赵冠英教授治疗慢性胃炎学术经验研究
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摘要
理论溯源:赵冠英教授长期从事中西医结合治疗慢性胃炎的研究,认为慢性胃炎属于中医学脾胃病中“胃脘痛”、“痞满”、“嘈杂”、“泛酸”的范畴,其病位在胃,病因主要为外邪侵袭、饮食不节、忧思郁怒以及脾胃虚弱等。现代医学认为病因主要有物理化学因素、幽门螺旋杆菌感染、胃动力障碍、胆汁返流、免疫因素、年龄、职业等。
学术经验:赵冠英教授在理论上强调人以胃气为本,治胃须遵循胃的生理特性、重视胃与脾、肝、肾三脏的关系,主张治胃先理脾、治胃必疏肝、治胃须补肾。在大量文献研究的基础上,结合长期的临床实践,将慢性胃炎病机特点概括为:虚实互见、寒热错杂、湿热互结、气血同病。病机性质多属本虚标实、虚实错杂。虚为胃气虚弱;实为肝气犯胃、湿热阻滞、气滞血瘀。初病在经属气,久病入络属血。治疗上创立健脾和胃、清胃泻火、辛开苦降、消食导滞、平肝降逆、疏胆和胃、酸甘养阴、化瘀通络等八法。并根据此学术观点,创制了参柴黄连汤治疗慢性胃炎,经长期临床应用,疗效显著。临证时主张中西结合、辨证与辨病相结合;重视察舌诊病;通过中医辨证与胃镜下粘膜相结合,初步将本病分为脾胃虚弱、肝胃不和、脾胃湿热、胃阴不足、胃络瘀滞等五型施治;注意预防调摄,调畅情志,饮食有节和适度运动。
临床研究:通过参柴黄连汤治疗慢性胃炎的临床研究,发现该方能显著改善慢性胃炎患者的临床症状、胃镜征象和舌象,抑制或杀灭Hp,对萎缩性胃炎的肠化生和异型增生也有一定的逆转和治疗作用,从而降低或阻断萎缩性胃炎的癌变可能。对于舌苔的改善优于舌质的改善,对于浅袁性胃炎的作用优于萎缩性胃炎。从药理作用分析,疗效可能与增强免疫,保护胃粘膜,改善胃粘膜微循环,抗菌消炎,杀灭Hp,调节胃肠运动,促进胃动力,解痉止痛,增加胃酸,抑制癌前病变等环节有关。
用药规律和经验研究:收集和整理导师治疗慢性胃炎116张资料完整的初诊处方,运用频率分析的方法,整理和总结导师治疗慢性胃炎的用药规律和经验,发现导师治疗慢性胃炎所用中药基本为43种,最常用的药物为党参、白术、茯苓、炙甘草、乌药、白芍、吴茱萸、黄连等8种;较常用的药物是柴胡、枳壳、砂仁、生三仙、陈皮、蒲公英等15种。其它20种为治疗慢性胃炎一般常用药物。常用的方剂主要有四君子汤,左金丸、芍药甘草汤、四逆散、当归补血汤、良附丸、乌贝散。
Review: professor Zhao Guan-ying has been studying Chronic Gastritis(CG) with Chinese medicine and west medicine for a long time. CG belongs to the scope of "weiwantong", "piman", "caoza" and "fansuan" in Chinese medicine. It takes place in the stomach and is mainly caused by exogenous pathogens, improper diet, emotion, and weakness of spleen and stomach. While in west medicine it is regarded as causing mainly by the factors of physics and chemistry, Hp, obstacle of stomach movement, immunity, countercurrent of bile, and age,work and so on.
Experience of professor Zhao: the function of stomach-qi is very important. Treating stomach should obey to the character of stomach, attach the importance to the relationships among spleen, liver and kidney. Basing on the theory and clinical practise, he sum up the mechanism of CG as follow: coexistence of insufficiency and sufficiency, interveining of cold and heat, stagnation of damp-heat, dual disease of qi and blood. The essence of CG is insufficiency of the normal and excessiveness of the pathogenic. The weakness of stomach is the basis of CG, while liver-qi invading the stomach, stagnation of damp-heat, depression and stagnation of qi and blood are the secondary factors. Firstly it is in channels belonging to qi, finally it is in collaterals belonging to blood. Professor Zhao aslo invents 8 measures to treat CG Basing on the theory, he has founded the docotion Senchaihuangliantang(SCHLT) to treat CG, and its effect is remarkable. When treating patients he always pays attention to comibine Chinese medicine with west medicine, and syndrome differentiation with disease identification, and observe the tongue. By the means of syndromes and gastroscopy, he often divides CG into five syndrome patterns to treat. he also pays attention to preservation, emotion, diet and exercise.
