抗银药浴剂治疗寻常型血热型银屑病的临床及实验研究
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摘要
目的:观察抗银药浴剂治疗寻常型血热型银屑病的临床疗效,分析其对血液流变学及血浆内皮素的影响。
方法:纳入105例寻常型血热型银屑病患者,随机分为抗银药浴组(治疗组)和糠浴组(对照组),观察临床疗效。并检测用药前后血液流变学及血浆内皮素的变化。
结果
1.两组患者经治疗后症状、体征均有不同程度改善。治疗组总有效率为90.9%,对照组总有效率为76.0%,治疗组优于对照组,两组间差异具有显著统计学意义(P＜0.01)。
2.寻常型血热型银屑病各组与健康组血液流变学及血浆内皮素相比,差异有显著性。
3.两组血液流变学多项指标和血浆内皮素在治疗后均有下降,但治疗组比对照组下降程度更大,有显著性差异。
结论:抗银药浴剂对寻常型血热型银屑病的疗效较好;2.血液流变学多项指标与血浆内皮素在寻常型血热型银屑病患者中都有不同程度增高,其在银屑病发病中有重要意义。3.抗银药浴剂能相对显著的降低血液流变学多项指标与血浆内皮素,血液流变学及血浆内皮素的变化能反映寻常型银屑病病情程度的变化,可作为抗银药浴剂治疗寻常型血热型银屑病疗效观察的一个客观指标,是抗银药浴剂药理作用机制之一。
Objective:We want to observe the therapeutic effect on treatment of KangYin Bathe Lotion and effect on hemorheology and ET.
Methords:Randomly divided 105 cases of patients with Psoriasis Vulgaris of Blood-heat Type into treatment group(with KangYin Bathe Lotion),control group(with bran Bathe Lotion),observed clinic effect,detected the change of hemorheology and ET before and after treatment.
Results:There are different content improvement in symptom and physical sign after intervention in two groups.Total effect rate is 90.9 percent in treatment group,76.0 percent in control group.The effect rate of treatment group is better than the control group's.It is significant in statistics between two group(P＜0.01),
Conclusions:
1.It was better to treat Psoriasis Vulgaris of Blood-heat Type with KangYin Bathe Lotion.
2.Most index in hemorheology and ET were raise in varying degree,wich was important to Psoriasis Vulgaris.
3.KangYin Bathe Lotion could decrease most index in hemorheology and ET relatively significantly.Hemorheology and ET could reflet the change of pathogenetic condition of Psoriasis Vulgaris,as an objective index of the efficacy for KangYin Bathe Lotion treated Psoriasis Vulgaris,wich is one pharmaco-mechanism for it.
方法:纳入105例寻常型血热型银屑病患者,随机分为抗银药浴组(治疗组)和糠浴组(对照组),观察临床疗效。并检测用药前后血液流变学及血浆内皮素的变化。
结果
1.两组患者经治疗后症状、体征均有不同程度改善。治疗组总有效率为90.9%,对照组总有效率为76.0%,治疗组优于对照组,两组间差异具有显著统计学意义(P＜0.01)。
2.寻常型血热型银屑病各组与健康组血液流变学及血浆内皮素相比,差异有显著性。
3.两组血液流变学多项指标和血浆内皮素在治疗后均有下降,但治疗组比对照组下降程度更大,有显著性差异。
结论:抗银药浴剂对寻常型血热型银屑病的疗效较好;2.血液流变学多项指标与血浆内皮素在寻常型血热型银屑病患者中都有不同程度增高,其在银屑病发病中有重要意义。3.抗银药浴剂能相对显著的降低血液流变学多项指标与血浆内皮素,血液流变学及血浆内皮素的变化能反映寻常型银屑病病情程度的变化,可作为抗银药浴剂治疗寻常型血热型银屑病疗效观察的一个客观指标,是抗银药浴剂药理作用机制之一。
Objective:We want to observe the therapeutic effect on treatment of KangYin Bathe Lotion and effect on hemorheology and ET.
