高场磁共振下并行激发技术的相关研究
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摘要
磁共振成像技术是一种非介入式探测技术,有着能够反映诸多结构功能等生理差异与变化的多重对比机制,在当今的临床诊断和医学研究中有着极其重要的意义。自磁共振成像技术应用以来,为满足人们对成像高分辨率、高信噪比的需求,扫描仪的主磁场场强不断提升,对应的射频脉冲载波频率也随之提高。其结果是短波长的射频场与负载的耦合效应增强,导致射频能量在空间上的不均匀传递、从而对空间内质子的不均匀激发。作为磁共振信号源的质子激发的不均匀性的直接后果是,成像结果不能准确反映其真实信息,从而无法提供用于临床诊断和研究的可靠参照。针对该问题,本文以实现高场下射频场的不均匀性补偿、从而快速高质量成像为目标,从激发脉冲序列设计、线圈阵列的结构设计和实际K空间轨迹测量这三个方面展开研究工作。
     (1)关于激发脉冲序列设计
     为实现高场下三维目标区域内质子的均匀快速激发,提出了一种基于并行激发技术的激发脉冲序列的优化设计方法。该方法通过优化K空间轨迹的设计来优化脉冲序列时长、激发效果以及临床安全性,并已经高场下的建模仿真验证了其有效性。
     更具体的,该方法通过寻找优化的方式来限定K空间轨迹的分布范围、定义对K空间内的欠采样,来缩短脉冲序列时长;由于该方法所定义的K空间轨迹分布范围与激发目标特定相关,因此对于在该分布范围内采样的K空间轨迹、针对性的设计射频脉冲即能保证实现期望的激发效果;此外,该方法放开了对于三维K空间轨迹类型选择的限制,允许在设计中选择最优轨迹类型来减小激发所需射频脉冲的幅值与能量,从而提升了临床安全性。
     (2)关于线圈阵列的结构设计
     为在保证成像质量前提下充分发挥三维并行激发技术的加速作用,提出了一种用于并行激发技术第三维激发加速的线圈阵列的初步设计方法与评估方法。此前尚未有关于第三维扩展的线圈阵列的报道,是由本文首次提出的创新设计,因此在设计中借鉴了用于磁共振并行成像技术的线圈阵列的设计思路。经高场下的建模仿真验证了该设计方法与评估方法的有效性。启用此类线圈阵列作为发射线圈,结合以本文提出的用于三维空间选择性激励的序列设计方法,能够有效的缩短激发脉冲序列时长,从而提高成像时间分辨率
     (3)关于实际K空间轨迹测量
     为确保并行激发脉冲序列对目标区域质子的准确激发,研究了用于解决激发K空间轨迹形变问题的实际K空间轨迹测量方法。在永磁磁共振扫描仪上实验测试了经典的序列方式测量方法,结合理论与实验分析其优缺点,并通过将实际测得的K空间轨迹与理想轨迹进行成像重建的结果比较,验证了序列方式测量方法的有效性。
Magnetic resonance imaging (MRI), with its excellent soft tissue contrast, non-invasive character, is a promising medical imaging technique used in radiology to visualize internal structures and functions of the body in detail. However, the process of MRI formation introduces various artifacts that may corrupt a truly quantitative evaluation. One of major artifacts stems from the intra-slice intensity non-uniformity due to severe radio-frequency (RF) inhomogeneity in high field or ultra high field MRI, since the RF field propagating through the object has shorter wavelengths and greater attenuation, which induces unwanted intensity variations of the signal. This problem will be addressed throughout this thesis, by researching in transmit pulse sequence design, coil array design, and K-space trajectory measurement.
     (1) Transmit pulse sequence design
     Based on recently-developed parallel transmission techniques, an optimized3D tailored RF (TRF) pulse, designed with a novel3D adaptive trajectory, is proposed to improve and accelerate volume selective excitation. The feasibility of this method is confirmed by simulations of ultra-high field cases.
     There are three key factors concerning a practical use of a transmit pulse sequence: excitation uniformity, pulse duration, and RF energy relating to clinical safety issues. The method optimally defines the k-space trajectory to improve all of the three key factors.
     In detail, the method dedicatedly defines and limits the traversing area of the k-space trajectory, to find an appropriate way to subsample the k-space, so as to shorten the pulse duration. The dedicatedly defined traversing area is supposed to be mostly responsible for the excitation target, so that a promising uniform excitation can be achieved in the target region. Moreover, because the method allows designer to introduce various types of3D k-space trajectory, one can optimally choose one type to help reduce the peak RF pulse amplitude and the entire energy for the excitation, so as to improve RF safety margins in clinical applications.
     (2) Coil array design
     A brand new type of coil array geometry is proposed for3D parallel excitation. Such geometry is expected to be used to explore excitation acceleration in an extra dimension, compared to the conventional transmit coil array, so that to mitigate degradation in excitation accuracy at high acceleration factors. Similar type of coil array geometry specialized for parallel imaging is used as reference for those for parallel excitation. The performance of the proposed coil array geometry is demonstrated via simulation based comparison, showing its ability to adapt the3D parallel transmit pulse sequence, to further accelerate excitation pulse length, and to improve excitation accuracy. An evaluation method is also proposed to assess the parallel excitation performance of coil array geometries.
     (3) K-space trajectory measurement
     Actual K-space trajectory measurement techniques was studied and their performance are tested on a permanent magnet scanner, in accounting for the deviations from the theoretical k-space trajectory and achieving accurate excitation of target pattern. The feasibility of the techniques is confirmed by comparisons of image reconstruction results based on the expected and the measured trajectories.
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