.凉血解毒、柔肝理脾法治疗慢性丙型肝炎45例临床观察.中医杂志,1999,40(4)：227-228
[18]黄泰康.常用中药成分与药理手册[M].北京：中国医药科技出版社,1999：1576-1578
[19]周如珍,顾关云.黄芩的药理研究[J].中成药.1991;13(1)：28-29
[20]放贤,宋崇顺,周立孝.实用中药药理学[M]。北京：人民卫生出版社,1999
[21]李光,宋得新,蒋凯.升麻葛根汤加减加复方丹参注射液治疗慢性丙肝38例[J].河南中医药学刊,2001,16(2)：36-37
[22]张绍辉,秦佳波,韩忠孝.三草参汤治疗丙型肝炎56例体会.HEILONGJIANGMEDICINE AND PHARMACY,2002：25(4)：55
[23]殷杰,曾皓明,薛博瑜,等.丙肝宁冲剂治疗慢性丙型肝炎的临床研究[J].南京中医药大学学报(自然科学版),2002,18(1)：21-23
[24]孙明辉.丙肝煎治疗丙型病毒性肝炎48例[J].浙江中医杂志,1996,31(4)：149
[25]俞文军.肝乐合剂治疗慢性丙型肝炎32例临床观察.河北中医,2001,23(10)：736-73
[26]彭勃,任周新,黄朝阳,等.丙肝康对大鼠肝损伤的免疫功能的影响[J].山东中医药大学学报,2001,24(11)：461-463
[27]邱志济,邱江东.自拟速效丙肝丹治疗丙型肝炎举隅[J].辽宁中医杂志,1997,24(6)：277-278
[28]齐京,关幼波.益气活血解毒化痰治疗慢性丙肝的临床观察[J].中国中医基础医学杂志,2001,7(9)：46-48
[29]洪宁,郑健,许少峰,等.丙肝1号抗纤维化的临床研究[J].江西中医学院学报[J],2002,14(3)：36-37
[30]对中毒性肝损伤的防治作用《山西医药杂志》1975(3)：79～93
[31]缪辉来,林木生,张利强,等.加味大柴胡汤对阻塞性黄疸大鼠胆汁酸代谢的影响及机制[J].中华实验外科杂志,2006,23(8)：934-936
[32]吴干元.大黄蛰虫丸联合保肝治疗慢性丙型肝炎肝硬化疗效观察[J]光明中医2008
[33]伊藤隆·补中益气汤对慢性丙型肝炎的临床疗效：气虚证与疗效的关系(日)／／日本东洋医学杂志,1999 50(2).215-223
[34]杨丽春,张立友 参苓白术散加减治疗慢性丙型肝炎30例分析[J],中国误诊学杂志
[35]张希恩,王利华.大黄保肝利胆作用的药理与临床.中医药研究1995;(4)：56
[36]马安林,吴铁墉,董恩玉,等.藏红花对酒精及酒精加四氯化碳所致大鼠肝损伤的防治作用.中西医结合肝病杂志2000：10(6)：34
[37]龚环宇,万克青,唐世刚.冬虫夏草菌丝对慢性乙肝T细胞亚群和肝纤维化指标的影响.湖南医科大学学报2000：25(3)：248
[38]张杰,詹炳炎,姚学军,等.石榴皮对乙型肝炎病毒(HBV)的体外灭活作用及其临床意义.中药药理与临床1997：13(4)：29
[39]和水祥,舒昌杰.丹参对GSH-Px／MDA比值的影响及其在人肝细胞胶原合成中的作用.西北药学杂志1997：12(4)：158
[40]赵春景,王芳,赫飞·赤芍对乙肝黄疸患者红细胞通透性的影响中医药研究1999;15(5)：42
[41]马雄,邱德凯,徐军,等.冬虫夏草多糖治疗慢性丙型肝炎患者的临床研究.华人消化杂志1998;6(7)：582
[42]黎维勇,吴城德.胡黄连提取物降酶作用的研究.时珍国药研究1997;8(1)：18
[43]辛顺妹,沈美雯,马竹卿.口服苦参碱治疗动物肝损伤及临床应用初步观察.中药药理与临床1998;14(1)：42
[44]王晓玲,刘平,刘成海,等.丹酚酸A对成纤维细胞活力、增殖及胶原合成的影响.中西医结合肝病杂志,2000：10(1)：24
[45]邢练军,等.活血解毒为主治疗丙型病毒性肝炎20例.中医杂志 1994;35(5)：287
[46]金实,陈金良.丙型和乙型慢性肝炎的临床表现及中医辨证的比较研究.中医杂志,1994,35：538-539
[47]上海中医药人学附属曙光医院肝病科.全国第九届肝胆病学术会议论文集,2000.17.
