三种牙本质脱敏剂对粘接剂粘接强度的影响
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摘要
临床上行全冠修复时,为了预备出修复体的空间以及取得共同就位道,必须切割牙体组织,导致牙本质暴露,而且修复过程中暂时冠或修复体的质量不佳,边缘不密合等,均可造成术后敏感。根据流体动力学说,机械封闭暴露的牙本质小管,可以防止牙本质敏感及保护牙髓。因此,众多的脱敏产品应运而生,大量的临床实践证明该方法行之有效。然而,涂布牙本质脱敏剂是否会影响粘接剂的粘接强度,目前的报道较少。
[目的]
本课题旨在观察涂布脱敏剂后牙本质小管的微观形貌特征,研究脱敏剂对粘接剂粘接剪切强度的影响,为临床上选用脱敏剂和粘接剂提供实验依据。
[方法]
用金刚砂车针均匀磨除离体牙牙合面釉质,暴露牙本质。按不同分组分别涂布Hybrid Coat、Prime&Bond NT、脱敏牙膏,再用扫描电镜观察牙本质小管的微观形貌特征。分别用玻璃离子水门汀(GIC)、聚羧锌酸水门汀(PCC)、树脂粘接剂(RC),将钻铬合金粘接接头粘接到经脱敏剂处理的牙本质表面,在万能试验机上测试样本的粘接剪切强度。
[结果]
1.扫描电镜观察：Hybrid Coat、Prime&Bond NT几乎能封闭所有的牙本质小管口,而脱敏牙膏涂布后有少量牙本质小管口开放,小管中均可见沉积物。
2.剪切实验：Hybrid Coat能增加GIC的粘接剪切强度,而对PCC、RC的粘接剪切强度没有显著影响；Prime&Bond NT显著降低了PCC的粘接剪切强度,而对GIC、RC没有显著影响；高露洁专效抗敏牙膏可以增加PCC、RC的粘接剪切强度,而对GIC没有显著影响；本实验选用的三种粘接剂中,GIC的粘接剪切强度最低,RC的粘接剪切强度最高。
[结论]
1. Hybrid Coat、Prime&Bond NT、脱敏牙膏均可以封闭牙本质小管。
2.临床上用GIC粘接钴铬合金修复体,宜选用Hybrid Coat脱敏处理；用PCC粘接钻铬合金修复体,应避免与Prime&Bond NT配伍；用RC、PCC粘接钻铬合金修复体,宜选用高露洁专效抗敏牙膏脱敏处理。
Full crown restoration needs tooth preparation in order to obtain the space and the common insertion path for prosthesis. It has been shown that a lot of dentinal tubules were exposed after tooth preparation, which increased the potential of postoperative dentine sensitivity. What's more, many other factors can also induce hypersensitivity such as temporary crowns or final restorations of poor quality and marginal microleakage. According to the hydrodynamic theory which has been widely accepted, we can prevent hypersensitivity and protect pulp tissue by mechanical closure of exposed dentinal tubules. As a result, many desensitizers come into being. And a great number of clinical trials have proved that they can effectively reduce the extent of sensitivity. However, reports about the effect of desensitizers on bond strength of luting agents are few.
Objective:The purpose of this study was to observe the microscopic characteristics of dentinal tubules after using desensitizers, to test their effect on the bond strength of cementing agents and to provide an experimental basis for the selection of desensitizers and adhesives in clinic.
Methods:Freshly extracted human premolars were prepared with a speed handpiece and the dentinal tubules were exposed. After using Hybrid Coat, Prime&Bond NT, anti-sensitivity toothpaste in corresponding groups, the microscopic characteristics of dentinal tubules were observed with scanning electron microscopy. After all the dentine surfaces had been treated by the selected desensitizers, castings of cobalt-chromium alloy were bonded to them by glass ionomer cement(GIC), zinc polycarboxylate cement(PCC), resin adhesive(RC) respectively. The shear bond strength of each specimen was obtained using a universal testing machine.
Results:1. Hybrid Coat, Prime&Bond NT could occlude almost all the exposed tubules while anti-sensitivity toothpaste could only seal the majority of tubules. Sediments were visible no matter which desensitizer was used.
2. Hybrid Coat could significantly increase the shear bond strength of GIC, but had no effect on the bond strength of PCC and RC. Application of Prime&Bond NT reduced the shear bond strength when PCC was used, but did not affect the shear bond strength of GIC, RC. The use of anti-sensitivity toothpaste obviously enhanced the shear bond strength of RC and PCC, but had no negative impacts on the shear bond strength of GIC, RC. Among the selected luting agents, GIC had the lowest shear bond strength while RC had the highest.
Conclusion:1. Hybrid Coat, Prime&Bond NT and anti-sensitivity toothpaste are able to seal dentinal tubules.2. When use GIC as adhesive agent, we shoud choose Hybrid Coat as dentine desensitizer; if we choose PCC, the use of Prime&Bond NT should be avoided; if RC or PCC is selected, anti-sensitivity toothpaste is applicable.