Clinical Research: SCHLT can improve the symptoms of patients, tongue coating, and gastroscopy, kill Hp, treat and reverse IM and ATP, so it maybe lower or hinder the occurrence of cancer. It is better to improve tongue coating than tongue proper. It is better to treat in CSG than in CAG. It may take effect in such ways: improving the immunity and blood circulation, defending the stomach, killing Hp, regulating the movement of stomach, killing the pain, increasing the acid, preventing the occurrence of cancer.
Experience of durg usage: by frequency analysis with collection of 116 prescriptions, 43 drugs was found by which professor Zhao often gets used to dealing with CG. Such 8 drugs as Tangsheng, Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae Praeparata, White Peony Root Fructus Evodiae, Radix Linderae, Rhizoma Coptidis are most often used in the treatment of CG While other drugs as Thorowax Root,Orange Fruit, Fructus Amomi, Herba Taraxaci, Pericapium Charred Triplet are often used, and other 20 drugs are also used. Such prescriptions as Sijunzi Docotion, Zuojin Pill, Shaoyaogancao Docotion, Power for treating cold limbs, Liangfu Pill and Wubei Power are often used.
学术经验:赵冠英教授在理论上强调人以胃气为本,治胃须遵循胃的生理特性、重视胃与脾、肝、肾三脏的关系,主张治胃先理脾、治胃必疏肝、治胃须补肾。在大量文献研究的基础上,结合长期的临床实践,将慢性胃炎病机特点概括为:虚实互见、寒热错杂、湿热互结、气血同病。病机性质多属本虚标实、虚实错杂。虚为胃气虚弱;实为肝气犯胃、湿热阻滞、气滞血瘀。初病在经属气,久病入络属血。治疗上创立健脾和胃、清胃泻火、辛开苦降、消食导滞、平肝降逆、疏胆和胃、酸甘养阴、化瘀通络等八法。并根据此学术观点,创制了参柴黄连汤治疗慢性胃炎,经长期临床应用,疗效显著。临证时主张中西结合、辨证与辨病相结合;重视察舌诊病;通过中医辨证与胃镜下粘膜相结合,初步将本病分为脾胃虚弱、肝胃不和、脾胃湿热、胃阴不足、胃络瘀滞等五型施治;注意预防调摄,调畅情志,饮食有节和适度运动。
临床研究:通过参柴黄连汤治疗慢性胃炎的临床研究,发现该方能显著改善慢性胃炎患者的临床症状、胃镜征象和舌象,抑制或杀灭Hp,对萎缩性胃炎的肠化生和异型增生也有一定的逆转和治疗作用,从而降低或阻断萎缩性胃炎的癌变可能。对于舌苔的改善优于舌质的改善,对于浅袁性胃炎的作用优于萎缩性胃炎。从药理作用分析,疗效可能与增强免疫,保护胃粘膜,改善胃粘膜微循环,抗菌消炎,杀灭Hp,调节胃肠运动,促进胃动力,解痉止痛,增加胃酸,抑制癌前病变等环节有关。
用药规律和经验研究:收集和整理导师治疗慢性胃炎116张资料完整的初诊处方,运用频率分析的方法,整理和总结导师治疗慢性胃炎的用药规律和经验,发现导师治疗慢性胃炎所用中药基本为43种,最常用的药物为党参、白术、茯苓、炙甘草、乌药、白芍、吴茱萸、黄连等8种;较常用的药物是柴胡、枳壳、砂仁、生三仙、陈皮、蒲公英等15种。其它20种为治疗慢性胃炎一般常用药物。常用的方剂主要有四君子汤,左金丸、芍药甘草汤、四逆散、当归补血汤、良附丸、乌贝散。
Review: professor Zhao Guan-ying has been studying Chronic Gastritis(CG) with Chinese medicine and west medicine for a long time. CG belongs to the scope of "weiwantong", "piman", "caoza" and "fansuan" in Chinese medicine. It takes place in the stomach and is mainly caused by exogenous pathogens, improper diet, emotion, and weakness of spleen and stomach. While in west medicine it is regarded as causing mainly by the factors of physics and chemistry, Hp, obstacle of stomach movement, immunity, countercurrent of bile, and age,work and so on.
Experience of professor Zhao: the function of stomach-qi is very important. Treating stomach should obey to the character of stomach, attach the importance to the relationships among spleen, liver and kidney. Basing on the theory and clinical practise, he sum up the mechanism of CG as follow: coexistence of insufficiency and sufficiency, interveining of cold and heat, stagnation of damp-heat, dual disease of qi and blood. The essence of CG is insufficiency of the normal and excessiveness of the pathogenic. The weakness of stomach is the basis of CG, while liver-qi invading the stomach, stagnation of damp-heat, depression and stagnation of qi and blood are the secondary factors. Firstly it is in channels belonging to qi, finally it is in collaterals belonging to blood. Professor Zhao aslo invents 8 measures to treat CG Basing on the theory, he has founded the docotion Senchaihuangliantang(SCHLT) to treat CG, and its effect is remarkable. When treating patients he always pays attention to comibine Chinese medicine with west medicine, and syndrome differentiation with disease identification, and observe the tongue. By the means of syndromes and gastroscopy, he often divides CG into five syndrome patterns to treat. he also pays attention to preservation, emotion, diet and exercise.