[48]肖会泉.慢性丙型肝炎辨证分型临床探析.实用中医药杂志.2002.18(1)：38-39
[49]车念聪.付修文.高连印,北京地区慢性丙型肝炎中医证候学研究及辨证分型的初步调查.北京中医杂志.2002.21(5)：300-304
[50]王灵台,中医药治疗慢性丙型肝炎的现状和展望,中国中西医结合杂志[J],2008,28(1)：11-12
[51]病毒性肝炎防治方案.(试行)[j].中华内科杂志,1995,34(11)：788
[52]金实.病毒性肝炎中医论治诺干问题探讨.南京中医药大学学报,1996,12(4)：3-5
[53]汪承柏,等.重度黄疸型肝炎TXB2,PGFla变化和中医辩证关系的临床观察和实验研究.中西医结合杂志,1990,10,(3)：141-143
[54]王伯祥.中医肝胆病学.北京：中国医药科技出版社,1993
[55]郑民实,等.400种中草药对HbsAg的仰制作用.中国医药学报,1991,6(30)：30
[56]李时珍.本草纲目.北京：人民卫生出版社,1992,833-836
[57]王本祥.现代中药药理学.天津：天津科学技术出版社,1997,894
[58]彭文伟,杨绍基.传染病学,第5版.北京：人民卫生出版社,2002,73
[59]江苏新医学院.中药大词典.上海：上海科学技术出版社,2004,1003,1086
[60]杨世忠,刘庆彬,孙龙,等.丙型肝炎的中医药研究进展[J].长春中医学院学报,2003,18(2)：51-52
[61]中国中医药学会肝病专业委员会.病毒性肝炎中医辨证标准(试行)[S].中医杂志,1992,33(5)：397
[62]中华医学会.病毒性肝炎防治方案[S].中华传染病杂志,2001,19(1)：56-62
[63]郑筱萸.中药新药临床研究指导原则(试行)[M].北京：中国医药科技出版社,2002：143-150
[64]罗云坚,余绍源,黄穗平.消化科专病中医临床诊治[M].北京：人民卫生出版社,2005：89
[65]苏进才.丙型肝炎的中医论治[J].陕西中医学院学报,2003,26(1)：24-25
[66]王洪军,王泽坤,高桂森,等.慢性肝炎治法心得[J].吉林中医药,2005,25(12)：4-5
[67]武谦虎.常用治疗肝病中药[M].北京：中国医药科技出版社,2001：117-158
[68]中华医学会传染病与寄生虫病学分会,肝病学会.病毒性肝炎的诊断标准[J].中西医结合肝病杂志,2001,11：56-60
[69]中华人民共和国卫生部.中药新药临床研究指导原则.第一辑.1993：210 P 15-17
[70]焦一鸣,袁展群丙型肝炎证治概述[J]实用中医药杂志,2002,18(3)：52-53
[71]秦绍明,黄耀煊丙型肝炎[M]北京：人民军医出版社,1992.104
[72]郭仁,巩志立,蔡宏荣,等译病毒性肝炎现状与难点[M]北京：北京医科大学.中国协和医科大学联合出版社,1995.129
[73]陈瑞烈,贺永之,高勇,等丙型肝炎病毒对SMMC-7721细胞体外直接致病作用的研究[J]中西医结合肝病杂志,2002,12(1)：17-19
[74]洪慧闻,王江河,陈立华慢性乙型及丙型肝炎临床治疗特点分析[J]中医杂志,1997,38(12)：732-734