[目的]
本课题旨在观察涂布脱敏剂后牙本质小管的微观形貌特征,研究脱敏剂对粘接剂粘接剪切强度的影响,为临床上选用脱敏剂和粘接剂提供实验依据。
[方法]
用金刚砂车针均匀磨除离体牙牙合面釉质,暴露牙本质。按不同分组分别涂布Hybrid Coat、Prime&Bond NT、脱敏牙膏,再用扫描电镜观察牙本质小管的微观形貌特征。分别用玻璃离子水门汀(GIC)、聚羧锌酸水门汀(PCC)、树脂粘接剂(RC),将钻铬合金粘接接头粘接到经脱敏剂处理的牙本质表面,在万能试验机上测试样本的粘接剪切强度。
[结果]
1.扫描电镜观察：Hybrid Coat、Prime&Bond NT几乎能封闭所有的牙本质小管口,而脱敏牙膏涂布后有少量牙本质小管口开放,小管中均可见沉积物。
2.剪切实验：Hybrid Coat能增加GIC的粘接剪切强度,而对PCC、RC的粘接剪切强度没有显著影响；Prime&Bond NT显著降低了PCC的粘接剪切强度,而对GIC、RC没有显著影响；高露洁专效抗敏牙膏可以增加PCC、RC的粘接剪切强度,而对GIC没有显著影响；本实验选用的三种粘接剂中,GIC的粘接剪切强度最低,RC的粘接剪切强度最高。
[结论]
1. Hybrid Coat、Prime&Bond NT、脱敏牙膏均可以封闭牙本质小管。
2.临床上用GIC粘接钴铬合金修复体,宜选用Hybrid Coat脱敏处理；用PCC粘接钻铬合金修复体,应避免与Prime&Bond NT配伍；用RC、PCC粘接钻铬合金修复体,宜选用高露洁专效抗敏牙膏脱敏处理。
Full crown restoration needs tooth preparation in order to obtain the space and the common insertion path for prosthesis. It has been shown that a lot of dentinal tubules were exposed after tooth preparation, which increased the potential of postoperative dentine sensitivity. What's more, many other factors can also induce hypersensitivity such as temporary crowns or final restorations of poor quality and marginal microleakage. According to the hydrodynamic theory which has been widely accepted, we can prevent hypersensitivity and protect pulp tissue by mechanical closure of exposed dentinal tubules. As a result, many desensitizers come into being. And a great number of clinical trials have proved that they can effectively reduce the extent of sensitivity. However, reports about the effect of desensitizers on bond strength of luting agents are few.
Objective:The purpose of this study was to observe the microscopic characteristics of dentinal tubules after using desensitizers, to test their effect on the bond strength of cementing agents and to provide an experimental basis for the selection of desensitizers and adhesives in clinic.
Methods:Freshly extracted human premolars were prepared with a speed handpiece and the dentinal tubules were exposed. After using Hybrid Coat, Prime&Bond NT, anti-sensitivity toothpaste in corresponding groups, the microscopic characteristics of dentinal tubules were observed with scanning electron microscopy. After all the dentine surfaces had been treated by the selected desensitizers, castings of cobalt-chromium alloy were bonded to them by glass ionomer cement(GIC), zinc polycarboxylate cement(PCC), resin adhesive(RC) respectively. The shear bond strength of each specimen was obtained using a universal testing machine.
Results:1. Hybrid Coat, Prime&Bond NT could occlude almost all the exposed tubules while anti-sensitivity toothpaste could only seal the majority of tubules. Sediments were visible no matter which desensitizer was used.
2. Hybrid Coat could significantly increase the shear bond strength of GIC, but had no effect on the bond strength of PCC and RC. Application of Prime&Bond NT reduced the shear bond strength when PCC was used, but did not affect the shear bond strength of GIC, RC. The use of anti-sensitivity toothpaste obviously enhanced the shear bond strength of RC and PCC, but had no negative impacts on the shear bond strength of GIC, RC. Among the selected luting agents, GIC had the lowest shear bond strength while RC had the highest.
Conclusion:1. Hybrid Coat, Prime&Bond NT and anti-sensitivity toothpaste are able to seal dentinal tubules.2. When use GIC as adhesive agent, we shoud choose Hybrid Coat as dentine desensitizer; if we choose PCC, the use of Prime&Bond NT should be avoided; if RC or PCC is selected, anti-sensitivity toothpaste is applicable.
引文
[1]朱智敏.冠桥修复后的临床常见问题及处理对策.中国实用口腔科杂志.2009,2(8)：449-451.
[2]赵铱民.口腔修复学(第六版).北京：人民卫生出版社,2003：73-74.
[3]Bergenholtz G, Cox CF, Loesche WJ, et al. Bacterial leakage around dental restorations:its effect on the dental pulp. J Oral Pathol.1982,11(6):439-450.
[4]江南,朱梅,史久成.金属烤瓷修复的牙髓评价.牙体牙髓牙周病学杂志.2000,10(06)：347-348.
[5]Sengun A, Koyuturk AE, Sener Y, et al. Effect of desensitizers on the bond strength of a self-etching adhesive system to caries-affected dentin on the gingival wall. Oper Dent.2005,30(4):430-435.
[6]Yim NH, Rueggeberg FA, Caughman WF, et al. Effect of dentin desensitizers and cementing agents on retention of full crowns using standardized crown preparations. J Prosthet Dent.2000,83(4):459-465.
[7]Soeno K, Taira Y, Matsumura H, et al. Effect of desensitizers on bond strength of adhesive luting agents to dentin. J Oral Rehabil.2001,28(12):1122-1128.
[8]Nikaido T, Nakaoki Y, Ogata M, et al. The resin-coating technique. Effect of a single-step bonding system on dentin bond strengths. J Adhes Dent.2003,5(4): 293-300.
[9]陈锡平,王庆,毕玮.劲润(Hybrid Coat)治疗活髓牙全冠制备后牙本质过敏的临床研究.中国临床医学.2010,17(3)：432-433.
