清肺平喘汤治疗小儿哮喘中度发作（热性哮喘）的临床观察
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摘要
目的
观察清肺平喘汤对小儿哮喘中度发作(热性哮喘)的临床疗效。
方法
本研究收集的病例来自湖南中医药大学第一附属医院门诊的患儿,选取的病例均符合小儿哮喘中度发作(热性哮喘)的诊断标准及此次临床观察的纳入标准。采用随机数字表将患儿分为治疗组和对照组各30例,治疗组予清肺平喘汤,日一剂,分早晚两2次温服,对照组予泼尼松片剂(强的松片5mg×100片河南天方药巡股份有限公司)2mg/kg·天,口服,分早、晚2次服用,沙丁胺醇片剂(硫酸沙丁胺醇片2.4mg×100粒常州康普药业有限公司)0.1mg/kg·次,Q8h,口服,治疗1周。观察治疗前、后患儿中医症状、体征及肺功能、外周血嗜酸性粒细胞计数的改变。
结果
经过治疗后,治疗组总有效率90.00%,高于对照组73.33%,经统计学处理有差异(P<0.05)。治疗后两组患儿症状积分、体征及肺功能、外周血嗜酸性粒细胞计数的改变均降低明显,与治疗前比较差异有统计学意义,(P<0.05)。
结论
治疗组可更有效地提高哮喘中度发作(热性哮喘)患儿的临床疗效、改善其临床症状。西医规范治疗予ABA(β2受体激动剂)加激素,初期效果较明显,但有愈后易复发及患者对激素依从性差等特点。中医予清肺平喘汤治疗后,患儿症状体征及肺功能、外周血嗜酸性粒细胞计数改善均优于对照组,且患儿依从性较好。
Objective:
Observation of Qingfei Pingchuan decoction on infantile asthma (moderate attack of asthma of heat type) clinical efficacy. Discussion on traditional Chinese medicine in the treatment of pediatric asthma acute attack period method. For traditional Chinese medicine in the treatment of pediatric asthma acute attack period to provide objective scientific basis and research method.
Material and method:
This study collected cases from the First Affiliated Hospital of Hunan University of Chinese Medicine outpatient clinic and consistent with the observed condition of60cases with moderate acute episode of infantile asthma (asthma of heat type) children, children were consistent with moderate acute episode of infantile asthma (asthma of heat type) diagnostic criteria and the clinical observation of inclusion criteria. The children were randomly divided into treatment group and control group with30cases in each group. The two groups in gender, age, course of disease and disease extent statistical significant difference. The treatment group to Qingfei antiasthmatic drink, day one agent, sooner or later two2lukewarm take, the control group received prednisone tablets (prednisone5mgx100Henan Tianfangyao Tour Company Limited)2mg/kg. Days, oral, early, late2doses, salbutamol sulfate tablets (sand salbutamol tablet2.4mgx100Changzhou Kangpu pharmaceutical limited company)0.1mg/kg, oral, three times a day, for1weeks. Observed before treatment, children with symptoms of traditional Chinese medicine, symptoms and pulmonary function, peripheral blood eosinophil count change.
Results:
After treatment in group two patients symptom scores were significantly lower, compared with before treatment had a significant difference (P<0.05). Two groups of patients after treatment, the treatment group total effective rate of90%, higher than that of control group73.33%, statistically significant differences (P<0.05). In two groups before treatment of pulmonary function indices compared (P>0.05), two groups had no significant difference, with comparable. After treatment of indexes were improved (P<0.05), compared with before treatment has significant difference. After treatment between the two groups there was significant difference (P<0.05). The results showed that the two groups were able to improve pulmonary function of patients, the treatment group was superior to control group.
Conclusion:
The treatment group than in the control group can be more effective to improve pediatric asthma (moderate attack of asthma of heat type) in effect, improve clinical symptoms. Western medicine treatment to ABA (beta2agonists) plus hormone, the initial effect is obvious, but there are more easily after the recurrence and patients with poor compliance of hormone characteristics. Traditional Chinese medicine in this respect has an advantage, to antiasthmatic Decoction in treating pediatric asthma lung (moderate attack of asthma of heat type) in children, in children with signs and symptoms and lung function, peripheral blood eosinophil counts were improved better than that of the control group, and the patients compliance is good.