Methords:Randomly divided 105 cases of patients with Psoriasis Vulgaris of Blood-heat Type into treatment group(with KangYin Bathe Lotion),control group(with bran Bathe Lotion),observed clinic effect,detected the change of hemorheology and ET before and after treatment.
Results:There are different content improvement in symptom and physical sign after intervention in two groups.Total effect rate is 90.9 percent in treatment group,76.0 percent in control group.The effect rate of treatment group is better than the control group's.It is significant in statistics between two group(P＜0.01),
Conclusions:
1.It was better to treat Psoriasis Vulgaris of Blood-heat Type with KangYin Bathe Lotion.
2.Most index in hemorheology and ET were raise in varying degree,wich was important to Psoriasis Vulgaris.
3.KangYin Bathe Lotion could decrease most index in hemorheology and ET relatively significantly.Hemorheology and ET could reflet the change of pathogenetic condition of Psoriasis Vulgaris,as an objective index of the efficacy for KangYin Bathe Lotion treated Psoriasis Vulgaris,wich is one pharmaco-mechanism for it.
引文
[1]赵辨.临床皮肤病学.南京:江苏科学技术出版社,2001,762.
[2]国家中医药管理局.中华人民共和国中医药行业标准·中医皮肤病证诊断疗效标准,1995年1月1日实施.
[3]吴志华.现代.皮肤性病学[M].第1版.广州:广东人民出版社,2001,453.
[4]中医研究院广安门医院编.朱仁康临床经验集.北京:人民卫生出版社,1979:165-166.
[5]张志礼.张志礼皮肤病临床经验辑要[M].第1版.北京:中国医药科技出版社,1988.
[6]顾伯康.中医外科学[M].第1版.上海上海科学技术出版社1986.
[7]张小薇.在血论治寻常型银屑病8b例临床观察[J].北京中医杂志,1998,17(5):35.
[8]魏雅川,卢贺起.紫草鳖甲四物汤治疗162例银屑病临床观察[J].中医杂志,2000,41(2):97.
[9]张晓杰.寻常型银屑病辩证论治的研究.山东中医药大学学报.1997,21(2):110
[10]刘传华.复方槐米散治疗银屑病300例.陕西中医,1997,18(7):300.
[11]李宗明,孙小莉,等.克银膏治疗寻常型银屑病258例[J].上海中医药杂志,2003,37(4):41-42.
[12]王旭龙,叶平.复方牛蒡子油外治寻常型银屑病105例疗效观察[J].实用乡村医生杂志,2000,7(4):47.[13]
[13]姜光萍,李奕.硫化氢矿水加甘草全身浴治疗银屑病61例体会[J].新疆中医药,2001,19(2):14-15.
[14]孙姝,韩圣辉,原卉.中药药浴治疗寻常型银屑病84例临床观察[J].中国中医药科技,2004,11(2):81.
[15]闵仲生,王子雄,等.中药汽疗治疗寻常型银屑病71例临床及实验研究[J].江苏中医药,2002,23(8):12-14.
[16]杨利平.化银散熏吸治疗银屑病的临床观察[J].中西医结合杂志,1996,16(11):665.
[17]武艺,等.鱼腥草注射液治疗寻常型银屑病56例[J].吉林中医药,1999,6:34.
[18]董曼军.狼毒注射液治疗银屑病的临床研究[J].中华皮肤病杂志,1992,28(1):58.
[19]尚志黄.自血穴位注射治疗银屑病128例[J].山东中医杂志,1998,17(3):121.
[20]郑敏.银屑病是细胞免疾介导性疾病[J].中华皮肤科杂志,2002,35(2):85-87.
[21]GravenNM,JacksonCW,KirbyB,etal.Cytokinegenepolyor-phismsinpsoriasislJ2.BrJD ermatol,2001,144:849-853.
[22]孙建方.银屑病免疫学发病机制研究进展[J].青岛大学医学院学报,2001,37:1-21.
[23]石继海,鞠强,夏隆庆,等.银屑病发病机理的某些研究进展.国外医学皮肤性病学分册,2002,28:148-150.
[24]马成林.银屑病治疗进展.中国全科医学,2001,4:845-847.