[10]Ayad F, Ayad N. Comparing the efficacy in providing instant relief of dentine hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchamark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride:A Three-day clinical study in Mississauga, Canada.2009:20,115-122.
[11]李启艳,汤颖聪,杨睿Fluor Protector和Prime&Bond NT粘接剂对牙本质过敏症的治疗.中国误诊学杂志.2005,5(5)：860-861.
[12]王雪,李金华,牟建钢.脱敏剂封闭牙本质小管的微结构特征及其对树脂粘接剂粘接强度的影响.华西口腔医学杂志.2008,26(3)：233-236.
[13]Shafiei F, Memarpour M. Effect of repeated use on dentin bond strength of two adhesive systems:all-in-one and one-bottle. Indian J Dent Res.2009,20(2): 180-184.
[14]Docimo R, Montesani L, Maturo P, et al. Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion:an eight-week clinical study in Rome, Italy. J Clin Dent.2009,20(1):17-22.
[15]Kleinberg I. SensiStat. A new saliva-based composition for simple and effective treatment of dentinal sensitivity pain. Dent Today.2002,21(12):42-47.
[16]Petrou I, Heu R, Stranick M, et al. A breakthrough therapy for dentin hypersensitivity:how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth. J Clin Dent.2009, 20(1):23-31.
[17]解保生,Dickens SH, Schumacher G两种牙本质粘接剂粘接界面的扫描电镜研究.四川大学学报(医学版).2003,34(2)：270-273.
[18]Suge T, Ishikawa K, Kawasaki A, et al. Effects of fluoride on the calcium phosphate precipitation method for dentinal tubule occlusion. J Dent Res.1995, 74(4):1079-1085.
[19]Pashley DH, Carvalho RM, Pereira JC, et al. The use of oxalate to reduce dentin permeability under adhesive restorations. Am J Dent.2001,14(2):89-94.
[20]Hara AT, Pimenta LA, Jr Rodrigues AL. Influence of cross-head speed on resin-dentin shear bond strength. Dent Mater.2001,17(2):165-169.
[21]Johnson GH, Lepe X, Bales DJ. Crown retention with use of a 5% glutaraldehyde sealer on prepared dentin. J Prosthet Dent.1998,79(6):671-676.
[22]Cheng JT, Itoh K, Kusunoki M, et al. Effect of dentine conditioners on the bonding efficacy of one-bottle adhesives. J Oral Rehabil.2005,32(1):28-33.
[23]Wolfart S, Linnemann J, Kern M. Crown retention with use of different sealing systems on prepared dentine. J Oral Rehabil.2003,30(11):1053-1061.
[24]Kent WA, Jr Shillingburg HT, Jr Duncanson MG. Taper of clinical preparations for cast restorations. Quintessence Int.1988,19(5):339-345.
[25]Swift EJ, Lloyd AH, Felton DA. The effect of resin desensitizing agents on crown retention. J Am Dent Assoc.1997,128(2):195-200.
[26]陈治清.口腔材料学(第3版).北京：人民卫生出版社,2002：134.
[27]Ermis RB, Gokay N. Effect of fluorosis on dentine shear bond strength of a self-etching bonding system. J Oral Rehabil.2003,30(11):1090-1094.
[28]刘文侠,郭庆泰,丁伟山.钴铬合金和陶瓷间粘结强度研究.口腔材料器械杂志.2005,14(1)：5-8.
[29]Capa N, Ozkurt Z, Canpolat C, et al. Shear bond strength of luting agents to fixed prosthodontic restorative core materials. Aust Dent J.2009,54(4): 334-340.
[30]张鸣雷,王景云,吴健.钻铬合金烤瓷冠与镍铬合金烤瓷冠的临床使用效果比较与分析.吉林医学.2007,28(9)：1093-1094.
[31]孙平,盛祖立,张正仪.4种临床用烤瓷合金材料细胞毒性研究.口腔医学.2004,24(6)：344-346.
[32]巢永烈,刘长虹,李宁.牙用烤瓷支架钴铬钼合金的研制及机械性能的测试.华西口腔医学杂志.2005,23(1)：17-20.
[33]杨晓喻,刘长虹,巢永烈.牙用烤瓷支架钴铬钼合金热膨胀系数的测定.广东牙病防治.2006,14(2)：114-115.
[34]赵三军.牙本质粘接效果的评价方法及影响因素.国外医学.口腔医学分册.2002,29(5)：292-294.
[35]Scherrer S, Cesar PF, Swain MV. Direct comparison of the bond strength results of the different test methods:a critical literature review. Dent Mater.2010, 26(2):78-93.
[36]Camps J, Martin P, Ladeque P, et al. Influence of tooth cryopreservation on human dentin permeability, in vitro. Dent Mater.1994,10(3):210-214.
[37]Habelitz S, Jr Marshall GW, Balooch M, et al. Nanoindentation and storage of teeth. J Biomech.2002,35(7):995-998.
[38]Dahl B, Oilo G. Retentive properties of luting cements:an in vitro investigation. Dent Mater.1986,2(1):17-20.
[39]Diaz-Arnold AM, Vargas MA, Haselton DR. Current status of luting agents for fixed prosthodontics. J Prosthet Dent.1999,81(2):135-141.
[40]陈新民,王劲茗,孙俊.不同粘接剂的粘接力与机械嵌合力在金属全冠固位中的作用.华西医科大学学报.2001,32(2)：260-263.
[41]凌晨MS Coat脱敏剂对牙体预备后基牙牙本质敏感症疗效的研究：[硕士学位论文].成都：四川大学,2006.