Clinical Research: SCHLT can improve the symptoms of patients, tongue coating, and gastroscopy, kill Hp, treat and reverse IM and ATP, so it maybe lower or hinder the occurrence of cancer. It is better to improve tongue coating than tongue proper. It is better to treat in CSG than in CAG. It may take effect in such ways: improving the immunity and blood circulation, defending the stomach, killing Hp, regulating the movement of stomach, killing the pain, increasing the acid, preventing the occurrence of cancer.
Experience of durg usage: by frequency analysis with collection of 116 prescriptions, 43 drugs was found by which professor Zhao often gets used to dealing with CG. Such 8 drugs as Tangsheng, Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae Praeparata, White Peony Root Fructus Evodiae, Radix Linderae, Rhizoma Coptidis are most often used in the treatment of CG While other drugs as Thorowax Root,Orange Fruit, Fructus Amomi, Herba Taraxaci, Pericapium Charred Triplet are often used, and other 20 drugs are also used. Such prescriptions as Sijunzi Docotion, Zuojin Pill, Shaoyaogancao Docotion, Power for treating cold limbs, Liangfu Pill and Wubei Power are often used.
引文
[1]陈灏珠,丁训杰,廖履坦,等.实用内科学,人民卫生出版社.2003年,第11版:1737.
[2]刘为纹.Hp与胃癌.中华消化杂志.1993,13(2):100.
[3]PERRY HM.Chronic gastritis with associated superficial erosions.Guthrie Clin Bull,1988,28(2):40-45.
[4]柴可夫.慢性胃炎.科学技术文献出版社,2000年,第2版:19.
[5]胡伏莲,周殿元,主编.幽门螺旋杆菌感染的基础和临床.中国科学技术出版社.2002年,第1版:24.
[6]Goodwin CS.Duodenal ulcer,Campylobacter pylori,and the "leaking roof" concept.Lancet,1988,2:1467-1469.
[7]Levis,Beardshall K,Haddda G;etal.Pathogensis and virulence factors of Helicobacter pylori.Gurr Opin Gastroenterol,1999,15:s11-16.
[8]Haruma K,KamadaT,Kawaguchi H,etal.Effect of age and Helicobacter pylori infection on gastric acid secretion.J Gastroenterol,2000;15:277-283.
[9]Keenan J,Allardyce.Iron influences the expression of Helico-bacter pylori outer membrane vesicle associated virulence factors.Eur J Gastroenterol Gepatol,2000;12:1267.
[10]Axon AT.Are all helicobacters equal Mechanisms of gastroduodenal pathology and their clinical implications.Gut,199945(suppl):11-14.
[11]Eaton KA,Morgan DR,Krakowka S.Motility as a factor in the coloni-sation of gnotobiotic Piglets by Helicobacter pyori.J Med Microbiol,1992;37:123-127.
[12]Leunk RD,Johnson PT,David BC,et al.Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.)Med Microbiol,1988;26:93-99.
[13]Sarosiek J,Bilski J,Murty VL,et al.Cloolidal bismuth subcitrat(De-NO1)inhibits degradation Protease.Am J Gastroenterol,1989,84:506-510.
[14]Marshall BJ,Helicobacter pylori Am J Gastroenterol 1994:89(8Suppl)S116-S128,of gastric mucus by Campylobacter pylori.
[15]张燕梅.思伤脾与脑肠肽.中国中医基础医学杂志.2000,6(1):6-7.
[16]国家中医药管理局.中医病证诊断疗效标准.南京大学出版社,1994年第1版: 9.
[17]郑筱萸,主编.中药新药临床研究指导原则(第2辑).中国医药科技出版社.2002:124-127.
[18]中华医学会消化分会.中华消化杂志.2006,20(3):199-201.
[19]中华医学会消化分会.全国幽门螺旋杆菌会议共识意见(2003年,安徽桐城).中华消化杂志.2004,24(2):126.
[20]中国中西医结合学会.慢性胃炎中西医结合诊治方案(2003年,重庆).中国中西医结合杂志.2005,25(6):172-176.
[21]孙传兴,主编.临床疾病诊断依据治愈好转标准.人民军医出版社.1998年,第2版:72.
[22]罗开云.白花蛇舌草、半枝莲治疗慢性胃炎87例.中国中西医结合脾胃杂志.2000,8(2):116.
[23]沈映君主编.中药药理学.人民卫生出版社.2000年,第1版:955.
[24]周金黄.中药药理学.上海科学技术出版社.1986年,第1版:245.
[25]沈映君主编.中药药理学.人民卫生出版社.2000年,第1版:885.