[75]夏秦,石淑仙,田德英,等地高辛标记原位杂交技术检测骨髓单个核细胞中HCV-RNA[J]中华传染病杂志
[76]车念聪.钱英中医药治疗丙型病毒性肝炎研究与展望1994(05)
[77]周珉.姜惟.薛博瑜慢性丙型肝炎的辨证规律探讨1998(07)
[78]金实.汪悦慢性丙型肝炎中医辨证分型与临床检测指标关系的探讨1998(04)
[2]陈瑞芳.益气健脾法治疗慢性丙型肝炎32例.新中医,2001;33(2)56
[3]中华医学会肝病学分会、中华医学会传染病与寄生虫病学分会.丙型肝炎防治指南.中华流行病学杂志,2004：25(5)：369-375
[4]李瑜,苏志达.干扰素抗肝纤维化的研究现状.医学信息,2001;14(8)：523-525
[5]韩硬海,李树桐主编.丙型肝炎.北京：人民卫生出版社,2004.6：172-205
[6]李干构.中西医对丙型肝炎的研究现状中国中西医结合消化杂志,2002,10(2)：120-123
[7]尤松鑫,周珉,薛博瑜,等.丙肝灵口服液治疗丙型肝炎的临床研究.中医杂志,1996,37(11)：673-675
[8]陈立华.丙型肝炎的特点及中医治法.中医杂志,1994,35(10)：621-622
[9]苏进才.丙型肝炎的中医论治.陕西中医学院学报,2003,26(1)：24-25
[10]张玮,王育群,季光,等.活血化瘀法为主治疗慢性丙型肝炎的临床研究.上海中医药杂志,2000,34(2)：25-26
[11]潘向荣.辨证治疗丙型肝炎18例.四川中医,2000,18(5)：26-278
[12]俞文军.肝乐合剂治疗慢性丙型肝炎32例临床观察.河北中医,2001,23(10)：736-73710]
[13]肖会泉.慢性丙型肝炎辨证分型临床探析.实用中医药杂志,2002,18(1)：38-39]
[14]洪余发.中医辨证论治慢性丙型肝炎46例临床观察.衡阳医学院学报,2000,28(1)
[15]邢练军,张玮,王育群,等.活血解毒为主治疗丙型病毒性肝炎20例.中医杂志,1994,35(5)：286-287
[16]肖倩.丙肝宁冲剂对慢性丙型肝炎患者IL-2、SIL-2R的影响.中西医结合肝病杂志,2002,12(4)：233
[17]刘敏,陈增潭.凉血解毒、柔肝理脾法治疗慢性丙型肝炎45例临床观察.中医杂志,1999,40(4)：227-228
[18]黄泰康.常用中药成分与药理手册[M].北京：中国医药科技出版社,1999：1576-1578
[19]周如珍,顾关云.黄芩的药理研究[J].中成药.1991;13(1)：28-29
[20]放贤,宋崇顺,周立孝.实用中药药理学[M]。北京：人民卫生出版社,1999
[21]李光,宋得新,蒋凯.升麻葛根汤加减加复方丹参注射液治疗慢性丙肝38例[J].河南中医药学刊,2001,16(2)：36-37
[22]张绍辉,秦佳波,韩忠孝.三草参汤治疗丙型肝炎56例体会.HEILONGJIANGMEDICINE AND PHARMACY,2002：25(4)：55
[23]殷杰,曾皓明,薛博瑜,等.丙肝宁冲剂治疗慢性丙型肝炎的临床研究[J].南京中医药大学学报(自然科学版),2002,18(1)：21-23