[25]RaychaudhuriSRJAmAcadDermatol,1992,27:451-452.
[26]TakematsuHetal.BrJDermatol,1991,124:209-210.
[27]SkinnerRB,RosenbergW,NoahPW.Antimicrobialtreatmentofpso-riasis.DermatolClin,1995,13:909.
[28]BalagonMV,WalshDS,TanPL,etal.Improvementinpsoriasisafterintrodermaladministrat ionofheat_killedmycobacteriumvaccae.IntJdermatol,2000,39:51-58.
[29]刘跃华.银屑病的外用药物治疗[J].中国全科医学.2005,8(12):954-955.
[30]陈凯,蔡念宁.皮肤病中医特色治疗[M].沈阳:辽宁科学技术出版社,2001,191-192.
[31]YanagisawaM,KuriharaH,KimuraS,etal.Anovelpotentvasoconstrictorpeptideproduced byvascularendothelialcells[J].Nature,1988,332(6163):41-42.
[32]VanBockxmeerFM,MamotteCD,VasicananSD,etal.Methylen-etetrahydrofolate redoctase gene and coronary artery diesea.Circalation,1997,95:21-23.
[33]曹越兰,卢兴国,孙国均,周君富.银屑病患者血栓调节蛋白及血液流变学检测[J].中华皮肤科杂志,2000,4(33):113.
[34]YanagisawaM,KuriharaH,KimuraS,etal.Anovelpotentvasocon2strictorpeptideproduce dbyvascularendothelialcells[J].Nature,1988,332(6163):411-420.
[35]周萌,陶林昌.理血消银汤治疗银屑病临床疗效及对血浆内皮素的影响[J].中国中西医结合杂志,2005,25(10):929-931.
[36]赵生知.1016例劳动者血液流变学指标极其相关性疾病的分析.桂林医学院学报,1993,6:1.
[37]陈可冀,张之南,梁子钧.血瘀征与活血化瘀研究[M].上海:上海科技出版社,1990.488-494.
[38]蔡永敏,任玉让,王黎,等.中药药理与临床应用[M].北京华夏出版社,1999.67,75,88,103,278.
[39]路文璐,秦建中.17味中药对培养的表皮细胞增殖的影响[J].临床皮肤科杂志,1996,25(4):202.
[40]马清钧,王淑玲.常用中药现代研究与临床[M].天津:天津科技翻译出版公司,1995.102,111,129.
[41]王砚宁,毕新岭,顾军,等.黄芩治疗银屑病的研究[J].中国中西医结合皮肤性病学杂志,2003.2(4):209-211.
[2]国家中医药管理局.中华人民共和国中医药行业标准·中医皮肤病证诊断疗效标准,1995年1月1日实施.
[3]吴志华.现代.皮肤性病学[M].第1版.广州:广东人民出版社,2001,453.
[4]中医研究院广安门医院编.朱仁康临床经验集.北京:人民卫生出版社,1979:165-166.
[5]张志礼.张志礼皮肤病临床经验辑要[M].第1版.北京:中国医药科技出版社,1988.
[6]顾伯康.中医外科学[M].第1版.上海上海科学技术出版社1986.
[7]张小薇.在血论治寻常型银屑病8b例临床观察[J].北京中医杂志,1998,17(5):35.
[8]魏雅川,卢贺起.紫草鳖甲四物汤治疗162例银屑病临床观察[J].中医杂志,2000,41(2):97.
[9]张晓杰.寻常型银屑病辩证论治的研究.山东中医药大学学报.1997,21(2):110
[10]刘传华.复方槐米散治疗银屑病300例.陕西中医,1997,18(7):300.
[11]李宗明,孙小莉,等.克银膏治疗寻常型银屑病258例[J].上海中医药杂志,2003,37(4):41-42.
[12]王旭龙,叶平.复方牛蒡子油外治寻常型银屑病105例疗效观察[J].实用乡村医生杂志,2000,7(4):47.[13]
[13]姜光萍,李奕.硫化氢矿水加甘草全身浴治疗银屑病61例体会[J].新疆中医药,2001,19(2):14-15.