[42]Mausner IK, Goldstein GR, Georgescu M. Effect of two dentinal desensitizing agents on retention of complete cast coping using four cements. J Prosthet Dent. 1996,75(2):129-134.
[43]Garcia-Godoy A, Garcia-Godoy F. Effect of an 8.0% arginine and calcium carbonate in-office desensitizing paste on the shear bond strength of composites to human dental enamel. Am J Dent.2010,23(6):324-326.
[44]游杰,周望梅.不同粘结剂对玻璃纤维桩与根管内牙本质粘结强度比较.广东医学.2009,30(09)：1317-1319.
[45]Burke FM, Lynch E. Glass polyalkenoate bond strength to dentine after chemomechanical caries removal. J Dent.1994,22(5):283-291.
[46]李苗健,张朋,秦红霞Gluma脱敏剂对黏接剂与牙本质间粘接力的作用.河南医学研究.2008,17(2)：146-148.
[1]江南,朱梅,史久成.金属烤瓷修复的牙髓评价.牙体牙髓牙周病学杂志.2000.6：347-348.
[2]赵铱民.口腔修复学(第六版).北京：人民卫生出版社,2003：73-74.
[3]Richardson D, Tao L, Pashley DH. Dentin permeability:effects of crown preparation. Int J Prosthodont.1991,4(3):219-225.
[4]张倩,程祥荣,何俐.全冠牙体预备后影响牙髓-牙本质复合体反应因素的研究.武汉大学学报(医学版).2005,3：355-358.
[5]Camps J, Dejou J, Remusat M, et al. Factors influencing pulpal response to cavity restorations. Dent Mater.2000,16(6):432-440.
[6]Zach L, Cohen G. Pulp response to externally applied heat. Oral Surg Oral Med Oral Pathol.1965,19:515-530.
[7]郑弟泽,牟雁东.冠修复牙体预备对髓腔温度影响的实验研究.华西口腔医学杂志.1998,16(3)：270-273.
[8]Christensen GJ. Tooth preparation and pulp degeneration. J Am Dent Assoc. 1997,128(3):353-354.
[9]Young HM, Smith CT, Morton D. Comparative in vitro evaluation of two provisional restorative materials. J Prosthet Dent.2001,85(2):129-132.
[10]Ogawa T, Aizawa S, Tanaka M, et al. Effect of water temperature on the fit of provisional crown margins during polymerization. J Prosthet Dent.1999,82(6): 658-661.
[11]Castelnuovo J, Tjan AH. Temperature rise in pulpal chamber during fabrication of provisional resinous crowns. J Prosthet Dent.1997,78(5):441-446.
[12]Murray PE, Hafez AA, Smith AJ, et al. Identification of hierarchical factors to guide clinical decision making for successful long-term pulp capping. Quintessence Int.2003,34(1):61-70.
[13]Rosenstiel SF, Land MF, Crispin BJ. Dental luting agents:A review of the current literature. J Prosthet Dent.1998,80(3):280-301.
[14]陈治清.口腔材料学(第3版).北京：人民卫生出版社,2002：134.
[15]White SN. Adhesive cements and cementation. J Calif Dent Assoc.1993,21(6): 30-37.
[16]Hegarty D, Macfarlane T. In vivo bracket retention comparison of a resin-modified glass ionomer cement and a resin-based bracket adhesive system after a year. Am J Orthod Dentofacial Orthop.2002,121(5):496-501.
[17]郑庄,唐亮.粘接材料与口腔固定修复的微渗漏(讲座).暨南大学学报(自然科学与医学版).2003(04)：111-114.
[18]许凌云,曾利伟.4种黏接剂对全瓷颈缘和合金颈缘的金属烤瓷冠微渗漏影响的对比研究.广东牙病防治.2008,16(06)：266-268.
[19]朱镇,王景云.修复体边缘微漏的影响因素及控制办法.口腔颌面修复学杂志.2002,3(02)：127-129.
[20]Lindquist TJ, Connolly J. In vitro microleakage of luting cements and crown foundation material. J Prosthet Dent.2001,85(3):292-298.
[21]Piwowarczyk A, Lauer HC, Sorensen JA. Microleakage of various cementing agents for full cast crowns. Dent Mater.2005,21(5):445-453.
[22]Orchardson R, Gillam DG. Managing dentin hypersensitivity. J Am Dent Assoc. 2006,137(7):990-998.
[23]Irvine JH. Root surface sensitivity:a review of aetiology and management. Soc Periodontol.1988,66:15-18.
[24]Orchardson R, Cadden SW. An update on the physiology of the dentine-pulp complex. Dent Update.2001,28(4):200-209.
[25]Chidchuangchai W, Vongsavan N, Matthews B. Sensory transduction mechanisms responsible for pain caused by cold stimulation of dentine in man. Arch Oral Biol.2007,52(2):154-160.
[26]于世凤.口腔组织病理学.北京：人民卫生出版社,2007：63.
[27]Pashley DH. Dynamics of the pulpo-dentin complex. Crit Rev Oral Biol Med. 1996,7(2):104-133.
[28]Brannstrom M, Astrom A. The hydrodynamics of the dentine; its possible relationship to dentinal pain. Int Dent J.1972,22(2):219-227.
[29]Rimondini L, Baroni C, Carrassi A. Ultrastructure of hypersensitive and non-sensitive dentine. A study on replica models. J Clin Periodontol.1995, 22(12):899-902.
[30]Dondi DG, Lone A, Finger WJ. Clinical evaluation of the role of glutardialdehyde in a one-bottle adhesive. Am J Dent.2002,15(5):330-334.