[24]孙明辉.丙肝煎治疗丙型病毒性肝炎48例[J].浙江中医杂志,1996,31(4)：149
[25]俞文军.肝乐合剂治疗慢性丙型肝炎32例临床观察.河北中医,2001,23(10)：736-73
[26]彭勃,任周新,黄朝阳,等.丙肝康对大鼠肝损伤的免疫功能的影响[J].山东中医药大学学报,2001,24(11)：461-463
[27]邱志济,邱江东.自拟速效丙肝丹治疗丙型肝炎举隅[J].辽宁中医杂志,1997,24(6)：277-278
[28]齐京,关幼波.益气活血解毒化痰治疗慢性丙肝的临床观察[J].中国中医基础医学杂志,2001,7(9)：46-48
[29]洪宁,郑健,许少峰,等.丙肝1号抗纤维化的临床研究[J].江西中医学院学报[J],2002,14(3)：36-37
[30]对中毒性肝损伤的防治作用《山西医药杂志》1975(3)：79～93
[31]缪辉来,林木生,张利强,等.加味大柴胡汤对阻塞性黄疸大鼠胆汁酸代谢的影响及机制[J].中华实验外科杂志,2006,23(8)：934-936
[32]吴干元.大黄蛰虫丸联合保肝治疗慢性丙型肝炎肝硬化疗效观察[J]光明中医2008
[33]伊藤隆·补中益气汤对慢性丙型肝炎的临床疗效：气虚证与疗效的关系(日)／／日本东洋医学杂志,1999 50(2).215-223
[34]杨丽春,张立友 参苓白术散加减治疗慢性丙型肝炎30例分析[J],中国误诊学杂志
[35]张希恩,王利华.大黄保肝利胆作用的药理与临床.中医药研究1995;(4)：56
[36]马安林,吴铁墉,董恩玉,等.藏红花对酒精及酒精加四氯化碳所致大鼠肝损伤的防治作用.中西医结合肝病杂志2000：10(6)：34
[37]龚环宇,万克青,唐世刚.冬虫夏草菌丝对慢性乙肝T细胞亚群和肝纤维化指标的影响.湖南医科大学学报2000：25(3)：248
[38]张杰,詹炳炎,姚学军,等.石榴皮对乙型肝炎病毒(HBV)的体外灭活作用及其临床意义.中药药理与临床1997：13(4)：29
[39]和水祥,舒昌杰.丹参对GSH-Px／MDA比值的影响及其在人肝细胞胶原合成中的作用.西北药学杂志1997：12(4)：158
[40]赵春景,王芳,赫飞·赤芍对乙肝黄疸患者红细胞通透性的影响中医药研究1999;15(5)：42
[41]马雄,邱德凯,徐军,等.冬虫夏草多糖治疗慢性丙型肝炎患者的临床研究.华人消化杂志1998;6(7)：582
[42]黎维勇,吴城德.胡黄连提取物降酶作用的研究.时珍国药研究1997;8(1)：18
[43]辛顺妹,沈美雯,马竹卿.口服苦参碱治疗动物肝损伤及临床应用初步观察.中药药理与临床1998;14(1)：42
[44]王晓玲,刘平,刘成海,等.丹酚酸A对成纤维细胞活力、增殖及胶原合成的影响.中西医结合肝病杂志,2000：10(1)：24
[45]邢练军,等.活血解毒为主治疗丙型病毒性肝炎20例.中医杂志 1994;35(5)：287
[46]金实,陈金良.丙型和乙型慢性肝炎的临床表现及中医辨证的比较研究.中医杂志,1994,35：538-539
[47]上海中医药人学附属曙光医院肝病科.全国第九届肝胆病学术会议论文集,2000.17.