[14]孙姝,韩圣辉,原卉.中药药浴治疗寻常型银屑病84例临床观察[J].中国中医药科技,2004,11(2):81.
[15]闵仲生,王子雄,等.中药汽疗治疗寻常型银屑病71例临床及实验研究[J].江苏中医药,2002,23(8):12-14.
[16]杨利平.化银散熏吸治疗银屑病的临床观察[J].中西医结合杂志,1996,16(11):665.
[17]武艺,等.鱼腥草注射液治疗寻常型银屑病56例[J].吉林中医药,1999,6:34.
[18]董曼军.狼毒注射液治疗银屑病的临床研究[J].中华皮肤病杂志,1992,28(1):58.
[19]尚志黄.自血穴位注射治疗银屑病128例[J].山东中医杂志,1998,17(3):121.
[20]郑敏.银屑病是细胞免疾介导性疾病[J].中华皮肤科杂志,2002,35(2):85-87.
[21]GravenNM,JacksonCW,KirbyB,etal.Cytokinegenepolyor-phismsinpsoriasislJ2.BrJD ermatol,2001,144:849-853.
[22]孙建方.银屑病免疫学发病机制研究进展[J].青岛大学医学院学报,2001,37:1-21.
[23]石继海,鞠强,夏隆庆,等.银屑病发病机理的某些研究进展.国外医学皮肤性病学分册,2002,28:148-150.
[24]马成林.银屑病治疗进展.中国全科医学,2001,4:845-847.
[25]RaychaudhuriSRJAmAcadDermatol,1992,27:451-452.
[26]TakematsuHetal.BrJDermatol,1991,124:209-210.
[27]SkinnerRB,RosenbergW,NoahPW.Antimicrobialtreatmentofpso-riasis.DermatolClin,1995,13:909.
[28]BalagonMV,WalshDS,TanPL,etal.Improvementinpsoriasisafterintrodermaladministrat ionofheat_killedmycobacteriumvaccae.IntJdermatol,2000,39:51-58.
[29]刘跃华.银屑病的外用药物治疗[J].中国全科医学.2005,8(12):954-955.
[30]陈凯,蔡念宁.皮肤病中医特色治疗[M].沈阳:辽宁科学技术出版社,2001,191-192.
[31]YanagisawaM,KuriharaH,KimuraS,etal.Anovelpotentvasoconstrictorpeptideproduced byvascularendothelialcells[J].Nature,1988,332(6163):41-42.
[32]VanBockxmeerFM,MamotteCD,VasicananSD,etal.Methylen-etetrahydrofolate redoctase gene and coronary artery diesea.Circalation,1997,95:21-23.
[33]曹越兰,卢兴国,孙国均,周君富.银屑病患者血栓调节蛋白及血液流变学检测[J].中华皮肤科杂志,2000,4(33):113.
[34]YanagisawaM,KuriharaH,KimuraS,etal.Anovelpotentvasocon2strictorpeptideproduce dbyvascularendothelialcells[J].Nature,1988,332(6163):411-420.
[35]周萌,陶林昌.理血消银汤治疗银屑病临床疗效及对血浆内皮素的影响[J].中国中西医结合杂志,2005,25(10):929-931.
[36]赵生知.1016例劳动者血液流变学指标极其相关性疾病的分析.桂林医学院学报,1993,6:1.
[37]陈可冀,张之南,梁子钧.血瘀征与活血化瘀研究[M].上海:上海科技出版社,1990.488-494.
[38]蔡永敏,任玉让,王黎,等.中药药理与临床应用[M].北京华夏出版社,1999.67,75,88,103,278.
[39]路文璐,秦建中.17味中药对培养的表皮细胞增殖的影响[J].临床皮肤科杂志,1996,25(4):202.
[40]马清钧,王淑玲.常用中药现代研究与临床[M].天津:天津科技翻译出版公司,1995.102,111,129.
[41]王砚宁,毕新岭,顾军,等.黄芩治疗银屑病的研究[J].中国中西医结合皮肤性病学杂志,2003.2(4):209-211.