[26]夏玉亭,吴云林,房殿春,主编.胃病诊治进展.上海科技教育出版社.2005年,第1版:33.
[27]张宝恒.乌拉尔甘草的抗炎作用.中草药.1991,22(10):542.
[28]脱守文.柴胡注射液对小鼠腹腔巨噬细胞表面FG受体的影响.中药药理与临床.1985,1(1).165.
[29]金航,张志军.汉方药对胃粘膜及胃动力的影响.国外医学中医中药分册.1997,19(2):19
[30]Hirano H,Osawa E,Yamaoka,etal.Gastric-mucous membrane protection activity of coptisine derivatives Biolpharm Bull,2001(11):1277.
[31]Shimiz K,etal.New derivatives of saiko saponins.Chem Pharm Bull,1985,33(8):3349.
[32]杨耀芳.白芍总甙对大鼠血小板聚集的影响.安徽中医学院学报.1993,12(1):51.
[33]徐建国,张梅涧.幽门弯曲菌的中药药敏实验.北京中医.1991,(4)52.
[34]马有度 主编.医方新解.上海科学技术出版社.1980年,第1版:46.
[35]王绪霖,缴稳玲,吕宗舜.抑制幽门螺杆菌中药的初步筛选.中国中西医结合脾胃杂志.1994,14(9):534.
[36]徐州,周德端,段国勋.中药对幽门螺杆菌抑杀作用的试验研究.中国医药学报.1993,8(5):281.
[37]张琳,杨连文,郑晓光,等.中药对空腹弯曲菌与门螺旋杆菌的抑制作用.中国中西医结合脾胃杂志.1994,2(1):32-33.
[38]王绪霖,缴稳玲,吕宗舜.抑制幽门螺杆菌中药的初步筛选.中国中西医结合脾胃杂志.1994,14(9):534.
[39]任平.四君子汤对脾虚模型大鼠胃泌素和前列腺素E_2含量的影响.中药药理与临床.1994,10(6):7.
[40]彭成.四君子汤对消化、运动、吸收的实验研究.中药药理与临床.1995,11(5):6.
[41]李贵海.枳壳挥发油含量对小鼠胃肠推进的影响.中药饮片.1993,(1):20.
[42]王浴生.中药药理与应用.人民卫生出版社.1983年,第1版:521.
[43]周金黄.中药药理学.上海科学技术出版社.1986年,第1版:113.
[44]李仪奎,王钦茂.中药药理实验方法学.上海科学技术出版社.1991年,第1版:300.
[45]雒明池.中医药治疗慢性萎缩性胃炎疗效分析.天津中医药.2007,24(8):281-282.
[46]江苏新医学院.中药大辞典(上).上海人民出版社.1977年,第1版:569.
[47]许长照.健脾药(四君子汤和茯苓汤)对Eca10g食管癌和肺鳞癌细胞分裂的影响.中药药理与临床.1985,(创刊号):15.
[48]李广勋.中药药理毒理与临床.天津科技翻译出版公司.1992年,第1版:448.
[49]高学敏,主编.中药学(中医药高级丛书).人民卫生出版社.2000年,第1版.
[50]周凤梧.古今方药纵横.人民卫生出版社.1987年,第1版:257.
[51]黄玲.党参川芎蒲公英及其配伍复方抗胃溃疡与抗胃粘膜损伤作用与机制研究.中药药理与临床.1991,7(5):10.
[52]王辉武.中药新用.科学技术文献出版社重庆分社.1986年,第1版:311.
[53]邓伟民,唐庚云,许鑫梅,等.消胀冲剂治疗慢性萎缩性胃炎的临床研究.中国中医药科技.1997,4(4):201.
[1]韩捷.张自平教授治疗慢性胃炎经验.光明中医.2007,22(5):24-25.
[2]朱梅萍,张正利,林江.蔡淦治疗慢性胃炎的临床经验.上海中医药杂志.2006,40(7):12-13.
[3]邓沂,崔庆荣,李金田,等.于己百诊治慢性胃炎经验.世界中医药.2006,1(1):30-31.
[4]方胜林.吴秋玲治疗慢性胃炎经验.四川中医.2006,24(12):5-6.
[5]裴林,李刚,顾洁.李佃贵教授治疗慢性胃炎经验介绍.新中医.2007,39(3):13-14.
[6]张声生,牧童,汪红兵,等.慢性浅表性胃炎证候分布的研究.中华中医药杂志.2007,22(1):18-21.
[7]卢成孝.辨证治疗慢性浅表性胃炎80例.实用中医内科杂志.2007,21(3):
[8]黄雪萍.辨证治疗慢性浅表性胃炎54例.实用中医内科杂志.2006,20(3):254-255.
[9]卫永琪.辨证治疗慢性浅表性胃炎81例.实用中医药杂志.2005,21(1):12-13.
[10]方东行.治疗慢性浅表性胃炎的体会.时珍国医国药.2001,12(5):443.