[31]Schupbach P, Lutz F, Finger WJ. Closing of dentinal tubules by Gluma desensitizer. Eur J Oral Sci.1997,105:414-421.
[32]Markowitz K, Bilotto G, Kim S. Decreasing intradental nerve activity in the cat with potassium and divalent cations. Arch Oral Biol.1991,36(1):1-7.
[33]Peacock JM, Orchardson R. Effects of potassium ions on action potential conduction in A- and C-fibers of rat spinal nerves. J Dent Res.1995,74(2): 634-641.
[34]Frechoso SC, Menendez M, Guisasola C, et al. Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial. J Clin Periodontol.2003,30(4): 315-320.
[35]任常群.牙本质过敏症的治疗进展.口腔医学纵横.2000,16(03)：232-233.
[36]Topbasi B, Turkmen C, Gunday M. An investigation of the effect of a desensitizing dentifrice on dentinal tubules in vitro and in vivo. Quintessence Int.1998,29(3):197-199.
[37]Kleinberg I. SensiStat. A new saliva-based composition for simple and effective treatment of dentinal sensitivity pain. Dent Today.2002,21(12):42-47.
[38]Petrou I, Heu R, Stranick M, et al. A breakthrough therapy for dentin hypersensitivity:how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth. J Clin Dent.2009, 20(1):23-31.
[39]Vieira AH, Santiago S L. Management of dentinal hypersensitivity. Gen Dent. 2009,57(2):120-126,127-128.
[40]Kern DA, Mcquade MJ, Scheidt MJ, et al. Effectiveness of sodium fluoride on tooth hypersensitivity with and without iontophoresis. J Periodontol.1989, 60(7):386-389.
[41]陈丽娟,祁惠兰,任长海.氟离子导入对牙本质小管封闭作用的实验研究.口腔医学.2007,27(02)：99-101.
[42]Leonard RH, Smith LR, Garland GE, et al. Desensitizing agent efficacy during whitening in an at-risk population. J Esthet Restor Dent.2004,16(1):49-56.
[43]Suge T, Kawasaki A, Ishikawa K, et al. Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion. Dent Mater.2008,24(2):192-198.
[44]Suge T, Kawasaki A, Ishikawa K, et al. Effect of ammonium hexafluorosilicate on dentin tubule occlusion for the treatment of dentin hypersensitivity. Am J Dent.2006,19(4):248-252.
[45]Arrais CA, Chan DC, Giannini M. Effects of desensitizing agents on dentinal tubule occlusion. J Appl Oral Sci.2004,12(2):144-148.
[46]Pillon F. Effect of a 3% potassium oxalate topical application on dentinal hypersensitivity after subgingival scaling and root planing.2004,75(11): 1464-1465.
[47]陆梅,高宁,岑远坤Gluma脱敏剂治疗活髓牙全冠牙体预备后敏感症的临床疗效和扫描电镜观察.口腔颌面修复学杂志.2006,7(04)：266-268.
[48]Cesar Augusto Galvao Arrais D C N C. Effect of desensitizing agents on dentinal tubule occlusion.2004,12(2):144-148.
[49]邢晓艳,刘士有,张青松Seal&Protect-(TM)对牙本质作用的扫描电镜研究.现代口腔医学杂志.2002,16(01)：28-29.
[50]王盼盼,陈新梅.3种家用脱敏剂阻塞牙本质小管的实验研究.国际口腔医学杂志.2010,37(05)：511-515.
[51]Nikaido T, Nakaoki Y, Ogata M, et al. The resin-coating technique. Effect of a single-step bonding system on dentin bond strengths. J Adhes Dent.2003,5(4): 293-300.
[52]潘鸣镝,黄轶锋.3种脱敏剂封闭牙本质小管的扫描电镜观察.上海口腔医学.2005,14(01)：48-50.
[53]Sengun A, Koyuturk AE, Sener Y, et al. Effect of desensitizers on the bond strength of a self-etching adhesive system to caries-affected dentin on the gingival wall. Oper Dent.2005,30(4):430-435.
[54]Soeno K, Taira Y, Matsumura H, et al. Effect of desensitizers on bond strength of adhesive luting agents to dentin. J Oral Rehabil.2001,28(12):1122-1128.
[55]Yim NH, Rueggeberg FA, Caughman WF, et al. Effect of dentin desensitizers and cementing agents on retention of full crowns using standardized crown preparations. J Prosthet Dent.2000,83(4):459-465.
[56]Swift EJ, Lloyd AH, Felton DA. The effect of resin desensitizing agents on crown retention. J Am Dent Assoc.1997,128(2):195-200.
[57]Mausner IK. Effect of two dentinal desensitizing agents on retention of complete cast coping using four cements.1996,75:129-134.
[2]赵铱民.口腔修复学(第六版).北京：人民卫生出版社,2003：73-74.
[3]Bergenholtz G, Cox CF, Loesche WJ, et al. Bacterial leakage around dental restorations:its effect on the dental pulp. J Oral Pathol.1982,11(6):439-450.
[4]江南,朱梅,史久成.金属烤瓷修复的牙髓评价.牙体牙髓牙周病学杂志.2000,10(06)：347-348.
[5]Sengun A, Koyuturk AE, Sener Y, et al. Effect of desensitizers on the bond strength of a self-etching adhesive system to caries-affected dentin on the gingival wall. Oper Dent.2005,30(4):430-435.