[48]肖会泉.慢性丙型肝炎辨证分型临床探析.实用中医药杂志.2002.18(1)：38-39
[49]车念聪.付修文.高连印,北京地区慢性丙型肝炎中医证候学研究及辨证分型的初步调查.北京中医杂志.2002.21(5)：300-304
[50]王灵台,中医药治疗慢性丙型肝炎的现状和展望,中国中西医结合杂志[J],2008,28(1)：11-12
[51]病毒性肝炎防治方案.(试行)[j].中华内科杂志,1995,34(11)：788
[52]金实.病毒性肝炎中医论治诺干问题探讨.南京中医药大学学报,1996,12(4)：3-5
[53]汪承柏,等.重度黄疸型肝炎TXB2,PGFla变化和中医辩证关系的临床观察和实验研究.中西医结合杂志,1990,10,(3)：141-143
[54]王伯祥.中医肝胆病学.北京：中国医药科技出版社,1993
[55]郑民实,等.400种中草药对HbsAg的仰制作用.中国医药学报,1991,6(30)：30
[56]李时珍.本草纲目.北京：人民卫生出版社,1992,833-836
[57]王本祥.现代中药药理学.天津：天津科学技术出版社,1997,894
[58]彭文伟,杨绍基.传染病学,第5版.北京：人民卫生出版社,2002,73
[59]江苏新医学院.中药大词典.上海：上海科学技术出版社,2004,1003,1086
[60]杨世忠,刘庆彬,孙龙,等.丙型肝炎的中医药研究进展[J].长春中医学院学报,2003,18(2)：51-52
[61]中国中医药学会肝病专业委员会.病毒性肝炎中医辨证标准(试行)[S].中医杂志,1992,33(5)：397
[62]中华医学会.病毒性肝炎防治方案[S].中华传染病杂志,2001,19(1)：56-62
[63]郑筱萸.中药新药临床研究指导原则(试行)[M].北京：中国医药科技出版社,2002：143-150
[64]罗云坚,余绍源,黄穗平.消化科专病中医临床诊治[M].北京：人民卫生出版社,2005：89
[65]苏进才.丙型肝炎的中医论治[J].陕西中医学院学报,2003,26(1)：24-25
[66]王洪军,王泽坤,高桂森,等.慢性肝炎治法心得[J].吉林中医药,2005,25(12)：4-5
[67]武谦虎.常用治疗肝病中药[M].北京：中国医药科技出版社,2001：117-158
[68]中华医学会传染病与寄生虫病学分会,肝病学会.病毒性肝炎的诊断标准[J].中西医结合肝病杂志,2001,11：56-60
[69]中华人民共和国卫生部.中药新药临床研究指导原则.第一辑.1993：210 P 15-17
[70]焦一鸣,袁展群丙型肝炎证治概述[J]实用中医药杂志,2002,18(3)：52-53
[71]秦绍明,黄耀煊丙型肝炎[M]北京：人民军医出版社,1992.104
[72]郭仁,巩志立,蔡宏荣,等译病毒性肝炎现状与难点[M]北京：北京医科大学.中国协和医科大学联合出版社,1995.129
[73]陈瑞烈,贺永之,高勇,等丙型肝炎病毒对SMMC-7721细胞体外直接致病作用的研究[J]中西医结合肝病杂志,2002,12(1)：17-19
[74]洪慧闻,王江河,陈立华慢性乙型及丙型肝炎临床治疗特点分析[J]中医杂志,1997,38(12)：732-734
[75]夏秦,石淑仙,田德英,等地高辛标记原位杂交技术检测骨髓单个核细胞中HCV-RNA[J]中华传染病杂志
[76]车念聪.钱英中医药治疗丙型病毒性肝炎研究与展望1994(05)
[77]周珉.姜惟.薛博瑜慢性丙型肝炎的辨证规律探讨1998(07)
[78]金实.汪悦慢性丙型肝炎中医辨证分型与临床检测指标关系的探讨1998(04)