[11]于建文.山西中医.辨证治疗浅表性胃炎.2005,21(3):25.
[12]郑建民.半夏泻心汤治疗慢性浅表性胃炎180例.浙江中西医结合杂志.2005,15(10):647-648.
[13]刘建吉.柴胡桂枝汤治疗慢性浅表性胃炎临床研究.中外健康文摘.2007,4(6):659-660.
[14]朱晓,王霞.加味六君子汤治疗慢性浅表性胃炎临床观察.潍坊医学院学报.2006,28(1):45-46.
[15]胡志明,曾玉芬.湖南中医杂志.天台乌药散治疗慢性浅表性胃炎65例.22(5):53-54.
[16]王钢,刘红玉.温胆汤加减方治疗慢性浅表性胃炎58例.现代中西医结合杂志.2004 13(3):315-316.
[17]何剑荣,魏卓红.和胃调肝胶囊治疗慢性浅表性胃炎200例疗效观察.新中医.2007,39(7):29-30.
[18]王树桂,朱敏嘉.胃力康颗粒剂治疗慢性浅表性胃炎100例临床观察.广西医学.2005,27(9):1407-1408.
[19]李颖,辛素文,孙吉华.调胃颗粒治疗慢性浅表性胃炎的临床与实验研究.湖北中医杂志.2002,24(6):27-28.
[20]欧琴,何坚.中西医结合治疗肝气郁结型慢性浅表性胃炎临床观察.广西中医药.2002,25(6):15-16.
[21]马孝义.中西医结合治疗慢性浅表性胃炎56例.天津中医药.2006,23(5):412.
[22]宋建宁,陈庆龄.穴位注射、针刺治疗慢性浅表性胃炎70例疗效比较.福建医学.2002,24(5):16.
[23]辛银虎,陈小玲.温针治疗脾胃虚寒型慢性浅表性胃炎52例.陕西中医.2005,26(9):959-960.
[24]洪钰芳,李虹虹,秦亮甫.针药结合治疗慢性胃炎90例临床观察.上海针灸杂志.2005,24(9):21-22.
[1]杨丽华,杨戈,马春.活血化瘀法在慢性萎缩性胃炎治疗中的作用.吉林中医药.2006,26(3):16.
[2]陈允旺.益气活血法治疗慢性萎缩性胃炎之浅识.陕西中医.2006,27(5):638-640.
[3]王禄.治疗慢性萎缩性胃炎的体会.中医研究.2005,18(10):59.
[4]张竞之,吴伟伟,涂志红.涂福音教授治疗慢性萎缩性胃炎的经验.河南中医.2005,25(11):15-16.
[5]李儒文.慢性萎缩性胃炎辨治的思路和方法.吉林中医药.2006,26(2):12-13.
[6]邱绮玉,章菊花.舌脉诊对中医药治疗慢性萎缩性胃炎的临床指导意义.湖北中医学院学报.2000,2(4):37.
[7]柯莹玲,单兆伟.542例慢性萎缩性胃炎患者中医辨证分型与病因分析.辽宁中医杂志.2006,32(2):161.
[8]顾缨,单兆伟.单兆伟教授治疗慢性萎缩性胃炎经验.南京中医药大学学报.2005,21(3):184.
[9]苑述刚.滋阴益气法治疗慢性萎缩性胃炎103例.中医药学刊.2005,26(10):1766-1767.
[10]柯莹玲,单兆伟.辨证治疗慢性萎缩性胃炎癌前病变患者78例.上海中医药大学学报.2005,19(4):18-20.
[11]陈良金.慢性萎缩性胃炎辨证分型与证候特点探析.时珍国医国药.2005,16(11):1149.
[12]游涛,徐淑静.慢性萎缩性胃炎的中医辨治体会.吉林中医药.2006,26(3):29-30.
[13]杨锦侠,张升良,杨小丽.滋阴益气法治疗慢性萎缩性胃炎103例.现代中医药.2006,26(53):11-12.
[14]陈一斌.益胃汤治疗慢性萎缩性胃炎60例.河南中医.2006,26(3):34.
[15]丁静.清炎益胃汤治疗慢性萎缩性胃炎30例.吉林中医药,2006,26(5):16.
[16]练慧,张正利.柴胡疏肝散合四君子汤治疗慢性萎缩性胃炎47例.上海中医药 杂志.2006,40(5):27-28.
[17]史海霞,胡运莲.加味左金丸治疗慢性萎缩性胃炎临床研究.湖北中医杂志.2007,29(1):34.
[18]蔡锦莲,李爱娣,曾兰英.萎胃散治疗慢性萎缩性胃炎临床研究.河南中医.2006,26(5):28-30.
[19]卓玉珍,袁红梅,王学,等.善胃方对慢性萎缩性胃炎患者P_(16)蛋白的影响.天津中医药.2006,23(1):61-63.