[6]Yim NH, Rueggeberg FA, Caughman WF, et al. Effect of dentin desensitizers and cementing agents on retention of full crowns using standardized crown preparations. J Prosthet Dent.2000,83(4):459-465.
[7]Soeno K, Taira Y, Matsumura H, et al. Effect of desensitizers on bond strength of adhesive luting agents to dentin. J Oral Rehabil.2001,28(12):1122-1128.
[8]Nikaido T, Nakaoki Y, Ogata M, et al. The resin-coating technique. Effect of a single-step bonding system on dentin bond strengths. J Adhes Dent.2003,5(4): 293-300.
[9]陈锡平,王庆,毕玮.劲润(Hybrid Coat)治疗活髓牙全冠制备后牙本质过敏的临床研究.中国临床医学.2010,17(3)：432-433.
[10]Ayad F, Ayad N. Comparing the efficacy in providing instant relief of dentine hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchamark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride:A Three-day clinical study in Mississauga, Canada.2009:20,115-122.
[11]李启艳,汤颖聪,杨睿Fluor Protector和Prime&Bond NT粘接剂对牙本质过敏症的治疗.中国误诊学杂志.2005,5(5)：860-861.
[12]王雪,李金华,牟建钢.脱敏剂封闭牙本质小管的微结构特征及其对树脂粘接剂粘接强度的影响.华西口腔医学杂志.2008,26(3)：233-236.
[13]Shafiei F, Memarpour M. Effect of repeated use on dentin bond strength of two adhesive systems:all-in-one and one-bottle. Indian J Dent Res.2009,20(2): 180-184.
[14]Docimo R, Montesani L, Maturo P, et al. Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion:an eight-week clinical study in Rome, Italy. J Clin Dent.2009,20(1):17-22.
[15]Kleinberg I. SensiStat. A new saliva-based composition for simple and effective treatment of dentinal sensitivity pain. Dent Today.2002,21(12):42-47.
[16]Petrou I, Heu R, Stranick M, et al. A breakthrough therapy for dentin hypersensitivity:how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth. J Clin Dent.2009, 20(1):23-31.
[17]解保生,Dickens SH, Schumacher G两种牙本质粘接剂粘接界面的扫描电镜研究.四川大学学报(医学版).2003,34(2)：270-273.
[18]Suge T, Ishikawa K, Kawasaki A, et al. Effects of fluoride on the calcium phosphate precipitation method for dentinal tubule occlusion. J Dent Res.1995, 74(4):1079-1085.
[19]Pashley DH, Carvalho RM, Pereira JC, et al. The use of oxalate to reduce dentin permeability under adhesive restorations. Am J Dent.2001,14(2):89-94.
[20]Hara AT, Pimenta LA, Jr Rodrigues AL. Influence of cross-head speed on resin-dentin shear bond strength. Dent Mater.2001,17(2):165-169.
[21]Johnson GH, Lepe X, Bales DJ. Crown retention with use of a 5% glutaraldehyde sealer on prepared dentin. J Prosthet Dent.1998,79(6):671-676.
[22]Cheng JT, Itoh K, Kusunoki M, et al. Effect of dentine conditioners on the bonding efficacy of one-bottle adhesives. J Oral Rehabil.2005,32(1):28-33.
[23]Wolfart S, Linnemann J, Kern M. Crown retention with use of different sealing systems on prepared dentine. J Oral Rehabil.2003,30(11):1053-1061.
[24]Kent WA, Jr Shillingburg HT, Jr Duncanson MG. Taper of clinical preparations for cast restorations. Quintessence Int.1988,19(5):339-345.
[25]Swift EJ, Lloyd AH, Felton DA. The effect of resin desensitizing agents on crown retention. J Am Dent Assoc.1997,128(2):195-200.
[26]陈治清.口腔材料学(第3版).北京：人民卫生出版社,2002：134.
[27]Ermis RB, Gokay N. Effect of fluorosis on dentine shear bond strength of a self-etching bonding system. J Oral Rehabil.2003,30(11):1090-1094.
[28]刘文侠,郭庆泰,丁伟山.钴铬合金和陶瓷间粘结强度研究.口腔材料器械杂志.2005,14(1)：5-8.
[29]Capa N, Ozkurt Z, Canpolat C, et al. Shear bond strength of luting agents to fixed prosthodontic restorative core materials. Aust Dent J.2009,54(4): 334-340.
[30]张鸣雷,王景云,吴健.钻铬合金烤瓷冠与镍铬合金烤瓷冠的临床使用效果比较与分析.吉林医学.2007,28(9)：1093-1094.
[31]孙平,盛祖立,张正仪.4种临床用烤瓷合金材料细胞毒性研究.口腔医学.2004,24(6)：344-346.
[32]巢永烈,刘长虹,李宁.牙用烤瓷支架钴铬钼合金的研制及机械性能的测试.华西口腔医学杂志.2005,23(1)：17-20.
[33]杨晓喻,刘长虹,巢永烈.牙用烤瓷支架钴铬钼合金热膨胀系数的测定.广东牙病防治.2006,14(2)：114-115.
[34]赵三军.牙本质粘接效果的评价方法及影响因素.国外医学.口腔医学分册.2002,29(5)：292-294.
[35]Scherrer S, Cesar PF, Swain MV. Direct comparison of the bond strength results of the different test methods:a critical literature review. Dent Mater.2010, 26(2):78-93.
[36]Camps J, Martin P, Ladeque P, et al. Influence of tooth cryopreservation on human dentin permeability, in vitro. Dent Mater.1994,10(3):210-214.