观察清肺平喘汤对小儿哮喘中度发作(热性哮喘)的临床疗效。
方法
本研究收集的病例来自湖南中医药大学第一附属医院门诊的患儿,选取的病例均符合小儿哮喘中度发作(热性哮喘)的诊断标准及此次临床观察的纳入标准。采用随机数字表将患儿分为治疗组和对照组各30例,治疗组予清肺平喘汤,日一剂,分早晚两2次温服,对照组予泼尼松片剂(强的松片5mg×100片河南天方药巡股份有限公司)2mg/kg·天,口服,分早、晚2次服用,沙丁胺醇片剂(硫酸沙丁胺醇片2.4mg×100粒常州康普药业有限公司)0.1mg/kg·次,Q8h,口服,治疗1周。观察治疗前、后患儿中医症状、体征及肺功能、外周血嗜酸性粒细胞计数的改变。
结果
经过治疗后,治疗组总有效率90.00%,高于对照组73.33%,经统计学处理有差异(P<0.05)。治疗后两组患儿症状积分、体征及肺功能、外周血嗜酸性粒细胞计数的改变均降低明显,与治疗前比较差异有统计学意义,(P<0.05)。
结论
治疗组可更有效地提高哮喘中度发作(热性哮喘)患儿的临床疗效、改善其临床症状。西医规范治疗予ABA(β2受体激动剂)加激素,初期效果较明显,但有愈后易复发及患者对激素依从性差等特点。中医予清肺平喘汤治疗后,患儿症状体征及肺功能、外周血嗜酸性粒细胞计数改善均优于对照组,且患儿依从性较好。
Objective:
Observation of Qingfei Pingchuan decoction on infantile asthma (moderate attack of asthma of heat type) clinical efficacy. Discussion on traditional Chinese medicine in the treatment of pediatric asthma acute attack period method. For traditional Chinese medicine in the treatment of pediatric asthma acute attack period to provide objective scientific basis and research method.
Material and method:
This study collected cases from the First Affiliated Hospital of Hunan University of Chinese Medicine outpatient clinic and consistent with the observed condition of60cases with moderate acute episode of infantile asthma (asthma of heat type) children, children were consistent with moderate acute episode of infantile asthma (asthma of heat type) diagnostic criteria and the clinical observation of inclusion criteria. The children were randomly divided into treatment group and control group with30cases in each group. The two groups in gender, age, course of disease and disease extent statistical significant difference. The treatment group to Qingfei antiasthmatic drink, day one agent, sooner or later two2lukewarm take, the control group received prednisone tablets (prednisone5mgx100Henan Tianfangyao Tour Company Limited)2mg/kg. Days, oral, early, late2doses, salbutamol sulfate tablets (sand salbutamol tablet2.4mgx100Changzhou Kangpu pharmaceutical limited company)0.1mg/kg, oral, three times a day, for1weeks. Observed before treatment, children with symptoms of traditional Chinese medicine, symptoms and pulmonary function, peripheral blood eosinophil count change.
Results:
After treatment in group two patients symptom scores were significantly lower, compared with before treatment had a significant difference (P<0.05). Two groups of patients after treatment, the treatment group total effective rate of90%, higher than that of control group73.33%, statistically significant differences (P<0.05). In two groups before treatment of pulmonary function indices compared (P>0.05), two groups had no significant difference, with comparable. After treatment of indexes were improved (P<0.05), compared with before treatment has significant difference. After treatment between the two groups there was significant difference (P<0.05). The results showed that the two groups were able to improve pulmonary function of patients, the treatment group was superior to control group.
Conclusion:
The treatment group than in the control group can be more effective to improve pediatric asthma (moderate attack of asthma of heat type) in effect, improve clinical symptoms. Western medicine treatment to ABA (beta2agonists) plus hormone, the initial effect is obvious, but there are more easily after the recurrence and patients with poor compliance of hormone characteristics. Traditional Chinese medicine in this respect has an advantage, to antiasthmatic Decoction in treating pediatric asthma lung (moderate attack of asthma of heat type) in children, in children with signs and symptoms and lung function, peripheral blood eosinophil counts were improved better than that of the control group, and the patients compliance is good.
引文
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