[20]刘启泉,王志坤,白海燕.胃安颗粒治疗慢性萎缩性胃炎合并消化性溃疡临床观察.辽宁中医杂志.2005,32(12):1265-1266.
[21]胡俊铭.健胃汤治疗慢性萎缩性胃炎的临床观察.湖北中医学院学报杂志.2002,4(3):42.
[22]董崇海,曲玲,王有广,等.安中舒胃汤联合亚硒酸钠治疗慢性萎缩性胃炎的临床研究.中医药学报.2006,34(1):44-46.
[23]孙玉霞,李苏民.针灸治疗慢性萎缩性胃炎30例.陕西中医.2005,26(9):955.
[24]谢文霞,曹高忠,朱启槐,等.电针加穴位注射治疗慢性萎缩性胃炎35例.浙江中医杂志.2005,40(9):401.
[2]刘为纹.Hp与胃癌.中华消化杂志.1993,13(2):100.
[3]PERRY HM.Chronic gastritis with associated superficial erosions.Guthrie Clin Bull,1988,28(2):40-45.
[4]柴可夫.慢性胃炎.科学技术文献出版社,2000年,第2版:19.
[5]胡伏莲,周殿元,主编.幽门螺旋杆菌感染的基础和临床.中国科学技术出版社.2002年,第1版:24.
[6]Goodwin CS.Duodenal ulcer,Campylobacter pylori,and the "leaking roof" concept.Lancet,1988,2:1467-1469.
[7]Levis,Beardshall K,Haddda G;etal.Pathogensis and virulence factors of Helicobacter pylori.Gurr Opin Gastroenterol,1999,15:s11-16.
[8]Haruma K,KamadaT,Kawaguchi H,etal.Effect of age and Helicobacter pylori infection on gastric acid secretion.J Gastroenterol,2000;15:277-283.
[9]Keenan J,Allardyce.Iron influences the expression of Helico-bacter pylori outer membrane vesicle associated virulence factors.Eur J Gastroenterol Gepatol,2000;12:1267.
[10]Axon AT.Are all helicobacters equal Mechanisms of gastroduodenal pathology and their clinical implications.Gut,199945(suppl):11-14.
[11]Eaton KA,Morgan DR,Krakowka S.Motility as a factor in the coloni-sation of gnotobiotic Piglets by Helicobacter pyori.J Med Microbiol,1992;37:123-127.
[12]Leunk RD,Johnson PT,David BC,et al.Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.)Med Microbiol,1988;26:93-99.
[13]Sarosiek J,Bilski J,Murty VL,et al.Cloolidal bismuth subcitrat(De-NO1)inhibits degradation Protease.Am J Gastroenterol,1989,84:506-510.
[14]Marshall BJ,Helicobacter pylori Am J Gastroenterol 1994:89(8Suppl)S116-S128,of gastric mucus by Campylobacter pylori.
[15]张燕梅.思伤脾与脑肠肽.中国中医基础医学杂志.2000,6(1):6-7.
[16]国家中医药管理局.中医病证诊断疗效标准.南京大学出版社,1994年第1版: 9.
[17]郑筱萸,主编.中药新药临床研究指导原则(第2辑).中国医药科技出版社.2002:124-127.
[18]中华医学会消化分会.中华消化杂志.2006,20(3):199-201.
[19]中华医学会消化分会.全国幽门螺旋杆菌会议共识意见(2003年,安徽桐城).中华消化杂志.2004,24(2):126.
[20]中国中西医结合学会.慢性胃炎中西医结合诊治方案(2003年,重庆).中国中西医结合杂志.2005,25(6):172-176.
[21]孙传兴,主编.临床疾病诊断依据治愈好转标准.人民军医出版社.1998年,第2版:72.
[22]罗开云.白花蛇舌草、半枝莲治疗慢性胃炎87例.中国中西医结合脾胃杂志.2000,8(2):116.
[23]沈映君主编.中药药理学.人民卫生出版社.2000年,第1版:955.
[24]周金黄.中药药理学.上海科学技术出版社.1986年,第1版:245.
[25]沈映君主编.中药药理学.人民卫生出版社.2000年,第1版:885.
[26]夏玉亭,吴云林,房殿春,主编.胃病诊治进展.上海科技教育出版社.2005年,第1版:33.
[27]张宝恒.乌拉尔甘草的抗炎作用.中草药.1991,22(10):542.
[28]脱守文.柴胡注射液对小鼠腹腔巨噬细胞表面FG受体的影响.中药药理与临床.1985,1(1).165.
[29]金航,张志军.汉方药对胃粘膜及胃动力的影响.国外医学中医中药分册.1997,19(2):19
[30]Hirano H,Osawa E,Yamaoka,etal.Gastric-mucous membrane protection activity of coptisine derivatives Biolpharm Bull,2001(11):1277.
[31]Shimiz K,etal.New derivatives of saiko saponins.Chem Pharm Bull,1985,33(8):3349.