[37]Habelitz S, Jr Marshall GW, Balooch M, et al. Nanoindentation and storage of teeth. J Biomech.2002,35(7):995-998.
[38]Dahl B, Oilo G. Retentive properties of luting cements:an in vitro investigation. Dent Mater.1986,2(1):17-20.
[39]Diaz-Arnold AM, Vargas MA, Haselton DR. Current status of luting agents for fixed prosthodontics. J Prosthet Dent.1999,81(2):135-141.
[40]陈新民,王劲茗,孙俊.不同粘接剂的粘接力与机械嵌合力在金属全冠固位中的作用.华西医科大学学报.2001,32(2)：260-263.
[41]凌晨MS Coat脱敏剂对牙体预备后基牙牙本质敏感症疗效的研究：[硕士学位论文].成都：四川大学,2006.
[42]Mausner IK, Goldstein GR, Georgescu M. Effect of two dentinal desensitizing agents on retention of complete cast coping using four cements. J Prosthet Dent. 1996,75(2):129-134.
[43]Garcia-Godoy A, Garcia-Godoy F. Effect of an 8.0% arginine and calcium carbonate in-office desensitizing paste on the shear bond strength of composites to human dental enamel. Am J Dent.2010,23(6):324-326.
[44]游杰,周望梅.不同粘结剂对玻璃纤维桩与根管内牙本质粘结强度比较.广东医学.2009,30(09)：1317-1319.
[45]Burke FM, Lynch E. Glass polyalkenoate bond strength to dentine after chemomechanical caries removal. J Dent.1994,22(5):283-291.
[46]李苗健,张朋,秦红霞Gluma脱敏剂对黏接剂与牙本质间粘接力的作用.河南医学研究.2008,17(2)：146-148.
[1]江南,朱梅,史久成.金属烤瓷修复的牙髓评价.牙体牙髓牙周病学杂志.2000.6：347-348.
[2]赵铱民.口腔修复学(第六版).北京：人民卫生出版社,2003：73-74.
[3]Richardson D, Tao L, Pashley DH. Dentin permeability:effects of crown preparation. Int J Prosthodont.1991,4(3):219-225.
[4]张倩,程祥荣,何俐.全冠牙体预备后影响牙髓-牙本质复合体反应因素的研究.武汉大学学报(医学版).2005,3：355-358.
[5]Camps J, Dejou J, Remusat M, et al. Factors influencing pulpal response to cavity restorations. Dent Mater.2000,16(6):432-440.
[6]Zach L, Cohen G. Pulp response to externally applied heat. Oral Surg Oral Med Oral Pathol.1965,19:515-530.
[7]郑弟泽,牟雁东.冠修复牙体预备对髓腔温度影响的实验研究.华西口腔医学杂志.1998,16(3)：270-273.
[8]Christensen GJ. Tooth preparation and pulp degeneration. J Am Dent Assoc. 1997,128(3):353-354.
[9]Young HM, Smith CT, Morton D. Comparative in vitro evaluation of two provisional restorative materials. J Prosthet Dent.2001,85(2):129-132.
[10]Ogawa T, Aizawa S, Tanaka M, et al. Effect of water temperature on the fit of provisional crown margins during polymerization. J Prosthet Dent.1999,82(6): 658-661.
[11]Castelnuovo J, Tjan AH. Temperature rise in pulpal chamber during fabrication of provisional resinous crowns. J Prosthet Dent.1997,78(5):441-446.
[12]Murray PE, Hafez AA, Smith AJ, et al. Identification of hierarchical factors to guide clinical decision making for successful long-term pulp capping. Quintessence Int.2003,34(1):61-70.
[13]Rosenstiel SF, Land MF, Crispin BJ. Dental luting agents:A review of the current literature. J Prosthet Dent.1998,80(3):280-301.
[14]陈治清.口腔材料学(第3版).北京：人民卫生出版社,2002：134.
[15]White SN. Adhesive cements and cementation. J Calif Dent Assoc.1993,21(6): 30-37.
[16]Hegarty D, Macfarlane T. In vivo bracket retention comparison of a resin-modified glass ionomer cement and a resin-based bracket adhesive system after a year. Am J Orthod Dentofacial Orthop.2002,121(5):496-501.
[17]郑庄,唐亮.粘接材料与口腔固定修复的微渗漏(讲座).暨南大学学报(自然科学与医学版).2003(04)：111-114.
[18]许凌云,曾利伟.4种黏接剂对全瓷颈缘和合金颈缘的金属烤瓷冠微渗漏影响的对比研究.广东牙病防治.2008,16(06)：266-268.
[19]朱镇,王景云.修复体边缘微漏的影响因素及控制办法.口腔颌面修复学杂志.2002,3(02)：127-129.
[20]Lindquist TJ, Connolly J. In vitro microleakage of luting cements and crown foundation material. J Prosthet Dent.2001,85(3):292-298.
[21]Piwowarczyk A, Lauer HC, Sorensen JA. Microleakage of various cementing agents for full cast crowns. Dent Mater.2005,21(5):445-453.
[22]Orchardson R, Gillam DG. Managing dentin hypersensitivity. J Am Dent Assoc. 2006,137(7):990-998.
[23]Irvine JH. Root surface sensitivity:a review of aetiology and management. Soc Periodontol.1988,66:15-18.
[24]Orchardson R, Cadden SW. An update on the physiology of the dentine-pulp complex. Dent Update.2001,28(4):200-209.
[25]Chidchuangchai W, Vongsavan N, Matthews B. Sensory transduction mechanisms responsible for pain caused by cold stimulation of dentine in man. Arch Oral Biol.2007,52(2):154-160.