[32]杨耀芳.白芍总甙对大鼠血小板聚集的影响.安徽中医学院学报.1993,12(1):51.
[33]徐建国,张梅涧.幽门弯曲菌的中药药敏实验.北京中医.1991,(4)52.
[34]马有度 主编.医方新解.上海科学技术出版社.1980年,第1版:46.
[35]王绪霖,缴稳玲,吕宗舜.抑制幽门螺杆菌中药的初步筛选.中国中西医结合脾胃杂志.1994,14(9):534.
[36]徐州,周德端,段国勋.中药对幽门螺杆菌抑杀作用的试验研究.中国医药学报.1993,8(5):281.
[37]张琳,杨连文,郑晓光,等.中药对空腹弯曲菌与门螺旋杆菌的抑制作用.中国中西医结合脾胃杂志.1994,2(1):32-33.
[38]王绪霖,缴稳玲,吕宗舜.抑制幽门螺杆菌中药的初步筛选.中国中西医结合脾胃杂志.1994,14(9):534.
[39]任平.四君子汤对脾虚模型大鼠胃泌素和前列腺素E_2含量的影响.中药药理与临床.1994,10(6):7.
[40]彭成.四君子汤对消化、运动、吸收的实验研究.中药药理与临床.1995,11(5):6.
[41]李贵海.枳壳挥发油含量对小鼠胃肠推进的影响.中药饮片.1993,(1):20.
[42]王浴生.中药药理与应用.人民卫生出版社.1983年,第1版:521.
[43]周金黄.中药药理学.上海科学技术出版社.1986年,第1版:113.
[44]李仪奎,王钦茂.中药药理实验方法学.上海科学技术出版社.1991年,第1版:300.
[45]雒明池.中医药治疗慢性萎缩性胃炎疗效分析.天津中医药.2007,24(8):281-282.
[46]江苏新医学院.中药大辞典(上).上海人民出版社.1977年,第1版:569.
[47]许长照.健脾药(四君子汤和茯苓汤)对Eca10g食管癌和肺鳞癌细胞分裂的影响.中药药理与临床.1985,(创刊号):15.
[48]李广勋.中药药理毒理与临床.天津科技翻译出版公司.1992年,第1版:448.
[49]高学敏,主编.中药学(中医药高级丛书).人民卫生出版社.2000年,第1版.
[50]周凤梧.古今方药纵横.人民卫生出版社.1987年,第1版:257.
[51]黄玲.党参川芎蒲公英及其配伍复方抗胃溃疡与抗胃粘膜损伤作用与机制研究.中药药理与临床.1991,7(5):10.
[52]王辉武.中药新用.科学技术文献出版社重庆分社.1986年,第1版:311.
[53]邓伟民,唐庚云,许鑫梅,等.消胀冲剂治疗慢性萎缩性胃炎的临床研究.中国中医药科技.1997,4(4):201.
[1]韩捷.张自平教授治疗慢性胃炎经验.光明中医.2007,22(5):24-25.
[2]朱梅萍,张正利,林江.蔡淦治疗慢性胃炎的临床经验.上海中医药杂志.2006,40(7):12-13.
[3]邓沂,崔庆荣,李金田,等.于己百诊治慢性胃炎经验.世界中医药.2006,1(1):30-31.
[4]方胜林.吴秋玲治疗慢性胃炎经验.四川中医.2006,24(12):5-6.
[5]裴林,李刚,顾洁.李佃贵教授治疗慢性胃炎经验介绍.新中医.2007,39(3):13-14.
[6]张声生,牧童,汪红兵,等.慢性浅表性胃炎证候分布的研究.中华中医药杂志.2007,22(1):18-21.
[7]卢成孝.辨证治疗慢性浅表性胃炎80例.实用中医内科杂志.2007,21(3):
[8]黄雪萍.辨证治疗慢性浅表性胃炎54例.实用中医内科杂志.2006,20(3):254-255.
[9]卫永琪.辨证治疗慢性浅表性胃炎81例.实用中医药杂志.2005,21(1):12-13.
[10]方东行.治疗慢性浅表性胃炎的体会.时珍国医国药.2001,12(5):443.
[11]于建文.山西中医.辨证治疗浅表性胃炎.2005,21(3):25.
[12]郑建民.半夏泻心汤治疗慢性浅表性胃炎180例.浙江中西医结合杂志.2005,15(10):647-648.
[13]刘建吉.柴胡桂枝汤治疗慢性浅表性胃炎临床研究.中外健康文摘.2007,4(6):659-660.
[14]朱晓,王霞.加味六君子汤治疗慢性浅表性胃炎临床观察.潍坊医学院学报.2006,28(1):45-46.
[15]胡志明,曾玉芬.湖南中医杂志.天台乌药散治疗慢性浅表性胃炎65例.22(5):53-54.
[16]王钢,刘红玉.温胆汤加减方治疗慢性浅表性胃炎58例.现代中西医结合杂志.2004 13(3):315-316.
[17]何剑荣,魏卓红.和胃调肝胶囊治疗慢性浅表性胃炎200例疗效观察.新中医.2007,39(7):29-30.
[18]王树桂,朱敏嘉.胃力康颗粒剂治疗慢性浅表性胃炎100例临床观察.广西医学.2005,27(9):1407-1408.
[19]李颖,辛素文,孙吉华.调胃颗粒治疗慢性浅表性胃炎的临床与实验研究.湖北中医杂志.2002,24(6):27-28.
[20]欧琴,何坚.中西医结合治疗肝气郁结型慢性浅表性胃炎临床观察.广西中医药.2002,25(6):15-16.
[21]马孝义.中西医结合治疗慢性浅表性胃炎56例.天津中医药.2006,23(5):412.
[22]宋建宁,陈庆龄.穴位注射、针刺治疗慢性浅表性胃炎70例疗效比较.福建医学.2002,24(5):16.
[23]辛银虎,陈小玲.温针治疗脾胃虚寒型慢性浅表性胃炎52例.陕西中医.2005,26(9):959-960.
[24]洪钰芳,李虹虹,秦亮甫.针药结合治疗慢性胃炎90例临床观察.上海针灸杂志.2005,24(9):21-22.
[1]杨丽华,杨戈,马春.活血化瘀法在慢性萎缩性胃炎治疗中的作用.吉林中医药.2006,26(3):16.
[2]陈允旺.益气活血法治疗慢性萎缩性胃炎之浅识.陕西中医.2006,27(5):638-640.
[3]王禄.治疗慢性萎缩性胃炎的体会.中医研究.2005,18(10):59.
[4]张竞之,吴伟伟,涂志红.涂福音教授治疗慢性萎缩性胃炎的经验.河南中医.2005,25(11):15-16.
[5]李儒文.慢性萎缩性胃炎辨治的思路和方法.吉林中医药.2006,26(2):12-13.
[6]邱绮玉,章菊花.舌脉诊对中医药治疗慢性萎缩性胃炎的临床指导意义.湖北中医学院学报.2000,2(4):37.
[7]柯莹玲,单兆伟.542例慢性萎缩性胃炎患者中医辨证分型与病因分析.辽宁中医杂志.2006,32(2):161.
[8]顾缨,单兆伟.单兆伟教授治疗慢性萎缩性胃炎经验.南京中医药大学学报.2005,21(3):184.
[9]苑述刚.滋阴益气法治疗慢性萎缩性胃炎103例.中医药学刊.2005,26(10):1766-1767.
[10]柯莹玲,单兆伟.辨证治疗慢性萎缩性胃炎癌前病变患者78例.上海中医药大学学报.2005,19(4):18-20.
[11]陈良金.慢性萎缩性胃炎辨证分型与证候特点探析.时珍国医国药.2005,16(11):1149.
[12]游涛,徐淑静.慢性萎缩性胃炎的中医辨治体会.吉林中医药.2006,26(3):29-30.
[13]杨锦侠,张升良,杨小丽.滋阴益气法治疗慢性萎缩性胃炎103例.现代中医药.2006,26(53):11-12.
[14]陈一斌.益胃汤治疗慢性萎缩性胃炎60例.河南中医.2006,26(3):34.
[15]丁静.清炎益胃汤治疗慢性萎缩性胃炎30例.吉林中医药,2006,26(5):16.
[16]练慧,张正利.柴胡疏肝散合四君子汤治疗慢性萎缩性胃炎47例.上海中医药 杂志.2006,40(5):27-28.
[17]史海霞,胡运莲.加味左金丸治疗慢性萎缩性胃炎临床研究.湖北中医杂志.2007,29(1):34.
[18]蔡锦莲,李爱娣,曾兰英.萎胃散治疗慢性萎缩性胃炎临床研究.河南中医.2006,26(5):28-30.
[19]卓玉珍,袁红梅,王学,等.善胃方对慢性萎缩性胃炎患者P_(16)蛋白的影响.天津中医药.2006,23(1):61-63.
[20]刘启泉,王志坤,白海燕.胃安颗粒治疗慢性萎缩性胃炎合并消化性溃疡临床观察.辽宁中医杂志.2005,32(12):1265-1266.
[21]胡俊铭.健胃汤治疗慢性萎缩性胃炎的临床观察.湖北中医学院学报杂志.2002,4(3):42.
[22]董崇海,曲玲,王有广,等.安中舒胃汤联合亚硒酸钠治疗慢性萎缩性胃炎的临床研究.中医药学报.2006,34(1):44-46.
[23]孙玉霞,李苏民.针灸治疗慢性萎缩性胃炎30例.陕西中医.2005,26(9):955.
[24]谢文霞,曹高忠,朱启槐,等.电针加穴位注射治疗慢性萎缩性胃炎35例.浙江中医杂志.2005,40(9):401.