[26]于世凤.口腔组织病理学.北京：人民卫生出版社,2007：63.
[27]Pashley DH. Dynamics of the pulpo-dentin complex. Crit Rev Oral Biol Med. 1996,7(2):104-133.
[28]Brannstrom M, Astrom A. The hydrodynamics of the dentine; its possible relationship to dentinal pain. Int Dent J.1972,22(2):219-227.
[29]Rimondini L, Baroni C, Carrassi A. Ultrastructure of hypersensitive and non-sensitive dentine. A study on replica models. J Clin Periodontol.1995, 22(12):899-902.
[30]Dondi DG, Lone A, Finger WJ. Clinical evaluation of the role of glutardialdehyde in a one-bottle adhesive. Am J Dent.2002,15(5):330-334.
[31]Schupbach P, Lutz F, Finger WJ. Closing of dentinal tubules by Gluma desensitizer. Eur J Oral Sci.1997,105:414-421.
[32]Markowitz K, Bilotto G, Kim S. Decreasing intradental nerve activity in the cat with potassium and divalent cations. Arch Oral Biol.1991,36(1):1-7.
[33]Peacock JM, Orchardson R. Effects of potassium ions on action potential conduction in A- and C-fibers of rat spinal nerves. J Dent Res.1995,74(2): 634-641.
[34]Frechoso SC, Menendez M, Guisasola C, et al. Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial. J Clin Periodontol.2003,30(4): 315-320.
[35]任常群.牙本质过敏症的治疗进展.口腔医学纵横.2000,16(03)：232-233.
[36]Topbasi B, Turkmen C, Gunday M. An investigation of the effect of a desensitizing dentifrice on dentinal tubules in vitro and in vivo. Quintessence Int.1998,29(3):197-199.
[37]Kleinberg I. SensiStat. A new saliva-based composition for simple and effective treatment of dentinal sensitivity pain. Dent Today.2002,21(12):42-47.
[38]Petrou I, Heu R, Stranick M, et al. A breakthrough therapy for dentin hypersensitivity:how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth. J Clin Dent.2009, 20(1):23-31.
[39]Vieira AH, Santiago S L. Management of dentinal hypersensitivity. Gen Dent. 2009,57(2):120-126,127-128.
[40]Kern DA, Mcquade MJ, Scheidt MJ, et al. Effectiveness of sodium fluoride on tooth hypersensitivity with and without iontophoresis. J Periodontol.1989, 60(7):386-389.
[41]陈丽娟,祁惠兰,任长海.氟离子导入对牙本质小管封闭作用的实验研究.口腔医学.2007,27(02)：99-101.
[42]Leonard RH, Smith LR, Garland GE, et al. Desensitizing agent efficacy during whitening in an at-risk population. J Esthet Restor Dent.2004,16(1):49-56.
[43]Suge T, Kawasaki A, Ishikawa K, et al. Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion. Dent Mater.2008,24(2):192-198.
[44]Suge T, Kawasaki A, Ishikawa K, et al. Effect of ammonium hexafluorosilicate on dentin tubule occlusion for the treatment of dentin hypersensitivity. Am J Dent.2006,19(4):248-252.
[45]Arrais CA, Chan DC, Giannini M. Effects of desensitizing agents on dentinal tubule occlusion. J Appl Oral Sci.2004,12(2):144-148.
[46]Pillon F. Effect of a 3% potassium oxalate topical application on dentinal hypersensitivity after subgingival scaling and root planing.2004,75(11): 1464-1465.
[47]陆梅,高宁,岑远坤Gluma脱敏剂治疗活髓牙全冠牙体预备后敏感症的临床疗效和扫描电镜观察.口腔颌面修复学杂志.2006,7(04)：266-268.
[48]Cesar Augusto Galvao Arrais D C N C. Effect of desensitizing agents on dentinal tubule occlusion.2004,12(2):144-148.
[49]邢晓艳,刘士有,张青松Seal&Protect-(TM)对牙本质作用的扫描电镜研究.现代口腔医学杂志.2002,16(01)：28-29.
[50]王盼盼,陈新梅.3种家用脱敏剂阻塞牙本质小管的实验研究.国际口腔医学杂志.2010,37(05)：511-515.
[51]Nikaido T, Nakaoki Y, Ogata M, et al. The resin-coating technique. Effect of a single-step bonding system on dentin bond strengths. J Adhes Dent.2003,5(4): 293-300.
[52]潘鸣镝,黄轶锋.3种脱敏剂封闭牙本质小管的扫描电镜观察.上海口腔医学.2005,14(01)：48-50.
[53]Sengun A, Koyuturk AE, Sener Y, et al. Effect of desensitizers on the bond strength of a self-etching adhesive system to caries-affected dentin on the gingival wall. Oper Dent.2005,30(4):430-435.
[54]Soeno K, Taira Y, Matsumura H, et al. Effect of desensitizers on bond strength of adhesive luting agents to dentin. J Oral Rehabil.2001,28(12):1122-1128.
[55]Yim NH, Rueggeberg FA, Caughman WF, et al. Effect of dentin desensitizers and cementing agents on retention of full crowns using standardized crown preparations. J Prosthet Dent.2000,83(4):459-465.
[56]Swift EJ, Lloyd AH, Felton DA. The effect of resin desensitizing agents on crown retention. J Am Dent Assoc.1997,128(2):195-200.
[57]Mausner IK. Effect of two dentinal desensitizing agents on retention of complete cast coping using four cements.1996,75:129-134.